Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| kaposi's sarcoma-associated herpesvirus contains g protein-coupled receptor and cyclin d homologs which are expressed in kaposi's sarcoma and malignant lymphoma. | a new human herpesvirus was recently identified in all forms of kaposi's sarcoma (kaposi's sarcoma-associated herpesvirus [kshv] or human herpesvirus 8), as well as in primary effusion (body cavity-based) lymphomas (pels). a 12.3-kb-long kshv clone was obtained from a pel genomic library. sequencing of this clone revealed extensive homology and colinearity with the right end of the herpesvirus saimiri (hvs) genome and more limited homology to the left end of the epstein-barr virus genome. four o ... | 1996 | 8892957 |
| overview of the management of aids-related kaposi's sarcoma. | to review the epidemiology, pathogenesis, clinical presentation, diagnosis, and staging of kaposi's sarcoma (ks), as well as the current role of local and systemic therapies in the management of aids-related ks (aids-ks). | 1996 | 8893123 |
| posttransplant t-cell lymphoproliferative disorders--an aggressive, late complication of solid-organ transplantation. | t-cell non-hodgkin's lymphomas are an uncommon occurrence after solid-organ transplantation. we describe a morphologically and immunophenotypically distinct group of t-cell lymphoproliferative disorders that occurred late in the course of six patients with solid-organ transplants. the patients ranged in age from 31 to 56 years (median, 43). three were male; all were splenectomized. the interval from transplant to the diagnosis of lymphoma ranged from 4 to 26 years (median, 15). symptoms at prese ... | 1996 | 8896433 |
| increases in cd3+cd4-cd8- t lymphocytes in aids patients with disseminated mycobacterium avium-intracellulare complex infection. | human immunodeficiency virus type 1 (hiv-1)-infected persons frequently have increased numbers of t cells bearing the gamma delta t cell receptor for antigen (gamma delta tcr). hiv-1-seropositive patients with < 100 cd4+ cells/mm3 were selected and divided into 9 aids-defining illness groups. the percentages of cd4+, cd8+, or double-negative cd4-cd8- (dn) t cells (most of the latter expressing the gamma delta tcr) for 8 symptomatic groups were compared with those for a reference group of asympto ... | 1996 | 8896497 |
| human herpesvirus type 8 dna sequences in cell-free plasma and mononuclear cells of kaposi's sarcoma patients. | human herpesvirus (hhv) type 8 has been detected in both classical and aids-related kaposi's sarcoma, body-cavity lymphomas, and other types of tumors. hhv-8 has also been detected in dna from peripheral blood mononuclear cells (pbmc) of some kaposi's sarcoma patients and more readily in b cell fractions derived from panned cell subpopulations. two patients were followed using several methods; in situ hybridization, solution-based polymerase chain reaction (pcr), and in situ pcr. hhv-8 was inter ... | 1996 | 8896516 |
| the natural history and molecular heterogeneity of hiv-associated primary malignant lymphomatous effusions. | primary malignant lymphomatous effusions arising in individuals infected with the human immunodeficiency virus, type 1 (hiv-1) represent a rare subset of hiv-associated lymphomas. previous studies have demonstrated that the malignant cells are monoclonal (as defined by rearrangement of the immunoglobulin gene), express cell surface cd38, and are infected with epstein-barr virus (ebv) and human herpes virus, type 8 (hhv-8). despite these detailed molecular and immunophenotypic studies, clinical i ... | 1996 | 8898666 |
| hhv-8: a new herpesvirus associated with kaposi's sarcoma. | kaposi's sarcoma (ks) is a multifocal neoplasm that develops in a high proportion of hiv-infected homosexual men. ks lesions contain novel herpes-like dna sequences (hhv-8), and recent studies characterizing hhv-8 and its association with ks, and with other diseases, suggest that hhv-8 may represent the etiological viral pathogen. | 1996 | 8899963 |
| [human herpesviruses 6 and 7]. | by new methods for propagating cells of the immune system and for detecting infectious agents in disease tissue, 4 human herpesviruses have been discovered during the past decade: human herpesvirus 6 variants a and b (hhv-6a and hhv-6b), human herpesvirus 7 (hhv-7), and human herpesvirus 8 (hhv-8). only hhv-8 has been linked to a disease that might be described as new, that is aids-associated kaposi's sarcoma. no disease has been clearly linked to hhv-6a infection, hhv-6b is the major etiologic ... | 1996 | 8911066 |
| increased incidence of cancer among homosexual men, new york city and san francisco, 1978-1990. | several studies have shown that human immunodeficiency virus type 1 (hiv-1) is associated with an increase in the incidence of kaposi's sarcoma and non-hodgkin's lymphoma among homosexual men. the role of hiv-1 in increasing the incidence of other malignancies is more controversial. the incidence of non-kaposi's sarcoma cancer was examined from 1978 to 1990 among 15,565 homosexual men who participated in studies of hepatitis b virus infection in the late 1970s in new york city, new york, and san ... | 1996 | 8916502 |
| short report: herpes-like dna sequences in african-endemic and acquired immunodeficiency syndrome-associated kaposi's sarcoma. | recently, the unique nucleic acid closely related to the herpes-like sequences has been found in acquired immunodeficiency syndrome (aids)-associated kaposi's sarcoma (ks). we have confirmed the presence of herpes-like dna sequences in six cases of aids-associated ks and three of the nine cases of african-endemic ks in adults, but not in eight cases of ks in children from the same area. these sequences were seen in a histologically early stage of ks. our results suggest that herpes-like dna sequ ... | 1996 | 8916796 |
| multicentric castleman's disease in hiv infection: a clinical and pathological study of 20 patients. | to describe, in a retrospective study, the clinical and pathological spectrum of multicentric castleman's disease (mcd) in hiv infection. | 1996 | 8924253 |
| [current aspects of kaposi sarcoma virus]. | 1996 | 8927899 | |
