Publications

isolation of enteric viruses in ontario during 1960-1962.	during the past three years at the central laboratory, ontario department of health, 681 isolations were made in tissue culture from 6822 specimens submitted for virus studies by physicians and hospitals from all over ontario. nearly 74% of the isolates were enteroviruses, approximately 5% adenoviruses and about 1% reoviruses. the remaining 20% are still to be identified.although the bulk of isolations was made during the same three-month period (august, september and october) of each year, the ...	1963	14052975
an outbreak of aseptic meningitis due to echo 25 virus.	in a widespread outbreak of aseptic meningitis during the summer and early fall of 1961 in ontario, echo type 25 virus was found to be the predominant virus type isolated from affected patients. recovery of echo 25 virus in several cases from the csf of patients strongly suggests an etiological relationship between this virus type and the illness. the causative role of the virus was confirmed by demonstration of significant immunological response in patients found to be infected with the virus. ...	1964	14156829
enteroviral and mumps meningitis in toronto, 1963.	virological investigations of 115 children with the aseptic meningitis syndrome during 1963 resulted in the isolation of enteroviruses from cerebrospinal fluid (csf) and/or feces of 21 of 48 children who had no association with mumps. for the third successive year, echo 9 was the dominant enterovirus in cases of aseptic meningitis in toronto children, but no rashes were associated with echo 9 meningitis during 1963, in contradistinction to previous years. mumps virus was isolated from csf of 25 ...	1964	14158544
q fever in canada.	a canada-wide survey of q fever was begun in 1958 in co-operation with public health and veterinary laboratories to determine the presence and prevalence of the disease so that medical practitioners might be alerted to the potential dangers existing. serologic evidence obtained indicated that the q fever rickettsia now exists in cattle in all provinces of canada except new brunswick, nova scotia, and prince edward island. isolations of the rickettsia were obtained from bovine milk samples from o ...	1964	14175873
epidemic type a influenza in southwestern ontario in 1963.	from february to april 1963 epidemic type a influenza occurred in southwestern ontario. eighty cases were diagnosed virologically, 24 of them by isolation of virus. the epidemic strain of virus proved unusually difficult to adapt to growth in embryonated eggs, and it had low avidity for antisera. antigenically it differed from a2 strains of earlier years and belonged to the subgroup of a2 influenza viruses characterized by the a2/japan/170/62 strain. antisera to a2 strains of earlier years neutr ...	1964	14176060
red cell glucose-6-phosphate dehydrogenase deficiency--a newly recognized cause of neonatal jaundice and kernicterus in canada.	seven male newborns of chinese, greek and italian origin presented with severe hemolytic jaundice due to red cell glucose-6-phosphate dehydrogenase (g-6-pd) deficiency. in five, the hemolysis was precipitated by inhalation of mothball vapours in the home. kernicterus was evident upon admission in six infants and was fatal in four of these.g-6-pd deficiency should be suspected as a cause of jaundice in all full-term male infants of these ethnic groups. the diagnosis can be confirmed in any hospit ...	1964	14226101
sporadic occurrence of echo virus types 27 and 31 associated with aseptic meningitis in ontario.	the sporadic occurrence of echo virus types 27 and 31 in association with aseptic meningitis during the enterovirus seasons in ontario in 1959 to 1962 is reported.the etiological significance of both of these isolates was verified by demonstration of type-specific serological response in meningitis patients. echo 27, which up to now has not been encountered in association with human illness, could be added to the list of viral agents capable of causing aseptic meningitis. isolation of echo 31 fr ...	1964	14226105
ionizing radiation as an industrial health problem.	ionizing radiation, first as x-rays, later in natural form, was discovered in europe in the late 1890's. immediate practical uses were found for these discoveries, particularly in medicine. unfortunately, because of the crude early equipment and ignorance of the harmful effects of radiation, many people were injured, some fatally. because of these experiences, committees and regulatory bodies were set up to study the problem. these have built up an impressive fund of knowledge useful in radiatio ...	1964	14105012
enteroviral syndromes in toronto, 1964.	virological or serological investigations of 72 children in toronto and environs, who were hospitalized between january and october 1964 with a variety of syndromes, revealed evidence of enteroviral infection in 29 subjects. coxsackie b2 was the dominant enterovirus, being isolated from feces and/or cerebrospinal fluid (csf) of three children with aseptic meningitis, three with pleurodynia, one with myalgia and one with pericarditis; four additional patients showed rising antibody titres to this ...	1965	14269435
