Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| bana-positive plaque samples are associated with oral hygiene practices and not cd4+ t cell counts in hiv-positive patients. | background. the "red complex" microorganisms, namely, porphyromonas gingivalis, treponema denticola, and tannerella forsythia are considered as potential pathogens causing hiv-associated periodontal diseases. moreover, it has been recognized that an association exists between cd4+ t cell counts and periodontal disease progression. objective. to establish whether cd4+ t cell counts or oral hygiene plays a greater role in producing bana-positive results in hiv-associated periodontal disease. mater ... | 2012 | 23258979 |
| a phage display selected 7-mer peptide inhibitor of the tannerella forsythia metalloprotease-like enzyme karilysin can be truncated to ser-trp-phe-pro. | tannerella forsythia is a gram-negative bacteria, which is strongly associated with the development of periodontal disease. karilysin is a newly identified metalloprotease-like enzyme, that is secreted from t. forsythia. karilysin modulates the host immune response and is therefore considered a likely drug target. in this study peptides were selected towards the catalytic domain from karilysin (kly18) by phage display. the peptides were linear with low micromolar binding affinities. the two best ... | 2012 | 23119051 |
| glycobiology aspects of the periodontal pathogen tannerella forsythia. | glycobiology is important for the periodontal pathogen tannerella forsythia, affecting the bacterium's cellular integrity, its life-style, and virulence potential. the bacterium possesses a unique gram-negative cell envelope with a glycosylated surface (s-) layer as outermost decoration that is proposed to be anchored via a rough lipopolysaccharide. the s-layer glycan has the structure 4‑meo-b-manpnacconh2-(1→3)-[pse5am7gc-(2→4)-]-b-manpnaca-(1→4)-[4-meo-a-galp-(1→2)-]-a-fucp-(1→4)-[-a-xylp-(1→3 ... | 2012 | 24970146 |
| a bacterial glycan core linked to surface (s)-layer proteins modulates host immunity through th17 suppression. | tannerella forsythia is a pathogen implicated in periodontitis, an inflammatory disease of the tooth-supporting tissues often leading to tooth loss. this key periodontal pathogen is decorated with a unique glycan core o-glycosidically linked to the bacterium's proteinaceous surface (s)-layer lattice and other glycoproteins. herein, we show that the terminal motif of this glycan core acts to modulate dendritic cell effector functions to suppress t-helper (th)17 responses. in contrast to the wild- ... | 2012 | 22968422 |
| energy filtering transmission electron microscopy immunocytochemistry and antigen retrieval of surface layer proteins from tannerella forsythensis using microwave or autoclave heating with citraconic anhydride. | tannerella forsythensis (bacteroides forsythus), an anaerobic gram-negative species of bacteria that plays a role in the progression of periodontal disease, has a unique bacterial protein profile. it is characterized by two unique protein bands with molecular weights of more than 200 kda. it also is known to have a typical surface layer (s-layer) consisting of regularly arrayed subunits outside the outer membrane. we examined the relationship between high molecular weight proteins and the s-laye ... | 2012 | 22984898 |
| fusobacterium nucleatum and tannerella forsythia induce synergistic alveolar bone loss in a mouse periodontitis model. | tannerella forsythia is strongly associated with chronic periodontitis, an inflammatory disease of the tooth-supporting tissues, leading to tooth loss. fusobacterium nucleatum, an opportunistic pathogen, is thought to promote dental plaque formation by serving as a bridge bacterium between early- and late-colonizing species of the oral cavity. previous studies have shown that f. nucleatum species synergize with t. forsythia during biofilm formation and pathogenesis. in the present study, we show ... | 2012 | 22547549 |
| identification of a unique tlr2-interacting peptide motif in a microbial leucine-rich repeat protein. | pathogenesis of many bacterially-induced inflammatory diseases is driven by toll-like receptor (tlr) mediated immune responses following recognition of bacterial factors by different tlrs. periodontitis is a chronic inflammation of the tooth supporting apparatus often leading to tooth loss, and is caused by a gram-negative bacterial consortium that includes tannerella forsythia. this bacterium expresses a virulence factor, the bspa, which drives periodontal inflammation by activating tlr2. the n ... | 2012 | 22695115 |
| occurrence of periodontal pathogens among patients with chronic periodontitis. | the aim of the present study was to evaluate the presence of the periodontal pathogens that form the red complex (tannerella forsythia, porphyromonas gingivalis and treponema denticola) and aggregatibacter actinomycetemcomitans in patients with chronic periodontitis. the sample consisted of 29 patients with a clinical and radiographic diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology (3). samples for microbiological analysis were collected from th ... | 2012 | 24031906 |
| co-localized or randomly distributed? pair cross correlation of in vivo grown subgingival biofilm bacteria quantified by digital image analysis. | the polymicrobial nature of periodontal diseases is reflected by the diversity of phylotypes detected in subgingival plaque and the finding that consortia of suspected pathogens rather than single species are associated with disease development. a number of these microorganisms have been demonstrated in vitro to interact and enhance biofilm integration, survival or even pathogenic features. to examine the in vivo relevance of these proposed interactions, we extended the spatial arrangement analy ... | 2012 | 22655057 |
| serum antibodies to periodontal pathogens are a risk factor for alzheimer's disease. | chronic inflammation in periodontal disease has been suggested as a potential risk factor in alzheimer's disease (ad). the purpose of this study was to examine serum antibody levels to bacteria of periodontal disease in participants who eventually converted to ad compared with the antibody levels in control subjects. | 2012 | 22546352 |
