Publications

neuroprotective effect of curcumin is mainly mediated by blockade of microglial cell activation.	curcumin, the major yellow pigment in turmeric (curcuma longa), is a well-documented naturally-occurring anti-oxidant with numerous pharmacological activities such as anti-inflammatory, anti-carcinogenic and anti-bacterial effects. in this study, curcumin's neuroprotective effect was carefully examined using a coculture system, based on reports that curcumin-containing plants are neuroprotective. coculturing neuronal cells and activated microglial cells enhanced dopamine-induced neuronal cell de ...	2007	18214347
influence of tetrahydrocurcumin on tail tendon collagen contents and its properties in rats with streptozotocin-nicotinamide-induced type 2 diabetes.	changes in the structural and functional properties of collagen caused by advanced glycation might be of importance for the etiology of late-stage complications in diabetics. curcumin is the most active component of turmeric. it is believed that curcumin is a potent antioxidant and anti-inflammatory agent. tetrahydrocurcumin (thc) is one of the major metabolites of curcumin, exhibiting many of the same physiological and pharmacological activities of curcumin and in some systems may exert greater ...	2007	18034669
curcumin reduces burn progression in rats.	cutaneous burns are dynamic injuries with a central zone of necrosis surrounded by a zone of ischemia. conversion of this ischemic zone to full necrosis over the days following injury is due in part to highly reactive oxygen radicals. curcumin is a component of the oriental spice turmeric that has been shown to have antioxidant and antiapoptotic properties. the authors hypothesized that treatment of burns with curcumin would reduce the conversion of the ischemic zone to full necrosis.	2007	18045885
effect of turmeric and curcumin on oxidative stress and antioxidant enzymes in streptozotocin-induced diabetic rat.	there is increasing evidence that complications related to diabetes are associated with increased oxidative stress. curcumin, an active principle of turmeric, has several biological properties, including antioxidant activity. the protective effect of curcumin and turmeric on streptozotocin (stz)-induced oxidative stress in various tissues of rats was studied.	2007	18049430
[determination of curcumol in plasma by hplc-ms/ms method and its pharmacokinetics in beagle dogs].	to establish a high performance liquid chromatography (hplc) coupled with tandem mass spectrometry quantitative detection method for the determination of curcumol, the main ingredient of zedoary turmeric oil fat emulsion, and investigate its pharmacokinetics in beagle dogs, nine healthy beagle dogs were divided into three groups, and blood samples were collected at scheduled time points after intravenous injection of 7.5, 10 and 12.5 mg x kg(-1) zedoary turmeric oil fat emulsion. the concentrati ...	2007	18050741
a pilot and feasibility study on the effects of naturopathic botanical and dietary interventions on sex steroid hormone metabolism in premenopausal women.	naturopathic physicians commonly make dietary and/or dietary supplement recommendations for breast cancer prevention. this placebo-controlled, parallel-arm, pilot study tested the effects of two naturopathic interventions over five menstrual cycles on sex steroid hormones and metabolic markers in 40 healthy premenopausal women. the intervention arms were as follows: combination botanical supplement (curcuma longa, cynara scolymus, rosmarinus officinalis, schisandra chinensis, silybum marinum, an ...	2007	17684134
a randomized, placebo-controlled, double-blind clinical trial of curcuminoids in oral lichen planus.	we studied the efficacy of curcuminoids in the treatment of oral lichen planus (olp), a chronic, mucocutaneous, immunological disease. curcuminoids are components of turmeric (curcuma longa) that have anti-inflammatory activity. turmeric has been used in ayurveda (indian traditional medicine) for centuries. a randomized, double-blind, placebo-controlled trial was conducted. in all, 100 consecutive, eligible patients with olp presenting to the oral medicine clinic at the university of california, ...	2007	17604143
standardization and stability studies of neuroprotective lipid soluble fraction obtained from curcuma longa.	the lipid soluble fraction of curcuma longa, i.e. herbal medicament (hm) was isolated from rhizome of curcuma longa by solvent extraction method. the identification of chemical constituent present in hm was done with gc, gc-ms. the standardization of hm was done using hplc method on the basis of three-marker compound isolated, i.e. ar-turmerone, turmerone and curlone. the effect of temperature, ph and light on stability of marker compounds of hm was studied. the composition of marker compound in ...	2007	17590557
protection from acute and chronic lung diseases by curcumin.	the aim of this review has been to describe the current state of the therapeutic potential of curcumin in acute and chronic lung injuries. occupational and environmental exposures to mineral dusts, airborne pollutants, cigarette smoke, chemotherapy, and radiotherapy injure the lungs, resulting in acute and chronic inflammatory lung diseases. despite major advances in treating lung diseases, until now disease-modifying efficacy has not been demonstrated for any of the existing drugs. current medi ...	2007	17569221
beneficial role of curcumin in skin diseases.	in recent years, considerable interest has been focused on curcumin a compound, isolated from turmeric. curcumin is used as a coloring, flavoring agent and has been traditionally used in medicine and cuisine in india. the varied biological properties of curcumin and lack of toxicity even when administered at higher doses makes it attractive to explore its use in various disorders like tumors of skin, colon, duodenum, pancreas, breast and other skin diseases. this chapter reviews the data on the ...	2007	17569219
immunomodulation by curcumin.	turmeric, the bright yellow spice extracted from the tuberous rhizome of the plant curcuma longa, has been used in traditional indian and chinese systems of medicine for centuries to treat a variety of ailments, including jaundice and hepatic disorders, rheumatism, anorexia, diabetic wounds, and menstrual difficulties. most of the medicinal effects of turmeric have been attributed to curcumin, the principal curcumanoid found in turmeric. recent evidence that curcumin exhibits strong anti-inflamm ...	2007	17569218
radioprotection and radiosensitization by curcumin.	this chapter gives an overview of the radioprotective and radiosensitizing effect of curcumin. ionizing radiations interact with biological molecules inducing radiolytic products like e(aq), oh, h, -oh, +h, o2, and peroxides. these free radicals damage important biomolecules and subsequently inflict deleterious effects in the organism. whole-body exposure to ionizing radiations results in central nervous system, gastrointestinal tract, and bone marrow syndromes, whereas chronic irradiation cau ...	2007	17569217
regulation of cox and lox by curcumin.	turmeric (curcuma longa) is extensively used as a household remedy for various diseases. for the last few decades, work has been done to establish the biological activities and pharmacological actions of curcumin, the principle constituent of turmeric. curcumin has proven to be beneficial in the prevention and treatment of a number of inflammatory diseases due to its anti-inflammatory activity. arachidonic acid-derived lipid mediators that are intimately involved in inflammation are biosynthesiz ...	2007	17569213
