Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| factors influencing pathogenicity of mycoplasma arthritidis (pplo). | 1963 | 13955157 | |
| [polyarthritis in rats induced by mycoplasma arthritidis. 3. characteristics; role of "peri-pneumonia-like organisms"]. | 1964 | 14210547 | |
| [experimental polyarthritis in rats induced by mycoplasma arthritidis. iv. immunological phenomena (animals subjected to active immunization)]. | 1964 | 14210563 | |
| [polyarthritis in rats caused by mycoplasma arthritidis. i. experimental reproduction]. | 1964 | 14234563 | |
| [polyarthritis in rats caused by mycoplasma arthritidis. ii. role of various factors]. | 1964 | 14234573 | |
| [experimental polyarthritis in rats induced by mycoplasma arthritidis. v. immunological phenomena. action of passive immunization]. | 1964 | 14250551 | |
| characterization of mycoplasma strains from cats. | mycoplasma strains (b1, b2, cs, and s1a) were isolated from the saliva of normal cats. these were compared with a strain (co) isolated from the eye of a cat with severe conjunctivitis. on the basis of morphology, biochemical reactions, and antigenic composition, two distinct species were recognizable. strains co, b1, and b2 were antigenically unrelated to the other species tested; strains cs and s1a possessed antigenic components in common with mycoplasma arthritidis, m. salivarium, m. hominis, ... | 1967 | 4168314 |
| a comparative study on the virulence of mycoplasma arthritidis and "mycoplasma hominis, type 2" strains in rats. | 1967 | 6017752 | |
| immunological responses of the rat to mycoplasma arthritidis. | arthritis was produced in rats by the intravenous injection of mycoplasma arthritidis. metabolic inhibiting antibody and indirect hemagglutinating antibody could not be detected in the sera of arthritic or convalescent animals. nonmurine species of mycoplasma were capable of inducing metabolic inhibiting antibody in the rat. a hypothesis based upon the possible occurrence of heterogenetic antigens common to m. arthritidis and rat tissue was brought forward to explain these findings. complement-f ... | 1969 | 5305935 |
| effect of animal passage on arthritogenic and biological properties of mycoplasma arthritidis. | determinations of the ed(50) of cultures of mycoplasma arthritidis disclosed the existence of great diversity in the arthritogenic properties of the various strains. in most cases, the ed(50) values were lowered after passaging in rats, and a more severe arthritis with a shorter period of onset was observed. heavy suspensions of arthritogenic m. arthritidis did not appear to induce any toxic symptoms. prior injections of endotoxin did not enhance the toxicity of m. arthritidis suspensions. the m ... | 1970 | 16557773 |
| immunological response of rodents to murine mycoplasmas. | mycoplasma arthritidis, m. pulmonis, m. neurolyticum, and m. felis strains administered on various immunization schedules induced complement-fixing and agglutinating antibodies in rats, mice, and guinea pigs. metabolic inhibiting (mi) antibodies against m. felis were produced by guinea pigs, mice, and rats. m. neurolyticum did not induce mi antibody in mice but induced high titers in guinea pigs and rats. m. pulmonis failed to induce mi antibody titers in mice, induced low titers in rats, and in ... | 1970 | 16557855 |
| role of biological mimicry in the pathogenesis of rat arthritis induced by mycoplasma arthritidis. | complement fixation (cf), immunofluorescence, and agar gel double-diffusion tests were used to demonstrate an antigenic relationship between rat tissues and mycoplasma arthritidis. rabbit antisera against six strains of m. arthritidis exhibited positive reactions in the cf test with an ethyl alcohol-saline extract of rat muscle, whereas only 6 of 18 antisera against other mycoplasma species were positive. with the use of gel diffusion techniques, absorption of various m. arthritidis antigens wit ... | 1971 | 16557942 |
| chronic proliferative arthritis of mice induced by mycoplasma arthritidis. ii. serological responses of the lost and effect of vaccines. | complement-fixing antibodies were first detected in mice 7 days after intravenous injection with mycoplasma arthritidis. peak titers were observed at 21 days, and high levels of antibody persisted through 293 days. the metabolism-inhibiting antibody response was minimal. on fractionation of mouse sera, only 7s antibody was detected which first appeared at 12 days after injection and persisted throughout the experiment. in contrast, serum taken from rats injected with m. arthritidis contained pre ... | 1971 | 5154890 |
| non-traumatic blood collection from rat tail vessels. application in mycoplasma arthritidis. | 1971 | 5158245 | |
| chronic proliferative arthritis of mice induced by mycoplasma arthritidis. i. induction of disease and histopathological characteristics. | mice injected intravenously with mycoplasma arthritidis developed a chronic arthritis which persisted through at least 269 days. rats similarly treated developed an acute short-term infection. the mouse disease was characterized by periods of remission and exacerbation and was proliferative in nature, gradually spreading to adjacent joints. m. arthritidis strain 158 p10 was found to be less arthritogenic for mice than for rats, but further passage of this strain in mice substantially increased i ... | 1971 | 5154887 |
| reproducible polyarthritis in rats caused by mycoplasma arthritidis. | 1971 | 5090248 | |
| proteolytic activity of mycoplasma arthritidis. | 1972 | 5071646 | |
| the effect of immunosuppression on polyarthritis induced by mycoplasma arthritidis in rats. | 1973 | 4731989 | |
| blood changes in experimental arthritis in two types of genetically different rats. | 1. rats genetically resistant to dextran and other agents producing the anaphylactoid reaction (nr rats), have a higher polymorph count than do rats which react to these agents (r rats).2. nr rats do not develop polyarthritis when a hind paw is injected intradermally with freund's adjuvant.3. the polyarthritis produced by an intravenous injection of mycoplasma arthritidis culture develops more slowly in nr rats than in r rats.4. it is not clear whether the higher polymorph count in nr rats is a ... | 1973 | 4788039 |
