Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| influence of protein and calorie deficiencies in the rat on the energy-transfer reactions of the striated muscle. | 1964 | 4284462 | |
| [effect of epiphysectomy on the ovary of the golden hamster (mesocricetus auratus waterh.)]. | 1967 | 4231631 | |
| action of cloxacillin and nafcillin on escherichia coli. | 1968 | 4868481 | |
| [state of current physiologic research. significance of na+ for the transport of sugars by the epithelial membranes]. | 1968 | 4874684 | |
| activation of adenyl cyclase by glucagon in cat and human heart. | 1969 | 4303624 | |
| activation of adenyl cyclase by glucagon in cat and human heart. | 1969 | 4303624 | |
| anti-amphetamine activity of fenfluramine and s 992 in the isolated tail artery of the rat. | 1969 | 4390838 | |
| anti-amphetamine activity of fenfluramine and s 992 in the isolated tail artery of the rat. | 1969 | 4390838 | |
| concerning the histamine receptor (h1). | 1969 | 4390839 | |
| an unusual inhibitory effect of histamine: suppression of atropine-resistant tetanic spasms after mepyramine block of histamine contractions. | 1969 | 4390876 | |
| effect of cooling on beta-receptor mechanisms in isolated saphenous veins of the dog. | 1970 | 4394263 | |
| [studies of the part played by angiotensin in the transport and metabolism of isonicotinic acid hydrazine (inh)]. | 1970 | 4321539 | |
| [studies of the part played by angiotensin in the transport and metabolism of isonicotinic acid hydrazine (inh)]. | 1970 | 4321539 | |
| [outline on the current studies on healing process in tooth extraction wounds]. | 1970 | 4991836 | |
| independence of allotypic determinants and antibody specificity. | 1970 | 4195497 | |
| preparation of hepatic microsomal fraction for drug metabolism studies by rapid decompression homogenization. | 1972 | 5041006 | |
| cultural characteristics of a cell line derived from an equine sarcoid. | a cell line, derived from a spontaneous equine connective tissue tumor (equine sarcoid), has been established. the morphological and growth characteristics indicative of malignant transformation of the cells include a disoriented, rapid growth and loss of contact inhibition. further evidence of transformation is the agglutination of these cells by concanavalin a and their ability to divide in semisolid media. | 1972 | 4640736 |
| [susceptibility of culex pipiens molestus, forskal mosquitoes of the moscow population to wuchereria bancrofti, cobbold]. | 1972 | 4653706 | |
| reflex pathways controlling lactation. | 1972 | 4569722 | |
| occurrence of protein a in various serologic types of staphylococci. | 1972 | 4260171 | |
| cooperative interactions in enzymes: the binding of 1, n6-etheno-atp to aztobacter vinelandii nitrogenase. | 1973 | 4133565 | |
| [slow viruses and the central nervous system. i]. | 1973 | 4579465 | |
| proceedings: role of cytotoxic antibodies and immune complexes in rats bearing enhanced renal allografts. | 1974 | 4598983 | |
| [antibiotics in food products (review of the literature)]. | 1974 | 4611007 | |
| proceedings: uptake of neurotransmitters into subcellular particles of the caudate nucleus. | 1974 | 4152365 | |
| protein kinases in testes of adult and prepuberal rats. | 1974 | 4369082 | |
| survey of helminth infections in maine dairy cattle. | the survey was done to determine the incidence and seasonal prevalence of the gastrointestinal helminths infecting maine dairy cattle. approximately equal groups of calves, heifers, and cows from 13 dairy farms, managerially and geographically representative of dairying in the state, were sampled at regular 2-month intervals over the period of a year. on the basis of fecal egg counts and identification of cultured larvae, the following results were obtained: of the 94 adult cows, 78 heifers, and ... | 1975 | 127538 |
| transcription of simian virus 40 dna by escherichia coli rna polymerase: synthesis of a dna-rna hybrid and discrete rnas under restrictive transcription conditions. | 1975 | 167179 | |
| femoral percutaneous catheterization in infants and small children for cerebral angiography. | an improved technique of selective cerebral angiography for infants and small chicken is described. the needle is inserted approximately 45 degrees to the skin in order to avoid subintimal placement of the tip. after good backflow is established, the guidewire is advanced to a position in the descending aorta. a no. 3 polyethylene catheter and 21-gauge scalp vein needle were most successful. | 1975 | 1153751 |
| [repeated obtaining of dog peritoneal macrophages and their cultivation in vitro]. | 1975 | 1214674 | |
| human placental lactogen concentration during physiological fluctuations of serum glucose in normal pregnant and gestational diabetic women. | oral glucose tolerance tests (ogtt) were carried out in 9 normal pregnant women and 11 non-obese gestational diabetics in late pregnancy. all samples were analysed for the content of glucose, insulin and placental lactogen hormone (hpl). furthermore, spontaneous changes in the serum hpl concentration during a 3 h period were studied in 6 normal women in the 2nd half of pregnancy. during ogtt only small and insignificant changes in the level of hpl were observed in both the normal subjects and th ... | 1975 | 1242271 |
