Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| studies on opisthorchis viverrini in thailand. | 1955 | 13258561 | |
| studies on the treatment of opisthorchis viverrini in human infections with quinacrine hydrochloride and chloroquine phosphate. | 1955 | 13268815 | |
| the morphology of the metacercaria of opisthorchis viverrini, with special reference to the excretory system. | 1961 | 13924247 | |
| opisthorchis viverrini in thailand--the life cycle and comparison with o. felineus. | 1965 | 14275209 | |
| clinical manifestations of opisthorchis viverrini infections in thailand. | 1966 | 5959105 | |
| opisthorchis viverrini (poirier, 1886) a trematode parasite of man in west malaysia. | 1969 | 5816416 | |
| the ultrastructure of helminth. vi. the body wall of opisthorchis viverrini (poirier, 1886). | 1971 | 4333630 | |
| socio-economic, health and nutritional status of the villagers in the nong wai irrigation area, khon kaen, northeast thailand. | studies were carried out from june 1974 to may 1975 on the socio-economic status, health and nutritional status of the people in 4 villages, in the irrigation area of the nong wai pioneer agricultural project of khon kaen province, northeast thailand. the result obtained were compared with those in 2 non-irrigated villages in the same province, in order to identify the health and nutritional problems which might arise during the water resource development in the irrigation area. it was found tha ... | 1976 | 1030856 |
| effects of the injectable contraceptive depot medroxyprogesterone acetate in thai women with liver fluke infestation: results after six months. | the effect of the three-monthly injectable contraceptive depot medroxyprogesterone acetate (dmpa) on liver and lipid function was assessed in thai women with liver fluke (opisthorchis viverrini) infestation, dmpa administration being started in the immediate postpartum period. immediate postpartum iud and sterilization acceptors with fluke infestation were recruited as a comparison (control) group for the fluke-positiv dmpa acceptors. comparable groups of fluke-negative acceptors were recruited ... | 1977 | 302157 |
| liver changes in hamsters infected with a liver fluke of man, opisthorchis viverrini. | thirty male syrian golden hamsters were each infected with 100 metacercariae of opisthorchis viverrini. the hamsters were killed at 3, 7, 15, 30, 154 days of infection. the early pathological changes consisted of an acute inflammatory reaction involving the bile ducts of the second order and the portal connective tissue, especially the large veins, as well as focal coagulation necrosis of the liver lobules. as the flukes developed into adults they induced hyperplasia and adenomatous formations o ... | 1978 | 686245 |
| effects of dimethylnitrosamine on induction of cholangiocarcinoma in opisthorchis viverrini-infected syrian golden hamsters. | 1978 | 214229 | |
| opisthorchis viverrini: liver changes in golden hamsters maintained on high and low protein diets. | two groups of hamsters maintained on eight high (25.6%) or low (5.3%) content protein diets were infected with 50 opisthorchis viverrini metacercariae by intragastric inoculation. three animals from each group were sacrificed at 14-day intervals over a 32-week period. two groups of non-infected control animals maintained on identical diets were killed at similar intervals. histological examination revealed qualitatively similar pathological responses to the parasite in both diet groups, but over ... | 1980 | 6110324 |
| helminths in the induction of cancer: opisthorchis viverrini, clonorchis sinensis and cholangiocarcinoma. | opisthorchis and clonorchis parasitize the bile ducts of millions of persons in the far east. the most important aspect of infection with these flukes is their ability to initiate cancer. numerous studies have shown these flukes to occur in association with cholangiocarcinoma far more frequently than can be explained by chance. experimental studies in animals have confirmed the carcinogenic potential of these parasites. although the pathogenesis remains unclear, the initial carcinogenic event is ... | 1980 | 6252671 |
| [clinical trial of niclofolan (bay 9015) in the treatment of human opisthorchiasis. apropos of 51 cases]. | 51 refugees from south east asia infected with opisthorchis viverrini or clonorchis sinensis were included in a therapeutic study with niclofolan (bay 9015) at a dose of 1 mg/kg body weight given three times at intervals of 48 hours. clinical and biological tolerance was carefully controlled and in all cases proved to be very good or excellent particularly in several patients with various haemoglobinopathies or erythrocytal enzymopathies (g-6-pd deficiency). of the total of 51 cases, 17 were cur ... | 1980 | 7014011 |
| opisthorchis viverrini: partial success in adoptively transferring immunity with spleen cells and serum in the hamster. | three groups of golden syrian hamsters received intraperitoneally either, (1) 1 x 10(7) spleen cells, (2) 0.5 ml. serum or, (3) 1 x 10(7) spleen cells plus 0.5 ml. serum, from donors infected 6 weeks previously with 25 opisthorchis viverrini metacercariae, one day before and at the same time as challenge with 25 metacercariae. three groups of control animals received the same quantities of spleen cells, serum or an admixture of both from normal non-infected donors in the same manner followed by ... | 1980 | 7217648 |
| potential health hazards of the water resources development: a health survey in the phitsanulok irrigation project, nan river basin, northern thailand. | a health survey was carried out among residents of 33 villages under the phitsanulok irrigation project area, nan river basin, northern thailand, whereby general health conditions were examined including intradermal tests for schistosomiasis japonica, stools for intestinal parasites and sera tested by circumoval precipitin test for antibodies to s. japonicum and by agglutination test for leptospiral infection. health investigations revealed that 913 (60.9%) of 1,499 people examined had experienc ... | 1980 | 7221699 |
| [intestinal helminths in bangkok stray dogs and their role in public health (author's tranls)]. | feces examination of 107 stray dogs in bangkok, thailand, on intestinal helminths showed the following rates: hookworms 100%, trichuris vulpis 54.2%, toxocara canis 6.5%, gnathostoma spinigerum 2.8%, spirocerca lupi 17.8%, diphyllobothrium mansoni 1.9%, and opisthorchis viverrini 1.9%. out of these species hockworms (especially a. braziliense), t. canis, g. spinigerum, and d. mansoni are important sources of human cutaneous or visceral larva migrans, the latter two being special parasites of the ... | 1980 | 7435002 |