human trichinosis: report of four cases, with emphasis on central nervous system involvement, and a survey of 500 consecutive autopsies at the ottawa civic hospital.	in 1963, acute trichinosis was recognized in four patients at the ottawa civic hospital. one presented with cavernous sinus thrombosis and sixth nerve palsy. a second had a severe systemic infection with myocarditis; the signs of myocarditis appeared in the third week. electrocardiographic abnormalities included t-wave flattening, prolongation of pr interval and qrs complex, and non-specific changes in 25%. central nervous system involvement occurred in the second week with general symptoms (hea ...	1966	4288427
viral infections of toronto children during 1965: ii. measles encephalitis and other complications.	among 16 cases of measles encephalitis observed in toronto during 1964 and 1965, including six who were stuporous or comatose on admission and five who presented with convulsions, measles virus was isolated from csf of one patient, rising titres of measles antihemagglutinin were detected in another patient, and 14 showed high antibody titres in sera collected as early as two to five days after onset of the measles rash. increasing levels of measles antibody were detected in paired sera from thre ...	1966	4952371
[a laboratory of human relations at honey harbour].		1966	5177426
"skid row" syndrome: a medical profile of the chronic drunkenness offender.	from skid row, 227 chronic "drunks", inmates of the toronto jail, were studied to determine the physical features and illnesses of this group. complete physical examinations, liver function tests, routine hematology, urinalysis, chest radiographs were carried out and previous hospital records were obtained for each man. the data were analyzed by ibm computer and reported in terms of body systems. items that occurred in sufficient frequency were separated out and listed to compile a "skid row" sy ...	1966	5947765
powassan virus: persistence of virus activity during 1966.	powassan virus isolations were achieved from three of 60 pools of ixodes cookei ticks removed from 286 groundhogs (marmota monax) which were collected some 200 miles north of toronto between may 5 and september 5, 1966. virus yields per pool of one to 11 ticks ranged from 10(2.5) to 10(6.0) tcd(50) for primary swine kidney tissue cultures, and positive pools were collected on june 24, july 15 and august 10. powassan neutralizing antibodies were detected by mouse inoculation tests in 143 of 362 a ...	1967	6019677
[a laboratory of human relations].		1967	5182984
myxovirus dissemination by air.	myxoviruses including 150 strains of parainfluenza 1, 15 of parainfluenza 3 and five of influenza b virus were isolated from nasopharyngeal secretions obtained from 300 children less than 3 years of age who developed acute laryngotracheobronchitis during the preceding 48 hours. the patients were examined between october 1966 and january 1967, the peak monthly rate of virus isolation (67%) occurring during january. parainfluenza 1 virus was isolated from air obtained in the vicinity of one of 30 ...	1967	4290621
central nervous system involvement associated with unclassified echovirus types.		1968	5645182
occurrence of echovirus 33 infections in ontario.		1968	5690127
rabies today--man and animals.		1969	5812488
vitamin a reserves of canadians.	-a survey of vitamin a and carotene stores of canadians at five major centres across canada was completed. vitamin a and carotene analyses were performed on approximately 100 human liver specimens obtained at necropsy from each location.age influenced liver vitamin a stores. children between 1 and 10 years of age had the highest vitamin a stores while a trend toward lower liver stores occurred between 20 and 40 years of age. females had higher liver carotene stores than males but there was no su ...	1969	5364272
chromosome aberrations in 2159 consecutive newborn babies.		1969	4238063
psittacosis in hamilton: a case report and epidemiological study.	a case report of a patient severely ill with psittacosis is presented, together with an epidemiological study of his fellow workers. this study illustrates the contagiousness of the disease and indicates that it is probably more prevalent than clinical experience suggests. only three of the 83 persons studied who were exposed became ill enough to seek medical attention. it is important that both the physician and the public be made aware of this disease so that definitive treatment can be instit ...	1970	5410417
strontium-90 and infant mortality in canada.		1970	5474939
a possible new enterovirus serotype isolated in ontario.		1971	4109494
