Publications

the complete sequence of a human astrovirus.	we have determined the complete genomic sequence of human astrovirus serotype 1 isolated in newcastle upon tyne. the genome is 6813 nucleotides long and contains three sequential open reading frames (orfs). the two closest to the 5' end are linked by a ribosomal frameshifting motif and contain sequence motifs indicative of non-structural virus proteins: serine protease and rna-dependent rna polymerase. a nuclear addressing sequence is also located here. the 3' orf encodes the virion structural p ...	1994	8021608
seroprevalence of astrovirus types 1 and 6 in london, determined using recombinant virus antigen.	we have developed a microimmunofluorescence test (if) which uses cells infected with a recombinant baculovirus which expresses the capsid proteins of astrovirus types 1 or 6. the if test was sensitive and specific and the results for human astrovirus type 1 (hast-1) were comparable to those obtained by immune electronmicroscopy and radioimmunoassay. application of the test to a panel of 273 sera collected from patients and staff at two childrens hospitals in london showed that over 50% of the po ...	1996	8760964