Publications

experimental focalized myocardial lesions produced with streptococcus mitis.	1. by the intravenous injection into rabbits of streptococcus mitis, we have produced focalized myocardial lesions which are identical with those caused by the injection of streptococcus rheumaticus, and with those produced by bracht and wächter with streptococcus viridans. 2. the lesions differ from those which we produced by injections of streptococci from the chicago epidemic of sore throat (epidemic streptococcus). 3. the lesions are not identical with aschoff bodies and are easily different ...	1914	19867783
normal flora of the nose, throat, and lower intestine of dogs.	clapper, w. e. (the lovelace foundation for medical education and research, albuquerque, n.m.) and g. h. meade. normal flora of the nose, throat, and lower intestine of dogs. j. bacteriol. 85:643-648. 1963.-an attempt was made to isolate and identify the complete normal flora of the rectum, nose, and throat of beagles. for primary isolation, 12 different kinds of media were used. incubation of blood agar plates and slants anaerobically, and of thioglycolate broth aerobically, allowed the growth ...	1963	14042944
establishment of human indigenous bacteria in germ-free mice.	gibbons, r. j. (forsyth dental center and harvard school of dental medicine, boston, mass.), s. s. socransky, and b. kapsimalis. establishment of human indigenous bacteria in germ-free mice. j. bacteriol. 88:1316-1323. 1964.-thirteen strains of bacteria indigenous to the gingival crevice area of man were tested for their ability to establish as monocontaminants in germ-free mice. three facultative organisms, streptococcus mitis, staphylococcus albus, and a "diphtheroid," established, as well as ...	1964	14234787
experimental transient bacteraemias in human subjects with clinically healthy gingivae.	thirty-six subjects with no evidence of clinical gingival inflammation underwent a standardized toothbrushing procedure. blood specimens, obtained from a vein in the antecubital fossa during the last 30 seconds of brushing, were cultured under aerobic and stringent anaerobic conditions. three subjects exhibited detectable bacteraemias, propionibacterium sp. being isolated from two of the subjects, while actinomyces sp., streptococcus sanguis and streptococcus mitis were isolated from the third. ...	1979	285080
characterization of tufted streptococci isolated from the "corn cob" configuration of human dental plaque.	streptococci isolated from "corn cob" configurations of human dental plaque possess a polar fibrillar tuft extending 100 to 150 nm from one pole of the cell. the two strains studied were physiologically related to the streptococcus sanguis-streptococcus mitior group and were most similar to streptococcus mitis atcc 903. the corn cob streptococci were serologically related to s. sanguis serotype 1. the polar tuft contained at least two antigenically distinct components, one serologically related ...	1980	6987171
effect of human saliva on glucose uptake by streptococcus mutans and other oral microorganisms.	we examined the effects of human whole salivary supernatant and parotid fluid on glucose uptake by streptococcus mutans, streptococcus sanguis, streptococcus mitis, actinomyces viscosus, staphylococcus aureus, and escherichia coli. the following three effects of saliva were observed: (i) inhibition of glucose uptake (s. mutans, s. sanguis), (ii) promotion of a transient, rapid (0 to 30 s) burst of glucose uptake (s. mutans, s. sanguis), and (iii) enhancement of glucose uptake (s. mitis, a. visco ...	1981	7012014
adsorption of lysozyme from human whole saliva by streptococcus sanguis 903 and other oral microorganisms.	several strains of streptococcus sanguis, streptococcus mutans, streptococcus mitis, actinomyces viscosus, and actinomyces naeslundii plus fresh isolates of streptococcus salivarius were surveyed for their abilities to deplete lysozyme from human-whole-saliva supernatant. bacteria were incubated in saliva for 60 min at 37 degrees c and then removed by centrifugation, and the recovered supernatant solutions were assayed for lysozyme activity by using whole cells of micrococcus lysodeikticus as th ...	1982	7076291
predominant microflora associated with human dental periapical abscesses.	the microflora of periapical abscesses of teeth free of periodontal disease was studied. permucosal aspiration of abscess contents and anaerobic cultural, microscopic, and biochemical techniques indicated a mixed but somewhat specific and relatively limited facultative and obligate anaerobic flora with fusobacterium nucleatum and streptococcus mitis as a frequent pair.	1982	7096563
prevalence of viridans streptococci exhibiting lactose-inhibitable coaggregation with oral actinomycetes.	fresh oral isolates from human dental plaque were selected on the basis of their spherical morphology. in a double-blind experiment, their species identity and ability to coaggregate with human oral actinomyces viscosus and actinomyces naeslundii were determined. of the 110 isolates characterized, 30 were identified as either streptococcus mutans, streptococcus anginosus-constellatus, or veillonella parvula; none of these coaggregated with the actinomycetes. the remaining 80 isolates were identi ...	1983	6409806
