Publications

assessment of preschoolers' positive empathy: concurrent and longitudinal relations with positive emotion, social competence, and sympathy.	the purpose of this study was to examine a new measure of children's dispositional positive empathy (i.e., reactions to others' positive emotions) and its concurrent and longitudinal relations with positive emotion, social competence, and empathy/sympathy with negative emotions. at time 1, 192 3.5-year-olds (88 girls) participated; at time 2, 1 year later, 168 4.5-year-olds (79 girls) participated. children's positive empathy was reported by mothers and observed in the laboratory at time 2. addi ...	20011674
delayed presentation of lateral femoral circumflex artery injury post cannulated hip screw surgery--a case report.	an elderly patient underwent cannulated hip screw surgery for a subcapital neck of femur fracture. nine days post surgery, she was noted to have collapsed with a falling haemoglobin level. computed tomography revealed a large haematoma to the thigh. further angiography showed active bleeding from one of the branches of the lateral femoral circumflex artery (lfca), which we postulate was caused by the sharp tip of a version guidewire used during fracture fixation surgery. iatrogenic injury during ...	19416578
regimented and lifestyle restraint in binge eating disorder.	this study tested the psychometric properties of two commonly used measures of dietary restraint, the three factor eating questionnaire and the eating disorder examination questionnaire.	19107829
anti-inflammatory effects of tumour necrosis factor (tnf)-alpha are mediated via tnf-r2 (p75) in tolerogenic transforming growth factor-beta-treated antigen-presenting cells.	exposure of macrophages to transforming growth factor (tgf)-beta is known to alter their functional phenotype such that antigen presentation by these cells leads to tolerance rather than an inflammatory immune response. typically, eye-derived antigen-presenting cells (apcs) exposed to tgf-beta in the local environment are known to induce a form of peripheral tolerance and protect the eye from inflammatory immune effector-mediated damage. in response to tgf-beta, apcs increase their expression of ...	18795974
empirical evidence for "syndrome z": a hierarchical 5-factor model of the metabolic syndrome incorporating sleep disturbance measures.	sleep disturbances have been associated with individual components of the metabolic syndrome ("syndrome x"), and, although the concept has been proposed, it is not known whether sleep disturbances actually cluster with features of the metabolic syndrome to produce a unifying trait, "syndrome z". therefore, we evaluated a second-order factor model, whereby syndrome z was described by 5 first-order factors--insulin resistance, obesity, hypertension, dyslipidemia, and sleep disturbance--with the sl ...	19480228
cardiovascular disease risk factors in youth with type 1 and type 2 diabetes: implications of a factor analysis of clustering.	the extent to which cardiovascular disease (cvd) risk factors cluster in youth with a diagnosis of type 1 (t1dm) or type 2 diabetes mellitus (t2dm) is unclear. therefore, we aimed to evaluate potential clustering of traditional cvd risk factors that may reflect an unmeasured but unifying single pathology that may explain the phenomenon of the metabolic syndrome in these youths.	18847385
dysfunctional high-density lipoprotein.	to address the progress of the investigation on dysfunctional high-density lipoprotein (hdl).	19306527
mediating pathways explaining psychosocial functioning and revictimization as sequelae of parental violence among adolescent mothers.	adolescent mothers are at high risk for negative life events, such as previous childhood physical abuse, impaired psychosocial functioning, and young adulthood revictimization. however, little is known about the potential pathways in these events; hence, little is known about opportunities for intervention. this study used structural equation modeling to investigate mediators of the effects of parental child abuse on later psychosocial functioning and revictimization (in the form of intimate par ...	19485635
factor structure and invariance of the quality of life in alzheimer's disease (qol-ad) scale.	the factor structure and factorial invariance of the quality of life in alzheimer's disease (qol-ad) scale was investigated in a sample of 653 nondemented, community-dwelling older adults, ages 57 to 95 years (m = 71.62, sd = 8.86), from the seattle longitudinal study. the total sample was split into two random halves to explore and confirm the structure of the qol-ad. confirmatory factor analyses indicated better fit for a three-factor solution than one- or two-factor solutions. weak factorial ...	19280450
more stories on th17 cells.	for more than two decades, immunologists have been using the so-called th1/th2 paradigm to explain most of the phenomena related to adaptive immunity. the th1/th2 paradigm implied the existence of two different, mutually regulated, cd4(+) t helper subsets: th1 cells, driving cell-mediated immune responses involved in tissue damage and fighting infection against intracellular parasites; and th2 cells that mediate ige production and are particularly involved in eosinophilic inflammation, allergy a ...	19255592
rationale for peptide and dna based epitope vaccines for alzheimer's disease immunotherapy.	amyloid-beta (abeta) immunotherapy has received considerable attention as a promising approach for reducing the level of abeta in the cns of alzheimer's disease patients. however, the first phase ii clinical trial, for the immune therapy an1792, was halted when a subset of those immunized with abeta(42) developed adverse events in the central nervous system. in addition, data from the trial indicated that there was a low percentage of responders and generally low to moderate titers in the patien ...	19355933
approaches in type 1 diabetes research: a status report.	type 1 diabetes is a multifactorial disease with an early age of onset, in which the insulin producing beta cell of the pancreas are destroyed because of autoimmunity. it is the second most common chronic disease in children and account for 5% to 10% of all diagnosed cases of diabetes. india is having an incidence of 10.6 cases/year/100,000, and recent studies indicate that the prevalence of type 1 diabetes in india is increasing. however in view of poor health care network, there is no monitori ...	20142874
mothers' intentions to teach adolescent daughters about breast cancer risk reduction activities: the influence of self-efficacy, response efficacy, & personal responsibility.	the current study examined whether self-efficacy (se), response efficacy (re), and personal responsibility (pr) affect mothers' intentions (n=139) to teach their adolescent and pre-adolescent daughters about breast cancer risk reduction measures such as maintaining a healthy diet, exercising on a regular basis, and avoiding chemical exposures. results showed that both se and re were related to mothers' intentions to teach their daughters how to maintain a healthy diet, engage in regular exercise ...	19890468
