Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| neem leaf glycoprotein enhances carcinoembryonic antigen presentation of dendritic cells to t and b cells for induction of anti-tumor immunity by allowing generation of immune effector/memory response. | vaccination with neem leaf glycoprotein matured carcinoembryonic antigen (cea) pulsed dendritic cells (dcs) enhances antigen-specific humoral and cellular immunity against cea and restricts the growth of cea(+) murine tumors. nlgp helps better cea uptake, processing and presentation to t/b cells. this vaccination (dcnlgpcea) elicits mitogen induced and cea specific t cell proliferation, ifn gamma secretion and induces specific cytotoxic reactions to cea(+) colon tumor cells. in addition to t cel ... | 2010 | 20472099 |
| deoxygedunin, a natural product with potent neurotrophic activity in mice. | gedunin, a family of natural products from the indian neem tree, possess a variety of biological activities. here we report the discovery of deoxygedunin, which activates the mouse trkb receptor and its downstream signaling cascades. deoxygedunin is orally available and activates trkb in mouse brain in a bdnf-independent way. strikingly, it prevents the degeneration of vestibular ganglion in bdnf -/- pups. moreover, deoxygedunin robustly protects rat neurons from cell death in a trkb-dependent m ... | 2010 | 20644624 |
| deleterious activity of natural products on postures of spodoptera frugiperda (lepidoptera: noctuidae) and diatraea saccharalis (lepidoptera: pyralidae). | the control of lepidoptera pests should be carried out before hatching of their caterpillars to avoid damage to the crops. the aim of this work was to assess the activity of neem (trade name: natuneem, producer: base fértil, chapadão do sul, brazil) and pyroligneous extracts (trade name: biopirol 7m, producer: biocarbo, itabirito, brazil) at 10 ml/l (1%) and 20 ml/l (2%) contents on egg masses of different ages of spodoptera frugiperda smith (lepidoptera: noctuidae) and of diatraea saccharalis f ... | 2010 | 20653245 |
| in vitro antiviral activity of neem (azardirachta indica l.) bark extract against herpes simplex virus type-1 infection. | herpes simplex virus type 1 (hsv-1) causes significant health problems from periodical skin and corneal lesions to encephalitis. we report here that an aqueous extract preparation from the barks of neem plant azardirachta indica acts as a potent entry inhibitor against hsv-1 infection into natural target cells. the neem bark extract (nbe) significantly blocked hsv-1 entry into cells at concentrations ranging from 50 to 100 microg/ml. the blocking activity of nbe was observed when the extract was ... | 2010 | 20041417 |
| the neem limonoids azadirachtin and nimbolide inhibit cell proliferation and induce apoptosis in an animal model of oral oncogenesis. | limonoids from the neem tree (azadirachta indica) have attracted considerable research attention for their cytotoxicity against human cancer cell lines. however, the antiproliferative and apoptosis inducing effects of neem limonoids have not been tested in animal tumour models. the present study was therefore designed to evaluate the relative chemopreventive potential of the neem limonoids azadirachtin and nimbolide in the hamster buccal pouch (hbp) carcinogenesis model by analyzing the expressi ... | 2010 | 19458912 |
| toxicity and potential anti-trypanosomal activity of ethanolic extract of azadirachta indica (maliacea) stem bark: an in vivo and in vitro approach using trypanosoma brucei. | to determine the toxicity and anti-trypanosomal activity of the ethanolic extract of azadirachta indica (maliacea) stem bark, through in vivo and in vitro approach using trypanosoma brucei brucei. | 2010 | 20079420 |
| toxic effects of neem cake extracts on aedes albopictus (skuse) larvae. | in order to investigate its insecticide potential, the neem cake methanol extract was first analyzed and then separated by different solvents. the high-performance liquid chromatography analysis showed that the neem cake methanol extract still contained relevant quantities of nortriterpenes. fractions of increasing polarity were obtained from the separation process: hexane fraction (hp), etoac fraction (ep), n-buoh fraction (bp), and aqueous fraction (wp). the activity of the fractions on aedes ... | 2010 | 20352448 |
| nematicidal natural products from the aerial parts of buddleja crispa. | studies on the aerial parts of buddleja crispa yielded 13 known compounds, nonyl benzoate, hexyl p-hydroxy-cinnamate, ginipin, gardiol, 1-heptacosanol, steroidal galactoside (22 r)-stigmasta-7,9 (11)-dien-22 beta-ol-3beta-o-beta-d-galactopyranoside, 3-methoxy benzoic acid, beta-sitosterol and ursolic acid. besides this two iridoid galactosides buddlejosides a, buddlejosides b and a benzofuran-type sesquiterpene buddlejone have been isolated from the etoac fraction of b. crispa. together with the ... | 2010 | 20461624 |
| nematicidal natural products from the aerial parts of rubus niveus. | studies on the aerial parts of rubus niveus yielded six known compounds, 3,5-dihydroxy benzoic acid c(7)h(6)o(4), (1), gallic acid c(7)h(6)o(5) (2), ethyl galactoside (3), oleanolic acid (4), beta-sitosterol (5) and 3-o-[beta-d-galactopyranosyl-(12)-d-glucopyranoside (6). besides this, a gallic acid derivative with methyl substitution was synthesised as tetramethyl gallate (3). together with this derivative, compounds 1, 2, the alcohol soluble, chloroform soluble and petroleum ether soluble extr ... | 2010 | 20306362 |
| anti-plasmodial effects of azadirachta indica in experimental cerebral malaria: apoptosis of cerebellar purkinje cells of mice as a marker. | malaria is a major public health problem in the world, but treatment of malaria is becoming more difficult due to increasing drug resistance. therefore, the need for alternative drugs is acute. | 2010 | 22558559 |
| mass attenuation coefficients of x-rays in different medicinal plants. | the mass attenuation coefficients of specific parts of several plants, (fruits, leaves, stem and seeds) often used as medicines in the indian herbal system, have been measured employing nai (ti)) detector. the electronic setup used is a nai (ti) detector, which is coupled to mca for analysis of the spectrum. a source of (241)am is used to get x-rays in the energy range 8-32kev from cu, rb, mo, ag and ba targets. in the present study, the measured mass attenuation coefficient of ocimum sanctum, c ... | 2010 | 19910203 |
| sunlight decreased genotoxicity of azadirachtin on root tip cells of allium cepa and eucrosia bicolor. | utilization of neem plant (azadirachta indica a. juss) extract for pest control in agriculture has raised concerns over contamination by the residues to the environment. such residues, particularly azadirachtin (aza), may cause deleterious effect to non-target organisms. this investigation was conducted to find out if aza could be inactivated through exposures to sunlight. activity of aza was assessed as its ability to cause cytotoxic and genotoxic effects in the forms of nuclei abnormality and ... | 2010 | 20452021 |
| comparison of neem or oregano with thiram on organic matter decomposition of a sand loam soil amended with compost, and on soil biological activity. | oregano essential oil and neem have been reported to be effective against soil-borne pathogens and nematodes. the possibility of having an effect on soil properties was the aim of this investigation. moreover, thiram, a common widely used chemical pesticide, was used for comparison. | 2010 | 20355044 |