| kaposi's sarcoma-associated herpesvirus in kaposi's sarcoma occurring in immunosuppressed renal transplant recipients. | kaposi's sarcoma-associated herpesvirus (kshv) has been implicated in the genesis of kaposi's sarcoma and other tumors occurring in immunosuppressed individuals. using amplification by the polymerase chain reaction and nucleotide sequencing of extracted dna, we have detected the ks330(233) sequence of kshv dna in kaposi's sarcoma tissue from 4 immunosuppressed renal transplant recipients. the sequences shared a greater than 98% homology with those described in kshv dna from kaposi's sarcoma in p ... | 1996 | 8930456 |
| the sex ratio of aids-associated kaposi's sarcoma does not provide evidence that sex hormones play a role in pathogenesis. | 1996 | 8931798 | |
| detection of kaposi's sarcoma herpesvirus dna in semen of homosexual men with kaposi's sarcoma. | 1996 | 8931799 | |
| lack of evidence of hhv-8 in mature t-cell lymphoproliferative disorders. | 1996 | 8937299 | |
| molecular mimicry of human cytokine and cytokine response pathway genes by kshv. | four virus proteins similar to two human macrophage inflammatory protein (mip) chemokines, interleukin-6 (il-6), and interferon regulatory factor (irf) are encoded by the kaposi's sarcoma-associated herpesvirus (kshv) genome. vil-6 was functional in b9 proliferation assays and primarily expressed in kshv-infected hematopoietic cells rather than ks lesions. hiv-1 transmission studies showed that vmip-i is similar to human mip chemokines in its ability to inhibit replication of hiv-1 strains depen ... | 1996 | 8939871 |
| kaposi's sarcoma and herpesvirus 8: a word of caution. | 1996 | 8944361 | |
| laryngeal kaposi's sarcoma in patients with aids. | over a period of 10 years 17 human immunodeficiency virus(hiv)-infected patients with laryngeal kaposi's sarcoma were seen and treated at university college london hospitals. all patients had advanced hiv disease. their presentation was with symptoms of upper airway obstruction in the majority of cases and the diagnosis was made by fibreoptic examination of the larynx. biopsy was associated with brisk haemorrhage in one patient, who required a temporary tracheostomy, and was not performed in the ... | 1996 | 8944878 |
| the angiogenesis induced by hiv-1 tat protein is mediated by the flk-1/kdr receptor on vascular endothelial cells. | the hiv-1 tat protein transactivates hiv, viral and some host cell genes. tat can be released by infected cells and acts extracellularly in the microenvironment, regulating functions of immunocompetent and mesenchymal cells. one of the most striking effects of tat is the induction of a functional program in vascular cells related to angiogenesis and inflammation (migration, proliferation and expression of plasminogen activator inhibitor-1 and e selectin). tat induces growth of kaposi's sarcoma ( ... | 1996 | 8946838 |
| kaposi's sarcoma: evaluation of the role of human papillomaviruses. a study using the high sensitivity hot-start polymerase chain reaction detection method and a review of the literature. | 1996 | 8950462 | |
| kaposi's sarcoma and hhv-8. | 1996 | 8950809 | |
| hhv-8 serology and kaposi's sarcoma. | 1996 | 8950901 | |
| aortic endothelium in hiv-1 infection: chronic injury, activation, and increased leukocyte adherence. | clinical and serological studies provide evidence for a pathogenetically relevant vasculopathy in acquired immune deficiency syndrome (aids); however, the morphological status of the endothelium under conditions of human immunodeficiency virus (hiv)-1 infection is only sparsely documented. in this study we adapted an en face preparation technique of endothelium for use in immunohistochemistry and investigated the aortic endothelium of pre-aids and aids patients (n = 32) in comparison with an hiv ... | 1996 | 8952525 |
| efficacy of antitat gene therapy in the presence of high multiplicity infection and inflammatory cytokines. | because human immunodeficiency virus type 1 (hiv-1) infection is characterized by a large number of viral replication cycles and rapid cell turnover in vivo, successful gene therapy requires an approach effective under these conditions. the antitat gene has been proposed for gene therapy because it effectively blocks tat function and the replication of hiv-1. however, neither antitat nor any other antiviral gene has been shown to inhibit hiv in the presence of high viral load and inflammatory cy ... | 1996 | 8953311 |
| nucleotide sequence of the kaposi sarcoma-associated herpesvirus (hhv8). | the genome of the kaposi sarcoma-associated herpesvirus (kshv or hhv8) was mapped with cosmid and phage genomic libraries from the bc-1 cell line. its nucleotide sequence was determined except for a 3-kb region at the right end of the genome that was refractory to cloning. the bc-1 kshv genome consists of a 140.5-kb-long unique coding region flanked by multiple g + c-rich 801-bp terminal repeat sequences. a genomic duplication that apparently arose in the parental tumor is present in this cell c ... | 1996 | 8962146 |
| absence of herpesvirus in aids-associated smooth-muscle tumors. | 1996 | 8965873 | |
| hiv-1 and kaposi's sarcoma. | 1996 | 8972281 | |
| multicentric angiofollicular lymph node hyperplasia in children: a clinicopathologic study of eight patients. | multicentric angiofollicular lymph node hyperplasia (mafh) is an idiopathic systemic disorder that has been reported only rarely in children. therefore, we reviewed the clinical and pathologic features of eight patients listed in the angiofollicular lymph node hyperplasia registry at our institution. the ages of the patients ranged from two to 17 years (median, 10 yr), and the male-to-female ratio was 1:3. the patients presented with constitutional symptoms, multifocal lymphadenopathy, hepatomeg ... | 1996 | 8972472 |