informant-based dementia screening in a population-based sample of african americans.	an informant-based screening tool for dementia may be useful in population-based studies of minority populations.	19484913
validating the multidimensional measure of cultural identity scales for latinos among latina mothers and daughters.	the psychometric properties of the multidimensional measure of cultural identity scales for latinos (mmcisl; félix-ortiz, newcomb, & myers, 1994) have never been examined in an adult latina sample representing various levels of nativity and nationality. the rationale for the study was to confirm the factor structure and psychometric properties of the mmcisl with a predominantly immigrant sample of latina mothers and daughters (n = 316). adequate reliability estimates were found for 6 of the orig ...	19364206
patient health questionnaire-9 in spinal cord injury: an examination of factor structure as related to gender.	despite the attention depression after spinal cord injury (sci) has received, research and clinical practice have been hampered by inadequate emphasis on reliable and valid measurement. assessment of symptoms in persons with sci is challenged by the presence of "trans-diagnostic" symptoms and unexamined effects of gender. the objective of this study was to examine the factor structure of the patient health questionnaire-9 (phq-9; the 9-item depression scale of the patient health questionnaire) a ...	19569462
metformin attenuated the autoimmune disease of the central nervous system in animal models of multiple sclerosis.	experimental autoimmune encephalomyelitis (eae) is a t cell-mediated autoimmune disease of the cns. metformin is the most widely used drug for diabetes and mediates its action via activating amp-activated protein kinase (ampk). we provide evidence that metformin attenuates the induction of eae by restricting the infiltration of mononuclear cells into the cns, down-regulating the expression of proinflammatory cytokines (ifn-gamma, tnf-alpha, il-6, il-17, and inducible no synthase (inos)), cell ad ...	19494326
construct validity: advances in theory and methodology.	measures of psychological constructs are validated by testing whether they relate to measures of other constructs as specified by theory. each test of relations between measures reflects on the validity of both the measures and the theory driving the test. construct validation concerns the simultaneous process of measure and theory validation. in this article, we review the recent history of validation efforts in clinical psychological science that has led to this perspective, and we review the ...	19086835
sex differences in gabaa signaling in the periaqueductal gray induced by persistent inflammation.	the ventrolateral periaqueductal gray (vlpag) is a key structure in the descending pain modulatory circuit. activation of the circuit occurs via disinhibition of gabaergic inputs onto vlpag output neurons. in these studies, we tested the hypothesis that gabaergic inhibition is increased during persistent inflammation, dampening activation of the descending circuit from the vlpag. our results indicate that persistent inflammation induced by complete freund's adjuvant (cfa) modulates gaba signalin ...	26843648
dysautonomia rating scales in parkinson's disease: sialorrhea, dysphagia, and constipation--critique and recommendations by movement disorders task force on rating scales for parkinson's disease.	upper and lower gastrointestinal dysautonomia symptoms (gids)--sialorrhea, dysphagia, and constipation are common in parkinson's disease (pd) and often socially as well as physically disabling for patients. available invasive quantitative measures for assessing these symptoms and their response to therapy are time-consuming, require specialized equipment, can cause patient discomfort and present patients with risk. the movement disorders society commissioned a task force to assess available clin ...	19205066
gestation and breastfeeding in schistosomotic mothers differently modulate the immune response of adult offspring to postnatal schistosoma mansoni infection.	schistosoma mansoni antigens in the early life alter homologous and heterologous immunity during postnatal infections. we evaluate the immunity to parasite antigens and ovalbumin (oa) in adult mice born/suckled by schistosomotic mothers. newborns were divided into: born (bim), suckled (sim) or born/suckled (bsim) in schistosomotic mothers, and animals from noninfected mothers (control). when adults, the mice were infected and compared the hepatic granuloma size and cellularity. some animals were ...	26872339
patient-reported factors associated with reengagement among hiv-infected patients disengaged from care in east africa.	engagement in care is key to successful hiv treatment in resource-limited settings; yet little is known about the magnitude and determinants of reengagement among patients out of care. we assessed patient-reported reasons for not returning to clinic, identified latent variables underlying these reasons, and examined their influence on subsequent care reengagement.	26765940
rest pain and movement-evoked pain as unique constructs in hip and knee replacements.	there is limited information about the extent to which the association between preoperative and chronic postoperative pain is mediated via pain-on-movement or pain-at-rest. we explored these associations in patients undergoing total hip replacement (thr) and total knee replacement (tkr).	26212349
utility of the 3di short version for the diagnostic assessment of autism spectrum disorder and compatibility with dsm-5.	the developmental diagnostic dimensional interview-short version (3di-sv) provides a brief standardized parental interview for diagnosing autism spectrum disorder (asd). this study explored its validity, and compatibility with dsm-5 asd. 3di-sv classifications showed good sensitivity but low specificity when compared to ados-2-confirmed clinical diagnosis. confirmatory factor analyses found a better fit against a dsm-5 model than a dsm-iv-tr model of asd. exploration of the content validity of t ...	26825661
decreased signal transducers and activators of transcription (stat) protein expression in lymphatic organs during eae development in mice.	experimental autoimmune encephalomyelitis (eae) is mediated by myelin-specific cd4+ t cells secreting th1 and/or th17 cytokines. signal transducer and activator of transcription (stat) family proteins have essential roles in transmitting th1 and/or th17 cytokine-mediated signals. however, most studies demonstrating the importance of the stat signaling system in eae have focused on distinct members of this family, often looking at their role specifically in the central nervous system, or in vitro ...	25346854