interbacterial adhesion between pseudomonas aeruginosa and indigenous oral bacteria isolated from patients with cystic fibrosis.	interbacterial adhesion between strains of pseudomonas aeruginosa and strains of indigenous oral bacteria, both of which were isolated from the oral cavity of cystic fibrosis patients, was investigated by the phenomenon of the coaggregation reaction. a total of 22 strains of p. aeruginosa were isolated from the oral cavity of 17 patients and examined for their abilities to coaggregate with 5 strains each of streptococcus sanguis, streptococcus mitis, actinomyces viscosus, and actinomyces naeslun ...	1987	3105855
selective modulation of bacterial attachment to oral epithelial cells by enzyme activities associated with poor oral hygiene.	the present investigation explored the hypothesis that elevated levels of certain enzymes in the gingival crevicular environment of individuals with poor oral hygiene and/or gingival inflammation may modify the surfaces of epithelial cells and thereby modulate the types of bacteria which attach and colonize. buccal epithelial cells treated with neuraminidase and certain proteases were used as a model for study. bacteria studied included streptococcus sanguis and streptococcus mitis which have be ...	1990	2141877
microflora associated with experimental root surface caries in humans.	this study describes the microflora from actively progressing root surface caries lesions, in which mineral loss had been determined by quantitative microradiography. the caries lesions were produced experimentally in root surface specimens from human molars inserted in lower partial dentures carried for 3 months by six elderly individuals. a total of 780 bacterial isolates were identified from 13 plaque samples, collected with a punch technique, and six dentin samples. the composition of the mi ...	1990	2341169
inhibitory effect of human plasma and saliva on co-aggregation between bacteroides gingivalis and streptococcus mitis.	the effect of human plasma and saliva on co-aggregation between bacteroides gingivalis and streptococcus mitis was studied by means of a turbidimetric assay. the co-aggregation activity was obtained from the maximum slope of the absorbance vs. time curve. its dependence on ph, temperature, and ionic strength was examined, and the number of bacteroides cells in relation to the number of streptococcus cells resulting in optimal co-aggregation was established. co-aggregation inhibition experiments ...	1990	2384623
characterization of infectious crystalline keratitis caused by a human isolate of streptococcus mitis.	streptococcus mitis isolated from a human with infectious crystalline keratitis was injected intrastromally into corneas of adult new zealand white rabbits that were treated with tetracycline hydrochloride, methylprednisolone acetate, or a combination of tetracycline and methylprednisolone. animals were followed up for up to 44 days; untreated corneas and those treated with tetracycline developed no disease or "fluffy" stromal infiltrates with overlying epithelial defects representing an abscess ...	1991	1714271
secretory iga adsorption and oral streptococcal adhesion to human enamel and artificial solid substrata with various surface free energies.	in this paper, secretory iga adsorption from a single component siga solution and from human whole saliva onto human enamel and artificial solid substrata with various surface free energies was studied as a function of time. elisa indicated that screening or displacement of adsorbed siga by other salivary proteins occurred only on low surface free energy substrata, not on high surface free energy substrata such as enamel. in addition, the adhesion of three oral streptococcal strains (streptococc ...	1991	1772830
clinical and microbiological findings on newly inserted hydroxyapatite-coated and pure titanium human dental implants.	the clinical and microbiologic features of 30 hydroxyapatite-coated root-form endosseous dental implants (tri-stage) were compared to 10 similar pure titanium implants without hydroxyapatite coatings. in 7 of 9 partially edentulous patients studied, pure titanium fixtures were placed adjacent to hydroxyapatite-coated implants. implants in the maxilla were submerged beneath mucosal tissues after implant placement for a minimum of 6 months, and in the mandible for at least 4 months. all patients w ...	1991	1843465
inhibitory effects of human salivary histatins and lysozyme on coaggregation between porphyromonas gingivalis and streptococcus mitis.	the effects of histatins on coaggregation between porphyromonas gingivalis 381 and streptococcus mitis atcc 9811 were investigated by using a turbidimetric assay. the coaggregation activity was significantly inhibited by histatins 5 and 8 and strongly by lysozyme. tritium-labeled histatin 8 bound to p. gingivalis cells but not to s. mitis cells.	1991	1879942
