Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| leads from the mmwr. update: prevention of haemophilus influenzae type b disease. | 1988 | 3336191 | |
| efficacy of sequential annual vaccination with inactivated influenza virus vaccine. | inactivated influenza virus vaccine efficacy after annual revaccination has been reported to be less than that after first vaccination in boarding school children. we prospectively examined the immunogenicity and efficacy of this vaccine in healthy 30- to 60-year-old volunteers in houston, texas, over two epidemic seasons (1983-1985) encompassing outbreaks due to influenza a (h3n2 and h1n1) and influenza b viruses. a placebo group that had never (or not in recent years) received inactivated infl ... | 1988 | 3337087 |
| immunization of elderly people with high doses of influenza vaccine. | healthy ambulatory elderly were immunized with increasing doses of the 1984-1985 influenza vaccine formulation. two types of vaccines, split-product vaccine (spv) and whole virus vaccine (wvv), were used. three different doses, 0.5 ml (the standard volume, 1x), or 1.0 ml (2x), and 1.5 ml (3x) of each of the two vaccines were compared. the size of each of the six groups was between 23 and 26 subjects. the mean ages in each of the groups ranged from 71 to 74 years. no difference in local or system ... | 1988 | 3339228 |
| inhibition of fatty acid beta oxidation by influenza b virus and salicylic acid in mice: implications for reye's syndrome. | injection of concentrated influenza b/lee/40 virus into 4-week-old balb c mice resulted in 60% inhibition of 14c-palmitate oxidation in isolated hepatic mitochondria. oral feeding of carnitine to infected mice prevented the inhibition of fatty acid oxidation. high concentrations of salicylic acid given orally also inhibited 14c-palmitate oxidation. serum free fatty acid concentrations of infected mice and of those fed salicylic acid were significantly higher than in control mice. a combination o ... | 1988 | 3340286 |
| antibody response in humans to influenza virus type b host-cell-derived variants after vaccination with standard (egg-derived) vaccine or natural infection. | hemagglutination inhibition (hi) and neutralization tests were used to determine antibody responses to egg-derived and madin-darby canine kidney (mdck)-derived influenza b virus (b/england/222/82) in paired sera from persons naturally infected with influenza b and in persons vaccinated with standard egg-derived inactivated influenza vaccine. when tested by hi, the mdck-derived antigen gave significantly higher (8- to 12-fold) geometric mean titers (gmt) in convalescent-phase sera from persons na ... | 1988 | 3343328 |
| acute respiratory illness among immunized and nonimmunized patients with high-risk factors during a split season of influenza a and b. | a prospective survey of acute respiratory illness (ri) was made among 329 vaccinated and unvaccinated ambulatory patients with high-risk factors for influenza. surveillance for virus during the influenza season revealed the predominance of influenza a and b in sequential periods. during the influenza a period, febrile ri was greatest among patients with chronic pulmonary disease; among 66 patients, vaccination significantly reduced ri. age greater than 65 y (199 patients) and heart (90 patients) ... | 1988 | 3346562 |
| influenza virus-model membrane interaction. a morphological approach using modern cryotechniques. | the membrane fusion activity of influenza virus was characterized morphologically using a model system composed of a highly purified influenza b virus suspension and ganglioside-containing zwitterionic liposomes. electron microscopical analysis was performed after a combination of fast-freezing with either freeze-fracture or freeze-substitution-thin sectioning, ensuring maximal time resolution and avoiding preparation artifacts. in a parallel fluorescence 'lipid mixing' fusion assay, influenza v ... | 1988 | 3349083 |
| sequence comparison of wild-type and cold-adapted b/ann arbor/1/66 influenza virus genes. | consensus sequences for both wt and ca b/ann arbor/1/66 viral pb2, pb1, pa, np, m, and ns genes were directly determined from vrna using a combination of chemical and chain-termination sequencing methods. there were 105 sites of difference between the wt and ca sets of these six rna genes. the differences resulted in 26 amino acid substitutions distributed over the six proteins. the sequence changes were compared to the sequences of other known influenza type b wt viruses to pinpoint those chang ... | 1988 | 3354202 |