| [factors influencing the susceptibility of mice to mycoplasma arthritidis]. | concentrated broth constituents markedly enhanced the development of abscesses after subcutaneous injection of mycoplasma arthritidis. under appropriate conditions, both virulent and avirulent strains of m. arthritidis produced toxic effects in mice, as detected by the development of necrotic abscesses and death of the animals. the treatment of mice at birth with m. arthritidis antigens rendered the animals more susceptible to infection with m. arthritidis later in life, as evidenced by increase ... | 1973 | 4572611 |
| fate of intravenously injected mycoplasma arthritidis in rodents and effect of vaccines. | virulent mycoplasma arthritidis strain 158 p10 was rapidly eliminated from the peripheral circulation of rats and mice during the first 2 h after intravenous injection of the organisms. characteristically after this time, the numbers of viable organisms remained remarkably constant through 48 to 72 h. the inability to clear the remaining mycoplasmas was not due to reticuloendothelial blockade but appeared to indicate the presence of a certain number of cells which were resistant to the clearance ... | 1973 | 4713693 |
| interaction of mycoplasma arthritidis and other mycoplasmas with murine peritoneal macrophages. | neither mouse nor rat peritoneal macrophages were able to kill mycoplasma arthritidis to any observable degree in the absence of specific hyperimmune rabbit antiserum. although convalescent mouse and rat serum were somewhat inhibitory to m. arthritidis in the absence of macrophages, these sera did not promote active phagocytosis by peritoneal macrophages. in fact, the macrophages appeared to protect the mycoplasmas against the inhibitory effects of the antisera by stimulating their growth. hyper ... | 1973 | 4587519 |
| effects of salicylates on blood changes in mycoplasma arthritis in rats. | 1. the polyarthritis produced in rats by i.v. inoculation with mycoplasma arthritidis was made more severe by salicylates.2. the infection increased the erythrocyte sedimentation rate (esr), serum lysozyme, counts of total white blood corpuscles, polymorphonuclear cells and lymphocytes, haemolytic serum complement (ch 50) and its component c3. salicylates enhanced the rise in esr, ch 50 and c3, but suppressed the rise in lymphocytes and even induced a fall.3. salicylates did not interfere with t ... | 1973 | 4722043 |
| detection and characterization of defective mycoplasmacidal antibody produced by rodents against mycoplasma arthritidis. | a procedure has been developed for the detection of mycoplasmacidal antibody in the serum of rats and mice infected with mycoplasma arthritidis. antibody activity can apparently be measured only by using resting mycoplasma cells. the reaction is complement dependent and is usually complete within 3 h. early antibody (5 days) could be detected only within the immunoglobulin (ig)m fraction, whereas late antibody (42 days) is found within the igg fraction. the mycoplasmacidal antibody was highly sp ... | 1973 | 4125266 |
| studies on proteolytic activity of mycoplasmas: the preparation and properties of gelatinolytic enzymes from strains of mycoplasma arthritidis. | 1973 | 4356946 | |
| induction of interferon in mice by mycoplasmas. | interferon was induced in mice after intraperitoneal inoculation with four different mycoplasmas. peak levels of between 100 and 300 u of interferon per ml were attained by 6 h postinfection with each of the mycoplasmas except mycoplasma arthritidis, which induced higher titers (400 to 11,800 u/ml) by this time. a fifth mycoplasma, m. pulmonis, induced interferon inconsistently and at a later (72 to 96 h) time. mycoplasmatales virus mvl51 and sterile mycoplasmal broth did not stimulate interfero ... | 1974 | 4373395 |
| serological reactions of mycoplasma hominis: differences among mycoplasmacidal, metabolic inhibition, and growth agglutination tests. | seven strains of mycoplasma hominis from human genital tracts were selected to produce antisera. the complement-dependent mycoplasmacidal (mc) activity and two complement-independent activities, metabolic inhibition (mi) and agglutination during growth (ga), of these sera were compared. the ga and mi tests were equivalent in titer and generally not affected by concentration of antigen; they revealed specific cross-reacting patterns among the seven strains. there was little if any cross-reactivit ... | 1974 | 4473426 |
| serological comparison of five arginine-utilizing mycoplasma species by two-dimensional immunoelectrophoresis. | five arginine-utilizing, nonglycolytic mycoplasma species were compared serologically by two dimensional immunoelectrophoresis. the survey included: mycoplasma hominis, mycoplasma arthritidis, mycoplasma gateae, mycoplasma gallinarum, and three strains of mycoplasma arginini. although the m. arginini strains showed strong cross-reactions, each strain produced a different antigenic profile which was distinct and which indicated significant antigenic differences between strains. the m. arginini st ... | 1974 | 4473427 |
| stable mycoplasma antigen preparations for indirect hemagglutination tests. | in immunological studies of mycoplasmas, the use of glutaraldehyde for the fixative makes it possible to use erythrocytes from commercially available defibrinated sheep blood. it eliminates the necessity of having to screen blood from individual sheep to obtain a suitable source of erythrocytes, as when employing tannic acid for fixation and sensitization. the chemical bonding of soluble mycoplasma proteins to glutaraladehyde-fixed sheep erythrocytes by bis-diazotized 3,3'dimethoxy derivative, b ... | 1974 | 4207279 |
| mycoplasma-associated immunosuppression: effect on hemagglutinin response to common antigens in rabbits. | a mycoplasma-associated immunosuppression of the primary and secondary hemagglutinin response to a common gram-negative antigen of escherichia coli (014) was demonstrated in the rabbit when preincubated mixtures of common gram-negative antigen and mycoplasma arthritidis membranes were injected intravenously. a similar immunosuppression was demonstrated only for the secondary hemagglutinin response to a common gram-positive antigen of staphylococcus aureus when preincubated mixtures of common gra ... | 1974 | 4593344 |
