Publications

dengue epidemic--peru, 1990.	from march to july 1990, an epidemic of classical dengue caused by dengue types 1 and 4 (den-1 and den-4) occurred in iquitos and the surrounding area of the department of loreto in the amazon region of peru (figure 1). a smaller outbreak was reported in tarapoto in the neighboring department of san martin. although cases were reported in peru during 1953-1955 and in 1958 (1), the epidemic in 1990 was the first laboratory confirmation of indigenous transmission of dengue in peru. this report sum ...	1991	1899900
the epidemiology of dengue virus infection among urban, jungle, and rural populations in the amazon region of peru.	the first confirmed outbreak of dengue fever in peru occurred during 1990 in iquitos, a city of approximately 300,000 residents in the amazon region. because of the apparent establishment of endemic transmission of this mosquito-borne viral disease following the outbreak, epidemiologic studies were initiated in 1992. blood specimens and data on demographic, environmental, and medical history factors were collected from volunteers in an urban sector of iquitos, in a rural area on the outskirts of ...	1996	8916809
failure of secondary infection with american genotype dengue 2 to cause dengue haemorrhagic fever.	population-based epidemiological studies have shown that infection with dengue type 2 (den-2) virus in individuals previously infected with a different serotype of the virus is a major risk factor for dengue haemorrhagic fever and dengue shock syndrome. however, the western hemisphere was spared epidemics of these two syndromes, until the introduction of a southeast asian den-2 genotype. possibly american den-2 genotype strains lacked properties necessary to cause severe disease. we report on a ...	1999	10543670
epidemiological and ecological characteristics of past dengue virus infection in santa clara, peru.	to determine risk factors associated with dengue (den) virus infection among residents of santa clara, peru, a rural amazonian village near iquitos, a cross-sectional serological, epidemiological and environmental survey was conducted. demographic, social and behavioural information was obtained by standardized questionnaire from 1225 santa clara residents (61.3%) aged 5 years or older. additional data were obtained on the environmental variables and immature mosquito species and abundance surro ...	2001	11299038
effect of dengue-1 antibodies on american dengue-2 viral infection and dengue haemorrhagic fever.	in iquitos, peru, no cases of dengue haemorrhagic fever have been recorded in individuals infected with dengue-1 virus followed by american genotype dengue-2 (american dengue-2) virus. we assayed serum samples collected in iquitos that tested positive for antibodies of monotype dengue-1 and monotype dengue-2 using a plaque reduction neutralisation test to determine their ability to neutralise the infectivity of two dengue-1 viruses, two american dengue-2 viruses, and two asian dengue-2 viruses. ...	2002	12147378
first documented outbreak of dengue in the peruvian amazon region.	this article describes a classical dengue outbreak caused by dengue serotypes 1 and 4 that occurred from march to july 1990 in the city of iquitos and surrounding areas of loreto department in the peruvian amazon. epidemiologic data indicate that more than 150,000 persons may have been affected in iquitos alone. another dengue outbreak occurred in tarapoto, a city in the neighboring department of san martín. laboratory data indicate that the same dengue serotypes were involved in both outbreaks. ...	2006	1393192
usefulness of commercially available gps data-loggers for tracking human movement and exposure to dengue virus.	our understanding of the effects of human movement on dengue virus spread remains limited in part due to the lack of precise tools to monitor the time-dependent location of individuals. we determined the utility of a new, commercially available, gps data-logger for long-term tracking of human movements in iquitos, peru. we conducted a series of evaluations focused on gps device attributes key to reliable use and accuracy. gps observations from two participants were later compared with semi-struc ...	2009	19948034
assessing and maximizing the acceptability of global positioning system device use for studying the role of human movement in dengue virus transmission in iquitos, peru.	as use of global positioning system (gps) technology to study disease transmission increases, it is important to assess possible barriers to its use from the perspective of potential study participants. fifteen focus group discussions stratified by sex, age, and motherhood status were conducted in 2008 in iquitos, peru. all participants said they would accept using a gps unit for study purposes for 2-4 weeks. participants' main concerns included caring properly for the unit, whether the unit wou ...	2010	20348526
epidemiology of dengue virus in iquitos, peru 1999 to 2005: interepidemic and epidemic patterns of transmission.	comprehensive, longitudinal field studies that monitor both disease and vector populations for dengue viruses are urgently needed as a pre-requisite for developing locally adaptable prevention programs or to appropriately test and license new vaccines.	2010	20454609
[circulation of a different lineage of dengue virus serotype 2 american / asian genotype in the peruvian amazon, 2010.]	our objective was to determine the genotype of the dengue virus type 2 (denv-2) that circulated in the amazon region of peru between november 2010 and january 2011. we analyzed eight samples collected during dengue surveillance activities in the cities of iquitos, yurimaguas, trujillo, tarapoto and lima between november 2010 and january 2011 that were sent to insitituto nacional de salud. the viruses were isolated in c6/36 ht cell line. viral rna was extracted and the serotype (rt - pcr multiple ...	2011	21537772
[impact of the dengue epidemic due to a new lineage of denv-2 american/ asian genotype in the health services demand in hospital "cesar garayar garcia", iquitos.]		2011	21537788
lineage ii of southeast asian/american denv-2 is associated with a severe dengue outbreak in the peruvian amazon.	during 2010 and 2011, the loreto region of peru experienced a dengue outbreak of unprecedented magnitude and severity for the region. this outbreak coincided with the reappearance of dengue virus-2 (denv-2) in loreto after almost 8 years. whole-genome sequence indicated that denv-2 from the outbreak belonged to lineage ii of the southeast asian/american genotype and was most closely related to viruses circulating in brazil during 2007 and 2008, whereas denv-2 previously circulating in loreto gro ...	2014	25002298