| attenuated, streptomycin-dependent salmonella typhi oral vaccine: potential deleterious effects of lyophilization. | four studies were done with streptomycin-dependent salmonella typhi as an oral, attenuated vaccine. studies 1 and 3 employed freshly harvested vaccine, whereas studies 2 and 4 involved lyophilized vaccine. five to eight doses (3 x 10(10)-10(11) organisms/dose) were given; oral streptomycin (1.0 g) was administered concomitantly in studies 2 and 3, with only two of the doses of vaccine in study 1, and was not given in study 4. no adverse reactions were encountered in 179 vaccinated men, and 94% o ... | 1976 | 1262709 |
| the selective suppression of an antibody response to a given antigen. | 1976 | 1084334 | |
| alteration of colony-stimulating factor output, endotoxemia, and granulopoiesis in cyclic neutropenia. | cellular and humoral factors involved in the regulation of granulopoiesis were evaluated in two patients with cyclic neutropenia by utilizing the agar-gel marrow culture technique to serially study marrow granulocytic colony-forming capacity (cfc) and the urinary output of colony-stimulating factor (csf). csf output varied inversely with peripheral neutrophil counts and directly with monocyte counts and evidence for infection (endotoxemia and/or staphylococcal abscesses). following autologous in ... | 1976 | 1087533 |
| a linkage study of rabbit serum high density lipoprotein (hdl) allotypes. | close linkage between the two allotypic systems of rabbit serum high density lipoprotein (hdl), hl 1 and r 67, has been confidently excluded, the recombination fraction being at least 0-20. no suggestion of linkage between either hdl allotype and the immunoglobulin allotypes a1a2a3/b4b9, or the red blood cell system (rbc) adf was obtained. close linkage was confidently excluded for the hl 1-adf, hl 1-a1a2a3, r 67-adf, r 67-a1a2a3, r 67-b4b9, a1a2a3-b4b9, and b4b9-adf relationships. | 1977 | 194985 |
| comparison of interferon action in interferon resistant and sensitive l1210 cells. | translation inhibition, leu-trna aminoacylation and double-stranded rna and atp dependent phosphorylation were examined in interferon-treated and control cell-free lysates of leukaemic mouse l 1210 r and l 1210 s cells. no differences were observed between the respective interferon-treated and control cell-free extracts, except for the presence of an enhanced 67k dalton phosphoprotein fraction in interferon-treated l 1210 s cell-free extracts. in non-responding cell-free lysates, the lack of sti ... | 1978 | 212514 |
| mucin-producing atypical bronchial carcinoid. | in a case of atypical mucin-producing bronchial carcinoid in a 40-year-old man covert metastases were present at the time of lobectomy and were revealed at necropsy--a feature highlighting the malignant potential of the atypical carcinoid. | 1978 | 219040 |
| hypothalamic-pituitary responses to intracranial self-stimulation in the rat. | the effects on pituitary and adrenal hormones of intracranial self-stimulation (iss) and forced stimulation in rewarding (ps) and non-rewarding (nss) sites were investigated in adult male rats. growth hormone (gh) was suppressed during periods of iss and ps and rose sharply to a peak within 15 min of cessation. the interval between gh secretory episodes was significantly shortened during all 3 types of stimulation when compared to the normal rhythmic discharge observed in freely behaving baselin ... | 1978 | 308836 |
| eosinophil chemotactic factor (ecf). iii. generation in human peripheral leukocytes. | eosinophil chemotactic factor (ecf) can be released from human peripheral leukocytes by an ige-anti-ige reaction, by the calcium ionophore a 23187 and during phagocytosis. supernatants and sonicates of unstimulated cells contain little or no ecf. on stimulation, however, ecf activity increases in the cells and even more so in the supernatants. this holds for purified neutrophils (pmns) as well as for basophil-containing mononuclear cell preparations. these findings contrast with those in lung ho ... | 1978 | 344230 |
| [laboratory experiments with a polyvalent extract vaccine for oral immunization against e. coli enteritis]. | bacteria of e. coli causing enteritis can be extracted by edta-sodium. these extracts having lower dry weights result in better protective effects in contrast to sodium-deoxycholate extracts. the edta-sodium extracts can be concentrated, purified and sterile filtrated. thus the production of polyvalent vaccines is possible. a direct relation exists between the effectiveness of the extracts and the virulence of the strains used for extraction. the more virulent the original strain the better is t ... | 1978 | 373349 |
| [autoradiographic studies on the distribution of 14c-piracetam in the simian brain]. | autoradiography of the brain of the monkey callithrix jacchus 2 and 6 h after oral application of 200 mg 14c-piracetam/kg (2-oxo-pyrrolidine-l-acetamide-2-14c) shows that the drug is preferably concentrated in the cortex of cerebrum and cerebellum. this specific affinity of piracetam which was observed earlier in dog and rat is thus confirmed in the primate and seems to be species independent. beside the dominant cortical concentration there is a characteristic storage of piracetam in many nucle ... | 1978 | 415743 |
| [the effect of substance p on smooth musculature of the gastrointestinal tract (proceedings)]. | 1979 | 515151 | |