human melanoma immunotherapy using tumor antigen-specific t cells generated in humanized mice.	a major factor hindering the exploration of adoptive immunotherapy in preclinical settings is the limited availability of tumor-reactive human t cells. here we developed a humanized mouse model that permits large-scale production of human t cells expressing the engineered melanoma antigen mart-1-specific tcr. humanized mice, made by transplantation of human fetal thymic tissue and cd34+ cells virally-transduced with hla class i-restricted melanoma antigen (mart-1)-specific tcr gene, showed effic ...	26824989
a novel intracellular antibody against the e6 oncoprotein impairs growth of human papillomavirus 16-positive tumor cells in mouse models.	single-chain variable fragments (scfvs) expressed as "intracellular antibodies" (intrabodies) can target intracellular antigens to hamper their function efficaciously and specifically. here we use an intrabody targeting the e6 oncoprotein of human papillomavirus 16 (hpv16) to address the issue of a non-invasive therapy for hpv cancer patients.a scfv against the hpv16 e6 was selected by intracellular antibody capture technology and expressed as i7nuc in the nucleus of hpv16-positive siha, hpv-neg ...	26788990
ectonucleotidase activity and immunosuppression in astrocyte-cd4 t cell bidirectional signaling.	astrocytes play a crucial role in neuroinflammation as part of the glia limitans, which regulates infiltration of the brain parenchyma by leukocytes. the signaling pathways and molecular events, which result from the interaction of activated t cells with astrocytes are poorly defined. here we show that astrocytes promote the expression and enzymatic activity of cd39 and cd73 ectonucleotidases in recently activated cd4 cells by a contact dependent mechanism that is independent of t cell receptor ...	26784253
causal link between the cortico-rubral pathway and functional recovery through forced impaired limb use in rats with stroke.	intensive rehabilitation is believed to induce use-dependent plasticity in the injured nervous system; however, its causal relationship to functional recovery is unclear. here, we performed systematic analysis of the effects of forced use of an impaired forelimb on the recovery of rats after lesioning the internal capsule with intracerebral hemorrhage (ich). forced limb use (flu) group rats exhibited better recovery of skilled forelimb functions and their cortical motor area with forelimb repres ...	26758837
sustained suppression of hyperalgesia during latent sensitization by μ-, δ-, and κ-opioid receptors and α2a adrenergic receptors: role of constitutive activity.	many chronic pain disorders alternate between bouts of pain and periods of remission. the latent sensitization model reproduces this in rodents by showing that the apparent recovery ("remission") from inflammatory or neuropathic pain can be reversed by opioid antagonists. therefore, this remission represents an opioid receptor-mediated suppression of a sustained hyperalgesic state. to identify the receptors involved, we induced latent sensitization in mice and rats by injecting complete freund's ...	26740662
nonparalytic botulinum molecules for the control of pain.	local injections of botulinum toxins have been reported to be useful not only for the treatment of peripheral neuropathic pain and migraine but also to cause long-lasting muscle paralysis, a potentially serious side effect. recently, a botulinum a-based molecule ("bitox") has been synthesized that retains neuronal silencing capacity without triggering muscle paralysis. in this study, we examined whether bitox delivered peripherally was able to reduce or prevent the increased nociceptive sensitiv ...	26761389
overcoming enterotoxigenic escherichia coli pathogen diversity: translational molecular approaches to inform vaccine design.	enterotoxigenic escherichia coli (etec) are a genetically diverse e. coli pathovar that share in the ability to produce heat-labile toxin and/or heat-stable toxins. while these pathogens contribute substantially to the burden of diarrheal illness in developing countries, at present, there is no suitable broadly protective vaccine to prevent these common infections. most vaccine development attempts to date have followed a classical approach involving a relatively small group of antigens. the ext ...	27076141
a measure of college student persistence in the sciences (pits).	curricular changes that promote undergraduate persistence in science, technology, engineering, and mathematics (stem) disciplines are likely associated with particular student psychological outcomes, and tools are needed that effectively assess these developments. here, we describe the theoretical basis, psychometric properties, and predictive abilities of the persistence in the sciences (pits) assessment survey designed to measure these in course-based research experiences (cres). the survey is ...	27810869
introducing the postsecondary instructional practices survey (pips): a concise, interdisciplinary, and easy-to-score survey.	researchers, administrators, and policy makers need valid and reliable information about teaching practices. the postsecondary instructional practices survey (pips) is designed to measure the instructional practices of postsecondary instructors from any discipline. the pips has 24 instructional practice statements and nine demographic questions. users calculate pips scores by an intuitive proportion-based scoring convention. factor analyses from 72 departments at four institutions (n = 891) supp ...	27810868
the effect of treatment with resiniferatoxin and capsaicin on dynamic weight bearing measures and evoked pain responses in a chronic inflammatory arthritis murine model.	capsaicin (cap) and resiniferatoxin (rtx) are vanilloid receptor agonists that can normalize evoked pain scores (eps) and automated dynamic weight bearing (adwb) measures in murine acute inflammatory arthritis when given by intra-articular (ia) injection. to determine whether these vanilloid receptor agonists have benefit in complete freund's adjuvant (cfa) induced chronic inflammatory arthritis pain, we measured changes in adwb and eps in arthritic mice with and without treatment with ia cap an ...	27774522
patient experience in an era of primary care transformation: revisiting the pacic.	aims and objective: the validation study of the patient assessment of chronic illness care (pacic) questionnaire suggested a 5-factor structure determined a priori, but subsequent analyses have questioned the validity of the original factor structure. this study analyzed the factor structure of the pacic using a large and diverse patient sample, and evaluated the identified factors through the lens of recent transformational initiatives in primary care.	27746917
fatal cases of gestational trophoblastic neoplasia in a national trophoblastic disease reference center in dakar senegal.	the objectives of this study were to analyze deaths after gestational trophoblastic neoplasia and to determine the factors of treatment failure.	27622010
