Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| detection of human anti-zika virus igg by elisa using an antigen from in vitro infected vero cells: preliminary results. | zika virus (zkv) infection is a huge public health problem in brazil because of the increased incidence of microcephaly in neonates from infected mothers. detection of specific igg antibodies in maternal serum samples constitutes an important approach for diagnosing zkv infection and evaluating its relationship with neonatal microcephaly. however, as there is no serological test produced in brazil to detect igm and igg antibodies against zkv, we sought to examine specific igg in serum samples fr ... | 2016 | 27982355 |
| invasive mutualisms between a plant pathogen and insect vectors in the middle east and brazil. | complex multi-trophic interactions in vectorborne diseases limit our understanding and ability to predict outbreaks. arthropod-vectored pathogens are especially problematic, with the potential for novel interspecific interactions during invasions. variations and novelties in plant-arthropod-pathogen triumvirates present significant threats to global food security. we examined aspects of a phytoplasma pathogen of citrus across two continents. 'candidatus phytoplasma aurantifolia' causes witches' ... | 2016 | 28083099 |
| extended evaluation of virological, immunological and pharmacokinetic endpoints of celaden: a randomized, placebo-controlled trial of celgosivir in dengue fever patients. | celaden was a randomized placebo-controlled trial of 50 patients with confirmed dengue fever to evaluate the efficacy and safety of celgosivir (a study registered at clinicaltrials.gov, number nct01619969). celgosivir was given as a 400 mg loading dose and 200 mg bid (twice a day) over 5 days. replication competent virus was measured by plaque assay and compared to reverse transcription quantitative pcr (qpcr) of viral rna. pharmacokinetics (pk) correlations with viremia, immunological profiling ... | 2016 | 27509020 |
| co-infection of dengue fever and hepatitis a in a russian traveler. | we report a hepatitis a (hav) and dengue virus (denv) co-infection in russian man who had been traveling to dominican republic. at admission to the hospital hemorrhagic and jaundice symptoms were observed in patient. pcr tests of blood serum and urine revealed rna dengue virus type 3, hav rna, anti-hav-igm. | 2016 | 27516967 |
| storm drains as larval development and adult resting sites for aedes aegypti and aedes albopictus in salvador, brazil. | dengue (denv), chikungunya (chikv), zika (zikv), as well as yellow fever (yfv) viruses are transmitted to humans by aedes spp. females. in salvador, the largest urban center in north-eastern brazil, the four denv types have been circulating, and more recently, chikv and zikv have also become common. we studied the role of storm drains as aedes larval development and adult resting sites in four neighbourhoods of salvador, representing different socioeconomic, infrastructure and topographic condit ... | 2016 | 27464886 |
| neonatal encephalitis due to chikungunya vertical transmission: first report in brazil. | to report the first case of chikungunya encephalitis acquired in the perinatal period during the current outbreak in brazil. | 2016 | 27500084 |
| zika virus challenges for neuropsychiatry. | before 2007, zika virus (zikv) was generally considered as an arbovirus of low clinical relevance, causing a mild self-limiting febrile illness in tropical africa and southeast asia. currently, a large, ongoing outbreak of zikv that started in brazil in 2015 is spreading across the americas. virus infection during pregnancy has been potentially linked to congenital malformations, including microcephaly. in addition to congenital malformations, a temporal association between zikv infection and an ... | 2016 | 27478378 |
| dengue virus sero-cross-reactivity drives antibody-dependent enhancement of infection with zika virus. | zika virus (zikv) was discovered in 1947 and was thought to lead to relatively mild disease. the recent explosive outbreak of zikv in south america has led to widespread concern, with reports of neurological sequelae ranging from guillain barré syndrome to microcephaly. zikv infection has occurred in areas previously exposed to dengue virus (denv), a flavivirus closely related to zikv. here we investigated the serological cross-reaction between the two viruses. plasma immune to denv showed subst ... | 2016 | 27339099 |
| neuropathology of zika virus infection. | zika virus (zikv) is a member of the flaviviridae family that had been associated only with mild disease prior to the 2015 outbreak in brazil. a dramatic increase in reported cases of microcephaly and guillain-barré syndrome during this time prompted significant research into possible associations with zikv and its neurotropic properties. infection of neural progenitor cells and organoids have been shown to induce apoptosis and dysregulation of growth, and mouse studies have demonstrated viral r ... | 2016 | 27525286 |
| assessing seasonal risks for the introduction and mosquito-borne spread of zika virus in europe. | the explosive zika virus epidemic in the americas is amplifying spread of this emerging pathogen into previously unaffected regions of the world, including europe (gulland, 2016), where local populations are immunologically naïve. as summertime approaches in the northern hemisphere, aedes mosquitoes in europe may find suitable climatic conditions to acquire and subsequently transmit zika virus from viremic travellers to local populations. while aedes albopictus has proven to be a vector for the ... | 2016 | 27344225 |
