Publications

contributions of a clinical genetics laboratory to the diagnosis and treatment of disease in childhood.		1963	14045779
five new viral exanthems.		1964	14180572
laboratory service for influenza and other respirovirus diseases.		1967	6020911
first questions. presidential address. human factors society.		1968	5662637
a chromosome survey of 2,400 normal newborn infants.		1969	5764778
studies with inactivated influenza vaccines purified by zonal centrifugation. 2. efficacy.	high (3000 cca units) and standard low (300 cca units) doses of the monovalent purified vaccines described in an earlier paper were evaluated in a double-blind manner in 2 adult populations for protective effectiveness against illness caused by the hong kong influenza virus. epidemics in both populations occurred 4-6 weeks after single injections of vaccine were given.the attack rates among recipients of low or high doses of a2/japan vaccines in a prison were virtually identical to those among t ...	1969	5309468
human influenza: aspects of the immune response to vaccination.		1969	4184389
hospital-associated infections.		1969	4980611
spoke design for inpatient care. designing for nursing efficiency: a multidisciplinary evaluation.		1970	5494265
dental asymmetry as an indicator of genetic and environmental conditions in human populations.		1970	5509692
a study of human aortic distensibility with relation to atherosclerosis and aging.		1971	5092609
influenza and neural-tube defects.		1971	4105702
a course in human sexuality for the college student.	since 1967, 5000 students at albertus magnus, amherst, brown, dartmouth, mt. holyoke, smith, and the university of massachusetts have participated in a sex education course, "topics in human sexuality." the course format is shaped by critiques of past students. a series of 6-8 lectures, delivered by the authors, covers basic areas such as psychosexual development, interpersonal relationships, sexual response, pregnancy and birth, contraception, and abortion. the students have declared a desi ...	1971	4111063
large nematode larva from the abdominal cavity of a man in massachusetts.		1972	4635776
maternal health and mongolism.	preliminary findings of an analysis of the occurrence of mongolism among 25,000 babies born in framingham, massachusetts, in the 12-year period from 1960-1971 are reported. during the 12 years, 31 mongoloid babies were born to residents, and 12 (39%) were born in the 2-year period of 1970 and 1971, with the rate of mongolism approaching 5/1000 births in 1971 despite an overall decline in the birth rate. maternal health factors and clinical tests of the offspring (karyotyping, x-ray, and photogra ...	1972	4114213
research on prisoners.		1973	4697951
the mental hospital in the era of human services.		1973	4714924
temporal laws and medical ethics in conflict.		1973	4718042
suicide in the aging. suicidal behavior in a 70-year-old man: a case report.		1973	4750469
physician extraordinary--a foe of man-made diseases.		1973	4572651
excursions into epidemiology: selected studies during the past four decades at boston city hospital.		1973	4577976
joseph garland, m.d., 1893-1973. the man, his family and friends.		1973	4579335
epidemics of anencephalus and spina bifida in ireland since 1900.		1973	4591345
abortion and the law: equal protection.		1973	11663435
family planning services and population research act.	the senate human resources subcommittee under the chairmanship of senator alan cranston has completed its work on the family planning services and population research amendments of 1973 (s. 1708) and has referred the bill to the senate labor and public welfare committee. right-to-life activists are zeroing in on committee members in hopes of amending the bill to prohibit federal funds for sterilization and continued research on abortifacient drugs. if such provisions were to be approved, it w ...	1973	12276914
an act prohibiting experimentation on human fetuses. approved 26 jun 1974.		1974	12041354
from comstockery through population control: the inevitability of balancing.		1974	11663527
foetal research aborted in united states.		1974	11664375
proceedings: epidemiology of human breast cancer.		1974	4600635
characterization of klebsiella isolates from natural receiving waters and comparison with human isolates.	two hundred sixty-six strains of klebsiella pneumoniae isolated from natural water sources in geographically diverse areas (florida, massachusetts, and oregon) were analyzed to determine the serotype, biochemical, virulence, and antimicrobial susceptibility differences between these natural strains and human klebsiella isolates. sixty of 72 defined serotypes were found among 210 typable strains. geographic patterns were present, but in general were not pronounced among serotypes. reactions with ...	1974	4607526
babesiosis in man. sixth documented case.		1974	4412160
the manifestations of abnormal hemoglobins of man: hemoglobins m.		1974	4530672
infection and antibiotic usage at boston city hospital: changes in prevalence during the decade 1964-1973.		1974	4544686