| field studies on the bionomics of bithynia siamensis siamensis and the transmission of opisthorchis viverrini in bangna, bangkok, thailand. | a field study on the bionomics of bithynia siamensis siamensis and the transmission patterns of opisthorchis viverrini was carried out in bangna, bangkok, thailand, from may 1975 to april 1976. snail populations were found to fluctuate according to rainfall. during the high rainfall period where snail habitats were deep, snail populations recovered at the water surface were higher than those recovered on the mud bottom; during the low rainfall perod where snail habitats were shallow, snails were ... | 1980 | 7444576 |
| [praziquantel in the treatment of far eastern hepatic distomiasis caused by clonorchis sinensis or opisthorchis viverrini]. | forty-six patients infected with opistorchis viverrini and/or clonorchis sinensis, 24 males and 22 females, all laotian or vietnamese, aged 7 to 68, weighing 18 to 70 kg, were detected by parasitological stool examinations, numeration of eggs per gram of feces (e.p.g.). in this manner we observed 23 light infestations (1-999 e.p.g.), 20 moderate infestations (10,000-29,999 e.p.g.). before treatment, all these patients were submitted to a complete history and clinical examination with biological ... | 1981 | 7296740 |
| the in vitro effects of serum on the adults, metacercariae, and eggs of opisthorchis viverrini. | adult and juvenile opisthorchis viverrini liver-flukes incubated in hamster chronic infection serum (cis) developed tegumental precipitates which enclosed the entire parasite. adult worms appeared dead by 48 hours in cis and juvenile worms by 18 hours. no such reactions were observed in normal hamster serum (nhs). heat inactivation of cis at 56 degrees c abolished the precipitin reactivity against both adult and juvenile parasites though reactivity was regained upon addition of nhs or guinea-pig ... | 1981 | 7330943 |
| treatment of opisthorchis viverrini with mebendazole. | thirty-six hospitalized thais (21 males, 15 females, 9 to 63 years of age) with opisthorchis viverrini infection were treated with mebendazole in dosages of 20 mg/kg body weight for 4 weeks and 30 mg/kg body weight for 3 or 4 weeks. the drug was found to be effective when given in dosages of 30 mg/kg body weight for 3 to 4 weeks only a few eggs being found in the stool of one of 27 persons at 3 or 4 weeks post-treatment. in follow-up examination at 6 months, only two of 15 persons available were ... | 1981 | 7344109 |
| field trial of praziquantel in human opisthorchiasis in thailand. | praziquantel is an excellent drug for treatment against opisthorchis viverrini infection. sixty cases of opisthorchis viverrini infection were treated with praziquantel, 3 x 25 mg/kg body weight for one day, except one case that was retreated with the same regimen at one month after the first treatment, and the cure rate was 100.0% at one year after the treatment. the side effects of the drug were headache, lassitude, sleepiness, and diarrhoea, but most of these were only in mild degree. other l ... | 1981 | 7344110 |
| praziquantel in clonorchiasis and opisthorchiasis. | a single stool examination revealed pathogenic intestinal parasites in 462 (58%) of 796 vietnamese and cambodian refugees. 56 (7.0%) were infected with clonorchis sinensis and/or opisthorchis viverrini. these patients received praziquantel in a dosage of 20 mg/kg bwt. p.day on 3 consecutive days. parasitological controls were completed after 12 months. no further excretion of eggs could be detected in 88% of the patients. concurrent infections with other trematodes and cestodes were also cured. ... | 1981 | 7345688 |
| studies on the chemotherapy of human opisthorchiasis: ii. clinical trial of niclofolan. | a clinical trial of niclofolan on human opisthorchiasis was carried out in 60 patients admitted to the hospital for tropical diseases. two dosage regimen, 2 mg and 3 mg per kg body weight repeated after a 72 hour interval was administered to 31 and 4 patients respectively. comparative evaluation with the placebo group of 25 patients was made by the stoll count on day 20, 40 and 60 after treatment. on day 60 percentage egg reduction of the treated and the placebo groups were similar. mild and tra ... | 1981 | 7020093 |
| liver-fluke infection as an aetiological factor in bile-duct carcinoma of man. | this paper reviews, with particular reference to opisthorchis viverrini, the evidence that opisthorchiasis and clonorchiasis are aetiological factors in the causation of human bile-duct cancer, especially cholangiocarcinoma, and considers the other aetiological factors which may be operating. the epidemiology, pathology in man and experimental animals, and histogenesis of cholangiocarcinoma associated wtih liver-fluke infection are also considered. | 1981 | 6277052 |
| potentiation by the human liver fluke, opisthorchis viverrini, of the carcinogenic action of n-nitrosodimethylamine upon the biliary epithelium of the hamster. | 1982 | 6295426 | |
| alpha 1-antitrypsin, alpha 1-antichymotrypsin and alpha 2-macroglobulin in human liver fluke (opisthorchiasis). | in mild and moderate opisthorchis viverrini infection it is difficult to find clinical signs for diagnosis. also routine clinical chemical reactions often fail to demonstrate changes in these patients. this study showed a significant increase of serum proteinase inhibitors, alpha 2-macroglobulin, alpha 1-antitrypsin and alpha 1-antichymotrypsin in patients suffering from o. viverrini infection compared with healthy controls. the increase of proteinase inhibitors together with other biochemical l ... | 1982 | 6182657 |
| serodiagnosis of opisthorchis viverrini infestation by an enzyme immuno-assay. | the application of an enzyme immuno-assay is evaluated with regard to antibody reactivity to opisthorchis viverrini antigen in 20 laotian patients and control groups including patients with other helminthic infections as well as persons without parasitic infestation. it is concluded that the enzyme immuno-assay indicates infection by o. viverrini. in certain circumstances, which are discussed, the test may serve for valuation of treatment. | 1982 | 7048673 |
| anti-p1, allohemagglutinins associated with clonorchis sinensis and opisthorchis viverrini infections in patients from southeast asia. | an automated assay of anti-p1 allohemagglutinins has been carried out on sera of 61 individuals from southeast asia : 28 with clonorchiasis, 18 with opisthorchiasis and 15 control subjects. anti-p1 activity was detected in 61% of the opisthorchiasis sera, 57% of the clonorchiasis sera and in 26.6% of the control subjects. their concentration, in the sera, was low in control subjects and exceptionally high in clonorchiasis and opisthorchiasis (up to 13 and 22 times the maximum concentration of th ... | 1982 | 7051340 |