psychometric properties and confirmatory structure of the strengths and difficulties questionnaire in a sample of adolescents in nigeria.	though the sdq has been used in selected studies in nigeria, its theoretical structure has not been fully and appropriately investigated in the setting. the present study employs exploratory factor analysis (efa) and confirmatory factor analysis (cfa) to investigate the theoretical structure of the self-reported version of the sdq in a sample of adolescents in benue state, nigeria. a total of 1,244 adolescents from different categories of secondary schools in makurdi and vandekya local governmen ...	27478714
early caregiving stress exposure moderates the relation between respiratory sinus arrhythmia reactivity at 1 month and biobehavioral outcomes at age 3.	there is a growing scientific interest in the psychophysiological functioning of children living in low-socioeconomic status (ses) contexts, though this research is complicated by knowledge that physiology-behavior relations often operate differently in these environments among adults. importantly, such research is made more difficult because ses may be a proxy for a wide range of risk factors including poor caregiving and exposure to parental substance use. we used factor analysis to organize r ...	26681620
validity and reliability of the developmental assessment screening scale.	to develop and validate the 6-year ages and stages questionnaire (asq) for school-age children.	27453856
the emerging role of spinal dynorphin in chronic pain: a therapeutic perspective.	notable findings point to the significance of the dynorphin peptide neurotransmitter in chronic pain. spinal dynorphin neuropeptide levels are elevated during development of chronic pain and sustained during persistent chronic pain. importantly, knockout of the dynorphin gene prevents development of chronic pain in mice, but acute nociception is unaffected. intrathecal (it) administration of opioid and nonopioid dynorphin peptides initiates allodynia through a nonopioid receptor mechanism; furth ...	26738478
animal magnetism, psychiatry and subjective experience in nineteenth-century germany: friedrich krauß and his nothschrei.	friedrich krauß (1791-1868) is the author of nothschrei eines magnetisch-vergifteten [cry of distress by a victim of magnetic poisoning] (1852), which has been considered one of the most comprehensive self-narratives of madness published in the german language. in this 1018-page work krauß documents his acute fears of 'mesmerist' influence and persecution, his detainment in an antwerp asylum and his encounter with various illustrious physicians across europe. though in many ways comparable to ot ...	26651186
psychometric properties of the satisfaction with life scale (swls) in iranian infertile women.	infertility is a global public health issue and may adversely affect life satisfaction. one of the most widely instruments used to assess life satisfaction is the satisfaction with life scale (swls).	27141550
functionally expression of metalloproteinase in taenia solium metacestode and its evaluation for serodiagnosis of cysticercosis.	parasite proteases have important roles in cleavage of host proteins during the invasion of host tissues and participate in the parasite's evasion from the host's immune response. the aim of the present study was to estimate a metalloproteinase properties of taenia solium metacestode (tsmp) during host-parasite interactions, and evaluate its potential as a serodiagnostic antigen for cysticercosis.	27095967
a self-efficacy questionnaire regarding leisure time physical activity: psychometric properties among iranian male adolescents.	attention to different aspects of self-efficacy leads to actual evaluation of self-efficacy about physical activity. this study was carried out in order to design and determine psychometric characteristics of a questionnaire for evaluation of self-efficacy about leisure time physical activity (selpa) among iranian adolescent boys, with an emphasis on regulatory self-efficacy.	26985219
development of the stress of immigration survey: a field test among mexican immigrant women.	the stress of immigration survey (sois) is a screening tool used to assess immigration-related stress. the mixed methods approach included concept development, pretesting, field testing, and psychometric evaluation in a sample of 131 low-income women of mexican descent. the 21-item sois screens for stress related to language, immigrant status, work issues, yearning for family and home country, and cultural dissonance. mean scores ranged from 3.6 to 4.4 (a scale of 1-5, higher is more stress). cr ...	26605954
factor structure of cognition and functional capacity in two studies of schizophrenia and bipolar disorder: implications for genomic studies.	impairments in cognition and everyday functioning are common in schizophrenia and bipolar disorder (bpd). in this article, we present factor analyses of cognitive and functional capacity (fc) measures based on 2 studies of schizophrenia (scz) and bipolar i disorder (bpi) using similar methods. the overall goal of these analyses was to determine whether performance-based assessments should be examined individually, or aggregated on the basis of the correlational structure of the tests, as well as ...	26710094
factors determining optimal fatty acid absorption in preterm infants.	the aim of the present study was to quantify absorption coefficients of specific fatty acids in preterm infants as a function of diet, formula or breast milk (bm), and postnatal age; to identify the fatty acid structural characteristics that determine optimal fatty acid absorption.	26252920
hiv stigma in prisons and jails: results from a staff survey.	with numerous hiv service gaps in prisons and jails, there has been little research on hiv stigma attitudes among correctional staff. such attitudes may undermine hiv services for inmates at risk of or infected with hiv. this hiv stigma attitudes survey among 218 correctional staff in 32 us facilities (1) provides an overview of staff's stigma attitudes, (2) reports psychometric analyses of domains in earnshaw and chaudoir's hiv stigma framework (hsf), and (3) explores differences in stigma atti ...	26036464
experimental autoimmune encephalomyelitis in mice.	experimental autoimmune encephalitis (eae), the animal model of multiple sclerosis (ms), has provided significant insight into the mechanisms that initiate and drive autoimmunity. several central nervous system proteins and peptides have been used to induce disease, in a number of different mouse strains, to model the diverse clinical presentations of ms. in this chapter, we detail the materials and methods used to induce active and adoptive eae. we focus on disease induction in the sjl/j, c57bl ...	25005074
