Publications

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the fate of bakers' yeast in the intestine of man and of the white rat. 192416559053
the physiological rôle of vitamin b. part iv: the relation of certain dietary factors in yeast to growth of rats on diets rich in proteins. 192716743881
hepatic injury on a nutritional basis in rats.in forty-eight rats kept on a basal diet deficient in the vitamin b complex and supplemented with vitamin b(1) and riboflavin or with vitamin b(1), riboflavin and vitamin b(6), various pathological changes in the liver were observed. these changes were characterized mainly by parenchymatous and fatty degeneration, focal and massive necrosis, hyperemia and hernorrhage and, in some of the rats, by perilobular and condensation fibrosis. addition of yeast or peters' eluate (yeast extract) regularly ...193919870900
unsaturated fatty acids in the dietary destruction of n,n-dimethylaminoazobenzene (butter yellow) and in the production of anemia in rats.crude linoleic acid incorporated with or without butter yellow in a synthetic diet proved to be toxic for rats. the toxic effect manifested itself in loss of weight, progressive anemia of the secondary type, leucopenia, and pediculosis. it could be neutralized preventively and therapeutically by administration of yeast. the toxicity of the diet containing linoleic acid appears to be due to oxidative break-down products of the unsaturated fatty acid. the color of the same diet when it contained c ...194219871247
effects of yeast and food intake on experimental carbon tetrachloride cirrhosis of the liver in the rat. 194219970649
the effect on rats of a diet with a high content of protein derived from food yeast. 194620985911
comparative effects of liver and yeast on growth and length of survival of the immature thyroid-fed rat. 194720272018
the influence of dietary factors, especially brewer's yeast, cystine and b vitamins, on the course of chronic thallium poisoning in the rat. 195015403957
yeast in the production of dietary massive hepatic necrosis in rats. 195015422414
the nutritive properties of two yeasts used to produce massive dietetic liver necrosis in rats. 195114820869
the inhibitory action of some antimalarial drugs and related compounds on the hexokinase of yeast and of plasmodium berghei.of various antimalarial compounds tested, only proguanil failed to inhibit yeast hexokinase. the metabolite of proguanil, 10,580, was an effective inhibitor. some compounds tested which were without antimalarial activity were potent inhibitors of yeast hexokinase. the degree of inhibition increased as the time during which the enzyme had been in contact with the drug increased, and the inhibitory action of mepacrine was reduced when the concentration of atp was raised. the inhibition of yeast he ...195713413145
dietary hepatic necrosis of albino rats induced by japanese brewer's yeast. 195713486558
the effect of yeast on dental caries in the rat. 195913806549
heteromorphic change of adult fibroblasts by ribonucleoproteins.cultures of subcutaneous areolar fibroblasts from adult rats, when confronted in vitro with microsomes from rat liver or kidney, are changed heteromorphically so as to resemble cultures of nervous tissue. similar effects follow exposure to the deoxycholate-insoluble fraction of microsomes, and to purified rna from rat liver or from yeast. an equivalent ribonucleoside mixture has no heteromorphic effect. the degree of heteromorphosis can be related quantitatively to the amount of rna administered ...195913630930
[on experimental nutrition-conditioned liver necroses. iii. effect of a necrogenic yeast diet on the respiration and the p/o quotient of rat liver tissues]. 196013848437
[on the subject of the influence of ribonucleic acid from yeast on the thirty-day survival of totally irradiated rats. new research]. 196014420057
primary isolation of mycoplasma organisms (pplo) from mammalian sources.barber, t. l. (cornell university, ithaca, n.y.) and j. fabricant. primary isolation of mycoplasma organisms (pplo) from mammalian sources. j. bacteriol. 83:1268-1273. 1962.-mycoplasma (pplo) were isolated from cattle, pigs, sheep, rats, and dogs. a total of 39 isolates was obtained from 307 samples from 166 animals. of these, 24 isolates were from semen of bulls in an artificial breeding establishment; the other 15 were from various tissues of the animals mentioned. variations of two basal medi ...196213864846
ribonucleic acid: effect on conditioned behavior in rats.acquisition of a behavioral response motivated by shock was enhanced in rats chronically treated with yeast ribonucleic acid, and resistance to extinction was greater in rats so treated than in controls. this extends the role of ribonucleic acid to include a behavioral effect in laboratory mammals treated with a purified preparation from yeast.196314022783