| regenerative potential of aqueous extract of neem azadirachta indica on the stomach and ileum following ethanol-induced mucosa lesion in adult wistar rats. | the aim of this study was to examine whether neem azadirachta indica possesses regenerative potential on the stomach and ileum at 500 mg/kg dose given every 12 hours after mucosa lesion was brought by the administration of 1 ml of 50% ethanol for 21 consecutive days in adult wistar rats. | 2010 | 27956991 |
| removal of free fatty acid in azadirachta indica (neem) seed oil using phosphoric acid modified mordenite for biodiesel production. | in this study free fatty acids present in azadirachta indica (neem) oil were esterified with our synthesized phosphoric acid modified catalyst. during the esterification, the acid value was reduced from 24.4 to 1.8 mg koh/g oil. synthesized catalyst was characterized by nh(3) tpd, xrd, sem, ftir and tga analysis. during phosphoric acid modification hydrophobic character and weak acid sites of the mordenite were increased, which lead to better esterification when compared to h-mordenite. a kineti ... | 2010 | 20346652 |
| role of honey (madhu) in the management of wounds (dushta vrana). | application of madhu (honey) is one among the shashthi upakrama (sixty treatment modalities) described by sushruta. clinical observation has shown its effectiveness in treatment of dushta vrana (chronic wounds). we report a case of dushta vrana on the anterior aspect of the right leg that was treated successfully with local application of madhu and neem (azadirachata indica) bark decoction. | 2010 | 21455457 |
| purification of azadirachta indica seed cake and its impact on nutritional and antinutritional factors. | azadirachta indica juss. (family meliaceae) is a vital plant with multiple agricultural and medicinal utilities. the seed cake after oil extraction can be a good source of nutrition in animal feed. the limitation to its use is the presence of azadirachtin, salannin, and other bitter constituents. to make it palatable for use as a source of animal nutrition it was detoxified using 50 and 80% methanol and was analyzed for contents of azadirachtin, salannin, and nutritional contents such as total c ... | 2010 | 20218605 |
| azadirachtin poisoning: a case report. | the use of neem-based products is widespread in the indian subcontinent. neem-based pesticides obtained from neem kernels are considered natural and safe. the toxic effects of ingestion and overdose of this pesticide in adults have not been described in this literature. we report the case of a 35-year-old lady who had consumed azadirachtin in an attempt of deliberate self-harm. the patient had features of neurotoxicity because of azadirachtin requiring intensive medical care with mechanical vent ... | 2010 | 20932102 |
| antiplasmodial triterpenoids from the fruits of neem, azadirachta indica. | eight known and two new triterpenoid derivatives, neemfruitins a (9) and b (10), have been isolated from the fruits of neem, azadirachta indica, a traditional antimalarial plant used by asian and african populations. in vitro antiplasmodial tests evidenced a significant activity of the known gedunin and azadirone and the new neemfruitin a and provided useful information about the structure-antimalarial activity relationships in the limonoid class. | 2010 | 20669933 |
| acute and reproductive effects of align, an insecticide containing azadirachtin, on the grape berry moth, lobesia botrana. | azadirachtin, derived from the neem tree, azadirachta indica a. juss (sapindales: meliaceae), seems promising for use in integrated pest management programs to control a variety of pest species. a commercial formulation of azadirachtin, align, has been evaluated against different developmental stages of the european grape berry moth, lobesia botrana denis and schiffermüller (lepidoptera: tortricidae). when administered orally, align reduced the fecundity and fertility of adults treated with 1, 5 ... | 2010 | 20578954 |
| mr imaging findings of neem oil poisoning. | 2010 | 20448012 | |
| development of controlled release formulations of azadirachtin-a employing poly(ethylene glycol) based amphiphilic copolymers. | controlled release (cr) formulations of azadirachtin-a, a bioactive constituent derived from the seed of azadirachta indica a. juss (meliaceae), have been prepared using commercially available polyvinyl chloride, polyethylene glycol (peg) and laboratory synthesized poly ethylene glycol-based amphiphilic copolymers. copolymers of polyethylene glycol and various dimethyl esters, which self assemble into nano micellar aggregates in aqueous media, have been synthesized. the kinetics of azadirachtin- ... | 2010 | 20401782 |
| effect of pest controlling neem and mata-raton leaf extracts on greenhouse gas emissions from urea-amended soil cultivated with beans: a greenhouse experiment. | in a previous laboratory experiment, extracts of neem (azadirachta indica a. juss.) and gliricidia sepium jacquin, locally known as mata-raton, used to control pests on crops, inhibited emissions of co(2) from a urea-amended soil, but not nitrification and n(2)o emissions. we investigated if these extracts when applied to beans (phaseolus vulgaris l.) affected their development, soil characteristics and emissions of carbon dioxide (co(2)) and nitrous oxide (n(2)o) in a greenhouse environment. un ... | 2010 | 20692019 |
| biological detection and analysis of toxicity of organophosphate- and azadirachtin-based insecticides in lathyrus sativus l. | in this study, attention was paid to investigate the effect of organophosphate insecticides, profenofos 40% ec, methyl parathion (metacid) 50% ec, and neem-based product nimbecidine 0.03% ec (from azadirachta indica) on somatic chromosomal behavior, level of leaf protein, and activity of antioxidant enzymes in lathyrus sativus l., the leguminous herb. the experiments on somatic chromosomes of root tip cells of l. sativus l. revealed that most common type of abnormalities were anaphase bridge, ch ... | 2010 | 19618265 |
| detection of a related difference in efficacy of azadirachtin treatments for the control of whiteflies on gerbera jamesonii by testing for interactions in generalised linear models. | within a project cluster, systemical effects of two neem treatments (neem azal u and neem pellet) on the number of trialeurodes vaporariorum (westw.) in gerbera jamesonii flori line maxi were investigated. in order to minimise adverse ecological effects of a product, a new plant protection product can be declared as superior to a reference if it shows the same or a higher effect at a lower dosage. | 2010 | 19924680 |
| modification of cysteine 179 of ikappabalpha kinase by nimbolide leads to down-regulation of nf-kappab-regulated cell survival and proliferative proteins and sensitization of tumor cells to chemotherapeutic agents. | reverse pharmacology, also called the "bedside to bench" approach, that deals with new uses for a well known molecular entity has been used extensively in cancer drug development to identify novel compounds and delineate their mechanisms of action. here, we show that nimbolide, a triterpenoid isolated from azadirachta indica, enhanced the apoptosis induced by inflammatory cytokines and chemotherapeutic agents in tumor cells. this limonoid abrogated the expression of proteins associated with cell ... | 2010 | 20829362 |
