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evolution of genomic structures on mammalian sex chromosomes.throughout mammalian evolution, recombination between the two sex chromosomes was suppressed in a stepwise manner. it is thought that the suppression of recombination led to an accumulation of deleterious mutations and frequent genomic rearrangements on the y chromosome. in this article, we review three evolutionary aspects related to genomic rearrangements and structures, such as inverted repeats (irs) and palindromes (pds), on the mammalian sex chromosomes. first, we describe the stepwise mann ...023024603
protective cd8+ t-cell immunity to human malaria induced by chimpanzee adenovirus-mva immunisation.induction of antigen-specific cd8(+) t cells offers the prospect of immunization against many infectious diseases, but no subunit vaccine has induced cd8(+) t cells that correlate with efficacy in humans. here we demonstrate that a replication-deficient chimpanzee adenovirus vector followed by a modified vaccinia virus ankara booster induces exceptionally high frequency t-cell responses (median >2400 sfc/10(6) peripheral blood mononuclear cells) to the liver-stage plasmodium falciparum malaria a ...024284865
memory and foraging theory: chimpanzee utilization of optimality heuristics in the rank-order recovery of hidden foods.many models from foraging theory and movement ecology assume that resources are encountered randomly. if food locations, types and values are retained in memory, however, search time could be significantly reduced, with concurrent effects on biological fitness. despite this, little is known about what specific characteristics of foods, particularly those relevant to profitability, nonhuman animals can remember. building upon previous observations, we hypothesized that chimpanzees (pan troglodyte ...023226837
an evolutionary relationship between stearoyl-coa desaturase (scd) protein sequences involved in fatty acid metabolism.stearoyl-coa desaturase (scd) is a key enzyme that converts saturated fatty acids (sfas) to monounsaturated fatty acids (mufas) in fat biosynthesis. despite being crucial for interpreting scds' roles across species, the evolutionary relationship of scd proteins across species has yet to be elucidated. this study aims to present this evolutionary relationship based on amino acid sequences.026989730
comparative and evolutionary insights into cd4 gene across mammalian and avian taxa.the present day genetic architecture of a species bears much significance to its closely related species which is due to species-specific differences, shaped by different evolutionary forces across time scale. with the availability of whole genome sequence of several closely related species, it is now possible to infer evolutionary patterns of genes and genomes in specific lineages. to this respect, cd4 gene, primarily responsible for defensive mechanism in human, is conserved across a few taxa, ...026767121
comparative in silico study of sex-determining region y (sry) protein sequences involved in sex-determining.the sry gene (sry) provides instructions for making a transcription factor called the sex-determining region y protein. the sex-determining region y protein causes a fetus to develop as a male. in this study, sry of 15 spices included of human, chimpanzee, dog, pig, rat, cattle, buffalo, goat, sheep, horse, zebra, frog, urial, dolphin and killer whale were used for determine of bioinformatic differences.027536700
on the minute structure of the brain, in the chimpanzee and in the human idiot: compared with that of the perfect brain of man; with some reflections on the cerebral functions. 184221373564
on some points in the anatomy of the chimpanzee. 186717230717
the muscles and nerves of a chimpanzee (troglodytes niger) and a cynocephalus anubis. 187117230919
on some points in the anatomy of the chimpanzee (anthropopithecus troglodytes). 188317231511
the mental powers of the chimpanzee. 188917754069
report lxxxiii: some experiments on enterica, scarlet fever, and measles in the chimpanzee : [a preliminary communication.]. 190420761451
cranium of a chimpanzee, showing metopic suture; also fontanelle and sutural bone-plates. 191117232908
observations on experimental typhoid infection of the gall bladder in the rabbit.1. besredka's living sensitized vaccine, given intravenously, does not produce a typhoid lesion of the gall bladder in the rabbit. 2. the first transplant of this vaccine is capable of producing this lesion. hence this vaccine is not entirely safe to handle. 3. regular infections of the gall bladder have not been produced by carrying a known pathogenic strain on rabbit blood agar, by successive passage through animals, or by the use of freshly isolated strains. 4. no evidence could be demonstrat ...191419867843
serological studies on the blood of the primates : i. the differentiation of human and anthropoid bloods.while the precipitin tests do not differentiate, according to the results of previous workers, between the serum proteins of man and chimpanzee, a clear-cut differentiation between the blood cells of man and the anthropoids was obtained by means of hemagglutinins. according to our tests on bloods of whites and negroes, constant racial serological differences among human bloods, if they exist at all, are certainly smaller than the differences between the bloods of man and the anthropoid apes. the ...192519869094