'wanting' and 'liking' skin picking: a validation of the skin picking reward scale.	excoriation (skin-picking) disorder (spd) is often conceptualized as a behavioral addiction in which aberrant reward processing may play an important role. the current study sought to develop a self-report instrument--the skin picking reward scale (sprs)--that measures how strongly skin picking is 'liked' (i.e., the degree of pleasurable feelings while receiving the reward) and 'wanted' (i.e., the degree of the motivation to seek the reward).	26690620
poster session imonday, december 7, 2015.		26632286
panels, mini-panels and study groupsmonday, december 7, 2015.		26632285
development of an anti-elicitin antibody-based immunohistochemical assay for diagnosis of pythiosis.	pythiosis is an emerging and life-threatening infectious disease of humans and animals living in tropical and subtropical countries and is caused by the fungus-like organism pythium insidiosum. antifungals are ineffective against this pathogen. most patients undergo surgical removal of the infected organ, and many die from advanced infections. early and accurate diagnosis leads to prompt management and promotes better prognosis for affected patients. immunohistochemical assays (ihcs) have been d ...	26719582
complicated whipple's disease and endocarditis following tumor necrosis factor inhibitors.	to test whether treatment with tumor necrosis factor inhibitors (tnfi) is associated with complications of tropheryma whipplei (t. whipplei) infection.	25548618
gitrl modulates the activities of p38 mapk and stat3 to promote th17 cell differentiation in autoimmune arthritis.	the glucocorticoid-induced tnfr family-related protein (gitr) and its ligand play a critical role in the pathogenesis of autoimmune arthritis by enhancing the th17 cell response, but their molecular mechanisms remain largely unclear. this study aims to define the role of p38 mitogen-activated protein kinases (mapk) and signal transducer and activator of transcription 3 (stat3) signaling in gitrl-induced th17 cells in autoimmune arthritis. we found that the p38 phosphorylation was enhanced by git ...	26657118
novel cxcl13 transgenic mouse: inflammation drives pathogenic effect of cxcl13 in experimental myasthenia gravis.	abnormal overexpression of cxcl13 is observed in many inflamed tissues and in particular in autoimmune diseases. myasthenia gravis (mg) is a neuromuscular disease mainly mediated by anti-acetylcholine receptor autoantibodies. thymic hyperplasia characterized by ectopic germinal centers (gcs) is a common feature in mg and is correlated with high levels of anti-achr antibodies. we previously showed that the b-cell chemoattractant, cxcl13 is overexpressed by thymic epithelial cells in mg patients. ...	26771137
animal models of bone loss in inflammatory arthritis: from cytokines in the bench to novel treatments for bone loss in the bedside-a comprehensive review.	throughout life, bone is continuously remodelled. bone is formed by osteoblasts, from mesenchymal origin, while osteoclasts induce bone resorption. this process is tightly regulated. during inflammation, several growth factors and cytokines are increased inducing osteoclast differentiation and activation, and chronic inflammation is a condition that initiates systemic bone loss. rheumatoid arthritis (ra) is a chronic inflammatory auto-immune disease that is characterised by active synovitis and ...	26634933
exacerbation of experimental autoimmune encephalomyelitis in mice deficient for dcir, an inhibitory c-type lectin receptor.	dendritic cell immunoreceptor (dcir) is a c-type lectin receptor containing a carbohydrate recognition domain in its extracellular portion and an immunoreceptor tyrosine–based inhibitory motif, which transduces negative signals into cells, in its cytoplasmic portion. previously, we showed that dcir(–/–) mice spontaneously develop autoimmune diseases such as enthesitis and sialadenitis due to excess expansion of dendritic cells (dcs), suggesting that dcir is critically important for the homeostas ...	26176030
immune tolerance induction against experimental autoimmune encephalomyelitis (eae) using a new plp-b7ap conjugate that simultaneously targets b7/cd28 costimulatory signal and tcr/mhc-ii signal.	most of the current therapies used in the treatment of multiple sclerosis (ms) are either ineffective or have adverse side effects. as such, there is a need to develop better therapies that specifically target myelin-specific aberrant immune cells involved in cns inflammation without compromising the general immune system. in the present study, we developed a new bifunctional peptide inhibitor (bpi) that is effective and specific. our bpi (plp-b7ap) is composed of an antigenic peptide from myeli ...	26140285
pathogenesis and clinical aspects of pain in patients with osteoporosis.	bone pain is one of the most frequent kinds of chronic pain, mainly in elderly patients. it causes a significant worsening of functional capacity and deterioration in the quality of life in people affected. mechanisms of pain in osteoporosis are poorly known and often extrapolated by other pathologies or other experimental model. one of principal causes would be a "hyper-remodeling" of bone, that involves osteoclasts activity and pathological modifications of bone innervation. several studies sh ...	25568647
silencing mir-146a influences b cells and ameliorates experimental autoimmune myasthenia gravis.	micrornas have been shown to be important regulators of immune homeostasis as patients with aberrant microrna expression appeared to be more susceptible to autoimmune diseases. we recently found that mir-146a was up-regulated in activated b cells in response to rat acetylcholine receptor (achr) α-subunit 97-116 peptide, and this up-regulation was significantly attenuated by antagomir-146a. our data also demonstrated that silencing mir-146a with its inhibitor antagomir-146a effectively ameliorate ...	24962817
confirming the multidimensionality of psychologically controlling parenting among chinese-american mothers: love withdrawal, guilt induction, and shaming.	despite the theoretical conceptualization of parental psychological control as a multidimensional construct, the majority of previous studies have examined psychological control as a unidimensional scale. moreover, the conceptualization of shaming and its associations with love withdrawal and guilt induction are unclear. the current study aimed to fill these gaps by evaluating the latent factor structure underlying 18 items from olsen et al. (2002) that were conceptually relevant to love withdra ...	26052168
piezo2 is the major transducer of mechanical forces for touch sensation in mice.	the sense of touch provides critical information about our physical environment by transforming mechanical energy into electrical signals. it is postulated that mechanically activated cation channels initiate touch sensation, but the identity of these molecules in mammals has been elusive. piezo2 is a rapidly adapting, mechanically activated ion channel expressed in a subset of sensory neurons of the dorsal root ganglion and in cutaneous mechanoreceptors known as merkel-cell-neurite complexes. i ...	25471886