a new subtype of type a influenzavirus isolated from turkeys.	a new subtype of avian influenzavirus a was isolated in january 1967 from an epizootic in a turkey hatchery in ontario, canada. the disease was fatal in 65 of 2 500 hens involved. virus was isolated from lung and trachea tissue of three dead turkeys. sera from convalescent birds contained antibody against the viruses isolated from the outbreak but not against other known type a avian influenzaviruses, newcastle disease virus, myxovirus yucaipa, or mycoplasma gallisepticum.the strain designated a ...	1972	4541004
bovine tuberculosis in humans in ontario. the epidemiologic features of 31 active cases occurring between 1964 and 1970.		1972	4627829
at sunnybrook medical centre: the human side of rehabilitation.		1973	4781704
review of human renal transplantation at the toronto general hospital.		1973	4570266
listeria monocytogenes infections in canada.	between 1951 and january 1972 listeriosis was diagnosed bacteriologically in 101 canadian patients. this study adds 80 cases to the 21 reported from metropolitan toronto by sepp and roy in 1963. the laboratory centre for disease control, ottawa, collated epidemiological and clinical data. serotypes of listeria monocytogenes included 4b (53), 1 (15), 1b (6), 1a (2), 2 and 3. clinically, 54 patients had meningitis and 23 septicemia. the mortality rate was 30%.between 1954 and january 1972 listerio ...	1973	4198595
interference of influenza-specific iga antibodies present in throat washings with isolation of the virus.		1973	4201894
survey on the incidence of yersinia enterocolitica infection in canada.	data pertaining to 278 cultures of yersinia enterocolitica isolated in canada are summarized in this paper. of this amount, 256 were isolated from humans, whereas 22 were of nonhuman sources. the typing of these cultures is presented together with their geographical location. y. enterocolitica serotype o:3 biotype 4, phage type 9b, was practically the only serotype present in the province of quebec. this serotype o:3 was also predominant in ontario, followed by serotypes o:5,27 and o:6,30; other ...	1974	4472776
the strengths and weaknesses of university review committees to protect human rights.		1974	4844661
an immunoprecipitin study of the incidence of influenza a antibodies in animal sera in the ottawa area.	a survey of over 600 'normal' sera from 14 animal species by immunoprecipitin tests in cellulose acetate using viron antigens revealed a high incidence of precipitating activity against a broad range of influenza a virus strains, particularly a2hhong kong/1/68 and /pr8. however, serum treatments trypsin-heat-periodate, naio4, v. cholerae receptor-destroying enzyme (rde), or kaolin eliminated most precipitating activity, which suggests that it was due to "non-specific" inhibitors of influenze vir ...	1975	167931
personalized care assures patients' rights.		1975	238881
alan brown, the man.		1975	1098761
autopsy data and their total evaluation.	the role of the autopsy is discussed in the study of the etiology of the current major causes of death (cardiovascular and neoplastic diseases) in developed countries. evidence is accumulating for the importance of environmental factors in the etiology of these diseases. the study of regional differences in occurrence is described as a method of identifying specific factors. maps are shown of mortality rates for all causes of death in ontario counties for males aged 65-74 and 95+ during 1964-68. ...	1975	1109383
comparative study of ddt and its derivatives in human blood samples in norfolk county and holland marsh, ontario.		1975	1131452
distribution of organochlorine pesticides in an agricultural environment, holland marsh, ontario--1970-72.	analaysis of organochlorine pesticides in soil, fish, and human blood samples from holland marsh, ontario, indicates that although total ddt is present in detectable amounts, it does not constitute a hazard to human health and longevity. among soils tested, residues were highest in surface samples. ddt levels in human blood samples were similar to those in u.s. and british studies.	1975	1181548
the human hemoglobin variants in canada.	this report summarizes the results of a search for abnormal hemoglobin variants by use of a filter paper electrophoresis technique on 228,300 blood samples obtained from various parts of four canadian provinces. abnormal variants were found in 438 samples and were of 27 different varieties, including six new ones. in addition, the characteristics of beta-thalassemia were found in 147 samples. the types of variant found, and their geographical and ethnic origin are presented.	1975	1201625
human aural myiasis: a case in ontario, canada, and a partial review.		1976	1255358
sociocultural variation in sick role behavioural expectations.		1976	1265488
chromosome analysis on 930 consecutive newborn children using quinacrine fluorescent banding technique.	chromosome analysing using quinacrine fluorescence was performed on 930 consecutive newborn infants. the total incidence of major chromosome aberrations including numerical changes of the sex chromosomes, and structural changes of autosomes, was 0.54%. incidence of xyy (0.4%) and xxy (0.2%) were relatively higher as compared to other studies. about 0.75% of the newborn infants were found to have a variable bright fluorescent band located on the proximal area of the short arm (p11) rather than on ...	1976	60278