| a mutation in the pa protein gene of cold-adapted b/ann arbor/1/66 influenza virus associated with reversion of temperature sensitivity and attenuated virulence. | reassortant sg3 inherits only the acidic polymerase (pa) protein gene from the cold-adapted b/aa/1/66 influenza virus (ca b/aa/1/66) and all remaining genes from a virulent, wild-type virus. this reassortant demonstrates attenuated virulence in ferrets and expresses a ts phenotype characteristic of the ca parent. during virulence evaluation of sg3, a virulent, non-ts revertant virus (designated sg3rfl) was isolated from the lungs of one ferret. in order to determine whether the reversion of sg3 ... | 1988 | 3354203 |
| serological examination of ige- and igg-specific antibodies to egg protein during influenza virus immunization. | the concentrations of serum ige (prist) and ige- and igg-specific antibodies to egg protein were determined in paired sera taken from students who had received influenza virus vaccine. although persons who gave a history of allergy to egg or to chicken feathers were excluded, 10-16% of vaccinees possessed higher titres of serum ige and ige-specific antibody (rast) to egg white (f1) allergen before vaccination. the titres of igg-specific antibody to egg protein (ovalbumin and ovomucoid antigens) ... | 1988 | 3356225 |
| crystallization and preliminary x-ray analyses of two neuraminidases from influenza b virus strains b/hong kong/8/73 and b/lee/40. | crystals of neuraminidase heads from two different influenza b virus strains have been grown. neuraminidase crystals of influenza b/hong kong/8/73 were grown from solutions of potassium phosphate. the crystals are tetragonal prisms, space group i422; the axes are a = 123 a and c = 165 a. influenza b/lee/40 neuraminidase crystals were grown from solutions of polyethylene glycol 4000. the crystals are tetragonal pyramids, space group p4(1)2(1)2 or its enantiomorph p4(3)2(1)2; the axes are a = 125 ... | 1988 | 3360786 |
| the effects of experimentally induced respiratory virus infections on performance. | studies of experimentally induced respiratory infections and illnesses showed that influenza impaired performance on a visual search task but had no effect on a simple motor task, whereas colds impaired the motor task but not the search task. the effect of influenza on the search task was observed in both volunteers with significant clinical symptoms and volunteers who were shown, by virological techniques, to be infected but who had no significant clinical illness. performance was also impaired ... | 1988 | 3363045 |
| polylactosaminoglycan modification of a small integral membrane glycoprotein, influenza b virus nb. | the structure of the carbohydrate components of nb, the small integral membrane glycoprotein of influenza b virus, was investigated. the carbohydrate chains of nb are processed from the high-mannose form (nb18) to a heterogeneous form of much higher molecular weight, designated nbp. selection of this carbohydrate-containing form of nb with datura stramonium lectin, its susceptibility to digestion by endo-beta-galactosidase, and determination of the size of nbp glycopeptides by gel filtration chr ... | 1988 | 3367907 |
| intact humoral immune response in patients on continuous ambulatory peritoneal dialysis. | after influenza vaccination no statistically significant difference in antibody response was observed between patients on continuous ambulatory peritoneal dialysis (capd) and healthy volunteers while a large group of hemodialysis (hd) patients was found to have a significantly lower response rate. this difference remained statistically significant when capd patients were compared to a matched hd group. as the antibody formation after influenza vaccination is a t cell-dependent phenomenon, the no ... | 1988 | 3380215 |
| antibody response of an elderly population to a supplemental dose of influenza b vaccine. | recent reports have suggested that the antibody response of elderly persons to standard doses of influenza vaccine is depressed. we examined the effect of an additional threefold dose of influenza b vaccine on the antibody response in elderly, ambulatory veterans. one hundred thirty-one male subjects aged 70 years and older were randomized to receive one of three influenza vaccine regimens: group i received standard trivalent influenza vaccine containing 15 micrograms of b/ussr/100/83 in one arm ... | 1988 | 3385111 |
| cardiac tamponade caused by influenza b. | 1988 | 3393254 | |
| adverse reactions to equine vaccinations: a preliminary survey. | 1988 | 3394223 | |