| [clinical and histopathological findings in mycoplasmal polyarthritis of rats. ii. course of disease between the 2. and 6. week (authors transl)]. | between the 9th and 42nd day p.i. the clinical features and microbiological findings of rats infected intraperitoneally with mycoplasma arthritidis were recorded and a histological investigation was carried out. from the 12th day p.i. arthritic lesions clinically showed a gradual regression. until the 42nd day p.i. mycoplasmas and purulent exudate were present within the joint cavity. during the course of infection a gradual increase of mesenchymal cell activity was found, leading to the formati ... | 1975 | 1154907 |
| mycoplasma-mediated hyporeactivity to various interferon inducers. | three strains of mycoplasma arthritidis were shown to induce marked hyporeactivity in mice to interferon induction by both newcastle disease virus and poly(i:c). in contrast, the interferon response of mice to tilorone was only partially suppressed by pretreatment of the animals with mycoplasms. hyporeactivity to newcastle disease virus was maximal 1 and 3 days after mycoplasms treatment, but the interferon response was maximal 1 day after injection of the mycoplasmas and was no longer apparent ... | 1975 | 1205616 |
| the occurrence of mycoplasma arthritidis in the throat and middle ear of rats with chronic respiratory disease. | twenty-three rats with chronic respiratory disease were examined for the presence of mycoplasma arthritidis in the throat and middle ear. samples were taken at necropsy and swabbed onto an agar medium. morphologically typical colonies were subcultured and identified serologically. all of the rats showed evidence histopathologically of chronic respiratory disease, and typical m pulmonis colonies were isolated from 21 of 23. m arthritidis was isolated from 7 (30=) of the middle ears and 3 (13%) of ... | 1975 | 1207046 |
| chronic proliferative arthritis of mice induced by mycoplasma arthritidis: demonstration of a cell-mediated immune response to mycoplasma antigens in vitro. | lymphocytes taken from mice chronically infected with mycoplasma arthritidis exhibited a significant blastogenic response as measured by (3h)thymidine uptake when exposed in vitro to m. arthritidis antigens. the lymphocytes taken from 9 of 12 control mice of similar age exhibited an inhibition of (3h)thymidine uptake when exposed to m. arthritidis antigens. | 1975 | 1123254 |
| experimental polyarthritis in rats produced by mycoplasma arthritidis. | 1975 | 1092737 | |
| hematologic changes in chronic arthritis of mice induced by mycoplasma arthritidis. | the arthritis caused by iv injection of m. arthritidis in mice was found to be associated with neutrophilia and lymphopenia without a change in the total wbc concentration. a mild anemia developed which was characterized by hypoferremia and plentiful re iron but with an increased plasma total iron-binding capacity. this anemia therefore differs from the anemia of chronic disorders and indeed from any anemia which occurs in man. | 1975 | 1208586 |
| arthritis of mice induced by mycoplasma arthritidis. humoral antibody and lymphocyte responses of cba mice. | peak arthritis occurred 7 days after intravenous injection of cba mice with mycoplasma arthritidis and persisted in some animals for 84 days. a marked leucocytosis was apparent for the first 21 days. complement-fixing antibodies reached a peak 14 days after injection of the organisms and persisted at high levels for 84 days. metabolic-inhibiting and mycoplasmacidal antibodies were present but at much lower titres. | 1976 | 1275576 |
| role of arginine deiminase in growth of mycoplasma hominis. | arginine has been considered as the major energy source of nonglycolytic arginine-utilizing mycoplasmata. when three strains of mycoplasma arginini, and one strain each of mycoplasma arthritidis, mycoplasma fermentans, mycoplasma gallinarum, mycoplasma gallisepticum and mycoplasma hominis were grown in the medium with high arginine concentration (34 mm) compared with low arginine (4 mm), both the protein content of the organisms and the specific activity of arginine deiminase increased. m. ferme ... | 1976 | 1262306 |
| animal models of arthritis. | the criteria for selecting and establishing a animal model for arthritis were described. rats are the most frequently used animals. adjuvant and myocobacterium induced arthritis provide a model of chronic joint inflammation, although significant differences exist when compared with human disease. a better model of arthritis in rats and mice can be induced by the injection of one strain of mycoplasma arthritidis. an even better model is presented by rabbits first immunized against a protein such ... | 1976 | 818450 |
| mycoplasma-dependent activation of normal lymphocytes: role of arginine and nonviable mycoplasma antigen in the induction of lymphocyte-mediated cytotoxicity for syngeneic mouse target cells. | the ability of arginine supplementation to abrogate or potentiate mycoplasma arthritidis-mediated cytotoxicity induction by normal cba mouse lymphocytes was investigated. also, nonviable antigens of m. arthritidis were assayed for their ability to induce a cytotoxic response. the presence of additional arginine in the culture medium had no significant effect on the amount of cytotoxicity produced. in some cases, an increase in cytotoxicity was seen in the presence of additional arginine. amino a ... | 1977 | 562854 |
| mycoplasma-dependent activation of normal lymphocytes: induction of a lymphocyte-mediated cytotoxicity for allogeneic and syngeneic mouse target cells. | mycoplasma arthritidis, m. hominis, and m. arginini were tested for their ability to induce a cytotoxic response from normal cba mouse lymphocytes against 51cr-labeled allogeneic target cells. in most cases, the mycoplasmas alone were not toxic for the target cells. furthermore, the mycoplasmas did not result in decreased lymphocyte viability but, in fact, contributed to enhanced lymphocyte survival. in the absence of normal cba lymphocytes, mycoplasmas alone did not induce a significant amount ... | 1977 | 562853 |
| binding of sodium [195au]aurothiomalate to mycoplasma arthritidis. | the binding of sodium [195au]aurothiomalate (atm) to whole cells of mycoplasma arthritidis has been measured within the temperature range of 4 to 53 degrees c. the time course (kinetics) and the effect of varying the total concentration of free atm in the suspension at 37 degrees c were also measured. the extent of binding at 37 degrees c leveled off after 30 min at approximately 65 nci of [195au]atm per mg of membrane protein. the amount of atm bound per cell appeared to be directly proportiona ... | 1977 | 409687 |