identification of proteases from periodontopathogenic bacteria as activators of latent human neutrophil and fibroblast-type interstitial collagenases.	activation of latent human fibroblast-type and neutrophil interstitial procollagenases as well as degradation of native type i collagen by supra- and subgingival dental plaque extracts, an 80-kda trypsinlike protease from porphyromas gingivalis (atcc 33277), a 95-kda chymotrypsinlike protease from treponema denticola (atcc 29522), and selected bacterial species commonly isolated in periodontitis was studied. the bacteria included were prevotella intermedia (atcc 25261), prevotella buccae (es 57) ...	1992	1398963
cytokine induction by extracellular products of oral viridans group streptococci.	during an etiological study of kawasaki disease (mucocutaneous lymph node syndrome [mcls]), we found that dominant viridans streptococcal strains on tooth surfaces and in the throat of both mcls patients and non-mcls control children formed erythrogenic and biologically active, extracellular products. in this study, we demonstrated that erythrogenic culture supernatant concentrates of representative strains (two streptococcus mitis and two streptococcus oralis), when injected intravenously, indu ...	1993	8225600
intravenous teicoplanin does not prevent clostridium difficile associated diarrhea.	a 59-year-old man with the diagnosis of endocarditis of the mitral valve due to streptococcus mitis was treated with penicillin g, gentamicin, and later with clindamycin as inpatient for 3 weeks. thereafter outpatient therapy with parenteral teicoplanin 3 x per week was initiated. after 17 days of teicoplanin treatment he developed severe diarrhea, and stool samples were positive for clostridium difficile toxin. in addition to the ongoing parenteral therapy with teicoplanin, oral teicoplanin was ...	1994	7894224
the role of the carbohydrate chains in complement (c3) fixation by solid-phase-bound human iga.	in contrast to antigen-antibody complexes containing native human iga, solid-phase-deposited iga activates the alternative complement pathway and binds c3b. to investigate the role of carbohydrate chains in this, various human iga preparations were treated with neuraminidase alone or together with n-glycanase or o-glycanase, or with mixed glycosidases from the oral bacterium, streptococcus mitis. depletion of oligosaccharides was determined by carbohydrate analysis. removal of sialic acid and n- ...	1994	7927504
[endocarditis caused by cardiobacterium hominis].	the incidence of endocarditis due to cardiobacterium hominis is probably underestimated because clinical presentations vary greatly and culture of this gram negative germ is difficult. a 48-year-old man with a past history of post-streptococcic aortic regurgitation was hospitalized twice within 1 week for fever (38 degrees c) and junctional tachycardia which responded to amiodarone. subsequently, infero-apical necrosis was documented. based on the result of the laboratory tests, coronary embolis ...	1994	8208692
the effect of indigenous bacterial populations on buccal epithelial cells on subsequent microbial adhesion in vitro.	despite the numerous investigations on the adhesion of microorganisms to buccal epithelial cells, it is difficult to correlate different results, as disparate adherence values have been reported for a given organism. as one reason for this disparity may be the indigenous or natural bacterial populations on human buccal epithelial cells, the effect of the latter on subsequent microbial adherence in vitro was examined. there was a highly significant correlation between the degree of natural bacter ...	1994	7478764
identification of pioneer viridans streptococci in the oral cavity of human neonates.	three hundred and sixty-seven strains of pioneer streptococci isolated from the mouths of 40 healthy, full-term infants during the first month of life were examined by two taxonomic schemes that incorporated biochemical and physiological characteristics, iga1 protease production and glycosidase activities. streptococcus mitis biovar 1 and s. oralis comprised 55.0% of the pioneer streptococci isolated from neonates. s. salivarius constituted 25.3% of the isolates, while s. anginosus, s. mitis bio ...	1995	7739028
immunopathological activities of extracellular products of streptococcus mitis, particularly a superantigenic fraction.	previously, we prepared extracellular products, fractions f-1 and f-2 of streptococcus mitis 108, an isolate from the tooth surface of an infant, and showed that f-1 exhibited inflammatory cytokine-inducing activities. in the present study, we present evidence that fraction f-2 induced human t-cell proliferation in the presence of irradiated human peripheral blood mononuclear cells and selectively activated t cells bearing v beta 2 and v beta 5.1 in the t-cell receptor. f-1, on the other hand, s ...	1995	7868248
