Publications

oxygen consumption of the germinal epithelium in psoriatic human skin as measured by the cartesian diver micro-gasometer.		1968	4185292
some pharmacological properties of a synthetic oxytocin analogue [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), an antagonist to the neurohypophysial hormones.	1. a synthetic oxytocin analogue, [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), has been tested as an antagonist to the actions of oxytocin and vasopressin on the uterus, the mammary gland and blood pressure.2. the analogue inhibited the response of the isolated rat uterus to both oxytocin and vasopressin without itself stimulating the uterus to contract. the responses to equipotent doses of oxytocin and vasopressin were inhibited equally. there was little o ...	1970	4321760
some pharmacological properties of a synthetic oxytocin analogue [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), an antagonist to the neurohypophysial hormones.	1. a synthetic oxytocin analogue, [1-n-carbamoyl-hemicystine-2-o-methyltyrosine]-oxytocin (carbamoyl-methyloxytocin), has been tested as an antagonist to the actions of oxytocin and vasopressin on the uterus, the mammary gland and blood pressure.2. the analogue inhibited the response of the isolated rat uterus to both oxytocin and vasopressin without itself stimulating the uterus to contract. the responses to equipotent doses of oxytocin and vasopressin were inhibited equally. there was little o ...	1970	4321760
inhibition of hepatic ribonuclease activity by chronic administration of phenobarbitone.		1970	4394767
studies on the induction of serum hemopexin by pentobarbital and polycyclic hydrocarbons.		1972	4119360
striatal tyrosine hydroxylases with high and low affinity for tyrosine: implications for the multiple-pool concept of catecholamines.		1973	4148015
regulation of rat liver beta-hydroxy-beta-methylglutaryl-coa reductase activity by cholesterol.		1973	4202331
antigen-binding cells following contact-sensitization detected by rosette-formation. characterization of the receptors by inhibition of rosette-forming cells with anti-rabbit allotype and anti-class specific antisera.		1973	4541103
the representation field of the parental neurons of afferent fibers of the lacrimal nerve in the trigeminal ganglion in rabbits.		1973	4541376
[histotopography of phosphatases during the development of the rat retina and their disorders indiced by x-rays].		1973	4701668
suppressor cells in the rabbit appendix.		1974	4547314
[effect of x-rays on human adult skin explants].		1975	1233920
the possible role of tightly bound adenine nucleotides in oxidative and photosynthetic phosphorylation.	the tightly bound nucleotides of the beff-heart mitochondrial atpase are released during cold inactivation followed by ammonium sulfate precipitation. during incubation at 0 degrees c the sedimentation coefficient (s20w) of the atpase first declines from 12.1s to 9s. prolonged incubation or precipitation with ammonium sulfate leads to dissociation of the 9s component into subunits with s20w of 3.5s. the 9s component still bears bound nucleotides which exchange more extensively and rapidly with a ...	1975	127089
biologic activity of soluble collagen-anticollagen immune complexes as demonstrated by passive cutaneous anaphylaxis.	collagen-anticollagen immune complexes were prepared by gel filtration. complex formation was chemically and serologically demonstrated. complexes eluting in gammam- and gammag-peaks of antigen-antiserum mixture showed strong positive reactions in pca experiments performed with 20 guinea pigs. control preparations of gammam- and gammag-peaks of antiserum devoid of antigen gave significantly lower pca-response. the positive reaction of control preparations can be explained in part by a certain de ...	1975	127469
effectiveness of orally administered bordetella pertussis vaccine in mice.	oral administration of killed bordetella pertussis organisms to mice results in increased resistance to an intracerebral infection with virulent b. pertussis cells. the rate of survival is dependent on the dose of antigen. but besides specific systemic immunity, which is persistent over a long period, also transient non-specific resistance is increased. these effects are evidently induced without penetration of bacterial substances into the circulation.	1976	182602
effect of repeated bloodletting on the incidence of 2,7-faa-induced rat leukemia.	the oral administration of n,n'-2,7-fuorenylenebisacetamide (2,7-faa) induced leukemia, especially mature granulocytic leukemia, in rats. 2,7-faa was administered to the rats of the wistar strain and a small amount of bloodletting was repeated for a long period. the incidence of leukemia and mature granulocytic leukemia became elevated by bloodletting. the induction of mature granulocytic leukemia might be increased by the promotion of granulopoiesis which had been suppressed by 2,7-faa.	1976	1068628
the effect of mechanical stretching of the myosin rod component (fragment lmmmm s-2) on the atpase activity of myosin.	the binding of myosin to nylon fiber gives immobilized myosin with a considerable atpase activity. treatment of immobilized enzyme with papain results in the entire atpase activity (known to be concentrated in myosin heads, (fragment hmm s-1)) being replaced from the fiber into the solution; this means that myosin is chemically bound to the fiber via its rod part (fragment lmm+hmm s-2). when nylon fiber is mechanically stretched, the atpase activity of myosin attached to it sharply decreases; af ...	1978	149560