| prevalence of fima genotypes of porphyromonas gingivalis and other periodontal bacteria in a spanish population with chronic periodontitis. | the aim of this study was to determine the prevalence of the different fima genotypes of porphyromonas gingivalis in adult spanish patients with chronic periodontitis, patients with gingivitis and periodontally healthy subjects, and the relationship between these genotypes and other periodontopathogenic bacteria. | 2012 | 22549664 |
| oral bacteria and yeasts in relationship to oral ulcerations in hematopoietic stem cell transplant recipients. | oral mucositis is a serious and debilitating side effect of conditioning regimens for hematopoietic stem cell transplant (hsct). through hsct, the homeostasis in the oral cavity is disrupted. the contribution of the oral microflora to mucositis remains to be clarified. the aim of our study was to investigate the relationship between yeasts, bacteria associated with periodontitis, and oral ulcerations in hsct recipients. | 2012 | 22531876 |
| beta-hexosaminidase activity of the oral pathogen tannerella forsythia influences biofilm formation on glycoprotein substrates. | tannerella forsythia is an important pathogen in periodontal disease. previously, we showed that its sialidase activity is key to utilization of sialic acid from a range of human glycoproteins for biofilm growth and initial adhesion. removal of terminal sialic acid residues often exposes β-linked glucosamine or galactosamine, which may also be important adhesive molecules. in turn, these residues are often removed by a group of enzymes known as β-hexosaminidases. we show here that t. forsythia h ... | 2012 | 22276920 |
| a metalloproteinase karilysin present in the majority of tannerella forsythia isolates inhibits all pathways of the complement system. | tannerella forsythia is a poorly studied pathogen despite being one of the main causes of periodontitis, which is an inflammatory disease of the supporting structures of the teeth. we found that despite being recognized by all complement pathways, t. forsythia is resistant to killing by human complement, which is present at up to 70% of serum concentration in gingival crevicular fluid. incubation of human serum with karilysin, a metalloproteinase of t. forsythia, resulted in a decrease in bacter ... | 2012 | 22287711 |
| analysis of the cell surface layer ultrastructure of the oral pathogen tannerella forsythia. | the gram-negative oral pathogen tannerella forsythia is decorated with a 2d crystalline surface (s-) layer, with two different s-layer glycoprotein species being present. prompted by the predicted virulence potential of the s-layer, this study focused on the analysis of the arrangement of the individual s-layer glycoproteins by a combination of microscopic, genetic, and biochemical analyses. the two s-layer genes are transcribed into mrna and expressed into protein in equal amounts. the s-layer ... | 2012 | 22273979 |
| microflora and periodontal disease. | periodontitis is a disease that affects and destroys the tissues that support teeth. tissue damage results from a prolonged inflammatory response to an ecological shift in the composition of subgingival biofilms. three bacterial species that constitute the red complex group, porphyromonas gingivalis, tannerella forsythia, and treponema denticola, are considered the main pathogens involved in periodontitis. | 2012 | 23814584 |
| evaluation of periodontal pathogens in amniotic fluid and the role of periodontal disease in pre-term birth and low birth weight. | pre-term birth and/or low birth weight (ptlbw) is a serious problem in developing countries. the absence of known risk factors in ≈ 50% of ptlbw cases has resulted in a continued search for other causes. the aim of this study was to examine the effect of periodontitis on pregnancy outcomes. | 2012 | 23638858 |
| periodontal conditions during the pregnancy associated with periodontal pathogens. | to describe the bacterial associations in the periodontal pockets of pregnant women and to correlate the presence of prevotella intermedia, tannerella forsythia (t. forsythia), treponema denticola (t. denticola), aggregatibacter actinomycetemcomitans, and porphyromona gingivalis (p. gingivalis) with periodontal parameters of severity. | 2012 | 23335585 |
| [expression of cytokines in dentogingival sulcus in patients after dental implantation and during development of peri-implantitis]. | determination of cytokine content in various areas of dentition in patients with peri-implantitis associated with parodontopathogenic bacteria species of i and ii order. | 2012 | 23297645 |
| treponema denticola associates with increased levels of mmp-8 and mmp-9 in gingival crevicular fluid. | objectives: the aim was to assess the association between the presence of site-specific subgingival micro-organisms and the levels of matrix metalloproteinases-8 and matrix metalloproteinases-9 (mmp-8 and mmp-9) in gingival crevicular fluid (gcf). materials and methods: the patient group consisted of 56 subjects with periodontitis and the control group of 43 subjects without periodontitis. gcf samples from four test sites for each subject were collected. polymerase chain reaction was used to det ... | 2012 | 23294114 |
| the influence of oral bacteria on tissue levels of toll-like receptor and cytokine mrnas in feline chronic gingivostomatitis and oral health. | feline chronic gingivostomatitis (fcgs) is an inflammatory disease of the oral cavity that causes severe pain and distress in affected cats. treatment methods are currently very limited. the aims of this study were to assess the feline innate immune response by investigating the levels of cytokine and toll-like receptor (tlr) mrnas in tissue biopsies of cats with and without fcgs, and to relate this to the presence or absence of putative oral pathogens identified previously within these cats. mu ... | 2012 | 23287555 |