physician contributions to nonmedical science: davidson black, our peking man.		1976	793707
crowding and human reproduction.	studies of crowding in lower animals repeatedly demonstrate that compressed living conditions depress the ability of the species to reproduce. in a sample of 470 urban toronto women we examined the effect of neighborhood and household crowding on the probability of a pregnancy and on the probability that any given product of the pregnancy will not survive until one year of age. crowding did not influence fertility nor fetal and infant survival within the range of crowding found in this sample. ...	1976	958631
marfan syndrome with coronary artery lesions in a north american indian.	marfan syndrome has not been well documented in north american indians. a 19-year old ojibwa man had evidence of this syndrome -- specifically, tall stature, long, thin extremities (particularly, fingers and toes), increased urinary excretion of hydroxyproline, aortic aneurysm, aortic regurgitation and pathologic evidence of aortic rupture and alastic tissue fragmentation. intimal hyperplasia was present in the extramural coronary arteries, while the intramural arteries, usually thought to be in ...	1976	974953
fatal human infection with mesocercariae of the trematode alaria americana.	a fatal human infection with mesocercafiae of alaria americana is described. several thousand mesocercariae were estimated to be present in the peritoneal cavity, bronchial aspirate, brain, heart, kidney, liver, lungs, lymph nodes, pancreas, retroperitoneal adipose tissue, spinal cord, spleen, and stomach. nine days from the onset of symptoms death resulted from asphyxiation due to extensive pulmonary hemorrhage probably caused by immun-mediated mechanisms. circumstances suggest the victim proba ...	1976	1008125
the ombudsman in mental health: lakeshore's experience.		1976	1027535
inter vivos transplantation and the human tissue gift act, s.o. 1971 c. 83.		1976	11662668
organochlorine residues in human adipose tissue and milk from ontario residents, 1969-- 1974.		1977	849578
human tick infestations in ontario: findings at the toronto public health laboratory, 1967-1977.		1977	603862
the prevalence and epidemiology of toxoplasmosis in ontario.	the results of testing 7060 human serum specimens obtained in the province of ontario, canada, were analysed for the presence of antibodies to toxoplasma gondii. of these samples 38% were serologically positive at a titre of 1/16 or greater. the age-specific rates climbed from 2.7% in infants between 6 months and 1 year of age, to about 50% in individuals aged 25 years or over. variations in prevalence were noted between different areas within the province and evidence is put forward to show tha ...	1977	265346
antimicrobial susceptibility of salmonella isolates from the broiler chicken industry in ontario.	antibacterial drug resistance among 219 salmonella isolates recovered during 1974 from poultry and poultry environments at the various production stages of broiler chickens in three integrated ontario companies are recorded. all isolates were susceptible to ampicillin, trimethroprim-sulfamethoxazole complex, furazolidone, cephaloridine and amoxicillin. a relative increase in resistance to tetracycline and streptomycin with an accompanying decrease in resistance to triple sulfa compound was recor ...	1977	318909
antimicrobial resistance and resistance plasmids in salmonella from ontario, canada.	collections of 589 human and 204 animal strains of salmonella isolated in ontario during the summer of1974 were examined for susceptibility to 12 antimicrobial agents. many isolates were found to be resistant to both chloramphenicol (12.4% of the human and 38.2% of the animal sample) and ampicillin. the chloramphenicol resistance almost always occurred in strains which were also resistant to ampicillin and was usually due to a self-transmissible plasmid with a resistance pattern of cmkmsmtc (chl ...	1977	332297
electric kettles as a source of human lead exposure.	five hundred and seventy-four households in ottawa were surveyed to evaluate water boiled in electric kettles as a source of lead exposure. samples of boiled water exceeded the world health organization mandatory limit for drinking water (50 microgram/l) in 42.5% of the households. excessive lead concentrations were observed in 62.8% of water samples from kettles more than 5 years old. multiple regression analysis indicated that age, sex, and cigarette smoking habits, but not lead concentration ...	1978	646460
influenza in a nursing home.		1978	647540
human blood cholinesterase activity--holland marsh, ontario, 1976.		1978	667390
