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sarcocystis species in red deer revisited: with a re-description of two known species as sarcocystis elongata n. sp. and sarcocystis truncata n. sp. based on mitochondrial cox1 sequences.in a previous investigation, five sarcocystis species were described from norwegian red deer and believed to be conspecific with species occurring in either reindeer or moose based on sarcocyst morphology and nucleotide sequences of the nuclear ribosomal dna unit. the aim of the present study was to characterize numerous isolates of these sarcocyst types at the mitochondrial cytochrome c oxidase subunit i gene (cox1) in order to corroborate or refute previous species designations of sarcocystis ...201424230915
first reports of pseudorabies and winter ticks (dermacentor albipictus) associated with an emerging feral swine (sus scrofa) population in new hampshire.the expansion of feral swine (sus scrofa) populations into new geographic regions is of concern not only due to increased range but also because they carry diseases and parasites that pose a threat to humans, livestock, and wildlife into new areas. recently, emerging feral swine populations have been reported in the northeastern us and due to their adaptive nature will likely continue to spread. during 2009-2012, 49 feral swine were removed from three counties in new hampshire. of these, serum s ...201424171577
climate and habitat influence prevalence of meningeal worm infection in north dakota, usa.the meningeal worm (parelaphostrongylus tenuis) is a parasite of white-tailed deer (odocoileus virginianus) and is also a significant pathogen of moose (alces alces) and other ungulates. changes in climate or habitat may facilitate range expansion or increase the prevalence of meningeal worm infection in white-tailed deer, resulting in increased exposure to susceptible ungulates. we examined 3,730 white-tailed deer during 2002-05 to determine the prevalence and range of meningeal worm infection ...201525973622
high prevalence of hepatitis e virus in swedish moose--a phylogenetic characterization and comparison of the virus from different regions.hepatitis e virus (hev) infects a range of species, including humans, pigs, wild boars and deer. zoonotic transmission may contribute to the high hev seroprevalence in the human population of many countries. a novel divergent hev from moose (alces alces) in sweden was recently identified by partial genome sequencing. since only one strain was found, its classification within the hev family, prevalence in moose and zoonotic potential was unclear. we therefore investigated samples from 231 moose i ...201525906163
meningoencephalitis associated with disseminated sarcocystosis in a free-ranging moose (alces alces) calf.a wild moose (alces alces) calf was presented for necropsy due to severe neurologic signs. histopathologic examination revealed multisystemic inflammation with intralesional mature and immature schizonts. schizonts in the brain reacted positively to sarcocystis spp. polyclonal antibodies. gene sequencing of pcr-amplified dna identified the species as sarcocystis alceslatrans.201526246636
hybrids of shigatoxigenic and enterotoxigenic escherichia coli (stec/etec) among human and animal isolates in finland.diarrhoeagenic escherichia coli (dec) cause serious foodborne infections in humans. total of 450 shigatoxigenic e. coli (stec) strains isolated from humans, animals and environment in finland were examined by multiplex pcr targeting the virulence genes of various dec pathogroups simultaneously. one per cent (3/291) of the human stec and 14% (22/159) of the animal and environmental stec had genes typically present in enterotoxigenic e. coli (etec). the strains possessed genes encoding both shiga ...201525571907
an expanding population of the giant liver fluke (fascioloides magna) in elk (cervus canadensis) and other ungulates in canada.giant liver fluke (fascioloides magna) populations readily expand under suitable conditions. although extirpated from the eastern slopes of the canadian rocky mountains in the early 1960s, the fluke reappeared following natural spread through mountain passes from british columbia. herein, we assessed epizootiology of the fluke population two decades later. between 1984 and 1991, 534 ungulates, including 381 elk (cervus canadensis), 68 mule deer (odocoileus hemionus hemionus), 54 white-tailed dee ...201525647594
landscape influence on spatial patterns of meningeal worm and liver fluke infection in white-tailed deer.parasites that primarily infect white-tailed deer (odocoileus virginianus), such as liver flukes (fascioloides magna) and meningeal worm (parelaphostrongylus tenuis), can cause morbidity and mortality when incidentally infecting moose (alces alces). ecological factors are expected to influence spatial variation in infection risk by affecting the survival of free-living life stages outside the host and the abundance of intermediate gastropod hosts. here, we investigate how ecology influenced the ...201525498206
necropsy findings in 62 opportunistically collected free-ranging moose (alces alces) from minnesota, usa (2003-13).the minnesota, us moose population has declined dramatically since the 1990s. all 54 carcasses of moose that died of unknown cause or were euthanized by gun shot by tribal or department of natural resources personnel because of perceived signs of illness between 2003 and 2013 and eight carcasses of moose that died from vehicular accidents between 2009 and 2013 were submitted to the minnesota veterinary diagnostic laboratory and included in our study. the majority of the animals were underweight ...201525390764
prevalence and molecular typing of giardia duodenalis in wildlife from eastern poland.faecal samples from 162 wild animals were collected from 32 distinct sites of łęczyńsko-włodawskie lakeland (eastern poland). the presence of giardia duodenalis (stiles, 1902) was assessed by a direct fluorescence assay (dfa) and by polymerase chain reaction (pcr) and sequencing of a fragment of the beta-giardin gene. dfa showed the presence of cysts of g. duodenalis in 12 of 162 faecal samples (7%), namely in four wild boars (15%), four foxes (19%), two roe deer (4%), and two wolves (29%). pcr ...201526278650
an autochthonous case of cystic echinococcosis in finland, 2015.we report a case of pulmonary cystic echinococcosis in a child from eastern finland with no history of travelling abroad. the cyst was surgically removed and the organism molecularly identified as echinococcus canadensis genotype g10. this parasite is maintained in eastern finland in a sylvatic life cycle involving wolves and moose; in the present case, the infection was presumably transmitted by hunting dogs.201526538367