| validation of a quantitative real-time pcr assay and comparison with fluorescence microscopy and selective agar plate counting for species-specific quantification of an in vitro subgingival biofilm model. | subgingival biofilms are the prime etiological factor of periodontal disease. owing to their complex polymicrobial nature, quantification of individual bacterial species within the biofilm for research and diagnostic purposes can be methodologically challenging. the aims of this study were to establish a quantitative real-time pcr (qpcr) assay to quantify the bacteria used in our 10-species in vitro 'subgingival' biofilm model and to compare the quantitative outcome with fluorescence microscopy ... | 2012 | 23278531 |
| "cross-glycosylation" of proteins in bacteroidales species. | while it is now evident that the two bacteroidales species bacteroides fragilis and tannerella forsythia both have general o-glycosylation systems and share a common glycosylation sequon, the ability of these organisms to glycosylate a protein native to the other organism has not yet been demonstrated. here, we report on the glycosylation of heterologous proteins between these two organisms. using genetic tools previously developed for bacteroides species, two b. fragilis model glycoproteins wer ... | 2012 | 23258847 |
| comparison of microbial changes in early redeveloping biofilms on natural teeth and dentures. | surfaces and fluids can affect oral bacterial colonization. the aim of this study is to compare redeveloping biofilms on natural teeth and dentures. | 2012 | 22443543 |
| impact of periodontal therapy on the subgingival microbiota of severe periodontitis: comparison between good responders and individuals with refractory periodontitis using the human oral microbe identification microarray. | this study compares the changes to the subgingival microbiota of individuals with "refractory" periodontitis (rp) or treatable periodontitis (good responders [gr]) before and after periodontal therapy by using the human oral microbe identification microarray (homim) analysis. | 2012 | 22324467 |
| effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds. | the objective of this paper is to evaluate the effects of oil drops containing lactobacillus salivarius wb21 on periodontal health and oral microbiota producing volatile sulfur compounds (vscs). for this study, 42 subjects were randomly assigned to receive oil samples containing l. salivarius wb21 or a placebo for two weeks. oral assessment and saliva collection were performed on days 1 and 15. bacterial analysis was performed using the real-time polymerase chain reaction and terminal restrictio ... | 2012 | 22368259 |
| a microbiological profile of unexposed and exposed pulp space of primary endodontic infections by checkerboard dna-dna hybridization. | the aim of this study was to evaluate, by checkerboard dna-dna hybridization, the composition of the microbiota of primary endodontic infections in cases associated with exposed (n = 30) and unexposed (n = 30) pulp space. | 2012 | 22703649 |
| reduction of salivary arginine catabolic activity through periodontal therapy. | salivary enzymes may be used to diagnose periodontal conditions. salivary arginase activity (saa) is related to susceptibility to bacterial infection. therefore, the aim of this controlled interventional study was to determine the saa before and after non-surgical periodontal therapy. | 2012 | 23041992 |
| detection and enumeration of periodontopathogenic bacteria in subgingival biofilm of pregnant women. | the aim of this study was to use the fluorescence in situ hybridization (fish) technique to test the hypothesis of qualitative and quantitative differences of 8 periodontopathogens between pregnant and non-pregnant women. this cross-sectional study included 20 pregnant women in their second trimester of pregnancy and 20 non-pregnant women. probing depth, bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque samples were collected and the fish ... | 2012 | 23018230 |
| effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. | emingil g, han b, özdemir g, tervahartiala t, vural c, atilla g, baylas h, sorsa t. the effect of azithromycin, as an adjunct to nonsurgical periodontal treatment, on microbiological parameters and gingival crevicular fluid biomarkers in generalized aggressive periodontitis. j periodont res 2012; 47: 729-739. © 2012 john wiley & sons a/s background and objective: to study the effectiveness of azithromycin in combination with nonsurgical periodontal therapy on clinical and microbiological parame ... | 2012 | 22571226 |
| quantification of subgingival bacterial pathogens at different stages of periodontal diseases. | anaerobic gram-negative oral bacteria such as treponema denticola, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsythia, campylobacter rectus, and fusobacterium nucleatum are closely associated with periodontal diseases. we measured the relative population (bacterial levels) of these oral pathogens in subgingival tissues of patients at different stages of korean chronic periodontal diseases. we divided the individuals into those with chronic gingivitis (g), moder ... | 2012 | 22526568 |
| microbial profiles of patients seeking treatment for periodontitis. influence of origin, smoking and age? | we assessed the potential influence of the origin, the smoking status and the age on subgingival microbial profiles of subjects seeking periodontal care in switzerland today. | 2012 | 22419513 |
| distribution of periodontopathic bacterial species in dogs and their owners. | presently, a large number of individuals consider their companion animals as family members and have close contact with them in daily life. the purpose of the present study was to analyze the distribution of periodontopathic bacterial species in oral specimens taken from dogs and their owners. | 2012 | 22417880 |
| pdt in non-surgical treatment of periodontitis in hiv patients: a split-mouth, randomized clinical trial. | the aim of this study was to evaluate the clinical and microbiological effect of photodynamic therapy (pdt) in the non-surgical treatment of periodontitis in hiv patients. | 2012 | 22407618 |
| [effect of periodontal surgery on the subgingival periodontal microbiota in artificial class iii furcation defects: an experimental study in monkeys]. | this study was to longitudinally evaluate the change of prevalence of five periodontal putative pathogens in the subgingival plaque of artificial class iii furcation defects at the three time-points, including before the establishment of furcation defects, before and 6 months after periodontal surgery. | 2012 | 22353894 |