serological studies on the blood of the primates : ii. the blood groups in anthropoid apes.the bloods of twenty-one anthropoid apes have been examined serologically. it was found possible to assign each to one of the four human blood groups. the isoagglutinogens of the anthropoids were found to be identical with those of human blood. these very same factors could not be demonstrated in the blood of the lower monkeys. in the blood of the fourteen chimpanzees examined only the isoagglutinogen a has been found, whereas both a and b were present in the blood of the six orangs. the signifi ...192519869095
etiology of oroya fever : iv. the effect of inoculation of anthropoid apes with bartonella bacilliformis.the inoculation of a chimpanzee with cultures and a passage strain of bartonella bacilliformis induced local reactions which, while definite and characteristic, progressed less rapidly and were much less striking than those in the control rhesus monkey. bartonella bacilliformis was demonstrated in the blood corpuscles with difficulty, and the fever was slight compared with the high and persistent fever of the rhesus monkey. in both the swelling of the lymph glands was an early symptom and consta ...192619869218
etiology of oroya fever : vii. the response of the skin of macacus rhesus and anthropoid apes to inoculation with bartonella bacilliformis.bartonella bacilliformis failed to induce lesions when merely rubbed on the surface of the intact skin of a chimpanzee, an ourang-utan, and numerous macacus rhesus monkeys, although when applied to the scarified skin of the same animals it gave rise to extensive lesions. application of infectious material to the scarified skin did not always induce verruga lesions, but intradermal inoculation almost invariably gave rise to nodule formation. the localization of bartonella bacilliformis in the ski ...192719869265
etiology of oroya fever : viii. experiments on cross-immunity between oroya fever and verruga peruana.nine monkeys (macacus rhesus) and a chimpanzee which had recently recovered from an infection with the oroya strain of bartonella bacilliformis were tested for immunity against the verruga strain of bartonella bacilliformis as well as against the homologous strain. complete immunity to both strains was demonstrated. the result establishes the identity of the strains and is in agreement with the result of comparative serological study. the criteria of recovery include not only the subsidence of f ...192719869288
studies in the common cold : iv. experimental transmission of the common cold to anthropoid apes and human beings by means of a filtrable agent.1. chimpanzees are highly suitable animals for the experimental study of human upper respiratory infections. 2. human colds have been successfully transmitted to apes and human volunteers in 44 per cent of instances tried by means of filtered nasal washings obtained from colds. 3. certain types of infectious colds are caused by a filtrable agent.193019869798
the arterial supply of the cerebral cortex in the chimpanzee (anthropopithecus troglodytes). 193017104307
australopithecus not a chimpanzee. 193017843430
the cultivation of a species of troglodytella, a large ciliate, from the chimpanzee. 193217779662
studies on the etiology of spontaneous conjunctival folliculosis of monkeys : ii. bacteriological experiments.in the bacteriological study here reported, we undertook an investigation of the flora associated with spontaneous conjunctival folliculosis. following the plan of noguchi (2), monkeys and chimpanzees were inoculated with the different organisms recovered from affected tissues. by this means, we disclosed among the bacteria a new species, bacterium simiae, which was found to be specifically active, in that it induced follicular reactions in the conjunctiva apparently indistinguishable from the d ...193319870166
an investigation into the significance of hormonal factors in experimental poliomyelitis.1. adult rhesus monkeys possess frequently a greater resistance to experimental infection with poliomyelitis virus than young monkeys as indicated by the prolongation of the incubation period and the content of feeble neutralizing substances in the normal serum. 2. virucidal substances can be demonstrated in the normal serum of subadult chimpanzees. 3. immature monkeys prepared with glandular anterior pituitary hormones and anterior pituitary-like principles from the urine of pregnant women are ...193419870230
studies on the etiology of spontaneous conjunctival folliculosis of rabbits : ii. bacteriological investigations.before summarizing the experimental results presented herewith, a brief review is indicated of our study on follicular conjunctivitides existing in the different species of animals thus far examined. spontaneous follicular conjunctivitis of monkeys and chimpanzees, which resembles the early, or follicular, stages of human trachoma, has been shown to be an infectious disease, and to arise from the action of a bacterium and not an ultramicroscopic virus (2, 10). a new species of organism, designat ...193419870308
