Publications

the nutritive value of some legumes; lathyrism in the rat; the sweet pea, lathyrus odoratus, lathyrus sativus, lathyrus cicera and some other species of lathyrus.		1948	18892935
scoliosis and dissecting aneurysm of the aorta in rats fed with lathyrus odoratus seeds.		1952	12985834
production of dissecting aneurysms in rats fed lathyrus odoratus.		1954	13205214
lesions of the skeleton and of other mesodermal tissues in rats fed sweet-pea (lathyrus odoratus) seeds.		1954	13211697
resorption of embryos in rats on lathyrus odoratus diet.		1956	13295843
gravimetric detection of resorption of embryos in rats on lathyrus odoratus diet.		1957	13406618
elastic fiber alterations in rats treated with lathyrus odoratus; histopathologic study of elastic cartilage and of elastic fibers in arteries and membranes, with special reference to the occurrence of extra-aortic dissecting aneurysms.		1957	13457601
the effects of various levels of sweet peas (lathyrus odoratus) in the diet, with protein and amino acid supplementation, on the alveolar bone of young rats.		1959	13674687
the effects of various levels of sweet peas (lathyrus odoratus) in the diet, with and without dietary supplements, on the growth of the mandibular ramus and articulation in young rats.		1959	13826514
early skeletal and vascular changes in rats fed on sweetpea (lathyrus odoratus) seeds.		1959	13848789
morphologic and histochemical studies of skeletal lesions in rats fed sweet pea (lathyrus odoratus) seeds.		1960	13826512
naturally occurring toxic factors in plants and animals used as food.	toxic components of natural foodstuffs are discussed, with special reference to lathyrogens, pressor amines, azoxyglycosides, and labile sulfur compounds. the osteolathyrogen, gamma-glutamyl-beta-aminopropionitrile, in sweet pea (lathyrus odoratus) seeds induces skeletal deformities and aortic rupture, probably by interfering with normal maturation of collagen fibres. neurolathyrism in man may be caused by beta-n-oxalyl-l-alpha,beta-diaminopropionic acid, a neurotoxin recently identified in lath ...	1966	5905948
trehalase: a new pollen enzyme.	pollen from 5 plant species (lycopersicon pimpinellifolium mill., hermerocallis minor mill., galtonia condicans decne., camellia japonica l., and lathyrus odoratus l.) representing 4 families germinated well in media containing trehalose as the sole carbon source. data are presented indicating that pollen metabolized this disaccharide for germination and subsequent pollen-tube growth; the sugar was not merely an osmoregulator. an inhibitor of trehalase activity depressed germination in trehalose ...	1969	5379538
changes in facial structures of rats caused by supplements of vitamin a and lathyrus odoratus.		1973	4511312
lathyrogenic activity of 2 (2-cyanoethyl)-3-isoxazolin-5-one from lathyrus odoratus seedlings.		1974	4442514
the oxytalan fiber system in the mandibular periodontal ligament of the lathyritic mouse.	experimental lathyrism was produced in young albino mice with a diet containing 50% sweet pea seed (lathyrus odoratus). after 7 days on the lathyritic diet, sections of themandibular molar and incisor periodontal ligaments, when oxidized and treated with aldehyde fuchsin, demonstrated enhanced staining of the oxytalan fibers and numerous vessels. at this time aldehyde fuchsin or orcein also revealed marked pathological changes in the periodntal ligament of all molars. when athyrism was prolonged ...	1977	69701
isolation and partial characterization of a mitogenic lectin from lathyrus odoratus seeds.	a mitogenic lectin has been isolated from saline extract of lathyrus odoratus seeds by (nh4)2so4 precipitation and subsequent chromatography on deae-sepharose and cm-sepharose. the isolated lectin was almost homogeneous by sds gel electrophoresis and gel filtration, but multiple bands were obtained on isoelectric focusing. the molecular weight, determined by gel filtration, was 37,000. gel electrophoresis in the presence of sds gave a molecular weight of 19,000, thus suggesting that the lectin i ...	1978	716928
mitogenic stimulation of human lymphocyte subpopulations by lathyrus odoratus lectin.	investigation was made of the mitogenic activation by lathyrus odoratus (lath) lectin and phytohaemagglutinin (pha) of human t-enriched and non-t lympohcytes isolated by nylon wool filtration and sheep erythrocyte rosette depletion, respectively. lath stimulated only weakly the t-enriched and non-t fractions as compared to pha which strongly stimulated the t-enriched population and weakly stimulated the non-t cells. removal of phagocytic cells from the unfractionated lymphocytes caused only a sl ...	1979	315154