| opisthorchis viverrini : intensity and rates of infection in cyprinoid fish from an endemic focus in northeast thailand. | the infection rates and monthly variations in intensities of opisthorchis viverrini infection in cyprinoid fish from an endemic focus in northeast thailand were investigated between april 1980 and march 1981. out of six species of cyprinoid fish examined, four were found to harbour o. viverrini metacercariae. all four species of infected fish showed high rates of infection. among the four species of o. viverrini infected fish, cycloccheilicthys apagon and puntius leiacanthus were found in abunda ... | 1982 | 7112213 |
| acquired resistance to opisthorchis viverrini in the hamster. | two groups of ten hamsters received a primary challenge of five opisthorchis viverrini metacercariae intragastrically (groups i and iii) and a third group was left untreated (group ii). 90 days after the primary challenge groups i and ii were given a further 50 metacercariae. animals were killed 35 days after the secondary challenge and worm burdens and faecal egg counts evaluated. compared with group ii animals, group i showed a 24.88% reduction in mean liver worm burden, a difference which was ... | 1982 | 7164147 |
| effects of physico-chemical factors on the infection of hamsters by metacercariae of opisthorchis viverrini. | 1982 | 7170645 | |
| effect of culture media on production of excretory-secretory products and egg output of opisthorchis viverrini in vitro. | adult opisthorchis viverrini were maintained metabolically active in vitro for an extended period in earle's basal medium (bme). the worms were most active during the first 7 to 10 days of incubation and the culturing fluids were found to react in immunodiffusion with antisera. the mean survival period and egg output per worm per day could be enhanced when bme was supplemented with 5% normal, human bile but not with the same concentration of bile ultrafiltrate. a similar degree of enhancement wa ... | 1982 | 6897077 |
| morbidity in relation to intensity of infection in opisthorchiasis viverrini: study of a community in khon kaen, thailand. | a study of the prevalence and intensity of opisthorchiasis viverrini in relation to morbidity as determined by standard medical examination was carried out in nong ranya, a small village containing 309 people in northeastern thailand. opisthorchis viverrini infection as determined by stoll's quantitative egg count method had an overall prevalence of 94% and reached 100% prevalence in most age groups above the age of 10 years. with respect to intensity, 6% were uninfected, 26% had light (less tha ... | 1982 | 6983303 |
| attempts to induce protective immunity in hamsters against infection by a liver fluke of man (opisthorchis viverrini). | the development of acquired resistance in opisthorchiasis was studied in hamsters experimentally infected with opisthorchis viverrini. the induction of protective immunity was attempted by first exposing adult female golden syrian hamsters to 1, 2 or 3 doses of infective metacercariae obtained from naturally infected cyprinoid fishes and then reinfecting them with 80 metacercariae. in other experiments, animals that were infected with 50 metacercariae were treated with praziquantel prior to bein ... | 1983 | 6835694 |
| liver collagen turnover in hamsters during infection by the human liver fluke, opisthorchis viverrini. | hamsters infected with opisthorchis viverrini, a liver fluke of man, showed an increased deposition of collagen in their livers. however, increased collagen breakdown as well as its synthesis were observed in the infected livers. thus, stimulated synthesis might be the main factor responsible for the net increase in collagen content. synthesis and degradation increased to a greater extent in short-term infection than in long-term infection whereas the hepatic collagen content was equally elevate ... | 1983 | 6877280 |
| a comparison of a modified quick-kato technique and the stoll dilution method for field examination for opisthorchis viverrini eggs. | a modified quick-kato technique and the stoll dilution method for the diagnosis of opisthorchis viverrini infection were compared from the standpoints of both replicability and sensitivity. one stoll dilution preparation and two modified quick-kato smears were prepared from single stool specimens collected from 221 persons in a village in north-eastern thailand. stool examinations were made in duplicate for each technique by two examiners, and the averages of the raw egg counts were used to esti ... | 1983 | 6630991 |
| humoral immune responses in hamsters infected with opisthorchis viverrini. | the kinetics and nature of humoral immune responses to somatic and excretory-secretory (es) antigens were investigated in hamsters experimentally infected with different numbers of opisthorchis viverrini. es antigens were obtained from the in vitro culture of adult flukes and somatic antigens were aqueous extracts of adult flukes. antibodies in the serum and bile of infected animals were determined by the microhaemagglutination technique, using glutaraldehyde fixed sheep red blood cells sensitiz ... | 1983 | 6635763 |
| opisthorchis viverrini: the relationship between egg production, worm size and intensity of infection in the hamster. | worm recoveries, egg production and worm lengths were determined in golden syrian hamsters given between five and 200 opisthorchis viverrini metacercariae. animals given five, 10 or 20 metacercariae showed similar worm recovery rates of 38%, 36% and 37%, respectively, whereas animals given 50, 100 or 200 metacercariae gave recoveries of 49%, 65% and 54%, respectively. the distribution of worms between right, left and middle liver lobes was similar for animals with between one and 43 worms but di ... | 1983 | 6636282 |
| liver collagen in opisthorchis viverrini infected hamsters following praziquantel treatment. | the dose of praziquantel required to achieve a 100% worm reduction in o. viverrini infected hamsters was found to be 300 mg/kg body weight. the drug was administered orally for 1 day by dividing a total dose into 3 equal doses at 4 h interval. the effect of praziquantel treatment on liver collagen was followed by measuring liver collagen content in at various intervals after administration of the drug. a decrease in collagen content in the infected livers occurred within a few weeks following th ... | 1983 | 6658499 |