passage of immunoglobulins from plasma to the oral cavity in rhesus monkeys.	the passage of immunoglobulin from plasma to the oral cavity was studied in rhesus monkeys. immunoglobulins g, a and m were purified from pooled rhesus monkey serum, radiolabelled with 125i and injected intravenously into twelve monkeys. sequential samples of oral fluids were taken over a 24 h period and were assayed for radioactivity. radioactivity could be detected in crevicular fluid washings after 0.5 h in monkeys injected with igg and iga, and after 2 h in monkeys given igm. maximal levels ...	1978	104924
immunochemical studies of guinea pig progesterone-binding plasma protein.	an antiserum specific for guinea pig progesterone-binding plasma protein (pbp) has been prepared. using a very sensitive immunoenzymatic assay, pbp could be detected not only in pregnant guinea pig plasma (970 microgram/ml of plasma at day 40--60 of pregnancy), but also in the plasma of fetuses (2.77 micrograms/ml), umbilical arteries (1.79 micrograms/ml), umbilical vein (2.90 micrograms/ml), and in amniotic fluid (0.47 microgram/ml). the protein was also found in low concentration in the plasma ...	1978	85546
pattern of milk flow in breast-fed infants.	122 six-day-old infants were test-weighed during breast feeding. cross-sectional data collection avoided repeated interruptions of individual feeds. milk flow conformed to a definite pattern: a mean of 50% of the feed from each breast was taken in the first two minutes of sucking and a mean of 80-90% was taken by four minutes. the second half of a ten-minute feed from either breast was almost non-nutritive. preliminary studies suggest that the pattern is the same after one month of lactation.	1979	87962
benign prostatic hyperplasia in an xx man.	a sixty-nine-year-old white phenotypic male who was being investigated for a myeloproliferative disorder, was found to have an xx karyotype in all cells examined in bone marrow, lymphocytes, and skin fibroblast cultures. despite essentially no testosterone in the plasma, he also suffered from severe prostatic hyperplasia, a finding not reported previously in patients with this genotype. while endocrine studies showed normal follicle-stimulating hormone, the luteinizing hormone level was twice th ...	1979	88115
studies on histamine release induced by compound 48/80 and peptide 401 [proceedings].		1979	88890
distribution of myosin isoenzymes among skeletal muscle fiber types.	using an immunocytochemical approach, we have demonstrated a preferential distribution of myosin isoenzymes with respect to the pattern of fiber types in skeletal muscles of the rat. in an earlier study, we had shown that fluorescein-labeled antibody against "white" myosin from the chicken pectoralis stained all the white, intermediate and about half the red fibers of the rat diaphragm, a fast-twitch muscle (gauthier and lowey, 1977). we have now extended this study to include antibodies prepare ...	1979	90047
the use of avidin-biotin interaction in immunoenzymatic techniques.	biotin was covalently attached to antibodies, antigens and enzymes, and the effects of this labeling on the antigen and antibody binding capacity and on enzymatic activity were tested. based on avidin-biotin interaction, the labeled proteins were used in quantitative enzyme-immunoassay and enzyme-immunohistochemical staining procedures. two procedures were developed. in the first procedure, named the bridged avidin-biotin (brab) technique four steps were used sequentially in order to quantify or ...	1979	90074
the indirect rat mast cell degranulation test reconsidered.	the indirect rat mast cell degranulation test for the detection of human reaginic antibodies was reinvestigated. when the mast cells were incubated with human reaginic serum at concentrations exceeding approximately 3%, a massive, non-specific histamine release occurred, irrespective of the presence or absence of allergen. at tolerated serum concentrations (below 3%), the allergen concentration did not influence the release process. we conclude that the indirect rat mast cell test is not applica ...	1979	90655
a 16-fold semi-microelectrode for intracortical recording of field potentials.	a 16-fold semi-microelectrode with 10 x 10 sq. microns contacts at distances of 150 microns, produced by means of thin-film technology, is described. these small dimensions are required to study the laminar electrophysiological differences within the cerebral cortex.	1979	91493
comparison of antigen-specific i-region-associated cell interaction factors.	two basic types of factors reacting with anti-i region (anti-ia) antisera are compared, those derived from macrophage-like antigen presenting cells and others derived from t-lymphocytes, of either the suppressor or helper type. despite the common property of reacting with anti-ia antisera, the two sets of factors differ by many criteria. macrophages, upon culture with antigen, release complexes of ia antigen and a fragment of the original immunogen. this material is only produced by responder ma ...	1979	93870
presence of the asialoglycoproteins-binding protein in primary monolayer culture of adult rat hepatocytes [proceedings].		1979	93914
analysis of anti-sperm sera for t/t locus-specific antibody.	an objective antiglobulin radioimmunoassay for the analysis of anti-spermatozoa antisera has been used to characterize more than 30 alloantisera. each of these antisera was raised against spermatozoa from mice carrying t/t regin mutations. whilst all of the antisera had considerable activity for mouse spermatozoa, none of them was found to contain antibodies specific for t/t region gene products. a detailed analysis of a single serum revealed that its activity is for antigens which are non-polym ...	1979	95255
highly purified insulins.		1979	85008
comparative study of aggressive behaviour after injection of cholinomimetics, anticholinesterases, nicotinic, and muscarinic ganglionic stimulants into the cerebral ventricles of conscious cats: failure of nicotinic drugs to evoke aggression.		1979	106424