| absence of kaposi's sarcoma-associated herpesvirus-like dna sequences in malignant vascular tumors of the serous membranes. | reports connect kaposi's sarcoma-associated herpesvirus (kshv) with various types of kaposi's sarcoma (ks) and body-cavity-based lymphomas (primary effusion lymphomas). kshv dna sequences have also been detected in a few non-ks malignant vascular tumors. to determine whether kshv is associated with malignant vascular tumors involving the body cavities, 11 primary vascular tumors of the serous membranes (4 angiosarcomas, 7 hemangioendotheliomas) were tested for kshv sequences by polymerase chain ... | 1996 | 8972473 |
| kaposi's sarcoma-associated herpesvirus (kshv) sequences in premalignant and malignant skin tumors. | the novel herpesvirus-like dna sequences, which were identified in aids-related kaposi's sarcoma (ks) and designated ks associated herpesvirus (kshv) or human herpesvirus 8 (hhv-8), have been reported to be associated with various forms of ks. here, we searched for the presence of kshv sequences in various other skin lesions including premalignant or malignant skin tumors of a total of 69 clinical cases without immunodeficiency due to aids or following organ transplantation. strikingly high rate ... | 1996 | 8973535 |
| distribution of human herpesvirus-8 sequences throughout the spectrum of aids-related neoplasia. | aids frequently associates with certain malignancies, including kaposi's sarcoma, non-hodgkin's lymphoma (nhl), and anogenital neoplasia. in this study we aimed to define the frequency of infection by human herpesvirus (hhv)-8 throughout the spectrum of aids-related neoplasia in europe. | 1996 | 8853726 |
| oral manifestations associated with human immunodeficiency virus infection in a spanish population. | a study was made of the oral manifestations in 396 patients with human immunodeficiency virus (hiv) infection. the following risk groups were established: intravenous drug users (79.5%), homosexuals (7.8%), homosexual intravenous drug users (3.3%), heterosexuals (8.1%) and hemophiliacs/transfusion patients (1.3%). the oral lesions, in decreasing order of frequency, were: periodontal disease (78.28%), candidiasis (65.65%), hairy leukoplakia (16.16%), herpes simplex virus lesions (5.30%). kaposi's ... | 1996 | 8986962 |
| kaposi's sarcoma-associated herpesvirus infection prior to onset of kaposi's sarcoma. | kaposi's sarcoma-associated herpesvirus (kshv), a newly discovered human gammaherpesvirus, is found in the majority of ks lesions from patients with and without aids. peripheral blood mononuclear cells (pbmc) were examined for kshv dna to determine whether viral infection precedes onset of this neoplasm. | 1996 | 8838705 |
| establishment and characterization of a primary effusion (body cavity-based) lymphoma cell line (bc-3) harboring kaposi's sarcoma-associated herpesvirus (kshv/hhv-8) in the absence of epstein-barr virus. | the recently identified kaposi's sarcoma-associated herpesvirus (kshv), also known as human herpesvirus 8 (hhv-8), has been found to be consistently associated with an unusual subset of acquired immunodeficiency syndrome-related lymphomas, the so-called body cavity-based lymphomas (bcbl) or primary effusion lymphomas (pel). these lymphomas are characterized by a unique spectrum of morphologic and molecular characteristics, and grow as lymphomatous effusions without an identifiable contiguous tum ... | 1996 | 8839859 |
| kaposi's sarcoma herpesvirus-like dna sequences in the saliva of individuals infected with human immunodeficiency virus. | 1996 | 8842293 | |
| antibodies to human herpesvirus type 8 in the general population and in kaposi's sarcoma patients. | much of the evidence that human herpesvirus type 8 (hhv-8) is associated with kaposi's sarcoma (ks) has come from molecular studies of hhv-8 dna. seroepidemiological studies have been hampered by the lack of a reliable assay. | 1996 | 8826812 |
| viruses in the pathogenesis of kaposi's sarcoma--a review. | kaposi's sarcoma (ks) is the most frequent malignancy in aids patients. epidemiological studies indicate that a sexually transmitted infections agent other than hiv is involved in the evolution of ks. this "ks agent" may induce a cascade of cytokines which promote the development of the tumor in an autocrine and paracrine mechanism. in this review article several viruses, especially the recently discovered kaposi's sarcoma herpesvirus (kshv or hhv-8), are discussed as possible ks agents, and dif ... | 1996 | 8809339 |
| pathogenesis of aids--related kaposi's sarcoma. | the occurrence of kaposi's sarcoma (ks) in patients with hiv infection is more than 7,000 times higher than in the non-hiv infected population. the reason for this association is unclear but may involve decreased immune surveillance as a result of the profound cellular immune deficiency caused by hiv, a sexually transmitted ks-inducing virus, whose ks-transforming capabilities may be enhanced by hiv, or a direct or indirect effect of hiv itself in susceptible individuals. over the last few years ... | 1996 | 8820448 |
| autopsy findings in patients with human immunodeficiency virus infection with emphasis on the risk factor of hemophilia. | the autopsy findings of 80 human immunodeficiency virus (hiv)-infected adults, who died between 1982-1995, are presented with special emphasis on the risk factor of hemophilia. the study included 23 blood product recipients (hemophiliacs n = 21; non-hemophiliacs n = 2), 34 homosexuals, four intravenous drug abusers, and 19 patients with no known risk factor. nearly all individuals (93%) showed the late stage of acquired immunodeficiency syndrome (aids). blood product recipients had a significant ... | 1996 | 8780928 |
| the role of human herpesvirus 8 and epstein-barr virus in the pathogenesis of giant lymph node hyperplasia (castleman's disease). | 1996 | 8783733 | |
| kaposi's sarcoma-associated herpesvirus dna sequences in aids-related and aids-unrelated lymphomatous effusions. | primary effusions presenting as the sole lymphoma localization are also known as body-cavity-based-lymphoma (bcbl), and have been shown to carry kaposi's sarcoma herpesvirus (kshv) dna sequences. the aim of this study was a comparative analysis of the clinical, pathologic and molecular features of bcbl and lymphomatous effusions secondary to tissue-based lymphomas occurring both in the general population and in hiv-1-infected individuals. all the lymphomatous effusion samples (seven aids-related ... | 1996 | 8790156 |