gut microbiota elicits a protective immune response against malaria transmission.	glycosylation processes are under high natural selection pressure, presumably because these can modulate resistance to infection. here, we asked whether inactivation of the udp-galactose:β-galactoside-α1-3-galactosyltransferase (α1,3gt) gene, which ablated the expression of the galα1-3galβ1-4glcnac-r (α-gal) glycan and allowed for the production of anti-α-gal antibodies (abs) in humans, confers protection against plasmodium spp. infection, the causative agent of malaria and a major driving force ...	25480293
assessing the quality of parent-teacher relationships for students with adhd.	family involvement in education, including quality of family-school communication, has been demonstrated repeatedly to have a substantial effect on child development and success in school; however, measures of this construct are limited. the purpose this study was to examine the factor structure and concurrent validity of the quality of the parent-teacher relationship, a subscale of the parent-teacher involvement questionnaire (ptiq) in a sample of children with adhd. participants were 260 paren ...	25663718
executive function among preschool children: unitary versus distinct abilities.	working memory (wm) and inhibitory control (ic) are considered related but separable executive functions (efs) among adults and adolescents. although available evidence suggests that these constructs have not diverged especially among younger preschool children, questions remain regarding the age at which separable factors emerge. this study used confirmatory factor analysis to test a 2-factor model of ef among 289 preschool children whose ages ranged from 45 to 63 months (m = 55.74, sd = 7.56). ...	25642020
immune modulation of b. terrestris worker (a type of bumblebee), extract on cfa-induced paw edema in rats.	to develop a composition for enhancing immunity, based on alcohol extracts of the bumblebee as an active ingredient, bumblebee ethanol extracts were evaluated for their protective effect in chronic models of inflammation, adjuvant induced rat arthritis. b. terrestris worker extract (sdiex) and, b. hypocrita sapporoensis lava an pupa extract (spdybex), significantly decreased paw edema in arthritic rats, at a dose 100 mg/kg, respectively. the cytokine levels related inflammation of cox-2, spla2, ...	25584147
psychometric properties of the system for coding couples' interactions in therapy--alcohol.	few systems are available for coding in-session behaviors for couples in therapy. alcohol behavioral couple therapy (abct) is an empirically supported treatment, but little is known about its mechanisms of behavior change. in the current study, an adapted version of the motivational interviewing for significant others coding system was developed into the system for coding couples' interactions in therapy-alcohol (sccit-a), which was used to code couples' interactions and behaviors during abct. r ...	25528049
the well-being 5: development and validation of a diagnostic instrument to improve population well-being.	building upon extensive research from 2 validated well-being instruments, the objective of this research was to develop and validate a comprehensive and actionable well-being instrument that informs and facilitates improvement of well-being for individuals, communities, and nations. the goals of the measure were comprehensiveness, validity and reliability, significant relationships with health and performance outcomes, and diagnostic capability for intervention. for measure development and valid ...	24892873
the fluence effects of low-level laser therapy on inflammation, fibroblast-like synoviocytes, and synovial apoptosis in rats with adjuvant-induced arthritis.	the aim of this study was to evaluate the effect of low-level laser therapy (lllt) operating at low and high fluences on joint inflammation, fibroblast-like synoviocytes (fls), and synovial apoptosis in rats with adjuvant-induced arthritis.	25394331
targeted gas6 delivery to the cns protects axons from damage during experimental autoimmune encephalomyelitis.	growth arrest-specific protein 6 (gas6) is a soluble agonist of the tyro3, axl, mertk (tam) family of receptor tyrosine kinases identified to have anti-inflammatory, neuroprotective, and promyelinating properties. during experimental autoimmune encephalomyelitis (eae), wild-type (wt) mice demonstrate a significant induction of gas6, axl, and mertk but not pros1 or tyro3 mrna. we tested the hypothesis that intracerebroventricular delivery of gas6 directly into the cns of wt mice during myelin oli ...	25471571
modulation of immune response by ultra-violet light in hla class-ii transgenic mice.	multiple sclerosis (ms) is a chronic and debilitating disease of the central nervous system linked to both genetic and environmental factors. among the genetic factors, mhc, especially hla class-ii, is strongly associated with predisposition to ms. although in vitro studies have helped us understand some aspects of hla class-ii association with the disease, performing in vivo analysis is necessary in order to further understand this correlation. studying the role of class-ii genes in vivo is a d ...	26473171
neighborhood racial composition, racial discrimination, and depressive symptoms in african americans.	while evidence indicates that experienced racial discrimination is associated with increased depressive symptoms for african americans, there is little research investigating predictors of experienced racial discrimination. this paper examines neighborhood racial composition and sociodemographic factors as antecedents to experienced racial discrimination and resultant levels of depressive symptoms among african american adults. the sample included 505 socioeconomically-diverse african american a ...	24969707
developing a measure of traffic calming associated with elementary school students' active transport.	the objective of this study is to develop a measure of traffic calming with nationally available gis data from navteq and to validate the traffic calming index with the percentage of children reported by school administrators as walking or biking to school, using data from a nationally representative sample of elementary schools in 2006-2010. specific models, with and without correlated errors, examined associations of objective gis measures of the built environment, nationally available from na ...	25506255
the amino acids 736-761 of the mers-cov spike protein induce neutralizing antibodies: implications for the development of vaccines and antiviral agents.	based on a bioinformatics analysis of the middle east respiratory syndrome coronavvirus (mers-cov) s protein, we synthesized a panel of peptides coupled to keyhole limpet haemocyanin and used them to raise antibodies in rabbits. in addition, the recombinant receptor-binding domain (rbd) was used to raise polyclonal antibodies in mice. all of the antibodies raised by s-peptide immunisation were specific and sensitive for s protein expressed in transfected cells in the indirect immunofluorescence ...	25387086