historical reflections on the sesquicentennial of the founding of the boston prison discipline society (1825-1854).		1975	779872
law-medicine notes. experimentation becomes a crime: fetal research in massachusetts.		1975	1110708
milieu process during the residency turnover: the human cost of psychiatric education.		1975	1119610
lead in human scalp hair: some factors affecting its variability.	the accumulation of lead in human scalp hair was compared in male and female children and adults from various locations in the united sates, japan, yugoslavia, iran, and south africa. the most significant variables which influenced the concentration of lead in hair were ingestion of lead-containing substances, exposure to lead of environmental origin, place of residence, site from which the hair specimen was sampled relative to its distance from the scalp, and age. the least significant variable ...	1975	1141710
respiratory colonization with pseudomonas putrefaciens after near-drowning in salt water.	pseudomonas putrefaciens, a marine organism infrequently found in human culture material, was repeatedly isolated from the sputum of a patient with pneumonia during a three-week period following a salt-water drowning accident. similar organisms were found in the water at the site of the accident in boston, and at ocean bathing beaches on nearby martha's vineyard.	1975	1163489
a comparison of two abortion-related legal inquiries.		1975	1080506
childhood lead poisoning and legislative action.		1975	1081566
isolation and characterization of vibrio parahaemolyticus from cape cod soft-shell clams (mya arenaria).	vibrio parahaemolyticus was isolated from soft-shell clams (mya arenaria) taken from 10 different clamming areas on cape cod, mass., during july and august 1972. direct plating on thiosulfate-citrate-bile salts-sucrose agar was found to be superior to either direct plating on vanderzant modified salt starch agar or enrichment with trypticase soy broth containing 7% salt for isolation from clam samples. morphological and biochemical characteristics of 33 isolates from 30 samples generally conform ...	1975	1096817
the man who was to be. introductory note to "black patient white therapist: a case report.".		1975	1099042
the politics of birth control, 1920-1940: the impact of professionals.	before the 1920s, a birth control movement arose in the united states out of socialist, feminist, and other radical groups concerned with women's rights and sexual freedom. after 1920 the birth control movement became gradually transformed into a respectable, nonradical reform cause, the recipient of large grants from big business, with women's rights secondary to an overriding concern with medical health and population control. this transformation was achieved through the professionalization of ...	1975	1102468
ethical problems in fetal research.		1975	11664449
psychosurgery in massachusetts: a task force report.		1975	11664587
fetal research iv: the living fetus and the law--the state's role.		1975	11663566
fetal research: the case history of a massachusetts law.		1975	11643258
fetal research (ii): the nature of a massachusetts law.		1975	11643261
fetal research (iii): the impact of a massachusetts law.		1975	11643265
boston md--neighbors exemplify divergent views in abortion debate.		1976	11663681
mbd, drug research and the schools: a conference on medical responsibility and community control, 13-14 feb 1976.		1976	11678140
experimentation on human fetuses prohibited; medical procedures authorized; consent; approval; civil and criminal liability and proceedings; severability.		1976	12041355
commonwealth v. edelin. 17 dec 1976.		1976	12038352
massachusetts medical society. resolution concerning the safety and freedom of doctor mikhail shtern.		1976	1107838
biomedical research: a view from the state legislature.		1976	931726
human babesiosis on nantucket island: transmission by nymphal ixodes ticks.	in order to identify potential vectors of human babesiosis (babesia microli) in southern massachusetts, i attempted to transmit the infection via nymphal ticks of that species found to be most abundant on reservoir hosts (peromyscus leucopus) in nature. mice were collected at frequent intervals throughout a year in a known enzootic focus on nantucket island, and ticks were removed by hand. ticks of only two species were present; larvae and nymphs of ixodes scapularis were about 10 times as numer ...	1976	1008124
factors involved in immunization program for swine influenza.	the decision to undertake a nationwide program of vaccination against swine influenza requires assessment of the status of immunity of those in various age groups in our population against this agent. pools of serum were collected from persons born in the years from 1889 to 1943; they were tested for hemaggultinin inhibiting (hi) antibody against the hsw 1n1 influenza virus strains isolated in 1931 and 1976. the titers secured serve as an indication of the average level of immunity of those of d ...	1976	1034440
letter: lawyers, doctors and patients' rights.		1976	1244559