| ultrastructural investigations on the effects of praziquantel on human trematodes from asia: clonorchis sinensis, metagonimus yokogawai, opisthorchis viverrini, paragonimus westermani and schistosoma japonicum. | the effect of praziquantel (biltricide) on the ultrastructure of trematodes pathogenic to man in asia was investigated in: clonorchis sinensis, opisthorchis viverrini, schistosoma japonicum, metagonimus yokogawai, and paragonimus westermani. the different parasites were isolated from their respective experimental hosts and uniformly incubated for 5, 15, 30 or 60 min at 37 degrees c in medium tc 199 containing 0, 1, 10 or 100 micrograms praziquantel/ml. all parasites exposed to praziquantel were ... | 1983 | 6338885 |
| stimulation of ca2+ uptake in the human liver fluke opisthorchis viverrini by praziquantel. | 45ca2+ uptake by the human liver fluke opisthorchis viverrini is enhanced by praziquantel. the drug-induced 45ca2+ uptake was dependent on the presence of ca2+ and was attenuated in the presence of 10 mm mg2+. la3+ and vanadate at concentration of 1 mm partially reduced the amount of 45ca2+ uptake into the liver fluke in response to praziquantel treatment. the stimulating effect of praziquantel was eliminated in the presence of 10 microm verapamil. these findings suggest that praziquantel increa ... | 1983 | 6304438 |
| promotion of n-nitrosodimethylamine-initiated bile duct carcinogenesis in the hamster by the human liver fluke, opisthorchis viverrini. | four groups of male golden syrian hamsters were treated as follows: group i received 50 opisthorchis viverrini metacercariae followed 41 days later by a single oral dose of 1.6 mg n-nitrosodimethylamine (ndma). group ii received a single oral dose of 1.6 mg ndma followed 96 h later by 50 o. viverrini metacercariae, group iii received a single oral dose of 1.6 mg ndma only and group iv 50 o. viverrini metacercariae only. mortality was highest in group i and ii animals receiving both ndma and para ... | 1983 | 6307539 |
| increased liver prolyl hydroxylase activity in hamsters infected with the human liver fluke opisthorchis viverrini. | a parallel increase in liver collagen content and prolyl hydroxylase activity was observed in hamsters infected with the human liver fluke opisthorchis viverrini. they were elevated at 2 weeks after infection, gradually increased to approximately 2-fold at 7-11 weeks of infection, and then declined as with duration of infection time increasing from 11 to 22 weeks. | 1983 | 6309553 |
| liver procollagen prolyl hydroxylase in opisthorchis viverrini infected hamsters after praziquantel administration. | infection of hamsters by the human liver fluke opisthorchis viverrini elevated liver procollagen prolyl hydroxylase activity, reflecting increased collagen biosynthesis. the increase was proportional to the intensity of infection. however, the infected liver procollagen prolyl hydroxylase activity decreased after administration of praziquantel 300 mg kg-1 body weight, and approached normal levels two weeks after treatment. in the infected hamsters, praziquantel, at a curative dose, caused a tran ... | 1983 | 6318107 |
| relationship between prevalence and intensity of opisthorchis viverrini infection, and clinical symptoms and signs in a rural community in north-east thailand. | in a large village in north-east thailand, the overall prevalence of opisthorchis viverrini infection (based on stoll's quantitative egg count) was 89.5% in a total population of 1651 individuals. the prevalence was 32% in children under 5 years, 90% in those aged 5-9 years, and averaged 95.6% in age groups above 10 years. the mean faecal egg output (indicative of intensity of infection) was highest in the 40-49-year age group and remained relatively constant through older ages. in all age group ... | 1984 | 6331907 |
| liver carcinoma and liver fluke infection. | the neoplastic transformation of bile duct changes induced by infections due to clonorchis sinensis or opisthorchis viverrini has been persistently debated because of the difficulty to establish the causative relation between those trematode infections and the development of primary carcinoma of the liver (pcal) which has been found in hong kong, china, korea and thailand. the following observations, however, clearly support the hypothesis that clonorchiasis and opisthorchiasis are basic etiolog ... | 1984 | 6095876 |
| albendazole in the treatment of opisthorchiasis and concomitant intestinal helminthic infections. | a total of 52 adult patients with opisthorchiasis with or without concomitant intestinal helminthic infections were treated with albendazole at dosage regimens of 400 mg twice daily for 3 days (group i with 25 patients) and 7 days (group ii 27 patients). by concentration method with four examinations from two faecal specimens of each patient the cure rates and percentage egg reduction on day 30 in group i and group ii were 12% and 33%, 94 and 95 respectively; by stoll method the cure rates and p ... | 1984 | 6377514 |
| a clinical study of laotian refugees infected with clonorchis sinensis or opisthorchis viverrini. | twenty-six laotian refugees infected with clonorchis or opisthorchis liver flukes, and 15 uninfected controls, were assessed clinically by history, physical examination, serum 5'nucleotidase level, and serum immunoglobulin e level. ultrasound studies of the biliary tract were also done on a subset of six infected subjects. the results showed no differences between subjects and controls with respect to clinical symptoms, physical findings, 5'nucleotidase, or biliary ultrasound. mean serum ige lev ... | 1984 | 6391229 |
| therapy of fluke infections in the past. a review. | chemotherapy of trematode infections has been studied intensively in the past. the compounds so far used for the treatment of those parasitic infections were not satisfactory, however, because of their poor tolerability and/or their limited anthelmintic efficacy. since the introduction of tartar emetic in 1918, a number of antimonial as well as non-antimonial preparations have been used for the treatment of schistosomiasis. in the treatment of clonorchiasis with antimony preparations, gentian vi ... | 1984 | 6391498 |
| parasitological examinations and immunodiagnostic advances in fluke infections. | a reliable diagnosis of fluke infections should be based on the demonstration of parasite eggs in either faeces, duodenal liquid or sputum, depending on the type of infection. such an examination permits the identification of the species, and counting eggs establishes the intensity of infection. unfortunately this examination is useful only when intensity is rather high. the diagnosis of slight infections is uncertain and can vary considerably from one sample to another. in this area of parasito ... | 1984 | 6391499 |
