Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| neutralizing activity in human sera against the leukocyte-transforming agent. | 1973 | 4352332 | |
| antibodies to herpes group viruses in patients with nasopharyngeal and other head and neck cancers. | 1974 | 4366990 | |
| nasopharyngeal carcinoma: present status of knowledge. | 1974 | 4367157 | |
| epidemiology of cytomegalovirus infection after transplantation and immunosuppression. | viral infections and clinical complications were studied during hemodialysis and after renal transplantation. active cytomegalovirus infection developed in 96% of patients after renal transplantation; reactivation of herpes simplex, varicella-zoster, and epstein-barr viruses was found in 35%, 24%, and 0% of patients, respectively. cytomegalovirus viremia developed in 42% of patients an average of two months after renal transplantation, lasted 1.75 (+/- 1.5) months (except in one patient with chr ... | 1975 | 171315 |
| epidemiologic study of a leukocyte-transforming agent in a general population. | studies by others have demonstrated a leukocyte-transforming agent(s) (lta) in the oropharyngeal secretions of a significant number of individuals with epstein-barr virus-associated infectious mononucleosis, cancer, and, to a lesser extent, an outpatient population. this present study determines by systematic sampling the prevalence of lta in 27 families of a semirural community. throat swab inoculums from three of 54 adults and none of 44 children induced transformation of umbilical cord lympho ... | 1975 | 173738 |
| primary epstein-barr virus infections in children. | during a serioepidemiologic survey of a community, 13 (6.2%) of 209 children were found to be experiencing a current or recent primary epstein-barr virus (ebv) infection. the sera contained elevated antibody titers to viral capsid antigen of ebv, antibodies to early antigen (ea) of ebv, and specific igm. the frequency of primary infections was highest in the first decade of life. the primary ebv infections were usually asymptomatic. the antibody to ea was directed predominantly to the r componen ... | 1977 | 190581 |
| selected observations on the epidemiology of pharyngeal cancers. | the epidemiology of nasopharyngeal cancer (npc) has been compared with that of other pharyngeal cancers in los angeles county. epstein-barr virus (ebv) antibody titers were elevated in caucasians with pharyngeal squamous cell carcinomas regardless of subsite. as expected, an excess of npc cases was found among chinese. the role of various etiologic factors in npc including ebv, inhaled carcinogens, and salted fish was discussed. | 1977 | 206840 |
| differences in ebv antibody titres of patients with nasopharyngeal carcinoma originating from high, intermediate and low incidence areas. | in order to assess the differences in serological reactivities of npc patients from high, intermediate and low incidence areas, 288 npc sera from hong kong, singapore, tunis, east africa, paris and los angeles, together with sera from patients with ear, nose and throat tumours other than npc and with those from normal individuals from the same areas, were tested 'blind' with the same batches of antigen. important differences (up to 3-fold) in the gmts of antibodies directed against vca, ea and e ... | 1978 | 215529 |
| tonsillectomy and infectious mononucleosis. | tonsillar tissue may be the primary site of infection with epstein-barr virus (ebv), the etiologic agent of classical infectious mononucleosis (im). therefore, a retrospective study of the association between tonsillectomy and im was performed in a college student population. in the first part of the study, tonsillectomy rates were compared between 164 im-positive students and 164 student controls who attended ucla in 1972-1975. although it was determined that the development of im during colleg ... | 1978 | 203187 |
| incidence of infectious mononucleosis at the universities of california and hawaii. | the observed rates of heterophil-positive infectious mononucleosis at the university of california at davis and the university of hawaii at manoa were 1,212 and 37 per 100,000 students per academic year, respectively. the data collected suggest that the extraordinarily low incidence at the university of hawaii may be due to the following factors: (1) underutilization of the student health service by students with infectious mononucleosis; (2) low proportion of epstein-barr virus-seronegative stu ... | 1979 | 229170 |