| azithromycin as an adjunctive treatment of generalized severe chronic periodontitis: clinical, microbiologic, and biochemical parameters. | this study examines the efficacy of azithromycin in combination with non-surgical periodontal therapy on clinical and microbiologic parameters and gingival crevicular fluid (gcf) matrix metalloproteinases-8 (mmp-8) levels over 6 months in patients with severe generalized chronic periodontitis (cp). | 2012 | 22324488 |
| the combination of amoxicillin and metronidazole improves clinical and microbiologic results of one-stage, full-mouth, ultrasonic debridement in aggressive periodontitis treatment. | the aim of the present study is to assess clinical, microbiologic, and immunologic benefits of amoxicillin/metronidazole (am) when performing full-mouth ultrasonic debridement (fmud) in generalized aggressive periodontitis (gagp) treatment. | 2012 | 22288485 |
| anaerobic and microaerophilic pathogens in the biofilm formation on voice prostheses: a pilot study. | voice rehabilitation with voice prostheses is a standard therapy in laryngectomized patients. biofilm formation on the surface of the voice prostheses causes device failure and requires frequent replacements. studies analyzing the biofilm of voice prostheses have mainly focused on aerobic bacteria. anaerobic bacteria as an integral part of the biofilms on voice prostheses have not been investigated yet. | 2012 | 22374743 |
| molecular analysis of 16s rrna genes identifies potentially periodontal pathogenic bacteria and archaea in the plaque of partially erupted third molars. | small subunit rrna sequencing and phylogenetic analysis were used to identify cultivable and uncultivable microorganisms present in the dental plaque of symptomatic and asymptomatic partially erupted third molars to determine the prevalence of putative periodontal pathogens in pericoronal sites. | 2012 | 22326171 |
| protective effect of topical cordia verbenacea in a rat periodontitis model: immune-inflammatory, antibacterial and morphometric assays. | this study evaluated the effects of c. verbenacea essential oil topically administered in a rat periodontitis model. | 2012 | 23171319 |
| screening for periodontopathogenic bacteria in severe chronic periodontitis in a moroccan population. | bacteria play an important role in destructive periodontitis. the aim of this study was to screen for five highly pathogenic bacteria: aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia, and treponema denticola, in moroccan patients presenting with severe chronic periodontitis and to compare results with those of patients presenting with severe aggressive periodontitis. | 2012 | 23141872 |
| possible translocation of periodontal pathogens into the lymph nodes draining the oral cavity. | numerous publications have reported the presence of periodontopathogenic bacteria in peripheral and central vascular lesions. however, it is unclear how this bacterial translocation occurs. the objective of this study was to investigate whether periodontopathic bacteria are translocated to lymph nodes proximal to the oral cavity. obtaining lymph node samples is not ethically feasible unless they are excised as part of the surgical management of patients with cancer. this study analyzed formalin- ... | 2012 | 23124752 |
| quantification of periodontopathic bacteria in saliva using the invader assay. | when quantifying periodontopathic bacteria, it is important to use a convenient method that does not produce false negative results. the invader assay is a convenient method because it does not involve gene amplification. the purpose of this study was to evaluate the validity of the invader assay to quantify periodontopathic bacteria. the invader technology was applied in quantifying five periodontopathic bacteria (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsy ... | 2012 | 22996215 |
| do elderly edentulous patients with a history of periodontitis harbor periodontal pathogens? | the presence of periodontal pathogens in the oral cavity may impact implant survival. therefore, this study aimed to determine the prevalence of campylobacter rectus, porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, prevotella intermedia, tannerella forsythia, treponema denticola, eikenella corrodens, and parvimonas micra in a specific elderly population with a history of periodontitis who have never worn dentures. | 2012 | 22988660 |
| periodontal pathogen load and increased antibody response to heat shock protein 60 in patients with cardiovascular disease. | to determine the relationship between periodontal pathogen load and anti-human heat shock protein 60 (hhsp60) antibodies in patients with established cardiovascular disease (cvd). | 2012 | 22882677 |
| [amalgam, composite and compomer: microbiological study]. | restorative materials have different consequences on the periodontium. the surface of these materials may influence gingival health and cause in some instances gingival inflammation. the purpose of this study was to investigate and compare, in a healthy periodontium, intracrevicular plaque bacteria (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythensis and treponema denticola), at day 0 and at 6 months, around subgingivally located amalga ... | 2012 | 22715643 |
| subgingival microbiota from cebus apella (capuchin monkey) with different periodontal conditions. | this present study evaluated the subgingival microbiota of the cebus apella with different periodontal conditions kept by the tufted capuchin monkey procreation center (são paulo state university - unesp) or free-ranging monkeys. for this purpose, clinical specimens of subgingival biofilm were collected from 52 monkeys, of both genders, 40 kept in captivity and 12 free-ranging monkeys. the primates were submitted to periodontal evaluation and biofilm samples were transferred to vmga iii transpor ... | 2012 | 22710412 |
| a common periodontal pathogen has an adverse association with both acute and stable coronary artery disease. | the aim of this study was to investigate the association between angiographically verified coronary artery disease (cad) and salivary levels of four major periodontal pathogens. | 2012 | 22704805 |