| [contributions of thoracic surgery in the research institute for pulmonary diseases and tuberculosis since its founding and under the presence conditions in the treatment of specific and nonspecific lung diseases (author's transl)]. | thoracic surgery is done in the research institute for pulmonary diseases and tuberculosis for about 25 years. 2463 lung resections on account of tuberculosis, 934 lung resections on account of intrathoracic tumors, among them 795 suffering from bronchial carcinoma, 422 operations because of nonspecific pulmonary diseases (bronchiectasis, lung abscess a.s.o.) and nearly the same number of operations because of spontaneous pneumothorax were performed in this time. cystic lung disease, bullous emp ... | 1979 | 516807 |
| dna methylation: organ specific variations in the methylation pattern within and around ovalbumin and other chicken genes. | the restriction enzymes hhai and hpaii, whose activity is inhibited by cytosine methylation within their recognition sites, have been utilised as probes to study methylation in the vicinity of the ovalbumin gene in dna from various chicken tissues. this was complemented by a preliminary study of methylation in the regions of chicken ovotransferrin (conalbumin), ovomucoid and beta-globin genes. from our data we conclude that hai or hpaii sites can be divided in 3 classes according to their patter ... | 1979 | 523314 |
| plasma hemoglobin in rectal or intravenous hydrogen peroxide for extrapulmonary oxygenation. | 1979 | 524918 | |
| alteration of tissue zinc distribution and biochemical analysis of serum following pinealectomy in the rat. | eight weeks following pinealectomy in adult male wistar rats, zinc levels of various tissues were found to be significantly altered: zinc in thoracic aorta was significantly increased, and in serum, pituitary, adrenal, heart, lung, and body hair, it was decreased. serum biochemical analysis indicated that there was a significant elevation of cholesterol, alkaline phosphatase, sodium, urea, and creatinine in serum from pinealectomised rats. liver, spleen, and thymus weights were lower following p ... | 1979 | 544273 |
| suppressor of deoxythmidine monophosphate uptake in saccharomyces cerevisiae. | although yeast cannot normally incorporate exogenous deoxythymidine 5'-monophosphate (dtmp) into deoxyribonucleic acid, mutants able to do so have been isolated. we have characterized a recessive suppressor of dtmp uptake (sot1) that prevents strains carrying either tup1, tup2, or tup4 from growing on selective medium. the sot1 mutation maps between rad1 and the centromere of chromosome xvi, and is unlinked to any of the tup mutations. the sot1 mutation does not suppress the other pleiotropic ef ... | 1979 | 374400 |
| antibodies against the light chain of tetanus toxin in human sera. | tetanus toxoid elicits protective antibodies against tetanus toxin in humans and animals. it has been reported that antitoxin from immunized humans contains no anti-light chain antibodies, based on immunodiffusion and quantitative precipitin analyses. we confirmed the absence of precipitating anti-light chain antibodies in tetanus immune globulin. however, the presence of antibodies against the light chain of the toxin was shown by direct binding and inhibition analyses, using enzyme-linked immu ... | 1985 | 2409006 |
| spatial patterns produced by a reaction-diffusion system in primary hair follicles. | this paper is the third in a series examining the role of a reaction-diffusion (rd) system as the principal mechanism providing spatial information for cell differentiation during hair follicle initiation and development and hair fibre formation. a theoretical mechanism is described by which the rd system supplies positional information during hair follicle development. solutions of the rd system within the primordial follicle are described as well as the sequence of spatial patterns provides th ... | 1985 | 2412073 |
| dose-dependent effect of calcium and magnesium etidronate on salicylic acid absorption in the rat. | disodium etidronate affected salicylic acid absorption from the rat small intestine, in-situ, when instilled into a jejunal segment for different exposure times before the salicylic acid absorption was measured. at low etidronate concentrations and short exposure times, the salicylic acid absorption rate was significantly increased compared with saline controls. at high etidronate concentrations and longer exposure times, the absorption rate was reduced. etidronate precomplexed with calcium or m ... | 1985 | 2862271 |
| contextual influences on conditioned taste aversions in the developing rat. | 1985 | 3860078 | |
| osteocalcin in human serum: a circadian rhythm. | osteocalcin, the vitamin k-dependent protein synthesized in bone, is found in blood. the level of circulating osteocalcin has recently been used as an indicator of the rate of bone turnover. we measured serum osteocalcin during 24-h periods in 6 normal 20- to 30-yr-old men and 4 women. blood was sampled via an indwelling venous catheter every 30 or 60 min for 24 h. circadian rhythmicity in circulating osteocalcin was found in 9 of the 10 individuals studied. osteocalcin levels fell during the mo ... | 1985 | 3871789 |