| evaluation of selected anthelmintic compounds for activity against opisthorchis viverrini. | in vitro and in vivo experiments were employed in the screening of potential anthelmintic agents against opisthorchis viverrini infection in hamsters. a few selected groups of compounds tested included those that are commercially available as well as those that are still being tested by various pharmaceutical firms. the compounds tested in the present study were praziquantel, amoscanate, albendazole, flubendazole, metrifonate, metronidazole and benzodiazepine derivatives. results from both in vi ... | 1984 | 6464190 |
| treatment of opisthorchiasis viverrini in hamsters with albendazole. | efficacy of many drugs against opisthorchis viverrini in man were shown by the percentages of egg reduction and the absence of egg in faeces. in some cases, however, the eggs reappeared after a period of time. the pathological changes of the bile duct could cause partial or even complete obstruction of the bile passages, thus resulting in the occurrence of natural egg reduction. albendazole, a broad spectrum anthelmintic was used to treat opisthorchiasis viverrini in hamsters. at dosage of 100 m ... | 1984 | 6523174 |
| opisthorchis viverrini: life cycle, intermediate hosts, transmission to man and geographical distribution in thailand. | opisthorchis viverrini has been found to be the only species of liver fluke in thailand. the morphology is similar to that of o. felineus, but it has more deeply lobated testes, situated near the ovary. the appearance and distribution of the vitellaria with few granular clumps and the shorter and wider egg closely resemble that of c. sinensis. the adult worms live in the biliary system. eggs pass out in faeces. on reaching water the eggs are eaten by snails, the first intermediate host. in the s ... | 1984 | 6542383 |
| opisthorchis viverrini infection: pathogenesis and clinical features. | the pathological changes are more or less related to the intensity and the duration of the infection, and are commonly seen in older patients with a large number of flukes. the pathogenesis is due to the mechanical irritation by the flukes and some toxic substances produced by them. lesions are mainly confined to the biliary system. there is hyperplasia of the epithelial cells lining the bile ducts. in heavy and severe infections there are obstruction of the biliary tract, bile retention, extens ... | 1984 | 6542384 |
| some immunological aspects of opisthorchiasis. | information regarding the development of acquired immunity in opisthorchiasis is particularly relevant if one is attempting eradication of the disease, e.g. by anthelmintic chemotherapy. clinical observations in patients with opisthorchiasis suggest that if acquired immunity develops at all, it is of low degree. using hamsters as experimental model, it was recently demonstrated that prior infection with opisthorchis viverrini failed to confer protection against reinfection, regardless of the siz ... | 1984 | 6542385 |
| opisthorchis viverrini: clinical experience with praziquantel in hospital for tropical diseases. | praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino[2,1-a]++ +isoquinolin- 4-one, embay 8440, biltricide) has been used in 4853 patients with opisthorchis viverrini infection. 786 patients were treated as inpatients with extensive clinical evaluation and the rest were out-patients. a cure rate (evaluated with 5 faecal samples) of 100% was obtained in groups given 6 x 25 mg/kg on 2 days and 3 x 25 mg/kg on 1 day, while in groups given 2 x 25 mg/kg, 1 x 25 mg/kg and 1 x 40 mg/kg ... | 1984 | 6542386 |
| roentgenographically controlled healing of gallbladder lesions in opisthorchiasis after praziquantel treatment. | in a study, gallbladder lesions due to opisthorchis viverrini infection were controlled roentgenographically after treatment with praziquantel (2-cyclohexylcarbonyl-1,2,3,6,7,11b-hexahydro-4h-pyrazino[2,1-a] isoquinolin- 4-one, embay 8440, biltricide). the place of study was the khon kaen hospital, northeast thailand. included in the study were 20 patients with impairment of gallbladder function; 7 of them were males and 13 females. their age ranged from 27 to 60 years (mean 47.4), eggs per gram ... | 1984 | 6542387 |
| application of different paragonimus antigens to immunodiagnosis of human lung fluke infection. | utilizing enzyme immunoassay, paragonimus africanus, p. uterobilateralis, p. ecuadoriensis and p. westermani antigens were tested with regard to their reactivity to sera from patients infected with paragonimus africanus, p. uterobilateralis, p. ecuadoriensis, fasciola hepatica, opisthorchis viverrini, different schistosomes, cysticercus cellulosae, nematodes and from patients with nonparasitic diseases as well as from healthy blood donors. simultaneous application of paragonimus antigens to each ... | 1984 | 6542396 |
| a pilot project for controlling o. viverrini infection in nong wai, northeast thailand, by applying praziquantel and other measures. | in a pilot control project of opisthorchis viverrini in the village of nong wai irrigation area, khon kaen, northeast thailand, selected population based chemotherapy with a single dose of 40 mg/kg of praziquantel (2 - cyclohexylcarbonyl-1,2,3,6,7,11 b-hexahydro-4h-pyrazino [2,1-a]isoquinolin-4-one,embay8440,biltricide) was given to the stool positive cases once a year for a period of 3 years commencing may 1981. two villages (pop 942) with a prevalence of 58.3% were used as tests villages and a ... | 1984 | 6542402 |
| alterations of the surface tegument of opisthorchis viverrini exposed to praziquantel in vitro and in vivo. | the in vitro and in vivo effects of praziquantel on the ultrastructural surface of opisthorchis viverrini were investigated using scanning electronmicroscopy. for the in vitro study, adult flukes were collected from experimentally infected hamsters, and were incubated for various time intervals at 37 degrees c in earle's basal medium containing praziquantel at final concentrations of 0.01-100 micrograms/ml. for the in vivo study, flukes were collected from the biliary system of experimentally in ... | 1984 | 6740385 |
| studies on the chemotherapy of human opisthorchiasis: effective dose of praziquantel in heavy infection. | ninety-six patients who had heavy opisthorchis viverrini infection were studied. egg count per gram of faeces ranged from 10,800 to 139,000 (mean 26,044.3). praziquantel 50 mg per kg body weight was given after a morning meal. 68 patients completed the follow up period of 60 days. the cure rate was 97.0%. the side-effects occurred in 61 patients (89.7%). the common side effects were diarrhoea, dizziness, sleepiness, epigastric pain, headache, nausea and anorexia. these side-effects were mild and ... | 1985 | 3906918 |