echinococcus canadensis transmission in the north.the echinococcus granulosus complex (eg) is the causative agent of cystic echinococcosis (ce). northern cervid echinococcus was previously suggested to be the ancestor of the entire eg. during the last century, it was regarded to have three (or four) different, but often overlapping, transmission cycles in the circumpolar north: the original wolf-wild cervid (reindeer or elk)-cycle; the semi-synanthropic cycle involving sled and hunting dogs and wild cervids; and the synanthropic cycle involving ...201526264249
the first report of human-derived g10 genotype of echinococcus canadensis in china and possible sources and routes of transmission.cystic echinococcosis (ce) is one of the most important parasitic zoonoses. 10 distinct genotypes, designated g1-g10 genotypes of echinococcus granulosus sensu lato (s.l.), have been split into 4 species: echinococcus granulosus sensu stricto (s.s.) (g1-g3), echinococcus equinus (g4), echinococcus ortleppi (g5) and echinococcus canadensis (g6-g10); echinococcus felidis has also been suggested as a sister taxon of e. granulosus s.s. recently. four genotypes belonging to two species (g1 and g3 gen ...201525967082
considering treatment of male genital schistosomiasis as a tool for future hiv prevention: a systematic review.male genital schistosomiasis (mgs) is a neglected manifestation of schistosoma haematobium infection with ignored implications on reproductive health and a differential diagnosis to sexually transmitted infections in endemic regions. mgs may have associations with hiv transmission and acquisition, and treatment could be a neglected chance of hiv prevention. this review summarizes current knowledge on epidemiology, clinical manifestations, diagnosis and treatment of mgs as a hypothesized risk fac ...201526298443
a lymphatic dwelling filarioid nematode, rumenfilaria andersoni (filarioidea; splendidofilariinae), is an emerging parasite in finnish cervids.recent studies revealed expansion of filarioid nematodes into northern finland. in addition to setaria tundra, an abundant filarioid, rumenfilaria andersoni, was found inhabiting the lymphatic vessels of reindeer. our study explores the dynamics of the rapid geographic expansion of r. andersoni, defining prevalence and density of microfilariae among 4 new cervid host species in finland while developing a context for host-parasite ecology in fennoscandia and more broadly in the arctic and boreal ...201525884201
fibrolytic bacteria isolated from the rumen of north american moose (alces alces) and their use as a probiotic in neonatal lambs.fibrolytic bacteria were isolated from the rumen of north american moose (alces alces), which eat a high-fiber diet of woody browse. it was hypothesized that fibrolytic bacteria isolated from the moose rumen could be used as probiotics to improve fiber degradation and animal production. thirty-one isolates (bacillus, n = 26; paenibacillus, n = 1; and staphylococcus, n = 4) were cultured from moose rumen digesta samples collected in vermont. using sanger sequencing of the 16s rrna gene, culturing ...201526716685
characterization of moose intestinal glycosphingolipids.as a part of a systematic investigation of the species-specific expression of glycosphingolipids, acid and non-acid glycosphingolipids were isolated from three small intestines and one large intestine of the moose (alces alces). the glycosphingolipids were characterized by binding of monoclonal antibodies, lectins and bacteria in chromatogram binding assays, and by mass spectrometry. the non-acid fractions were complex mixtures, and all had glycosphingolipids belonging to the lacto- and neolacto ...201526104834
testing predator-prey theory using broad-scale manipulations and independent validation.a robust test of ecological theory is to gauge the predictive accuracy of general relationships parameterized from multiple systems but applied to a new area. to address this goal, we used an ecosystem-level experiment to test predator-prey theory by manipulating prey abundance to determine whether predation was density dependent, density independent, compensatory or depensatory (inversely density dependent) on prey populations. understanding the nature of predation is of primary importance in c ...201526101058
sequence analysis of bitter taste receptor gene repertoires in different ruminant species.bitter taste has been extensively studied in mammalian species and is associated with sensitivity to toxins and with food choices that avoid dangerous substances in the diet. at the molecular level, bitter compounds are sensed by bitter taste receptor proteins (t2r) present at the surface of taste receptor cells in the gustatory papillae. our work aims at exploring the phylogenetic relationships of t2r gene sequences within different ruminant species. to accomplish this goal, we gathered a colle ...201526061084
development of a multiplex pcr for identification of dictyocaulus lungworms in domestic and wild ruminants.dictyocaulus lungworms are the causative agents of parasitic bronchitis (dictyocaulosis) characterised by coughing and severe lung pathology in domestic and wild ruminants. the objective of this study was to design a simple molecular test that could detect of lungworm dna from both adult and larval lungworms and could distinguish between the most common dictyocaulus species found in cattle and in some species of wild ruminants. a multiplex pcr test with four novel primers targeting species-speci ...201526266883
high-throughput dna sequencing of the moose rumen from different geographical locations reveals a core ruminal methanogenic archaeal diversity and a differential ciliate protozoal diversity.moose rumen samples from vermont, alaska and norway were investigated for methanogenic archaeal and protozoal density using real-time pcr, and diversity using high-throughput sequencing of the 16s and 18s rrna genes. vermont moose showed the highest protozoal and methanogen densities. alaskan samples had the highest percentages of methanobrevibacter smithii, followed by the norwegian samples. one norwegian sample contained 43 % methanobrevibacter thaueri, whilst all other samples contained < 10  ...201528348818
early detection of chronic wasting disease prions in urine of pre-symptomatic deer by real-time quaking-induced conversion assay.chronic wasting disease (cwd) is a prion disease of captive and free-ranging deer (odocoileus spp), elk (cervus elaphus nelsonii) and moose (alces alces shirasi). unlike in most other prion diseases, in cwd prions are shed in urine and feces, which most likely contributes to the horizontal transmission within and between cervid species. to date, cwd ante-mortem diagnosis is only possible by immunohistochemical detection of protease resistant prion protein (prp (sc) ) in tonsil or recto-anal muco ...201523764839