taxonomy of anaerobes: present state of the art.	results of nucleic acid studies, which indicate relationships among strains and species more clearly than do usual phenotypic tests, have led to new bacteriologic nomenclature. some major changes in bacteroides include the recognition of three species (bacteroides melaninogenicus, bacteroides denticola, and bacteroides loescheii) formerly grouped in b. melaninogenicus subspecies melaninogenicus; two species (bacteroides intermedius with two closely related homology groups and bacteroides corpori ...	1984	6201990
comparison of strains of gram-negative, anaerobic, agar-corroding rods isolated from soft tissue infections in cats and dogs with type strains of bacteroides gracilis, wolinella recta, wolinella succinogenes, and campylobacter concisus.	a total of 64 strains of gram-negative, asaccharolytic, anaerobic, agar-corroding, rod-shaped bacteria from soft-tissue infections of cats and dogs were compared with other agar-corroding, anaerobic organisms isolated from human periodontal pockets (wolinella recta atcc 33238t), bovine rumens (wolinella succinogenes atcc 29543t), and gingival crevices of humans (bacteroides gracilis atcc 33236t and bacteroides ureolyticus nctc 10941t). campylobacter concisus atcc 33237t (from human gingival crev ...	1984	6490858
bacteroides gracilis, an important anaerobic bacterial pathogen.	clinical isolates of agar-pitting, formate-fumarate-requiring, anaerobic gram-negative bacilli were recharacterized in consideration of the species descriptions of bacteroides ureolyticus and the newly described b. gracilis, campylobacter concisus, and wolinella sp. during an 11-year period, 7.5% (101 of 1,341) of all specimens yielding anaerobes were found to contain an organism in this group. of the 71 isolates that were available for study, 43 were b. ureolyticus, 23 were b. gracilis, and 5 w ...	1985	4056006
the sfia11 mutation prevents filamentation in a response to cell wall damage only in a reca+ genetic background.	n-alpha-palmitoyl-l-lysyl-l-lysine dihydrochloride ethyl ester (pll) at sublethal doses causes filamentous growth of e. coli strains except sfia mutants, which divide normally in its presence. pll does not elicit the sos responses as judged by lambda prophage induction, an increase of reca protein synthesis or induction of the sfia operon in a sfia::lacz fusion strain. thus, it appears that filamentation caused by pll is not an sos function and might be the result of membrane damage by pll, whic ...	1985	3911030
canine brucellosis in a household.	three cases of canine brucellosis from the same household were discovered during a serosurvey of privately owned dogs. one dog was found to be seropositive and culture-positive, 1 dog was seropositive, and 1 dog had suspect test results, with eye lesions suggestive of brucella canis infection. all dogs had signs seen with b canis infection, but none was pathognomonic. although pathologic findings in 2 of the dogs were consistent with findings reported by other investigators, none was conclusive ...	1985	3921503
[significance of synthetic calcium phosphate ceramics as a bone replacement material].	with reference to the chemical and crystallographic differences, the line is drawn against bone substitute material produced from biological material. extensive animal experiments demonstrated the good healing properties when using calcium phosphate ceramics in bony defects. in the long term, there was more new bone formed after filling up the defect with calcium phosphate ceramics than when using autologous bone grafts. clinically, there is an indication for using this material to fill up bone ...	1986	3960537
[significance of synthetic calcium phosphate ceramics as a bone replacement material].	with reference to the chemical and crystallographic differences, the line is drawn against bone substitute material produced from biological material. extensive animal experiments demonstrated the good healing properties when using calcium phosphate ceramics in bony defects. in the long term, there was more new bone formed after filling up the defect with calcium phosphate ceramics than when using autologous bone grafts. clinically, there is an indication for using this material to fill up bone ...	1986	3960537
in vivo oxidants and pulmonary inflammation.	endotoxemia is used as a model of the adult respiratory distress syndrome in chronically instrumented awake sheep. the toxic effects of endotoxin may be mediated through inflammatory cells and the release of toxic oxidants. n-acetylcysteine (nac) inhibits the in vivo effects of endotoxemia in chronically instrumented unanesthetized sheep. nac also functions as a free radical scavenger in vitro. it is possible that the protective effects of pretreatment with nac result from nac's ability in vivo ...	1986	3697543
[lithotripsy by ultrashort pulsation. experimental study in renal lithiasis in the dog].	a lithotriptor delivering ultrashort shockwaves and designed for use under ultrasonographic guidance has recently been developed. immersion in water is unnecessary. the device was experimented in renal lithiasis in dogs. twenty-two animals were treated. in seven, who served as controls, the safety of shots delivered in particular to the lungs, liver, bones and kidneys was demonstrated. furthermore, no cardiac rhythm disorders were recorded. a human stone was implanted in 15 animals. the stone wa ...	1986	3707073