cancer chemopreventive effects of curcumin.	chemoprevention, which is referred to as the use of nontoxic natural or synthetic chemicals to intervene in multistage carcinogenesis, has emerged as a promising and pragmatic medical approach to reduce the risk of cancer. numerous components of edible plants, collectively termed "phytochemicals" have been reported to possess substantial chemopreventive properties. curcumin, a yellow coloring ingredient derived from curcuma longa l. (zingiberaceae), is one of the most extensively investigated an ...	2007	17569209
curcumin in cell death processes: a challenge for cam of age-related pathologies.	curcumin, the yellow pigment from the rhizoma of curcuma longa, is a widely studied phytochemical which has a variety of biological activities: anti-inflammatory and anti-oxidative. in this review we discuss the biological mechanisms and possible clinical effects of curcumin treatment on cancer therapy, and neurodegenerative diseases such as alzheimer's disease, with particular attention to the cell death processes induced by curcumin. since oxidative stress and inflammation are major determinan ...	2007	17549234
new sesquiterpenes and calebin derivatives from curcuma longa.	one novel sesquiterpene with new skeleton, (6s)-2-methyl-6-(4-hydroxyphenyl-3-methyl)-2-hepten-4-one (1), two new bisabolane sesquiterpenes, (6s)-2-methyl-6-(4-hydroxyphenyl)-2-hepten-4-one (2), (6s)-2-methyl-6-(4-formylphenyl)-2-hepten-4-one (3), and two calebin derivatives, 4''-(4'''-hydroxyphenyl-3'''-methoxy)-2''-oxo-3''-butenyl-3-(4'-hydroxyphenyl)-propenoate (4) and 4''-(4'''-hydroxyphenyl)-2''-oxo-3''-butenyl-3-(4'-hydroxyphenyl-3'-methoxy)-propenoate (5) were isolated along with five kno ...	2007	17541200
health risk assessment of villagers who live near a lead mining area: a case study of klity village, kanchanaburi province, thailand.	this was a cross-sectional study aimed at assessing environmental lead exposure and its association with blood lead levels, teeth lead levels and iq of the inhibitants who live near lead mining in kanchanaburi province, thailand. two hundred fifteen villagers from 6 villages participated in this study. exposed and non-exposed villagers were asked to perform iq tests based on raven's standard progressive matrices. environmental, blood and tooth samples were collected and analyzed to determine an ...	2007	17539264
carbohydrate metabolism in dioscorea esculenta (lour.) burk. tubers and curcuma longa l. rhizomes during two phases of dormancy.	we have examined the changes in carbohydrate metabolism in food yam (dioscorea esculenta (lour.) burk.) tubers and in an economically important spice cum medicinal plant turmeric (curcuma longa l.) rhizomes under storage. both specimens showed varied levels of dormancy and sprouting appeared at the end of dormant period. harvested, fully matured tubers of yam and rhizomes of turmeric were stored in wooden boxes under the conditions of 28+/-2 degrees c temperature and 65-75% relative humidity (rh ...	2007	17531451
curcumin, demethoxycurcumin, bisdemethoxycurcumin, tetrahydrocurcumin and turmerones differentially regulate anti-inflammatory and anti-proliferative responses through a ros-independent mechanism.	curcumin, a component of turmeric (curcuma longa), has been shown to exhibit chemopreventive activity. whether analogs of curcumin (cur), such as demethoxycurcumin (dmc), bisdemethoxycurcumin (bdmc), tetrahydrocurcumin (thc) and turmerones, modulate inflammatory signaling and cell proliferation signaling to same extent as curcumin was investigated. the results indicate that the relative potency for suppression of tumor necrosis factor (tnf)-induced nuclear factor-kappab (nf-kappab) activation wa ...	2007	17522064
diabetic retinopathy: an indian perspective.	diabetic retinopathy (dr) can be defined as damage to microvascular system in the retina due to prolonged hyperglycaemia. the prevalence of dr in the chennai urban rural epidemiology (cures) eye study in south india was 17.6 per cent, significantly lower than age-matched western counterparts. however, due to the large number of diabetic subjects, dr is likely to pose a public health burden in india. cures eye study showed that the major systemic risk factors for onset and progression of dr are d ...	2007	17496357
natural products as a gold mine for arthritis treatment.	arthritis, an inflammation of the joints, is usually a chronic disease that results from dysregulation of pro-inflammatory cytokines (e.g. tumour necrosis factor and interleukin-1beta) and pro-inflammatory enzymes that mediate the production of prostaglandins (e.g. cyclooxygenase-2) and leukotrienes (e.g. lipooxygenase), together with the expression of adhesion molecules and matrix metalloproteinases, and hyperproliferation of synovial fibroblasts. all of these factors are regulated by the activ ...	2007	17475558
the safety and efficacy of a dietary herbal supplement and gallic acid for weight loss.	the objective of this study was to test the safety and efficacy of nt, a dietary herbal supplement made from rhubarb, ginger, astragulus, red sage, and turmeric, combined with gallic acid (ga) to reduce food intake and cause weight loss. a total of 105 healthy subjects, 18-60 years old with a body mass index of 25-35 kg/m(2) and on no chronic medication, were randomized to a 300 mg/1.2 g nt-ga combination, a 600 mg/2.4 g nt-ga combination, or placebo in three divided doses daily for 24 weeks. fo ...	2007	17472485
curcuma longa extract as a histological dye for collagen fibres and red blood cells.	crude ethanolic extract and column chromatographic fractions of the allepey cultivar of curcuma longa roxb, commonly called turmeric (tumeric) in commerce, were used as a stain for tissue sections. staining was carried out under basic, acidic and neutral media conditions. inorganic and organic dissolution solvents were used. the stain was used as a counterstain after alum and iron haematoxylins. c. longa stained collagen fibres, cytoplasm, red blood cells and muscle cells yellow. it also stained ...	2007	17451535
in vitro assessment of curcumin against murine neuroblastoma cells.	neuroblastoma (nb) is a well-known malignant disease in infants, which comprises 10% of childhood malignancies. despite recent advances in understanding the neuro-oncology, nb still accounts for more death in childhood than any other cancer. research in childhood tumors should not only be focused on the malignant signatures of cancer cells but also novel drug prototypes using phytochemicals. the present study was aimed to determine the role of curcumin against murine neuroblastoma cell line (n2a ...	2007	17435663
molecular interactions between dimethoxycurcumin and pamam dendrimer carriers.	dimethoxycurcumin, a lipophilic analog of curcumin found as a major pigment in the indian species turmeric (curcuma longa linn.), is known to possess significant activity against various cancer cell lines, but its use as an anticancer drug is hindered by its poor water solubility. the conjugation of dimethoxycurcumin to water-soluble pamam dendrimers (generations 3.5 and 4) is demonstrated. the maximum drug-dendrimer incorporation efficiency is 4.3 and 5.0 molar for g3.5 and g4, respectively. th ...	2007	17428628