cross-reactivity between human sialyl lewis(x) oligosaccharide and common causative oral bacteria of infective endocarditis.	the expression of sialy-lewis(x) (sle(x); neu5ac alpha 2-3 gal beta 1-4) (fuc alpha 1-3) glcnac-r) on oral bacteria producing infective endocarditis was determined by a whole-cell enzyme linked immunosorbent assay and an immunoelectron microscopy using the well-characterized anti-sle(x) monoclonal antibody snh-3 (mab snh-3; igm class). mab snh-3 reacted strongly with whole cells of oral bacteria: streptococcus sanguis, streptococcus mutans, streptococcus mitis, streptococcus salivarius, streptoc ...	1995	8589666
induction of lymphocytes cytotoxic to oral epithelial cells by streptococcus mitis superantigen.	the preparation of a superantigenic fraction f-2 from the culture supernatant of streptococcus mitis 108, a fresh isolate from human tooth surfaces, was reported previously. now, to determine the possible pathogenic role of the superantigen in oral mucosal diseases, we examined the cytotoxic effects of human peripheral blood t-cells activated with f-2 on human oral epithelial cells. t-cells activated with f-2 were cytotoxic to the human squamous carcinoma ho-1-n-1 cells derived from the oral muc ...	1996	8675804
induced candidosis in mice with artificially established oral flora.	the aim of this study was to gauge the effect of an artificially established flora, unnatural for mice, on the induction of oral candidosis in mice. four groups of balb/c mice were compared; conventional candida albicans-free mice, "germ-free" mice which had been inoculated with candida-free human saliva, germ-free mice which had been exposed to a cocktail of streptococcus mitis, s. sobrinus and s. sanguis, and uncontaminated germ-free mice. after exposure to c. albicans via drinking water, the ...	1996	9462024
does assessment of microbial composition of plaque/saliva allow for diagnosis of disease activity of individuals?	microbiological tests are limited in their applicability in the assessment of caries activity and in caries prediction. they can be effective in group of persons with high or low caries experience. the reasons for the limitation of microbiological tests rests with unique characteristics of the microflora and local environments of the oral cavity, which will modify the cariogenicity of plaque in an individual. thus, high numbers of s. mutans may be associated with the development of a lesion at a ...	1997	9088695
acute phlegmonous jejunitis and viridans streptococcal peritonitis associated with bronchial carcinoma.	a 61-y-old man developed acute non-specific phlegmonous jejunitis associated with relatively mild diffuse peritonitis. bacteriological cultures of the abundant peritoneal fluid resulted in only growth of viridans streptococci (streptococcus mitis and s. salivarius). antibiotic treatment had a favourable effect, but a hitherto unknown bronchial cancer led to his death 5 months later. it is assumed that this peculiar case was the result of the immunosuppressive effect related to the malignant neop ...	2000	10959654
adhesion in vitro of oral streptococci to porcelain, composite resin cement and human enamel.	we investigated the initial adhesion in vitro of oral streptococci to porcelain inlays. four strains of streptococci, streptococcus mitis nctc12261, streptococcus oralis atcc9811, streptococcus sanguis atcc10556 and streptococcus sobrinus omz176, were used in this study. the disc specimens were made of porcelain, composite resin cement and human enamel. these specimens, with or without a saliva-coat, were immersed in a suspension of each streptococci strain at 37 degrees c for 1 hr, and the numb ...	2000	11816366
binding of oral streptococci to human fibrinogen.	the interaction of oral streptococci with human fibrinogen was investigated. streptococcus gordonii was chosen as a representative species to study the binding to fibrinogen. s. gordonii dl1 adhered to immobilized fibrinogen and bovine serum albumin. binding to immobilized fibrinogen was saturable, concentration and temperature dependent. the binding of s. gordonii dl1 to fibrinogen was inhibited by anti-fibrinogen antibody. heating of the bacteria for 1 h at 95 degrees c resulted in 90% inhibit ...	2001	11240861
one of two human lactoferrin variants exhibits increased antibacterial and transcriptional activation activities and is associated with localized juvenile periodontitis.	the iron-binding protein lactoferrin is a ubiquitous and abundant constituent of human exocrine secretions. lactoferrin inhibits bacterial growth by sequestering essential iron and also exhibits non-iron-dependent antibacterial, antifungal, antiviral, antitumor, anti-inflammatory, and immunoregulatory activities. all of these non-iron-dependent activities are mediated by the highly charged n terminus of lactoferrin. in this study we characterized a lys/arg polymorphism at position 29 in the n-te ...	2003	14573629