nitrogen conversion factors for the proteinaceous content of gums permitted as food additives.	nitrogen conversion factors for gum arabic (acacia senegal (l.) willd.), gum tragacanth (asiatic astragalus spp.), gum karaya (sterculia spp.), guar gum (cyamopsis spp.), locust bean (carob) gum (ceratonia spp.), tara gum (caesalpinia spp.), and xanthan gum (xanthomonas campestris) have been calculated from data for the amino acid compositions of their proteinaceous components. the factors derived differ from the arbitrary values (5.7 or 6.25) at present specified by international regulatory aut ...	1986	3743832
in vitro activities of 17 antimicrobial agents against the formate/fumarate-requiring, anaerobic gram-negative bacilli.	the in vitro activities of 17 antimicrobial agents were evaluated against 46 clinical isolates of formate/fumarate-requiring anaerobic gram-negative bacilli. strains of bacteroides ureolyticus (23) were almost uniformly susceptible to the tested antimicrobials, whereas strains of bacteroides gracilis (18) showed some striking resistance with penicillin active against only 67%, the cephalosporins active against 67%-89%, and clindamycin active against 67%. although few strains of wolinella species ...	1986	3757477
epidemiologic studies on possible health effects of intake of pyrolyzates of foods, with reference to mortality among japanese seventh-day adventists.	to elucidate the effect of intake of mutagenic and/or carcinogenic pyrolysis products of proteins and amino acids on carcinogenesis in man, we have undertaken two epidemiologic cohort studies: one concerning the possible association of broiled fish consumption with cancer and the other concerning the cancer mortality among japanese seventh-day adventists. the main findings of these studies are described.	1986	3757950
a computer-aided analysis of the effect of peripheral nerve transection on tmpase activity of substantia gelatinosa rolandi.		1986	3020818
characterization of wolinella spp., campylobacter concisus, bacteroides gracilis, and eikenella corrodens by polyacrylamide gel electrophoresis.	the small asaccharolytic, nonpigmenting gram-negative rods of the human oral cavity are difficult to differentiate from each other. protein profiles of sonicated cells of wolinella species, campylobacter concisus, bacteroides gracilis, and eikenella corrodens were obtained by sodium dodecyl sulfate-polyacrylamide gel electrophoresis and visualized with a silver stain. the gels were scanned with a laser densitometer, and the similarity of strains was computed by determining correlation coefficien ...	1986	3533976
cardiac-specific troponin-i radioimmunoassay in the diagnosis of acute myocardial infarction.	the cardiac isotype of the myofibrillar contractile protein, troponin-i, is located specifically in the mammalian heart. a sensitive radioimmunoassay has been developed to detect human and nonhuman primate cardiac troponin-i in serum down to 10 ng/ml. immunochemical cross reactivity with skeletal troponin-i was only 2% and was species nonspecific. normal patient levels of cardiac troponin-i are about 10 ng/ml. in patients with acute myocardial infarction (n = 32), serum cardiac troponin-i was el ...	1987	3591601
chronic stress in riding horses.		1987	3622452
practolol inhibits human skin fibroblast cell mat hydroxyproline accumulation.	despite being poorly absorbed practolol (n-4-2-hydroxy-3-(1-methyl-ethyl)-amino propoxy phenyl acetamine) inhibited the accumulation of cell mat hydroxyproline, a measure of collagen synthesis, by human skin fibroblasts (dt2ph) in vitro, (id50 0.8 x 10(-3) m). the degree of inhibition was dependent on the concentration of practolol used and the incubation time. neither preinitiation of collagen synthesis nor omitting ascorbic acid from the incubation medium modified this inhibitory action. in co ...	1987	3687592
characterization of the ksga gene of escherichia coli determining kasugamycin sensitivity.	in the plasmid puc8ksga7, the coding region of the ksga gene is preceded by the lac promoter (plac) and a small open reading frame (orf). this orf of 15 codons is composed of nucleotides derived from the lacz gene, a multiple cloning site and the ksga gene itself. the reading frame begins with the atg initiation codon of lacz and ends a few nucleotides beyond the atg start codon of ksga. the ksga gene is not preceded by a shine-dalgarno (sd) signal. cells transformed with puc8ksga7 produce activ ...	1987	3122846
an analysis of the effects of taurine on cellular and extracellular calcium mobilization in rabbit ear artery.		1987	3124515
the challenge of malaria vaccine: trials and tribulations.		1987	2880172
identification of an additional sendai virus non-structural protein encoded by the p/c mrna.	peptide antiserum and monoclonal antibodies have detected a previously unrecognized small non-structural protein in sendai virus-infected cells. this protein, designated x, appears to represent the c-terminal 95 amino acids of the p protein reading frame. the x protein appears to be almost as abundant as the p protein on a molar basis in vivo. no evidence of a precursor-product relationship between the x and p proteins could be found.	1987	2821189
wolinella recta, campylobacter concisus, bacteroides gracilis, and eikenella corrodens from periodontal lesions.		1987	2957486
micro in vitro test for chloroquine resistance of plasmodium falciparum: discrepancies attributable to batch variation of plates.		1987	3318026
pulsatile secretion of growth hormone and insulin in relation to feeding in rats.	in unrestrained male wistar rats chronically implanted with intracardiac catheters, blood samples were taken every 20 min throughout the 24 h of the diurnal cycle. plasma concentrations of growth hormone (gh), insulin, and glucose were measured. the pattern of food intake was continuously monitored. the existence of 3-h pulsatile cycles of gh secretion was confirmed. in addition, short bursts of insulin secretion were observed in the middle of every second gh peak-to-peak interval. food intake a ...	1987	3318507