| development of a new controlled pesticide delivery system based on neem leaf powder. | in order to minimize the agro-environmental pollution and health hazards caused by pesticides, in the present study, the neem leaf powder "(nlp)", a bio-pesticide, has been exploited to develop the pesticide delivery devices. the presence of neem in the formulations along with the pesticide may enhance the potential of these systems due to its inherent pesticidal activity. we have prepared the nlp and alginate based beads by using cacl(2) as crosslinker. to study the effect of composition of the ... | 2010 | 20042287 |
| efficacy of some oils and chemical compounds on insignorthezia insignis (browne) (hemiptera: ortheziidae) infesting lantana camara in alexandria, egypt. | field and laboratory experiments were conducted in march, 2008 in el-nouzha garden, alexandria governorate. pre-and post treatment inspections of the insects were examined and recorded before and after (2,4,8, and 12 weeks). spraying was applied to evaluate the efficiency of the tested compounds, [mineral oils (kz oil and star oil); igrs (chlorfluazuron, lufenuron and pyriproxyfen); neem oil; emamectin benzoate and thiamethoxam]. percentages of reduction were calculated. the ensign scale insects ... | 2010 | 21539253 |
| air pollution tolerance index (apti) of some tree species growing near rail roads of madurai, tamil nadu (india). | biological monitoring and assessment studies due to urban--rail road pollutants were carried out using air pollution tolerance index (apti) of plants. four plant (leaf) parameters--namely ascorbic acid, total chlorophyll, relative water content and leaf extract ph were combined together in a formulation signifying the apti of plants. apti was calculated for five different species such as azadirachta indica, delonix regia, ficus religiosa, pongamia pinnata and polyalthia longifolia growing in two ... | 2010 | 22312796 |
| toothbrush contamination by candida spp. and efficacy of mouthrinse spray for their disinfection. | the aim of the study was to evaluate toothbrush contamination in vivo by candida spp. and the efficacy of periogard and neem sattiva, in spray, in the disinfection of these toothbrushes. this study was performed in three phases in which mouthrinses and sterile distilled water (control group) were sprayed six times on toothbrush bristles used by 61 university students. toothbrushes were then submitted to microbiological processing for the isolation and identification of candida species. fifty-nin ... | 2010 | 19774487 |
| the blue neck syndrome : nematode larvae in skin scrapings. | a novel non-inflammatory type of pigmentation of the neck associated with nematode larvae on affected skin is described. the name 'blue neck syndrome' is suggested for this condition because of the characteristic clinical appearance. antinematode agents such as albendazole and neem oil have been found to be effective in the treatment. | 2010 | 20877070 |
| antidiabetic properties of azardiracta indica and bougainvillea spectabilis: in vivo studies in murine diabetes model. | diabetes mellitus is a metabolic syndrome characterized by an increase in the blood glucose level. treatment of diabetes is complicated due to multifactorial nature of the disease. azadirachta indica adr. juss and bougainvillea spectabilis are reported to have medicinal values including antidiabetic properties. in the present study using invivo diabetic murine model, a. indica and b. spectabilis chloroform, methanolic and aqueous extracts were investigated for the biochemical parameters importan ... | 2011 | 19389871 |
| antidiabetic indian plants: a good source of potent amylase inhibitors. | diabetes is known as a multifactorial disease. the treatment of diabetes (type ii) is complicated due to the inherent patho-physiological factors related to this disease. one of the complications of diabetes is post-prandial hyperglycemia (pphg). glucosidase inhibitors, particularly α-amylase inhibitors are a class of compounds that helps in managing pphg. six ethno-botanically known plants having antidiabetic property namely, azadirachta indica adr. juss.; murraya koenigii (l.) sprengel; ocimum ... | 2011 | 18955350 |
| an acidic phospholipase a(2) (rvva-pla(2)-i) purified from daboia russelli venom exerts its anticoagulant activity by enzymatic hydrolysis of plasma phospholipids and by non-enzymatic inhibition of factor xa in a phospholipids/ca(2+) independent manner. | a homodimeric acidic pla(2) (rvva-pla(2)-i) of 58.0 kda molecular weight purified from russell's viper (daboia russelli) venom demonstrated dose-dependent catalytic, strong anticoagulant and indirect hemolytic activities and inhibited blood coagulation cascade in both enzymatic and non-enzymatic mechanisms. in in vitro condition, rvva-pla(2)-i showed preferential hydrolysis of phosphatidylcholine with a k(m) and v(max) values of 0.65 mm and 28.9 μmol min(-1), respectively. biochemical study and ... | 2011 | 21356226 |
| efficacy of selected pesticides against synanthropic mites under laboratory assay. | the efficacies of organophosphate pesticides, single-compound versus multicompound pyrethroid formulations and relatively novel unclassified insecticides/acaricides were compared to find the lowest dosage and highest efficacy for the control of dermatophagoides farina (hughes), d. pteronyssinus (trouessart) and tyrophagus putrescentiae (schrank). formulated active ingredients (ais) were diluted in water and applied onto filter paper in experimental chambers with ten unsexed adult mites in six re ... | 2011 | 21264998 |
| effect of azadirachta indica (neem), sodium thiosulphate and calcium chloride on changes in nitrogen transformations and inhibition of nitrification in soil incubated under laboratory conditions. | a laboratory experiment was conducted to examine the effects of nitrification inhibitors (nis) neem seed-cake (azadirachta indica) (nsc), sodium thiosulphate (na₂s₂o₃) and calcium chloride (cacl₂) on changes in nh₄(+)⁻n, inhibition of nitrification and recovery of applied nitrogen (n) in soil. surface soil samples of 0-15 cm were collected from an arable field, amended with urea n (un) at the rate 200 mg n kg⁻¹, un+nsc, un+na₂s₂o₃ and un+cacl₂ and incubated at 22°c periodically over 50 d. soil w ... | 2011 | 21146192 |
| to evaluate the antigingivitis and antipalque effect of an azadirachta indica (neem) mouthrinse on plaque induced gingivitis: a double-blind, randomized, controlled trial. | azadirachta indica (neem), a meliaceae family tree, has been used in india for several decades for the treatment of several diseases in medicine and dentistry. neem has been considered to have antiseptic activity, but still its use for the treatment of gingivitis and periodontitis is not very clear. hence, the purpose of the present study was to assess the efficacy of neem based mouth rinse regarding its antigingivitis effect. | 2011 | 22368367 |
| indian culinary plants enhance glucose-induced insulin secretion and glucose consumption in ins-1 β-cells and 3t3-l1 adipocytes. | six indian plants, commonly used as culinary plants, herbs or spices (kikar; jamun; neem; harad; fenugreek; bitter gourd), were screened and compared for their antidiabetic potential in vitro. aqueous plant extracts were prepared and assessed for their effect on the insulin secretion activity of rat pancreatic ins-1 β-cells and glucose consumption in mouse 3t3-l1 adipocytes in order to study their specific mechanisms of action. the effect of the plant extract concentration (25-1000μg/ml) on insu ... | 2011 | 25212346 |