kumkum-induced dermatitis: an analysis of 46 cases.	kumkum is a commonly used cosmetic in india, traditionally based on turmeric powder, and its ingredients can cause various types of dermatosis. we undertook a study to characterize kumkum-induced dermatitis clinically and to identify by patch testing the allergens involved. in total, 46 patients with kumkum-induced dermatitis (mean age of these cases 46.5 years; female : male ratio 1.8 : 1) were investigated. the forehead was the most commonly involved site (31/46), followed by the glabellar are ...	2007	17425647
preparation of an enteric-soluble solid-state emulsion using oily drugs.	to improve the patient's compliance and enhance the stability of oily drugs in the gastric fluid, an enteric-soluble solid-state emulsion (ese), was developed. the ese was prepared by spreading liquid o/w-emulsions on a flat glass and drying at the oven maintained at 40 degrees c. aerosil 200 was applied as solid carrier and emulsifier. and eudragit l30d-55 was used as enteric coating material. the influence of various preparation parameters on the residual volatile oil and the release behavior ...	2007	17349753
nmr study of the solution structure of curcumin.	curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione] is derived from the rhizomes of curcuma longa. although early studies concluded that curcumin exists predominantly as a keto-enol tautomer, 1b, in several recent articles the solution structure of curcumin has been represented as a beta-diketone tautomer, 1a. we have investigated the structure of curcumin in solvents ranging in polarity from cdcl3 to mixtures of dmso-d6 in water, and in buffered aqueous dmso-d6 solutions with ...	2007	17315954
characterization and identification of diarylheptanoids in ginger (zingiber officinale rosc.) using high-performance liquid chromatography/electrospray ionization mass spectrometry.	in our continuing investigation of diarylheptanoids in zingiberaceae plants using liquid chromatography/electrospray ionization mass spectrometry (lc/esi-ms/ms), 26 diarylheptanoids were identified from fresh ginger rhizome. of the 26 compounds, 15 diarylheptanoids appear to be new compounds. in addition, the majority of these compounds (18) were acetylated, which is different from our investigation of diarylheptanoids from turmeric, another member of the zingiberaceae, which did not possess any ...	2007	17238228
synthesis of novel curcumin analogues and their evaluation as selective cyclooxygenase-1 (cox-1) inhibitors.	curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. recent studies have indicated that cyclooxygenase-1 (cox-1) plays an important role in inflammation and carcinogenesis. in order to find more selective cox-1 inhibitors a series of novel curcumin derivatives was synthesized and evaluated for their ability to inhibit this enzyme using in vitro inhibition assays for cox-1 and cox-2 by measuring pge(2) productio ...	2007	17202703
curcumin/turmeric solubilized in sodium hydroxide inhibits hne protein modification--an in vitro study.	free radical mediated lipid peroxidation has been implicated in multiple diseases. a major oxidation by-product of this deleterious process is 4-hydroxy-2-nonenal (hne). hne is cytotoxic, mutagenic and genotoxic and is involved in disease pathogenesis. curcumin, a non-steroidal anti-inflammatory agent (occurring as the yellow pigment found in the rhizomes of the perennial herb curcuma longa known as turmeric), has emerged as the newest "nutraceutical" agent that has been shown to be efficacious ...	2007	17116380
curcumin opens cystic fibrosis transmembrane conductance regulator channels by a novel mechanism that requires neither atp binding nor dimerization of the nucleotide-binding domains.	cystic fibrosis transmembrane conductance regulator (cftr) chloride channels are essential mediators of salt transport across epithelia. channel opening normally requires atp binding to both nucleotide-binding domains (nbds), probable dimerization of the two nbds, and phosphorylation of the r domain. how phosphorylation controls channel gating is unknown. loss-of-function mutations in the cftr gene cause cystic fibrosis; thus, there is considerable interest in compounds that improve mutant cftr ...	2007	17178710
curcumin enhances apo2l/trail-induced apoptosis in chemoresistant ovarian cancer cells.	curcumin, the active component of turmeric (curcuma longa), exhibits growth inhibitory activity against prostate, colon, and breast cancer; however, the effect of curcumin on ovarian cancer cells is not known. we hypothesized that curcumin could induce cell death in ovarian cancer cells, and enhance apoptosis induced by tumor necrosis factor-related apoptosis inducing apo2 ligand/trail.	2007	17174384
mitochondrial dysfunction, free radical generation and cellular stress response in neurodegenerative disorders.	protein conformational diseases, such as alzheimer's, parkinson's and huntington's, affect a large portion of aging population. the pathogenic dysfunctional aggregation of proteins in non-native conformations is associated with metabolic derangements and excessive production of reactive oxygen species. reduction of cellular expression and activity of antioxidant proteins result in increased oxidative stress. free-radicals derived from mitochondrial dysfunction and from the cyclooxygenase enzyme ...	2007	17127365
quantitative determination of eight components in rhizome (jianghuang) and tuberous root (yujin) of curcuma longa using pressurized liquid extraction and gas chromatography-mass spectrometry.	curcuma longa (zingiberaceae) is a native plant of southern asia and is cultivated extensively throughout the warmer parts of the world. jianghuang and yujin are rhizome and tuberous root of c. longa, respectively, which were traditionally used as two chinese medicines. in this paper, pressurized liquid extraction (ple) and gas chromatography-mass spectrometry (gc-ms) were developed for quantitative determination/estimation of eight characteristic compounds including beta-caryophyllene, ar-curcu ...	2007	16930909
c-abl kinase regulates curcumin-induced cell death through activation of c-jun n-terminal kinase.	curcumin, a natural phenolic compound found in turmeric (curcuma longa) exhibits anticancer properties, attributed to its antiproliferative and apoptosis-inducing activity. the ubiquitously expressed nonreceptor tyrosine kinase c-abl regulates stress responses induced by oxidative agents such as ionizing radiation and h2o2. in this study, we show that c-abl is an important component of the cell death response activated by curcumin and that abl mediates this response partly through activation of ...	2007	17021249
preclinical assessment of curcumin as a potential therapy for b-cll.	curcumin, the principle component of the spice turmeric, has been used as an anti-inflammatory medication in india and china for centuries. recent studies, predominantly using actively dividing cell lines, have suggested that this compound could be used as a chemopreventative or therapeutic agent for epithelial tumors. as curcumin has been reported to inhibit the nik/ikk complex, an activity that would be expected to induce apoptosis in b cell malignancies, we sought to determine whether curcumi ...	2007	16947318