malaria from a zoological point of view: (section of comparative medicine).protozoal parasites occurring in the red cells of mammals are: hepatozoon, babesia, theileria and plasmodium. the frequency with which these forms occur differs considerably in the different mammalian orders. but whilst there is a relationship apparent between the mammalian stem and the form of parasite, there appears to be an even closer association with the type of blood-sucking arthropods which the mode of life of the animals in a particular stem favours. ungulates in the days of their greate ...193419989868
the menstrual cycle of the primates: part vii. the sexual skin of the chimpanzee. 193417104514
a second-generation captive-born chimpanzee. 193517748586
the birth of chimpanzee at the zoological gardens, london: (section of obstetrics and gynæcology). 193520914700
the birth of chimpanzee at the zoological gardens, london: (section of obstetrics and gynaecology). 193519990303
the external configuration of the cerebral hemispheres of the chimpanzee. 193617104620
chimpanzee metabolism. 193616588092
the sexual and reproductive cycles of chimpanzee. 193616577711
death of the oldest chimpanzee in captivity. 193617742371
concerning reproduction in the chimpanzee. 193721433749
the thalamus of the chimpanzee: iv. thalamic projections to the cerebral cortex. 193817104750
the time of ovulation in chimpanzees. 193821433772
the use of the friedman test for pregnancy with chimpanzees. 193921433870
pre-linguistic sign behavior in chimpanzee. 193917819460
laboratory chimpanzees. 194017796112
the chromosomes of the chimpanzee. 194017783328
chimpanzee handedness. 194117801500
studies of infant chimpanzees. 194217818874
the ultracentrifuge as an aid in the detection of poliomyelitis virus.1. by means of differential ultracentrifugation, a purified and concentrated macromolecular fraction has been regularly obtained from infected human, monkey, and chimpanzee stools. this fraction was isolated from sixteen stools in which virus was thought to be present, and inoculated intracerebrally into sixteen monkeys, of which fifteen developed poliomyelitis. 2. eleven stool specimens in which virus was suspected, when tested separately in eleven monkeys by the intra-abdominal-intranasal meth ...194319871276
poliomyelitis by accidental contagion in the chimpanzee.poliomyelitis virus was isolated from the stools of two uninoculated chimpanzees which had been quartered for 6 months in cages adjoining those of rhesus monkeys receiving intranasal inoculations of potent human stools. upon arrival, and for 4 months thereafter, neither chimpanzee had antibody against the virus eventually isolated from it. however, antibody had developed against the animals' own virus strains at the time these were isolated from the feces.194419871425
passive immunity to poliomyelitis in the chimpanzee.a series of 6 chimpanzees was inoculated orally with stool from a poliomyelitis patient. three of these animals had been given 170 cc. of homologous, hyperimmune monkey serum prior to inoculation, while three were unprotected. all 6 of the animals were subsequently shown to have poliomyelitis virus in their stools and characteristic lesions in their central nervous systems although none of them developed paralytic poliomyelitis. all of the immunized animals had demonstrable blood antibody at the ...194519871455
non-paralytic poliomyelitis in the chimpanzee.1. thirteen cases of non-paralytic poliomyelitis infection in chimpanzees are described. nine of these animals were excreting virus in. their stools at periods of from 3 days to 8 weeks following inoculation. 2. all animals killed during the acute stage showed lesions in the brain distributed in centers usually involved in, and compatible with the presence of, poliomyelitic infection. in 2 chimpanzees typical cord lesions were also present. no lesions were found in the brains of 4 control chimpa ...194519871456
poliomyelitis virus in fly-contaminated food collected at an epidemic.poliomyelitis virus has been detected in food exposed to flies at homes of poliomyelitis patients within an epidemic area. this was achieved by feeding such exposed food to chimpanzees which developed subclinical infections or asymptomatic carrier states ascertained by positive stool tests in rhesus monkeys.194517735530
prepubertal castration in the male chimpanzee, with some effects of replacement therapy. 194521011758
hormonal modifications of social behavior; the effect of sex-hormone administration on the social status of a male castrate chimpanzee. 194521004998
failure to transmit infectious hepatitis to chimpanzees. 194521004044
the rh and hr factors in chimpanzees. 194517844227
the recovery of poliomyelitis virus from the stools of experimentally infected monkeys and chimpanzees. 194620992664
the recovery of poliomyelitis virus from the stools of monkeys and chimpanzees experimentally infected by various routes. 194621064605
the relation of the foot of the pre- and postcentral gyrus to taste in the monkey and chimpanzee. 194621066412
the rh system in the chimpanzee. 194617772329
the rh system in the chimpanzee. 194620997616
the rh system in the chimpanzee. 194617814239
estrogens and the sex skin in the male chimpanzee. 194620996891
can chimpanzees become morphine addicts? 194621023310
estrogen-progesterone interaction in the sex-cycle of the chimpanzee. 194621066215
the effect of sex hormones on the dominance-subordination relationships of the castrate female chimpanzee. 194621065905
the mechanism of estrogen induced changes in dominance-subordination relationships in the female chimpanzee. 194621065885