effect of treatment with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine/mptp/on mouse substantia nigra in vitro. fluorescence and electron microscopic examination.		1987	3501590
cell division promoting activity of naturally occurring dehydrodiconiferyl glucosides: do cell wall components control cell division?	naturally occurring isomers of the dehydrodiconiferyl glucosides have been isolated from vinca rosea crown gall tumors and have been tested for cell division promoting activities in the tobacco pith and leaf assay systems. the enantiomeric isomers a and b are active, although they are required at concentrations up to 2 orders of magnitude higher than zeatin riboside to promote comparable growth. we estimate that the active dehydrodiconiferyl glucosides are present in rapidly growing tissues (tum ...	1987	3469655
effects of hormone deprivation on the karyometric development of the medial and lateral preoptic area of the male mouse. ii. hypothyroidism.	we have analysed the karyometric development of the medial and lateral preoptic area of the hypothalamus in two groups of experimentally hypothyroid male mice, from the 25th to the 160th postnatal day. in one group, animals were treated with propylthiouracil from birth until the day of sacrifice. in the second experimental group animals were treated only until the 35th postnatal day, and thereafter sacrificed at the 45th, 55th, 85th and 160th postnatal day. we compare the results of both groups ...	1987	3440835
[human chorionic prealbumin: its identification, physicochemical properties and detection in the blood serum in trophoblastic disease].	human chorionic prealbumin (hcpa) was immunochemically identified and isolated in pure form from immature placenta, particularly, from chorion. comparative immunodiffusion analysis shows that hcpa differs from the known placenta-specific proteins. hcpa is a glycoprotein with mw about 100 kd determined by gel-filtration and 45 kd by sds polyacrylamide gel electrophoresis. by immunodiffusion hcpa was not found in fetal and adult tissues and in biological fluids. hcpa was discovered in patients wit ...	1988	2848598
[role of alpha-1 and alpha-2-adrenoreceptors in achieving the compensatory response of the hemostasis system to plasmin].		1988	2849566
the effect of metoclopramide treatment on diabetic cystoparesis.		1988	2897479
regional localization of cd18, the beta-subunit of the cell surface adhesion molecule lfa-1, on human chromosome 21 by in situ hybridization.	the gene coding for the beta-subunit of the cell surface adhesion glycoprotein lfa-1 has been localized to the tip of the long arm of chromosome 21 at 21q22.1-qter.	1988	3073708
synthetic aci-reductones: 3,4-dihydroxy-2h-1-benzopyran-2-ones and their cis- and trans-4a,5,6,7,8,8a-hexahydro diastereomers. antiaggregatory, antilipidemic, and redox properties compared to those of the 4-substituted 2-hydroxytetronic acids.	synthetic procedures for the elaboration of aci-reductones belonging to the 6- or 7-mono- or bis-substituted-3,4-dihydroxy-2h-1-benzopyran-2-ones (6-10) and their cis- and trans-4a,5,6,7,8,8a-hexahydro diastereomers (11, 12) are described. hexahydrobenzopyranone aci-reductones were conveniently prepared by using meldrum's synthon (2,2-dimethyl-1,3-dioxane-4,6-dione, 49). certain of these substances were evaluated for antilipidemic activity in the cholesterol-fed rat model, and all analogues were ...	1988	3133477
[effect of eicosanoids on the accumulation of cholesterol and the proliferation of subendothelial cells in the human aorta].	the effect of prostacyclin and stable thromboxane analog a2 on endothelial culture of human aorta was studied. it was shown that prostacyclin inhibited accumulation of cholesterol in the cells and their proliferation, while thromboxane exhibited an opposite effect. calcium antagonists potentiated effects of prostacyclin and inhibited them in respect to thromboxane. screening of a number of synthetic agents affecting arachidonic acid metabolism was carried out. it was found that lipoxygenase inhi ...	1988	3122858
fetal cortical transplants reduce the thalamic atrophy induced by frontal cortical lesions in newborn rats.	fetal neocortical tissue was grafted into frontal cortex lesion cavities made in newborn rats. after survival periods extending up to 14 months, volumetric measurements of the total thalamus and of the lateral, medial and anterior thalamic compartments showed an amelioration of the thalamic atrophy that normally is found after cortical lesions. these results correspond to previous findings demonstrating interconnections between fetal cortical transplants and the host thalamus.	1989	2710397
fetal cortical transplants reduce the thalamic atrophy induced by frontal cortical lesions in newborn rats.	fetal neocortical tissue was grafted into frontal cortex lesion cavities made in newborn rats. after survival periods extending up to 14 months, volumetric measurements of the total thalamus and of the lateral, medial and anterior thalamic compartments showed an amelioration of the thalamic atrophy that normally is found after cortical lesions. these results correspond to previous findings demonstrating interconnections between fetal cortical transplants and the host thalamus.	1989	2710397
an evaluation of the multiple-breath nitrogen washout as a pulmonary function test in dairy cattle.	multiple-breath nitrogen washouts (mbnw) were performed with 21 adult dairy cows (seven normal cows tested on two days each, four clinically normal cows tested on six days, and ten cows with respiratory disease tested on one day each). the functional residual capacity (frc), lung clearance index (lci), becklake index (bi), mixing ratio (mr), pulmonary n2 clearance delay (pcd), index of distribution of inspiration (idi) and ventilatory efficiency (eff) were calculated for each mbnw. the lci, mr, ...	1989	2713778