| outbreak of burkitt's-like lymphoma in homosexual men. | four cases of burkitt's-like lymphoma (undifferentiated, monoclonal, b-cell tumours) in homosexual men were seen in a 9-month period in san francisco. one tumour contained both epstein-barr-virus nuclear antigen (ebna) and cytomegalovirus (cmv) antigen. another tumour contained ebna, and a third contained no viral antigen, but ebna and cmv antigens were detected in the overlying epithelium. this outbreak widens the array of neoplasms affecting immunosuppressed homosexual men and provides further ... | 1982 | 6125777 |
| phenotypic and functional deficiency of natural killer cells in patients with chronic fatigue syndrome. | natural killer (nk)3 cells are large granular lymphocytes that appear to play a significant role in the host's defense against viral infection. we performed an extensive phenotypic and functional characterization of nk cells on 41 patients with the chronic fatigue syndrome (cfs), or "chronic active epstein-barr virus infection" syndrome, and on 23 age- and sex-matched asymptomatic control subjects in an attempt to further characterize this illness. these studies demonstrated that a majority of p ... | 1987 | 2824604 |
| genetic polymorphism of natural epstein-barr virus isolates from infectious mononucleosis patients and healthy carriers. | we analyzed epstein-barr virus (ebv) genomes from lymphoblastoid cell lines isolated from patients with infectious mononucleosis and from healthy subjects from california, hawaii, and hong kong between 1970 and 1987. using genetic polymorphism as epidemiological markers, we found that several genotypes of ebv cocirculate in a community and that although most ebv strains isolated from california and southern china may be differentiated genotypically, there was no specific association between geno ... | 1988 | 2901499 |
| aids-associated non-hodgkin's lymphoma in san francisco. | the characteristics of acquired immunodeficiency syndrome-associated non-hodgkin's lymphoma in 84 patients diagnosed and treated at san francisco general hospital are presented herein. while the majority were high-grade b-cell lymphomas, one cutaneous t-cell and one peripheral t-cell lymphoma were observed. in addition, three other tumors were suspicious for t-cell lymphoma. sixty-seven percent of patients had stage iv disease, often at unusual sites. epstein-barr virus dna sequences were identi ... | 1989 | 2536124 |
| chronic fatigue syndrome in northern nevada. | the clinical and laboratory findings from studies of patients with chronic fatigue syndrome (cfs) from northern nevada are summarized. physicians caring for these patients have estimated that greater than 400 patients with cfs from northern nevada and nearby communities in california were identified between 1984 and 1988. as a result of these studies, a cluster of clinical and laboratory features associated with the illness in moderately to severely affected patients has been identified: profoun ... | 1991 | 1850542 |
| clinical, epidemiologic, and virologic studies in four clusters of the chronic fatigue syndrome. | the purpose of this study is to provide a case definition of chronic fatigue syndrome in an outbreak occurring in the nevada-california region to evaluate candidate etiologic agents and observe the natural history of the illness. | 1992 | 1323246 |
| epidemiological and biological study of acquired immunodeficiency syndrome-related lymphoma in the county of los angeles: preliminary results. | a population-based case control study of intermediate- and high-grade lymphoma in the county of los angeles, ca, was initiated in 1989. human immunodeficiency virus (hiv)-positive lymphoma patients are compared to hiv-negative lymphoma patients, to hiv-positive controls with acquired immunodeficiency syndrome but without lymphoma, and to hiv-positive asymptomatic individuals. the hiv-negative lymphoma cases are compared to neighborhood controls, who are matched in terms of age, sex, race/ethnici ... | 1992 | 1327509 |
| liver transplantation at california pacific medical center, san francisco, california. | a number of modifications in patient selection, operative technique, and immunosuppressive management have greatly contributed to the success of the liver transplant program at cpmc. graft rejection and the timely detection of ebv infection are ongoing problems in hepatic transplantation that are foci of active research in our field. to address these issues, our group is investigating the activity of cytokines and adhesion molecules using sophisticated molecular techniques, and we are developing ... | 1994 | 7547535 |