family planning during psychiatric hospitalization.	ongoing experience with development of family planning programs in psychiatric hospitals suggests that models must be flexible to allow for varying structures and traditions of institutions and for special needs of specific patient populations. however some issues, particularly those related to patients' rights and to usefulness of particular contraceptives, are broadly applicable. introduction of a family planning program for psychiatric patients is described.	1976	1247094
renal transplantation: a twenty-five year experience.	boston has played a significant role in the development of renal transplantation. in boston was performed the first successful isograft between identical twins (1954) the first successful allograft between fraternal twins (1959) and the first successful allograft from a cadaveric donor (1962). an immunosuppressive drug was also described in boston by hematologists schwartz and dameschek (1959) and modified for renal transplantation in dogs (1961) and used for the first time in a human recipient ...	1976	791162
general washington and the patriot soldiers. they won a war with little food. a bicentennial study.	the troops in the first action of the american revolution in massachusetts were well provisioned through the efforts of joseph trumbull of connecticut, whom the second continental congress appointed commissary general, at general washingtion's request. the ration, as ordered, would have provided-by today's standards-more calories, twice as much protein, and adequate minerals and vitamins, except possible vitamin a and ascorbic acid. unfortunately, all items in the ration were seldom available to ...	1976	770557
opiate antagonists and the modification of heroin self-administration behavior in man: an experimental study.	the heroin self-administration behavior of 8 inpatient heroin addicts was examined for 10 days under blocked (i.e., following ingestion of narcotic antagonists--naloxone or naltrexone) and unblocked (no antagonist) conditions. in the unblocked state, subjects injected all the available heroin, but they ceased heroin use almost completely following antagonist administration. possible explanations for these results are discussed along with their implications for treatment.	1976	184054
diet and cancer of endocrine target organs.	the role of diet in the etiology of cancer of the breast and endometrium is considered. geographic variation in rates, effects of migration, consequences of exogenous hormone use, and other epidemiologic factors are reviewed. cancer of the endometrium is related to diet probably through simple caloric excess. the excess is reflected in obesity and the consequent overproduction of estrone, a natural but carcinogenic human estrogen. diet may also influence breast cancer risk somewhat through the s ...	1977	195711
tumor-associated antigen levels (carcinoembryonic antigen, human chorionic gonadotropin, and alpha-fetoprotein) antedating the diagnosis of cancer in the framingham study.	determinations of carcinoembryonic antigen (cea), human chorionic gonadotropin (hcg), and alpha-fetoprotein (afp) were done by use of frozen serum samples antedating the diagnosis of cancer for 9 pancreatic and 8 gastric carcinoma patients from the framingham heart study. the longest intervals for elevated antigens before cancer diagnosis were 10 months for cea and 26 months for hcg. (the single elevated afp was found in a sample 10 days before clinical diagnosis.) samples from 31 controls match ...	1977	68118
clinical spectrum of gonococcal infection in women.	the medical records of 278 women infected with neisseria gonorrhoeae during a 6-month period were reviewed. these represented 75% of the infections in women at boston city hospital during this time. women who presented to the venereal-disease clinic because they had had contact with an infected man and women who were found to be infected during routine examinations in the obstetrics-and-gynaecology clinic were usually free of symptoms or had non-specific symptoms such as vaginal discharge. howev ...	1977	68279
peer sex education training and evaluation.	human sexuality has been recognized as an important developmental, emotional, and medical concern on the college campus. the peer sex education program at the university of massachusetts/amherst has been developed as a model for the use of trained students in an educational, referral, and counseling role. this paper describes the program and outlines the methodology used in the documentation and evaluation of various program aspects. aspects described include the program's rationale and backgrou ...	1977	857687
role of midwives.	dr. alfano (new england journal of medicine 296: 1126, 1977) is certainly entitled to his personal opinions, but when they appear in a major publication in a setting that calls for factual information, they cannot go unchallenged. midwives have played and continue to play a major part in maternal-infant services in many advanced european countries. combined midwife-physician services in sweden, finland, japan, netherlands, denmark, norway, and switzerland produced infant mortality rates in 19 ...	1977	876307