| increasing the prosthodontic awareness of an aging indian rural population. | the aged are prone to biological, social, and psychological problems, especially those residing in the rural areas. the rural aging population in contrast to their urban counterparts is illiterate, poor, and ignorant; cumulative is the fact that the youth are leaving rural areas for money and better opportunity to urban areas. an educational and motivational program to increase prosthodontic awareness was therefore undertaken and it was studied whether this translated into an increased demand fo ... | 2011 | 22048572 |
| role of chloroplastidial proteases in leaf senescence. | in this report the effect of hydrogen peroxide (h2o2) on peroxidase (pod) activity during leaf senescence was studied with and without phenylmethylsulfonyl fluoride (pmsf) pre-treatment in detached neem (azadirachta indica a. juss) leaf chloroplasts. increased pod activity was detected in natural and h2o2-promoted senescent leaf chloroplasts compared to untreated control mature green leaf chloroplasts. however, under h2o2 pod activity markedly increased at 1 day, and then significantly decreased ... | 2011 | 22024830 |
| assessment of genetic diversity of 12 populations of azadirachta indica a. juss from three different locations in lagos state, nigeria using rapd markers. | the beneficial effects of plant materials typically result from the combination of secondary products present in the plant. neem tree is a common source of natural products for development of medicines against various diseases. | 2011 | 21913540 |
| scalable synthesis of aligned carbon nanotubes bundles using green natural precursor: neem oil. | practical application of aligned carbon nanotubes (acnts) would have to be determined by a matter of its economical and large-scale preparation. in this study, neem oil (also named margoaa oil, extracted from the seeds of the neem--azadirachta indica) was used as carbon source to fabricate the bundles of acnts. acnts have been synthesized by spray pyrolysis of neem oil and ferrocene mixture at 825°c. the major components of neem oil are hydrocarbon with less amount of oxygen, which provided the ... | 2011 | 21711585 |
| increased production of azadirachtin from an improved method of androgenic cultures of a medicinal tree azadirachta indica a. juss. | present report is the first direct evidence of azadirachtin production in androgenic haploid cultures of azadirachta indica, a woody medicinal tree. anther cultures at early-late-uninucleate stage of microspores were established on ms medium with bap (5 μm), 2,4-d (1 μm) and naa (1 μm) containing 12% sucrose. the calli, induced, were further multiplied on 2,4-d and kinetin media. shoots, differentiated on bap (2.2 μm) + naa (0.05 μm) medium, were elongated on ms + bap (0.5 μm) and multiplied on ... | 2011 | 21701249 |
| is a combine therapy of aqueous extract of azadirachta indica leaf (neem leaf) and chloroquine sulphate toxic to the histology of the rabbit cerebellum? | herbal medication is commonly employed in treatment of diseases. aqueous extract of azadirachta indica leaf (a. indica) is commonly used in treatment of malaria by nigerians. most often, aqueous extract of a. indica leaf is taken in combination with chloroquine in order to cure malaria infection without knowledge of the side effect especially by the rural dwellers in nigeria. | 2011 | 23209976 |
| artificial neural network and multiple regression model for nickel(ii) adsorption on powdered activated carbons. | nickel removal efficiency of powered activated carbons of coconut oilcake, neem oilcake and commercial carbon was investigated by using artificial neural network. the effective parameters for the removal of nickel (%r) by adsorption process, which included the ph, contact time (t), distinctiveness of activated carbon (cn), amount of activated carbon (cw) and initial concentration of nickel (co) were investigated. levenberg-marquardt (lm) back-propagation algorithm is used to train the network. t ... | 2011 | 23029923 |
| a comprehensive study on characterization of elite neem chemotypes through mycofloral, tissue-cultural, ecomorphological and molecular analyses using azadirachtin-a as a biomarker. | azadirachtin-a (aza-a), a tetranortriterpenoid, found in minuscule amounts in the neem seed-kernels, has proved to be a potent biopesticide. given the vast biodiversity of azadirachta indica (neem) in india, this study is an overview of four main aspects that corroborate with each other in identifying elite neem chemotypes based on their aza-a content. these biomarkers included mycofloral, tissue-cultural, ecomorphometrical and molecular analyses on accessions from five ecogeographically differe ... | 2011 | 23572995 |
| effect of marble dust on plants around vishwakarma industrial area (vkia) in jaipur, india. | the paper describes the effect of marble dust on plants in and around vishwakarma industrial area (vkia) jaipur, rajasthan (india). trees species growing in and around vkia area were selected and various morphological characteristics were studied such as leaf area dry weight ratio (ladwr), dust retaining capacity (drc) and chlorophyll content. in the study the effects of marble dust on selected tree species was observed. ladwr was recorded maximunm 217.90 cm2 g(-1) dry wt. in polyalthia longifol ... | 2011 | 21882657 |
| neem leaf glycoprotein partially rectifies suppressed dendritic cell functions and associated t cell efficacy in patients with stage iiib cervical cancer. | myeloid-derived dendritic cells (dcs) generated from monocytes obtained from stage iiib cervical cancer (cacx iiib) patients show dysfunctional maturation; thus, antitumor t cell functions are dysregulated. in an objective to optimize these dysregulated immune functions, the present study is focused on the ability of neem leaf glycoprotein (nlgp), a nontoxic preparation of the neem leaf, to induce optimum maturation of dendritic cells from cacx iiib patients. in vitro nlgp treatment of immature ... | 2011 | 21307275 |
| induction of apoptosis and inhibition of pi3k/akt pathway in pc-3 and lncap prostate cancer cells by ethanolic neem leaf extract. | the present study is aimed to delineate the effect of ethanolic neem leaf extract on pi3k/akt and apoptotic pathway in prostate cancer cell lines (pc-3 and lncap). | 2011 | 21277364 |
| standardization of some herbal antidiabetic drugs in polyherbal formulation. | ayurvedic formulations are used to treat a wide variety of diseases including diabetes mellitus standardization of herbal formulation is essential in order to assess the quality of drugs. the present paper reports standardization of eight herbal anti-diabetic drugs-momordica charantia (seeds), syzigium cumini (seeds), trigonella foenum (seeds), azadirachta indica (leaves), emblica offi cinalis (fruits), curcuma longa (rhizomes), gymnema sylvestre (leaves), pterocarpus marsupium (heart-wood) indi ... | 2011 | 21731396 |