| genotypic analysis of epstein-barr virus isolates associated with nasopharyngeal carcinoma in chinese immigrants to the united states. | ebv genotypes of first- and second-generation chinese diagnosed with nasopharyngeal carcinoma in the united states were analyzed by pcr techniques. previous studies showed a geographical distribution of genotypically distinct sub-types of ebv. viruses detected at a higher frequency among chinese npc patients (cf) were distinguished from those found in the majority of caucasian npc patients (df) in the united states by polymorphisms in the bamhi f and i regions. exploiting this distinction, we an ... | 1994 | 7989111 |
| the epidemiology of hodgkin's disease. | much of the epidemiological heterogeneity of hd incidence reflects the behaviour of the ns subtype, at least in the usa. incidence variation across races (except asians) and time periods is most marked in this subtype. in young adults with hd, there is compelling evidence for social class modification of risk consistent with an infectious aetiology; limited data suggest that this effect occurs within the ns subtype, but considerable evidence indicates that it does not primarily involve ebv infec ... | 1996 | 8922237 |
| malignant neoplasms of the nasal cavity and paranasal sinuses: a series of 256 patients in mexico city and monterrey. is air pollution the missing link? | air pollution is a serious health problem in major cities in mexico. the concentrations of monitored criteria pollutants have been above the us national ambient air quality standards for the last decade. to determine whether the number of primary malignant nasal and paranasal neoplasms has increased, we surveyed 256 such cases admitted to a major adult oncology hospital located in metropolitan mexico city (mmc) for the period from 1976-1997 and to a tertiary hospital in monterrey, an industrial ... | 2000 | 10740168 |
| sinonasal nk/t-cell lymphomas in the united states. | sinonasal natural killer (nk)/t-cell lymphomas are common in asia and areas of south and central america but are rarely seen in the united states, where they have not been as well characterized. fifteen cases diagnosed in southern california were studied with respect to histologic features, immunophenotype, epstein-barr virus eber in-situ hybridization (ebv eber-ish), and t-cell receptor gamma chain (tcr-gamma) gene rearrangement. although ethnic background was available for only seven patients, ... | 2000 | 11075852 |
| non-hodgkin's lymphoma: pathogenesis, clinical presentation, and treatment. | 2001 | 11191128 | |
| prevalence of antibodies to four herpesviruses among adults with glioma and controls. | the authors previously reported statistically significant inverse associations between adult onset glioma and histories of chickenpox and shingles among 462 cases and 443 controls in the san francisco bay area adult glioma study (1991--1995) and a suggestive but nonsignificant inverse association with immunoglobulin g antibodies to varicella-zoster virus in a small subset of these cases. this report considers antibodies to four common herpesviruses (varicella zoster, herpes simplex, cytomegalovi ... | 2001 | 11447050 |
| no direct role for epstein-barr virus in american hepatocellular carcinoma. | epstein-barr virus (ebv) was recently linked to hepatocellular carcinogenesis in japanese patients. it is not clear whether ebv infection is also associated with hepatocellular carcinoma (hcc) occurring in american patients. we studied 41 cases of hcc from the los angeles area for evidence of ebv infection by in situ hybridization, immunohistochemistry, and polymerase chain reaction methods. of 41 cases, 16 were seropositive for hepatitis b virus surface antigen (39%), 9 of 29 tested were seropo ... | 2001 | 11583956 |
| population-based patterns of human immunodeficiency virus-related hodgkin lymphoma in the greater san francisco bay area, 1988-1998. | epidemiologic characteristics of human immunodeficiency virus (hiv)-related hodgkin lymphoma (hl) have not been examined in the greater san francisco bay area, a center of the hiv/acquired immunodeficiency syndrome (aids) epidemic, for a decade, despite changes in aids-associated diseases after the availability of highly active antiretroviral therapies (haart). | 2003 | 12872349 |