a geographic cluster of malignant catarrhal fever in moose (alces alces) in norway.three cases of lethal sheep-associated malignant catarrhal fever (sa-mcf) in free-ranging moose (alces alces) were diagnosed in lesja, norway, december 2008-february 2010. the diagnosis was based on pcr identification of ovine herpesvirus 2 (ovhv-2) dna (n = 3) and typical histopathologic lesions (n = 1). to study the possibility of subclinical or latent mcf virus (mcfv) infection in this moose population and in red deer (cervus elaphus), we examined clinically normal animals sampled during hunt ...201525574807
endoparasites in a norwegian moose (alces alces) population - faunal diversity, abundance and body condition.many health surveillance programs for wild cervids do not include routine parasite screening despite evidence that gastrointestinal parasites can affect wildlife population dynamics by influencing host fecundity and survival. slaughter weights of moose in some regions of norway have been decreasing over recent decades but any role of parasites has not yet been considered. we investigated parasite faunal diversity of moose in hedmark, se norway, by faecal analysis and identification of adult abom ...201525830105
serologic and molecular prevalence of rickettsia helvetica and anaplasma phagocytophilum in wild cervids and domestic mammals in the central parts of sweden.both rickettsia helvetica and anaplasma phagocytophilum are common in ixodes ricinus ticks in sweden. knowledge is limited regarding different animal species' competence to act as reservoirs for these organism. for this reason, blood samples were collected from wild cervids (roe deer, moose) and domestic mammals (horse, cat, dog) in central sweden, and sera were tested using immunofluorescence assay to detect antibodies against spotted fever rickettsiae using rickettsia helvetica as antigen. ser ...201526378972
the first identification of a blood-sucking abomasal nematode ashworthius sidemi in cattle (bos taurus) using simple polymerase chain reaction (pcr).a simple polymerase chain reaction (pcr) test was used to identify ashworthius sidemi, a blood-sucking gastrointestinal nematode that commonly infects bison, red and roe deer, and moose in poland. the present study uses this technique to confirm the possibility of transmission of a. sidemi infection from wildlife to domestic animals, such as cattle and sheep, grazing on the same natural pastures. a 406 bp fragment of genomic a. sidemi dna was actually detected in dna isolated from larval culture ...201525981105
life stage-related differences in fatty acid composition of an obligate ectoparasite, the deer ked (lipoptena cervi)-influence of blood meals and gender.metamorphosis and diet often influence fatty acid (fa) signatures (fas) of insects. we investigated fas in a hematophagous ectoparasite, the deer ked (lipoptena cervi). deer keds shed their wings upon attachment on the host and, thus, the fas of an individual blood-fed imago/pupa in the fur of its host can be traced back to the blood fa profile of a single moose (alces alces). host blood and different life stages of deer keds were investigated for fa by gas chromatography. the fas of life stages ...201525223709
space-use behaviour of woodland caribou based on a cognitive movement model.movement patterns offer a rich source of information on animal behaviour and the ecological significance of landscape attributes. this is especially useful for species occupying remote landscapes where direct behavioural observations are limited. in this study, we fit a mechanistic model of animal cognition and movement to gps positional data of woodland caribou (rangifer tarandus caribou; gmelin 1788) collected over a wide range of ecological conditions. the model explicitly tracks individual a ...201525714592
european bison as a refugee species? evidence from isotopic data on early holocene bison and other large herbivores in northern europe.according to the refugee species concept, increasing replacement of open steppe by forest cover after the last glacial period and human pressure had together forced european bison (bison bonasus)--the largest extant terrestrial mammal of europe--into forests as a refuge habitat. the consequent decreased fitness and population density led to the gradual extinction of the species. understanding the pre-refugee ecology of the species may help its conservation management and ensure its long time sur ...201525671634
using predator-prey theory to predict outcomes of broadscale experiments to reduce apparent competition.apparent competition is an important process influencing many ecological communities. we used predator-prey theory to predict outcomes of ecosystem experiments aimed at mitigating apparent competition by reducing primary prey. simulations predicted declines in secondary prey following reductions in primary prey because predators consumed more secondary prey until predator numbers responded to reduced prey densities. losses were exacerbated by a higher carrying capacity of primary prey and a long ...201525905509
response of moose hunters to predation following wolf return in sweden.predation and hunter harvest constitute the main mortality factors affecting the size and dynamics of many exploited populations. the re-colonization by wolves (canis lupus) of the scandinavian peninsula may therefore substantially reduce hunter harvest of moose (alces alces), the main prey of wolves.201525853570
effects of climate and plant phenology on recruitment of moose at the southern extent of their range.climate plays a fundamental role in limiting the range of a species, is a key factor in the dynamics of large herbivores, and is thought to be involved in declines of moose populations in recent decades. we examined effects of climate and growing-season phenology on recruitment (8-9 months old) of young shiras moose (alces alces shirasi) over three decades, from 18 herds, across a large geographic area encompassing much of the southern extent of their range. recruitment declined in 8 of 18 herds ...201525820750
wolves adapt territory size, not pack size to local habitat quality.1. although local variation in territorial predator density is often correlated with habitat quality, the causal mechanism underlying this frequently observed association is poorly understood and could stem from facultative adjustment in either group size or territory size. 2. to test between these alternative hypotheses, we used a novel statistical framework to construct a winter population-level utilization distribution for wolves (canis lupus) in northern ontario, which we then linked to a su ...201525757794
predator-dependent functional response in wolves: from food limitation to surplus killing.the functional response of a predator describes the change in per capita kill rate to changes in prey density. this response can be influenced by predator densities, giving a predator-dependent functional response. in social carnivores which defend a territory, kill rates also depend on the individual energetic requirements of group members and their contribution to the kill rate. this study aims to provide empirical data for the functional response of wolves canis lupus to the highly managed mo ...201525109601