| new models of chronic synovitis in rabbits induced by mycoplasmas: microbiological, histopathological, and immunological observations on rabbits injected with mycoplasma arthritidis and mycoplasma pulmonis. | a dose-dependent chronic synovitis was induced in rabbit knees after the intra-articular injection of both mycoplasma arthritidis and mycoplasma pulmonis. the inflammation progressed from an initial acute phase at 1 week characterized by edema, infiltration of the synovium with monocytes and heterophils, and desquamation of lining cells, to a more chronic phase at 1 and 3 months, in which villus hyperplasia, lymph "nodules," mononuclear cell infiltration, fibroplasia, and collagen deposition wer ... | 1977 | 873616 |
| arginine deiminase from mycoplasma arthritidis. evidence for multiple forms. | arginine deiminase (ec 3.5.3.6) from mycoplasma arthritidis atcc 14152 has been purified 6-fold by a new procedure, protamine sulfate fractionation and deae-agarose chromatography. the yield was 75 to 85%. the homogeneity of the final preparation was demonstrated by gel filtration, sodium dodecyl sulfate-gel electrophoresis, nh2-terminal analysis, and polyacrylamide gel electrophoresis at two ph values. the enzyme has a molecular weight of 80,000 as measured by gel filtration. the dimeric nature ... | 1977 | 856796 |
| arginine deiminase from mycoplasma arthritidis. properties of the enzyme from log phase cultures. | hydrodynamic, chemical, and optical properties of arginine deiminase (ec 3.5.3.6) from mycoplasma arthritidis are reported for the enzyme isolated from log phase cells. the s020,w and d020,w values of the enzyme are 5.48 s and 5.87 x 10(-7) cm3/s, respectively; the molecular weight is 87,300. determination of the amino acid composition shows that about 45% of the residues are nonpolar. another unique feature of the composition is the presence of 36 half-cystine residues. the state of oxidation o ... | 1978 | 681335 |
| arginine deiminase from mycoplasma arthritidis. structure-activity relationships among substrates and competitive inhibitors. | the arginine deiminase (l-arginine iminohydrolase, ec 3.5.3.6) from mycoplasma arthritidis catalyzes the irreversible hydrolysis of arginine and related guanidine derivatives to ammonia and the corresponding ureido analog of the substrate. the kinetic constants km, kcat, and kcat/km for the arginine deiminase-catalyzed hydrolysis of l-arginine are equal to 4 micron, 29 s-1, and 7.4 x 10(7) m-1 s-1, respectively, at 25 degrees c and ph 7.2. the enzyme also catalyzes the hydrolysis of l-canavanine ... | 1978 | 681336 |
| [structural study of mycoplasma by a scanning electron microscopy method]. | scanning electron microscopy was applied to the study of mycoplasma arthritidis, myc. gallisepticum, and acholeplasma laidlawii. small spherical elements (0.3--0.5 micrometer) formed a reticular "framework" of the colonies in which larger (1--1.5 micrometer) spheroid or irregular-shaped cells (in case of myc. gallisepticum) and also rod-shaped (1--3 micrometer), filamentous (3--5 micrometer) forms and "large bodies" (5 x 3--8 x 3.5 micrometer) were located. apparently the latter represented cong ... | 1978 | 747025 |
| mycoplasma infection in pregnant rats: low viability of foetuses and newborn offspring. | the controversy regarding the possible role of genital mycoplasma infection in human reproductive failure gave rise to a study in which pregnant rats, previously shown to be of normal fertility, were inoculated 7-11 days after conception with either mycoplasma arthritidis or an equal volume of sterile broth medium. repeated observations during the course of pregnancy revealed several pathogenic effects. a statistically significant decrease was observed in the mean litter size of infected mothers ... | 1978 | 682177 |
| [effect of mycoplasma arthritidis on mouse and rat lymphoid cells in experimental mycoplasma infection]. | early stages of mycoplasma infection of mice and rats were accompanied by suppression of the populations of rosette- and plaque-forming cells. later the character and dynamics of the immune response to m. arthritidis differed in mice and rats. in mice mycoplasma infection was accompanied by stimulation of rosette-forming cells with some suppression of the plaque-forming cells from the 7th to the 36th day of infection. in rats by the 7th day the number of plaque- and rosette-forming cells decreas ... | 1979 | 433504 |
| [comparative study of rosette and plaque formation in rats infected with mycoplasma arthritidis and acholeplasma laidlawii]. | m. arthritidis suppresses rosette- and plaque-formation in rats infected with this strain of mycoplasma. on the 15th day the immune response was restored in the control and experimental groups of animals. in later stages a strong stimulation of rfc and pfc was recorded, which levelled on day 150. on the contrary, a. laidlawii stimulated rfc and pfc in all stages of infection. a relationship between the phenomena described and pathogenic properties of the mycoplasma is discussed. | 1979 | 380687 |
| [action of mycoplasma arthritidis and acholeplasma laidlawii on the immunological reactivity of balb/c mice infected with the rauscher leukemia virus]. | 1979 | 389300 | |
| chronic arthritis of rabbits induced by mycoplasmas. i. clinical microbiologic, and histologic features. | mycoplasma arthritidis and mycoplasma pulmonis induced chronic arthritis in rabbits on intraarticular injection, characterized by joint swelling and histologic evidence of chronic active inflammation persisting at least one year. cartilage and bone destruction was a prominent late feature of m arthritidis but not m pulmonis disease. despite the progressive nature of the disease and persistence of active inflammation for many months after inoculation, mycoplasmas and mycoplasma antigens were not ... | 1980 | 6996688 |
| [blast transformation in response to plant mitogens in wistar rats infected with mycoplasma arthritidis or acholeplasma laidlawii]. | the response of lymphocytes of m. arthritidis- or a. laidlawii-infected rats to pha and cona was studied. mycoplasma infection was shown to stimulate the dna synthesis in lymphocytes of the spleen and lymph nodes and to depress the responses to mitogenes one week after infection. by the same time splenocytes of a. laidlawii-infected rats were shown to only slightly proliferate in response to pha. after 4 weeks of infection the lymphocyte transformation was greatly increased in both mycoplasma- a ... | 1980 | 7407377 |