| differential proteomic analysis of a polymicrobial biofilm. | porphyromonas gingivalis, treponema denticola, and tannerella forsythia exist in a polymicrobial biofilm associated with chronic periodontitis. the aim of this study was to culture these three species as a polymicrobial biofilm and to determine proteins important for bacterial interactions. in a flow cell all three species attached and grew as a biofilm; however, after 90 h of culture p. gingivalis and t. denticola were closely associated and dominated the polymicrobial biofilm. for comparison, ... | 2012 | 22808953 |
| does periodontopathic bacterial infection contribute to the etiopathogenesis of the autoimmune disease rheumatoid arthritis? | there is a significant association between rheumatoid arthritis (ra) and periodontal disease (pd). patients with longstanding active ra have been found to have a substantially increased frequency of pd compared with healthy subjects. further, patients with pd have been shown to have a higher prevalence of ra than patients without periodontitis. antibodies to gram-negative, anaerobic periodontal pathogens such as porphyromonas gingivalis, prevotella intermedia, prevotella melaninogenica, and tann ... | 2012 | 22642916 |
| effects of systemic sitafloxacin on periodontal infection control in elderly patients. | to evaluate the microbiological and clinical effects of the systemic administration of sitafloxacin (stfx) on periodontal pockets in elderly patients receiving supportive periodontal therapy (spt). | 2012 | 22616908 |
| [relationship between the preterm low birth weight infant and the periodontal pathogen bacteria in maternal saliva]. | to investigate the possible relationship between the preterm and/or low birth weight (plbw) and three anaerobic microorganisms in saliva of their mothers, including porphyromonas gingivalis (pg), tannerella forsythia (tf), treponema denticola (td). | 2012 | 22353895 |
| quantification of cultivable bacteria and endotoxin in post-treatment apical periodontitis before and after chemo-mechanical preparation. | this clinical study was conducted to quantify cultivable bacteria and endotoxin in root canals with post-treatment apical periodontitis by correlating their levels with clinical features and to evaluate the effect of chemo-mechanical preparation (cmp) with 2 % chlorhexidine gel + 17 % edta on bacterial and endotoxin removal/elimination. moreover, target strict gram-negative anaerobic bacteria were investigated by polymerase chain reaction (pcr). fifteen teeth with post-treatment apical periodont ... | 2012 | 22565224 |
| periodontal disease as a risk factor for rheumatoid arthritis: a systematic review. | the objective of this systematic review is to identify and synthesise the best available evidence to examine whether periodontal disease is a risk factor for rheumatoid arthritis. | 2012 | 27820156 |
| the relationship between turbidity of mouth-rinsed water and oral health status. | the purpose of this study was to examine the relationship between turbidity of mouth rinsed water and oral health status such as dental and periodontal conditions, oral hygiene status, flow rate of saliva and oral bacteria. | 2013 | 22339260 |
| the sociodemographic characteristics, periodontal health status, and subgingival microbiota of patients with chronic periodontitis and type 2 diabetes mellitus: a case-control study in a chinese population. | in china, chronic periodontitis (cp) is common in patients with type 2 diabetes mellitus (t2dm). the purpose of this study is to identify the sociodemographic characteristics associated with such patients and to assess the periodontal health status and subgingival microbiota of patients with cp and t2dm (t2dmcp) in the chinese population. | 2013 | 23030242 |
| the short-term treatment effects on the microbiota at the dorsum of the tongue in intra-oral halitosis patients--a randomized clinical trial. | this study aims to assess the effects of rinsing with zinc- and chlorhexidine-containing mouth rinse with or without adjunct tongue scraping on volatile sulfur compounds (vscs) in breath air, and the microbiota at the dorsum of the tongue. | 2013 | 22573244 |
| clinical, radiographic, microbiological, and immunological outcomes of flapped vs. flapless dental implants: a prospective randomized controlled clinical trial. | the objective of this study was to compare the placement of flapped vs. flapless dental implants utilizing clinical, radiographic, microbiological, and immunological parameters. | 2013 | 22708917 |
| photodynamic therapy in the treatment of class ii furcation: a randomized controlled clinical trial. | to investigate the effect of photodynamic therapy (pdt) as adjunct to mechanical therapy in furcations. | 2013 | 23731242 |
| determining the presence of periodontopathic virulence factors in short-term postmortem alzheimer's disease brain tissue. | the aim of this study was to establish a link between periodontal disease and alzheimer's disease (ad) with a view to identifying the major periodontal disease bacteria (treponema denticola, tannerella forsythia, and porphyromonas gingivalis) and/or bacterial components in brain tissue from 12 h postmortem delay. our request matched 10 ad cases for tissue from brains for dementia research alongside 10 non-ad age-related controls with similar or greater postmortem interval. we exposed svgp12, an ... | 2013 | 23666172 |
| association between il8 haplotypes and pathogen levels in chronic periodontitis. | chronic periodontitis (cp) is considered to be a multifactorial disease influenced by microbial and genetic factors. the aim of the present study was to investigate whether the genetic susceptibility to cp in individuals with the il8 atc/ttc haplotype is associated with subgingival levels of periodontopathogens. sixty-five individuals, grouped according to the presence (n = 28) or absence (n = 37) of the il8 haplotype, were evaluated. after clinical periodontal evaluation, each group was subdivi ... | 2013 | 23660697 |