| yeast sterols: yeast mutants as tools for the study of sterol metabolism. | yeast mutants defective in ergosterol synthesis are valuable tools for investigating sterol metabolism. both sterol mutants and sterol auxotrophs have been utilized in determining what sterol structural features are required for yeast cell viability. both types of mutants can also be studied to ascertain how changes in sterol structure affect membrane properties. other aspects of sterol metabolism, such as the specificity of sterol esterification, have been elucidated by the sterol auxotrophs. i ... | 1985 | 3897776 |
| [nutrient medium for the isolation and cultivation of pneumococcus]. | a culture medium for the isolation and cultivation of pneumococci, produced in a solid or liquid form and based on raw material unsuitable for use as foodstuff (human placenta), has been developed. the amino acid composition of the medium has been studied. the medium has been found to contain 19 amino acids, to be free from ballast serum proteins and blood, and to ensure the good growth of pneumococci isolated from pathological material, the formation of the normal capsule, as well as active bio ... | 1985 | 4060949 |
| evoked olfactory responses in neonatal rats. | although there is behavioral evidence that rat pups respond to odors, the physiological basis of the response is unclear. in the present study, eight different odors were presented to 44 anesthetized rat pups between the ages of 0 and 20 days, and recordings of electrical activity were made from the olfactory bulb. the major finding was that, contrary to earlier neurophysiological findings, even on the first day of life--when spontaneous electrical activity is minimal--evoked potentials, in the ... | 1985 | 4094844 |
| 6-mercaptopurine: total body autoradiograms and plasma concentration-time curves of 6mp and metabolites from marmoset monkeys. | to study the body distribution of 6-mercaptopurine (6mp), [8-14c]6mp was given by infusion to 2 marmoset monkeys at a dose rate of 5 mg/kg body weight/h for 1 and 4 h, respectively. both experimental animals were sacrificed 2 h after the end of the drug infusion and instantly frozen at -70 degrees c. whole-body sagittal sections were made later. blood samples were obtained regularly during the experiments to quantitate 6mp, 6mp riboside (6mpr), 6-thioxanthine, and 6-thiouric acid in plasma. the ... | 1986 | 3153226 |
| [seasonal changes in the count of mites of the family pyroglyphidae in houses in the city of cheboksary]. | the results of human dwelling houses surveying for the presence of home dust mites and study of seasonal changes of their quantity in the town of cheboksary are given. it has been found that the old wooden houses are inhabited by mites, in modern blocks of flats they are met rather seldom. the quantity of alive mites is maximum in september-october. the common number of mites is the greatest in december-january although the quantity of alive mites at this time is only 6.8%. | 1986 | 2939887 |
| chronopharmacological study of furosemide in rats. | the present experiment was undertaken to determine whether or not the effects of furosemide depend upon the administration time and, if so, to study the mechanism(s) for these variations. after administration of furosemide (5 mg/kg) in wistar rats at 10:00 or at 22:00, urine volume and urinary excretion of sodium, furosemide, and prostaglandin e2 (pge2) were measured. urine volume and urinary excretion of sodium and furosemide, but not pge2, were significantly greater when furosemide was adminis ... | 1986 | 3457231 |
| peripheral blood natural killer cell activity in human breast cancer patients and its modulation by t-cell growth factor and autologous plasma. | the role of clinical status and chemotherapeutic intervention on native and inducible natural killer cell (nk) activity in breast cancer was ascertained by determining the k562 cytotoxicity capacity of peripheral blood lymphocytes. the level of nk activity in breast cancer patients receiving chemotherapy (n = 62) was significantly lower than that observed in patients currently receiving no treatment (n = 56) (at effector: target [e:t] ratios of 20:1, 10:1, and 5:1, 23.8%, 17.9%, and 12.1% versus ... | 1986 | 3487379 |
| analysis of the internal nuclear matrix. oligomers of a 38 kd nucleolar polypeptide stabilized by disulfide bonds. | when rat liver nuclei are treated with the sulfhydryl cross-linking reagent sodium tetrathionate (natt) prior to nuclease treatment and extraction with 1.6 m nacl, residual nucleoli and an extensive non-chromatin intranuclear network remain associated with the nuclear envelope. subsequent treatment of this structure with 1 m nacl containing 20 mm dithiothreitol (dtt) solubilizes the intranuclear material, while the nuclear envelope remains structurally intact. we have isolated and partially char ... | 1986 | 3514251 |
| high oxygen requirements of dyskinetic cardiac muscle. | this study assesses the regional oxygen requirements of muscle segments that are beating and working, beating and empty, arrested and decompressed, and nonischemic that move dyskinetically. regional oxygen demands were evaluated by producing a dyskinetic segment by infusing regional cardioplegic solution through a left anterior descending coronary artery catheter with and without extracorporeal circulation. the results show that the o2 demands of the perfused dyskinetic cardiac muscle segment (4 ... | 1986 | 3747582 |