isolation of yersinia enterocolitica from surface and well waters in ontario.	yersinia enterocolitica was isolated from forty-three surface- and well-water samples and one municipal supply. in many cases these samples were negative for coliform bacteria. after incubation of membrane filters on m-endo agar les at 35 degrees c for total coliform analysis, filters were held an additional 24 h at room temperature. this method was more productive for isolation of waterborne types of y. enterocolitica than was cold enrichment in buffer alone or in combination with modified rapp ...	1978	709433
gonorrhea in homosexual men.	extragenital gonorrhea was seen in 65% of 54 cases of gonorrhea in 43 homosexual men attending a venereal diseases clinic between 1974 and 1977; in 21 cases the infection was extragenital only. this type of gonorrhea was often asymptomatic and was associated with a high rate of failure of initial treatment in 6 of the 50 cases in which the patient returned for follow-up assessment, and in 5 of the 6 the persistent infection was extragenital. syphillis was seen concomitantly or had previously occ ...	1978	709473
report of survey of courses in medical terminology, human biology, health and disease presently required or available in programs in health or hospital administration.		1978	10318396
the occurrence of candida albicans in lake ontario bathing beaches.	there are inherent weaknesses associated with currently used bacterial fecal pollution indicator systems. fecal pollution indicator data would be more meaningful if supplemented with information relating to the occurrence of pathogens in recreational water. through surveys of four bathing beaches on lake ontario, it was established that the opportunistically pathogenic yeast candida albicans occurs in near shore waters. the beaches surveyed could be differentiated on the basis of bacterial fecal ...	1979	120220
familial urinary tract anomalies: association with the major histocompatibility complex in man.	histocompatibility typing of a family with 15 members and a history of ureteropelvic junction stenosis and 4 families with 23 members and a history of vesicoureteral reflux revealed that these anomalies of the urinary tract may be hereditary and segregate with histocompatibility haplotype within a family. thus, a close linkage of childhood reflux and ureteral stenosis with that of the major histocompatibility complex of man is suggested. if confirmed by further family studies it will place the g ...	1979	423332
human facial temperatures in natural and laboratory cold.	asian, european, and american indian men were subjected to craniofacial cooling to determine relative ranking and temperature curves for various facial skin sites. moving and still air 0 degrees c to -35 degrees c in both laboratory and subarctic outdoor settings were used. the objective was to examine resistance to facial frostbite. facial temperatures stabilize well above freezing even under quite cold conditions and this conclusion is congruent with low incidences of facial frostbite. racial ...	1979	454321
canadian experience with yersinia enterocolitica (1966--1977).	data pertaining to 1,219 cultures of yersinia enterocolitica isolated in canada are summarized. of the 977 cultures isolated from humans, y. enterocolitica serotype 0:3, biotype 4, phage type ixb was the most predominant type in ontario, quebec and the four eastern provinces. in the western provinces the predominant strains were indol-positive, serotypes 0:8; 5,27 and 4,32. most of the 242 cultures of nonhuman origin, except those isolated from swine and a few isolated from wild animals, were in ...	1979	535372
dehler v. ottawa civic hospital et al. 5 sep 1979.		1979	11645420
[antigenic characterization of influenza a virus isolated from birds captured in ontario, quebec, and the maritime provinces during the 1977 season].	a total of 145 influenza a viruses were isolated from ducks, geese and passerine birds in ontario, québec and the maritimes in july-august 1977. antigenic characterization of these isolates included five hemagglutinin (hsw1, hav4, hav5, hav6, hav7) and five neuraminidase subtypes (n1, n2, neq1, neq2, nav1) in nine different combinations; one combination hav7 neq1 had not been previously reported. the majority of these viruses were hsw1 n1, antigenically related to influenza viruses in pigs and h ...	1980	7433721
approaches to immunization of infants and young children against gastroenteritis due to rotaviruses.	recent studies have shown that in developed countries rotaviruses are the single most important etiologic agents of acute gastroenteritis that requires hospitalization of infants and young children. although deaths from gastroenteritis are, in general, infrequent in the developed countries, an effective rotavirus vaccine would clearly be of benefit to reduce the heavy toll of morbidity from gastroenteritis due to rotavirus. in the developing countries the impact of diarrheal diseases is staggeri ...	1980	6251528
consent and the human tissue gift acts: a rationale for change.		1980	10309551
community based monitoring for spinal man.		1981	7284945