| [relationships of five periodontal pathogens causing subgingival plaque in patients with chronic periodontitis under different periodontal conditions]. | this study aimed to assess the relationship between the distributions of haemophilus aggregatibacter (h. aggregatibacter ), porphyromonas gingivalis (p. gingivalis ), prevotella intermedia (p. intermedia), tannerella forsythensis (t. forsythensis), and treponema denticola (t. denticola) in subgingival plaque and different periodontal conditions of chronic periodontitis. | 2013 | 24298807 |
| the influence of oral bacteria on epithelial cell migration in vitro. | oral ulcerations often arise as a side effect from chemo- and radiation therapy. in a previous clinical study, porphyromonas gingivalis was identified as a positive predictor for oral ulcerations after hematopoetic stem cell transplantation, possibly incriminating p. gingivalis in delayed healing of the ulcerations. therefore, it was tested whether p. gingivalis and its secreted products could inhibit the migration of oral epithelial cells in an in vitro scratch assay. to compare, the oral bacte ... | 2013 | 24288439 |
| boric acid irrigation as an adjunct to mechanical periodontal therapy in patients with chronic periodontitis: a randomized clinical trial. | the purpose of this single-masked, randomized, controlled clinical trial was to evaluate the effects of boric acid irrigation as an adjunct to scaling and root planing (srp) on clinical and microbiologic parameters and compare this method with chlorhexidine irrigation and srp alone in patients with chronic periodontitis (cp). | 2013 | 23121460 |
| prediction of periodontopathic bacteria in dental plaque of periodontal healthy subjects by measurement of volatile sulfur compounds in mouth air. | the aim of this study was to determine whether measurements of volatile sulfur compounds (vscs) are useful to predict colonization of periodontopathic bacteria. for this purpose, we assessed the relationships among distributions of 4 species of periodontopathic bacteria in tongue coating and dental plaque, oral conditions including vsc concentration in mouth air, and smoking habit of periodontal healthy young subjects. | 2013 | 23107050 |
| a simple mutagenesis using natural competence in tannerella forsythia. | we report the discovery of natural competence in tannerella forsythia and its application to targeted chromosomal mutagenesis. keeping t. forsythia in a biofilm throughout the procedure allowed efficient dna uptake and allelic replacement. this simple method is cost-effective and reproducible compared with the conventional protocols using broth culture and electroporation. | 2013 | 23892061 |
| modification of forsythia detaching factor by gingival crevicular fluid in periodontitis. | forsythia detaching factor (fdf) is a virulence factor of tannerella forsythia detected as a mixture of the 60-kda form of fdf and the 28-kda c-terminal fragment (fdfc). the objective of the present study was to clarify the proteolytic activity of gingival crevicular fluid (gcf) from patients with periodontitis and healthy subjects using recombinant fdf (rfdf) as substrate. | 2013 | 23538166 |
| peripheral arterial disease associated with caries and periodontal disease. | peripheral arterial disease (pad) is an important cardiovascular disorder of the peripheral arteries. chronic infections, such as periodontitis, may play an important role in the etiology and pathophysiology of pad and other cardiovascular conditions. recently, streptococcus mutans has been found with high frequency in atheromatous plaques. the aim of this study is to evaluate the possible clinical and microbiologic association between pad and periodontitis and dental caries. | 2013 | 22680302 |
| clinical and microbiological parameters in patients with self-ligating and conventional brackets during early phase of orthodontic treatment. | to determine the effect of different bracket designs (conventional brackets and self-ligating brackets) on periodontal clinical parameters and periodontal pathogens in subgingival plaque. | 2013 | 22765511 |
| modeling susceptibility to periodontitis. | chronic inflammatory diseases like periodontitis have a complex pathogenesis and a multifactorial etiology, involving complex interactions between multiple genetic loci and infectious agents. we aimed to investigate the influence of genetic polymorphisms and bacteria on chronic periodontitis risk. we determined the prevalence of 12 single-nucleotide polymorphisms (snps) in immune response candidate genes and 7 bacterial species of potential relevance to periodontitis etiology, in chronic periodo ... | 2013 | 23100272 |
| clinical and microbiological changes after minimally invasive therapeutic approaches in intrabony defects: a 12-month follow-up. | this 12-month randomized, controlled trial evaluated the clinical effects and microbiological changes of minimally invasive nonsurgical and surgical approaches for the therapy of intrabony defects. | 2013 | 23053707 |
| frequency of periodontal pathogens in equivalent peri-implant and periodontal clinical statuses. | this study tested the hypotheses that there is: (1) higher bacterial frequency in peri-implantitis/periodontitis, followed by mucositis/gingivitis and peri-implant/periodontal health; (2) similar bacterial frequency between comparable peri-implant and periodontal clinical statuses. | 2013 | 23127822 |
| subgingival aggregatibacter actinomycetemcomitans associates with the risk of coronary artery disease. | we investigated the association between angiographically verified coronary artery disease (cad) and subgingival aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsythia and treponema denticola. | 2013 | 23521427 |
| prevalence of periodontal pathogens and metabolic control of type 1 diabetes patients. | the aim of the study was to evaluate the prevalence of periodontal pathogens aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia and treponema denticola in subgingival plaque collected at different probing depths of type 1 diabetes patients with periodontal disease in correlation to metabolic control. | 2013 | 23413629 |
| influence of periodontal status and periodontopathogens on levels of oral human β-defensin-2 in saliva. | expression patterns of human β-defensin-2 (hbd-2) mrna or hbd-2 protein concentration and periodontal diseases have been a focus of scientific research. this study compares the salivary levels of hbd-2 protein concentration of healthy patients and patients with gingivitis and chronic periodontitis (cp) and correlates these levels with the presence of periodontopathogens. | 2013 | 23173827 |