| cytotoxic triterpenoids from azadirachta indica. | two new tirucallane triterpenoids, 24,25-epoxy-3 β-hydroxy-20-oxo-7-tirucallene (1) and 22,23;24,25-diepoxy-3 β-hydroxy-7-tirucallene (2), and a new tetranortriterpenoid, 4 α-hydroperoxy-6- o-acetylnimbandiol (3), along with eight known compounds, were isolated from the branches and leaves of azadirachta indica. their structures were elucidated through spectroscopic and chemical methods. the cytotoxic assay showed that the abundant constituent nimbolide (8) had obvious cytotoxic activities again ... | 2011 | 21674442 |
| comparison of the effectiveness of a commercially available herbal mouthrinse with chlorhexidine gluconate at the clinical and patient level. | the key to good oral health is hidden in nature. natural herbs like neem, tulsi, pudina, clove oil, ajwain, triphala and many more has been used since ages either as a whole single herb or as a combination against various oral health problems like bleeding gums, halitosis, mouth ulcers and preventing tooth decay. the aim of the study was to compare the efficacy of a commercially available herbal mouthrinse (herboral) with that of chlorhexidine gluconate which is considered to be a gold standard ... | 2011 | 22368358 |
| prevalence and pattern of use of indigenous medicines in diabetic patients attending a tertiary care centre. | the aim of the study was to see the pattern of use of indigenous medicines in diabetic patients and to find out its correlation with various demographic variables in patients of type 2 diabetes. a sample of 113 patients with diabetes (type 1 and type 2) was interviewed using a structured questionnaire by trained medical personnel about the intake of indigenous medicines. correlation of intake of indigenous medicines with various demographic variables was assessed using appropriate statistical te ... | 2011 | 22315837 |
| organic matrix based slow release fertilizer enhances plant growth, nitrate assimilation and seed yield of indian mustard (brassica juncea l.). | field experiments were conducted to study the effect of organic matrix based slow release fertilizers (srfs) on plant growth, nitrate assimilation and seed yield of brassica juncea l. cv, pusa bold. the agro-waste materials like cow dung, clay soil, neem leaves and rice bran were mixed together in 2:2:1:1 ratio and used as organic matrix for the immobilization of chemical fertilizer nutrients with commercial grade saresh (acacia gum, 15% solution) as binder. different fertilizer treatments were ... | 2011 | 22319878 |
| foliar residue dynamics of azadirachtins following direct stem injection into white and green ash trees for control of emerald ash borer. | azadirachtins are natural insecticides derived from the neem tree. the emerald ash borer (eab) is an exotic invasive insect pest that infests various ash tree species and has the potential for significant economic, aesthetic and ecological impacts throughout north america. the initial translocation and foliar residue dynamics of azadirachtins were examined following direct injection into white and green ash trees growing in urban scenarios as a potential control for eab. | 2011 | 21567888 |
| environmental safety to decomposer invertebrates of azadirachtin (neem) as a systemic insecticide in trees to control emerald ash borer. | the non-target effects of an azadirachtin-based systemic insecticide used for control of wood-boring insect pests in trees were assessed on litter-dwelling earthworms, leaf-shredding aquatic insects, and microbial communities in terrestrial and aquatic microcosms. the insecticide was injected into the trunks of ash trees at a rate of 0.2 gazadirachtin cm(-1) tree diameter in early summer. at the time of senescence, foliar concentrations in most (65%) leaves where at or below detection (<0.01 mg ... | 2011 | 21531021 |
| thrombolytic potential of ocimum sanctum l., curcuma longa l., azadirachta indica l. and anacardium occidentale l. | atherothrombotic diseases such as myocardial or cerebral infarction are serious consequences of the thrombus formed xin blood vessels. thrombolytic agents are used to dissolve the already formed clots in the blood vessels; however, these drugs have certain limitations which cause serious and sometimes fatal consequences. herbal preparations have been used since ancient times for the treatment of several diseases. the aim of this study was to investigate whether herbal preparations possess thromb ... | 2011 | 24826011 |
| status of carbohydrate, protein and lipid profile in the mosquito larvae treated with certain phytoextracts. | to investigate the impact of the most potent petroleum ether extract of artemisia annua (a. annua) and azadirachta indica (az. indica) on total carbohydrate, lipid and protein level of anopheles stephensi and culex quinquefasciatus larvae. | 2011 | 21771474 |
| a comparative study of vamana and virechana karma in the management of sthula pramehi w.s.r. to type-2 diabetes. | in the present study, vamana and virechana along with palliative treatment was given to patients of sthula prameha (diabetes mellitus or dm). an attempt was made to compare and evaluate the role of shodhana therapy (vamana and virechana). total 47 patients of sthula pramehi were registered in this study, out of which 38 completed the treatment. the patients were divided into two groups, viz. vamana with shamana (group a) and virechana with shamana (group b). eighteen patients completed the treat ... | 2011 | 22661850 |
| antifungal activity of different neem leaf extracts and the nimonol against some important human pathogens. | this study was conducted to evaluate the effect of aqueous, ethanolic and ethyl acetate extracts from neem leaves on growth of some human pathogens (aspergillus flavus, aspergillus fumigatus, aspergillus niger, aspergillus terreus, candida albicans and microsporum gypseum) in vitro. different concentrations (5, 10, 15 and 20%) prepared from these extracts inhibited the growth of the test pathogens and the effect gradually increased with concentration. the 20% ethyl acetate extract gave the stron ... | 2011 | 24031718 |
| control of root-knot nematodes on tomato in stone wool substrate with biological nematicides. | the efficacy of four biological nematicides on root-galling, root-knot nematode (meloidogyne incognita) reproduction, and shoot weight of tomato (solanum lycopersicum) grown in stone wool substrate or in pots with sandy soil was compared to an oxamyl treatment and a non-treated control. in stone wool grown tomato, avid® (a.i. abamectin) was highly effective when applied as a drench at time of nematode inoculation. it strongly reduced root-galling and nematode reproduction, and prevented a reduct ... | 2011 | 22791920 |
| the neem [azadirachta indica a. juss (meliaceae)] oil reduction in the in vitro production of zearalenone by fusarium graminearum. | zearalenone, a mycotoxin produced by fungi of the genus fusarium, including f. graminearum, triggers reproduction disorders in certain animals and hyperestrogen syndromes in humans. current research investigates three concentrations of neem oil extract (0.1, 0.25 and 0.5%) in reducing the production of zearalenone. neem oil extract decreased zearalenone amount in the three concentrations but highest inhibition (59.05%) occurred at 0.1%. | 2011 | 24031683 |
| biochemical changes in plant leaves as a biomarker of pollution due to anthropogenic activity. | the air pollution due to anthropogenic activities seriously affected human life, vegetation, and heritage as well. the vegetation cover in and around the city mitigates the air pollution by acting as a sink for pollution. an attempt was made to evaluate biochemical changes occurred in four selected plant species, namely azadirachta indica, mangifera indica, delonix regia, and cassia fistula of residential, commercial, and industrial areas of nagpur city in india. it was observed that the correla ... | 2011 | 20721619 |