selective medium for isolation of bacteroides gracilis.	a new medium selective for bacteroides gracilis was developed. the medium is tryptic soy agar (difco laboratories, detroit, mich.) containing nalidixic acid, teicoplanin, sodium formate, sodium fumarate, and potassium nitrate. all 18 strains of b. gracilis tested grew with only minimal inhibition. most of the other 214 organisms tested, including most bacteroides species, other anaerobes, and a substantial number of facultative anaerobes, were significantly inhibited by the medium. in a diagnost ...	1990	2144297
in-vitro susceptibilities of bacteroides gracilis, fusobacterium mortiferum and f. varium to 17 antimicrobial agents.		1990	2211439
effects of the methyl xanthine s 9795 on isolated bronchi of the dog.	the xanthine derivative 1-methyl 3-isobutyl 8-(2-ethyl[1-(4-diphenylmethyl piperazinyl)])3, 7-dihydro (1h) purine 2, 6-dione (s 9795) is a potent inhibitor of bronchoconstriction in vivo. the aim of the present study was to analyze the effects of s 9795 in vitro and determine whether s 9795 affects the autonomic nerves, the epithelium or the smooth muscle of the bronchial wall. s 9795 had an inhibitory effect on the contractile responses evoked by acetylcholine and by electrical stimulation of t ...	1990	2395105
revision of campylobacter, helicobacter, and wolinella taxonomy: emendation of generic descriptions and proposal of arcobacter gen. nov.	hybridization experiments were carried out between dnas from more than 70 strains of campylobacter spp. and related taxa and either 3h-labeled 23s rrnas from reference strains belonging to campylobacter fetus, campylobacter concisus, campylobacter sputorum, campylobacter coli, and campylobacter nitrofigilis, an unnamed campylobacter sp. strain, and a wolinella succinogenes strain or 3h- or 14c-labeled 23s rrnas from 13 gram-negative reference strains. an immunotyping analysis of 130 antigens ver ...	1991	1704793
atypical structure of the 23s ribosomal rna molecule in certain oral bacteria.	ribosomal rna (rrna) isolated from wolinella recta and seven related bacteria was examined by agarose gel electrophoresis. the 23s rrna molecule could not be detected in w. recta, wolinella curva, bacteroides gracilis, or bacteroides ureolyticus. in place of the 23s molecule, there were three smaller molecules of approximately 1700, 650, and 600 bases designated 23s alpha, 23s beta, and 23s delta, respectively. an intact 23s rrna molecule could be isolated from wolinella succinogenes, campylobac ...	1991	1710629
comparative in vitro activity of cefpodoxime against anaerobes other than bacteroides fragilis.	to assess the in vitro activity of cefpodoxime against anaerobic respiratory tract and oropharyngeal pathogens 77 strains belonging to 18 gram-negative and 7 gram-positive species were studied by means of agar dilution tests. for comparison cefuroxime, amoxicillin, amoxicillin + clavulanic acid and clindamycin were also tested. cefpodoxime was found to be active at concentrations of less than or equal to 0.125 mg/l against prevotella oralis, prevotella buccalis, prevotella bivia, porphyromonas a ...	1991	1800380
wolinella recta, wolinella curva, bacteroides ureolyticus, and bacteroides gracilis are microaerophiles, not anaerobes.	although the nonfermentative, asaccharolytic, putative anaerobes wolinella curva, wolinella recta, bacteroides ureolyticus, and bacteroides gracilis are phylogenetically related to the true campylobacters, the type strains of these species exhibited o2-dependent microaerophilic growth in brucella broth and on brucella agar. the optimum o2 levels for growth of these strains ranged from 4 to 14% in brucella broth and from 2 to 8% on brucella agar, when h2 was provided as the electron donor. no gro ...	1991	1854636
identification, and susceptibility to seven antimicrobial agents, of 61 gram-negative anaerobic rods from periodontal pockets.	sixty-one cultures of gram-negative anaerobic rods were isolated from deep periodontal pockets of patients with rapidly progressive periodontitis. isolates were speciated as bacteroides gingivalis (18 isolates), bacteroides intermedius (8), bacteroides oris (1), bacteroides gracilis (17) and fusobacterium nucleatum (17). their susceptibilities, to seven antimicrobial agents, were determined in vitro using a plate dilution technique. amoxycillin and amoxycillin with clavulanic acid were active ag ...	1991	1901873
bacteroides ureolyticus (ntu) medium for the selective recovery of bacteroides gracilis.	bacteroides gracilis is a gram-negative anaerobic bacillus which requires formate and fumarate for growth; it has been implicated in periodontal disease and serious infections of the head and neck. in this study, bacteroides ureolyticus (ntu) medium was tested for its ability to allow the growth of b. gracilis and other formate-fumarate requiring gram-negative anaerobes and to enable the recovery of these organisms from clinical specimens. all reference strains grew on ntu medium with the except ...	1991	1942000
severe illness associated with group a-hemolytic streptococcal infections.	the wisconsin division of health (doh) began surveillance for severe illnesses associated with group a beta-hemolytic streptococcus (gabs) infections in late 1989 to describe the current epidemiologic features and clinical spectrum of these infections in the state. severe illness was defined by the isolation of gabs from the blood or by the development of one or more of the following in a patient infected with gabs: shock, extensive tissue injury, desquamating rash, disseminated intravascular co ...	1991	1949873
