Publications

group c rotavirus infections in patients with diarrhea in thailand, nepal, and england.	atypical rotavirus obtained from fecal specimens of six patients with diarrhea from thailand, nepal, and england were characterized by using polyacrylamide gel electrophoresis and immune electron microscopy. the electropherotypes were characteristic of the porcine reference group c rotavirus strain but demonstrated considerable strain-to-strain variation. human convalescent group c sera had a high titer (1:320) when tested against the human isolates and a low titer (1:40) when tested against a p ...	1989	2547880
group c rotavirus associated with fatal enteritis in a family outbreak.	a family outbreak of gastroenteritis involving three adults and three children is described in which diarrhoea and vomiting were the main clinical features. one infant died in whom no pathogens could be detected in either small or large intestinal postmortem samples. stool samples from two symptomatic siblings contained rotaviruses as demonstrated by electron microscopy. both of these faecal samples were negative when assayed in a group a specific rotavirus enzyme-linked immunosorbent assay (eli ...	1990	2341836
epidemiological survey of human rotavirus serotypes and electropherotypes in young children admitted to two children's hospitals in northeast london from 1984 to 1990.	a retrospective and prospective survey was carried out to determine the relative frequency of rotavirus serotypes infecting children with diarrhea or vomiting or both who were admitted to the hospitals for sick children in london during a 6-year period from 1984 to 1990. the results were compared with data for the same period from a study in birmingham, united kingdom. the serotype of rotaviruses infecting 1,019 children was ascertained by enzyme immunoassay with vp7-specific monoclonal antibodi ...	1991	1658035
the correct sequence of the porcine group c/cowden rotavirus major inner capsid protein shows close homology with human isolates from brazil and the u.k.	amino acid sequence alignments between the human group c/bristol and the published porcine group c/cowden vp6 proteins have revealed a region of extreme sequence divergence. we have been unable to confirm the nucleotide sequence of the cowden vp6 gene corresponding to this region of divergence. direct sequencing of a pcr-amplified cdna pool has revealed a frame shift, and three nucleotide changes, within the published sequence of the porcine (cowden) vp6 gene. the corrected sequence of the porci ...	1992	1326817
sequence conservation of the major outer capsid glycoprotein of human group c rotaviruses.	several outbreaks of group c rotavirus infection have occurred in the united kingdom, in one instance infection was associated with the death of a 4-month-old infant in the bristol area. the origin of human group c rotavirus is unknown although there has been some speculation that porcine species may be a possible source of human infection. direct reverse transcription-polymerase chain reaction sequencing of vp7 genes from two uk outbreaks (bristol and preston) and sequence analysis from a spora ...	1994	7852957
enzyme-linked immunosorbent assay based on recombinant human group c rotavirus inner capsid protein (vp6) to detect human group c rotaviruses in fecal samples.	a recent study showed that 43% of a population in the united kingdom were seropositive for group c rotavirus. the higher than expected incidence may be due to limited diagnosis of acute human group c rotavirus infections because no routine test is available. human group c rotavirus infections are routinely diagnosed by electron microscopy (em) and a negative group a rotavirus enzyme-linked immunosorbent assay (elisa) result. an antigen-detection elisa was developed with hyperimmune antibodies ra ...	1998	9774561
seroepidemiology of group c rotavirus infection in england and wales.	a total of 3199 serum samples collected in 1993--1994 from two population cohorts from england and wales were tested for the prevalence of igg antibodies specifically directed against group c rotavirus vp6. seroprevalence was 39% (95% confidence intervals: 37.0-40.4%). seroprevalence was highest (46.0%) in the oldest age group (61-70 years of age). infection with group c rotaviruses occurred at an earlier age and with higher incidence in rural than in urban populations. these results may suggest ...	2004	15330133