| a bivariate parametric model for survival and intermediate event times. | in diseases such as acquired immune deficiency syndrome (aids), there is great interest in describing the frequency of secondary diagnoses that occur during the course of the disease and their effect on survival. casting this situation in a more general framework, one distinguishes a terminal event (te) and an intermediate event (ie) that may or may not occur. in epidemiologic applications the te is usually death. earlier studies of ie and te times have used the latter to censor the ie time for ... | 1996 | 8804146 |
| kaposi's sarcoma with an intense parasitization by leishmania. | visceral leishmaniasis has been reported as a complication in patients infected with human immunodeficiency virus (hiv) who live in areas where leishmaniasis is endemic or in patients who have traveled to these areas. kaposi's sarcoma has been found frequently in patients with acquired immunodeficiency syndrome (aids). we report a hiv-infected patient having visceral leishmaniasis associated with kaposi's sarcoma in which a biopsy specimen obtained from a pigmented cutaneous lesion revealed the ... | 1996 | 8646853 |
| latent bk virus infection and kaposi's sarcoma pathogenesis. | we have analyzed by pcr skin lesions from classic, endemic and aids-related kaposi's sarcoma (ks), as well as from ks-derived cell lines, the presence of ubiquitous transforming viruses. bk virus (bkv), a transforming human papovavirus which has been associated with human tumors, was detected in 100% of ks skin lesions and 75% of ks cell lines. ks specimens contained a full-length, intact bkv early region, but minor rearrangements were observed in some tumors. bkv was also detected with a high p ... | 1996 | 8647638 |
| use of antiherpes drugs and the risk of kaposi's sarcoma: data from the multicenter aids cohort study. | to determine if use of antiherpes drugs protects against the development of aids-associated kaposi's sarcoma (ks), data from 935 homosexual men with aids from the multicenter aids cohort study were analyzed. in nested case-control analysis, neither acyclovir use for human immunodeficiency virus infection (odds ratio [or], 0.84; 95% confidence interval [ci], 0.56-1.26; p = .39) nor acyclovir use for any indication (or, 1.02; 95% ci, 0.76-1.38; p = .89) was associated with a reduced risk of ks as ... | 1996 | 8648224 |
| kaposi's sarcoma-associated herpesvirus (kshv or hhv8) in primary effusion lymphoma: ultrastructural demonstration of herpesvirus in lymphoma cells. | recent molecular evidence suggests an association with a new herpesvirus, kaposi's sarcoma-associated herpesvirus (kshv/hhv-8), and primary effusion lymphomas (pels). pels have a characteristic morphology, phenotype, and clinical presentation, with malignant effusions in the absence of a contiguous solid tumor mass. we have established a cell line (ks-1) from a kshv-positive human immunodeficiency virus (hiv)-negative patient with pleural cavity-based lymphoma that was passaged into triple-immun ... | 1996 | 8652805 |
| kaposi's sarcoma in childhood: an analysis of 100 cases from uganda and relationship to hiv infection. | we report 100 cases of kaposi's sarcoma (ks) in children under 15 years of age treated at the uganda cancer institute in the 6-year period 1989-1994. the incidence of childhood ks has risen more than 40-fold in the era of aids, and 78% of 63 cases tested were seropositive for hiv-1. there were 63 boys and 37 girls. the median age was 4 years and the median age of onset was 33 months. tumour distribution was lymphadenopathic and muco-cutaneous, with 2 major patterns: pattern i, oro-facial dominan ... | 1996 | 8567117 |
| kaposi's sarcoma-associated herpesvirus and kaposi's sarcoma in africa. uganda kaposi's sarcoma study group. | endemic kaposi's sarcoma (ks) is a clinically and epidemiologically distinct human immunodeficiency virus negative form of ks occurring in africa. kaposi's sarcoma is now the most frequently reported cancer in some areas of africa. | 1996 | 8546554 |
| kaposi's sarcoma on a lymphedematous arm after mastectomy. | two patients with kaposi's sarcoma developing in an area of lymphedematous arm postmastectomy are reported. the kaposi's sarcoma occurred after latent periods of 26 and 7 years following radical and modified-radical mastectomy, respectively, in the edematous tissue of the ipsilateral arm. the cutaneous nodules were purple in color and ranged in size from a few millimeters to > 1 cm in diameter. the results of routine laboratory tests were all within normal limits. human immunodeficiency virus (h ... | 1996 | 8554044 |
| marital status in relation to kaposi's sarcoma, non-hodgkin's lymphoma, and anal cancer in the pre-aids era. | persons with human immunodeficiency virus/aids are at high risk of kaposi's sarcoma (ks), non-hodgkin lymphoma (nhl), and possibly anal cancers. to examine whether this risk preceded the aids epidemic, we used pre-aids era data from the surveillance, epidemiology, and end results program (excluding connecticut) from 1973 to 1976, and the connecticut tumor registry from 1940 to 1976. we compared risk of being single (a surrogate to identify men who might be homosexual) to those ever married, usin ... | 1996 | 8556400 |
| body-cavity-based lymphoma in an hiv-seronegative patient without kaposi's sarcoma-associated herpesvirus-like dna sequences. | 1996 | 8532016 | |
| frequent presence of a novel herpesvirus genome in lesions of human immunodeficiency virus-negative kaposi's sarcoma. | while kaposi's sarcoma (ks) is extremely common in homosexual men infected with human immunodeficiency virus (hiv), it is also found in several clinical settings in which hiv infection is absent. recently, sequences from the genome of a novel member of the herpesvirus family have been identified within ks biopsies in the aids-associated form of the disease. the presence of these sequences was sought in 6 cases of hiv-negative ks, including 4 cases of endemic ks from africa, and was found in 5 of ... | 1996 | 8537669 |