| [dissertations 25 years after date 37. susceptibility to periodontal diseases]. | in the eighties of the former century it was observed that individuals had different modes of development of periodontitis, largely for unknown reasons. it was assumed that periodontal disease developed as a result of the presence of virulent micro-organisms in combination with an inadequate host response. the concept of this (im)balance in host parasite interactions developed further, in part because of new research techniques. with respect to oral bacteria it was shown that periodontal pathoge ... | 2013 | 24555252 |
| detection of putative periodontopathic bacteria in type 1 diabetic and healthy children: a comparative study. | the aim of this study was to compare and assess the risk of periodontitis due to the presence of four putative periodontopathic bacteria (porphyromonas gingivalis, treponema denticola, tannerella forsythia, and aggregatibacter actinomycetemcomitans) in type 1 diabetic and healthy children. | 2013 | 24025882 |
| characterization of periodontal biofilm in down syndrome patients: a comparative study. | the aim of this study was to characterize the main periodontal bacterial species in down syndrome (ds) patients with and without periodontitis. | 2013 | 23855174 |
| quantification of key periodontal pathogens in insulin-dependent type 2 diabetic and non-diabetic patients with generalized chronic periodontitis. | periodontitis is a common problem in patients with diabetes mellitus (dm), however, differences in the putative periodontal pathogens in subjects with dm compared to non-dm subjects are still inconclusive. the red complex, which includes porphyromonas gingivalis, treponema denticola, and tannerella forsythia, encompasses the most important pathogens in adult periodontal disease. the aim of the present study was to compare cell numbers of p. gingivalis, t. denticola, t. forsythia and aggregatibac ... | 2013 | 23827459 |
| clinical and microbiologic effect of nonsurgical periodontal therapy on patients with chronic or aggressive periodontitis. | to evaluate the changes in the clinical parameters, and the prevalence and quantities of three major periodontopathic bacteria, namely porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, and tannerella forsythia, in subgingival plaque collected from patients with generalized chronic periodontitis (gcp) or generalized aggressive periodontitis (gagp) in response to nonsurgical periodontal therapy. | 2013 | 23757461 |
| rheumatoid arthritis is an autoimmune disease caused by periodontal pathogens. | a statistically significant association between periodontal disease (pd) and systemic diseases has been identified. rheumatoid arthritis (ra), which is a chronic inflammatory joint disease, exhibits similar characteristics and pathogenesis to pd. the association between ra and pd has been investigated, and numerous publications on this subject exist. approximately 20 bacterial species have been identified as periodontal pathogens, and these organisms are linked to various types of pd. the most a ... | 2013 | 23737674 |
| porphyromonas gingivalis, treponema denticola and toll-like receptor 2 are associated with hypertensive disorders in placental tissue: a case-control study. | to explore the associations between the presence of periodontal pathogens and the expression of toll-like receptors (tlr-2 and tlr-4) in the placental tissue of patients with hypertensive disorders compared to the placentas of healthy normotensive patients. | 2013 | 23711357 |
| a randomized controlled clinical trial on the clinical and microbiological efficacy of systemic satranidazole in the treatment of chronic periodontitis. | the present clinical trial was designed to investigate the effectiveness of systemic satranidazole (sz) as an adjunct to scaling and root planing (srp) in the treatment of chronic periodontitis. | 2013 | 23705535 |
| prevalence of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and tannerella forsythia in japanese patients with generalized chronic and aggressive periodontitis. | this study aimed to investigate the prevalence and levels of major periodontal pathogens, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and tannerella forsythia in subgingival plaque samples of a group of japanese patients with aggressive periodontitis (agp) and chronic periodontitis (cp). a total of 40 patients with clinical diagnosis of agp or cp and 10 periodontally healthy volunteers were subjected to clinical and microbiological analysis. subgingival plaque samples were an ... | 2013 | 23608307 |
| detection of oral bacterial dna in synovial fluid. | as periodontal bacteria might be involved in the aetiology of rheumatic diseases, we analysed synovial fluid obtained from patients with rheumatoid arthritis (ra) and controls for the presence of dna of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, prevotella intermedia, tannerella forsythia, and treponema denticola. | 2013 | 23534379 |
| the effects of stress hormones on growth of selected periodontitis related bacteria. | the focus of this study was to examine in vitro the effects of stress hormones (catecholamines: epinephrine, norepinephrine, dopamine and hydrocortisone: cortisol) on the growth of four anaerobic species of periodontitis-related bacteria (fusobacterium nucleatum, porphyromonas gingivalis, prevotella intermedia and tannerella forsythia) and one facultative anaerobic species (eikenella corrodens). bacterial growth was determined by two different methods: fluorescence in situ hybridization (fish), ... | 2013 | 24036419 |
| oral microbiota in swiss adolescents. | the purpose of the study was to determine the prevalence of different oral microbes in gingival plaque samples and in samples from the dorsum of the tongue in a swiss adolescent population. | 2013 | 22371122 |
| subgingival microbial profiles as diagnostic markers of destructive periodontal diseases: a clinical epidemiology study. | to describe the subgingival microbial profiles of the major putative periodontal pathogens and investigate their role as diagnostic markers for destructive periodontal diseases in an untreated and isolated population. | 2013 | 22564019 |