boston exanthem agent: echovirus 16.		1977	920685
human babesiosis on nantucket island. clinical features.	between 20 july and 15 octoboer 1975, five cases of human infection with babesia microti were diagnosed on nantucket island, massachusetts. the illness was characterized by fever, drenching sweats, shaking chills, myalgia, arthralgia, extreme fatigue, and a mild-to-moderate hemolytic anemia. none of the patients had a history of splenetomy. although all patients responded symptomatically to treatment with oral chloroquine phosphate, parasitemia and fatigue frequently persisted for several weeks ...	1977	556920
human babesiosis on nantucket island. evidence for self-limited and subclinical infections.		1977	561308
leptospirosis in new england.	although rarely reported in humans in new england, leptospirosis is enzootic in western and central massachusetts. recently there were three cases of leptospira interrogans, serotype var pomona, in easthampton, mass. our study and others indicate a potential for waterborne epidemics in humans.	1977	578899
epidemiologic transition in the united states: the health factor in population change.	the general theory of epidemiologic transition is explained. the theory hypothesizes that long-term changes in health and disease patterns in any society are related to the demographic and social conditions in that country. mortality is considered to be the major factor in population change. the theory is illustrated by a detailed consideration of birth and death trends in the u.s. mortality decline began in the u.s. in the middle of the nineteenth century. associated with this decline was ...	1977	12335110
dr. edelin cleared by appeals court.		1977	11663717
spotlight on the staff. human relations.		1977	10235938
judges at the bedside: the case of joseph saikewicz.		1978	10289106
a child's fight for life: parents vs. doctors.		1978	10289142
u and the 4 r's: uniform reporting, rate review and regulation.		1978	10243290
student research in service agencies.		1978	11661773
the incompetent's right to die: the case of joseph saikewicz.		1978	624618
what's happening to federally aided health programs under state departments of human resources.		1978	652943
managing public health risks: the swine flu immunization program revisited.	in this comment, the massachusetts commissioner of public health views the federal government's 1976-77 swine flu immunization program, which was sharply criticized by dr. cyril wecht in a recent article in this journal, as a classic example of a public policy decision made under conditions of stress and uncertainty. once the responsible government officials had made a public commitment to immunize the entire populace of the united states, he contends, they found it very difficult to reformulate ...	1978	685984
federal preclusion of state certificate-of-need exemptions for research and education expenditures.	the national health planning and resources development act of 1974 requires each state to enact a certificate-of-need program in compliance with federal standards in order to remain eligible for continued receipt of federal funds for health resource development after 1980. this note contends that the act and related hew regulations preclude states from exempting health care facilities' research expenditures and education expenditures from the scope of the states' certificate-of-need programs. th ...	1978	685985
teaching occupational health to physicians.	a comprehensive training program for physicians interested in occupational health is presented. the objectives are to prepare students to identify and prevent occupational disease, with an emphasis on the development of a public health perspective. seven content areas are described: epidemiology and biostatistics, toxicology, industrial hygiene, safety and ergonomics, policy issues, administration, and clinical aspects. these are organized in a matrix to provide appropriate levels of training fo ...	1978	691028
eastern equine encephalitis in massachusetts, 1957-1976. a prospective study centered upon analyses of mosquitoes.	reappearance of eastern equine encephalitis (eee) in massachusetts residents in the 1970's provided an opportunity to assess the predictive value of data on rainfall, eee in horses, and carriage of eee virus (eeev) by mosquitoes, factors which had been studied annually since the last eee outbreak in 1955-1956. the cycle of multiple cases during 1973-1975 started in a second consecutive year of rainfall that exceeded the annual mean by more than 20 cm, conditions recapitulating the 1955-1956 expe ...	1978	23676
program evaluation as health services research.	evaluation of health program is necessary for more rational allocation of scarce resources. steps in evaluation include: 1)specification of the program goals, 2) description of the program, 3) definition and measurement of outcome, 4) assessment of intervening variables, 5) analysis of data, and 6) implementation of findings. examples from impirical evaluation studies are presented to illustrate one practical application of these steps. while the random controlled trial is a most powerful tool, ...	1978	281768