| childhood cancers in a referral hospital in kenya: a review. | following the outbreak of human immune deficiency virus (hiv) infection in the early 1980's, there has been an increase in reported cases of kaposi's sarcoma, among other childhood malignancies, from the east and central african region. to assess the status of childhood cancers at kenyatta national hospital during the aids epidemic period and to compare the findings with those obtained before the outbreak, relevant data were extracted from ward admission registers for all children admitted in th ... | 1996 | 8997844 |
| detection of hhv-8 in sjögren's syndrome. | 1996 | 9003115 | |
| [castleman's disease]. | castleman's disease, also called angiofollicular lymph node hyperplasia was first described as a distinct entity by castleman et al in 1956. two forms are now described a localized and a multicentric. the clinical and biological signs are varied and heterogeneous, and the diagnostic is made on the histologic examination. this atypical lymphoproliferative disorder is of unknown origin, but interleukin 6 play a central part in this disease. despite the benignity of this "prelymphoma state", an agg ... | 1996 | 9008748 |
| ophthalmic complications of hiv/aids. | as a result of improved treatment and patient survival, ophthalmic complications are now being seen with increasing frequency in aids, occurring in up to 75% of patients during the course of the disease. the eye may be involved by an aids-related microvasculopathy, which gives rise to cotton wool spots, and by opportunistic infections caused by a wide range of organisms, including cytomegalovirus, herpes simplex virus, varicella zoster, toxoplasma gondii, mycobacterium avium-intracellulare, trep ... | 1996 | 9015465 |
| childhood infections with human herpesviruses types 6, 7, and 8. | 1996 | 9033979 | |
| [is hvh-8 the etiologic agent for kaposi's sarcoma?]. | 1996 | 9035718 | |
| geographic and ethnic variations in the incidence of childhood cancer. | the total incidence of childhood cancer varies rather little between different regions of the world, with cumulative risk to age 15 nearly always in the range 1.0-2.5 per thousand. acute lymphoblastic leukaemia, especially in early childhood, is most common in populations of high socio-economic status and is the most frequent childhood cancer in all industrialised countries. the risk of burkitt's lymphoma is highest in tropical africa and papua new guinea; it is strongly associated with epstein- ... | 1996 | 9039726 |
| herpes virus-like sequences are specifically found in kaposi sarcoma lesions. | to detect the prevalence of herpes virus-like dna sequences in aids associated kaposi sarcoma (kshv) lesions and normal tissue. | 1996 | 8655706 |
| seroconversion to antibodies against kaposi's sarcoma-associated herpesvirus-related latent nuclear antigens before the development of kaposi's sarcoma. | if kaposi's sarcoma-associated herpesvirus (kshv) is the cause of kaposi's sarcoma, serologic evidence of infection should be present in patients before the disease develops. | 1996 | 8657239 |
| aids-related conditions: study of a representative sample of 1203 patients deceased in 1992 in france. | little representative information exists on the frequency of human immunodeficiency virus (hiv)-related diseases among the overall aids population. the objective of this research is to assess the nature, frequency and characteristics of these diseases among aids patients during their last year of life and to analyse these frequencies according to the mode of transmission and other socio-demographic and medical characteristics. | 1996 | 8666489 |
| human herpesvirus 8 and interstitial pneumonitis in an hiv-negative patient. | 1996 | 8668220 | |
| localization of human herpes-like virus type 8 in vascular endothelial cells and perivascular spindle-shaped cells of kaposi's sarcoma lesions by in situ hybridization. | kaposi's sarcoma (ks) is a neoplasm that develops as multifocal lesions characterized by a histological picture that includes irregularly shaped vascular spaces surrounded by perivascular and interstitial spindle-shaped cells, extravasated erythrocytes, and an inflammatory mononuclear cell infiltrate. recently, the dna sequences of a novel human gamma-herpesvirus-like (hhv-8) agent have been detected by polymerase chain reaction in ks associated with acquired immune deficiency syndrome (aids-ks) ... | 1996 | 8669460 |
| expression and cytokine regulation of glucocorticoid receptors in kaposi's sarcoma. | development of kaposi's sarcoma (ks) after glucocorticoid therapy has been observed in a variety of clinical states including human immunodeficiency virus-1 infection and recent in vitro studies provided evidence for a direct stimulation effect of glucocorticoid hormones on ks cell proliferation. the importance of glucocorticoids in ks pathogenesis is further highlighted by the finding that glucocorticoids synergize with cytokines to promote acquired immune deficiency syndrome (aids)-associated ... | 1996 | 8669484 |
| human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus) dna in kaposi's sarcoma lesions, aids kaposi's sarcoma cell lines, endothelial kaposi's sarcoma simulators, and the skin of immunosuppressed patients. | we used the polymerase chain reaction on 63 tissue specimens of histologically staged classic kaposi's sarcoma (ks) from 40 patients, 14 specimens from 14 acquired immune deficiency syndrome (aids)-ks cases (all from the same geographic area over a 10-year period), and peripheral blood mononuclear cells from 1 of the non-aids ks patients to amplify a specific 210-bp genomic sequence of the newly discovered ks-associated herpesvirus (kshv). also tested were 86 benign and malignant endothelial les ... | 1996 | 8669485 |
| transcription of human herpesvirus-like agent (hhv-8) in kaposi's sarcoma. | recently, dna sequences of what appear to be a unique human herpesvirus-like agent (hhv-8) have been detected in different types of kaposi's sarcoma (ks) tumors (chang, y., e.c. cesarman, m.s. pessin, f. lee, j.c. culpepper, d.m. knowles, and p.s. moore. 1994. science (wash. dc). 266:1865-1869). to further elucidate the possibility that hhv-8 plays a role in the pathogenesis of ks, the expression of hhv-8 rna was examined in fresh ks tissue specimens which were found to harbor hhv-8 dna by polym ... | 1996 | 8675691 |