yersinia enterocolitica isolated from throats of swine in eastern and western canada.	examination of the throat flora from swine in ontario for yersinia enterocolitica found the incidence of serotype o:3 to vary from 20% from tonsils to 50% for throat swabs and 55% for tongues. in contrast, there were no isolations of serotype o:3 from throat swabs taken from swine in the western provinces of british columbia and alberta. this incidence of serotype o:3 in swine correlates well with the human incidence of the same serotype which is 81% for all human isolations of y. enterocolitica ...	1981	7332882
quantitative interlake comparison of thyroid pathology in great lakes coho (oncorhynchus kisutch) and chinook (oncorhynchus tschawytscha) salmon.	coho salmon (oncorhynchus kisutch) and chinook salmon (oncorhynchus tshawytscha) from lakes ontario, michigan, erie, or huron were found to suffer epizootics of thyroid hyperplasia and goiters which appeared to have an environmental etiology. there were 13-fold differences in goiter prevalence within the great lakes, and the differences in goiter frequency were correlated with the degree of thyroid hyperplasia. a means of assessing the degree of thyroid hyperplasia (thyroid index) is described, ...	1981	7237420
ethical and psychiatric aspects of torture: a canadian study.	in the last two decades widespread use of torture by totalitarian governments has been reported in over 60 countries. this situation concerns physicians who are sometimes called upon to see the victims. this paper reports the psychiatric findings in a group of 41 latin american refugees who arrived in canada from 1977 to 1979 and alleged to have been subjected to political persecution and torture under the military rulers of their own countries. most of them, young educated men, were apprehended ...	1982	7066853
design for the human factor.		1982	10254514
representing handicapped persons' claims under the ontario human rights code and the canadian charter of rights and freedoms.		1983	10317404
a field trial, of preshipment vaccination, with intranasal infectious bovine rhinotracheitis-parainfluenza-3 vaccines.	a total of 849 calves, 278 controls, 335 vaccinated intranasally with ibr-pi3/ts and 236 vaccinated intranasally with ibr-pi3/ptc were studied in a field trial of preimmunization. all calves were vaccinated in saskatchewan at least three weeks prior to shipment to feedlots. four hundred and twenty six calves were not sold within eight weeks of vaccination; however, seven of these died within four weeks of vaccination. treatment rates varied from 1.0% to 5.2%. there was no significant effect of v ...	1983	6315194
larry grossman - man for the future.		1983	6550440
human resource planning at toronto's baycrest centre.		1983	6680366
variability in caffeine metabolism.	urinary metabolites excreted after oral caffeine were quantified in a healthy sample (n = 68) from the toronto population by hplc analyses. the profile of metabolites, assessed by examining particular metabolite ratios, was found to differ widely among subjects. ratios denoting cytochrome p-450-dependent activities were shown to be interethnically variable between oriental and caucasian groups, whereas those indicative of xanthine oxidase activity exhibited neither significant interindividual va ...	1983	6687705
human rights versus occupational medicine.	this paper examines the conflict between the medical monitoring of workers and human rights. a lead regulation in force in ontario, despite its absolute conflict with an important guideline established by the canadian human rights commission, is presented as an example of the erosion of human rights by certain legislated activities in occupational medicine. the question of whether the benefits of occupational medical activities outweigh the disadvantages attendant upon the erosion of human right ...	1983	6853002
epidemiologic basis for photochemical oxidant standard.	the problem of photochemical oxidant pollution, 98% of which is ozone, is addressed. ozone itself is not the cause of all adverse effects (e.g., peroxyacetyl nitrites cause eye irritation). the typical sequence in the development of oxidant pollution is an initial increase in nitrous oxide, followed by nitrogen dioxide, followed by ozone. these pollutants can be carried long distances and may have long range effects. ozone is considered by far the most irritant gas to humans, with effects seen e ...	1983	6653514
silver staining of dna restriction fragments for the rapid identification of adenovirus isolates: application during nosocomial outbreaks.	the ultrasensitive photochemical silver stain for nucleic acids, described by beidler et al. (1982), has been applied to the detection of adenovirus restriction fragments as a relatively rapid technique for the identification of virus isolates. in this study, restriction enzyme cleavage analysis was used to characterize adenovirus isolates from what appeared to be two nosocomial outbreaks. the first outbreak was thus shown to include two clusters of patients, and involved two serotypes ad7c and ...	1984	6210299