genomic organization and molecular characterization of sm1, a temperate bacteriophage of streptococcus mitis.	the direct binding of streptococcus mitis to human platelets is mediated in part by two proteins (pbla and pblb) encoded by a lysogenic bacteriophage (sm1). since sm1 is the first prophage of s. mitis that has been identified and because of the possible role of these phage-encoded proteins in virulence, we sought to characterize sm1 in greater detail. sequencing of the sm1 genome revealed that it consisted of 34,692 bp, with an overall g+c content of 39 mol%. fifty-six genes encoding proteins of ...	2003	14617660
identification of early microbial colonizers in human dental biofilm.	to elucidate the first colonizers within in vivo dental biofilm and to establish potential population shifts that occur during the early phases of biofilm formation.	2004	15546422
hematogenous infection of the human temporomandibular joint.	objective this study was designed to discover the relationship between bacteremia and the presence of specific bacterial species in the synovial fluid of the human temporomandibular joint (tmj). study design sixteen volunteers (female to male, 1:2.2; average age, 30.00 +/- 9.93 years) who received operations via intraoral incision participated in this study. samples from the blood and tmj synovial fluid of the patients were taken preoperatively and postoperatively and analyzed by pcr assays with ...	2005	15660076
molecular analysis of colonized bacteria in a human newborn infant gut.	the complex ecosystem of intestinal microflora is estimated to harbor approximately 400 different microbial species, mostly bacteria. however, studies on bacterial colonization have mostly been based on culturing methods, which only detect a small fraction of the whole microbiotic ecosystem of the gut. to clarify the initial acquisition and subsequent colonization of bacteria in an infant within the few days after birth, phylogenetic analysis was performed using 16s rdna sequences from the dna i ...	2005	16145549
the vital status of human buccal epithelial cells and the bacteria associated with them.	we have shown that buccal epithelial cells (bec) from humans can contain a polymicrobial intracellular flora. members of that flora can induce proinflammatory responses. however, our subjects all had healthy oral mucosa. this might reflect tolerance of bacterial invasion by live bec. alternatively, inflammation might not occur if invaded cells were mostly dead, and thus unable to mount a response. this study addressed that issue, by determining the vital status of bec and the bacteria associated ...	2006	16239000
horizontal transfer of the immunoglobulin a1 protease gene (iga) from streptococcus to gemella haemolysans.	bacterial iga1 proteases share the ability to cleave human iga1 at the hinge region. nature has developed this trait along at least five independent evolutionary lineages. to obtain further insight into the phylogeny and function of iga1 proteases, the nucleotide sequence of the iga gene that encodes the iga1 protease was determined from two streptococcus mitis strains and one gemella haemolysans strain. heterologous expression in escherichia coli confirmed that the genes encode human iga1-cleav ...	2006	16804190
assessment of the bacterial diversity of human colostrum and screening of staphylococcal and enterococcal populations for potential virulence factors.	in contrast to breast milk, little is known about the bacterial composition of human colostrum. the objective of this work was to analyze the bacterial diversity of colostrum obtained from healthy women and to characterize the dominant bacterial species for the presence of possible virulence factors. samples of colostrum obtained from 36 healthy women were inoculated into different culture media. several isolates from each medium were selected and identified. staphylococcal and enterococcal isol ...	2008	18845249
an alternative surgical approach for aortic infective endocarditis: vegetectomy.	we describe a case of successful vegetectomy of the aortic valves for early infective endocarditis. an aortic vegetectomy was performed as an alternative to valve replacement for a 54-year-old man with three vegetations and mild regurgitation in aortic valve due to infective endocarditis. postoperative clinical course was without signs of recurrent infection after follow-up of 19 months, and transesophageal echocardiography demonstrated aortic valve competence. we would suggest that vegetectomy ...	2009	19328708
infectious complications in patients receiving autologous cd34-selected hematopoietic stem cell transplantation for severe autoimmune diseases.	long-term analysis of infectious complication after high-dose immunosuppressive therapy with cd34-selected autologous hematopoietic stem cell transplantation for patients with severe autoimmune diseases (ad) was performed. theoretically, cd34 selection can reduce the risk of reinfusion of autoreactive lymphocytes. however, it is also associated with a significant reduction in t cells, natural killer cells, and monocytes, which in turn may compromise immune reconstitution, thereby increasing the ...	2009	19453993