random intercept efa of personality scales.	previous research suggests that simple structure cfas of big five personality measures fail to accurately reflect the scale's complex factorial structure, whereas efas generally perform better. another strand of research suggests that acquiescence or uniform response bias masks the scale's "true" factorial structure. random intercept efa (ri-efa) captures acquiescence as well as the complex item-factor structure typical for personality measures. it is applied to the neo-ffi and the bfi scale to ...	25484472
overview of classification systems in peripheral artery disease.	peripheral artery disease (pad), secondary to atherosclerotic disease, is currently the leading cause of morbidity and mortality in the western world. while pad is common, it is estimated that the majority of patients with pad are undiagnosed and undertreated. the challenge to the treatment of pad is to accurately diagnose the symptoms and determine treatment for each patient. the varied presentations of peripheral vascular disease have led to numerous classification schemes throughout the liter ...	25435665
iliac arteries: how registries can help improve outcomes.	there are many publications reporting excellent short and long-term results with endovascular techniques. patients included in trials are often highly selected and may not represent real world practice. registries are important to interventional radiologists for several reasons; they reflect prevailing practice and can be used to establish real world standards of care and safety profiles. this information allows individuals and centers to evaluate their outcomes compared with national norms. the ...	25435659
treating calf and pedal vessel disease: the extremes of intervention.	recent developments in catheter, balloon, and guidewire technology have increased the scope for endovascular treatments in the management of complex and challenging disease in the calf and foot. the antegrade femoral approach remains the starting point for most interventions, but there is a growing role for procedures performed from unconventional access such as the pedal arteries. this article reviews the indications for intervention, atypical access, and the choice of equipment for these extre ...	25435656
complications and great escapes: equipment and techniques.	all endovascular procedures have the potential for complications. the primary aims should always be avoidance of preventable complications and to minimize the impact of any complication. the core principles of an effective preventive strategy are: involving the interventional and clinical teams in a clear outline of the procedure and its potential adverse outcomes; ensuring an adequate inventory of required and backup equipment; the use of "time-out" to minimize wrong patient/wrong side adverse ...	25435662
access and hemostasis: femoral and popliteal approaches and closure devices-why, what, when, and how?	this article reviews the arterial access sites used in the treatment of peripheral arterial disease, including common femoral, superficial femoral, and popliteal arterial puncture. the optimal approach and techniques for arterial puncture will be described and technical tips and tricks will be discussed. an overview of the currently available vascular closure devices will also be presented. indications, contraindications, and complications will be discussed. results of the use of vascular closur ...	25435661
vascular imaging: the evolving role of the multidisciplinary team meeting in peripheral vascular disease.	this article reviews the importance of preinterventional cross-sectional imaging in the evaluation of peripheral arterial disease, as well as discussing the pros and cons of each imaging modality. the importance of a multidisciplinary team approach is emphasized.	25435657
testing negative means i'm lucky, making good choices, or immune: diverse reactions to hiv test results are associated with risk behaviors.	hiv testing may lead to behavioral changes among some individuals, but no scale has been developed to assess potential mechanisms.	24817015
observation of spontaneous expressive language (osel): a new measure for spontaneous and expressive language of children with autism spectrum disorders and other communication disorders.	a new language measure, the observation of spontaneous expressive language (osel), is intended to document spontaneous use of syntax, pragmatics, and semantics in 2-12-year-old children with autism spectrum disorder (asd) and other communication disorders with expressive language levels comparable to typical 2-5 year olds. because the purpose of the osel is to provide developmental norms for use of language, the first step involves assessment of the scale's feasibility, validity, and reliability ...	25022249
friendship intimacy, close friend drug use, and self-medication in adolescence.	the current study examined between- and within-person processes related to friendship intimacy, close-friend substance use, negative affect, and self-medication. we tested between-person hypotheses that global negative affect, friendship intimacy, and close-friend drug use predict increased substance use, and the within-person hypothesis that friendship intimacy and close-friend substance use moderate the temporal relationship between daily negative affect and subsequent substance use (i.e., sel ...	25473144
emotional and behavioral problems among impoverished kenyan youth: factor structure and sex-differences.	data on youth emotional and behavioral problems from societies in sub-saharan africa are lacking. this may be due to the fact that few youth mental health assessments have been tested for construct validity of syndrome structure across multicultural societies that include developing countries, and almost none have been tested in sub-saharan africa. the youth self-report (ysr), for example, has shown great consistency of its syndrome structure across many cultures, yet data from only one developi ...	25419046
monitoring by parents and hypothesized male-female differences in evidence from a nationally representative cohort re-sampled from age 12 to 17 years: an exploratory study using a "mutoscope" approach.	the link between adept parental monitoring (pm) and later positive behavioral and health outcomes already has motivated intervention trials, but questions remain about which specific facets and mechanisms of pm make a difference. our current research questions concern fundamental male-female differences in pm facets as manifest in a us cohort, re-sampled each year at age 12 through 17 years during an interval from 2004 to 2009. we hypothesized emergence, by mid-adolescence, of a specific male-fe ...	25429727