| [analysis of the associative relations of hla-antigens with the intensity of production of certain antimicrobial antibodies]. | 1988 | 3396837 | |
| influenza prevention, 1988-1989. | 1988 | 3405128 | |
| failure of influenza vaccination in the aged. | a cohort of 127 nursing home residents aged 60-98 years were vaccinated during the winter of 1985-86 with the a-chile 1/83 (c), a-philippines 2/82 (p), and b-ussr (b) commercial influenza vaccines. before vaccination 40%, 23%, and 69% were susceptible to influenza ac, ap, and b, respectively [hemagglutinin inhibition (h.i.) titer less than 1:40]. one month following initial vaccination, 32 patients [25%] remained unprotected against two or all three vaccine strains. these patients were revaccina ... | 1988 | 3411310 |
| [effect of the matrix protein of the influenza virus on oxidative phosphorylation in preparations of isolated liver mitochondria from white mice]. | the effect of matrix proteins (m proteins) of influenza a/mrc-11 and b/lee viruses on oxidative phosphorylation in preparations of isolated mitochondria of white mice liver was studied. m proteins were shown to cause disorders in the system of oxidative phosphorylation leading to reduction of the coefficient of respiratory control and amplification coefficient recorded by the polarographic method. it was also shown that an anti-influenza compound 2-(1'-aminoethyl)-bicyclo(2.2.1)heptane hydrochlo ... | 1988 | 3414064 |
| reye's syndrome-like illness in a patient receiving amiodarone. | a 16-yr-old boy who was receiving amiodarone for ventricular arrhythmias developed a reye's syndrome-like illness several days after an upper respiratory infection. liver biopsy revealed microvesicular fat and spotty hepatocellular necrosis, typical of reye's syndrome. recovery was complete. this case report suggests that medications other than aspirin may predispose to reye's syndrome, and that children receiving amiodarone should receive prophylaxis against influenza b and chicken pox. | 1988 | 3414648 |
| comparative activities of several nucleoside analogs against influenza a, b, and c viruses in vitro. | a set of 20 nucleoside analogs were examined for their inhibitory effects on the cytopathogenicity and growth of influenza virus type a, b, and c strains in madin-darby canine kidney (mdck) cells. among the compounds evaluated, pyrazofurin, 3-deazaguanine, ribavirin, carbodine, and cyclopentenyl cytosine inhibited viral cytopathogenicity at concentrations that were lower than those found cytotoxic for the mdck cells. no differences were observed in the 50% effective doses (based on inhibition of ... | 1988 | 3415210 |
| recommendations of the immunization practices advisory committee, centers for disease control. prevention and control of influenza. | these recommendations update information on the vaccine and antiviral agent available for controlling influenza during the 1988-89 influenza season (superseding mmwr 1987;36:373-380,385-387). changes include statements about 1) updating of the influenza strains in the trivalent vaccine for 1988-89, 2) increased emphasis on the need for vaccination of health-care workers, 3) prevention of influenza in persons with human immunodeficiency virus (hiv) infection, and 4) dosage considerations for aman ... | 1988 | 3171036 |
| [structural dynamics of strains of a hepatitis b virus population in the ukraine and its etiological prognosis]. | changes in the population structure of influenza b virus in the ukraine since 1980 has been studied. new strains of the virus have been identified and the epidemic potentials of different strains have been compared. the data on the drift mechanism of the origin of the intermediate strains of influenza b virus have been observed. a suggestion on the etiological prognostication of the epidemic process has been made. | 1988 | 3176781 |
| [clinical picture and diagnosis of influenza]. | 1988 | 3181466 | |
| determination of antibody response to influenza virus surface glycoproteins by kinetic enzyme-linked immunosorbent assay. | we modified an existing enzyme-linked immunosorbent assay (elisa) to be able to use new spectrophotometers which can measure the rate of color development in microtiter wells. this new kinetic-based elisa (kelisa) required only a single dilution of specimen rather than the multiple dilutions required with endpoint elisa. in addition, 10- to 100-fold-less specimen was required to perform the kelisa than the elisa. the level of serum or nasal wash antibody against surface glycoproteins of influenz ... | 1988 | 3182992 |