| exposure to childhood infections and risk of epstein-barr virus--defined hodgkin's lymphoma in women. | the role of epstein-barr virus (ebv) in hodgkin's lymphoma (hl) etiology remains unresolved as ebv is detected in only some hl tumors and few studies have tried to reconcile its presence with factors suggesting viral etiology (e.g., childhood social class, infection history). in a population-based case-control study of san francisco bay area women, we analyzed interview data by tumor ebv status. among 211 young adult cases, ebv-positive hl (11%) was associated with a single vs. shared bedroom at ... | 2005 | 15700307 |
| human immunodeficiency virus/acquired immunodeficiency syndrome and cancer: past, present, and future. | 2005 | 15769998 | |
| gastric adenocarcinoma among hmong in california, usa, 1988-2000. | this study examined gastric adenocarcinoma incidence, mortality, and tumor characteristics in the hmong population of california, 1988-2000. many hmong relocated to the united states at the conclusion of the vietnam war. resettlement difficulties encountered by hmong have included socioeconomic and healthcare issues. hmong are wary of western medicine and would resort to it as the last option, which may delay the diagnosis and treatment of diseases such as cancer. | 2005 | 15864719 |
| history of chickenpox and shingles and prevalence of antibodies to varicella-zoster virus and three other herpesviruses among adults with glioma and controls. | whether viruses or immunologic factors might cause or prevent human brain cancer is of interest. statistically significant inverse associations of adult glioma with history of chickenpox and immunoglobulin g antibodies to varicella-zoster virus have been reported. the authors evaluate associations of immunoglobulin g antibodies to varicella-zoster virus and three other herpesviruses among 229 adults with glioma and 289 controls in the san francisco bay area adult glioma study (1997-2000). cases ... | 2005 | 15870157 |
| racial/ethnic variation in ebv-positive classical hodgkin lymphoma in california populations. | epstein-barr virus (ebv) is detected in the tumor cells of some but not all hodgkin lymphoma (hl) patients, and evidence indicates that ebv-positive and -negative hl are distinct entities. racial/ethnic variation in ebv-positive hl in international comparisons suggests etiologic roles for environmental and genetic factors, but these studies used clinical series and evaluated ebv presence by differing protocols. therefore, we evaluated ebv presence in the tumors of a large (n = 1,032), racially a ... | 2008 | 18646185 |
| functional variants of the hmga1 gene and type 2 diabetes mellitus. | high-mobility group a1 (hmga1) protein is a key regulator of insulin receptor (insr) gene expression. we previously identified a functional hmga1 gene variant in 2 insulin-resistant patients with decreased insr expression and type 2 diabetes mellitus (dm). | 2011 | 21364139 |
| Evidence of genetic susceptibility to infectious mononucleosis: a twin study. | SUMMARYInfectious mononucleosis is a clinical manifestation of primary Epstein-Barr virus infection. It is unknown whether genetic factors contribute to risk. To assess heritability, we compared disease concordance in monozygotic to dizygotic twin pairs from the population-based California Twin Program and assessed the risk to initially unaffected co-twins. One member of 611 and both members of 58 twin pairs reported a history of infectious mononucleosis. Pairwise concordance in monozygotic and ... | 2011 | 22152594 |
| epstein-barr virus-associated hemophagocytic lymphohistiocytosis in los angeles county. | data on epstein-barr virus-related hemophagocytic lymphohistiocytosis (ebv-hlh) in adults in the united states remain very limited. a cluster of four cases of ebv-hlh was observed in a 4-month period at a tertiary center in los angeles county (la county) and the clinical and molecular characteristics identified in these cases are being described. ebv typing, immunophenotypic and molecular genetic studies were performed. diagnostic criteria that may be used to identify ebv as a cause of hlh in ad ... | 2012 | 22431026 |
| hodgkin lymphoma incidence in california hispanics: influence of nativity and tumor epstein-barr virus. | for classical hodgkin lymphoma (hl), migrant studies could elucidate contributions of environmental factors (including epstein-barr virus (ebv)) to the lower rates in non-whites. given the well-described etiologic complexity of hl, this research requires a large, immigrant population, such as california hispanics. | 2014 | 24722952 |