studies on lectins. xlviii. isolation and characterization of lectins from the seeds of lathyrus odoratus l. and lathyrus silvestris l.	lectins from seeds of lathyrus odoratus l. and lathyrus silvestris l. were isolated by (nh4)2so4 precipitation and affinity chromatography on sephadex g-150. both lectins were found to be homogenous by ultracentrifugation (s20,w for the l. odoratus lectin was 3.29, for the l. silvestris lectin 3.39) and by discontinuous polyacrylamide gel electrophoresis in alkaline and acidic buffer systems. the amino acid composition of both lectins is characterized by high contents of aspartic and glutamic ac ...	1980	7456927
novel evolutionary variation in transcription and location of two chloroplast genes.	we have found major evolutionary changes in the types of transcripts produced by specific chloroplast genes, in particular those encoding the large subunit (ls) of ribulose-1,5-bisphosphate carboxylase and a photosystem ii polypeptide (pii). two distinct patterns of ls gene transcripts are revealed by hybridizing an ls gene probe to electrophoretically separated rna from 19 angiosperms. most species, including pea, contain the single transcript of approximately 1.6 kb previously observed in corn ...	1982	6757868
interactions of purified human ceruloplasmin with lathyrus odoratus, lens culinaris and canavalia ensiformis lectins.	human ceruloplasmin was isolated from normal serum by fractional polyethylene glycol precipitation and subsequent ion exchange chromatography. the molecular mass determined by ultracentrifugation was 132 kda and an optical density ratio (a610/a280) of 0.046 was observed in the preparation. immunoelectrophoresis, agarose-gel electrophoresis and n-terminal amino-acid sequence analyses showed that the ceruloplasmin preparation was highly purified, while dodecyl sulphate polyacrylamide-gel electroph ...	1983	6840700
lathyrism: a neurotoxic disease.	lathyrism, one of the oldest neurotoxic diseases known to man, results from excessive consumption of the chickling pea, lathyrus sativus, and certain related species. once prevalent throughout europe, n. africa, middle east and parts of the far east, the disease is presently restricted to india, bangladesh and ethiopia. lathyrism is a form of irreversible, non-progressive spastic paraparesis associated with poorly understood degenerative changes in spinal cord. domestic animals, notably the hors ...	1983	6422318
antigenic similarities both inside and outside the carbohydrate-binding sites of two-chain and one-chain leguminous lectins.	antibodies were made against the two-chain lectin lath-o from the seeds of lathyrus odoratus as well as its isolated light (alpha) and heavy (beta) chains. these antibodies were used to antigenically compare the lath-o with other two-chain lectins like lath-s, lentil and vicia cracca glc specific and with one-chain lectins like con a, pha, peanut and soybean. sensitive elisa tests showed that there was a distinct antigenic cross-reaction between the one-chain and two-chain lectins both by using ...	1984	6424408
considerations of copper metabolism in osteochondrosis of suckling foals.	of 8 thoroughbred foals in which osteochondrosis developed before weaning, 7 had serum copper and ceruloplasmin concentrations below normal. three foals on one farm had serum zinc content high enough to suggest zinc toxicosis, and the liver of each foal contained abnormally high content of zinc. four foals from the second farm had extremely low serum copper content, but normal serum zinc content. evidence of environmental exposure to excess zinc was not found on either farm. the lesions in the z ...	1984	6746386
periosteal stimulation by artificial tension.	the role of tension in the formation of exostoses in lathyritic rats was studied by applying artificial tension to the tendon of insertion of the adductor longus muscle. exostoses were formed in the periosteum at the insertion site in rats fed a 50% lathyrus odoratus diet, given artificial tension and a normal diet, and given artificial tension and a lathyrus diet. the latter were the largest. it is concluded that tension plays an important role in the formation of lathyritic exostoses and that ...	1985	3842143
muscle function studies in amputated lathyritic rats.	this study is presented to compare two methods of evaluating changes in muscle function after amputation of the left leg at the knee. rats were fed a 50% lathyrus odoratus diet, which causes exostoses to develop at sites of attachment of certain muscles. the rats were on the experiment for 3, 6, or 9 weeks. muscles of rats killed at 6 weeks were weighed to determine whether atrophy or hypertrophy had occurred. sizes of exostoses were evaluated subjectively at each time period. the left adductor ...	1985	3973552