| bioinformatic analysis reveals the expression of unique transcriptomic signatures in zika virus infected human neural stem cells. | the single-stranded rna flavivirus, zika virus (zikv), has recently re-emerged and spread rapidly across the western hemisphere's equatorial countries, primarily through aedes mosquito transmission. while symptoms in adult infections appear to be self-limiting and mild, severe birth defects, such as microcephaly, have been linked to infection during early pregnancy. recently, tang et al. (cell stem cell 2016, doi: 10.1016/j.stem.2016.02.016) demonstrated that zikv efficiently infects induced plu ... | 2016 | 27293547 |
| population genetics of the asian tiger mosquito aedes albopictus, an invasive vector of human diseases. | the asian tiger mosquito aedes albopictus is currently one of the most threatening invasive species in the world. native to southeast asia, the species has spread throughout the world in the past 30 years and is now present in every continent but antarctica. because it was the main vector of recent dengue and chikungunya outbreaks, and because of its competency for numerous other viruses and pathogens such as the zika virus, a. albopictus stands out as a model species for invasive diseases vecto ... | 2016 | 27273325 |
| the cellular bases of antibody responses during dengue virus infection. | dengue virus (denv) is one of the most significant human viral pathogens transmitted by mosquitoes and can cause from an asymptomatic disease to mild undifferentiated fever, classical dengue, and severe dengue. neutralizing memory antibody (ab) responses are one of the most important mechanisms that counteract reinfections and are therefore the main aim of vaccination. however, it has also been proposed that in dengue, some of these class-switched (igg) memory abs might worsen the disease. altho ... | 2016 | 27375618 |
| microcephaly in infants, pernambuco state, brazil, 2015. | we studied the clinical characteristics for 104 infants born with microcephaly in the delivery hospitals of pernambuco state, brazil, during 2015. testing is ongoing to exclude known infectious causes. however, microcephaly peaked in october and demonstrated central nervous system abnormalities with brain dysgenesis and intracranial calcifications consistent with an intrauterine infection. | 2016 | 27071041 |
| zika virus infection in 18 travellers returning from surinam and the dominican republic, the netherlands, november 2015-march 2016. | we report 18 cases of confirmed zika virus (zikv) infection in travellers returning to the netherlands from surinam (south america, bordering northern brazil) and the dominican republic. | 2016 | 27209175 |
| microbiota and neurological disorders: a gut feeling. | in the past century, noncommunicable diseases have surpassed infectious diseases as the principal cause of sickness and death, worldwide. trillions of commensal microbes live in and on our body, and constitute the human microbiome. the vast majority of these microorganisms are maternally derived and live in the gut, where they perform functions essential to our health and survival, including: digesting food, activating certain drugs, producing short-chain fatty acids (which help to modulate gene ... | 2016 | 27274912 |
| genetically modified (gm) mosquito use to reduce mosquito-transmitted disease in the us: a community opinion survey. | mosquito-borne infectious diseases such as dengue, chikungunya, and now zika, pose a public health threat to the us, particularly florida, the gulf coast states, and hawaii. recent autochthonous transmission of dengue and chikungunya in florida, the recent dengue outbreak in hawaii, and the potential for future local spread of zika in the us, has led to the consideration of novel approaches to mosquito management. one such novel approach, the release of sterile genetically modified mosquitoes, h ... | 2016 | 27366585 |
| increasing genetic diversity of zika virus in the latin american outbreak. | 2016 | 27381219 | |
| concern over zika virus outbreak: another alarming global threat. | zika virus, as highlighted by the world health organization in february 2016, has emerged as a public health emergency of international concern. zika virus is enveloped and icosahedral, and has a nonsegmented, single-stranded, positive-sense rna genome. it belongs to flaviviridae family. aedes aegypticus mosquito is the known vector. transmission is anthroponotic (human to vector to human) during outbreaks, or occurs perinatally in utero, sexually, and via transfusion of infected blood. zika vir ... | 2016 | 27418843 |
| complete coding sequence of zika virus from martinique outbreak in 2015. | zika virus is an aedes-borne flavivirus causing fever, arthralgia, myalgia rash, associated with guillain-barré syndrome and suspected to induce microcephaly in the fetus. we report here the complete coding sequence of the first characterized caribbean zika virus strain, isolated from a patient from martinique in december, 2015. | 2016 | 27274849 |
| predicting dengue fever outbreaks in french guiana using climate indicators. | dengue fever epidemic dynamics are driven by complex interactions between hosts, vectors and viruses. associations between climate and dengue have been studied around the world, but the results have shown that the impact of the climate can vary widely from one study site to another. in french guiana, climate-based models are not available to assist in developing an early warning system. this study aims to evaluate the potential of using oceanic and atmospheric conditions to help predict dengue f ... | 2016 | 27128312 |
| spread of the invasive mosquitoes aedes aegypti and aedes albopictus in the black sea region increases risk of chikungunya, dengue, and zika outbreaks in europe. | 2016 | 27115737 | |