| in vitro acetylcholine synthesis and oxidative metabolism during development of normal and brindled mouse brain. | during early development normal and brindled mouse brain use 3-hydroxy-butyrate preferentially to glucose as a source for biosynthetic carbon units. on postnatal days 5-60, co2 and acetylcholine production from 3-hydroxybutyrate decrease while that from glucose increases. glucose metabolism exceeds that of 3-hydroxybutyrate after weaning (day 21). these findings indicate that the immature brain uses 3-hydroxybutyrate to support effectively oxidative metabolism and acetylcholine synthesis. defici ... | 1986 | 3768723 |
| the effect of altered hormonal states on some enzymes of gluconeogenesis in the genital organs of immature female rhesus monkeys. | 1986 | 3779756 | |
| beta-adrenoceptor-mediated modulation of calcium ionophore activated polymorphonuclear leucocytes. | beta-adrenoceptor-mediated modulation of calcium-mediated stimulus-response coupling was studied using calcium ionophore (a23187) activation of polymorphonuclear leucocytes (pmnl). oxygen metabolite generation was measured with luminol- and lucigenin-dependent chemiluminescence in both whole blood and isolated pmnl. isoprenaline reduced pmnl response by 53% in a dose-dependent fashion. the effect was saturable, stereoselective, antagonized by propranolol and significant at isoprenaline concentra ... | 1986 | 2873859 |
| beta-adrenoceptor-mediated modulation of calcium ionophore activated polymorphonuclear leucocytes. | beta-adrenoceptor-mediated modulation of calcium-mediated stimulus-response coupling was studied using calcium ionophore (a23187) activation of polymorphonuclear leucocytes (pmnl). oxygen metabolite generation was measured with luminol- and lucigenin-dependent chemiluminescence in both whole blood and isolated pmnl. isoprenaline reduced pmnl response by 53% in a dose-dependent fashion. the effect was saturable, stereoselective, antagonized by propranolol and significant at isoprenaline concentra ... | 1986 | 2873859 |
| enzymes of catecholamine metabolism in the brains of rat strains differing in their preference for or tolerance of ethanol. | the activities of the catecholamine-synthesizing and inactivating enzymes were determined in whole brains of two pairs of rat strains differing in their genetically-determined behavioural responses to ethanol. the alcohol-tolerant (at) rats did not show any significant differences in enzyme activities when compared with the non-tolerant (ant) strain. the activity of tyrosine hydroxylase was found to be significantly higher in brains of the alcohol-preferring (aa) rats, than in those of the alcoh ... | 1986 | 2874817 |
| a dot immunobinding assay (dia) on nitrocellulose membrane for the serological detection of antibodies to entamoeba histolytica. | a rapid, cheap, simple and specific serological test of adequate sensitivity for detecting igg antibodies against entamoeba histolytica antigen is described. axenically cultured amoebic antigen was used to precoat the nitrocellulose membrane. the strips were incubated with test samples and later with horseradish peroxidase (hrpo) labelled protein-a conjugate. a dark blue spot was obtained by treatment with peroxidase substrate, 4-chloro-1-naphthol, in positive samples. serum samples from 32 heal ... | 1986 | 2885949 |
| a monoclonal antibody raised to corpus callosum extract reacts with 2',3'-cyclic nucleotide 3'-phosphohydrolase. | monoclonal antibody against 2',3'-cyclic nucleotide 3'-phosphohydrolase (cnp) was generated by fusing mouse myeloma cells with spleen cells from balb/c mice immunized with delipidated white matter from rat corpus callosum. the antibody was characterized by solid-phase radioimmunoassay, immunoblot of sodium dodecyl sulfate-polyacrylamide gel electrophoresis (sds-page), immunoprecipitation from c6 glioma cells, and indirect immunofluorescence staining of monolayer cultures containing oligodendrocy ... | 1986 | 2999339 |
| increased sensitivity of fat cell adenylate cyclase to stimulatory agonists during fasting is not related to impaired inhibitory coupling system. | in rat adipocytes, inhibition of the forskolin-stimulated cyclic amp response by nicotinic acid and n6-phenylisopropyladenosine was unaltered by a 72 h fasting. under assay conditions favouring inhibition, basal and forskolin-stimulated adenylate cyclase responses to inhibition by gtp and nicotinic acid were also unimpaired by fasting. under the same conditions, however, low gtp concentrations elicited a clear activatory effect in membranes from fasted but not from fed rats. fasting failed to al ... | 1986 | 3013688 |
| increased sensitivity of fat cell adenylate cyclase to stimulatory agonists during fasting is not related to impaired inhibitory coupling system. | in rat adipocytes, inhibition of the forskolin-stimulated cyclic amp response by nicotinic acid and n6-phenylisopropyladenosine was unaltered by a 72 h fasting. under assay conditions favouring inhibition, basal and forskolin-stimulated adenylate cyclase responses to inhibition by gtp and nicotinic acid were also unimpaired by fasting. under the same conditions, however, low gtp concentrations elicited a clear activatory effect in membranes from fasted but not from fed rats. fasting failed to al ... | 1986 | 3013688 |