multivariate analyses of cellular fatty acids in bacteroides, prevotella, porphyromonas, wolinella, and campylobacter spp.	the genera bacteroides, wolinella, and campylobacter contain several similar species that require taxonomic revision. fatty acid profiles of whole bacterial cells have proven useful for taxonomy. in this study, cellular fatty acids from bacteroides, prevotella, porphyromonas, wolinella, and campylobacter spp. were identified and quantitated by gas chromatography and gas chromatography-mass spectrometry, and the data were subjected to principal component analyses. bacteroides fragilis, the type s ...	1991	1993755
selective medium for bacteroides gracilis.		1991	1993761
presidential address: adelaide congress.		1991	269725
in vitro activity of meropenem and other agents against oral bacteria.	the susceptibility of 106 oral bacteria to meropenem, a new carbapenem antimicrobial, penicillin v, tetracycline and metronidazole was assessed by an agar dilution method. meropenem was the most effective of the antimicrobials, with all strains tested being inhibited at < or = 1 mg/l. a number of strains were resistant to penicillin v, particularly bacteroides gracilis, and tetracycline resistance was widespread amongst the streptococci tested. metronidazole was extremely effective against oblig ...	1992	1286575
microbiology of healthy and diseased periodontal sites in poorly controlled insulin dependent diabetics.	a group of poorly-controlled insulin dependent diabetes mellitus (iddm) patients were examined in a cross-sectional design for total microbial levels, microbial incidence, and the percent levels of selected periodontal microorganisms. these organisms were selected on the basis of prior reports that associated them with either periodontal disease or health. one periodontally-healthy and one periodontally-diseased site were examined in each iddm patient. increased levels of the periodontal pathoge ...	1992	1315389
cytochrome composition and oxygen-dependent respiration-driven proton translocation in wolinella curva, wolinella recta, bacteroides ureolyticus, and bacteroides gracilis.	the membrane fractions of the microaerobically grown type strains of wolinella curva, wolinella recta, bacteroides ureolyticus, and bacteroides gracilis contained membrane-bound cytochrome b, cytochrome c, and co-binding cytochrome c. soluble cytochrome c and co-binding cytochrome c were also present. although b. gracilis is oxidase negative, it possessed cytochrome c. with h2 or formate as the electron donor, proton efflux from anaerobic cells occurred upon addition of a pulse of oxygen. with f ...	1992	1325865
detubularization-induced contractile response change of the ileum following ileocystoplasty.	we reported previously that following ileocystoplasty the structure and pharmacologic response of the implanted ileum changes towards that of the bladder. specifically, the relaxation response to alpha adrenergic (methoxamine) and purinergic (atp) stimulation reverses to a contractile response one month after the ileal segment is surgically made part of the urinary bladder. the present study was designed to investigate possible signals for this change and also to determine whether bladder respon ...	1992	1351953
the early colonization of gram-negative anaerobic bacteria in edentulous infants.	the occurrence of oral gram-negative anaerobes was examined in 30 edentulous infants (mean age 3 months, range 1-7 months). one pooled swab sample from mucosal surfaces (cheeks, palate, tongue) and one saliva sample was taken from each infant. the samples were cultured aerobically and anaerobically using non-selective and selective media. prevotella (bacteroides) melaninogenica was the most frequently isolated anaerobe, found in 70% of the infants. the other common anaerobes were fusobacterium n ...	1992	1528621
effects of bradykinin on the hemodynamics of tumor and granulating normal tissue microvasculature.	bradykinin (bk) is an important endogenous mediator of microvascular flow modulation. since the structure of the microcirculation is very different in tumor tissues than in normal tissues, bradykinin may elicit different responses in tumors. this study was designed to test the hypothesis that local administration of bradykinin increases blood flow preferentially in normal tissue relative to adjacent tumor tissue, resulting in a "vascular steal" phenomenon. microvessel diameters (d), velocities ( ...	1992	1594761
vitamin e kinetics after intraperitoneal administration of dl-alpha-tocopherol and dl-alpha-tocopherol acetate in sheep.	the disposition of radiotocopherol after intraperitoneal administration of 14c-labelled-dl-alpha-tocopherol (1 microci/kg bw, dose 1) and 3h-labelled-dl-alpha-tocopherol (4 microci/kg bw dose 4) and of d-alpha-tocopherol, after intraperitoneal administration of dl-alpha-tocopherol acetate (100 mg/kg bw) was investigated in sheep. plasma samples were taken at regular intervals after dosing and assayed for radioactivity and d-alpha-tocopherol. plasma profiles were modelized using a compartmental a ...	1992	1610075
in vitro activity of bay y3118 against anaerobic bacteria.	the antimicrobial activity of a new quinolone, bay y3118, was determined against 326 strains of anaerobic bacteria and compared with the activities of ampicillin-sulbactam, cefotetan, clindamycin, imipenem, metronidazole, and sparfloxacin. the national committee for clinical laboratory standards-approved wadsworth agar dilution technique with brucella-laked blood agar was used throughout the study. breakpoints used to determine the percent susceptible were 2 micrograms/ml for bay y3118 and sparf ...	1993	8285647
characterization of an unusual microaerophilic organism closely related to bacteroides gracilis.		1993	8324116