| [stimulation of hematopoiesis in mice inoculated with mycoplasma arthritidis]. | m. arthritidis is known to enhance the leukemogenic effect of rauscher leukemia virus in mice of different strains. as we have found earlier, m. arthritidis enhanced endogenous colony formation in irradiated mice. in this paper we made an attempt to establish a connection between these two phenomena. the mixed inoculation of balb/c mice with m. arthritidis and rauscher leukemia virus produced a great increase in the number of endogenous colonies as compared with the effect of mycoplasmas alone, ... | 1980 | 7415681 |
| [stimulation of erythropoiesis in mice with mycoplasma infections]. | mycoplasma arthritidis was shown earlier to induce erythropoietin-independent erythropoiesis in infected mice. this study demonstrated the increased 59fe incorporation in the mouse spleen as early as day 4 after infection with m. arthritidis. it is known that inoculation of mice with low doses of actinomycin d (act d) results in a specific suppression of erythropoiesis without impairing the endogenous erythropoietin production. in this study the mice were injected with act d (80 microgram/kg bod ... | 1980 | 7448391 |
| [erythropoietin-independent stimulation of erythropoiesis in mice infected with mycoplasma arthritidis]. | it was found previously that m. arthritidis stimulates the endogenous colony formation in sublethally irradiated mice. it was of interest to solve the mechanism of the phenomenon. an attempt was made to show that m. arthritidis promotes the restoration of erythropoiesis in plethoric mice. it is a well known fact that in plethoric mice, the synthesis of endogenous erythropoietin is inhibited as well as the macroscopic erythroid colony formation. it is assumed that early initiation of erythropoies ... | 1980 | 7426724 |
| mycoplasma-dependent activation of normal mouse lymphocytes: requirement for functional t lymphocytes in the cytotoxicity reaction mediated by mycoplasma arthritidis. | syngeneic and allogeneic target cells were killed in the presence of cba mouse lymphocytes and viable mycoplasma arthritidis. medium supplementation had no effect on the response. nonviable m. arthritidis was also capable of stimulating lymphocytotoxicity, although to a much lesser extent. cytotoxicity was shown to be largely dependent upon the lymphocytes, since lymphocytes preincubated with mycoplasmas and treated to remove remaining organisms were highly toxic to target cells, whereas superna ... | 1980 | 6969227 |
| [effect of mycoplasma arthritidis on the hemopoietic cells of mice with a mycoplasma-viral infection]. | 1980 | 7397285 | |
| immunologic reactions of rabbit anti-mycoplasma arthritidis serum with in vitro cultivated rat synovial cells. | the pathogenesis of the intra-articular, arthritic-inflammatory reaction caused by mycoplasma arthritidis in susceptible rats and mice is poorly understood. to investigate this problem, synovial cells from normal sprague-dawley rats were cultured and studied in vitro. these cells continued to produce hyaluronic acid as measured by viscosity and chemical assays. normal synovial cells were treated with rabbit serum specimens taken before and after immunization with m. arthritidis. cytotoxicity ass ... | 1981 | 7250998 |
| stimulation of mouse lymphocytes by a mitogen derived from mycoplasma arthritidis. i. transformation is associated with an h-2-linked gene that maps to the i-e/i-c subregion. | cell-free supernatant derived from broth cultures of mycoplasma arthritidis functions as an effective t cell mitogen for lymphocytes from h2k and h2d strain mice. lymphocytes from animals of the h2b, h2q, and h2s haplotypes failed to respond to this mitogen. by employing lymphocytes derived from congenic and recombinant strains we established the h2 linkage and mapped the controlling gene to the i-e/i-c subregion. in addition, these studies suggested that a correlation existed between responsive ... | 1981 | 7299118 |
| respiration-associated components of mollicutes. | no cytochrome pigments were detected by difference (reduced minus oxidized) spectroscopy at liquid nitrogen temperature in whole-cell preparations or membrane fractions of acholeplasma axanthum s273, acholeplasma equifetale n93, acholeplasma granularum bts39, acholeplasma laidlawii b-pg9, acholeplasma modicum pg-49, acholeplasma oculi 19l, mycoplasma arginini g230, mycoplasma arthritidis 07, mycoplasma pneumoniae fh, and mycoplasma pulmonis jb. all ten mollicutes species examined contained iron ... | 1981 | 7240087 |
| [comparative characteristics of joint changes in rats infected with mycoplasma fermentans and mycoplasma arthritidis]. | experiments on wistar rats have shown that a single injection of m. fermentans or m. arthritidis causes various forms of polyarthritis differing in their course and morphological characteristics. m. arthritidis causes acute purulent arthritis. m. fermentans causes polyarthritis characterized mainly by a subacute course and early involvement of the articular cartilage. plasma cells producing a factor similar to the rheumatoid factor of humans have been detected in the synovial membrane. | 1981 | 7245967 |
| [possible mechanism of the resistance of c57bl/6 mice to a mixed infection with mycoplasma arthritidis and rauscher leukemia virus]. | 1981 | 7231223 | |
| [mycoplasma arthritidis persistence and the cellular immunity indices in experimental arthritis in rats]. | 1981 | 7272371 | |
| acetate kinase activity in mycoplasmas. | acetate kinase activity was assayed in 13 mycoplasmas. nine species exhibited the enzymic activity in the direction of either synthesis of acetylphosphate or adenosine triphosphate. on the other hand mycoplasma orale, mycoplasma arthritidis, ureaplasma urealyticum (10 serotypes), and two strains of anaeroplasma species exhibited only minimal levels of the enzymic activity. in these four species, the enzyme does not seem to play a key role in adenosine triphosphate formation. | 1981 | 6263869 |
| mycoplasma-mediated activation of normal mouse lymphocytes: induction of cytotoxic lymphocytes and lymphocyte transformation by mycoplasma arthritidis are under ir gene control. | the ability of m. arthritidis, a potent arthritogenic agent, to induce normal unsensitized lymphocytes to undergo blast transformation and to become nonspecifically cytotoxic for syngeneic and allogeneic target fibroblasts was found to be dependent upon the donor strain of mouse. lymphocytes from cba (h2k) and balb/c (h2d) mice were identified as high responders and lymphocytes from c56bl/10 mice (h2b) as low or nonresponders. in the cytotoxicity assay the extent of cell lysis was dependent upon ... | 1981 | 6780624 |
