Publications

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genetic diversity of imjin virus in the ussuri white-toothed shrew (crocidura lasiura) in the republic of korea, 2004-2010.recently, imjin virus (mjnv), a genetically distinct hantavirus, was isolated from lung tissues of the ussuri white-toothed shrew (crocidura lasiura) captured near the demilitarized zone in the republic of korea. to clarify the genetic diversity of mjnv, partial m- and l-segment sequences were amplified from lung tissues of 12 of 37 (32.4%) anti-mjnv igg antibody-positive ussuri white-toothed shrews captured between 2004 and 2010. a 531-nucleotide region of the m segment (coordinates 2,255 to 2, ...201121303516
divergent ancestral lineages of newfound hantaviruses harbored by phylogenetically related crocidurine shrew species in korea.spurred by the recent isolation of a novel hantavirus, named imjin virus (mjnv), from the ussuri white-toothed shrew (crocidura lasiura), targeted trapping was conducted for the phylogenetically related asian lesser white-toothed shrew (crocidura shantungensis). pair-wise alignment and comparison of the s, m and l segments of a newfound hantavirus, designated jeju virus (jjuv), indicated remarkably low nucleotide and amino acid sequence similarity with mjnv. phylogenetic analyses, using maximum ...201222230701
biodiversity and evolution of imjin virus and thottapalayam virus in crocidurinae shrews in zhejiang province, china.the recent discovery of numerous hantaviruses in insectivores has provided a new view of hantavirus biodiversity and evolution. to determine the presence and genetic diversity of imjin virus (mjnv) and thottapalayam virus (tpmv) in insectivores in zhejiang province, china, we captured and performed virus screening of 32 ussuri white-toothed shrews (crocidura lasiura) and 105 asian house shrews (suncus murinus) in different coastal regions. hantavirus genome (s, m, and l segments) sequences were ...201424874196
lethal disease in infant and juvenile syrian hamsters experimentally infected with imjin virus, a newfound crocidurine shrew-borne hantavirus.to gain insights into the pathogenicity of imjin virus (mjnv), a newfound hantavirus isolated from the ussuri white-toothed shrew (crocidura lasiura), groups of syrian hamsters (mesocricetus auratus) of varying ages (<1, 5, 10, 14, 21, 35 and 56 days) were inoculated by the intraperitoneal route with 1000 pfu of mjnv strains 04-55 and 05-11. mjnv-infected syrian hamsters, aged 21 days or less, exhibited reduced activity, weight loss, respiratory distress, hind-limb paralysis and seizures. death ...201526371066
detection of imjin virus and seoul virus in crocidurine shrews in shandong province, china.recently, hantaviruses have been discovered in insectivores in europe, asia, africa, and north america. imjin virus (mjnv) was first isolated from the lung tissues of ussuri white-toothed shrew (crocidura lasiura) from south korea in 2009. we aim to detect the species and prevalence of insectivore- and rodent-borne hantaviruses in shrews and rodents.201728287930
dynamic circulation and genetic exchange of a shrew-borne hantavirus, imjin virus, in the republic of korea.hantaviruses (family bunyaviridae) are enveloped negative-sense tripartite rna viruses. the natural hosts of hantaviruses include rodents, shrews, moles, and bats. imjin virus (mjnv) is a shrew-borne hantavirus identified from the ussuri white-toothed shrews (crocidura lasiura) in the republic of korea (rok) and china. we have isolated mjnv and determined its prevalence and molecular diversity in gyeonggi province, rok. however, the distribution and phylogeography of mjnv in other regions of rok ...201728295052
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