erythema infectiosum: an epidemic with a probable posterythema phase.	an outbreak of erythema infectiosum occurred in an ontario school in the spring of 1983. this benign disease ran a 19-day course in the index case and appeared in most of the child's grade 1 classmates. a few adults were also affected. in eight children flu-like symptoms persisted or occurred suddenly and lasted for several days after the rash had vanished. a plan of management that involves communication with parents, teachers and the public health service is outlined for the general practition ...	1984	6697272
a comparison of organochlorine residues in human adipose tissue autopsy samples from two ontario municipalities.	human adipose tissue samples obtained during autopsies in a canadian great lakes community, kingston, ontario, and a second community, ottawa, ontario, were analyzed for organochlorine pesticides, polychlorobiphenyls, chlorobenzenes, and chlorophenols. significantly different levels of dichlorodiphenyl -dichloroethane, mirex, hexachlorobenzene, and 2,3,4,6-tetrachlorophenol were found in kingston adipose tissues compared to ottawa tissues. residue levels of oxychlordane , mirex, and polychlorina ...	1984	6716511
characterization of strains of corynebacterium bovis.	the biochemical and morphological characteristics of 104 strains of corynebacterium bovis isolated from bovine milk samples and the c. bovis reference strain were found to be uniform. valuable criteria for identification were presence of catalase and oxidase, production of acid from glucose and fructose and a requirement for enriched basal media. six strains of human and three strains of bovine origin were found to be inconsistent with the reference strain.	1984	6722650
inactivated poliovirus vaccine and test development at connaught laboratories ltd.	trivalent inactivated poliovirus vaccine (ipv) (mk) was made, purified, and inactivated according to the amended rijks instituut (the netherlands) protocol from primary monkey kidney tissue grown on microcarrier cultures. losses of the type 2 component due to adsorption to the glass ampule occurred with the purified vaccine preparation. this problem was solved by changing the diluent, and the vaccine was submitted for evaluation in clinical trials at johns hopkins (baltimore, md.). phase 2 of th ...	1984	6330837
listeria monocytogenes infections in canada.	since its first isolation by murray in 1926 listeria monocytogenes has become recognized as a significant pathogen occurring worldwide and involving a wide range of wild and domestic animals including man. the first confirmed human listeriosis case in canada was published by stoot in 1951. a later survey based on records maintained at the laboratory centre for disease control, ottawa showed 101 cases detected over a 21 year period in nine provinces. the overall mortality was 30%. the most freque ...	1984	6442654
influenza vaccination in the elderly: 2. the economics of sending reminder letters.	reminder letters and follow-up telephone calls were used to increase influenza vaccination acceptance by 273 well elderly registered at an urban community health centre. the net effect of the reminder letters was to increase overall coverage to 43%, from 17% in the previous year. follow-up telephone calls to patients who had not responded to the letters increased coverage to only 55%. calculation of costs per additional vaccination given revealed that the use of reminder letters alone was much m ...	1985	3971268
inter-laboratory quality control of estrogen and progesterone receptor assays in breast cancer tissue using lyophilised cytosols.	in 1981 a quality control (qc) program for estrogen and progesterone receptor assays was organized among six laboratories in ontario, canada. twenty-three vials of lyophilised cytosol prepared from human breast tumor tissues were analysed by each laboratory over a two-year period. samples of each batch of qc material were analysed at least twice: either in the same batch or on separate occasions. the present study demonstrates the stability of the qc material, defines the relative accuracy of th ...	1985	3986988
molecular analysis confirms food source and simultaneous involvement of two distinct but related subgroups of salmonella typhimurium bacteriophage type 10 in major interprovincial salmonella outbreak.	more than 2,000 confirmed cases of food poisoning occurred in the four atlantic provinces of canada and in ontario during the second and third quarters of 1984. salmonella typhimurium phage type 10 was identified as the etiologic agent, and cheddar cheese was implicated as the source of infection. strains isolated from infected humans and from cheese were indistinguishable by biotyping, antibiotic resistance typing, and phage typing. plasmid analysis confirmed cheese as the source of infection a ...	1985	3911899
outbreak of diarrhea in a day nursery in ontario.		1985	2986812