| chemopreventive activity of azadirachta indica on two-stage skin carcinogenesis in murine model. | the present study reports the chemopreventive activity of aqueous azadirachta indica leaf extract (aaile) in a murine two-stage skin carcinogenesis model. skin tumors were induced by topical application of 7,12-dimethylbenz(a)anthracene (dmba) (500 nmol/100 µl for 2 weeks) followed by 12-o-tetradecanoylphorbol-13-acetate (tpa) (1.7 nmol/100 µl of acetone, twice weekly) as a promoter. male laca mice were divided into four groups: control, dmba/tpa, aaile and aaile + dmba/tpa. aaile was administer ... | 2011 | 20734334 |
| ethno-veterinary uses and informants consensus factor of medicinal plants of sariska region, rajasthan, india. | the study was conducted in sariska region of rajasthan, india to identify the important species used for ethno-veterinary medicine; finding out methods for various ethno-veterinary medicine preparations, and calculate the informant consensus factor (icf) in relation to medicinal plant use. | 2011 | 20817085 |
| inhibition of virulence potential of vibrio cholerae by natural compounds. | the rise in multi-drug resistant vibrio cholerae strains is a big problem in treatment of patients suffering from severe cholera. only a few studies have evaluated the potential of natural compounds against v. cholerae. extracts from plants like 'neem', 'guazuma', 'daio', apple, hop, green tea and elephant garlic have been shown to inhibit bacterial growth or the secreted cholera toxin (ct). however, inhibiting bacterial growth like common antimicrobial agents may also impose selective pressure ... | 2011 | 21415500 |
| cytotoxic and apoptosis-inducing activities of limonoids from the seeds of azadirachta indica (neem). | thirty-five limonoids, including 15 of the azadiradione type (1-15), five of the gedunin type (16-20), four of the azadirachtin type (21-24), nine of the nimbin type (25-33), and two degraded limonoids (34, 35), isolated from azadirachta indica seed extracts, were evaluated for their cytotoxic activities against five human cancer cell lines. seven compounds (3, 6, 7, 16, 18, 28, and 29) exhibited cytotoxic activity against one or more cell lines. among these compounds, 7-deacetyl-7-benzoylepoxya ... | 2011 | 21381696 |
| comparative effect of integrated pest management and farmers' standard pest control practice for managing insect pests on cabbage (brassica spp.). | studies were conducted on experimental cabbage plantings in 2009 and on experimental and commercial plantings in 2010, comparing farmers' current chemical standard pesticide practices with an integrated pest management (ipm) program based on the use of neem (aza-direct) and dipel (bacillus thuringiensis). in experimental plantings, the ipm program used six or eight applications of neem and dipel on a rotational basis. the standard-practice treatments consisted of six or eight applications of car ... | 2011 | 21413143 |
| Spinosad and neem seed kernel extract as bio-controlling agents for malarial vector, Anopheles stephensi and non-biting midge, Chironomus circumdatus. | Midge egg masses are reported to support non-pathogenic strains of the cholera pathogen, Vibrio cholera (V. cholera). Mosquito born diseases have been reported to cause millions of death worldwide. The present research reveals the toxicity effect of spinosad and neem seed kernel extract (NSKE) against different larval stages of Anopheles stephensi (An. stephensi) and Chironomus circumdatus (Ch. circumdatus). | 2011 | 21914538 |
| medical pluralism on mfangano island: use of medicinal plants among persons living with hiv/aids in suba district, kenya. | given the increasing coverage of antiretroviral therapy (art) for hiv/aids treatment as well as the high utilization of herbal medicine, many persons living with hiv/aids in sub-saharan africa are thought to practice medical pluralism, or the adoption of more than one medical system for their care and treatment. using a cross-sectional study we sought to document and identify the herbal medicines used by persons living with hiv/aids on mfangano island, suba district, nyanza province, kenya. | 2011 | 21458556 |
| neem leaf extract induces radiosensitization in human neuroblastoma xenograft through modulation of apoptotic pathway. | induction of apoptosis is directly correlated with the biological effectiveness of ionizing radiation (ir). accordingly, we investigated the efficacy of neem leaf extract (nle) on ir-associated apoptotic transcriptional modulation and cell death in neuroblastoma (nb). | 2011 | 21273594 |
| ethnobotanical survey of medicinal plants commonly used by kani tribals in tirunelveli hills of western ghats, india. | for thousands of years, medicinal plants have played an important role throughout the world in treating and preventing a variety of diseases. kani tribal people in tirunelveli hills still depend on medicinal plants and most of them have a general knowledge of medicinal plants which are used for first aid remedies, to treat cough, cold, fever, headache, poisonous bites and some simple ailments. | 2011 | 21291981 |
| evaluation of mutagenic and antimutagenic activities of neem (azadirachta indica) seed oil in the in vitro ames salmonella/microsome assay and in vivo mouse bone marrow micronucleus test. | the possible mutagenic and antimutagenic activity of neem oil (no) and its dmso extract (nde) were, examined in the ames salmonella/microsome mutagenicity test and the mouse bone marrow micronucleus assay. | 2011 | 21315815 |
| novel molecular targets of azadirachta indica associated with inhibition of tumor growth in prostate cancer. | advanced prostate cancer has significant long-term morbidity, and there is a growing interest in alternative and complimentary forms of therapy that will improve the outcomes of patients. azadirachta indica (common name: neem) contains multiple active compounds that have potent anti-inflammatory and anticancer properties. the present study investigates the novel targets of the anticancer activity of ethanol extract of neem leaves (eenl) in vitro and evaluates the in vivo efficacy in the prostate ... | 2011 | 21560017 |
| formulation and comparative evaluation of poly herbal anti-acne face wash gels. | context: rauvolfia serpentina (l). benth. ex kurz. (apocynaceae) possessing antibacterial properties are widely used in modern herbal medicines. curcuma longa l. (zingiberaceae), a readily available antiseptic, possess antioxidant, antibacterial, blood purifying and antiinflammatory properties and used in various skin creams. azadirachta indica a. juss. (meliaceae) possess astringent, antiviral, discutient, stimulant and antibacterial properties and works excellently well against acne and keeps ... | 2011 | 21609304 |
| bio-control and plant growth promotion potential of siderophore producing endophytic streptomyces from azadirachta indica a. juss. | three endophytic actinomycetes strains recovered from surface sterilized root tissues of azadirachta indica a. juss. (meliaceae), plants were selected through tests for their potential as bio-control and plant growth promoting agents. it was also observed that the seed treated with the spore suspension of three selected strains of streptomyces, significantly promoted plant growth and antagonized the growth of alternaria alternata, causal agent of early blight disease in tomato plant. it was obse ... | 2011 | 21656792 |