effects of dietary butylated hydroxyanisole and cysteine on toxicity of lathyrus odoratus to broiler and japanese quail chicks.	the effect of .75% dietary butylated hydroxyanisole (bha) and 1% cysteine on the toxicity of lathyrus odoratus seed to japanese quail and broiler chicks was examined. in both species, the feeding of lathyrus seed as a component of a complete diet depressed (p less than .05) body weight gain and feed intake. typical signs of lathyrism, including ruffled feathers, enlarged hocks, curled toes, ataxia, leg paralysis, and mortality, were observed. neither bha nor cysteine exerted protective effects a ...	1988	3375172
flowering and branching in lathyrus odoratus l.: loci sp and b.	a second flowering gene, sp, which influences sensitivity to photoperiod, is identified in the sweet pea, lathyrus odoratus l. genes sp and dn (h) act in a complementary manner to confer the summer-flowering phenotype and a near obligate long day requirement for flowering in the unvernalized state. mutations sp and dn (i) each diminish the response to photoperiod, and genotypes sp dn (h) and sp dn (i) confer a spring-flowering phenotype. response to photoperiod is further reduced in genotype sp ...	1988	24232408
differences in the lectin-binding patterns of the periportal and perivenous endothelial domains in the liver sinusoids.	we have studied the distribution patterns of carbohydrate terminals on the endothelial surface of the mouse liver microvasculature. for this purpose, a wide battery of fitc lectins specific to glucose, mannose, galactose, fucose, n-acetyl-neuraminic acid, n-acetyl-galactosamine and n-acetyl-glucosamine residues were incubated on liver cryostat sections or intraportally perfused under physiological conditions. all the resulting hepatic sections were examined under fluorescent microscopy and confo ...	1991	1906044
salivary gland surface carbohydrate variations in three species of the anopheles gambiae complex.	fluorescein isothiocyanate (fitc)-conjugated lectins (agglutinins) were employed as probes to distinguish between the various carbohydrates present on the surface of salivary glands of three species of mosquito of the anopheles gambiae complex. of twenty lectins tested, eight (concanavalin a- con a, lathyrus odoratus- loa, lens culinaris, pisum sativum-psa, vicia faba- vfa, triticum vulgaris, maclura pomifera- mpa and ulex europaeus) specifically reacted with the salivary gland membrane. both ma ...	1993	8279867
gibberellin-photoaffinity labelling of two polypeptides in plant plasma membranes.	two polypeptides of m(r) 68 kda and 18 kda were gibberellin (ga)-photoaffinity labelled in vitro in plasma membrane preparations from oat (avena sativa l.) aleurone and from leaves and stems of wild-type and ga-sensitivity mutants of different species. labelling of these polypeptides could be competed by biologically active, but not by inactive, gas, indicating the likely biological significance of these interactions. on 2-dimensional gels the radiolabelled polypeptides were each resolved as one ...	1998	9750344
localized hypermutation and associated gene losses in legume chloroplast genomes.	point mutations result from errors made during dna replication or repair, so they are usually expected to be homogeneous across all regions of a genome. however, we have found a region of chloroplast dna in plants related to sweetpea (lathyrus) whose local point mutation rate is at least 20 times higher than elsewhere in the same molecule. there are very few precedents for such heterogeneity in any genome, and we suspect that the hypermutable region may be subject to an unusual process such as r ...	2010	20978141
reactivity with legume lectins of three monoclonal antibodies made against the lathyrus odoratus lectin.	three murine igg1 monoclonal antibodies (moab) were produced against the glucose/mannose-specific two-chain mitogen from seeds of lathyrus odoratus (sweet pea) belonging to the vicieae tribe of the leguminosae family. their antigenic specificities were tested against subunits of two-chain and one-chain legume lectins separated by sodium dodecyl sulphate-polyacrylamide gel electrophoresis and electrotransferred to nitrocellulose filters. different binding to native and detergent-treated lectins i ...	2011	3166740
flower power: its association with bee power and floral functional morphology in papilionate legumes.	a test was made of the hypothesis that papilionate legume flowers filter pollinators according to their ability to exert strength to open flowers to access rewards. in addition, interactions with pollen vectors were expected to explain the structural complexity of the architecture of these flowers since operative flower strength may be determined by a combination of morphological traits which form part of an intrafloral functional module.	2011	21821623