experimental evaluation in laboratory animals of anti-inflammatory analgesic drugs. 196314163909
the biosynthesis of the benzoquinone ring of ubiquinone from p-hydroxybenzaldehyde and p-hydroxybenzoic acid in rat kidney, azotobacter vinelandii, and baker's yeast. 196414171457
[transhydrogenation of tpnh to dpn by lactate dehydrogenase in the liver and alcohol dehydrogenase in yeast]. 196414306579
[yeast-fungi as pathogenic agents in angola]. 19655886726
interactions of yeast extracts and their constituents with monoamine oxidase inhibitors. 19665919499
[a preparative procedure for the isolation of enriched preparations of aminoacyl-trna-synthetases from baker's yeast]. 19665999843
brewers yeast-induced inflammation in rats: investigation on some humoral and functional changes. 19675615991
bilateral lesion of anterior hypothalamus and regulation of body temperature in rats. 19675630844
glyceraldehyde-3-phosphate dehydrogenase variants in phyletically diverse organisms.electrophoretically distinct forms of glyceraldehyde-3-phosphate dehydrogenase (tdh) have been detected in turtle, perch, trout, spinach, and yeast. multiple forms were not detected in rat, rabbit, chicken, frog, honey bee, euglena, or escherichia coli. the combination of two different subunits into tetramers is a probable explanation for the five-membered sets usually detected in extracts exhibiting tdh multiplicity.19675341534
the effect of antioxidant deficiency on tissue lipid composition in the rat. ii. liver.the hepatic phospholipids of the antioxidant-deficient rat fed a source of both linoleate and linolenate showed a progressive net decrease in eicosapentaenoate, a progressive net increase in arachidonate, and there was a concomitant accumulation of fluorescent pigment of the lipofuscin or ceroid type in the tissue. an increased incorporation of isotopically labeled acetate into both the tetraenoic and pentaplus hexaenoic acid fractions was also noted, indicating that the disappearance of polyuns ...196717805733
effect of filipin on rat-liver and yeast mitochondria. 19685727376
different anticodons in purified valine trna fractions from yeast. 19685748830
[pharmacological studies on ribonucleic acid (rna) and related substances, with special reference to kr-yeast rna]. 19685749304
n-formylmethionyl transfer rna in mitochondria from yeast and rat liver. 19685760639
the occurrence of diphosphoinositide and triphosphoinositide in saccharomyces cerevisiae. 19684301226
a new anti-inflammatory agent 1-(4-chlorobenzoyl)-3-(5-tetrazolylmethyl) indole (bl-r743). 19695355568
[change in the blood picture of young rats on different protein diets]. 19695363906
yeast ribonucleic acid: analysis of effects on pole-climb avoidance behavior. 19705435876
safety evaluation of yeast grown on hydrocarbons. i. one-year feeding study in rats with yeast grown on gas oil. 19705453299
differential long-term effects of d-chloramphenicol on the biogenesis of mitochondria in normal and regenerating rat liver.1. normal and partially hepatectomized rats (150g) were injected daily with d-chloramphenicol (20mg) for a period of 4 weeks, in order to investigate whether defective mitochondria could be induced in vivo in higher organisms as in yeast, and to measure the degree of inhibition of the mitochondrial function thus obtained. 2. the antibiotic did not affect growth and increased the amount of liver protein without changing the mitochondrial yield. 3. the respiration of isolated mitochondria from reg ...19705488686
safety evaluation of yeast grown on hydrocarbons. ii. one-year feeding study in rats with yeast grown on pure n-paraffins. 19705492924
hydrolysis of nucleoside di- and tri-phosphates by alkaline inorganic pyrophosphatases of rat liver and yeast. 19705416894
the stereochemistry of hydrogen elimination from c-7 in cholesterol and ergosterol biosynthesis.the synthesis of [7alpha-(3)h]lanosterol is described. it is shown that in the conversion of [7alpha-(3)h,26,27-(14)c(2)]lanosterol into cholesterol by a rat liver system, it is the 7beta-hydrogen atom that is predominantly removed. on the other hand, the conversion of doubly labelled lanosterol into ergosterol by whole yeast cells results in the loss of the 7alpha-hydrogen atom. these results therefore suggest that the c-7 hydrogen atoms with opposite stereochemistry are labilized by the rat li ...19705419748
chromatographic fractionation of transfer rna on the macroreticular polystyrene ion-exchange resin amberlyst a-21. 19714943258
the luminescence of zinc-porphyrins in microorganisms and plants: phosphorescence and delayed fluorescence. 19714949526