characteristics of spermatozoa and reproductive organs in relation to age and body weight in swedish moose (alces alces).knowledge of the reproductive biology of game species is vital for sustainable management. in moose (alces alces), research in reproductive characteristics has focused on the female, whereas there are few studies in male moose. the aim of the present study was to investigate sperm morphology and chromatin integrity (scsa), and their relationships with testicular and epididymal features, as well as temporal aspects with respect to the hunting season. in total, 143 male moose aged 1.5-11.5 years w ...201525576030
pregnancy outcomes of induced labor in women with previous cesarean section: a systematic review and meta-analysis.to systematically review the literature about maternal and neonatal outcomes following induction of labor (iol) and spontaneous labor (sl) in women with previous cesarean section (pcs).201525178187
workplace suicide prevention: a systematic review of published and unpublished activities.there are a number of published studies on workplace suicide prevention activities, and an even larger number of activities that are not reported on in academic literature. the aim of this review was to provide a systematic assessment of workplace suicide prevention activities, including short-term training activities, as well as suicide prevention strategies designed for occupational groups at risk of suicide. the search was based on meta-analysis of observational studies in epidemiology (moose ...201525256000
the effect of nasal surgery on continuous positive airway pressure device use and therapeutic treatment pressures: a systematic review and meta-analysis.the relationship between nasal surgery and its effect on continuous positive airway pressure (cpap) device therapeutic treatment pressures and cpap device use has not been previously systematically examined.201525325439
how sedentary are older people? a systematic review of the amount of sedentary behavior.sedentary behavior (sb), defined as sitting (nonexercising), reclining, and lying down (posture), or by low energy expenditure, is a public health risk independent to physical activity. the objective of this systematic literature review was to synthesize the available evidence on amount of sb reported by and measured in older adults.201525387160
solute and particle retention in a small grazing antelope, the blackbuck (antilope cervicapra).digesta retention patterns have been suggested to play a major role in ruminant diversification. two major digestion types have been proposed, termed 'cattle-type' and 'moose-type', that broadly correspond to the feeding categories of grazers and intermediate feeders on the one, and browsers on the other hand. we measured and calculated the mean retention time (mrt) of a solute and a particle (<2 mm) marker in the gastrointestinal tract (git) and the reticulorumen (rr) of a small grazer, the ind ...201525490292
twenty-five years of fetoscopic laser coagulation in twin-twin transfusion syndrome: a systematic review.the aim of this study was to assess the perinatal outcome of pregnancies with twin-twin transfusion syndrome (ttts) treated with laser therapy over the past 25 years, and in relation to different techniques used in this time period.201526278319
effect of roadside vegetation cutting on moose browsing.moose (alces americanus ) vehicle collisions (mvcs) are an issue throughout the distribution of moose. many mitigation strategies have been tested and implemented to reduce the number of mvcs, but there have been few empirical analyses of the effectiveness of roadside vegetation cutting. the goal of this study was to determine if roadside vegetation cutting attracted moose into roadside areas to browse on the vegetation regrowth. we hypothesized that moose would be attracted to roadside areas wi ...201526244576
a spatial theory for characterizing predator-multiprey interactions in heterogeneous landscapes.trophic interactions in multiprey systems can be largely determined by prey distributions. yet, classic predator-prey models assume spatially homogeneous interactions between predators and prey. we developed a spatially informed theory that predicts how habitat heterogeneity alters the landscape-scale distribution of mortality risk of prey from predation, and hence the nature of predator interactions in multiprey systems. the theoretical model is a spatially explicit, multiprey functional respon ...201526224710
lead exposure through consumption of big game meat in quebec, canada: risk assessment and perception.game meat from animals killed by lead ammunition may expose consumers to lead. we assessed the risk related to lead intake from meat consumption of white-tailed deer and moose killed by lead ammunition and documented the perception of hunters and butchers regarding this potential contamination. information on cervid meat consumption and risk perception were collected using a mailed self-administrated questionnaire which was addressed to a random sample of quebec hunters. in parallel, 72 samples ...201526161681
type 2 diabetes in patients with major depressive disorder: a meta-analysis of prevalence estimates and predictors.patients with depression may be at increased risk of type 2 diabetes mellitus (t2dm), which is a risk factor for cardiovascular diseases and premature mortality. we aimed to clarify the prevalence and predictors of t2dm in patients with major depressive disorder (mdd) and where possible compare the prevalence of t2dm in those with mdd versus general population controls.201526114259
diabetic nephropathy in africa: a systematic review.to determine the prevalence and incidence of diabetic nephropathy in africa.201526069725
incidence of lower extremity amputation in the diabetic compared to the non-diabetic population: a systematic review protocol.diabetic individuals have a largely increased risk of lower extremity amputation (lea) compared with non-diabetic patients. prior systematic reviews of incidence of lea have some limitations with respect to lack of consensus in the definition of lea, level of lea (all, major, minor), and definition of source population (general population or population with diabetes at risk). the purpose of our review is to evaluate the incidence of lea in the diabetic population and its differences with regard ...201526001384
effectiveness of interventions to improve patient handover in surgery: a systematic review.handover of patient care is a critical process in the transfer of information between clinical teams and clinicians during transitions in patient care. the handover process may take many forms and is often unstructured and unstandardized, potentially resulting in error and the potential for patient harm. the joint commission has implicated such errors in up to 80% of sentinel events and has published guidelines (using an acronym termed share) for the development of intervention tools for handove ...201525999255