comparative genomic analysis of ten streptococcus pneumoniae temperate bacteriophages.	streptococcus pneumoniae is an important human pathogen that often carries temperate bacteriophages. as part of a program to characterize the genetic makeup of prophages associated with clinical strains and to assess the potential roles that they play in the biology and pathogenesis in their host, we performed comparative genomic analysis of 10 temperate pneumococcal phages. all of the genomes are organized into five major gene clusters: lysogeny, replication, packaging, morphogenesis, and lysis ...	2009	19502408
the immune response of oral epithelial cells induced by single-species and complex naturally formed biofilms.	in the oral cavity, the surfaces are constantly exposed to a complex variety of microorganisms organized in biofilms. as part of a sophisticated local immune response, gingival epithelial cells (gecs) express antimicrobial peptides, such as human beta-defensin-2 (hbd-2), ribonuclease 7 (rnaase-7), and psoriasin (pso), and pro-inflammatory mediators, such as interleukin-8 (il-8) and 5-lipoxygenase (5-lo). the aim of the present study was to test whether gecs show a differential immune response to ...	2009	19572896
microbial interactions influence inflammatory host cell responses.	the inflammatory response plays an important role in the tissue destruction associated with periodontitis. bacterial species can regulate the inflammatory responses of host cells, triggered by pathogens. it was hypothesized that, in the field of oral microbiology/immunology, such effects of bacterial interactions on inflammatory host cell responses might also be present. in this study, the effects of beneficial, commensal, and pathogenic species on aggregatibacter actinomycetemcomitans-induced i ...	2009	19828891
photodynamic inactivation of escherichia coli and streptococcus mitis by cationic zinc(ii) phthalocyanines in media with blood derivatives.	the photodynamic inactivation (pdi) of escherichia coli and streptococcus mitis sensitized by cationic phthalocyanines was studied in different media containing blood derivatives. first, the activity of zinc(ii) tetramethyltetrapyridino[3,4-b:3',4'-g:3'',4''-l:3''',4'''-q]porphyrazinium (znapc4+), zinc(ii) 2,9,16,23-tetrakis[4-(n-methylpyridyloxy)]phthalocyanine (znppc4+) and zinc(ii) 2,9,16,23-tetrakis[2-(n,n,n-trimethylamino)ethoxy]phthalocyanine (znepc4+) were compared to photoinactivate thes ...	2010	20153568
amplification of minute amounts of oral bacterial dna for real-time quantitative pcr analysis.	high-throughput technologies for typing caries or health-associated bacterial populations including pcr, dna microarrays and next-generation sequencing techniques require significant amounts of bacterial dna. in clinical settings, the amount of sampled dna is often limited and amplification is therefore essential. protocols should be able to reproducibly amplify sequences in order to maintain initial sequence ratios and should not bias the representation of particular dna sequence types.	2010	20881394
streptococcus mitis: walking the line between commensalism and pathogenesis.	streptococcus mitis is a viridans streptococcus and a normal commensal of the human oropharynx. however, s. mitis can escape from this niche and cause a variety of infectious complications including infective endocarditis, bacteraemia and septicaemia. it uses a variety of strategies to effectively colonize the human oropharynx. these include expression of adhesins, immunoglobulin a proteases and toxins, and modulation of the host immune system. these various colonization factors allow s. mitis t ...	2011	21375700
streptococcus lactarius sp. nov., isolated from breast milk of healthy women.	three strains of a hitherto-unknown, gram-stain-positive coccus were recovered from the milk of three non-related healthy women. the isolates shared 99 % 16s rrna gene sequence similarity with sequences from uncultured members of the lactobacillales and streptococcus. the closest sequence corresponding to a defined species was that of streptococcus peroris gtc 848(t), with a similarity of 98 %. a partial sequence (488 bp) of the tuf gene also showed 97 % similarity with that of s. peroris ccug 3 ...	2011	20511454
metagenomic detection of phage-encoded platelet-binding factors in the human oral cavity.	the human oropharynx is a reservoir for many potential pathogens, including streptococcal species that cause endocarditis. although oropharyngeal microbes have been well described, viral communities are essentially uncharacterized. we conducted a metagenomic study to determine the composition of oropharyngeal dna viral communities (both phage and eukaryotic viruses) in healthy individuals and to evaluate oropharyngeal swabs as a rapid method for viral detection. viral dna was extracted from 19 p ...	2011	20547834