| the ability of single sex infections of schistosoma japonicum to induce resistance to reinfection in mice. | in four experiments, mice harbouring an average 50, 76 or over 200 schistosoma japonicum female worms were not resistant when challenged six to eight weeks after infection. the female worms from these single sex infections were stunted and immature (average length 4.6 mm) and induced no overt pathology in the host. male worm burdens of 60, 135 or 140 also induced little or no resistance to challenge in the host. the males from these single sex infections were fully grown for their age (average l ... | 1986 | 3091678 |
| nascent high density lipoproteins from liver perfusates of orotic acid-fed rats. | uniformly fatty livers from orotic acid-fed rats secreted almost no very low density lipoproteins (vldl) but normal amounts of nascent high density lipoproteins (hdl) accumulated in perfusates. when lecithin:cholesterol acyltransferase (lcat) was inhibited, nascent hdl were uniformly discoidal and lacked cholesteryl esters. lipid and apoprotein compositions of nascent hdl from normal and fatty livers were similar whether lcat was inhibited or not. apolipoprotein b-100 was not detected in perfusa ... | 1986 | 3097228 |
| ampicillin resistant gonorrhoea in hong kong. | 1986 | 3102346 | |
| calcium-promoted translocation of protein kinase c to synaptic membranes: relation to the phosphorylation of an endogenous substrate (protein f1) involved in synaptic plasticity. | the translocation of protein kinase c between membrane and cytosol has been implicated in several cellular processes (kraft and anderson, 1983; wooten and wrenn, 1984; akers et al., 1985, 1986; hirota et al., 1985; wolf et al., 1986). we desired to identify potential trigger mechanisms underlying the translocation of protein kinase c activity to neural membranes following the synaptic plasticity observed after long-term potentiation (ltp; akers et al., 1986). takai et al. (1979) have suggested a ... | 1987 | 3121805 |
| calmodulin-mediated cadmium inhibition of phosphodiesterase activity, in vitro. | ion-stripped bovine brain calmodulin (cam) binds 4 moles cd2+ as well as 4 moles ca2+ per mole protein, with similar affinity; in the presence of 1 mm mg2+ the molar binding ratio of cam for ca2+ decreased to 3, the apparent k0.5 for ca2+ nearly doubled, but the binding characteristics of cam for cd2+ were not changed. saturating concentrations ca2+ did not affect the molar binding ratio of cam for cd2+, but increased the apparent k0.5 for cd2+; vice versa, saturating concentrations cd2+ decreas ... | 1987 | 3034196 |
| redifferentiation and subsequent dedifferentiation of the livers of roosters resulting from acute estrogen challenges. | 1. histologic and metabolic changes take place in livers of rooster receiving challenges consisting of acute doses of estrone. 2. during initial growth and redifferentiation livers rapidly increase in size by division of hepatocytes within most lobules, changing from cordlike to acinar configurations. 3. no new lobules appear and degeneration of some cells within lobules takes place even as cell divisions predominate. 4. cells within lobules assume secretory features. 5. vitellogenins, very low ... | 1987 | 2887384 |
| a new glucocorticoid receptor detected in host rat liver but not in various hepatomas. | previously a new glucocorticoid receptor (peak c), which eluted with 0.12 to 0.14 m nacl from deae-cellulose column, was identified in addition to another receptor (peak b), a classic type of glucocorticoid receptor, which eluted with 0.05 to 0.08 m nacl. peak c appeared after stress or injection of a high dose (20 micrograms/100 g body weight) of dexamethasone into rats. peak c was also detected in the liver of rats bearing various tumors, but it was not found in malignant tumors (yoshida sarco ... | 1987 | 2885083 |
| relationship of myocardial metabolism and coronary flow: dependence on extracellular calcium. | the hypothesis that extracellular [ca2+] ([ca2+]e) influences the transmission of vasoregulatory information from the heart to coronary smooth muscle was examined. the isolated, retrogradely perfused rat heart was used to evaluate vascular reactivity to transient infusion of either 0.88 mm amytal (amobarbital), hypoxia (95% n2-5% co2), or 12 microm adenosine in the presence and absence of 2.5 microm verapamil. amytal alone enhanced coronary flow by 78% and lactate efflux by 10-fold, whereas it d ... | 1987 | 2446512 |
| onset of steroidogenesis and differentiation of functional lh receptors in rat fetal testicular cultures. | the present study was performed to investigate in vitro the onset of steroidogenesis and the responsiveness to lh in rat fetal testes. the male gonads explanted on days 12.5, 13.5, and 14.5 of gestation in m199 produced testosterone from 15.5 days as is the case in vivo dcamp (1 mm) induced an anticipated steroidogenesis on day 14.5 with secretions of testosterone (0.026 +/- 0.003 ng/gonad/24 h) and progesterone (0.078 +/- 0.005 ng/gonad/24 h), whereas lh (100 ng/ml) has no effect. antiandrogens ... | 1987 | 2823733 |
| light-induced charge separation in photosystem i at low temperature is not influenced by vitamin k-1. | the photoreduction of iron-sulfur centers was studied at low temperature in photosystem i particles from spinach and the cyanobacterium synechocystis 6803, which contain various amounts of vitamin k-1 (recently tentatively identified as the acceptor a1). the irreversible charge separation that was progressively induced at low temperature between p-700 and fa (or fb) by successive laser flashes was studied at 15 k. its maximum amount after a large number of flashes was shown to be fairly independ ... | 1987 | 2823891 |