| direct activation of the j774.1 murine macrophage cell line by mycoplasma arthritidis. | viable mycoplasma arthritidis and supernatants from m. arthriditis cultures produced marked morphological changes in the j774.1 continuous macrophage line similar to those seen during activation of these cells by mycobacterium bovis bcg cell walls. the mycoplasma-treated macrophages developed pronounced tumoricidal activity against syngenic 3t12-3 target cells and developed an enhanced capacity for the killing of intracellular listeriae, including both virulent and laboratory-maintained strains. ... | 1982 | 6811441 |
| properties of the nucleases of mollicutes. | extracts of the mollicutes acholeplasma equifetale, acholeplasma laidlawii b, mycoplasma arthritidis. mycoplasma pulmonis, and mycoplasma pneumoniae had dnase and endonuclease activity. a. laidlawii b had at least two peaks of dnase activity in sucrose gradients with sedimentation coefficients of 3.1s and 4.3s. these fractions also had endonuclease activity with different substrate specificities. a. laidlawii b may have more than two peaks of endonuclease activity in sucrose gradients. | 1982 | 6811565 |
| stimulation of mouse lymphocytes by a mitogen derived from mycoplasma arthritidis. iii. ir gene control of lymphocyte transformation correlates with binding of the mitogen to specific ia-bearing cells. | the supernatant from mycoplasma arthritidis broth cultures (mas) contains a t cell mitogen that is under ir gene control. responsiveness to this mitogen is dictated by the i-e/i-c subregion of the major histocompatibility complex and is dependent upon adherent radioresistant ia+ accessory cells from responding haplotype animals. in this study, we established that mas could be removed from culture supernatants by absorption with spleen cells from mice that themselves are responsive to the mitogen ... | 1982 | 6125542 |
| mycoplasma arthritidis-induced ocular inflammatory disease. | mycoplasma arthritidis was demonstrated to incite experimental conjunctivitis and uveitis in swiss webster mice which have a known susceptibility to the arthritis customarily associated with infection by this mycoplasma. the initial symptom of ocular involvement was conjunctivitis, which appeared as early as 1 day after intravenous injection with viable culture concentrates of m. arthritidis. by day 2, histological analysis showed intraocular localized inflammatory reactions that were confined p ... | 1982 | 7200961 |
| [immunological characteristics of the membrane and cytoplasmic components of mycoplasma arthritidis]. | 1982 | 7115824 | |
| [long-term persistence of mycoplasma arthritidis in a macrophage culture and the destructive changes effected in the latter]. | 1982 | 7071941 | |
| stimulation of mouse lymphocytes by a mitogen derived from mycoplasma arthritidis. ii. cellular requirements for t cell transformation mediated by a soluble mycoplasma mitogen. | the mitogenic property of supernatants from m. arthritidis cultures (mas) is shown to be nonsedimentable, nondialyzable, labile to 56 degrees c for 1 hr, and active against spleen cells from both normal and germfree mice. both viable m. arthritidis and mas were active for t lymphocytes because anti-thy-1 antiserum and c eliminated responsiveness. spleen cells enriched for t lymphocytes by passage over nylon columns lost responsiveness unless supplemented with a radioresistant adherent cell popul ... | 1982 | 6977580 |
| [effect of mycoplasma arthritidis on the recovery of erythropoiesis in mice treated with 5-fluorouracil]. | m. arthritidis injected into b6af1 hybrid mice 24 hours after 5-fu administration was shown to promote rapid erythropoiesis recovery in the spleen as measured by 59fe incorporation m. arthritidis injected 4 hours after the drug or 4 hours before it was less effective. when inoculated 24 hours before 5-fu, m. arthritidis caused retardation of erythropoiesis recovery. the splenic 59fe incorporation rise in all the cases paralleled the increase in cellularity with an overshoot at day 10-15 after 5- ... | 1982 | 7093487 |
| chronic arthritis of rabbits induced by mycoplasmas. iii. induction with nonviable mycoplasma arthritidis antigens. | preexposure of rabbits to mycoplasma arthritidis predisposed them to subsequent development of chronic inflammation in knee joints challenged with nonviable m arthritidis antigens. rabbits sensitized by hyperimmunization developed a more severe arthritis than those sensitized by infection. unsensitized rabbits responded minimally to intraarticular injection of nonviable organisms. these results suggested that an immune response to a persisting mycoplasmal antigen might be capable of sustaining c ... | 1982 | 7115452 |
| use of arginine aminopeptidase activity in characterization of arginine-utilizing mycoplasmas. | the aminopeptidase activity of arginine-utilizing mycoplasmas was investigated with 20 aminoacyl beta-naphthylamide substrates. high levels of arginyl-beta-naphthylamide hydrolysis were demonstrated in 6 of 11 species when extracts of concentrated washed organisms were used. relatively low arginine aminopeptidase activity was demonstrated with similar extracts from 22 species not utilizing arginine. the high level of arginine aminopeptidase activity could also be demonstrated with unwashed, unco ... | 1982 | 6764773 |
| specificity of a mycoplasma mitogen for lymphocytes from human and various animal hosts. | spleen lymphocytes from lewis and buffalo rats and peripheral blood lymphocytes from 10 human donors exhibited high levels of transformation when exposed to mycoplasma arthritidis supernatants. in contrast, spleen lymphocytes from rabbits and guinea pigs and peripheral blood lymphocytes from sheep and calves failed to transform when exposed to m. arthritidis supernatants. the lymphocytes from all hosts were transformed in the presence of phytohemagglutinin or concanavalin a or both serological s ... | 1982 | 6979514 |
| comparison of the cellular requirements for human t cell transformation by a soluble mitogen derived from mycoplasma arthritidis and concanavalin a. | 1982 | 6980925 | |