differences in symptom reporting between males and females at baseline and after a sports-related concussion: a systematic review and meta-analysis.concussion literature and treatment guidelines are inconclusive regarding the role of sex in symptom reporting at baseline and post-concussion. although empirical evidence is lacking, it is generally regarded that females have a more severe symptomatic presentation than males at all time-points on the concussion spectrum.201525971368
outcomes in the offspring of mothers with pre-diabetes during pregnancy: a protocol for a systematic review.despite the increasing prevalence of pre-diabetes worldwide, there is insufficient literature on the impact of gestational pre-diabetes on offspring outcomes. the objective of this systematic review is to determine the risk of developing adverse outcomes for the offspring in women with pre-diabetes compared to women with normal glucose levels and women with gestational diabetes mellitus.201525957870
digesta retention patterns of solute and different-sized particles in camelids compared with ruminants and other foregut fermenters.the mean retention times (mrt) of solute or particles in the gastrointestinal tract and the forestomach (fs) are crucial determinants of digestive physiology in herbivores. besides ruminants, camelids are the only herbivores that have evolved rumination as an obligatory physiological process consisting of repeated mastication of large food particles, which requires a particle sorting mechanism in the fs. differences between camelids and ruminants have hardly been investigated so far. in this stu ...201525921796
transarterial embolization of angiomyolipoma: a systematic review.transarterial embolization is increasingly used in the management of renal angiomyolipoma. the level of evidence establishing the safety and efficacy of transarterial embolization has not increased in parallel.201525916674
the effects of morbid obesity on maternal and neonatal health outcomes: a systematic review and meta-analyses.morbidly obese (class iii, body mass index [bmi] ≥ 40 kg m(-2)) women constitute 8% of reproductive-aged women and are an increasing proportion; however, their pregnancy risks have not yet been well understood. hence, we performed meta-analyses following the moose (meta-analysis of observational studies in epidemiology) guideline, searching medline and embase from their inceptions. to examine graded relationships, we compared class iii obesity to class i and i/ii, and separately to normal weight ...201525912896
evaluation of the p53 arg72pro polymorphism and its association with cancer risk: a huge review and meta-analysis.codon 72 is a hotspot of polymorphisms in the tp53 gene, which encodes a hub protein in the protein-protein interaction network of p53. it is thus a central player in the apoptotic pathway, preventing cancer. a large number of articles have been published exploring its association with an increased susceptibility to most common cancers. however, these studies have produced inconclusive results, which may be due to their small sample sizes or study designs. to comprehensively evaluate the potenti ...201525882871
prevalence and incidence of dyslipidaemia among adults in africa: a systematic review and meta-analysis protocol.cardiovascular disease (cvd) is the leading cause of death globally and disproportionately affects low-income and middle-income countries. dyslipidaemia is an important modifiable risk factor for cvd. there are important knowledge gaps regarding the population levels of lipid variables and frequency of non-optimal levels in populations within africa. we propose to conduct a systematic review to determine the prevalence and occurrence of dyslipidaemia in adult populations within countries in afri ...201525783427
development of an adaptive monitoring framework for long-term programs: an example using indicators of fish health.detecting unwanted changes associated with localized human activities in aquatic ecosystems requires defining the value of an indicator expected at a site in the absence of development. ideally, adequate and comparable baseline data will be collected at an exposure location before that development, but this is rarely done. instead, comparisons are made using various designs to overcome the inadequate or missing baseline data. commonly these comparisons are done over short periods, using informat ...201525781001
the effects of maternal depression, anxiety, and perceived stress during pregnancy on preterm birth: a systematic review.experiencing psychological distress such as depression, anxiety, and/or perceived stress during pregnancy may increase the risk for adverse birth outcomes, including preterm birth. clarifying the association between exposure and outcome may improve the understanding of risk factors for prematurity and guide future clinical and research practices.201525765470
cancer risk in dermatomyositis: a meta-analysis of cohort studies.an association between dermatomyositis (dm) and cancer has been reported since 1916; however, estimates of the associated risk vary widely. for cost-effectiveness reasons it might be important to elucidate the degree of overall cancer risk in dm.201525721032
prevalence of chagas disease in latin-american migrants living in europe: a systematic review and meta-analysis.few studies have assessed the burden of chagas disease in non-endemic countries and most of them are based on prevalence estimates from latin american (la) countries that likely differ from the prevalence in migrants living in europe. the aim of this study was to systematically review the existing data informing current understanding of the prevalence of chagas disease in la migrants living in european countries.201525680190
micrornas as prognostic molecular signatures in human head and neck squamous cell carcinoma: a systematic review and meta-analysis.the aim of this study was to systematically review the articles investigating the prognostic value of different micrornas (mirs) in human head and neck squamous cell carcinoma (hnscc). following the guidelines of the meta-analysis of observational studies in epidemiology group (moose), we performed a broad and sensitive search on online databases to identify the studies that examined associations between different mirs expression and hnscc prognosis. in this study, we considered clinical endpoin ...201525677760