empyema due to bacteroides gracilis: case report and in vitro susceptibilities to eight antimicrobial agents.	we describe a patient with empyema due to bacteroides gracilis and a viridans streptococcus. therapy with both cefoxitin and imipenem failed, and the patient remained symptomatic even after thoracotomy was performed. clinical response occurred after initiation of clindamycin therapy. the susceptibilities of the patient's isolate, other clinical strains, and the reference strain were determined by an agar dilution method. the isolates were generally susceptible to all the agents tested; however, ...	1993	8324129
bactericidal activity of selected antimicrobial agents against bilophila wadsworthia and bacteroides gracilis.	bactericidal assays of bacteroides gracilis (six strains) and bilophila wadsworthia (12 strains) in brucella broth with appropriate supplements were performed by the time-kill kinetic method. antimicrobial agents tested were ampicillin/sulbactam (final concentrations, 16/8 micrograms/ml), ticarcillin/clavulanate (128/2 micrograms/ml), imipenem (8 micrograms/ml), cefoxitin (32 micrograms/ml), chloramphenicol (16 micrograms/ml), clindamycin (4 micrograms/ml), and metronidazole (16 micrograms/ml). ...	1993	8324144
helicobacter acinonyx sp. nov., isolated from cheetahs with gastritis.	four strains of a novel helicobacter species were isolated from the stomachs of cheetahs (acinonyx jubilatus) with gastritis. these isolates were phenotypically similar to helicobacter pylori. the isolates were gram-negative, spiral bacteria which grew under microaerophilic conditions at 37 degrees c, but not at 25 or 42 degrees c, and produced urease, catalase, oxidase, alkaline phosphatase, and gamma-glutamyl transpeptidase. the isolates did not ferment glucose, mannitol, inositol, sorbitol, r ...	1993	8379970
in vitro activity of fk037, a new parenteral cephalosporin, against anaerobic bacteria.	the activity of fk037, a new parenteral cephalosporin, was compared with those of cefpirome, ceftazidime, and flomoxef against 322 recent clinical isolates of anaerobic bacteria. a fastidious facultative anaerobe, gardnerella vaginalis, was also studied. fk037 inhibited 90% of isolates of peptostreptococcus anaerobius, peptostreptococcus asaccharolyticus, clostridium perfringens, mobiluncus spp., g. vaginalis, and porphyromonas gingivalis at < or = 0.78 micrograms/ml. the mics of fk037 for 50 an ...	1993	8517721
[principles of personnel management].		1993	187861
the oral gram-negative anaerobic microflora in young children: longitudinal changes from edentulous to dentate mouth.	eruption of primary teeth has a great influence on the oral environment by providing suitable niches for bacterial colonization. the composition of oral gram-negative anaerobic microflora was investigated in 21 young children (mean age 32 months) with primary dentition. the bacterial findings of samples were compared with those of the same children collected at their edentulous infant period (mean age 3 months). during the primary period, 2 samples were collected from each child: a sample with d ...	1994	7936718
in vitro activity of meropenem compared with imipenem, metronidazole, ampicillin, and ampicillin/sulbactam against anaerobes.	the aim of the present study was to compare the in vitro activity of meropenem (ici 194660, cas 96036-03-2) with imipenem, metronidazole, clindamycin, ampicillin and ampicillin/sulbactam against a variety of anaerobic bacteria using an agar dilution method. 423 clinical isolates were tested belonging to 70 species of 15 anaerobic genera. they included bacteroides fragilis (n = 62), bacteroides thetaiotaomicron (n = 45), prevotella bivia (n = 11), fusobacterium nucleatum (n = 12), clostridium per ...	1994	7945523
the most frequently isolated gram-negative anaerobes in saliva and subgingival samples taken from young women.	stimulated saliva and a pooled subgingival sample from the first molars were collected from 30 caucasian women (mean age 30 years) for the presence of gram-negative anaerobic bacteria. the samples were inoculated on nonselective and selective media. the gram-negative anaerobic species occurring in the oral cavity of more than 50% of the subjects were selected for further analysis. fusobacterium nucleatum and prevotella melaninogenica were not recovered from subgingival sites without a simultaneo ...	1994	8008430
inactivation of anaerobic bacteria by various photosensitized porphyrins or by hemin.	the photodynamic effects of deuteroporphyrin (dp), hematoporphyrin derivative (hpd), hematoporphyrin (hp), or protoporphyrin (pp) on a variety of anaerobic microorganisms were examined in this study. the majority of the species, among the 350 strains tested, were inhibited by concentrations of < or = 2.5 micrograms/ml of light-activated dp. species found to be resistant to this treatment included bilophila wadsworthia, fusobacterium mortiferum, fusobacterium varium, and bacteroides gracilis. the ...	1994	7765091
chemotaxonomic analyses of bacteroides gracilis and bacteroides ureolyticus and reclassification of b. gracilis as campylobacter gracilis comb. nov.	the cellular fatty acids, respiratory quinones, and proteins of the generically misnamed taxa bacteroides gracilis and bacteroides ureolyticus were analyzed and compared with the corresponding chemotaxonomic features of their closest relatives, the campylobacters. our results and previously published data for genotypic and phenotypic characteristics were used in a polyphasic approach to reconsider the classification of these organisms. we transfer b. gracilis to the genus campylobacter as campyl ...	1995	7857794
differentiation of bacteroides gracilis, bacteroides gracilis-like organisms, and campylobacter species on the basis of dehydrogenase patterns.		1995	7548533