screening and analysis of bioactive compounds in traditional chinese medicines using cell extract and gas chromatography-mass spectrometry.	as the cost of drug development is always many times more than that of drug discovery, predictive methods aiding in the screening of bioavailable drug candidates are of profound significance. in this paper, a novel method for screening bioactive compounds from traditional chinese medicines (tcms) was developed by using living cell extract and gas chromatography (gc)-mass spectrometer (ms). the method was validated by using elemene emulsion injection (eei), a typical tcm with known active compoun ...	2007	16876368
physico-chemical studies on the evaluation of the antioxidant activity of herbal extracts and active principles of some indian medicinal plants.	understanding of the efficacy and mechanism for the reaction of the biologically important radicals with natural and/or synthetic antioxidants is the first step towards the development of future therapeutic agents. the kinetic parameters e.g., formation and decay rate constants predict the efficacy of an antioxidant and its fate after reaction. these parameters also dictate the ease with which competing reactions would occur in a bio-environment. the spectroscopic parameters provide the clue to ...	2007	18398494
mechanism of the anti-inflammatory effect of curcumin: ppar-gamma activation.	curcumin, the phytochemical component in turmeric, is used as a dietary spice and a topical ointment for the treatment of inflammation in india for centuries. curcumin (diferuloylmethane) is relatively insoluble in water, but dissolves in acetone, dimethylsulphoxide, and ethanol. commercial grade curcumin contains 10-20% curcuminoids, desmethoxycurcumin, and bisdesmethoxycurcumin and they are as effective as pure curcumin. based on a number of clinical studies in carcinogenesis, a daily oral dos ...	2007	18274631
solubility of core materials in aqueous polymeric solution effect on microencapsulation of curcumin.	curcumin, the main active constituent of turmeric herb (curcuma longa l.) have been reported to possess many medicinal values. the application of curcumin in dermatological preparations is limited by their intense yellow color property, which stains the fabric and skin. the objectives of this study were to reduce the color staining effect and enhance the stability of curcumin via microencapsulation using gelatin simple coacervation method. as for curcumin, ethanol and acetone were used as coacer ...	2007	18058323
rapid identification of curcuma longa and c. aromatica by lamp.	we have developed a novel method for the identification of curcuma longa and c. aromatica called "loop-mediated isothermal amplification (lamp)," based on trnk gene sequences. lamp employs four primers that recognize six regions on the target dna. cycling elongation was initiated when the four primers were annealed to the target dna. amplifications were detected by measuring turbidity due to the formation of magnesium pyrophosphate. we designed allele-specific primer sets for c. longa and c. aro ...	2007	17978508
in vitro synthesis of curcuminoids by type iii polyketide synthase from oryza sativa.	curcuminoids, major components of the spice turmeric, are used as a traditional asian medicine and a food additive. curcumin, a representative curcuminoid, has received a great deal of attention because of its anti-inflammatory, anticarcinogenic, and antitumor activities. here we report a novel type iii polyketide synthase named curcuminoid synthase from oryza sativa, which synthesizes bisdemethoxycurcumin via a unique mechanism from two 4-coumaroyl-coas and one malonyl-coa. the reaction begins ...	2007	17932040
curcumin contributes to in vitro removal of non-transferrin bound iron by deferiprone and desferrioxamine in thalassemic plasma.	non-transferrin-bound iron (ntbi) is detectable in plasma of beta-thalassemia patients with transfusional iron overload. this form of iron may cause oxidative tissue damage and increased iron uptake, into several vital organs. removal of ntbi species is incomplete and transient using standard intermittent desferrioxamine (dfo) or deferiprone (dfp) monotherapy. combinations of these or other chelators may improve the protection time from ntbi and increase removal of harmful ntbi species. curcumin ...	2007	17897073
improving the solubility and pharmacological efficacy of curcumin by heat treatment.	lipid peroxidation has been implicated in a variety of diseases. 4-hydroxy-2-nonenal (hne), a major oxidation by-product, is cytotoxic, mutagenic, and genotoxic, being involved in disease pathogenesis. naturally occurring pharmacologically active small molecules are very attractive as natural nonsteroidal anti-inflammatory agents. interest has greatly increased recently in the pharmacotherapeutic potential of curcumin, the yellow pigment found in the rhizomes of the perennial herb curcuma longa ...	2007	17767425
curcumin is a modulator of bilayer material properties.	curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione) is the major bioactive compound in turmeric (curcuma longa) with antioxidant, antiinflammatory, anticarcinogenic, and antimutagenic effects. at low mum concentrations, curcumin modulates many structurally and functionally unrelated proteins, including membrane proteins. because the cell membranes' lipid bilayer serves as a gate-keeper and regulator of many cell functions, we explored whether curcumin modifies general bilayer ...	2007	17705403
the antidepressant effects of curcumin in the forced swimming test involve 5-ht1 and 5-ht2 receptors.	curcuma longa is a main constituent of many traditional chinese medicines, such as xiaoyao-san, used to manage mental disorders effectively. curcumin is a major active component of c. longa and its antidepressant-like effect has been previously demonstrated in the forced swimming test. the purpose of this study was to explore the possible contribution of serotonin (5-ht) receptors in the behavioral effects induced by curcumin in this animal model of depression. 5-ht was depleted by the tryptopha ...	2008	17942093
curcumin down-regulates the multidrug-resistance mdr1b gene by inhibiting the pi3k/akt/nf kappa b pathway.	curcumin, a constituent of turmeric, has anti-inflammatory, anti-carcinogenic, and chemopreventive effects in several animal tumor models. the expression of p-glycoprotein (p-gp), encoded by the mdr gene, is often associated with multidrug resistance (mdr) to unrelated chemotherapeutic drugs in cancer cells. here, we demonstrate that curcumin down-regulates p-gp expression in multidrug-resistant l1210/adr cells. transfection with a series of 5'-deleted constructs of the mdr1b gene promoter indic ...	2008	18006147
cell cycle control as a basis for cancer chemoprevention through dietary agents.	the development of cancer is associated with disorders in the regulation of the cell cycle. the purpose of this review is to briefly summarize the known sequence of events that regulate cell cycle progression with an emphasis on the checkpoints and the mechanisms cell employ to insure dna stability in the face of genotoxic stress. key transitions in the cell cycle are regulated by the activities of various protein kinase complexes composed of cyclin and cyclin-dependent kinases (cdk) molecules. ...	2008	17981702