| serum glutamyl transferase and other liver function tests in opisthorchis viverrini infection. | serum glutamyl transferase (gamma-gt), serum total protein, albumin, aspartate aminotransferase (got), alanine aminotransferase (gpt), alkaline phosphatase and bilirubin were measured in 55 males and 45 females suffering from o. viverrini infection and in apparently healthy non-infected individuals. a decrease in total protein, albumin and bilirubin, as well as an increase in got, gpt and gamma-gt was observed in males with o. viverrini infection, whereas alkaline phosphatase remained unaffected ... | 1985 | 2860715 |
| hemobilia and liver flukes in a patient from thailand. | a patient from southeast asia presented with abdominal pain, fever, jaundice, and upper gastrointestinal bleeding of unknown origin. opisthorchis viverrini eggs were found in the stool and multiple hepatic filling defects were noted on liver scan and sonogram. endoscopic retrograde cholangiopancreatography revealed cholelithiasis and crescent-like filling defects in the biliary system. at surgery, the gallbladder was filled with clotted blood and pigmented stones. during t-tube drainage of the c ... | 1985 | 3996848 |
| incidence of endemic opisthorchis viverrini infection in a village in northeast thailand. | incidence, measured as the proportion of persons whose stools become positive within one year, was studied in endemic opisthorchis viverrini, the human liver fluke, in a northeastern thai village over a two-year period. incidence was higher in males than in females, especially in children under five years of age. it was at least 47% overall in the first year of the study, but declined to below 20% per year in the second. this is attributed to drying of a local water reservoir and decline in avai ... | 1985 | 4037181 |
| enzyme-linked immunosorbent assay for detection of opisthorchis viverrini infection. | antibodies to o. viverrini in the sera of people from endemic and non-endemic areas were investigated using indirect elisa technique. for the patients from the endemic area, 92.8% who passed eggs in the stool were found to be positive for o. viverrini antibody. in addition, 46.5% of the people who did not pass eggs in the stool were also found to have low titer of o. viverrini antibody. on the other hand only 2.4% of the people from the non-endemic area with other intestinal parasite infections ... | 1985 | 4071196 |
| unusual protein pattern of opisthorchis viverrini. | the proteins of homogenized adult opisthorchis viverrini were separated by polyacrylamide gel electrophoresis and isoelectric focusing in the presence of detergents. by far the most abundant component(s) had a mr of 18,000 to 19,000, represented about 47% of the total parasite protein, and did not separate in isotypes. | 1985 | 4093591 |
| clinical features in severe opisthorchiasis viverrini. | clinical features of severe opisthorchiasis were studied in 88 patients. the ratio of males to females was 6.3 : 1; 75% were over 40 years old. the presenting symptoms were obstructive jaundice, 25% associated with secondary infection of biliary system; cholangitis and cholecystitis; intraabdominal mass, which was enlarged liver; 18% had palpable gallbladder; 18% had adenocarcinoma of the bile duct. high bilirubin was found in 46% of cases, high alkaline phosphatase in 80%; elevation of serum tr ... | 1985 | 4095605 |
| report of episthmium caninum (verma, 1935) yamaguti, 1958 (digenea: echinostomatidae) in man. | the first finding of episthmium sp. in man is reported. characteristics of the worm are given in detail. the infestation is an accidental one acquired from consuming raw fish, which serves as an intermediate host of opisthorchis viverrini. the pathogenic role of episthmium sp. in man needs further investigations. | 1985 | 4095615 |
| opisthorchis viverrini infection and cholangiocarcinoma. a prospective, case-controlled study. | during a prospective, 24-mo case-controlled study, 551 patients from northeastern thailand were independently evaluated for opisthorchis viverrini infection, hepatobiliary tract disease, and hepatic carcinoma to determine whether there was any association between hepatic carcinoma and o. viverrini infection. stool examination by the formalin-ether concentration method revealed o. viverrini ova in 389 (70.6%) patients. of the 551 patients, 72 (13.1%) had both clinical and laboratory evidence of h ... | 1985 | 2989071 |
| opisthorchis viverrini infection and cholangiocarcinoma. | 1985 | 2996965 | |
| cholangiocarcinoma associated with liver fluke infection: a preventable source of morbidity in asian immigrants. | in the far east infection with the liver flukes clonorchis sinensis and opisthorchis viverrini is the most frequently documented cause of cholangiocarcinoma. liver fluke infection in the united states remains a health problem for more than 500,000 southeast asian refugees who have immigrated to this country since 1975. recent surveys have revealed that up to 26% of asian immigrants have an active liver fluke infection. however, the common clinical manifestations of this condition, as well as the ... | 1986 | 3002170 |
| scanning electron microscopic study of opisthorchis viverrini tegument and its alterations induced by amoscanate. | 1986 | 3699972 | |
| complement-mediated killing of opisthorchis viverrini via activation of the alternative pathway. | 1986 | 3744673 | |
| field studies on the transmission of the human liver fluke, opisthorchis viverrini, in northeast thailand: population changes of the snail intermediate host. | 1986 | 3781736 | |
| opisthorchis viverrini: pathogenesis of infection in immunodeprived hamsters. | opisthorchis viverrini infections were established in immunologically intact and t cell deprived hamsters. t cell deprivation appeared to have no effect on worm establishment or egg production. histopathologically, intact and deprived animals showed similar degrees of bile duct hyperplasia and periductular fibrosis, though there was a marked reduction in the intensity of the periportal inflammation in the majority of t cell deprived animals. serum transaminase levels were significantly raised in ... | 1986 | 3490651 |