| [a case of aids with bronchial tuberculosis]. | a case is 48 years-old japanese man who had a history of frequent sexual contact with prostitutes in thailand and the philippines. he presented with chief complaint of chest discomfort in april 1995. his chest x-ray film showed right mediastinal lymph node swelling in other hospital and the sputum smear was strongly positive for acid fast bacilli. in may 1995, he was admitted to our hospital and serological tests for hiv were positive both by eia and western blot methods. the cd4 lymphocyte coun ... | 1996 | 8676592 |
| establishment of aids-related lymphoma cell lines from lymphomatous effusions. | aids-related non-hodgkin lymphomas (aids-nhl) are most frequently derived from b cells and include small non-cleaved cell lymphoma (snccl) and diffuse large cell lymphoma (dlcl) and less frequently anaplastic large cell lymphoma (alcl) or body cavity-based lymphoma (bcbl). aids-nhl cell lines have proved useful to study aids-nhl pathogenesis. in this report, we describe the establishment and molecular characterization of two novel aids-nhl cell lines (hbl-4 and hbl-6) derived from lymphomatous e ... | 1996 | 8684008 |
| cyclin encoded by ks herpesvirus. | 1996 | 8684480 | |
| disseminated epidemic kaposi's sarcoma treated with radiation and chemotherapy. | when a 40-year-old patient with end-stage acquired immunodeficiency syndrome (aids) had bloating and abdominal pain, a large epidemic kaposi's sarcoma (eks) lesion was found obstructing the pylorus. treatment consisted of single-agent chemotherapy for the disseminated lesions and external beam irradiation to the obstructing lesion. within days of radiation therapy, symptoms began to resolve, and by completion of therapy, the patient was virtually asymptomatic. although eks is common in homosexua ... | 1996 | 8685761 |
| kaposi's sarcoma-associated herpesvirus in non-aids related lymphomas occurring in body cavities. | dna sequences belonging to the recently discovered kaposi's sarcoma-associated herpesvirus (kshv), now provisionally designated human herpesvirus 8, have been previously identified in an uncommonly occurring subset of aids-related lymphomas, referred to as body-cavity-based lymphomas (bcbls), which present as lymphomatous effusions. pyothorax-associated lymphomas (pals) are non-hodgkin's lymphomas that arise in the pleural cavity after long-standing pleural inflammation resulting from therapeuti ... | 1996 | 8686762 |
| the kaposi sarcoma-associated herpesvirus (kshv) is present as an intact latent genome in ks tissue but replicates in the peripheral blood mononuclear cells of ks patients. | short dna sequences have been identified, originally in association with kaposi's sarcoma (ks) biopsies, that are highly homologous to oncogenic, lymphotropic herpesviruses. recently a virus, kaposi sarcoma associated herpesvirus (kshv) or human herpesvirus-8 (hhv-8), bearing these sequences has been identified in a cell line derived from a body cavity-based lymphoma. in this report, we show that the same sequences are present in ks biopsies as dna molecules of a form and size characteristic of ... | 1996 | 8691144 |
| restricted expression of kaposi sarcoma-associated herpesvirus (human herpesvirus 8) genes in kaposi sarcoma. | kaposi sarcoma (ks) is the leading neoplasm of hiv-infected patients and is also found in several hiv-negative populations. recently, dna sequences from a novel herpesvirus, termed ks-associated herpesvirus (kshv), or human herpesvirus 8 (hhv-8) have been identified within ks tissue from both hiv-positive and hiv-negative cases; infection with this agent has been proposed as a possible factor in the etiology or pathogenesis of the tumor. here we have examined the pattern of kshv/hhv-8 gene expre ... | 1996 | 8692871 |
| primary effusion lymphoma: a distinct clinicopathologic entity associated with the kaposi's sarcoma-associated herpes virus. | we recently discovered the kaposi's sarcoma-associated herpes virus (kshv/hhv-8) in an uncommon and unusual subset of aids-related lymphomas that grow mainly in the body cavities as lymphomatous effusions without an identifiable contiguous tumor mass. the consistent presence of kshv and certain other distinctive features of these body cavity-based lymphomas suggest that they represent a distinct entity. we tested this hypothesis by investigating 19 malignant lymphomatous effusions occurring in t ... | 1996 | 8695812 |
| detection of human herpesvirus 8 dna sequences before the appearance of kaposi's sarcoma in human immunodeficiency virus (hiv)-positive subjects with a known date of hiv seroconversion. | the presence of human herpesvirus 8 (hhv-8) dna sequences was sought by polymerase chain reaction (pcr) in peripheral blood mononuclear cells of 4 groups: 6 human immunodeficiency virus (hiv)-infected persons with well-defined dates of seroconversion, during the period between the diagnosis of hiv infection and the appearance of kaposi's sarcoma (ks); 45 hiv-positive persons with no symptoms of hiv infection; 11 aids patients with ks; and 14 aids patients without ks. hhv-8 dna pcr was positive i ... | 1996 | 8699056 |
| kaposi's sarcoma (ks)-associated herpesvirus-like dna sequences in peripheral blood mononuclear cells: association with ks and persistence in patients receiving anti-herpesvirus drugs. | herpesvirus-like dna sequences (kshv/hhv-8) have recently been described in aids-associated kaposi's sarcoma (ks) lesions. many questions remain regarding the role of this virus in ks and the therapeutic implications of this finding. in the current study, kshv/hhv-8 dna was detected in peripheral blood mononuclear cells (pbmcs) from human immunodeficiency virus (hiv)-infected patients with ks (34/98) more often than in hiv-infected individuals without ks (12/64, p = .03). the detection of kshv/h ... | 1996 | 8704186 |