| studies using ips cells support a possible link between zika and microcephaly. | there is a suspected link between brazilian babies born with microcephaly and zika virus (zikv) infection. however, little is know about the brain cell targets and the mechanisms that zika virus may cause microcephaly. a recent report demonstrated that zika virus infection increases cell death and dysregulates cell-cycle, resulting in attenuated human neural progenitor cells growth. this study fills a major gap and serves as an entry point to establish a mechanistic link between zika infection a ... | 2016 | 27119012 |
| zika virus outbreak in haiti in 2014: molecular and clinical data. | zika virus (zikv), first isolated in uganda in 1947, is currently spreading rapidly through south america and the caribbean. in brazil, infection has been linked with microcephaly and other serious complications, leading to declaration of a public health emergency of international concern; however, there currently are only limited data on the virus (and its possible sources and manifestations) in the caribbean. | 2016 | 27111294 |
| external quality assessment of dengue and chikungunya diagnostics in the asia pacific region, 2015. | to conduct an external quality assessment (eqa) of dengue and chikungunya diagnostics among national-level public health laboratories in the asia pacific region following the first round of eqa for dengue diagnostics in 2013. | 2016 | 27508088 |
| complete genome sequence of zika virus from the first imported case in mainland china. | the first case of zika virus infection was identified in a chinese traveler returning from venezuela in february 2016. this report describes the complete genome sequence of zika virus from the first imported case in china. the genome sequence analysis showed that the zika virus isolated in this case belongs to the asian lineage. | 2016 | 27103718 |
| the tree(s) of life: the human placenta and my journey to learn more about it. | 2016 | 27100178 | |
| the mitotic spindle: linking teratogenic effects of zika virus with human genetics? | recently, an association between zika virus infection and microcephaly/ocular findings was found to be reasonable e.g. because of the demonstration that the virus was found in the brain of a fetus after presumed maternal infection. although there is no proof yet for a causal relationship, for an appropriate risk calculation efforts are urgently needed to either establish or disprove this assumption. | 2016 | 27099632 |
| characterization of lethal zika virus infection in ag129 mice. | mosquito-borne zika virus (zikv) typically causes a mild and self-limiting illness known as zika fever, which often is accompanied by maculopapular rash, headache, and myalgia. during the current outbreak in south america, zikv infection during pregnancy has been hypothesized to cause microcephaly and other diseases. the detection of zikv in fetal brain tissue supports this hypothesis. because human infections with zikv historically have remained sporadic and, until recently, have been limited t ... | 2016 | 27093158 |
| microcephaly and zika virus: neonatal neuroradiological aspects. | the aim of this study is to describe some radiological features in the newborns with microcephaly caused by zika virus infection during pregnancy. | 2016 | 27080092 |
| clinical features and neuroimaging (ct and mri) findings in presumed zika virus related congenital infection and microcephaly: retrospective case series study. | to report radiological findings observed in computed tomography (ct) and magnetic resonance imaging (mri) scans of the first cases of congenital infection and microcephaly presumably associated with the zika virus in the current brazilian epidemic. | 2016 | 27075009 |
| zika virus focuses the gain-of-function debate. | 2016 | 27303723 | |
| mapping zika virus infection using geographical information systems in tolima, colombia, 2015-2016. | geographical information systems (gis) have been extensively used for the development of epidemiological maps of tropical diseases, however not yet specifically for zika virus (zikv) infection. | 2016 | 27134732 |
| global research trends of middle east respiratory syndrome coronavirus: a bibliometric analysis. | middle east respiratory syndrome coronavirus (mers-cov) is a virus that causes severe viral pneumonia in humans, known to have a high mortality rate and a similarity in clinical symptoms with severe acute respiratory syndrome coronavirus. it was first isolated in kingdom of saudi arabia (ksa) in 2012 and after that, mers-cov exhibited outbreaks in several regions of the world. this study aimed to assess the characteristics of publications involving mers-cov at global level by using a bibliometri ... | 2016 | 27267256 |
| zikv - cdb: a collaborative database to guide research linking sncrnas and zika virus disease symptoms. | in early 2015, a zika virus (zikv) infection outbreak was recognized in northeast brazil, where concerns over its possible links with infant microcephaly have been discussed. providing a causal link between zikv infection and birth defects is still a challenge. micrornas (mirnas) are small noncoding rnas (sncrnas) that regulate post-transcriptional gene expression by translational repression, and play important roles in viral pathogenesis and brain development. the potential for flavivirus-media ... | 2016 | 27332714 |
| genetic characterization of spondweni and zika viruses and susceptibility of geographically distinct strains of aedes aegypti, aedes albopictus and culex quinquefasciatus (diptera: culicidae) to spondweni virus. | zika virus (zikv) has extended its known geographic distribution to the new world and is now responsible for severe clinical complications in a subset of patients. while substantial genetic and vector susceptibility data exist for zikv, less is known for the closest related flavivirus, spondweni virus (sponv). both zikv and sponv have been known to circulate in africa since the mid-1900s, but neither has been genetically characterized by gene and compared in parallel. furthermore, the susceptibi ... | 2016 | 27783682 |