dose modifications of anti-tnf drugs in rheumatoid arthritis patients under real-world settings: a systematic review.anti-tnf dose modifications in rheumatoid arthritis have implications on healthcare resource utilization. the objective was to systematically review the dose modifications, both escalations and reductions, of currently available anti-tnf drugs (adalimumab, certolizumab, etanercept, golimumab and infliximab) in the real-world setting. we performed a systematic literature search of medline, isi web of science, embase, indice médico español databases and american college of rheumatology and europea ...201525638015
the place of corticosteroids in migraine attack management: a 65-year systematic review with pooled analysis and critical appraisal.headaches recur in up to 87% of migraine patients visiting the emergency department (ed), making ed recidivism a management challenge. we aimed herein to determine the role of corticosteroids in the acute management of migraine in the ed and outpatient care.201525576463
shiver me titin! elucidating titin's role in shivering thermogenesis.shivering frequency scales predictably with body mass and is 10 times higher in a mouse than a moose. the link between shivering frequency and body mass may lie in the tuning of muscle elastic properties. titin functions as a muscle 'spring', so shivering frequency may be linked to titin's structure. the muscular dystrophy with myositis (mdm) mouse is characterized by a deletion in titin's n2a region. mice that are homozygous for the mdm mutation have a lower body mass, stiffer gait and reduced ...201525573826
prevalence of type 2 diabetes in nepal: a systematic review and meta-analysis from 2000 to 2014.background understanding the prevalence of type 2 diabetes in nepal can help in planning for health services and recognising risk factors. this review aims to systematically identify and collate studies describing the prevalence of type 2 diabetes, to summarise the findings, and to explore selected factors that may influence prevalence estimates. design this systematic review was conducted in adherence to the moose guidelines for meta-analysis and systematic reviews of observational studies. med ...201528156709
dna left on browsed twigs uncovers bite-scale resource use patterns in european ungulates.fine-scale resource use by large herbivores is often difficult to quantify directly. this is particularly true for browsing ungulates due to the challenges in observing shy subjects in forested environments of low visibility. as a consequence we know relatively little about resource use by diverse browsing ungulates. when browsing, ungulates leave behind saliva on the browsed twig that includes their dna, which can be used to identify the species that was responsible for browsing the twig. we us ...201525543852
routes for early enteral nutrition after esophagectomy. a systematic review.early enteral feeding following surgery can be given orally, via a jejunostomy or via a nasojejunal tube. however, the best feeding route following esophagectomy is unclear.201525131601
effects of transplantation of olfactory ensheathing cells in chronic spinal cord injury: a systematic review and meta-analysis.the debate on the effects and outcome of olfactory ensheathing cell (oec) transplantation for the treatment of spinal cord injury (sci) has remained unresolved for nearly 20 years. this study aimed to evaluate the safety and efficacy of oec transplantation in chronic sci patients.201525001890
prevalence of cannabis lifetime use in iranian high school and college students: a systematic review, meta-analyses, and meta-regression.cannabis is the most widely used substance in the world. this study aimed to estimate the prevalence of cannabis lifetime use (clu) in high school and college students of iran and also to determine factors related to changes in prevalence. a systematic review of literature on cannabis use in iran was conducted according to moose guideline. domestic scientific databases, pubmed/medline, isi web of knowledge, and google scholar, relevant reference lists, and relevant journals were searched up to a ...201525147097
neurodevelopmental delay with critical congenital heart disease is mainly from prenatal injury not infant cardiac surgery: current evidence based on a meta-analysis of functional magnetic resonance imaging.no consensus has been reached regarding whether brain injury related to congenital heart disease (chd) is caused by infant cardiac surgery and/or prenatal injury resulting from the chd. we performed this meta-analysis to identify the likely cause of neurodevelopmental delay in chd patients.201524913334
molecular detection of bartonella spp. in deer ked pupae, adult keds and moose blood in finland.the deer ked (lipoptena cervi) is a haematophagous ectoparasite of cervids that harbours haemotrophic bartonella. a prerequisite for the vector competence of the deer ked is the vertical transmission of the pathogen from the mother to its progeny and transstadial transmission from pupa to winged adult. we screened 1154 pupae and 59 pools of winged adult deer keds from different areas in finland for bartonella dna using pcr. altogether 13 pupa samples and one winged adult deer ked were positive f ...201524901607
new applications of adaptogens to reduce radiation side effects.one of the live medical issues today is to find medication to prevent adverse effects of ionizing radiation on the immune and hematopoietic systems. in yakutia where in most of its regions the overall environmental situation is getting worse due to the development of natural deposits including radioactive deposits, this problem remains vital. the purpose of this work is to study radioprotective properties of adaptogens in the case of the hematopoietic system under irradiation. the studies were c ...201526887117
prognostic significance of cd44v6 expression in osteosarcoma: a meta-analysis.numerous individual studies evaluating the relationship between cd44v6 over-expression and prognostic impact in patients with osteosarcoma (os) have yielded in conclusive results. this meta-analysis aimed to determine the value of cell adhesion molecule cd44v6 in prognosis of os by conducting a systematic review and meta-analysis. a comprehensive search was conducted using pubmed (medline), embase, isi web of knowledge, springer, the cochrane library, scopus, biomed central, sciencedirect, wanfa ...201526697855
epidemiology, quality and reporting characteristics of meta-analyses of observational studies published in chinese journals.the aim of this study was to examine the epidemiological and reporting characteristics as well as the methodological quality of meta-analyses (mas) of observational studies published in chinese journals.201526644119
prevalence of type 2 diabetes in nepal: a systematic review and meta-analysis from 2000 to 2014.understanding the prevalence of type 2 diabetes in nepal can help in planning for health services and recognising risk factors. this review aims to systematically identify and collate studies describing the prevalence of type 2 diabetes, to summarise the findings, and to explore selected factors that may influence prevalence estimates.201526613684