dietary supplements for osteoarthritis.	a large number of dietary supplements are promoted to patients with osteoarthritis and as many as one third of those patients have used a supplement to treat their condition. glucosamine-containing supplements are among the most commonly used products for osteoarthritis. although the evidence is not entirely consistent, most research suggests that glucosamine sulfate can improve symptoms of pain related to osteoarthritis, as well as slow disease progression in patients with osteoarthritis of the ...	2008	18246887
curcumin inhibits aggregation of alpha-synuclein.	aggregation of amyloid-beta protein (abeta) is a key pathogenic event in alzheimer's disease (ad). curcumin, a constituent of the indian spice turmeric is structurally similar to congo red and has been demonstrated to bind abeta amyloid and prevent further oligomerization of abeta monomers onto growing amyloid beta-sheets. reasoning that oligomerization kinetics and mechanism of amyloid formation are similar in parkinson's disease (pd) and ad, we investigated the effect of curcumin on alpha-synu ...	2008	18189141
quantitative cellular uptake, localization and cytotoxicity of curcumin in normal and tumor cells.	using absorption and fluorescence spectroscopic methods, quantitative cellular uptake of curcumin, an antioxidant and anti-tumor agent from curcuma longa, was calculated in two types of normal cells: spleen lymphocytes, and nih3t3 and two tumor cell lines: el4 and mcf7. both the uptake and fluorescence intensity of curcumin were significantly higher in tumor cells compared to the normal cells. a linear dependency on the uptake was observed with treatment concentration of curcumin. using laser co ...	2008	18178166
new biological activity against phospholipase a2 by turmerin, a protein from curcuma longa l.	turmerin is a protein from turmeric (curcuma longa l.) with a relative molecular mass of 14 kda. the protein inhibits the enzymatic activity and neutralizes the pharmacological properties, such as cytotoxicity, oedema and myotoxicity of multitoxic phospholipase a2 (nv-pla2) of cobra (naja naja) venom at a 1:2.5 molar ratio of nv-pla2:turmerin. a lineweaver-burk plot indicates that turmerin follows a linear mixed type of inhibition.	2008	18177267
effects of turmeric extract on the pharmacokinetics of nifedipine after a single oral administration in healthy volunteers.	the effects of turmeric extracts on the pharmacokinetics of nifedipine were examined in 10 healthy volunteers. an open-label and randomized crossover study was performed at 2-week intervals. in the control experiment, after a 10 h overnight fast, 10 mg of nifedipine (adalat® capsule) was administered orally and blood was collected at 0, 0.5, 1, 2, 3, 4, 5, 6, and 8 h. in the combination experiment, the volunteers were orally administered 10 mg of nifedipine together with six tablets containing c ...	2008	22436099
the effect of curcumin (turmeric) on alzheimer's disease: an overview.	this paper discusses the effects of curcumin on patients with alzheimer's disease (ad). curcumin (turmeric), an ancient indian herb used in curry powder, has been extensively studied in modern medicine and indian systems of medicine for the treatment of various medical conditions, including cystic fibrosis, haemorrhoids, gastric ulcer, colon cancer, breast cancer, atherosclerosis, liver diseases and arthritis. it has been used in various types of treatments for dementia and traumatic brain injur ...	2008	19966973
cytotoxic effects of curcumin on osteosarcoma cell lines.	curcumin (diferuloylmethane), one of the main components of the indian spice turmeric, is known to possess potent anti-inflammatory and anti-oxidant properties. in addition, curcumin has also been shown to have in vitro and in vivo efficacy against a variety of malignancies. in the current study we examined the cytotoxic effect of curcumin on seven osteosarcoma (os) cell lines with varying degrees of in vivo metastatic potential. curcumin inhibited the growth of all os cell lines tested with hal ...	2008	18071634
modulation of steroid activity in chronic inflammation: a novel anti-inflammatory role for curcumin.	the expression of nf-kappab (nf-kappab)-dependent pro-inflammatory genes in response to oxidative stress is regulated by the acetylation-deacetylation status of histones bound to the dna. it has been suggested that in severe asthma and in chronic obstructive pulmonary disease (copd) patients, oxidative stress not only activates the nf-kappab pathway but also alters the histone acetylation and deacetylation balance via post-translational modification of histone deacetylases (hdacs). corticosteroi ...	2008	18327875
direct and indirect antioxidant properties of inducers of cytoprotective proteins.	cellular protection against oxidative and electrophile toxicities is provided by two types of small-molecule antioxidants: (i) direct antioxidants, which are redox active, short-lived, are sacrificed in the process of their antioxidant actions and need to be replenished or regenerated, and may evoke pro-oxidant effects; and (ii) indirect antioxidants, that may or may not be redox active. indirect antioxidants activate the keap1/nrf2/are pathway resulting in transcriptional induction of a battery ...	2008	18327872
microwave assisted extraction of curcumin by sample-solvent dual heating mechanism using taguchi l9 orthogonal design.	the present work reports on a novel extraction method using microwaves based on solvent-sample duo-heating synergism, for the extraction of curcumin from curcuma longa l. the duo-heating mechanism is based on simultaneous heating of sample matrix and extracting solvent under microwave energy. methanol soaked plant material was used as a modifier to bring about selective and effective heating of the sample under microwave. acetone was used as the extracting solvent, which has excellent curcumin s ...	2008	18309573
the potential role of curcumin (diferuloylmethane) in plasma cell dyscrasias/paraproteinemia.	plasma cell dyscrasias, most commonly associated with paraproteinemia, are a diverse group of diseases. monoclonal gammopathy of undefined significance (mgus) can precede multiple myeloma, a progressive neoplastic disease. mgus occurs in association with a variety of other diseases and currently no treatment is recommended but rather "watchful waiting". given that the size of the m-protein is a risk factor for disease progression, early intervention with the aim of reducing the paraprotein load ...	2008	19707439
[curcumin in the treatment of prostatic diseases].	the use of turmeric, derived from the root of the plant curcuma longa, for the treatment of various diseases has been described in ayurveda and in traditional chinese medicine for thousands of years. the active component of turmeric responsible for this activity, curcumin, was identified almost two centuries ago. extensive research over the last decade has indicated that this polyphenol can both prevent and treat prostatic diseases.	2008	18297817
curcumin inhibition of integrin (alpha6beta4)-dependent breast cancer cell motility and invasion.	curcumin, a polyphenol natural product isolated from the rhizome of the plant curcuma longa, has emerged as a promising anticancer therapeutic agent. however, the mechanism by which curcumin inhibits cancer cell functions such as cell growth, survival, and cell motility is largely unknown. we explored whether curcumin affects the function of integrin alpha(6)beta(4), a laminin adhesion receptor with an established role in invasion and migration of cancer cells. here we show that curcumin signifi ...	2008	19138983