| three cases of zika virus imported in italy: need for a clinical awareness and evidence-based knowledge. | since early 2015, a large epidemic of zika virus (zikv) is spreading across south and central america. an association between congenital neurological malformations (mainly microcephaly), other neurological manifestations such as guillain-barrè syndrome, and zikv infection is suspected. | 2016 | 27835966 |
| increased hospitalizations for neuropathies as indicators of zika virus infection, according to health information system data, brazil. | evidence is increasing that zika virus can cause extensive damage to the central nervous system, affecting both fetuses and adults. we sought to identify traces of possible clinical manifestations of nervous system diseases among the registers of hospital admissions recorded in the brazilian unified health system. time series of several diagnoses from the international classification of diseases, 10th revision, were analyzed by using control diagrams, during january 2008-february 2016. beginning ... | 2016 | 27603576 |
| isolation of infective zika virus from urine and saliva of patients in brazil. | zika virus (zikv) is an emergent threat provoking a worldwide explosive outbreak. since january 2015, 41 countries reported autochthonous cases. in brazil, an increase in guillain-barré syndrome and microcephaly cases was linked to zikv infections. a recent report describing low experimental transmission efficiency of its main putative vector, ae. aegypti, in conjunction with apparent sexual transmission notifications, prompted the investigation of other potential sources of viral dissemination. ... | 2016 | 27341420 |
| dengue vaccine: considerations before rollout in colombia. | 2016 | 27280803 | |
| transmission dynamics of zika virus in island populations: a modelling analysis of the 2013-14 french polynesia outbreak. | between october 2013 and april 2014, more than 30,000 cases of zika virus (zikv) disease were estimated to have attended healthcare facilities in french polynesia. zikv has also been reported in africa and asia, and in 2015 the virus spread to south america and the caribbean. infection with zikv has been associated with neurological complications including guillain-barré syndrome (gbs) and microcephaly, which led the world health organization to declare a public health emergency of international ... | 2016 | 27186984 |
| phylogenetic analyses of chikungunya virus among travelers in rio de janeiro, brazil, 2014-2015. | chikungunya virus (chikv) is a mosquito-borne pathogen that emerged in brazil by late 2014. in the country, two chikv foci characterized by the east/central/south africa and asian genotypes, were established in north and northeast regions. we characterized, by phylogenetic analyses of full and partial genomes, chikv from rio de janeiro state (2014-2015). these chikv strains belong to the asian genotype, which is the determinant of the current northern brazilian focus, even though the genome sequ ... | 2016 | 27120007 |
| first imported case of chikungunya virus infection in a travelling canadian returning from the caribbean. | this is the first canadian case of chikungunya virus (chikv) infection reported in a traveller returning from the caribbean. following multiple mosquito bites in martinique island in january 2014, the patient presented with high fever, headaches, arthralgia on both hands and feet, and a rash on the trunk upon his return to canada. initial serological testing for dengue virus infection was negative. support therapy with nonsteroidal anti-inflammatory drugs was administered. the symptoms gradually ... | 2016 | 27366163 |
| aedes mosquitoes and zika virus infection: an a to z of emergence? | 2016 | 26905027 | |
| chikungunya: epidemiology. | chikungunya virus is a mosquito-borne alphavirus that causes fever and debilitating joint pains in humans. joint pains may last months or years. it is vectored primarily by the tropical and sub-tropical mosquito, aedes aegypti, but is also found to be transmitted by aedes albopictus, a mosquito species that can also be found in more temperate climates. in recent years, the virus has risen from relative obscurity to become a global public health menace affecting millions of persons throughout the ... | 2016 | 26918158 |
| zika vaccine misconceptions: a social media analysis. | 2016 | 27216759 | |
| a cost-effectiveness tool for informing policies on zika virus control. | as zika virus continues to spread, decisions regarding resource allocations to control the outbreak underscore the need for a tool to weigh policies according to their cost and the health burden they could avert. for example, to combat the current zika outbreak the us president requested the allocation of $1.8 billion from congress in february 2016. | 2016 | 27205899 |
| time to empower release of insects carrying a dominant lethal and wolbachia against zika. | ridl (release of insects with dominant lethality) and wolbachia are 2 potentially powerful tools in the fight against zika, but their technological advancement is being hampered by policy barriers. in this study, we discuss what could be done to overcome these regulatory deadlocks. | 2016 | 27419175 |
| toward a common secure future: four global commissions in the wake of ebola. | lawrence gostin and colleagues offer a set of priorities for global health preparedness and response for future infectious disease threats. | 2016 | 27195954 |
| estimated zika virus importations to europe by travellers from brazil. | given the interconnectivity of brazil with the rest of the world, zika virus (zikv) infections have the potential to spread rapidly around the world via viremic travellers. the extent of spread depends on the travel volume and the endemicity in the exporting country. in the absence of reliable surveillance data, we did mathematical modelling to estimate the number of importations of zikv from brazil into europe. | 2016 | 27193266 |