| the seroepidemiology of human herpesvirus 8 (kaposi's sarcoma-associated herpesvirus): distribution of infection in ks risk groups and evidence for sexual transmission. | striking differences in kaposi's sarcoma (ks) risk for aids patients who acquire hiv via homosexual activity and those whose hiv infections derive from blood product exposure suggest the presence of a sexually transmitted agent other than hiv in the development of ks. using an immunofluorescence assay, we examined serum samples from 913 patients for the presence of antibody specific for infection by human herpesvirus 8 (hhv8), an agent whose genome is regularly found in ks tissue. the distributi ... | 1996 | 8705863 |
| kshv antibodies among americans, italians and ugandans with and without kaposi's sarcoma. | a major controversy regarding kaposi's sarcoma-associated herpesvirus (kshv or hhv8) is whether or not it is a ubiquitous infection of humans. immunoassays based on kshv- and epstein-barr virus (ebv)-coinfected cell lines show that most us aids-ks patients have specific antibodies to kshv-related antigens. we have developed a sensitive indirect immunofluorescence assay (ifa) based on an ebv-negative, kshv-infected cell line, bcp-1. when we used this ifa assay, kshv-related antibodies were found ... | 1996 | 8705864 |
| detection of hhv-8/kshv dna sequences in aids-associated extranodal lymphoid malignancies. | herpesvirus-like dna sequences have been identified in a high proportion of both aids-associated and classical kaposi's sarcoma, and in a small percentage of aids-associated malignant lymphomas. to determine the extent of involvement of this new agent designated hhv-8 (human herpesvirus type 8) or kshv (kaposi's sarcoma-associated herpesvirus) in human malignant lymphomas, we analyzed 24 aids-associated lymphoid malignancies and 100 non-aids-associated lymphomas by pcr and southern blot analysis ... | 1996 | 8709643 |
| human herpesvirus-8 in aids-related and unrelated lymphomas. | 1996 | 8724048 | |
| hiv-associated lesions. | oral lesions are common in hiv infection and may be the first sign of aids. this article reviews the oral fungal and viral infections commonly detected in hiv-infected patients, particularly candidiasis, deep fungal infections, herpes simplex virus infections, cytomegalovirus infections, and oral hairy leukoplakia. the neoplasms associated with aids such as oral kaposi's sarcoma and lymphoma are related periodontal diseases. each disorder is discussed by clinical appearance, diagnosis, and manag ... | 1996 | 8725587 |
| familial kaposi's sarcoma. | familial cases of kaposi's sarcoma are exceedingly rare. we identified an 85-year-old man with kaposi's sarcoma. multiple lesions were present on the feet. previously, the man's 84-year-old sister presented with similar lesions on the lower extremity. both siblings were lifelong residents of the united states and were of english/german descent. neither had risk factors for infection with human immunodeficiency virus (hiv). on histologic examination, lesions in both patients demonstrated vascular ... | 1996 | 8727769 |
| review of external ocular disease associated with aids and hiv infection. | external ocular disease associated with human immunodeficiency virus (hiv) infection can often be overlooked by the eye care practitioner. different types of external ocular disease can be an indication of the patient's overall immune status as well as the stage of hiv infection. the external ocular sequelae of hiv infection can be of visual consequence for the patient. eye care practitioners need to become familiar with these conditions. the diagnosis and management of the following ocular cond ... | 1996 | 8728488 |
| cavitary pulmonary lesions in patients infected with human immunodeficiency virus. | the differential diagnosis of cavitary pulmonary lesions in individuals infected with human immunodeficiency virus (hiv) is broad, especially in patients with advanced disease. in patients with pneumocystis carinii pneumonia, cavitation is an uncommon manifestation of a common disease. it is unusual in patients with pulmonary cryptococcosis, coccidioidomycosis, and histoplasmosis but occurs frequently in patients with invasive pulmonary aspergillosis. in patients with pulmonary tuberculosis, cav ... | 1996 | 8729207 |
| acute myelocytic leukaemia associated with kaposi's sarcoma in a patient without serum antibodies to human immunodeficiency virus type 1. | we report a 35-year-old man with acute myelocytic leukaemia and kaposi's sarcoma, whose serum was non-reactive for antibodies to human immunodeficiency virus type-1 by enzyme-linked immunosorbent assay, western blot and immunofluorescence. complete remission of both the acute leukaemia and the kaposi's sarcoma followed treatment with mitoxantrone and cytosine arabinoside. we speculate that the rapid regression of the lesions of kaposi's sarcoma might be related to mitoxantrone and to the return ... | 1996 | 8731687 |
| restricted tissue distribution of extralesional kaposi's sarcoma-associated herpesvirus-like dna sequences in aids patients with kaposi's sarcoma. | specific herpesvirus-like dna sequences have been found in kaposi's sarcoma (ks) lesions of aids patients, suggesting that a novel gamma herpesvirus, homologous to epstein-barr virus and herpesvirus saimiri, could be implicated in the pathogenesis of ks. to better understand the role of this putative etiological agent, named kaposi's sarcoma-associated herpesvirus (kshv) or human herpesvirus 8 (hhv-8), we investigated by the polymerase chain reaction (pcr) the presence of viral dna sequences in ... | 1996 | 8744575 |
| the lung in hiv infection: can pulmonary function testing help? | simple lung function tests have been used to evaluate respiratory symptoms in human immunodeficiency virus (hiv) infected individuals. abnormalities of simple lung function tests, in particular decreases in the transfer factor of the lung for carbon monoxide (tl,co) have been described in patients with acquired immune deficiency syndrome (aids) who have respiratory disease. early studies showed marked reductions in tl,co in patients with pneumocystis pneumonia but other forms of pulmonary infect ... | 1996 | 8766197 |