| a double-blind randomized placebo-controlled study on the clinical and microbial effects of an essential oil mouth rinse used by patients in supportive periodontal care. | this 3-month double-blind randomized placebo-controlled study evaluated the clinical and microbial effects of an essential oil mouth rinse used as an adjunct to mechanical plaque control by patients in supportive periodontal care. | 2013 | 22998386 |
| clinical and microbiological results following nonsurgical periodontal therapy with or without local administration of piperacillin/tazobactam. | we assessed if adjunct administration of piperacillin/tazobactam added clinical and microbiological treatment benefits. | 2013 | 23334268 |
| presence of oral bacterial species in primary endodontic infections of primary teeth. | knowledge of the microbial composition of deciduous endodontic infections is limited. this study aimed to evaluate the presence of the 10 oral bacterial species in samples from primary tooth root canals by using microarray technology and to determine the association of these organisms with clinical conditions. | 2013 | 24683780 |
| autoinducer 2 of fusobacterium nucleatum as a target molecule to inhibit biofilm formation of periodontopathogens. | periodontitis is initiated by bacteria in subgingival biofilms, which are composed mostly of gram-negative anaerobes. autoinducer 2 (ai-2) is a universal quorum sensing (qs) molecule that mediates intergeneric signalling in multispecies bacterial communities and may induce biofilm formation. as fusobacterium nucleatum is the major coaggregation bridge organism that links early colonising commensals and late pathogenic colonisers in dental biofilms via the accretion of periodontopathogens, we hyp ... | 2013 | 22633049 |
| protein substrates of a novel secretion system are numerous in the bacteroidetes phylum and have in common a cleavable c-terminal secretion signal, extensive post-translational modification, and cell-surface attachment. | the secretion of certain proteins in porphyromonas gingivalis is dependent on a c-terminal domain (ctd). after secretion, the ctd is cleaved prior to extensive modification of the mature protein, probably with lipopolysaccharide, therefore enabling attachment to the cell surface. in this study, bioinformatic analyses of the ctd demonstrated the presence of three conserved sequence motifs. these motifs were used to construct hidden markov models (hmms) that predicted 663 ctd-containing proteins i ... | 2013 | 24007199 |
| long-term follow-up of turned single implants placed in periodontally healthy patients after 16 to 22 years: microbiologic outcome. | survival rates in implant dentistry today are high, although late failures do occur for many reasons, including peri-implant infections. the primary objective of this study is to investigate microbiota around single turned implants after 16 to 22 years. secondary objectives are to compare teeth and implants and to correlate microbiologic, radiographic, and clinical parameters. | 2013 | 22934839 |
| microbiological effect of essential oils in combination with subgingival ultrasonic instrumentation and mouth rinsing in chronic periodontitis patients. | thirty chronic periodontitis patients were randomly assigned to 3 groups: control, saline, and essential oil-containing antiseptic (eo). subgingival plaque was collected from a total of 90 pockets across all subjects. subsequently, subgingival ultrasonic instrumentation (sui) was performed by using eo or saline as the irrigation agent. after continuous mouth rinsing at home with eo or saline for 7 days, subgingival plaques were sampled again. periodontopathic bacteria were quantified using the m ... | 2013 | 24171000 |
| pathogen levels and clinical response to periodontal treatment in patients with interleukin 8 haplotypes. | the aim of this study was to investigate the effect of non-surgical treatment of periodontitis on the levels of periodontopathogens and clinical parameters in patients with different genetic backgrounds produced by polymorphisms in the interleukin ( il8) gene. thirty patients grouped according to il8 atc/ttc or agt/ttc haplotypes were submitted to non-surgical periodontal treatment. levels of porphyromonas gingivalis, tannerella forsythia, and treponema denticola were determined in 240 subgingiv ... | 2013 | 23821559 |
| [detection of periodontal pathogens from saliva of type 2 diabetic patients in urban area of beijing]. | to investigate the prevalence of periodontal pathogens from saliva of patients with type 2 diabetes mellitus (t2dm), and to characterize the association between the glucose status and periodontal pathogens in oral cavity. | 2013 | 23751528 |
| periodontopathogens levels and clinical response to periodontal therapy in individuals with the interleukin-4 haplotype associated with susceptibility to chronic periodontitis. | periodontitis is an inflammatory disease that results from an interaction between dental biofilm agents and the host immune-inflammatory response. periodontopathogenic organisms, such as porphyromonas gingivalis, tannerella forsythia, and treponema denticola, as well as the host's susceptibility, represented by the host's genetic makeup, are the key factors that influence this complex disease. recently, we identified haplotypes in the il4 gene that were associated with chronic periodontitis (cp) ... | 2013 | 23748736 |
| clinical, microbiologic, and host response characteristics in patients with peri-implant mucositis. | to analyze the clinical, microbiologic, and host response characteristics (interleukins 1β and 6) in the peri-implant sulcus fluid (pisf) of patients with healthy dental implants and with peri-implant mucositis. | 2013 | 23748323 |
| association of plasma 25-hydroxyvitamin d concentrations and pathogenic oral bacteria in postmenopausal females. | previous findings of an association between 25-hydroxyvitamin d [25(oh)d] concentrations and periodontal disease may be partially explained by the antimicrobial properties of vitamin d. to the best of the authors' knowledge, no study has investigated the association between 25(oh)d and pathogenic oral bacteria, a putative cause of periodontal disease. | 2013 | 24261910 |