histological appearance of coiled arterioles in the endometrium of rhesus monkey, baboon, chimpanzee and gibbon. 194720266322
the development of visual perception in man and chimpanzee. 194717741054
the significance of lesions in peripheral ganglia in chimpanzee and in human poliomyelitis.1. the peripheral ganglia of eighteen inoculated chimpanzees and thirteen uninoculated controls, and of eighteen fatal human poliomyelitis cases, were studied for histopathological evidence of the route of transmission of virus from the alimentary tract to the cns. 2. lesions thought to be characteristic of poliomyelitis in inoculated chimpanzees could not be sharply differentiated from lesions of unknown origin in uninoculated control animals. moreover, although the inoculated animals as a grou ...194719871611
threshold bleeding and the sex skin in the castrate female chimpanzee. 194718895666
observations on sense of smell in chimpanzees. 194720262469
threshold bleeding and the sex skin in the castrate female chimpanzee. 194720342528
active immunity to poliomyelitis in chimpanzees following subclinical infection.this report is concerned with the production of subclinical poliomyelitis in the chimpanzee, and immunity to such infection. subclinical infection was produced in eight chimpanzees by the administration of virus orally or intracutaneously, and was measured by the production of a virus carrier state and the development of neutralizing antibodies. immunity was tested by attempting to induce the carrier state again by a challenge dose of virus by the same routes. with an homologous strain as the ch ...194719871615
spontaneous neurosis in chimpanzees; theoretical relations with clinical and experimental phenomena. 194720284392
concerning cytoarchitecture of the frontal lobe of chimpanzee, pan satyrus and man, homo sapiens. 194818122903
experimental attempts to transmit phlebotomus (sandfly, pappataci) and dengue fevers to chimpanzees. 194818863715
enteric infections in chimpanzees and spider monkeys with special reference to a sulfadiazine resistant shigella. 194818888330
susceptibility of the chimpanzee to p. malariae of human origin. 194818889635
simple discrimination behavior of young chimpanzees; comparisons with human aments and domestic animals. 194818891159
histologic appearance of coiled arterioles in the endometrium of rhesus monkey, baboon, chimpanzee, and gibbon. 194818932373
observations on the sex skin and sex cycle in the chimpanzee. 194818890098
sex-hormones and social behavior in chimpanzees. 194818882478
the lack of effect of estrogen on the sex skin of the infant male chimpanzee. 194818932470
experimental fort bragg fever (pretibial fever) in chimpanzees. 194818910602
the anatomical basis of phonation in the chimpanzee. 194818902231
analysis of matching behavior in chimpanzee. 194818904766
frontal lobe ablation in chimpanzee; a resume of becky and lucy. 194818106849
retardation in onset of ossification in chimpanzee related to various environmental and physiological factors. 194915409815
conditional matching behavior in chimpanzee; implications for the comparative study of intelligence. 194918143113
the cerebral cortex of the chimpanzee at the time of birth. 194918147138
temperament in chimpanzees; method of analysis. 194918151779
onset of ossification in the epiphyses and short bones of the extremities in chimpanzee. 194918150961
the failure of estrogen to induce changes in the sex skin of the male chimpanzee. 194918109887
experimental infection of the upper respiratory tract of young chimpanzees with group a hemolytic streptococci. 195015415631
some quantitative dental characteristics of the chimpanzee, gorilla and orangutang. 195024538528
fatal ingestion of tintacks by chimpanzee. 195015431494
atypical pneumonia in a chimpanzee treated with chloromycetin. 195015431480
hormonal modification of social behavior; the mechanism of estrogen-induced dominance in chimpanzees. 195015428551
poliomyelitis in chimpanzees; studies in homologous and heterologous immunity following inapparent infection.the response of eighteen chimpanzees to poliomyelitis virus administered orally and cutaneously has been studied. there were no signs of weakness or paralysis in any of the animals. sixteen of the eighteen (89 per cent) became infected as measured by intestinal carriage of virus. only one of twelve was reinfected when challenged with an homologous (or homotypic) strain by the same routes, but seven of ten were reinfected on heterologous challenge. a correlation between the development of humoral ...195015422085
subclinical poliomyelitis in the chimpanzee and its relation to alimentary reinfection. 195015401866
a specific complement-fixation test for infection with poliomyelitis virus.a complement-fixing antigen has been developed, using as source of material cns tissue from newborn mice infected with the newborn mouse-adapted strain of the lansing type, mef1 virus. with this antigen, specific reactions have been obtained with sera from mice, cotton rats, and monkeys immunized with the lansing-type virus, and from monkeys and chimpanzees convalescent from infection with this virus. twenty-one of 35 human sera obtained from individuals convalescent from poliomyelitis were posi ...195114861374
effects of restricted opportunity for tactual, kinesthetic, and manipulative experience on the behavior of a chimpanzee. 195114885499
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