community occupational therapists and volunteers: a survey of utilization and satisfaction.	current estimates lead us to believe that approximately 16% of the population works in some capacity on a volunteer basis. in spite of the size of this valuable human resource, occupational therapists often remark that they are unable to find suitable volunteers to assist with patient-related activities. the present study is an attempt to explore this topic, looking specifically at how community occupational therapists use volunteers, and how satisfied they are with the services provided. a desc ...	1985	10271291
human-centred design is a future facility prototype.		1986	10280231
social inequality and healthy public policy.	for decades, health education programmes have been based on the assumption that individual behaviours (for example smoking, drug use, eating patterns) are the major risk-factors in contemporary illness. this assumption often led to interventions that subtly "blamed the victim" for his or her ill-health. in recent years the broader social conceptualization of health and illness has directed many health educators' attention towards socio-economic and environmental factors which condition and const ...	1986	10286866
studies on fastidious adenoviruses in ontario: a distinct strain associated with gastroenteritis.	from 100 cases of gastroenteritis among children caused by adenovirus infection in ontario, 33 virus isolates were divided into three categories according to their biological behavior in tissue cultures. so far, the results of neutralization tests, structural protein analysis, and dna restriction patterns showed that the virus of category 1 was similar to adenovirus type 40. however, the adenovirus of category 2 was a distinct adenovirus which shared some similarities with adenovirus type 5. vir ...	1986	3009537
a population study of the jugular foramen bridging of the human cranium.	the author previously proposed a simple standard for diagnosing the jugular foramen bridging in man. the incidence of this bridging trait was investigated according to that standard in nine cranial series of east indians, micronesians, japanese, ainu, mongols, aleuts, alaskan eskimos, canadian eskimos, and ontario iroquois. no sex difference in incidence of the trait was recognized. side difference in trait incidence was also slight but was statistically significant in the combined series of all ...	1986	3946593
levels of triaryl/alkyl phosphates in human adipose tissue from eastern ontario.		1986	3719141
giardia lamblia in children in day-care centres in southern ontario, canada, and susceptibility of animals to g. lamblia.	in 1982, giardia lamblia cysts were found in the faeces of eight of 97 children (two to five years old) in day-care centres in guelph, ontario, canada. none of the infected children showed any of the classical signs of giardiasis. the survey was repeated in 1983 in the kitchner-waterloo area, ontario. in this survey nine of 147 children were infected with g. lamblia. experimentally established giardia-free colonies of mice, hamsters, rats, cats (adults and kittens) and dogs (adults and puppies) ...	1986	3726998
rate of campylobacter spp. isolation in three regions of ontario, canada, from 1978 to 1985.	isolation rates of campylobacter spp. were analyzed for an 8-year period, 1978 through 1985. three laboratories of the ontario ministry of health examined 146,842 human feces samples for bacterial pathogens, including campylobacter jejuni and campylobacter coli. campylobacter spp. were isolated from 5,580 specimens (3.8%), with monthly isolation rates ranging from 1.1 to 7.4%. the data showed a seasonal distribution of isolations, with peaks during the summer months (june to september). most inf ...	1986	3771774
htlv-iii infection in canada in 1985.	more than 25 000 serum specimens have been tested for antibody to human t-lymphotropic virus type iii (htlv-iii) at the laboratory centre for disease control, ottawa, since august 1984. in 1985 the prevalence rates of antibody positivity among selected risk groups were as follows: patients with kaposi's sarcoma, 77%; patients with acquired immune deficiency syndrome (aids) or aids-related complex (arc), 66%; patients with hemophilia, 65%; symptomatic homosexual men, 48%; cohabitants of patients ...	1986	3461870
genetic polymorphism of mephenytoin metabolism.		1986	3523505
evaluation of a confidential method of excluding blood donors exposed to human immunodeficiency virus.	a confidential self-administered questionnaire was given to all donors prior to blood donation (n = 95,917). the questionnaire describes acquired immunodeficiency syndrome (aids) high-risk groups and requires the donor to designate his blood for either laboratory purposes or for transfusion. six-hundred and twenty-seven people (0.65%; 78% men) designated their blood for laboratory purposes. in addition to routine enzyme-linked immunoassay (eia) screening for human immunodeficiency virus (hiv) an ...	1986	3535180