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the chinese epidemiological approach of nasopharyngeal carcinoma research and control.nasopharyngeal carcinoma (npc), the major cancer killer in cantonese chinese, represents one of the three cancer research priorities in china. apart from some fundamental research projects on the epstein-barr virus (ebv), their main efforts are epidemiologically and clinically oriented. major surveys in guangdong and guangxi provinces showed that high ebv/iga/vca serum levels can detect npc at an early stage of the disease. characterization of "precancerous lesions" in the nasopharynx and among ...19816264696
epidemiological studies of nasopharyngeal cancer in the guangzhou area, china. preliminary report.in the city of guangzhou (canton) and its surroundings nasopharyngeal cancer (npc) constitutes about 32% of all cancer and is therefore the most common kind of cancer. three types of etiological factors seem to be involved: 1) a hereditary factor, 2) epstein-barr virus, and 3) external factors in food and water. an epidemiological study has been started in the guangzhou area with interviews of npc cases, matching controls and mothers of the cases and controls concerning especially food and envir ...19892547276
[nasopharyngeal carcinoma (npc) mortality rate in two districts of guangdong province and their relation to iga antibody level against eb virus capsid antigen].based upon the retrospective investigation data, the npc mortality rate in the pearl river delta was found to be twice as high as that of chaoshan district. the positive rate of iga/vca antibody in the pearl river delta was also found to be significantly higher than that in the chaoshan district by viro-serological screening. the iga/vca antibody positive rate and mortality rate were concomitantly increased with age in the bracket of 30-59. accordingly, the authors assume that activation of infe ...19921319889
studies on etiological factors of nasopharyngeal carcinoma.a case-control study of nasopharyngeal carcinoma (npc) was performed in guangzhou, southern china in 1987 to 1989. we investigated 205 cases and an equal number of matched controls. epstein-barr virus (ebv) infection with positive iga against viral capsid antigen (vca-iga) was shown to be the most important predictor in npc. consumption of salted fish was also strongly associated with npc but not to the same extent as ebv. in order to investigate the possible carcinogenic effect of salted fish, ...19938390773
[detection of epstein-barr virus, cell proliferation and apoptosis in thymic tumors].to investigate the incidence of thymic tumors in guangzhou, its association with ebv infection and the cell proliferation and apoptosis characteristics of these tumors.199911869513
epstein-barr virus infection of sinonasal lymphoepithelial carcinoma in guangzhou.to investigate the prevalence of sinonasal lymphoepithelial carcinoma (snlec) in guangzhou, a high incidence area of nasopharyngeal carcinoma (npc), and to detect whether it is associated with epstein-barr virus (ebv) infection.200111780191
the 30-bp deletion variant: a polymorphism of latent membrane protein 1 prevalent in endemic and non-endemic areas of nasopharyngeal carcinomas in china.development of nasopharyngeal carcinoma (npc) is closely associated with epstein-barr virus (ebv) infection. however, npc occurs with a marked geographic and racial distribution, whereas ebv infection is ubiquitous in the world. this leads to a question whether certain subtypes of ebv have a greater potential to induce cell transformation. latent membrane protein 1 (lmp1) is an ebv-encoded oncogenic protein and its 30-bp deleted variant (del-lmp1) has been reported to be predominant in biopsies ...200211790455
genome-wide scan for familial nasopharyngeal carcinoma reveals evidence of linkage to chromosome 4.nasopharyngeal carcinoma (npc) occurs with high frequency in asian populations, especially among people of cantonese ancestry. in areas with high incidence, npc clusters in families, which suggests that both geography and genetics may influence disease risk. although the hla-bw46 locus is associated with increased risk of npc, no predisposing genes have been identified so far. here we report the results of a genome-wide search carried out in families at high risk of npc from guangdong province, ...200212118254
[detection of serum epstein-barr virus antibody level by elisa in normal populations and nasopharyngeal carcinoma patients in zhongshan city of china].to understand the distribution of epstein-barr virus (ebv) antibodies, namely ebna 1/iga, zebra/iga, ebna 1/igg in the populations of different ages or genders in zhongshan city of guangdong province, china.200212297441
the epstein-barr virus-associated gastric carcinoma in southern and northern china.in the present study, we examined the proportions of epstein-barr virus-associated gastric carcinomas (ebv-gcs) in guangzhou, southern china and shenyang, northern china, two areas differing markedly in nasopharyngeal carcinoma (npc) incidence. using in situ hybridization assay, the presence of ebv-encoded small rna (eber) was examined in 198, and 180 gastric cancer cases in guangzhou and shenyang, respectively. the proportion of ebv-gc in guangzhou (9%) was significantly higher than that in she ...200212375037