| [effect of mycoplasma arthritidis and rauscher leukosis virus on murine peritoneal macrophages in vitro and in vivo]. | the interaction of m. arthritidis and rauscher leukemia virus (rlv) with mouse peritoneal macrophages was studied. when added in vitro, m. arthritidis was shown to exert cytopathic effect on macrophages obtained from normal balb/c or cba mice (highly sensitive to rlv) and baf1 hybrid mice (resistant to rlv) after 4-6 hours of incubation. macrophages obtained from balb/c or baf1 mice infected in vivo with m. arthritidis were functionally defective beginning from day 7. the infection of balb/c mic ... | 1982 | 7080761 |
| [stimulation of the transient endogenous spleen colony formation in normal mice and in plethoric mice infected with mycoplasma arthritidis]. | the number of transient endogenous spleen colonies (tec) formed on days 4-6 postirradiation was found to be greatly increased in mice inoculated with m. arthritidis 1 day prior to sublethal irradiation. in irradiated plethoric mice, tec formation was reduced (about 10-fold), but preinfection with m. arthritidis reversed the effect of plethora, and tec formation in infected plethoric mice was almost as high as in infected normal mice. an abortive wave of 59fe uptake was revealed as early as 5-6 d ... | 1982 | 7150746 |
| h2 gene control and biological activities of a t-cell mitogen derived from mycoplasma arthritidis: a review. | mycoplasma arthritidis generates a soluble, non-dialysable, polyclonal mitogen which is active for murine and human t lymphocytes in the presence of an adherent, radio-resistant, ia-bearing accessory cell population. genetic analysis has established that the i-e sub-region of the murine h2 gene complex controls responses to the mitogen and that this control is exercised at the level of the ia-bearing accessory cell. lymphocyte proliferation, induction of cytotoxic lymphocytes, and interferon ind ... | 1983 | 6433573 |
| studies of polyarthritis caused by mycoplasma arthritidis in rats. iii. histopathological findings. | mycoplasma arthritidis induced polyarthritis in the rat is characterized histologically by four distinct phases. firstly, two days after infection, early lesions such as vascular changes and alterations in the lining cell layer of synovium are observed. this is followed four days after inoculation by an acute exudative phase with the deposit of fibrin and infiltration by polymorphonuclear granulocytes together with first signs of joint destruction by pannus-like granulation tissue. from about th ... | 1983 | 6675351 |
| effect of corynebacterium parvum in the induction and course of mycoplasma arthritis of mice. | the effect of the immunostimulant c. parvum on the establishment and course of mycoplasma arthritis of mice was investigated. male swiss albino mice were injected intra-venously with m. arthritidis culture and intraperitoneally with c. parvum. it was shown that mice immunostimulated with c. parvum were significantly protected against the establishment of arthritis if the mycoplasma was given 9 days after the immunostimulant. however, when the arthritis was established c. parvum had no effect on ... | 1983 | 6678690 |
| [mitogenic action of mycoplasma arthritidis on the lymphoid cells of rats]. | proliferation of rat splenocytes was studied under the conditions of mycoplasma infection in vitro. m. arthritidis in doses less than 10(7) cfu/ml exhibited a mitogenic action which seemed likely to be associated with mycoplasma-produced factor. in higher doses m. arthritidis suppressed blast transformation caused by non-specific mitogens. | 1983 | 6831028 |
| toxicity but not arthritogenicity of mycoplasma arthritidis for mice associates with the haplotype expressed at the major histocompatibility complex. | the use of inbred and congenic mouse strains established that toxicity and death induced by mycoplasma arthritidis associates with the haplotype expressed at the murine major histocompatibility complex. mice bearing h-2k and h-2d are susceptible, whereas those bearing h-2b are much more resistant. mice susceptible to toxicity exhibited massive peritoneal adhesions and a decreased ability to clear organisms from the peripheral circulation. however, the severity of acute arthritis developing over ... | 1983 | 6885154 |
| utilization of t cell hybridomas to establish that a soluble factor derived from mycoplasma arthritidis is truly a genetically restricted polyclonal t cell activator. | 1983 | 6190931 | |
| studies of polyarthritis caused by mycoplasma arthritidis in rats. i. detection of the persisting mycoplasma antigen by the enzyme immune assay (eia) and conventional culture technique. | investigations on mycoplasma (m.) arthritidis polyarthritis of the rat produced by intravenous inoculation of m. arthritidis isr 1 with special reference to the persistence of the inoculated mycoplasma antigen were performed in a total of 145 rats. the mycoplasmas were demonstrated by the conventional culture technique as well as by an enzyme immune assay (eia). m. arthritidis was cultured from liver, kidney, spleen, and thymus up to 4 days, from trachea and uterus up to 4 weeks, and from lung, ... | 1983 | 6232779 |
| induction of human gamma interferons by a mitogen derived form mycoplasma arthritidis and by phytohemagglutinin: differential inhibition with monoclonal anti-hla.dr antibodies. | the peripheral blood lymphocytes from eight healthy volunteers produced significant amounts of interferon (ifn) when co-cultured with a recently discovered mitogen preparation derived from cultures of mycoplasma arthritidis (mas). maximum levels of 281 to 2187 u were reached after 3 to 4 days of incubation. the ifn was characterized as ifn gamma on the basis of ph and heat lability, and neutralization with anti-human ifn gamma but not anti-ifn alpha. a monoclonal antibody to hla.dr determinants ... | 1983 | 6415165 |
| [interaction of acholeplasma laidlawii and mycoplasma arthritidis with the lymphocytes of mice of different strains]. | the interaction of mycoplasmas and mouse lymphocytes has been studied by the microbiological and electron-microscopic methods. the experiments have shown that a. laidlawii and m. arthritidis are adsorbed on lymphocytes and thymocytes of (c57bl6 x a/he)f1, balb and c57bl mice after 15 minutes of their joint incubation at 37 degrees c, 1 hour later adsorption reaches its maximum intensity and after further prolongation of the time of incubation the number of adsorbed microbial cells remains unchan ... | 1983 | 6659765 |