| immunization of hamsters against opisthorchis viverrini infection. | attempts were made to induce acquired immunity against opisthorchis viverrini infection in hamsters by immunizing them with aqueous somatic extract and metabolic products of adult worms, crude adult worm homogenates and metacercarial somatic extracts via either the intraperitoneal or combined intraperitoneal and oral routes. these procedures failed to stimulate significant protective response in animals that had never been exposed to o. viverrini. however, the protective response reached a signi ... | 1986 | 3576286 |
| types of collagen in opisthorchis viverrini infected hamster liver. | levels and types of collagen from normal and opisthorchis viverrini infected hamster livers were compared. normal liver contained approximately twice as much type i collagen than type iii collagen. upon infection by o. viverrini, both type i and type iii collagen were elevated, but the increase in type iii was proportionately larger than type i collagen. of the 3-fold increase in total collagen content of infected livers, type i and type iii collagen increased 2- and 4-fold, respectively. as a r ... | 1986 | 3960058 |
| immunodepression in hamsters experimentally infected with opisthorchis viverrini. | hamsters experimentally infected with opisthorchis viverrini had significant depression of the antibody response to sheep red blood cells. the depression was more severe with prolonged infections. lymphoproliferative response to phytohaemagglutinin stimulation was also depressed when compared with uninfected controls. the immunodepression in these animals was abolished by anthelmintic treatment, suggesting that the immunodepressive effect is reversible and is associated with active infection. | 1987 | 3611709 |
| measurement of incidence of the human liver fluke, opisthorchis viverrini, in northeast thailand. | a survey of a community in northeast thailand where opisthorchis viverrini is endemic permitted comparison of two methods of measuring incidence: direct determination of the rate at which an uninfected group became infected between two surveys a year apart, and estimation of incidence from age-specific prevalence data using a logarithmic regression method. both methods revealed that incidence increased with age in young children, and estimation from age-prevalence data showed that the increase w ... | 1987 | 3617199 |
| enhancement of den-induced hepatocellular nodule development by opisthorchis viverrini infection in syrian golden hamsters. | the influence of opisthorchis viverrini liver fluke infection on development of diethylnitrosamine (den)-induced hepatocellular nodules was investigated in syrian golden hamsters. infection with 60 metacercariae, 4 weeks prior to administration of den for 12 weeks in the drinking water at dose levels of 10, 20 and 40 p.p.m., resulted in a significantly increased yield of nodular lesions as compared with the group receiving carcinogen treatment alone. the results indicate an importance for parasi ... | 1987 | 3621473 |
| high urinary excretion of nitrate and n-nitrosoproline in opisthorchiasis subjects. | about 50% of the population in some provinces of north-east thailand are infested with liver fluke (opisthorchis viverrini), and many develop cholangiocarcinoma subsequently. this study was designed to demonstrate possible endogenous formation of n-nitrosoproline (npro) in this population. diet samples, saliva and urine were taken from subjects with and without liver fluke and analysed for nitrate and nitrite; urine was also analysed for npro. nitrate and nitrite levels in saliva were higher in ... | 1987 | 3679440 |
| opisthorchis viverrini infection in rural and urban communities in northeast thailand. | the prevalence and intensity of liver-fluke (opisthorchis viverrini) infection were investigated among 559 patients who were born in, and had lived all their lives in, either the rural or urban northeastern thailand. 344 (79.4%) of 433 rural dwellers were infected compared with only 69 (54.8%) of 126 urban dwellers (p less than 0.005). the intensity of infection, and the reported level of consumption of koi-pla, a favourite dish of local inhabitants prepared from uncooked freshwater fish which o ... | 1987 | 3686637 |
| level of opisthorchis infestation and carcinogen dose-dependence of cholangiocarcinoma induction in syrian golden hamsters. | the relationship between different levels of liver fluke, opisthorchis viverrini infestation and dimethylnitrosamine (dmn) dosage in the induction of cholangiocarcinomas was investigated in syrian golden hamsters. two hundred and eighty male, weanling animals were divided into 4 groups: group 1 served as untreated controls; group 2 received o. viverrini metacercariae only at levels of 100, 50, 25 or 12 per animal; group 3 received dmn only at doses of 12.5, 6.25 or 3.125 ppm; group 4 received va ... | 1987 | 2892303 |
| peritoneoscopic findings in 203 patients with opisthorchis viverrini infection. | a study was conducted to determine the value of peritoneoscopy in the diagnosis of opisthorchiasis. peritoneoscopic findings in 203 proven cases of opisthorchis viverrini infection are presented. the authors found that cholangiocarcinoma is frequently encountered in patients presenting with prolonged jaundice and hepatomegaly as well as with the peritoneoscopic findings of dilated superficial intrahepatic bile ducts, a bile-stained liver surface and a markedly enlarged gallbladder. | 1987 | 2951293 |
| analysis of opisthorchis viverrini antigens: physicochemical characterization and antigen localization. | antigens of opisthorchis viverrini were identified and characterized by enzyme-linked immunosorbent assay, polyacrylamide gel electrophoresis following radioimmuno-precipitation, and indirect immunofluorescence. the immunoreactive protein with a relative molecular weight (mr) of 89 kd was the predominating component of the parasite metabolic products. an immunofluorescence study showed it to be associated with parasite eggs, linings of the reproductive system and secretions therein. protein of t ... | 1987 | 3329412 |
| characterization of humoral immune response in the serum and bile of patients with opisthorchiasis and its application in immunodiagnosis. | the humoral immune response in patients with opisthorchiasis was investigated using an enzyme-linked immunosorbent assay. igg antibody reactive with opisthorchis viverrini antigens was present in the serum of all patients. the infection also stimulated specific iga and ige antibody responses in most patients and, in practically all patients, there was a marked increase of total ige. there was a moderate but significant correlation between serum igg antibody level and severity of infection as jud ... | 1988 | 3354768 |