the importance of community consultation and social support in adhering to an obesity reduction program: results from the healthy weights initiative.few community-based obesity reduction programs have been evaluated. after 153 community consultations, the city of moose jaw, sk, canada, decided to initiate a free comprehensive program. the initiative included 71 letters of support from the mayor, every family physician, cardiologist, and internist in the city, and every relevant community group including the heart and stroke foundation, the canadian cancer society, and the public health agency of canada.201526508843
wildlife in the cloud: a new approach for engaging stakeholders in wildlife management.research in wildlife management increasingly relies on quantitative population models. however, a remaining challenge is to have end-users, who are often alienated by mathematics, benefiting from this research. i propose a new approach, 'wildlife in the cloud,' to enable active learning by practitioners from cloud-based ecological models whose complexity remains invisible to the user. i argue that this concept carries the potential to overcome limitations of desktop-based software and allows new ...201526508343
[wild mammals of the grand duchy of lithuania in the works of jean-emmanuel gilibert].among the many topics of lively scientific work that jean emmanuel gilibert (1741-1814) conducted in grodno and vilnius, an important place is occupied by his observations of wild mammals. royal patronage and care from antoni tyzenhauz, treasurer of the grand duchy of lithuania and the governor of grodno, allowed gilibert to keep and observe wild fauna captured by royal services in royal forests, including białowieża primeval forest. such was an origin of a female bison kept by gilibert in grodn ...201526445747
hypertension prevalence, incidence and risk factors among children and adolescents in africa: a systematic review and meta-analysis protocol.the african adult population is facing a growing epidemic of hypertension. establishment of accurate epidemiological data on hypertension in african children and adolescents may have important implications for hypertension preventive strategies in africa.201526373403
polycyclic aromatic hydrocarbons in caribou, moose, and wolf scat samples from three areas of the alberta oil sands.impacts of toxic substances from oil production in the alberta oil sands (aos), such as polycyclic aromatic hydrocarbons (pahs), have been widely debated. studies have been largely restricted to exposures from surface mining in aquatic species. we measured pahs in woodland caribou (rangifer tarandus caribou), moose (alces americanus), and grey wolf (canis lupus) across three areas that varied in magnitude of in situ oil production. our results suggest a distinction of pah level and source profil ...201526284348
constipation preceding parkinson's disease: a systematic review and meta-analysis.to systematically review published literature to estimate the magnitude of association between premorbid constipation and later diagnosis of parkinson's disease.201626345189
alcohol and mortality after moderate to severe traumatic brain injury: a meta-analysis of observational studies.object experimental studies have shown numerous neuroprotective properties of alcohol ("ethanol") after tbi, but clinical studies have provided conflicting results. the authors aimed to assess the relationship between positive blood alcohol concentration (bac) on hospital admission and mortality after moderate to severe traumatic brain injury (tbi). methods the authors searched 8 databases for observational studies reported between january 1, 1990, and october 7, 2013, and investigated the effec ...201626495950
driving behaviour responses to a moose encounter, automatic speed camera, wildlife warning sign and radio message determined in a factorial simulator study.in a driving simulator study, driving behaviour responses (speed and deceleration) to encountering a moose, automatic speed camera, wildlife warning sign and radio message, with or without a wildlife fence and in dense forest or open landscape, were analysed. the study consisted of a factorial experiment that examined responses to factors singly and in combination over 9-km road stretches driven eight times by 25 participants (10 men, 15 women). the aims were to: determine the most effective ani ...201626600095
potential vertical transmission of winter ticks (dermacentor albipictus) from moose (alces americanus) dams to neonates.north american moose (alces americanus) frequently become infested with winter ticks (dermacentor albipictus). during capture of neonatal moose in northeastern minnesota, us, in may-june 2013 and 2014, we recovered adult ticks from neonates, presumably vertically transferred from dams, heretofore, not documented. infestations on neonates may have population-level implications.201626555113
coffee consumption and melanoma: a systematic review and meta-analysis of observational studies.laboratory and animals studies have suggested a possible protective effect of coffee consumption on the development of melanoma. however, the results of epidemiological studies investigating this association have been inconclusive.201626547919
novel wildlife in the arctic: the influence of changing riparian ecosystems and shrub habitat expansion on snowshoe hares.warming during the 20th century has changed the arctic landscape, including aspects of the hydrology, vegetation, permafrost, and glaciers, but effects on wildlife have been difficult to detect. the primary aim of this study is to examine the physical and biological processes contributing to the expanded riparian habitat and range of snowshoe hares (lepus americanus) in northern alaska. we explore linkages between components of the riparian ecosystem in arctic alaska since the 1960s, including s ...201626527375
macroscopic digestive tract anatomy of two small antelopes, the blackbuck (antilope cervicapra) and the arabian sand gazelle (gazella subgutturosa marica).the digestive tract anatomy of 14 blackbucks (antilope cervicapra) and seven arabian sand gazelles (gazella subgutturosa marica) was quantified by dimensions, area and weight. data from the two small-sized antilopinae were evaluated against a larger comparative data set from other ruminants classified as having either a 'cattle-type' or 'moose-type' digestive system. the digestive anatomy of the blackbuck resembled that of 'cattle-type' ruminants, which corresponds to their feeding ecology and p ...201626514913
systematic review of drug eluting balloon angioplasty for arteriovenous haemodialysis access stenosis.native or prosthetic arteriovenous (av) fistulas are preferred for permanent haemodialysis (hd) access. these are marked with circuit steno-occlusive disease leading to dysfunction or even failure. late failure rates have been reported as high as 50%. standard angioplasty balloons are an established percutaneous intervention for hd access stenosis. reported restenosis rates remain high and practice guidelines recommend a wide 6-month primary patency (pp) of at least 50% for any intervention. neo ...201626847736