| personal protection of permethrin-treated clothing against aedes aegypti, the vector of dengue and zika virus, in the laboratory. | the dengue and zika viruses are primarily transmitted by aedes aegypti mosquitoes, which are most active during day light hours and feed both in and outside of the household. personal protection technologies such as insecticide-treated clothing could provide individual protection. here we assessed the efficacy of permethrin-treated clothing on personal protection in the laboratory. | 2016 | 27187593 |
| vertical transmission of zika virus targeting the radial glial cells affects cortex development of offspring mice. | the recent zika virus (zikv) epidemic in latin america coincided with a marked increase in microcephaly in newborns. however, the causal link between maternal zikv infection and malformation of the fetal brain has not been firmly established. here we show a vertical transmission of zikv in mice and a marked effect on fetal brain development. we found that intraperitoneal (i.p.) injection of a contemporary zikv strain in pregnant mice led to the infection of radial glia cells (rgs) of dorsal vent ... | 2016 | 27174054 |
| internet-based media coverage on dengue in sri lanka between 2007 and 2015. | internet-based media coverage to explore the extent of awareness of a disease and perceived severity of an outbreak at a national level can be used for early outbreak detection. dengue has emerged as a major public health problem in sri lanka since 2009. | 2016 | 27178645 |
| complete genome sequences of five zika virus isolates. | zika virus is an emerging human pathogen of great concern due to putative links to microcephaly and guillain-barre syndrome. here, we report the complete genomes, including the 5' and 3' untranslated regions, of five zika virus isolates, one from the asian lineage and four from the african lineage. | 2016 | 27174284 |
| the persistence and ecological impacts of a cyanobacterium genetically engineered to express mosquitocidal bacillus thuringiensis toxins. | the cyanobacterium anabaena pcc 7120#11 has been genetically engineered to act as a delivery vehicle for bacillus thuringiensis subspecies israelensis mosquitocidal toxins. to address ecological concerns about releasing this genetically engineered microorganism into the environment for mosquito larva control, the persistence and ecological impacts of pcc 7120#11 was evaluated using multi-species, standardized aquatic microcosms. | 2016 | 27165108 |
| the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine is a potent inhibitor of in vitro zika virus replication and delays disease progression in a robust mouse infection model. | zika virus (zikv) is an emerging flavivirus typically causing a dengue-like febrile illness, but neurological complications, such as microcephaly in newborns, have potentially been linked to this viral infection. we established a panel of in vitro assays to allow the identification of zikv inhibitors and demonstrate that the viral polymerase inhibitor 7-deaza-2'-c-methyladenosine (7dma) efficiently inhibits replication. infection of ag129 (ifn-α/β and ifn-γ receptor knock-out) mice with zikv res ... | 2016 | 27163257 |
| zika: what we know and don't know. | since the initial reports of a link between zika and microcephaly, researchers across the world began working toward understanding the virus. in a short amount of time, zika has become a household name, prompting worldwide concern. the virus is spread rapidly by mosquito bites. we currently do not have a vaccine for zika. but with the recent findings, vaccine companies are mobilizing their resources to expedite efforts to shave years off the typical decade-long process of vaccine development. | 2016 | 27583097 |
| zika virus, elevation, and transmission risk. | zika virus has appeared in the americas in the form of a major outbreak, and is now known to cause birth defects when pregnant women are infected. as a result, the centers for disease control and prevention issued travel guidelines, in the form of an elevational risk definition: destinations below 2000m are considered as at-risk. | 2016 | 27280061 |
| exploiting genetic interference for antiviral therapy. | rapidly evolving viruses are a major threat to human health. such viruses are often highly pathogenic (e.g., influenza virus, hiv, ebola virus) and routinely circumvent therapeutic intervention through mutational escape. error-prone genome replication generates heterogeneous viral populations that rapidly adapt to new selection pressures, leading to resistance that emerges with treatment. however, population heterogeneity bears a cost: when multiple viral variants replicate within a cell, they c ... | 2016 | 27149616 |
| a brief review of computer-assisted approaches to rational design of peptide vaccines. | the growing incidences of new viral diseases and increasingly frequent viral epidemics have strained therapeutic and preventive measures; the high mutability of viral genes puts additional strains on developmental efforts. given the high cost and time requirements for new drugs development, vaccines remain as a viable alternative, but there too traditional techniques of live-attenuated or inactivated vaccines have the danger of allergenic reactions and others. peptide vaccines have, over the las ... | 2016 | 27153063 |
| multi-country survey revealed prevalent and novel f1534s mutation in voltage-gated sodium channel (vgsc) gene in aedes albopictus. | aedes albopictus is an important dengue vector because of its aggressive biting behavior and rapid spread out of its native home range in southeast asia. pyrethroids are widely used for adult mosquito control, and resistance to pyrethroids should be carefully monitored because vector control is the only effective method currently available to prevent dengue transmission. the voltage-gated sodium channel gene is the target site of pyrethroids, and mutations in this gene cause knockdown resistance ... | 2016 | 27144981 |