comparative studies on mammalian and yeast phenylalanine transfer ribonucleic acids. 19714327495
hexose-atp phosphotransferases: comparative aspects. ii. cross-reactivity of hexokinases from a variety of species with antisera to yeast hexokinase. 19715001183
effect of dried baker's yeast and skimmed milk powder on the lifespan of rats. 19725081214
hexose-atp phosphotransferases: comparative aspects. 3. interrelationships of animal hexokinases. 19724627638
[action of brain alkaline rnase on various rnas and synthetic polyribonucleotides]. 19724575747
chemical composition of candida utilis and the biological quality of the yeast protein. 19725041282
lysosomal localization of -fructofuranosidase-containing liposomes injected into rats.yeast beta-fructofuranosidase (invertase) or (131)i-labelled albumin were entrapped into liposomes composed of phosphatidylcholine, cholesterol and phosphatidic acid. of the beta-fructofuranosidase activity in the liposomal preparations 96-100% was latent. the following observations were made in experiments with rats injected with protein-containing liposomes. 1. after injection of beta-fructofuranosidase-containing liposomes (220 units or 1.5mg of beta-fructofuranosidase and 17.5mg of lipid), b ...19724646772
in vitro phagocytosis and intracellular fate of variously encapsulated strains of cryptococcus neoformans.five isolates of cryptococcus neoformans type a with stable capsular thicknesses were used. three of the isolates had capsules of medium size, one had a minimal capsule, and the other, a large capsule. peritoneal exudate cells from lewis rats were cultured on cover slips in leighton tubes containing medium 199 and 20% fresh, isologous normal rat serum. yeast cells were added to the leighton tube cultures, and, 2 hr later, the extracellular yeasts were rinsed out. cover slips were removed from so ...19724564677
isolation of a distinct rifampicin-resistant rna polymerase from mitochondria of yeast, neurospora and liver. 19724262372
on the role of alcohol dehydrogenase in omega-oxidation of fatty acids. 19724565405
[effect of ziram on mitochondrial functions]. 19724111302
isolation and partial characterization of a 51cr complex from brewers' yeast. 19734588213
transfer rna: evidence for decreasing size variation during evolution. 19734620077
an enzymatic method for measuring picomole quantities of acetylcholine and choline in cns tissue. 19734358017
pharmacological properties of imidazole. i. analgesic and anti-inflammatory actions. 19734761778
the effect of substitution at c-2 of d-glucose 6-phosphate on the rate of dehydrogenation by glucose 6-phosphate dehydrogenase (from yeast and from rat liver).1. the deoxyfluoro-d-glucopyranose 6-phosphates are substrates for both yeast and rat liver glucose 6-phosphate dehydrogenase. 2. the v(max.) values (relative to d-glucose 6-phosphate) were determined for a series of d-glucose 6-phosphate derivatives substituted at c-2. the v(max.) values decreased with increasing electronegativity of the c-2 substituent. this is consistent with a mechanism involving hydride-ion transfer. 3. 2-deoxy-d-arabino-hexose 6-phosphate (2-deoxy-d-glucose 6-phosphate) sh ...19734578852
rna fractionation on reversed-phase columns. 19734271855
the structure of mitochondrial atpase. 19734273937
pyruvate carboxylase. specific inactivation of acetyl coenzyme a-dependent oxylacetate synthesis during modification of the enzyme by trinitrobenzene sulfonate. 19734588687
studies on rat liver phenylalanyl transfer ribonucleic acid synthetase. ii. further purification, substrate specificity, and effects of substrates on heat inactivation. 19734350653
some properties of seryl-trna synthetase from rat liver. 19734353051
80s-ribosomal proteins. 19734605464
kinetic analysis of partially purified glucose-6-phosphate dehydrogenases from rat muscle, adipose tissue and liver, and from baker's yeast. 19734149160
[organotypic culture of normal liver from newborn rats]. 19734196412
studies on the microsomal electron-transport system of anaerobically grown yeast. ii. purification and characterization of cytochrome b5. 19744609979
products of rat liver mitochondrial protein synthesis: electrophoretic analysis of the number and size of these proteins and their solubility in chloroform: methanol. 19744611350
enzymatic acylation of oxidized-reduced transfer ribonucleic acid by escherichia coli, yeast, and rat liver synthetases occurs almost exclusively at the 2'-hydroxyl. 19744611487
[relationships between the quality of food proteins and the incorporation of 14c-leucine into the liver and muscle proteins of growing rats]. 19744616179
enhancement by rat liver preparations of the gene conversion frequency induced by ethyl methanesulphonate in saccharomyces cerevisiae. 19744366539