curcumin attenuates acrylamide-induced cytotoxicity and genotoxicity in hepg2 cells by ros scavenging.	acrylamide (aa), a proven rodent carcinogen, has recently been discovered in foods heated at high temperatures. this finding raises public health concerns. in our previous study, we found that aa caused dna fragments and increase of reactive oxygen species (ros) formation and induced genotoxicity and weak cytotoxicity in hepg2 cells. presently, curcumin, a natural antioxidant compound present in turmeric was evaluated for its protective effects. the results showed that curcumin at the concentrat ...	2008	19012407
natural derivatives of curcumin attenuate the wnt/beta-catenin pathway through down-regulation of the transcriptional coactivator p300.	curcumin, a component of turmeric (curcuma longa), has been reported to suppress beta-catenin response transcription (crt), which is aberrantly activated in colorectal cancer. however, the effects of its natural analogs (demethoxycurcumin [dmc] and bisdemethoxycurcumin [bdmc]) and metabolite (tetrahydrocurcumin [thc]) on the wnt/beta-catenin pathway have not been investigated. here, we show that dmc and bdmc suppressed crt that was activated by wnt3a conditioned-medium (wnt3a-cm) without alterin ...	2008	19000900
[study on extracting process for tiao zhian mixture].	to study the technology of optimal extraction for tiao zhian mixture.	2008	18661837
synergistic effects of multiple natural products in pancreatic cancer cells.	pancreatic cancer (pc) remains the fourth most common cause of cancer related death in the united states. therefore, novel strategies for the prevention and treatment are urgently needed. numerous dietary and pharmacological agents have been proposed as alternative strategies for the prevention and/or treatment of pc. isoflavone is a prominent flavonoid found in soy products and has been proposed to be responsible for lowering the incidence of pc in asians. similarly, curcumin, an active ingredi ...	2008	18640131
review article: new drug formulations, chemical entities and therapeutic approaches for the management of ulcerative colitis.	treatment options for ulcerative colitis (uc) are expanding with the development of novel drug formulations and dosing regimens and new chemical entities. although the goals of medical therapy for uc remain unchanged, that is to induce and to maintain remission, focus has also centred on improving patient compliance, modifying the natural course of disease and healing the mucosa.	2008	18627362
potential of spice-derived phytochemicals for cancer prevention.	although spices have been used for thousands of years and are known for their flavor, taste and color in the food, they are not usually recognized for their medicinal value. extensive research within the last two decades from our laboratory and others has indicated that there are phytochemicals present in spices that may prevent various chronic illnesses including cancerous, diabetic, cardiovascular, pulmonary, neurological and autoimmune diseases. for instance, the potential of turmeric (curcum ...	2008	18612945
the biosynthetic pathway of curcuminoid in turmeric (curcuma longa) as revealed by 13c-labeled precursors.	in order to investigate the biosynthesis of curcuminoid in rhizomes of turmeric (curcuma longa), we established an in vitro culture system of turmeric plants for feeding (13)c-labeled precursors. analyses of labeled desmethoxycurcumin (dmc), an unsymmetrical curcuminoid, by (13)c-nmr, revealed that one molecule of acetic acid or malonic acid and two molecules of phenylalanine or phenylpropanoids, but not tyrosine, were incorporated into dmc. the incorporation efficiencies of the same precursors ...	2008	18603793
[study on growth and dry substance accumulation of curcuma longa].	to explore the growth characteristics of curcuma longa, and provide basis for standardized cultivation.	2008	18590184
antioxidant and radical scavenging properties of curcumin.	curcumin (diferuoyl methane) is a phenolic compound and a major component of curcuma longa l. in the present paper, we determined the antioxidant activity of curcumin by employing various in vitro antioxidant assays such as 1,1-diphenyl-2-picryl-hydrazyl free radical (dpph*) scavenging, 2,2'-azino-bis(3-ethylbenzthiazoline-6-sulfonic acid) (abts) radical scavenging activity, n,n-dimethyl-p-phenylenediamine dihydrochloride (dmpd) radical scavenging activity, total antioxidant activity determinati ...	2008	18547552
anticancer and carcinogenic properties of curcumin: considerations for its clinical development as a cancer chemopreventive and chemotherapeutic agent.	a growing body of research suggests that curcumin, the major active constituent of the dietary spice turmeric, has potential for the prevention and therapy of cancer. preclinical data have shown that curcumin can both inhibit the formation of tumors in animal models of carcinogenesis and act on a variety of molecular targets involved in cancer development. in vitro studies have demonstrated that curcumin is an efficient inducer of apoptosis and some degree of selectivity for cancer cells has bee ...	2008	18496811
role of curcumin in health and disease.	curcumin (diferuloylmethane) is an orange-yellow component of turmeric (curcuma longa), a spice often found in curry powder. in recent years, considerable interest has been focused on curcumin due to its use to treat a wide variety of disorders without any side effects. it is one of the major curcuminoids of turmeric, which impart its characteristic yellow colour. it was used in ancient times on the indian subcontinent to treat various illnesses such as rheumatism, body ache, skin diseases, inte ...	2008	18484280
curcumin and cancer: an "old-age" disease with an "age-old" solution.	cancer is primarily a disease of old age, and that life style plays a major role in the development of most cancers is now well recognized. while plant-based formulations have been used to treat cancer for centuries, current treatments usually involve poisonous mustard gas, chemotherapy, radiation, and targeted therapies. while traditional plant-derived medicines are safe, what are the active principles in them and how do they mediate their effects against cancer is perhaps best illustrated by c ...	2008	18462866
extraction, processing, and storage effects on curcuminoids and oleoresin yields from curcuma longa l. grown in jamaica.	aromatic diarylheptanoid compounds from curcuma longa linn grown in jamaica were quantified by uv-vis spectrophotometry and high-performance liquid chromatographic (hplc) analyses. the oleoresin yields from ethanolic extracts were quantified and evaluated with regard to the effects of the type of postharvesting process and the type of extraction method conducted on the plant material. fresh samples that were hot solvent extracted provided the highest oleoresin yields of 15.7% +/- 0.4 ( n = 3), a ...	2008	18454547
development of curcuminoids hydrogel patch using chitosan from various sources as controlled-release matrix.	in this study, we developed the hydrogel patch containing curcuminoids for application in cosmetic purpose. the powder of curcuminoids extracted from rhizome of curcuma longa linn. was first formulated into o/w microemulsions before incorporating into the polymer solution. the polymer solutions consisted of chitosan derived from various sources or the blended chitosan starch. we found that chitosan from squid pen gave the patch with highest strength and flexibility. after incorporation of curcum ...	2008	18452437