mutational events in lmp1 gene of epstein-barr virus in salivary gland lymphoepithelial carcinomas.it is still unknown what kinds of roles epstein-barr virus (ebv) infection that are highly specific to salivary gland lymphoepithelial carcinomas (lecs) play in their tumorigenesis. to clarify the significance of ebv in lecs, we paid particular attention to the lmp1 gene, which is responsible for triggering several pathways for activating transcription factors. sixty-one cases of ebv positive lecs confirmed by pcr and in-situ hybridization were collected from various areas of the world and studi ...200312740914
transcriptional expression of rpms1 in nasopharyngeal carcinoma and its oncogenic potential.the epstein-barr virus (ebv) bamhi a rightward transcripts (barts) were originally identified in c15 xenograft of nasopharyngeal carcinoma (npc) and easily detected in a wide variety of ebv latent infection and ebv-associated tumors. it had been reported that p31 cosmid containing barts immortalized monkey epithelial cells, but which particular gene among barts family participates in the transformation procedure remains to be identified. rpms1 is the only full-length cdna confirmed so far and on ...200515725729
[clinical analysis of 1,142 hospitalized cantonese patients with nasopharyngeal carcinoma].few large-scale epidemiologic investigations of nasopharyngeal carcinoma (npc) at high incidence region in guangdong province were reported in recent 20 years. this study was to summarize clinical data of a population of hospitalized cantonese npc patients,analyze the epidemiologic characteristics of npc in the high incidence region, and provide references for the prevention and treatment of npc.200616480587
correlation of immunophenotype of sinonasal non-hodgkin's lymphoma to epstein-barr virus infection.there are differences in the prevalence rate and composition of immunophenotypes of sinonasal non-hodgkin's lymphoma (nhl) depending on the geography. this study was to investigate the immunophenotypes of sinonasal nhls and their relationship to epstein-barr virus (ebv) infection in guangzhou, china.200717991313
prognostic implication of pretreatment titer of serum immunoglobulin a against epstein-barr virus capsid antigen in nasopharyngeal carcinoma patients in sihui, guangdong.currently, the serum immunoglobulin a against epstein-barr virus capsid antigen (ebv-vca/iga) is one of the most commonly used markers for diagnosis of nasopharyngeal carcinoma (npc). however, its value for prognostic implication in npc patients is unclear. this study was to evaluate the relationship between pretreatment titers of ebv-vca/iga and npc patients' survival.200919448418
the dominance of china 1 in the spectrum of epstein-barr virus strains from cantonese patients with nasopharyngeal carcinoma.nasopharyngeal carcinoma is a disease with a remarkable geographic and ethnic distribution, and has a high incidence in southern china. infection with epstein-barr virus (ebv) is an important contributing factor. the profile of ebv strains in cantonese patients from guangdong, the nasopharyngeal carcinoma endemic region in southern china, is described on the sequence variations in latent membrane protein 1 carboxyl-terminus. the results show that china 1 was the dominant ebv strain detected in b ...200919475622
clinicopathologic features and epstein-barr virus infection status of burkitt's lymphoma in guangzhou district.background and objective: sporadic burkitt's lymphoma (sbl) is uncommon and its relation to epstein-barr virus (ebv) is unknown in china. this study was to investigate the clinical presentation, morphologic features, immunophenotype and ebv infection status of sbl in guangzhou district, a prevalent area of ebv infection. methods: the clinical data of 21 sbl patients were reviewed. a panel of immunohistochemical staining was performed and ebv-encoded small rnas (ebers) in situ hybridization was a ...200919664325
association of distinctive epstein-barr virus variants with gastric carcinoma in guangzhou, southern china.to investigate the clinicopathologic features, epstein-barr virus (ebv) latency pattern and genome polymorphism of ebv-associated gastric carcinoma (ebvagc) in guangzhou, an endemic area of nasopharyngeal carcinoma (npc), an in situ hybridization assay of ebv-encoded small rna-1 (eber-1) was used to identify the presence of ebv in 676 consecutive gastric carcinoma cases. ebv-encoded proteins ebna1, ebna2, lmp1, and zebra were detected by immunohistochemistry. ebv genome polymorphism was also ana ...201020166192
[clinicopathologic study of 963 cases of mature t-cell and natural killer/t-cell lymphoma with respect to 2008 who classification of lymphoid neoplasms].to study the clinicopathologic features of various types of mature t-cell and natural killer (nk)/t-cell lymphoma in guangdong, china, with respect to the 2008 who classification of lymphoid neoplasms.201020654150
alcohol and tea consumption in relation to the risk of nasopharyngeal carcinoma in guangdong, china.to investigate whether alcohol and tea consumption has an etiological association with nasopharyngeal carcinoma (npc) in a high-incident population, a large scale case-control study was conducted. the study included 2846 individuals in guangdong province, china, with 1387 newly diagnosed cases of npc and 1459 frequency-matched controls. exposure histories of alcohol and tea consumption were obtained via personal interviews. information regarding socio-demographic characteristics (age, sex, educa ...201021110141