| efficacy of a single treatment of head lice with a neem seed extract: an in vivo and in vitro study on nits and motile stages. | an anti-louse shampoo (licener-«) based on a neem seed extract was tested in vivo and in vitro on its efficacy to eliminate head louse infestation by a single treatment. the hair of 12 children being selected from a larger group due to their intense infestation with head lice were incubated for 10-ámin with the neem seed extract-containing shampoo. it was found that after this short exposition period, none of the lice had survived, when being observed for 22-áh. in all cases, more than 50-70 dea ... | 2011 | 21667206 |
| bioconversion of agricultural waste to ethanol by ssf using recombinant cellulase from clostridium thermocellum. | the effect of different pretreatment methods, temperature, and enzyme concentration on ethanol production from 8 lignocellulosic agrowaste by simultaneous saccharification and fermentation (ssf) using recombinant cellulase and saccharomyces cerevisiae were studied. recombinant cellulase was isolated from e. coli bl21 cells transformed with ctlic26a-cel5-cbm11 full-length gene from clostridium thermocellum and produced in both batch and fed-batch processes. the maximum cell od and specific activi ... | 2011 | 21811671 |
| the effects of combination of methanolic leaf extract of azadirachta indica and diminazene diaceturate in the treatment of experimental trypanosoma brucei brucei infection in rats. | to investigate the effects of combination therapy of methanolic leaf extract of azadirachta indica (a. indica) and diminazene diaceturate (dda) in the treatment of experimental trypanosoma brucei brucei (t. brucei brucei) infection in rats. | 2011 | 21771672 |
| Screening of allelopathic trees for their antifungal potential against Alternaria alternata strains isolated from dying-back Eucalyptus spp. | Antifungal activity of methanolic extracts of leaves of three tree species, namely Azadirachta indica L., Syzygium cumini (L.) Skeels. and Melia azedarach L. was evaluated against two strains of Alternaria alternata, isolated from dying-back trees of two Eucalyptus spp., namely Eucalyptus citriodora and Eucalyptus globulus. All the concentrations (1,?2,?…?,?5% w/v) of the methanolic extracts of the three tree species significantly reduced the fungal biomass. There were reductions in the ranges 8 ... | 2011 | 22007991 |
| effects of a neem seed extract (mitestop®) on mallophages (featherlings) of chicken: in vivo and in vitro studies. | mallophages of birds (featherlings) are mostly very tiny and can even as adults better be recognized by their movements than by their elongate body shape when using just the naked eye. since some species (e.g., the "shaft louse" menopon gallinae, the elongate feather louse lipeurus caponis, or columbicola sp.) may pierce the pulp of feathers or the skin by their biting or scratching mandibles and thus lick the excreted blood, they may be extremely dangerous especially to young birds, even if the ... | 2011 | 21744016 |
| anticancer biology of azadirachta indica l (neem): a mini review. | neem (azadirachta indica), a member of the meliaceae family, is a fast growing tropical evergreen tree with highly branched and stout solid stem. because of its tremendous therapeutic, domestic, agricultural and ethnomedicinal significance, and proximity with human culture and civilization neem has been called as "the wonder tree" and "nature's drug store". all parts of this tree, particularly leaves, bark, seed-oil and their purified products are widely used for treatment of cancer. over sixty ... | 2011 | 21743298 |
| traditional herbal antimalarial therapy in kilifi district, kenya. | to identify plant species used by the traditional health practitioners (thps) in treatment of malaria, carry out cytotoxicity and efficacy evaluation of the identified plants and to evaluate combination effects. | 2011 | 21211554 |
| the melanogenesis-inhibitory, anti-inflammatory, and chemopreventive effects of limonoids in n-hexane extract of azadirachta indica a. juss. (neem) seeds. | seventeen limonoids (tetranortriterpenoids 1-17) were isolated from the n-hexane extract of azadirachta indica (neem) seeds. the previously unidentified compound 16 was established by spectroscopy to be 17-defurano-17-oxosalannin. the effects of six compounds, 6 and 11-15, on melanogenesis in b16 melanoma cells was evaluated; 2 compounds, salannin (13) and 3-deacetylsalannin (15), exhibited marked inhibitory effects (70-74% reduction of melanin content at 25 µg/ml) with only minor cytotoxicity ( ... | 2011 | 21263200 |
| antioxidant activity of phenolic and flavonoid compounds in some medicinal plants of india. | in this study, total phenolics, flavonoids and vitamin c content vis-a-vis antioxidant activities were assayed in leaves and stem bark of azadirachta indica, butea monosperma, cassia fistula, mangifera indica, syzygium cumini and tamarindus indica using the 2,2-diphenyl-1-picrylhydrazyl (dpph) and superoxide radical scavenging method. the dpph radical scavenging activity positively correlated with the total phenolic content in both stem bark and leaf. superoxide radical scavenging activity incre ... | 2011 | 21726132 |
| effect of ficus sycomorus and azadirachta indica extracts on liver state of mice infected with schistosoma mansoni. | the potential role of hepatoprotective and antipathological effect of ficus sycomorus and azadirachta indica extracts was evaluated for scavenging the reactive oxygen species (ros) and reduced the oxidative damage and pathological changes in the liver of s. mansoni infected mice. the levels of alanine aminotransferase (alt), asparate aminotransferase (ast) and gamma glutamyl transferase (ggt) were evaluated in the infected mice and treated orally with each plant extract 12 weeks post infection ( ... | 2011 | 21634244 |
| ultrastructural analysis of the oocytes of female rhipicephalus sanguineus (latreille, 1806) (acari: ixodidae) ticks subjected to the action of azadirachta indica a. juss (neem). | the present study provides ultrastructural information about the acaricidal effects of neem (azadirachta indica a. juss) on the ovaries of r. sanguineus engorged females. in general, the main damage caused in the oocytes was alteration in the shape of the cell and of the germinal vesicle, ring-shaped nucleolus, cytoplasmic vacuolation, and disorganization of the organelles and of the cell membranes (including the chorion), all of which indicate that these cells could be in the process of death. ... | 2011 | 21981820 |
| in vitro and in vivo antiparasitic activity of azadirachtin against argulus spp. in carassius auratus (linn. 1758). | argulus is one of the most common and predominant ectoparasites which cause serious parasitic disease and is a potent carrier of viruses and bacteria in the ornamental fish industry. in recent years, organic (herbs)-based medicines are widely used to cure the disease, and neem (sarbaroganibarini) medicine is very popular and effective throughout the world. the present study was conducted to find the effects of azadirachtin against argulus spp. on carassius auratus under in vitro and in vivo cond ... | 2011 | 22042504 |