identification and characterization of a super-stable cu-zn sod from leaves of turmeric (curcuma longa l.).	we report a novel super stable superoxide dismutase (sod) extracted from the leaves of curcuma longa l.-a post-harvest waste. the scavenging activity of this sod remains intact both in crude and purified forms before and after heating at boiling temperatures (80-100 degrees c) up to 20 min, autoclaving (6-20 bars up to 10 min) and microwaving (frequency of 2,450 megahertz (mhz) or million cycles per second for 1-3 min). this sod has significant shelf life at room temperature (25-35 degrees c) an ...	2008	18443818
immunomodulatory effects of curcumin in allergy.	recent years have witnessed a global increase in allergy and asthma, particularly in developed countries. attempts to develop effective control measures for allergy and asthma resulted in the exploration of alternate medicines including herbal remedies traditionally used in old world countries. turmeric is known for its multiple health restoring properties, and has been used in treating several diseases including several respiratory disorders. turmeric is a common spice used in the culinary prep ...	2008	18398870
botanical phenolics and brain health.	the high demand for molecular oxygen, the enrichment of polyunsaturated fatty acids in membrane phospholipids, and the relatively low abundance of antioxidant defense enzymes are factors rendering cells in the central nervous system (cns) particularly vulnerable to oxidative stress. excess production of reactive oxygen species (ros) in the brain has been implicated as a common underlying factor for the etiology of a number of neurodegenerative diseases, including alzheimer's disease (ad), parkin ...	2008	19191039
immune defects in alzheimer's disease: new medications development.	alzheimer's disease (ad) is a neurodegenerative disease characterized by the accumulation of intracellular and extracellular aggregates. according to the amyloid beta (abeta) hypothesis, amyloidosis occurring in the brain is a leading cause of neurodegeneration in ad. defects in the innate immune system may decrease the clearance of abeta in the brain. macrophages of most ad patients do not transport abeta into endosomes and lysosomes, and monocytes from ad patients do not efficiently clear abet ...	2008	19090986
newborn umbilical cord and skin care in sylhet district, bangladesh: implications for the promotion of umbilical cord cleansing with topical chlorhexidine.	newborn cord care practices may directly contribute to infections, which account for a large proportion of the four million annual global neonatal deaths. this formative research study assessed current umbilical and skin care knowledge and practices for neonates in sylhet district, bangladesh, in preparation for a cluster-randomized trial of the impact of topical chlorhexidine cord cleansing on neonatal mortality and omphalitis. unstructured interviews (n=60), structured observations (n=20), rat ...	2008	19057570
curcumin suppresses constitutive activation of nuclear factor-kappa b and requires functional bax to induce apoptosis in burkitt's lymphoma cell lines.	we provide evidence that curcumin, a natural compound isolated from rhizomes of plant curcuma longa, induces apoptosis in several burkitt's lymphoma cell lines expressing bax protein (as283a, kk124, and pa682pb), whereas it has no effects in cell lines with no bax expression (bml895 and ca46). our data show that curcumin treatment results in down-regulation of constitutive activation of nuclear factor-kappab (nf-kappab) via generation of reactive oxygen species where it causes conformational cha ...	2008	18852135
survey of heavy metal pollution in four chinese crude drugs and their cultivated soils.	a two-year survey on the residues of heavy metals in four chinese crude drugs and their cultivated soils was conducted. targeted heavy metals were copper (cu), arsenic (as), lead (pb), nickel (ni), and cadmium (cd). herbs surveyed include white peony root (radix paeoniae alba), turmeric root tuber (radix curcumae), thunberg fritillary bulb (bulbus fritillariae thumbergii), and tuber of dwarf lilyturf (radix ophiopogonis). concentrations of all heavy metals were under the permitted levels except ...	2008	18839045
purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin by high-speed countercurrent chromatography.	curcuminoids are substances of great interest because of their important pharmacological activities, particularly anti-inflammatory, anticarcinogenic, and anti-alzheimer's activities. in this study, we report the first procedure and effect of processing for the high, efficient, and useful purification of curcumin, demethoxycurcumin, and bisdemethoxycurcumin from turmeric powder. purification involves high-speed countercurrent chromatographic (hsccc) separation of these curcuminoids using a simpl ...	2008	18826228
evaluation of the radioprotective effect of turmeric extract and vitamin e in mice exposed to therapeutic dose of radioiodine.	the aim of this study was to evaluate the radioprotective effect of turmeric extract (40 mg/kg body weight) and vitamin e (α- tocopherol acetate, 400 iu/kg body weight) supplementation on lipid peroxidation, reduced glutathione and antioxidant defense enzymes in various organs like liver, kidney and salivary glands at 24 h in adult swiss mice. (131)iodine exposure significantly increased lipid peroxidation in kidney and salivary glands in comparison to control animals. pre supplementation with t ...	2008	23105792
alkaloid and sesquiterpenes from the root tuber of curcuma longa.	one new quinoline alkaloid and seven known bisabolane sesquiterpenes: 2-(2'-methyl-1'-propenyl)-4, 6-dimethyl-7-hydroxyquinoline (1), 2, 5-dihydroxybisabola-3, 10-diene (2), 4, 5-dihydroxybisabola-2,10-diene (3), turmeronol a (4), bisacurone (5), bisacurone a (6), bisacurone b (7) , bisacurone c (8), as well as dehydrozingerone (9) and zingerone (10) were isolated from the root tuber of curcuma longa. their structures were identified by spectral evidence. compound 1 is a new compound, compounds ...	2008	18819476
quantitation of curcuminoids in curcuma rhizome by near-infrared spectroscopic analysis.	this study investigated a nondestructive and rapid quantitation method for the curcuminoids, including curcumin, demethoxycurcumin, and bisdemethoxycurcumin, present in turmeric using near-infrared (nir) spectroscopy and multivariate statistics. in the second derivatives of the nir spectra of turmeric samples, two characteristic absorptions of curcuminoids were detected around 1700 and 2300-2320 nm. partial least-squares regression (pls-r) analysis was applied to the nir spectra obtained from 34 ...	2008	18767866
modulation of anti-apoptotic and survival pathways by curcumin as a strategy to induce apoptosis in cancer cells.	apoptosis is a highly regulated mechanism by which cells undergo cell death in an active way. as one of the most challenging tasks concerning cancer is to induce apoptosis in malignant cells, researchers increasingly focus on natural products to modulate apoptotic signaling pathways. curcumin, a natural compound isolated from the plant curcuma longa, has chemopreventive properties, which are mainly due to its ability to arrest cell cycle and to induce apoptosis. this article reviews the main eff ...	2008	18755156