| national public health law: a role for who in capacity-building and promoting transparency. | a robust health infrastructure in every country is the most effective long-term preparedness strategy for global health emergencies. this includes not only health systems and their human resources, but also countries' legal infrastructure for health: the laws and policies that empower, obligate and sometimes limit government and private action. the law is also an important tool in health promotion and protection. public health professionals play important roles in health law - from the developme ... | 2016 | 27429492 |
| wolbachia modulates lipid metabolism in aedes albopictus mosquito cells. | certain strains of the intracellular endosymbiont wolbachia can strongly inhibit or block the transmission of viruses such as dengue virus (denv) by aedes mosquitoes, and the mechanisms responsible are still not well understood. direct infusion and liquid chromatography-fourier transform ion cyclotron resonance (ft-icr) mass spectrometry-based lipidomics analyses were conducted using aedes albopictus aa23 cells that were infected with the wmel and wmelpop strains of wolbachia in comparison to un ... | 2016 | 26994075 |
| potential impact of sexual transmission on ebola virus epidemiology: sierra leone as a case study. | sexual transmission of ebola virus disease (evd) 6 months after onset of symptoms has been recently documented, and ebola virus rna has been detected in semen of survivors up to 9 months after onset of symptoms. as countries affected by the 2013-2015 epidemic in west africa, by far the largest to date, are declared free of ebola virus disease (evd), it remains unclear what threat is posed by rare sexual transmission events that could arise from survivors. | 2016 | 27135922 |
| larvicidal potential of the halogenated sesquiterpene (+)-obtusol, isolated from the alga laurencia dendroidea j. agardh (ceramiales: rhodomelaceae), against the dengue vector mosquito aedes aegypti (linnaeus) (diptera: culicidae). | dengue is considered a serious public health problem in many tropical regions of the world including brazil. at the moment, there is no viable alternative to reduce dengue infections other than controlling the insect vector, aedes aegypti linnaeus. in the continuing search for new sources of chemicals targeted at vector control, natural products are a promising alternative to synthetic pesticides. in our work, we investigated the toxicity of a bioactive compound extracted from the red alga laure ... | 2016 | 26821032 |
| anticipating the international spread of zika virus from brazil. | 2016 | 26777915 | |
| frozen funding on firearm research: "doing nothing is no longer an acceptable solution". | 2016 | 26823941 | |
| simultaneous outbreaks of dengue, chikungunya and zika virus infections: diagnosis challenge in a returning traveller with nonspecific febrile illness. | zika virus is an emerging flavivirus that is following the path of dengue and chikungunya. the three aedes-borne viruses cause simultaneous outbreaks with similar clinical manifestations which represents a diagnostic challenge in ill returning travellers. we report the first zika virus infection case imported to switzerland and present a diagnostic algorithm. | 2016 | 27006779 |
| zika virus infection: new threat in global health. | 2016 | 26955231 | |
| highly divergent dengue virus type 1 genotype sets a new distance record. | dengue viruses (denvs) are the leading cause of mosquito-borne viral disease of humans. they exist in both endemic and sylvatic ecotypes. in 2014, a viremic patient who had recently visited the rainforests of brunei returned to australia displaying symptoms consistent with denv infection. a unique denv strain was subsequently isolated from the patient, which we propose belongs to a new genotype within denv serotype 1 (denv-1). bayesian evolutionary phylogenetic analysis suggests that the putativ ... | 2016 | 26924208 |
| zika virus infection and stillbirths: a case of hydrops fetalis, hydranencephaly and fetal demise. | the rapid spread of zika virus in the americas and current outbreak of microcephaly in brazil has raised attention to the possible deleterious effects that the virus may have on fetuses. | 2016 | 26914330 |
| evaluating probabilistic dengue risk forecasts from a prototype early warning system for brazil. | recently, a prototype dengue early warning system was developed to produce probabilistic forecasts of dengue risk three months ahead of the 2014 world cup in brazil. here, we evaluate the categorical dengue forecasts across all microregions in brazil, using dengue cases reported in june 2014 to validate the model. we also compare the forecast model framework to a null model, based on seasonal averages of previously observed dengue incidence. when considering the ability of the two models to pred ... | 2016 | 26910315 |
| zika virus outbreak: 'a perfect storm'. | 2016 | 26956448 | |
| first complete genome sequence of zika virus (flaviviridae, flavivirus) from an autochthonous transmission in brazil. | we report here the genome sequence of zika virus, strain zikasph2015, containing all structural and nonstructural proteins flanked by the 5' and 3' untranslated region. it was isolated in são paulo state, brazil, in 2015, from a patient who received a blood transfusion from an asymptomatic donor at the time of donation. | 2016 | 26941134 |
| differential susceptibilities of aedes aegypti and aedes albopictus from the americas to zika virus. | since the major outbreak in 2007 in the yap island, zika virus (zikv) causing dengue-like syndromes has affected multiple islands of the south pacific region. in may 2015, the virus was detected in brazil and then spread through south and central america. in december 2015, zikv was detected in french guiana and martinique. the aim of the study was to evaluate the vector competence of the mosquito spp. aedes aegypti and aedes albopictus from the caribbean (martinique, guadeloupe), north america ( ... | 2016 | 26938868 |