| ameliorative effects of ethanolic leaf extract of azadirachta indica on renal histologic alterations in streptozotocin-induced diabetic rats. | we studied the effect of ethanolic leaf extract of azadirachta indica (aie) on the microanatomy of the kidney of streptozotocin-induced diabetic rats. thirty male wistar rats (161-190 g) were randomly assigned to one of five treatment groups of six animals each: control, diabetic, diabetic + aie, diabetic + metformin, aie only. diabetes was induced with a single intraperitoneal dose of streptozotocin (70 mg/kg body weight). aie and metformin were administered orally for 50 days (50 d) at 500 mg/ ... | 2011 | 21905281 |
| anticoccidial activity of herbal complex in broiler chickens challenged with eimeria tenella. | summarythe objective of the present study was to evaluate the anticoccidial effect of different concentrations of the herbal complex of 4 plants (leaves of azadirachta indica and nicotiana tabacum, flowers of calotropis procera and seeds of trachyspermum ammi) in broiler chickens in comparison with amprolium anticoccidial. three concentrations (2 g, 4 g and 6 g) of herbal complex were given to the experimental groups once a day and amprolium (at the dose rate of 125 ppm) was given orally in drin ... | 2011 | 22018334 |
| removal of cadmium(ii) from wastewater using activated carbon prepared from agro industrial by-products. | removal of cadmium from wastewater using activated carbons prepared from cocos nucifera (coconut) and azadirachta indica (neem) oilcakes-an agricultural solid by-product was investigated. batch experiments were performed to evaluate the effect of ph, agitation time, initial metal ion concentration and adsorbent dose on the cadmium sorption in coconut oil cake activated carbon (cocac) and neem oil cake activated carbon (nocac). the experiments demonstrated that the adsorption process corresponds ... | 2011 | 23505814 |
| an integrated approach for the reduction of aflatoxin contamination in chilli (capsicum annuum l.). | an integrated approach for management of aflatoxin contamination in chilli was undertaken by evaluating the fungicides, bioagents and plant extracts against aspergillus flavus under both in vitro and field condition. maximum inhibition of radial growth (91.1%) was observed with 0.3% mancozeb followed by captan (85.2%). carbendazim (73%) was effective and superior over other systemic fungicides. a complete inhibition (100%) of a. flavus was observed in neem seed kernel extract (nske), nimbicidin ... | 2011 | 24425902 |
| aqueous extract of azadirachta indica (neem) leaf induces generation of reactive oxygen species and mitochondria-mediated apoptosis in rat oocytes. | present study was aimed to determine whether aqueous neem leaf extract (nle) induces generation of reactive oxygen species (ros) and apoptosis through mitochondria-mediated pathway in rat oocytes. | 2011 | 22089262 |
| in vitro azadirachtin production by hairy root cultivation of azadirachta indica in nutrient mist bioreactor. | azadirachtin, a well-known biopesticide is a secondary metabolite conventionally extracted from the seeds of azadirachta indica. the present study involved in vitro azadirachtin production by developing hairy roots of a. indica via agrobacterium rhizogenes-mediated transformation of a. indica explants. liquid culture of hairy roots was established in shake flask to study the kinetics of growth and azadirachtin production. a biomass production of 13.3 g/l dry weight (specific growth rate of 0.7 d ... | 2011 | 22083394 |
| anti-inflammatory, pro-apoptotic, and anti-proliferative effects of a methanolic neem (azadirachta indica) leaf extract are mediated via modulation of the nuclear factor-κb pathway. | azadirachta indica (neem tree) is used in traditional indian medicine for its pharmacological properties including cancer prevention and treatment. here, we studied a neem extract's anti-inflammatory potential via the nuclear factor-κb (nf-κb) signaling pathway, linked to cancer, inflammation, and apoptosis. cultured human leukemia cells were treated with a methanolic neem leaf extract with or without tumor necrosis factor (tnf)-α stimulation. inhibition of nf-κb activity was demonstrated by luc ... | 2011 | 21484152 |
| ovicidal effects of a neem seed extract preparation on eggs of body and head lice. | the eggs (nits) of head and body lice (pediculus humanus capitis, pediculus humanus corporis) were incubated for 5, 10, 15, 20, 30 or 45 min into a neem seed extract contained in a fine shampoo formulation (e.g. wash away® louse), which is known for its significant killing effects of larvae and adults of head lice. the aim of the study was to test whether the developmental stages inside the eggs are also killed after the incubation into the shampoo. it was found that an incubation time of only 5 ... | 2011 | 21484346 |
| trypanocidal potentials of azadirachta indica seeds against trypanosoma evansi. | the trypanocidal potentials of azadirachta indica seeds methanolic extract (nsme) against trypanosoma evansi was examined. in vitro studies with the nsme 100mg/ml, 50mg/ml and 25mg/ml immobilized the parasites within 3min, 8min and 14min respectively. in vivo experiments in infected rats at various dosage with nsme expressed transient ability of clearing the parasites in the infected blood. thin layer chromatographic (tlc) separations of the nsme gave 4 fractions in toluene and ethyl acetate [1: ... | 2011 | 21524857 |
| in vitro acaricidal activity of neem (azadirachta indica) seed extracts with known azadirachtin concentrations against rhipicephalus microplus. | the effect of four extracts from neem seeds (azadirachta indica) containing 2000, 5000, 9000 and 10,000ppm of azadirachtin a (aza), quantified by high-performance liquid chromatography (hplc) and diluted to 1.25%; 2.5%; 5.0%; 10.0% and 12.8% was verified by in vitro tests with engorged females and larvae of the cattle tick rhipicephalus microplus. the results from the bioassays with the engorged females showed that the main toxic effect of the extracts was reduction of the reproductive parameter ... | 2011 | 21536387 |
| azadirachta indica exerts chemopreventive action against murine skin cancer: studies on histopathological, ultrastructural changes and modulation of nf-kappab, ap-1, and stat1. | the present study reports the histopathological, ultrastructural changes and modulation of nf-kappab, ap-1, and stat 1 during skin carcinogenesis in laca mice and its intervention with azadirachta indica. skin tumors were induced by topical application of 7,12-dimethylbenz(a)anthracene (dmba) (500 nmol/100 microl for 2 weeks) followed by 12-o-tetradecanoylphorbol-13-acetate (tpa) (1.7 nmol/100 microl of acetone, twice weekly) as a promoter. male laca mice were divided into four groups: control, ... | 2011 | 21542454 |
| neem leaf glycoprotein inhibits cd4(+)cd25(+)foxp3(+) tregs to restrict murine tumor growth. | background: the presence of tregs in tumors is associated with compromised tumor-specific immune responses and has a clear negative impact on survival of cancer patients. thus, downregulation of tregs is considered as a promising cancer immunotherapeutic approach. we have reported previously that neem leaf glycoprotein (nlgp) prophylaxis restricts tumor growth in mice by immune activation. in continuation, here, involvement of nlgp in the modulation of tregs in association with tumor growth rest ... | 2011 | 21843083 |