| involvement of the membrane skeleton in the regulation of the camp-independent protein kinase and a protein phosphatase that control protein synthesis. | 1987 | 2832271 | |
| coronary hemodynamics and myocardial metabolism of lactate, free fatty acids, glucose, and ketones in patients with septic shock. | to investigate disturbances in the coronary circulation and myocardial metabolism during septic shock, we examined coronary sinus blood flow and myocardial substrate extraction in 40 patients with septic shock and 13 control patients. patients with coronary artery disease were excluded from this study. the global hemodynamic pattern of the septic patients was characterized by a lower stroke volume, despite an elevated cardiac index. coronary sinus blood flow was high (187 +/- 47 vs 130 +/- 21 ml ... | 1987 | 3815765 |
| effect of altrenogest and lutalyse on parturition control, plasma progesterone, unconjugated estrogen and 13,14-dihydro-15-keto-prostaglandin f2 alpha in sows. | to investigate control of parturition time, 154 sows farrowing 220 litters at three locations were treated with altrenogest and lutalyse (pg). the four treatment groups were: 1) no treatment (control group); 2) an im injection of 15 mg of pg at 1000 on d 111, 112 or 113 of gestation (d 0 = first day of estrus and gestation); 3) altrenogest (20 mg x sow-1 x d-1) fed twice daily for 4 d starting on d 109, 110 or 111; and 4) altrenogest and an injection of pg at 1000 on the day after the last feedi ... | 1987 | 3610870 |
| [data providing a basis for the mac of the cleaning agent "blesk-3" in work zone air]. | 1987 | 3623181 | |
| a scanning electron microscope study on the autonomic groundplexus in the lamina propria mucosae of the guinea-pig small intestine. | the occurrence and fine structure of the autonomic groundplexus in the lamina propria mucosae of the guinea-pig small intestine were studied by scanning electron microscopy after removing connective tissue elements by maceration in hydrochloric acid. transmission electron microscopy was also performed to investigate the fine structure of the neuronal and glial elements in the autonomic groundplexus. nerve fasciculi consisting of neuronal processes and enteroglial cell sheaths formed a three-dime ... | 1987 | 3662754 |
| covalent binding of an nad+ analogue to horse liver alcohol dehydrogenase in a ternary complex with pyrazole. | examination of the model of the fixation site of the adenosine phosphate part of nad+ on horse liver alcohol dehydrogenase led us to synthesize a nad+ analogue n6-[n-(8-amino-3,6-dioxaoctyl)carbamoylmethyl]-nad+ in order to alkylate the carboxylic acid group of asp-273 and to convert the normally dissociable coenzyme into a permanently bound prosthetic group. this nad+ analogue is coupled to the horse liver alcohol dehydrogenase in the ternary complex formed with pyrazole. in these conditions th ... | 1987 | 3665930 |
| distribution of immunoreactive inhibin like material in different regions of human prostate. | distribution of immunoreactive inhibin material (ir-ilm) in different regions of human prostate was studied by using specific radio-immunoassay. mean ir-ilm concentrations in the central, peripheral and periurethral zones were 27.3 +/- 9.3, 2.4 +/- 0.7 and 3.0 +/- 1.5 micrograms/mg protein respectively (p central vs periurethral and peripheral less than 0.05). | 1987 | 3688474 |
| separation of the genetic loci for the h-y antigen and for testis determination on human y chromosome. | the mammalian y chromosome encodes a testis-determining factor (termed tdf in the human), a master regulator of sex differentiation. embryos with a y chromosome develop testes and become males whereas embryos lacking a y chromosome develop ovaries and become females. expression of h-y, a minor histocompatibility antigen, may also be controlled by a gene on the y chromosome, and it has been proposed that this antigen is the testis-determining factor. we have tested the postulated identity of h-y ... | 1987 | 3494951 |
| human milk-derived lactoferrin inhibits mitogen and alloantigen induced human lymphocyte proliferation. | purified lactoferrin (lf), isolated from human milk, was tested for its effect on human t-lymphocyte proliferative responses to phytohemagglutinin (pha) and to alloantigens in mixed lymphocyte culture. lf inhibited proliferation in both assays in a dose-dependent manner. the suppressive effect was not due to lf mediated cytotoxicity since washing cells that had been pre-incubated with lf restored their proliferative activity. lf was most effective in suppressing the pha response when added withi ... | 1987 | 2963123 |
| variations in number and functional capacity of blood mononuclear cells during the peripartal period in the gilt. | 1988 | 3195260 | |
| clinical parameters of donkeys before and after trypanosoma vivax infection. | 1988 | 3201022 | |
