Publications

large-scale use of sabin type 2 attenuated poliovirus vaccine in singapore during a type 1 poliomyelitis epidemic.		1959	13662613
prevention of poliomyelitis in singapore by live vaccine.		1964	14113821
the poliomyelitis immunization programme in singapore.		1965	14341533
a recent epidemic of coxsackie virus type a24 acute haemorrhagic conjunctivitis in singapore.	a recent epidemic of acute conjunctivitis in singapore showed again the importance of coxsackie virus type a24 variant as a causative agent of acute haemorrhagic conjunctivitis (ahc). although the ocular manifestations appeared similar to those described for the 1970 and 1975 outbreaks, a markedly higher rate of respiratory involvements was noted. not observed in previous epidemics were herpes-like vesicles in the conjunctiva and eyelids of one patient and vesicles in the buccal mucosa and lips ...	1986	3024697
immune status of the population to poliovirus infection in singapore.	a seroepidemiological survey conducted after two decades of mass immunization against poliomyelitis in singapore showed a high level of herd immunity in the population to all three types of human poliovirus. neutralizing antibodies to poliovirus 1, 2 and 3 were detected in 93.9-96.7% of the population between 6 months and over 40 years old. adults above 30 years of age had a relatively high level of susceptibility to poliovirus infection, with 10.2-12% in the over-30-year age group possessing no ...	1987	3034442
review of the poliomyelitis immunization campaign and syndromes associated with poliovirus in singapore.		1987	2836655
poliovirus neutralising antibody in infants and cord blood.	singapore participated in the who epi protocol for rapid assessment of serological response to three doses of standard oral poliovirus vaccine. the 100% seropositive finding of thirty infants below one year old is no proof of seroconversion rate to the trivalent oral poliovirus vaccine (topv) administered. investigation of 100 cord blood samples showed that passively transferred maternal poliovirus neutralising antibody cannot be relied upon for protection of infants against poliomyelitis. this ...	1993	8396883
evidence for recombination in natural populations of dengue virus type 1 based on the analysis of complete genome sequences.	recombination events are known to occur in non-segmented rna viruses like polioviruses or alphaviruses. analysis of the subgenomic sequences of dengue virus type 1 (denv-1) structural genes has recently allowed the identification of possible recombination breakpoints. because denv is a major human pathogen, this discovery might have important implications for virus pathogenicity, vaccine safety and efficiency, or diagnosis and, therefore, requires clear confirmation. we report the complete seque ...	2001	11369871
wild poliovirus isolation from a nigerian child with acute flaccid paralysis seeking medical care in singapore.		2006	16858907
molecular identification of coxsackievirus a24 variant, isolated from an outbreak of acute hemorrhagic conjunctivitis in singapore in 2005.	an outbreak of acute hemorrhagic conjunctivitis (ahc) was reported in singapore military camps in the year 2005. a total of 103 conjunctival swab specimens were collected from military personnel diagnosed clinically with ahc. pcr testing on these conjunctival specimens revealed the presence of an enterovirus, and this was confirmed by virus isolation. molecular typing using a partial vp1 gene confirmed a variant of coxsackievirus a24 (ca24v) as the most likely etiological agent for the outbreak. ...	2007	17680326
safety and reactogenicity of dtpa-hbv-ipv/hib and dtpa-ipv/i-hib vaccines in a post-marketing surveillance setting.	combination vaccines have been shown to improve the timeliness of vaccination and vaccine coverage. safety and reactogenicity of combined diphtheria-tetanus-acellular pertussis-inactivated poliovirus and haemophilus influenzae type b vaccine (dtpa-ipv/hib, infanrix ipv+hib, glaxosmithkline biologicals) was assessed in two clinical studies. in study a, 2,590 subjects received dtpa-ipv/hib at 3, 4 and 5 months of age with a booster at 18 months. in study b, 702 subjects received the same schedule ...	2011	21323176
certification of poliomyelitis eradication in singapore and the challenges ahead.	this study reviewed the epidemiological trends of poliomyelitis from 1946 to 2010, and the impact of the national immunisation programme in raising the population herd immunity against poliovirus. we also traced the efforts singapore has made to achieve certification of poliomyelitis eradication by the world health organisation.	2012	23235729
comparative seroepidemiology of pertussis, diphtheria and poliovirus antibodies in singapore: waning pertussis immunity in a highly immunized population and the need for adolescent booster doses.	we assessed the seroepidemiology of pertussis, diphtheria and poliovirus antibodies in a cohort of highly immunized children, together with the burden of these diseases in singapore.	2012	22475863