biosynthesis of myo-inositol in rat mammary gland. isolation and properties of the enzymes. 19744372945
total reconstitution of copper-zinc superoxide dismutase. 19744373464
the biosynthesis of mitochondrial cytochromes. 19744376287
kinetics, mechanism, and regulation of rat skeletal muscle hexokinase. 19744594125
the radioiodination of ribopolymers for use in hybridizational and molecular analyses. 19744594497
substrate stereochemistry of 3-hydroxy-3-methylglutaryl-coenzyme a synthase. 19744597848
trna methyltransferases. 19744603294
the hyperglycemic effect of 1-deoxy-d-manno-heptulose. inhibition of hexokinase, glucokinase, and insulin release in vitro. 19744609583
reversal of yeast-induced motor impairment in rats as a test for narcotic and non-narcotic analgesics. 19744155750
biochemical mutants: an approach to mitochondrial energy coupling. 19744279109
structural analyses of mammalian ribosomal ribonucleic acid and its precursors. nucleotide sequence of ribosomal 5.8 s ribonucleic acid.the nucleotide sequence of ribosomal 5.8 s rna (also known as 7 s or 5.5 s rrna) from novikoff hepatoma ascites cells has been determined to be (see article). estimations of the secondary structure based upon maximized base pairing and the fragments of partial ribonuclease digestion indicate that there may be five base-paired regions in the molecule, three forming a folding of the termini and two forming secondary hairpin loops. the sequence of novikoff hepatoma 5.8 s rrna is about 75% homologou ...1975171258
mutagenicity assays on fluorescent whitening agents using microorganisms.six fluorescent whitening agents (fwas) have been re-examined for their activity as inducers of cytoplasmic petite mutants and mitotic gene conversion in diploid yeast saccharomyces cerebisiae and reversion from auxotrophy to prototrophy in neurospora crassa, escherichia coli and salmonella typhimurium. the results provide no indication that the fwas examinded produce mutagenic changes or any other alterations in the gene material. in a recent re-examination with salmonella using the method of a ...1975132347
binding of [3h]benzo(a)pyrene to natural and synthetic nucleic acids in a subcellular microsomal system.several carcinogens are bound covalently to cellular nucleic acids. this is also the case with polycyclic hydrocarbon carcinogens, but their precise mechanism of in vivo activation to reactive forms and the structure(s) of the nucleic acid adducts are not known. this study demonstrates that in the presence of rat liver microsomes and reduced nicotinamide adenine dinucleotide phosphate there is covalent attachment of tritiated benzo(a)pyrene (bp) to transfer rna, dna, certain synthetic polyribonu ...1975238738
hepatic nucleases. extrahepatic origin and association of neutral liver ribonuclease with lysosomes.in the large granule fraction of rat liver, the density distribution of inhibitor-sensitive neutral ribonuclease is similar to that for acid hydrolases and its density distribution is similarly modified by triton wr-1339 accumulation in lysosomes. particulate neutral ribonuclease is latent; the enzyme is unmasked by very low digitonin concentrations or hypoosmotic shock. these observations demonstrate that the bulk of liver neutral ribonuclease is associated with the lysosomal system. in view of ...19751273
active site-specific reagents and transition-state analogs for enolase. 19751092960
an approach to the design of acaricidal enzyme inhibitors. 1975773646
[ribonuclease activity following partial hepatectomy in the liver of healthy and alloxan diabetic rats and histological findings in the islets of langerhans (author's transl)].question: what changes in the level of ribonuclease activity (rnase activity) can be observed in the regenerating liver of healthy and alloxan diabetic rats following partial hepatectomy? what coincidental alterations of the ratio a-cells to b-cells do occur in the islets of langerhans? materials and methods: 120 male wistar rats of averagely 180 g body weight were fed a standard diet ("rehbrücke") with drinking water ad libitum. after deprivation of food for 15 hours the animals were sacrificed ...1975786709
safety evaluation of yeast grown on hydrocarbons. iv. two-year feeding and multigeneration study in rats with yeast grown on pure n-paraffins. 19751205436
the isolation of large polysomes in high yield from unfractionated tissue homogenates.it was found that if large quantities of both exogenous rna and mg-2+ were present during gentle tissue homogenization, the subsequent addition of deoxycholate to the whole homogenate produced a viscous mass from which polysomes could be isolated in large yields. these polysomes were substantially less degraded than those isolated by previous methods. in the case of rat liver, 15 ribosomes per mrna was the species present in highest concentration. the parameters of this method were investigated ...19751095068
