Publications

helicobacter pylori infection rates in relation to age and social class in a population of welsh men.	the seroprevalence of igg antibodies to helicobacter pylori was determined using a standard enzyme linked immunosorbent assay in a population of 749 randomly selected men, aged 30-75 years, from caerphilly, south wales. the overall prevalence of h pylori was 56.9%, increasing sharply in middle age from 29.8% in those aged 30-34 to over 59% in those aged 45 or older (p less than 0.0001). age standardised seroprevalence rates were lowest in combined social class categories i and ii (49.2%), interm ...	1991	1991634
association between infection with helicobacter pylori and risk of gastric cancer: evidence from a prospective investigation.	to investigate the association between gastric cancer and prior infection with helicobacter pylori.	1991	2059685
helicobacter pylori infection rates in relation to age and social class in a population of welsh men.		1992	1452089
social and geographical risk factors in helicobacter pylori infection.	a correlation between childhood crowding and the later development of gastric cancer has been demonstrated by barker and colleagues, who proposed that the relationship was the consequence of infection by an organism such as helicobacter pylori. in order to test this hypothesis the presence of igg antibodies to h. pylori in sera from blood donors in north wales has been investigated. during donation sessions, donors answered questions relating to social conditions and domicile in childhood (at ag ...	1993	8348934
why is mortality higher in poorer areas and in more northern areas of england and wales?	to identify and quantify the factors responsible for the differences in mortality between affluent and deprived areas, the north and the south, and urban and rural areas in england and wales.	1998	9764254
ischaemic heart disease and cag a strains of helicobacter pylori in the caerphilly heart disease study.	to look for the presence of the more virulent strains of helicobacter pylori (h pylori) in men who developed ischaemic heart disease over a 10 year period and in controls.	2001	11602541
recent trends in admissions and mortality due to peptic ulcer in england: increasing frequency of haemorrhage among older subjects.	although overall admission rates for peptic ulcer in england declined from the 1950s up until the mid 1980s, perforations among older women increased, possibly due to increasing use of non-steroidal anti-inflammatory drugs (nsaid). since then, proton pump inhibitors, antibiotic treatment for helicobacter pylori, low dose aspirin, and selective serotonin reuptake inhibitors (ssri) have been introduced aims: to determine time trends for hospital admissions for peptic ulcer from 1989 to 1999 (engla ...	2002	11889062
the burden of helicobacter pylori infection in england and wales.	the prevalence of active infection with helicobacter pylori in the general population of england and wales was estimated using high reactivity for specific igg in serum elisa as a marker. a total of 10,118 anonymized residues of serum samples collected in 1986 and 1996 from persons aged 1-84 years were used. estimated prevalence of active infection varied by region and was highest in london. prevalence was related to decade of birth and increased from 4-3% in those born during the 1980s to 30% i ...	2002	12113485
a simulation to evaluate screening for helicobacter pylori infection in the prevention of peptic ulcers and gastric cancers.	a discrete event simulation model has evaluated a screening programme for helicobacter pylori infection (h. pylori) in which individuals under the age of 50 years would be screened once. eradication of h. pylori would reduce the peptic ulcer risk immediately and the gastric cancer risk after a fixed delay. the data were derived from published databases and peer reviewed papers. the simulation model, using variance reduction techniques, predicted that a screening programme would reduce morbidity ...	2002	12437272
the cost-effectiveness of screening for helicobacter pylori to reduce mortality and morbidity from gastric cancer and peptic ulcer disease: a discrete-event simulation model.		2003	12709294
cost-effectiveness of population screening for helicobacter pylori in preventing gastric cancer and peptic ulcer disease, using simulation.	to evaluate the cost-effectiveness of population screening for helicobacter pylori in preventing gastric cancer and peptic ulcer disease in england and wales.	2003	14561268
helicobacter pylori antibiotic resistance patterns and genotypes in adult dyspeptic patients from a regional population in north wales.	surveillance data on helicobacter pylori antibiotic susceptibilities in wales are limited, despite resistance being a key factor in treatment failure. a single-centre survey was undertaken over 3 years to determine local antibiotic resistance rates on isolates from dyspeptic patients in bangor, gwynedd (north wales).	2004	15243025
managing dyspepsia without alarm signs in primary care: new national guidance for england and wales.	to report new recommendations for the primary care management of dyspepsia without alarm signs in england and wales.	2005	15854176
real-time pcr detection and frequency of 16s rdna mutations associated with resistance and reduced susceptibility to tetracycline in helicobacter pylori from england and wales.	to investigate the occurrence of 16s rdna mutations associated with resistance or reduced susceptibility to tetracycline in helicobacter pylori isolated in england and wales, and to develop a real-time pcr assay to detect these dna polymorphisms from culture and gastric biopsies.	2005	15958499
causes underlying the birth-cohort phenomenon of peptic ulcer: analysis of mortality data 1911-2000, england and wales.	since humans have been infected with helicobacter pylori for millennia, it has remained an enigma why the occurrence of gastric and duodenal ulcer rose suddenly during 19th century. the study aim is to present a mathematical model of h. pylori epidemiology that explains the peculiar long-term trends of ulcer disease.	2006	16709617
surveillance of primary antibiotic resistance of helicobacter pylori at centres in england and wales over a six-year period (2000-2005).	antibiotic resistance is a key factor in the failure of helicobacter pylori eradication therapy, yet few sentinel schemes exist to monitor trends in resistance at local, national or international levels. this study aimed, over a six-year period, to monitor resistance levels of h. pylori in england and wales to the four antibiotics used in its treatment. a total of 1,310 isolates from gwynedd in north wales and from mid-essex in south-east england were collected from 2000 to 2005 and tested for s ...	2007	17991408