| epidemiologic features of influenza in a large urban centre (b.) in romania, in 1987. | the study presents the peculiarities of influenza evolution in 1987 in a large town in romania. these features were defined by a complex methodology, based on clinical, epidemiologic and laboratory investigations, used in the active control of the epidemiologic process kinetics. the influenza viruses type a (h1n1 and h3n2) had a major role in the infecting and immunizing contacts in all age groups whereas the influenza virus type b had a reduced circulation. the epidemiologic influenza impact in ... | 1988 | 3195054 |
| [surveillance of antibodies to human influenza a and b virus in swine population in different seasons in chengdu]. | 1988 | 3198101 | |
| crystallization and preliminary x-ray analysis of type b influenza virus neuraminidase complexed with antibody fab fragments. | fab fragments from four different monoclonal antibodies have been complexed with influenza b virus neuraminidase (b/lee/40) and the complexes have been crystallized. three of the complex crystals are, so far, not suitable for x-ray diffraction studies, but the fourth (b/lee/40 na-b1fab) forms large crystals which diffract x-rays to 3.0 a resolution. the crystals have a space group of f432, a = 441.21 a. vm calculations show that the asymmetric unit contains two monomeric complexes. | 1988 | 3201756 |
| surveillance of influenza a and b viruses in italy between 1984 and 1987. | antigenically heterogeneous strains and new variants of influenza a viruses, both a (h3n2) and (h1n1) subtypes, as well as influenza b strains were detected in italy in a period, between 1984-1987, characterized by a moderate degree of influenza activity. each year the evaluation, by srh technique, of antibodies, in the population, to currently circulating viruses, has confirmed the extent of infection and often the prevalent virus. | 1988 | 3203724 |
| evolution of influenza polymerase: nucleotide sequence of the pb2 gene of a/chile/1/83 (h1 n1). | the complete nucleotide sequence of the pb2 gene of influenza virus a/chile/1/83 (h1 n1) is presented. sequence comparison between a/chile pb2 protein and the known pb2 sequences of the influenza strains a/wsn/33 (h1 n1), a/pr/8/34 (h1 n1), a/nt/60/68 (h3 n2), a/kiev/59/79 (h1 n1), a/fpv/rostock/34 (h7 n1), and b/ann arbor/1/66 indicates extensive amino acid homology for the influenza a virus pb2 proteins. small clusters of basic amino acids are conserved in all pb2 proteins including the influe ... | 1988 | 3214273 |
| analysis of the mechanism of influenza b virus inactivation by guinea pig serum. | normal guinea pig serum lacking detectable antiviral antibody inactivated influenza b virus via the classical complement pathway. this virus inactivation appeared to result from the steric hindrance of ha activity by the association with the virus of serum proteins presumed to be complement components. trypsin digestion of the associated proteins fully restored the ha activity but not infectivity. it was found that the virus underwent minor disruption of the envelope and degradation of m1 protei ... | 1988 | 3214275 |
| [use of recombinants for preparing erythrocyte antibody diagnostic agents for influenza viruses]. | 1988 | 3218216 | |
| [the epidemic spread of the influenza a and b viruses in the ussr in 1985-1986]. | the data on the spread of influenza a and b in the autumn and winter of 1985-1986 are given. three epidemics caused by all presently circulating viruses, b, a (h3n2) and a (h1n1), were registered in the ussr. of these, the greatest one was the epidemic of influenza b; morbidity rate among the adult population during this epidemic was at the level with the morbidity rate characteristic of the epidemics registered at the period of 1962-1972, and morbidity rate among children, especially school chi ... | 1988 | 3218423 |
| post-influenzal psychiatric disorder in adolescents. | the association between influenza and psychiatric disorder in adolescents was studied at a time when both were highly prevalent concurrently. first 505 secondary school pupils aged 15-18 completed questionnaires, including a symptom inventory derived from the scl-90-r. subsequently, 113 blood samples were examined for influenza antibody titers of five virus strains. statistical analysis showed that adolescents who had been ill with influenza in the previous six months had significantly more psyc ... | 1988 | 3223316 |
| [acute pneumonia complicating influenza]. | 1988 | 3227458 | |
| influenza activity--canada, 1987-88 season. | 1988 | 3233675 | |