putrescine-insensitive s-adenosyl-l-methionine decarboxylase from tetrahymena pyriformis.extracts of tetrahymena pyriformis contain a soluble s-adenosyl-l-methionine decarboxylase which, in contrast to the enzyme from most eukaryotic organisms, is not stimulated by putrescine or spermidine. the protozoan adenosylmethionine decarboxylase, unlike the putrescine-insensitive enzyme form escherichia coli, did not require any metal ions for catalytic activity either. adenosylmethionine decarboxylase from tetrahymena resembled the prokaryotic enzyme as far the inhibition by methylglyoxal b ...1975813467
structure of the fluorescent nucleoside of yeast phenylalanine transfer ribonucleic acid. 19751092270
sequence homology of nuclear and mitochondrial dnas of different yeasts.1. both nuclear and mtdna of four different yeasts show approximately 10% homology as measured by dna-dna filter hybridization. these homologous sequences are mainly attributable to the ribosomal cistrons. 2. melting curve analysis shows that the heterologous mitochondrial dna-dna hybrids contain several times more mismatching than the nuclear dna-dna hybrids. 3. dna-rrna hybridization shows that the sequences of the ribosomal cistrons in both the nuclear and the mitochondrial genome have been c ...19751092349
a glyoxalase i inhibitor of a new structural type produced by streptomyces.many streptomyces strains produced an inhibitor of crude glyoxalase prepared from rat liver which did not inhibit glyoxalase i prepared from yeast. another inhibitor, c11h14o6, which inhibited glyoxalases prepared from both rat liver and yeast was obtained from a cultured broth of streptomyces griseosproeus and crystallized. preincubation of this inhibitor with reuduced glutathione increased its inhibitory activity, which suggested its reaction with reduced glutathione. it showed a strong inhibi ...19751102510
site of aminoacylation of trnas from escherichia coli with respect to the 2'- or 3'-hydroxyl group of the terminal adenosine.a method is presented by which the site of primary attachment of the amino acids with respect to the 2'- or 3'-hydroxyl group of the terminal adenosine of e. coli trnas can be determined. it is found that the aminoacyl-trna synthetases (ec 6.1.1.-) with specificity for arg, asn, ile, leu, met, phe, thr, trp, and val attach the amino acid to the 2'-position; those with specificity for gly, his, lys, and ser attach the amino acid to the 3'-position; and that tyr and cys can be enzymatically attach ...19751103137
structural properties of pyruvate carboxylases from chicken liver and other sources.varieties of pyruvate carboxylase [pyruvate: co2 ligase (adp-forming), ec 6.4.1.1] obtained from the livers of several species of vertebrates, including humans, all show the same basic structure. they are composed of large polypeptide chains of molecular weights ranging from 1.2 to 1.3 x 10(5) for the different varieties of the enzyme. the native form of the enzyme appears to be a tetramer with a molecular weight of about 5 x 10(5). in the case of pyruvate carboxylase from chicken liver each pol ...19751105579
synthesis of a mixed disulfide of egg white lysozyme and glutathione - a model substrate for enzymatic reduction of protein mixed disulfides. 19751095406
mast cell sensitizing antibody (mcsab) response in experimental candidiasis: chromatographic studies.a single dose of the yeast-like fungus candida albicans (ca), mixed with complete freund's adjuvant (cfa), and inoculated into guinea-pig foot-pads, provoked the productions of homologous mast cell sensitizing antibodies (mcsab) present in the psii-globulin fraction only, and of agglutinins localized in the same fraction. heterologous mcsab and skin-sensitizing antibodies detectable by passive cutaneous anaphylaxis (pca) were constantly absent. these facts are in contradiction to results of prev ...19751098354
comparison of membrane organization in mitochondria from yeast and rat liver by nuclear magnetic resonance spectroscopy.proton magnetic resonance (pmr) and carbon-13 magnetic resonance (cmr) spectra of intact, unsonicated yeast and rat liver motochondria show differences which may be correlated with the composition of the membranes. high resolution pmr and cmr signals in intact yeast mitochondria have been assigned to regions of fluid lipid-lipid interaction on the basis of spectra of extracted lipid and protein, and the temperature dependence of nmr signals from the intact membrane. pmr spectra suggest that abou ...19751104837
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