nasopharyngeal extranodal nk/t-cell lymphoma, nasal type: retrospective study of 18 consecutive cases in guangzhou, china.the aim of this study was to investigate the frequency and clinicopathologic features of nasopharyngeal extranodal nk/t-cell lymphoma, nasal type (nktcl), as well as dna sequence variation of epstein-barr virus (ebv) in neoplastic cells harboring in nktcls from guangzhou district.201021134987
[clinicopathologic features and protein expression study of epstein-barr virus-associated gastric carcinoma in guangzhou].to investigate the prevalence of epstein-barr virus (ebv)-associated gastric carcinomas in guangzhou, their clinicopathologic features and related protein expressions including dnmt1, p16, and cyclin d1.201021215093
prevalence and association of human papillomavirus 16, epstein-barr virus, herpes simplex virus-1 and cytomegalovirus infection with human esophageal carcinoma: a case-control study.recent research shows esophageal carcinoma (ec) as the ninth most common malignancy in the world. the association of viral infection and ec has been reported in the last 30 years. however, geographic variation in infection rates and the key mechanisms of the viral action have yet to be resolved. this study aimed to determine the prevalence and association of human papillomavirus 16 (hpv-16), herpes simplex virus 1 (hsv-1), epstein-barr virus (ebv) and cytomegalovirus (cmv) infection in the etiol ...201121455581
sporadic burkitt lymphoma in southern china: 12 years' experience in a single institution in guangzhou.aim to analyse the clinicopathological features of sporadic burkitt lymphoma (sbl). methods in a review of 1682 cases of non-hodgkin lymphoma diagnosed in the first affiliated hospital and zhongshan school of medicine, from 1998 to 2010, 20 cases (1.2%) of sbl were identified. histopathological examination, immunohistochemistry and in situ hybridisation were used to analyse the clinicopathological features of these cases. results of the 20 cases of sbl, 18 patients were male and two were female. ...201121653657
epstein-barr virus and breast cancer: serological study in a high-incidence area of nasopharyngeal carcinoma.we investigated iga and igg levels against ebv viral capsid antigen (vca) and nuclear antigen-1 (ebna-1) in serum of 223 women with breast cancer (bc) and 309 controls in guangzhou, china. vca iga levels were significantly associated with an elevated risk of bc, with adjusted ors (95%cis) of 1.70 (1.05-2.76) (seropositivity) and 2.21 (1.11-4.40) (unit increases in od value). this association was stronger among young, lean, and her2+ women. the ebna-1 iga levels in od value, but not seropositivit ...201121724319
epstein-barr virus genome polymorphisms of epstein-barr virus-associated gastric carcinoma in gastric remnant carcinoma in guangzhou, southern china, an endemic area of nasopharyngeal carcinoma.epstein-barr virus (ebv) is associated with a subset of gastric carcinoma which was defined as ebv-associated gastric carcinoma (ebvagc). the proportion of ebvagc in gastric remnant carcinoma (grc) was apparently higher than that in conventional gastric carcinoma (cgc) which occurs in the intact stomach. to clarify the possible mechanisms, 26 grc cases from guangzhou were investigated for the presence of ebv, and the ebv genome polymorphisms of ebvagc in grc were analyzed. besides, the clinicopa ...201121723347
the principal genetic determinants for nasopharyngeal carcinoma in china involve the hla class i antigen recognition groove.nasopharyngeal carcinoma (npc) is an epithelial malignancy facilitated by epstein-barr virus infection. here we resolve the major genetic influences for npc incidence using a genome-wide association study (gwas), independent cohort replication, and high-resolution molecular hla class i gene typing including 4,055 study participants from the guangxi zhuang autonomous region and guangdong province of southern china. we detect and replicate strong association signals involving snps, hla alleles, an ...201223209447
further evidence for the existence of major susceptibility of nasopharyngeal carcinoma in the region near hla-a locus in southern chinese.nasopharyngeal carcinoma (npc) is a multi-factorial malignancy closely associated with environmental factors, genetic factors and epstein-barr virus infection. human leukocyte antigen (hla) complex, specially the region near hla-a locus, was regarded as a major candidate region bearing npc genetic susceptibility loci in many previous studies including two recent genome-wide association (gwa) studies. to provide further evidence for the npc susceptibility in the region near hla-a locus based on o ...201222440091
beating 'guangdong cancer': a review and update on nasopharyngeal cancer.once endemic in southern china, nasopharyngeal cancer is becoming less prevalent in hong kong. this is probably due to a better understanding of the risk factors associated with the disease, its genomic landscape, advances in radiotherapy technology, and development of effective systemic agents. more specifically, the close relationship between epstein-barr virus and nasopharyngeal cancer opens up the possibility of using epstein-barr virus dna as a biomarker for early detection and monitoring o ...201728862144
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