animal welfare from mouse to moose--implementing the principles of the 3rs in wildlife research.the concept of the 3rs (replacement, reduction, and refinement) was originally developed for improving laboratory animal welfare and is well known in biomedical and toxicologic research. the 3rs have so far gained little attention in wildlife research, and there could be several reasons for this. first, researchers may prioritize the welfare of populations and ecosystems over the welfare of individual animals. the effects of research on individual animals can, however, impact welfare and researc ...201626845301
correlation between nitrogen dioxide as an air pollution indicator and breast cancer: a systematic review and meta- analysis.the aim of this systematic review was to study the relationship between exposure to nitrogen dioxide (no2) in the ambient air and breast cancer incidence.201626838249
is obesity in psoriatic arthritis associated with a poorer therapeutic response and more adverse effects of treatment with an anchor drug?to assess the association between obesity, control of inflammatory activity and increased adverse effects in psoriatic arthritis (psa) with disease-modifying anti-inflammatory drugs (dmard).201626830438
ultraviolet exposure from indoor tanning devices: a systematic review.use of indoor tanning devices increases the risk of cutaneous melanoma and nonmelanoma skin cancer. indoor tanning devices have become important sources of ultraviolet (uv) exposure, both uvb and uva. this systematic review assessed uv measurements performed in indoor tanning devices related to irradiance level, wavelength distribution and similarities to natural sun. the study was performed in accordance with the moose and prisma guidelines. we searched pubmed, embase and web of science from in ...201626749382
health-related quality of life, comorbidities and mortality in pulmonary nontuberculous mycobacterial infections: a systematic review.nontuberculous mycobacterial (ntm) infections are increasing in disease frequency worldwide. this systematic review examines health-related quality of life (hrqol), comorbidities and mortality associated with pulmonary ntm disease. we searched medline, embase, cinahl, scopus life sciences, conference proceedings and google (earliest date available to february 2015) for primary studies. eligible studies compared populations with and without pulmonary ntm disease in high-income jurisdictions. we e ...201627009804
neoadjuvant radiotherapy for retroperitoneal sarcoma: a systematic review.the multi-modal treatment of retroperitoneal sarcoma has seen increased use of neoadjuvant radiation. however, its effect on local recurrence and survival remain controversial. we aimed to synthesize and evaluate the literature.201626990903
de novo transcriptome assembly of two contrasting pumpkin cultivars.cucurbita pepo (squash, pumpkin, gourd), a worldwide-cultivated vegetable of american origin, is extremely variable in fruit characteristics. however, the information associated with genes and genetic markers for pumpkin is very limited. in order to identify new genes and to develop genetic markers, we performed a transcriptome analysis (rna-seq) of two contrasting pumpkin cultivars. leaves and female flowers of cultivars, 'big moose' with large round fruits and 'munchkin' with small round fruit ...201626981408
web-based interventions for prevention and treatment of perinatal mood disorders: a systematic review.perinatal depression is strikingly common with a prevalence of 10-15%. the adverse effects of perinatal depression on maternal and child health are profound with considerable costs. despite this, few women seek medical attention. e-health, providing healthcare via the internet is an accessible and effective solution for the treatment of depression in the general population. we aimed to conduct a systematic review of web-based interventions for the prevention and treatment of mood disorders in th ...201626928898
[biomarkers in high-grade gliomas: a systematic review].biomarkers are a subcategory of clinical signs that can be measured and reproduced with precision and influence to predict outcome. tissue, cells, and fluid conform the biological process. biomarker usefulness is to determine and specify illness predisposition counting with variability and validity. process systematization can reduce operative costs. to date, four major biomarkers have been described for high-grade gliomas: 1p/19q deletion, o6-methylguanine-dna methyltransferase (mgmt) promoter ...201626927648
a systematic review of the burden of vaccine preventable pneumococcal disease in uk adults.invasive pneumococcal disease (ipd) and pneumococcal pneumonia are common and carry a significant morbidity and mortality. current strategies to prevent pneumococcal disease are under review in the united kingdom (uk). we conducted a systematic review to evaluate the burden of vaccine type adult pneumococcal disease specifically in the uk.201627169895
endoscopic resection of sinonasal malignancy: a systematic review and meta-analysis.the use of endoscopic approaches for sinonasal malignancy resection has increased, but survival data are limited secondary to disease rarity and new surgical technique. here we present a systematic review and meta-analysis of endoscopic endonasal resection of sinonasal malignancy.201627165676
effects of liver transplantation on endocrine function: a systematic review.patients with chronic liver disease (cld) often experience secondary endocrine dysfunction. therefore, because the liver plays a major role in endocrine function, liver transplantation (lt) may also be beneficial for the restoration of hormonal regulation. this systematic review collects and interprets the available literature on the effect of lt on endocrine and sexual function in adult patients. a systematic review was conducted by searching pubmed (including medline) and embase for studies pu ...201627163168
maternal psychosocial consequences of twins and multiple births following assisted and natural conception: a meta-analysis.the aim of this meta-analysis is to provide new evidence on the effects on maternal health of multiple births due to assisted reproductive technology (art). a bibliographic search was undertaken using pubmed, psycinfo, cinahl and science direct. data extraction was completed using cochrane review recommendations, and the review was performed following prisma and moose guidelines. meta-analytic data were analysed using random effects models. eight papers (2993 mothers) were included. mothers of a ...201627156004
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