mortality from leukaemia and cancer in shipyard nuclear workers.	a review of death certificates in new hampshire, maine, and massachusetts for 1959-77 yielded a total of 1722 deaths among former workers at the portsmouth naval shipyard where nuclear submarines are repaired and refuelled. next of kin were contacted for 592. all deaths under age 80 were classified as being in former nuclear or non-nuclear workers depending on information supplied by next of kin. with u.s. age-specific proportional cancer mortality for white males as a standard, the observed/exp ...	1978	76937
phenotypic and epidemiologic correlates of auxotype in neisseria gonorrhoeae.	previous studies from seattle, wash., suggested that strains of neisseria gonorrhoeae which require arginine, hypoxanthine, and uracil (arg-hyx-ura- auxotype) are unifomly highly susceptible to penicillin g, are relatively resistant to complement-dependent killing by heated, pooled human serum, and are associated with disseminated gonococcal infection. for further study of the epidemiology of these strains and for analysis of the susceptibility to penicillin, serum sensitivity, and the nutrition ...	1978	98600
[the lesson of the practolol drama; can adverse effects of drugs be recognized as such sooner?].		1978	360080
castle: right man, time, and place.		1978	363006
creutzfeldt-jakob disease: patterns of worldwide occurrence and the significance of familial and sporadic clustering.	the worldwide epidemiology of creutzfeldt-jakob disease (cjd) is presented from an analysis of 1,435 patients. in the united states, the average annual mortality rate is at least 0.26 deaths per million. temporal-spatial clustering of cases was not found in the united states, but reports from other countries indicate that such clustering does occur. fifteen percent of the cases were of the familial type, suggesting a genetic susceptibility to infection. iatrogenic transmission by corneal transpl ...	1979	371520
babesia infections in man.	only recently has it been recognized that hemotropic animal parasites of the genus babesia are also human pathogens. similar to malaria in both symptoms and laboratory findings, acute babesiosis generally results in self-limited illness, but it can be fatal in the asplenic patient. the widely disseminated vector tick, ixodes dammini, can transmit infection at each stage of its development, larva and nymph as well as adult.	1979	376427
the osler medal essay: height, weight, and health: anthropometric study of human growth in nineteenth-century american medicine.		1979	389320
pandemic influenza 1918.		1979	394807
human babesiosis on nantucket island, usa: description of the vector, ixodes (ixodes) dammini, n. sp. (acarina: ixodidae).		1979	439119
age as a function in the development of sodium-related hypertension.	the populations of the developed nations of the world exhibit an increase in blood pressure with age, while in primitive societies blood pressure remains relatively constant throughout adult life. hypertension may be a complex of diseases all having the same clinical manifestations but not being caused necessarily by the same factors. a possible common denominator in the development of any chronic elevation of blood pressure is the need for the kidney to increase urine volume to promote sodium e ...	1979	510240
natural infection of dogs on cape cod with rickettsia rickettsii.	four isolates of rickettsiae from sick dogs on cape cod, mass., were serologically identical to isolates of rickettsia rickettsii from human patients with rocky mountain spotted fever. the antigenic analysis used the indirect fluorescent-antibody test and antisera prepared in mice to each of the isolates and to reference strains of r. rickettsii and rickettsia montana. serological responses of infected dogs were specific for r. rickettsii, although antibodies to r. montana were also detected in ...	1979	114534
viral exposure and autism.		1979	222139
a regional cardiac care program: planning & development.	five hospitals in northeastern massachusetts joined together to provide a cardiac care nursing educational program for staff nurses. their mutual effort reduced costs for each hospital and maximized the use of human and material resources. the endeavor has been successful, based upon a number of evaluation factors.	1979	253743
enhanced anticaries action from drinking water containing 5 ppm fluoride.	dental examinations were conducted on 1,878 adolescent schoolchildren native to seven us cities in five states, where the water was fluoride-deficient, fluoridated, or contained approximately 5 ppm of naturally occurring fluoride. dental caries experience was considerably lower in all the communities with fluoridated water than in boston, which had water deficient in fluoride, and ranged from 38% to 83% fewer mean dmf for the children in the regions with fluoridated water than for the children i ...	1979	282343
breastfeeding: volunteer counselors enter an age-old scenario.		1979	10240736