qualitative and quantitative analysis of four species of curcuma rhizomes using twice development thin layer chromatography.	the rhizomes of curcuma phaeocaulis, curcuma kwangsiensis, curcuma wenyujin and curcuma longa are used as ezhu or jianghuang in traditional chinese medicine for a long time. due to their similar morphological characters, it is difficult to distinguish their origins of raw materials used in clinic. in this study, a simple, rapid and reliable twice development tlc method was developed for qualitative and quantitative analysis of the four species of curcuma rhizomes. the chromatography was performe ...	2008	18722068
prevention of hepatotoxicity due to anti tuberculosis treatment: a novel integrative approach.	to evaluate the ability of curcuma longa (cl) and tinospora cordifolia (tc) formulation to prevent anti-tuberculosis (tb) treatment (att) induced hepatotoxicity.	2008	18720535
androgen responsive and refractory prostate cancer cells exhibit distinct curcumin regulated transcriptome.	curcumin (diferuloylmethane) is the major active component of turmeric and is being actively investigated for its anti-cancer properties. to better understand the biological mechanisms of the chemopreventive potential of curcumin in prostate cancer, we have evaluated curcumin regulated transcriptome in prostate cancer cells. hierarchical clustering methods and functional classification of the curcumin-gene expression response (cu-ger) showed temporal co-regulation of genes involved in oxidative ...	2008	18719366
curcumin inhibits osteoclastogenesis by decreasing receptor activator of nuclear factor-kappab ligand (rankl) in bone marrow stromal cells.	curcumin (diferuloylmethane), a pigment derived from turmeric, has anti-oxidant and anti-inflammatory activities. accumulating evidence points to a biochemical link between increased oxidative stress and reduced bone density. osteoclast formation was evaluated in co-cultures of bone marrow stromal cells (bmsc) and whole bone marrow cells (bmc). expression of receptor activator of nuclear factor-kappab ligand (rankl) was analyzed at the mrna and protein levels. exposure to curcumin led to dose-de ...	2008	18719352
dietary turmeric modulates dmba-induced p21ras, map kinases and ap-1/nf-kappab pathway to alter cellular responses during hamster buccal pouch carcinogenesis.	the chemopreventive efficacy of turmeric has been established in experimental systems. however, its mechanism(s) of action are not fully elucidated in vivo. the present study investigates the mechanism of turmeric-mediated chemoprevention in 7,12-dimethylbenz(a)anthracene (dmba)-induced hamster buccal pouch (hbp) carcinogenesis at 2, 4, 6, 10 and 12 weeks. dietary turmeric (1%) led to decrease in dmba-induced tumor burden and multiplicity, and enhanced the latency period in parallel, to its modu ...	2008	18687351
curcumin as "curecumin": from kitchen to clinic.	although turmeric (curcuma longa; an indian spice) has been described in ayurveda, as a treatment for inflammatory diseases and is referred by different names in different cultures, the active principle called curcumin or diferuloylmethane, a yellow pigment present in turmeric (curry powder) has been shown to exhibit numerous activities. extensive research over the last half century has revealed several important functions of curcumin. it binds to a variety of proteins and inhibits the activity ...	2008	17900536
protective capacities of certain spices against peroxynitrite-mediated biomolecular damage.	peroxynitrite, a potent cytotoxic agent, can damage a variety of biomolecules such as proteins, lipids, and dna, and is considered as one of the major pathological causes of several diseases. therefore, it would appear likely that interception of peroxynitrite by certain dietary compounds may represent one mechanism by which such foods may exert their beneficial action in vivo. a number of researchers have speculated that certain spices, rich in phenolics, may, conceivably, act as potential prot ...	2008	18063286
turmeric-based diet can delay apoptosis without modulating nf-kappab in unilateral ureteral obstruction in rats.	the unilateral ureteral obstruction (uuo) model of renal injury in rat is characterized by nuclear factor kappab (nf-kappab) activation and tumour necrosis factor alpha (tnf-alpha) production, which induces apoptosis via activation of caspase 8 resulting in cell death. curcumin, the major component found in turmeric spice, has been reported to provide protection against fibrosis and apoptosis elicited by uuo. this study examined the effects of a turmeric-based diet (5% w/w) on the apoptotic path ...	2008	18088509
curcumin treatment alleviates the effects of glutathione depletion in vitro and in vivo: therapeutic implications for parkinson's disease explained via in silico studies.	oxidative stress has been implicated in the degeneration of dopaminergic neurons in the substantia nigra (sn) of parkinson's disease (pd) patients. an important biochemical feature of presymptomatic pd is a significant depletion of the thiol antioxidant glutathione (gsh) in these neurons resulting in oxidative stress, mitochondrial dysfunction, and ultimately cell death. we have earlier demonstrated that curcumin, a natural polyphenol obtained from turmeric, protects against peroxynitrite-mediat ...	2008	18166164
curcumin induces apoptosis through an ornithine decarboxylase-dependent pathway in human promyelocytic leukemia hl-60 cells.	curcumin, a well-known dietary pigment derived from the food flavoring turmeric (curcuma longa) exhibits anti-proliferative, anti-inflammatory, and anti-oxidative activities. recently, studies have shown that a chemopreventive effect of curcumin could be due to the hyperproduction of reactive oxygen species (ros) inducing apoptosis in tumor cells. in our previous studies, ornithine decarboxylase (odc) overexpression prevented tumor necrosis factor alpha (tnf-alpha)- and methotrexate-induced apop ...	2008	18187158
curcumin inhibits herpes simplex virus immediate-early gene expression by a mechanism independent of p300/cbp histone acetyltransferase activity.	curcumin, a phenolic compound from the curry spice turmeric, exhibits a wide range of activities in eukaryotic cells, including antiviral effects that are at present incompletely characterized. curcumin is known to inhibit the histone acetyltransferase activity of the transcriptional coactivator proteins p300 and cbp, which are recruited to the immediate early (ie) gene promoters of herpes simplex virus type 1 (hsv-1) by the viral transactivator protein vp16. we tested the hypothesis that curcum ...	2008	18191976
synthesis and exploration of novel curcumin analogues as anti-malarial agents.	curcumin, a major yellow pigment and active component of turmeric, has been shown to possess anti-inflammatory and anti-cancer activities. recent studies have indicated that curcumin inhibits chloroquine-sensitive (cq-s) and chloroquine-resistant (cq-r) plasmodium falciparum growth in culture with an ic(50) of approximately 3.25 microm (mic=13.2 microm) and ic(50) 4.21 microm (mic=14.4 microm), respectively. in order to expand their potential as anti-malarials a series of novel curcumin derivati ...	2008	18194869