| application of monoclonal antibodies to detect intraocular mycoplasma antigens in mycoplasma arthritidis-infected sprague-dawley rats. | sprague-dawley rats infected with mycoplasma arthritidis by tail vein inoculation develop extensive disseminated joint inflammation, frequently accompanied by conjunctivitis and anterior uveitis. the intraocular inflammation is apparently directed at mycoplasmas localized within the stroma of the ciliary body, which have been detected with monoclonal antibodies by indirect immunofluorescence. the monoclonal antibodies are directed against an antigenic determinant on the enzyme arginine deiminase ... | 1983 | 6339406 |
| studies of polyarthritis caused by mycoplasma arthritidis in rats. ii. serological investigation of rats experimentally infected with m. arthritidis isr 1. | in sera of rats which developed severe polyarthritis after infection with 10(9) cfu of mycoplasma arthritidis isr 1, antibodies against m. arthritidis could be detected by the complement fixation test (cft), enzyme immune assay (eia), indirect hemagglutination (iha), and metabolic inhibition test (mit). peak titers (cft - 1:4096, eia - 1:2560, iha - 1:640 and mit - 1:64) were reached between 2 and 12 weeks after infection. the antibodies persisted for at least 9 months, but started to decrease g ... | 1983 | 6372320 |
| t cell proliferative responses to a mitogen derived from mycoplasma arthritidis are controlled by the accessory cell. | cell-free supernatants from broth cultures of mycoplasma arthritidis (mas) induce vigorous proliferative responses in thymus-derived t lymphocytes from h2k or h2d strains of mice. populations of lymphoid cells from mice of h2b, h2q, or h2s haplotypes do not respond to this stimulus. previous studies with lymphoid cells from congenic and recombinant strains of mice indicate that the t cell proliferative response induced by mas is controlled by a gene(s) that maps to the i-e/c subregion of the mur ... | 1983 | 6413576 |
| induction of interferon gamma in mouse spleen cells by culture supernatants of mycoplasma arthritidis. | factor(s) in the supernatant of cultured mycoplasma arthritidis (mas) represented potent inducers of interferon (ifn) in cultures of mouse spleen cells. responding mouse strains included a/j, balb/c, cba, c3h, and dba/2 whereas spleen cells of c57bl/6 and c57bl/10 mice were nonresponders. interferon production was controlled by the i region of the h-2 locus. treatment of cba spleen cells by anti-thy-1 antibody plus c abolished ifn production. a similar effect was seen when cba spleen cells were ... | 1984 | 6436400 |
| [persistence of mycoplasma arthritidis in the body of mice of different strains]. | mice belonging to 3 strains were shown to differ greatly in their sensitivity to m. arthritidis. this organism persisted for a year in (c57bl/6 x a/sn)f1 mice, for 6 weeks in balb/c mice and for 1-3 weeks in c57bl/6 mice. the sensitivity of mice to m. arthritidis infection and the persistence of the infective agent in the organs of the animals were found to depend on the state of their cell-mediated immunity. | 1984 | 6524169 |
| lymphoproliferation induced in mouse spleen cells by mycoplasma arthritidis mitogen. reversal of the defect of nonresponder mice. | spleen cells of various mouse strains (e.g. balb/c, c311, and cba) reacted towards mas (a mitogen derived from supernatants of cultured mycoplasma arthritidis) with a marked lymphoproliferative response. this reactivity was t-cell-dependent. it was reduced by 90% after removal of macrophages by passage of the spleen cells through sephadex g-10 columns. addition of 2-mercaptoethanol (2-me) to macrophage-depleted cba spleen cells completely restored the response to mas. spleen cells of c57bl/6 and ... | 1984 | 6332372 |
| toxic properties of the mycoplasma arthritidis isr-1 membrane. | isolated membranes of mycoplasma arthritidis isr-1 possess toxic properties for rats, mice and chicken embryos. reactions are dose-dependent. by intravenous injection of 20 mg of membrane protein, a lethal toxicity syndrome resembling shock is induced in sprague-dawley rats of 100 g body weight. mice of approximately 20-g body weight show the same syndrome by intravenous injection of 15 mg of membrane protein. the lethal toxicity for chicken embryos increases from 10 to 80% after injection of 0. ... | 1984 | 6712052 |
| i-e/i-c region-associated induction of murine gamma interferon by a haplotype-restricted polyclonal t-cell mitogen derived from mycoplasma arthritidis. | cell-free supernatants from cultures of mycoplasma arthritidis induced significant levels of interferon when cocultured with murine splenic cells. on the basis of physicochemical characteristics and antibody neutralization studies, the antiviral substance was identified as gamma interferon. use of inbred and congenic mouse strains established that splenic cells from mice expressing the h2k and h2d haplotypes produced interferon in response to m. arthritidis culture supernatants, but those from m ... | 1984 | 6418659 |
| antigenic cross-reactions between mycoplasma arthritidis and rat tissues. | an antigenic relationship between mycoplasma arthritidis and rat tissues could be demonstrated using the enzyme-immune assay and the agar gel double diffusion test. cross-reactions were observed with joint homogenates as well as with muscle, lung, liver, kidney, spleen and brain tissue from rats. in addition, antibodies against joint homogenate were found in the sera of rats infected with m. arthritidis isr 1 using the indirect hemagglutination test. the significance of common antigens between m ... | 1984 | 6206639 |
| unusual reactivity of lymphocytes from patients with ankylosing spondylitis to mitogen derived from mycoplasma arthritidis. | 1984 | 6208448 | |
| lymphoproliferative responses of spleen cells of inbred rat strains to mycoplasma arthritidis mitogen. | a potent mitogen for t lymphocytes of various species has recently been isolated from the supernatant of cultured mycoplasma arthritidis organisms (mas). in the mouse, reactivity to this mitogen has been observed to be controlled by the i-e subregion of the major histocompatibility complex. we have analysed the responses of spleen cells from several inbred rat strains covering practically all known haplotypes of the major histocompatibility complex of the rat (rt1). unlike in the mouse, all of t ... | 1984 | 6209789 |