| the human pattern of gyrification in the cerebral cortex. | the degree of cortical folding found in adult human brains has been analyzed using a gyrification index (gi). this parameter permits the description of a mean value for the whole brain, but also a local specific analysis of different brain regions. correlation analyses of the gi with age, body weight, body length, brain weight and volume of the prosencephalon and the cortex show no significant results. gi values do not differ significantly between male and female brains, right and left hemispher ... | 1988 | 3232854 |
| prophylactic parenteral antibiotics in clean neurosurgical procedures: a review. | clean surgical procedures carry a risk of postoperative wound infection that is less than 5% in most hospitals. the use of prophylactic antibiotic agents in clean neurosurgical cases is controversial, and the neurosurgical literature through 1980 contains no controlled clinical trials to study its effectiveness in such cases. a report of 1732 consecutive procedures without a single postoperative wound infection in patients receiving systemic gentamicin, vancomycin, and streptomycin irrigation fl ... | 1988 | 3288725 |
| psychoneurogenic stress influences upon retention of an inhibitory avoidance response in the rat. | hormones and peptides involved in the response of an organism to stress play a modulating role in learning and memory processes. we studied whether psychoneurogenic stressors such as sound stimulation or novelty influence retention of an inhibitory avoidance response. an impairing effect on retention was observed when these stressors were applied shortly after the acquisition trial, but not after a 3-h delay. however, sound stimulation and novelty applied shortly before the retention test may fa ... | 1988 | 3345185 |
| structural organization of the mouse mitochondrial malate dehydrogenase gene. | structural organization of the mouse mitochondrial malate dehydrogenase (ec 1.1.1.37) gene was determined by analyzing a genomic dna fragment isolated from a cosmid library. the gene is 12,000 base-pairs long and contains nine exons interrupted by eight introns of various sizes. the 5' and 3'-flanking regions, and the exact sizes and boundaries of the exon blocks including the transcription-initiation sites were determined. in the 5'-flanking region, there is neither a tata box nor a caat box. i ... | 1988 | 3379635 |
| synthesis and characterization of a radiolabelled derivative of the phencyclidine/n-methyl-d-aspartate receptor ligand (+) mk-801 with high specific radioactivity. | a [3h]-labelled derivative of the drug (+)mk-801 with a high specific radioactivity was synthesized by first preparing a tribromo derivative of (+)mk-801 followed by catalytic reduction in the presence of [3h]-gas and subsequent purification of the radioactive product by reversed-phase high performance liquid chromatography (rp-hplc). this resulted in pure (+) [3h]mk-801 with a specific radioactivity of 97 ci/mmol. the (+) [3h]mk-801 was shown to interact with high affinity and selectivity with ... | 1988 | 2845205 |
| naloxone attenuation of sham feeding is modified by manipulation of sucrose concentration. | the time course of sucrose (5, 10 and 20%; w/v) sham feeding was monitored in one hour tests. intake levels increased as a function of concentration. naloxone (1.25 mg/kg, ip) attenuated the sham feeding of 10% sucrose solution in gastric fistulated rats, without affecting initial intake rates. furthermore, after naloxone the intake pattern of 10% sucrose was identical to that for 5% sucrose in untreated rats. in a second test, substitution of 10% sucrose by a 20% solution after 15 min of sham f ... | 1988 | 2853384 |
| monoclonal antibody ery-1 identifies an antigen in erythroid cells, hepatocellular and renal cell carcinomas. | we have identified a monoclonal antibody (ery-1), which reacts with erythrocytes, erythroid precursor cells, and with embryonal yolk sac, and normal liver and kidney. the antibody also decorates the neoplastic cells of hepatocellular, renal, and yolk sac carcinomas. no reactivity was seen in a variety of other epithelial or mesenchymal neoplasms. it is possible that ery-1 recognizes an erythropoiesis-associated antigen present in yolk sac, kidney, liver, and bone marrow, all of which are involve ... | 1988 | 2829493 |
| effects of almitrine on respiration in unanesthetized newborn rabbits. | we previously demonstrated that almitrine, a peripheral chemoreceptor stimulant, increased tidal volume (vt), expired minute ventilation (ve), and respiratory frequency (f) and decreased inspiratory (ti) and expiratory time (te) in sleeping adult cats. we now hypothesized that almitrine would induce an increase in ventilation in a young animal model. respiration was studied by the barometric method in 11 unanesthetized new zealand white rabbit pups between 3 and 6 days of age. recordings were ma ... | 1988 | 2897355 |
| use of restriction fragment length polymorphisms (rflps) to distinguish between nematodes of pathogenic significance. | the availability of restriction fragment length polymorphisms (rflps) would be useful for studying the extent of diversity among morphologically indistinguishable populations of filarial parasites. such polymorphisms may be useful in correlating various physiological and clinical differences with parasite heterogeneity. in order to identify such rflps, we isolated dna from microfilaria of 6 filarial species (acanthocheilonema viteae, brugia malayi, brugia pahangi, dirofilaria immitis, litomosoid ... | 1988 | 2897655 |