applying a multiple group causal indicator modeling framework to the reading comprehension skills of third, seventh, and tenth grade students.	this study demonstrates the utility of applying a causal indicator modeling framework to investigate important predictors of reading comprehension in third, seventh, and tenth grade students. the results indicated that a 4-factor multiple indicator multiple indicator cause (mimic) model of reading comprehension provided adequate fit at each grade level. this model included latent predictor constructs of decoding, verbal reasoning, nonverbal reasoning, and working memory and accounted for a large ...	25821346
impact of suppressing retinoic acid-related orphan receptor gamma t (ror)γt in ameliorating central nervous system autoimmunity.	multiple sclerosis (ms) is an immune-mediated chronic central nervous system (cns) disease affecting more than 400 000 people in the united states. myelin-reactive cd4 t cells play critical roles in the formation of acute inflammatory lesions and disease progression in ms and experimental autoimmune encephalomyelitis (eae), a well-defined mouse model for ms. current ms therapies are only partially effective, making it necessary to develop more effective therapies that specifically target pathoge ...	25142403
in vivo properties of knt-127, a novel δ opioid receptor agonist: receptor internalization, antihyperalgesia and antidepressant effects in mice.	activation of δ opioid (dop) receptors regulates pain and emotional responses, and also displays ligand-biased agonism. knt-127 (1,2,3,4,4a,5,12,12a-octahydro-2-methyl-4aβ,1β-([1,2]benzenomethano)-2,6-diazanaphthacene-12aβ,17-diol) is a novel dop receptor agonist inducing analgesia and antidepressant effects in mice. here, we have assessed knt-127 for (i) analgesia against chronic inflammatory pain; (ii) effects on depression, locomotion and dop receptor internalization; and (iii) for cross-tole ...	25048778
bifunctional peptide inhibitors suppress interleukin-6 proliferation and ameliorates murine collagen-induced arthritis.	the objective of this study is to evaluate the efficacy and potential mechanism of action of type-ii collagen bifunctional peptide inhibitor (cii-bpi) molecules in suppressing rheumatoid arthritis in the collagen-induced arthritis (cia) mouse model. cii-bpi molecules (cii-bpi-1, cii-bpi-2, and cii-bpi-3) were formed through conjugation between an antigenic peptide derived from type-ii collagen and a cell adhesion peptide labl (cd11a237-246) from the i-domain of lfa-1 via a linker molecule. the h ...	26251760
immunotherapy using lipopolysaccharide-stimulated bone marrow-derived dendritic cells to treat experimental autoimmune encephalomyelitis.	lipopolysaccharide (lps) produced by gram-negative bacteria induces tolerance and suppresses inflammatory responses in vivo; however, the mechanisms are poorly understood. in this study we show that lps induces apoptosis of bone marrow-derived dendritic cells (dcs) and modulates phenotypes of dcs. lps treatment up-regulates expression of tolerance-associated molecules such as cd205 and galectin-1, but down-regulates expression of gr-1 and b220 on cd11c(+) dcs. moreover, lps treatment regulates t ...	25138204
early childhood father absence and depressive symptoms in adolescent girls from a uk cohort: the mediating role of early menarche.	absence of the biological father in early childhood has been linked to depressive symptoms in mid-adolescent girls. earlier studies have linked father absence to early timing of menarche, and early menarche is a risk factor for increased depressive symptoms in adolescence. no studies, however, have examined whether the association between father absence and depressive symptoms may be explained by the early onset of menarche. this study investigated whether age at menarche mediates the associatio ...	25411127
maternal attachment style and responses to adolescents' negative emotions: the mediating role of maternal emotion regulation.	previous research has examined the developmental consequences, particularly in early childhood, of parents' supportive and unsupportive responses to children's negative emotions. much less is known about factors that explain why parents respond in ways that may support or undermine their children's emotions, and even less is known about how these parenting processes unfold with adolescents. we examined the associations between mothers' attachment styles and their distress, harsh, and supportive ...	25568638
evidence of self-informant agreement in ethnic identity.	ethnic identity is considered to be a psychologically important characteristic that is associated with adjustment outcomes. however, little is known about the degree to which ethnic identity manifests itself in characteristics that are observable to others. this study is the first to evaluate self-other agreement in ethnic identity and to use a multi-method approach for testing the associations between ethnic identity and adjustment outcomes. results provide evidence of agreement across self and ...	25422727
can pain and function be distinguished in the oxford hip score in a meaningful way? : an exploratory and confirmatory factor analysis.	the objective of this study was to explore dimensionality of the oxford hip score (ohs) and examine whether self-reported pain and functioning can be distinguished in the form of subscales.	25368370
elements that define recovery: the experiential perspective.	although recovery increasingly guides substance use disorder services and policy, definitions of recovery continue to lack specificity, thereby hindering measure development and research. the goal of this study was to move the substance use disorders field beyond broad definitions by empirically identifying the domains and specific elements of recovery as experienced by persons in recovery from diverse pathways.	25343658
ampakines have novel analgesic properties in rat models of persistent neuropathic and inflammatory pain.	novel analgesics that do not suppress the respiratory drive are urgently needed. glutamate signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (ampa) receptors plays important roles in central pain circuits. ampakines augment ampa receptor function and have been shown to stimulate the respiratory drive to oppose opioid-induced hypoventilation. however, their role in chronic pain states remains unknown.	25338127
annexin a2 regulates trpa1-dependent nociception.	the transient receptor potential a1 (trpa1) channel is essential for vertebrate pain. even though trpa1 activation by ligands has been studied extensively, the molecular machinery regulating trpa1 is only poorly understood. using an unbiased proteomics-based approach we uncovered the physical association of annexin a2 (anxa2) with native trpa1 in mouse sensory neurons. anxa2 is enriched in a subpopulation of sensory neurons and coexpressed with trpa1. furthermore, we observe an increase of trpa1 ...	25355205