| analysis of opisthorchis viverrini antigens by immunoprecipitation and polyacrylamide gel electrophoresis. | antigenicity of adult opisthorchis viverrini, metacercariae and eggs was investigated by radio-immunoprecipitation and polyacrylamide gel electrophoresis using sera from patients with opisthorchiasis and from hamsters experimentally infected with o. viverrini metacercariae. 125i-labelled aqueous somatic extract and in vitro metabolic products of adult worms, and the extracts of metacercariae and eggs were immunoprecipitated, electrophoresed and autoradiographed and major antigens were characteri ... | 1988 | 3362572 |
| enhancement of dhpn induced hepatocellular, cholangiocellular and pancreatic carcinogenesis by opisthorchis viverrini infestation in syrian golden hamsters. | infection with 100 opisthorchis viverrini (op) metacercariae prior to two injections of dihydroxy-di-n-propyl nitrosamine (dhpn) (1000 mg/kg body weight) brought about significant enhancement of resultant preneoplastic lesion development in syrian hamster liver and pancreas tissue. thus combined treatment with carcinogen and parasite was associated with pancreatic atypical (dysplastic) foci, hepatocellular nodules, cholangiofibrosis and cholangiocarcinomas. no such lesions were observed in carci ... | 1988 | 2836105 |
| generation of high yields of syrian hamster cholangiocellular carcinomas and hepatocellular nodules by combined nitrite and aminopyrine administration and opisthorchis viverrini infection. | combined administration of 0.1% nitrite and 0.1% aminopyrine in the drinking water for eight to ten weeks resulted in subsequent development of both hepatocellular nodules and cholangiofibrotic lesions/cholangiocellular carcinomas in syrian golden hamsters. additional prior dosing with opisthorchis viverrini metacercariae (100/animal) induced inflammatory and proliferative changes in the livers of infected hamsters and was associated with a significant increase in yields of hepatocellular and ch ... | 1988 | 2846484 |
| detection of antibodies against opisthorchis viverrini in patients before and after treatment with praziquantel. | levels of antibody in sera of 78 patients with opisthorchiasis, 30 patients with other liver diseases, 10 patients with schistosomiasis and 30 healthy individuals were compared using three serodiagnostic tests, namely indirect haemagglutination (iha), enzyme-linked immunosorbent assay (elisa) and lectin immuno test (lit). the geometric mean reciprocal titer in sera of opisthorchiasis patients was significantly higher than patients with other diseases, patients with schistosomiasis and healthy in ... | 1988 | 3136551 |
| rate of re-infection by opisthorchis viverrini in an endemic northeast thai community after chemotherapy. | 1988 | 3170073 | |
| antibodies in serum and bile of hamsters experimentally infected with opisthorchis viverrini. | 1988 | 3192345 | |
| a characteristic immunoblotting pattern for opisthorchiasis sera with metacercarial antigens. | the protein compositions of homogenized metacercaria and adult opisthorchis viverrini were characterized by sodium dodecyl sulphate polyacrylamide gel electrophoresis (sds-page). the two different stages of o. viverrini parasite contained several protein components with very similar mobilities on sds-page gel. the reaction in immunoblots of sera from patients with opisthorchiasis demonstrated antibodies against heterogeneous protein components of metacercariae and adult o. viverrini parasites. o ... | 1988 | 3233789 |
| opisthorchis viverrini eggs and adult flukes as nidus and composition of gallstones. | three cases of opisthorchiasis with calculous cholecystitis was presented. the diagnosis of gallstones was made before praziquantel therapy in 2 cases, and 4 years after treatment in one case. the patients underwent cholecystectomy. numerous o. viverrini eggs and one dead fluke were found in the bile in one case. a single stone was recovered from each gallbladder. all stones contained o. viverrini eggs. fragments of flukes were also present in two cases. the stones consisted of a mixture of bili ... | 1988 | 3238475 |
| density-dependent fecundity of opisthorchis viverrini in humans, based on faecal recovery of flukes. | 1989 | 2609378 | |
| human pathology of opisthorchis viverrini infection: a comparison of adults and children. | the pathology of human opisthorchiasis in 22 adults (20 to 68 years) and 7 children (7 to 15 years) at autopsy is described. the changes of the liver in adults and children are similar and are summarized as follows: enlargement of the liver was a common finding. pericholangitis was observed in most cases. the pathology was confined to the large and medium-sized bile ducts where the flukes inhabited. the small interlobular bile ducts had minimal or unremarkable changes. dilatation of the bile duc ... | 1989 | 2772709 |
| a high incidence of liver cancer in khon kaen province, thailand. | based on a population-based cancer registry in khon kaen province, thailand, data were collected actively and passively from all hospitals, health centers and the office of the chief medical officer of khon kaen. the data were collected prospectively for the year 1988 and retrospectively for the years 1985-1987. liver cancer, especially cholangiocarcinoma, was the leading cancer in both sexes. the age-standardized incidence rates for the year 1988 were 89.2/10(5) in males and 35.5/10(5) in femal ... | 1990 | 1963706 |
| detection of shared antigens of human liver flukes opisthorchis viverrini and its snail host, bithynia spp. | the relationship between opisthorchis viverrini and its snail intermediate host including bithynia funiculata, b. siamensis siamensis and b. siamensis goniomphalos was carried out on the correlation of shared antigens and infection rates. b. funiculata and b. s. siamensis were equally susceptible to o. viverrini with relatively high infection rates of 72.2% and 69.9% respectively whereas b. s. goniomphalos gave lowest percentage of infection of only 9.6%. by immunoelectrophoresis, crude extract ... | 1990 | 2075387 |
| occurrence of some medically important flukes (trematoda: opisthorchiidae and heterophyidae) in nam ngum water reservoir, laos. | occurrence of some medically important flukes transmitted to man by eating of raw fish was observed at 18 localities of nam ngum water reservoir, an important source of fish for inhabitants of vientiane province, laos. cercariae of opisthorchis viverrini were recorded in 0.9% of bithynia siamensis goniomphalus examined but in the most populated sites, where the density of the snails was the highest up to 2.2% of the intermediate hosts were infected. haplorchis cercariae were found in 2.0% of tar ... | 1990 | 2075492 |