| the expanding spectrum of modes of transmission of zika virus: a global concern. | 2016 | 26939897 | |
| zika virus in the americas: early epidemiological and genetic findings. | brazil has experienced an unprecedented epidemic of zika virus (zikv), with ~30,000 cases reported to date. zikv was first detected in brazil in may 2015, and cases of microcephaly potentially associated with zikv infection were identified in november 2015. we performed next-generation sequencing to generate seven brazilian zikv genomes sampled from four self-limited cases, one blood donor, one fatal adult case, and one newborn with microcephaly and congenital malformations. results of phylogene ... | 2016 | 27013429 |
| an overview of zika virus disease. | 2016 | 27366289 | |
| possible repurposing of seasonal influenza vaccine for prevention of zika virus infection. | the in silico analysis shows that the envelope glycoproteins e of zika viruses (zikv) isolated in asia, africa and south and central america encode highly conserved information determining their interacting profile and immunological properties. previously it was shown that the same information is encoded in the primary structure of the hemagglutinin subunit 1 (ha1) from pdmh1n1 influenza a virus. this similarity suggests possible repurposing of the seasonal influenza vaccine containing pdmh1n1 ... | 2016 | 27158449 |
| virological factors that increase the transmissibility of emerging human viruses. | the early detection of pathogens with epidemic potential is of major importance to public health. most emerging infections result in dead-end "spillover" events in which a pathogen is transmitted from an animal reservoir to a human but is unable to achieve the sustained human-to-human transmission necessary for a full-blown epidemic. it is therefore critical to determine why only some virus infections are efficiently transmitted among humans whereas others are not. we sought to determine which b ... | 2016 | 27001840 |
| zika virus and neurologic autoimmunity: the putative role of gangliosides. | an increasing number of severe neurological complications associated with zika virus (zikv), chiefly guillain-barré syndrome (gbs) and primary microcephaly, have led the world health organization to declare a global health emergency. molecular mimicry between glycolipids and surface molecules of infectious agents explain most of the cases of gbs preceded by infection, while a direct toxicity of zikv on neural cells has been raised as the main mechanism by which zikv induces microcephaly. ganglio ... | 2016 | 27001187 |
| the zika pandemic - a perfect storm? | 2016 | 26991663 | |
| zika: structuring the european research response. | studies are needed to assess #zika virus risks and to develop diagnostic tests http://ow.ly/zaozw. | 2016 | 27730165 |
| modelling population dynamics in realistic landscapes with linear elements: a mechanistic-statistical reaction-diffusion approach. | we propose and develop a general approach based on reaction-diffusion equations for modelling a species dynamics in a realistic two-dimensional (2d) landscape crossed by linear one-dimensional (1d) corridors, such as roads, hedgerows or rivers. our approach is based on a hybrid "2d/1d model", i.e, a system of 2d and 1d reaction-diffusion equations with homogeneous coefficients, in which each equation describes the population dynamics in a given 2d or 1d element of the landscape. using the exampl ... | 2016 | 26986201 |
| financing and collaboration on research and development for nodding syndrome. | nodding syndrome is a neurological disease with no known cure or treatment, impacting children aged 3-18 years old, mainly in east africa. children progressively develop varying degrees of cognitive impairment which may lead to severe wasting, a vegetative state and, eventually, death. despite its 50-year existence, little is known about its cause, risk factors and prognosis. it is a disease where markets will not provide solutions because the patients are both too few and too poor, making it es ... | 2016 | 26983551 |
| association between zika virus and microcephaly in french polynesia, 2013-15: a retrospective study. | the emergence of zika virus in the americas has coincided with increased reports of babies born with microcephaly. on feb 1, 2016, who declared the suspected link between zika virus and microcephaly to be a public health emergency of international concern. this association, however, has not been precisely quantified. | 2016 | 26993883 |
| on the seasonal occurrence and abundance of the zika virus vector mosquito aedes aegypti in the contiguous united states. | an ongoing zika virus pandemic in latin america and the caribbean has raised concerns that travel-related introduction of zika virus could initiate local transmission in the united states (u.s.) by its primary vector, the mosquito aedes aegypti. | 2016 | 27066299 |
| zika virus: more questions than answers. | 2016 | 27077095 | |
| the genetic basis of host preference and resting behavior in the major african malaria vector, anopheles arabiensis. | malaria transmission is dependent on the propensity of anopheles mosquitoes to bite humans (anthropophily) instead of other dead end hosts. recent increases in the usage of long lasting insecticide treated nets (llins) in africa have been associated with reductions in highly anthropophilic and endophilic vectors such as anopheles gambiae s.s., leaving species with a broader host range, such as anopheles arabiensis, as the most prominent remaining source of transmission in many settings. an. arab ... | 2016 | 27631375 |