| the new lymphotropic herpesviruses (hhv-6, hhv-7, hhv-8) and hepatitis c virus (hcv) in human lymphoproliferative diseases: an overview. | considerable evidence has been accumulating in favor of a possible involvement of viral agents in the pathogenesis of human lymphomas. the most recent proposal for a lymphoma classification, the revised european-american classification, emphasized for the first time the pathogenetic importance of two viruses, namely epstein-barr virus (ebv) and human t lymphotropic virus i (htlv-i) in the development of certain lymphoid neoplasias. however, in the last ten years new viral agents possibly related ... | 1996 | 8767534 |
| changes in body composition of human immunodeficiency virus-infected males receiving insulin-like growth factor i and growth hormone. | weight loss is a common, persistent characteristic of long term human immunodeficiency virus (hiv-1) infection; its full etiology remains unknown. because treatment with gh has induced nitrogen retention in various catabolic conditions, we designed this study to determine whether a moderate dose of insulin-like growth factor i (igf-i) combined with a low gh dose could impede the catabolic response seen in hiv-1 infection. a double blind, placebo-controlled study design was used. subjects in the ... | 1996 | 8768870 |
| hiv infection and neoplasia. | hiv infection predisposes to several neoplastic conditions, especially non-hodgkin lymphoma (nhl) and kaposi's sarcoma (ks), and also intraepithelial cervical neoplasia (cin) and anal neoplasia (ain) (but not cervical or anal invasive cancer) and possibly seminoma. for neoplasias associated with oncogenic human viruses (ie, some nhl, cin, ain, and probably ks) the role of hiv is most probably linked to its immunosuppressive effect and interference with immune-mediated tumour surveillance. hiv-1, ... | 1996 | 8774574 |
| kaposi's sarcoma. an update. | kaposi's sarcoma (ks) had been an uncommon entity prior to the outbreak of the aids epidemic but is now the most common neoplasm occurring in patient's with aids. ks occurs in four distinct subsets, each of which the dermatologist is well suited to diagnose and manage. significant advances have been made recently related to the etiology of ks and new options for treatment. | 1996 | 8599740 |
| kaposi's sarcoma-associated herpesvirus dna sequences in prostate tissue and human semen. | sequences of novel herpesvirus, kaposi's sarcoma-associated herpesvirus (kshv), have been indentified in kaposi's sarcoma tissue, but it is not known whether the virus is transmitted by sexual contact. | 1996 | 8602183 |
| detection of kaposi's sarcoma-associated herpesvirus-like dna sequence in vascular lesions. a reliable diagnostic marker for kaposi's sarcoma. | a new herpesvirus-like dna sequence (kshv) has been recently identified in kaposi's sarcoma (ks) from patients with aids and non-aids patients. to verify the specificity of the association of this new viral dna with ks, a total of 155 cases of benign and malignant vascular neoplasms sharing similar histogenesis of endothelial derivation were analyzed for the presence of this kshv sequence using the published 330-233 primers by polymerase chain reaction (pcr). the results revealed that all 17 cas ... | 1996 | 8602618 |
| intralesional vinblastine for treating aids-associated kaposi's sarcoma of the oropharynx and larynx. | kaposi's sarcoma (ks), the most frequent malignant neoplasm associated with acquired immunodeficiency syndrome, often involves the oropharynx and larynx. this study evaluated the efficacy of intralesional vinblastine sulfate injection in oropharyngeal and laryngeal ks. twenty-four human immunodeficiency virus-positive patients with a total of 26 ks lesions were treated with injections of 0.1- or 0.2-mg/ml vinblastine sulfate solution. subsequent injections were administered at 4- to 5-week inter ... | 1996 | 8604887 |
| acute inhalation exposure to isobutyl nitrite causes nonspecific blood cell destruction. | abuse of nitrite inhalants is widespread among male homosexuals and has been epidemiologically correlated with seropositivity to human immunodeficiency virus (hiv) and to kaposi's sarcoma. these drugs may act as cofactors in aids if they compromise the ability to resist infection or tumor growth. we have previously reported that 14 daily 45-minute exposure to 900 ppm isobutyl nitrite in an inhalation chamber did compromise the immunocompetence of mice. we now report that a single 45-minute expos ... | 1996 | 8605963 |
| primary body cavity-based aids-related lymphomas. | five patients with advanced aids developed a unique type of high grade primary body cavity-based non-hodgkin's lymphoma (nhl). the lymphomas were exclusively in serous effusions with no detectable mass disease in the body cavities and no lymphadenopathy or organomegaly. all of the lymphomas exhibited virtually identical morphology, which could not be precisely classified, but appeared to bridge features of large cell immunoblastic and anaplastic large cell lymphomas. immunophenotypically the lym ... | 1996 | 8607449 |
| long-term follow-up of non-hiv kaposi's sarcoma treated with low-dose recombinant interferon alfa-2b. | we reviewed the follow-up of 16 patients with kaposi's sarcoma not related to human immunodeficiency virus (13 with classic kaposi's sarcoma and three with endemic kaposi's sarcoma; median age, 58 years) treated by low-dose recombinant interferon alfa-2b (5 million u three times weekly for at least 6 months). | 1996 | 8607632 |
| treatment of kaposi's sarcoma. | the classic form of kaposi's sarcoma (ks) is a rare multifocal neoplasm, as described by kaposi in 1872. one hundred nine years after kaposi's first description of the disease, the interest in all aspects of this disease escalated because of the emergence of human immunodeficiency virus (hiv), which is frequently accompanied by ks. this prompted zealous research, as reflected by numerous reports. despite recent important discoveries, we are still far from understanding the pathogenesis of the di ... | 1996 | 8607639 |