| rerouting biomedical innovation: observations from a mapping of the alternative research and development (r&d) landscape. | in recent years, the world has witnessed the tragic outcomes of multiple global health crises. from ebola to high prices to antibiotic resistance, these events highlight the fundamental constraints of the current biomedical research and development (r&d) system in responding to patient needs globally.to mitigate this lack of responsiveness, over 100 self-identified "alternative" r&d initiatives, have emerged in the past 15 years. to begin to make sense of this panoply of initiatives working to o ... | 2016 | 27627882 |
| bacterial larvicide, bacillus thuringiensis israelensis strain am 65-52 water dispersible granule formulation impacts both dengue vector, aedes aegypti (l.) population density and disease transmission in cambodia. | a multi-phased study was conducted in cambodia from 2005-2011 to measure the impact of larviciding with the bacterial larvicide, bacillus thuringiensis israelensis (bti), a water dispersible granule (wg) formulation on the vector, aedes aegypti (l.) and the epidemiology. in our studies, all in-use containers were treated at 8 g/1000 l, including smaller containers and animal feeders which were found to contribute 23% of ae aegypti pupae. the treated waters were subjected to routine water exchang ... | 2016 | 27627758 |
| zika: an old virus with a new face. | zika virus is a mosquito-borne flavivirus that represents a public health emergency at the ongoing epidemic. this obscure virus was limited to sporadic cases in africa and asia, until the emergence of zika virus in brazil in 2015, when it rapidly spread throughout the americas. most zika virus infections are subclinical or characterized by mild febrile illness. however, neurological complications, including guillain-barré syndrome in adults, and congenital anomalies, including microcephaly in ba ... | 2016 | 27703544 |
| understanding ebola: the 2014 epidemic. | near the end of 2013, an outbreak of zaire ebolavirus (ebov) began in guinea, subsequently spreading to neighboring liberia and sierra leone. as this epidemic grew, important public health questions emerged about how and why this outbreak was so different from previous episodes. this review provides a synthetic synopsis of the 2014-15 outbreak, with the aim of understanding its unprecedented spread. we present a summary of the history of previous epidemics, describe the structure and genetics of ... | 2016 | 27624088 |
| population surveillance for microcephaly. | 2016 | 27623958 | |
| prevalence of microcephaly in europe: population based study. | to provide contemporary estimates of the prevalence of microcephaly in europe, determine if the diagnosis of microcephaly is consistent across europe, and evaluate whether changes in prevalence would be detected using the current european surveillance performed by eurocat (the european surveillance of congenital anomalies). | 2016 | 27623840 |
| with great power comes great responsibility-a personal philosophy for communicating science in society. | many think that communicating science is a necessary and rewarding activity. yet finding compelling, relevant, and timely points of linkage between challenging scientific concepts and the experiences and interests of the general public can be difficult. since science continues to influence more and more aspects of daily life and knowledge, there is a parallel need for communication about science in our society. here i discuss the "middle-ground hypothesis" using popular culture for science commu ... | 2016 | 27642632 |
| isolation of zika virus imported from tonga into australia. | the globally emergent zika virus (zikv) is a threat to australia, given the number of imported cases from epidemic regions and the presence of competent mosquito vectors. we report the isolation of zikv from a female traveler who recently returned from tonga to brisbane, queensland, australia in 2016. | 2016 | 27679739 |
| infectious diseases epidemic threats and mass gatherings: refocusing global attention on the continuing spread of the middle east respiratory syndrome coronavirus (mers-cov). | media and world health organization (who) attention on zika virus transmission at the 2016 rio olympic games and the 2015 ebola virus outbreak in west africa diverted the attention of global public health authorities from other lethal infectious diseases with epidemic potential. mass gatherings such as the annual hajj pilgrimage hosted by kingdom of saudi arabia attract huge crowds from all continents, creating high-risk conditions for the rapid global spread of infectious diseases. the highly l ... | 2016 | 27604081 |
| zika virus infection in mice causes panuveitis with shedding of virus in tears. | zika virus (zikv) is an emerging flavivirus that causes congenital abnormalities and guillain-barré syndrome. zikv infection also results in severe eye disease characterized by optic neuritis, chorioretinal atrophy, and blindness in newborns and conjunctivitis and uveitis in adults. we evaluated zikv infection of the eye by using recently developed mouse models of pathogenesis. zikv-inoculated mice developed conjunctivitis, panuveitis, and infection of the cornea, iris, optic nerve, and ganglion ... | 2016 | 27612415 |
| complete genome sequences of three historically important, spatiotemporally distinct, and genetically divergent strains of zika virus: mr-766, p6-740, and prvabc-59. | here, we report the 10,807-nucleotide-long consensus rna genome sequences of three spatiotemporally distinct and genetically divergent zika virus strains, with the functionality of their genomic sequences substantiated by reverse genetics: mr-766 (african lineage, uganda, 1947), p6-740 (asian lineage, malaysia, 1966), and prvabc-59 (asian lineage-derived american strain, puerto rico, 2015). | 2016 | 27540058 |