| a summary of influenza activity in canada--1986-1987 season. | 1988 | 3233676 | |
| diurnal variation in the symptoms of colds and influenza. | the present research examined diurnal variation in the severity of symptoms of experimentally-induced colds and influenza. nasal secretion was greatest in the morning, decreased over the day, and then showed a slight increase in the late evening. colds did not change the average temperature, nor did they alter the temperature rhythm. similar, negative results were found with alertness ratings. influenza b illnesses produced an increase in nasal secretion and systemic effects. the average tempera ... | 1988 | 3233696 |
| [study of an influenza epidemic in tananarive (february 1987)]. | 1988 | 3242424 | |
| laboratory evidence of influenza in canada. | 1988 | 3242872 | |
| national advisory committee on immunization (naci). statement on influenza vaccination for the 1988-1989 season. | 1988 | 3242878 | |
| influenza b outbreak at a canadian forces base--nova scotia. | 1988 | 3242879 | |
| probable outbreak of influenza b in a nursing home--ontario. | 1988 | 3242880 | |
| influenza virus activity in canada. | 1988 | 3242890 | |
| influenza b outbreak in a home for the aged--ontario. | 1988 | 3242892 | |
| influenza b outbreak in a nursing home--alberta. | 1988 | 3242903 | |
| antigenic analysis of influenza a and b viruses. | 1988 | 3242905 | |
| [the antiviral action of a polyphenol complex isolated from the medicinal plant geranium sanguineum l. vi. reproduction of the influenza virus pretreated with the polyphenol complex]. | 1988 | 3247856 | |
| [the combined action of glycosylation inhibitors on the influenza virus in ehrlich ascites tumor cells]. | 1988 | 3247866 | |
| the effect of vitamin a on some biological properties of type b influenza virus. | 1988 | 3250361 | |
| influenza surveillance in singapore: 1972-86. | prospective laboratory surveillance of influenza viruses has been carried out since 1973 in singapore. the results indicate that antigenic shift variants caused epidemics at various times of the year over this period, whereas drift variants were associated with a regular increase in incidence during the second and fourth calendar quarters. outbreaks due to influenza a virus occurred every year and to influenza b virus at intervals of 16-24 months. between outbreaks, viruses belonging to either o ... | 1988 | 3260142 |
| laboratory evidence of influenza in canada. | 1988 | 3266571 | |
| a summary of influenza activity in canada, 1987-1988 season. | 1988 | 3266585 | |
| influenza b virus evolution: co-circulating lineages and comparison of evolutionary pattern with those of influenza a and c viruses. | sequence analyses and comparison of the genes coding for the nonstructural (ns) and hemagglutinin (ha) proteins of different influenza b viruses isolated between 1940 and 1987 reveal that the number of substitutions is not always proportional to the time between isolates. examination of 14 influenza b virus ns gene and 10 ha gene sequences by the maximum parsimony method suggested that--as with influenza c viruses--there are multiple evolutionary lineages which can coexist for considerable perio ... | 1988 | 3267218 |
| sequence analysis of the hemagglutinin of b/ann arbor/1/86, an epidemiologically significant variant of influenza b virus. | influenza b/ann arbor/1/86 is representative of antigenic variants responsible for the most important influenza epidemics during the 1985/1986 season. the nucleotide sequence of the hemagglutinin ha1 region and the deduced amino acid sequence are presented. compared to the previous winter's vaccine strain b/ussr/100/83, b/aa/1/86 possesses 18 amino acid substitutions and 2 amino acid insertions, 50% of which are distributed within the vicinity of the reported single immunodominant antigenic site ... | 1988 | 3267231 |
| [immunoenzyme test system based on antibody f(ab)2-fragments for detecting the np protein of the influenza virus]. | a test system has been proposed for the detection of influenza a virus np protein by solid-phase enzyme immunoassay in a modified system of "double" antibodies: the primary antibodies were f(ab)2-fragments of immunoglobulin class g isolated from rabbit antiserum specific for np protein which was also used as the source of secondary antibodies. the antigen-bound antibodies were detected by protein a (from st. aureus) conjugate with horseradish peroxidase. the high specificity and sensitivity of t ... | 1988 | 3285591 |
| a placebo-controlled dose response study of the reactogenicity and immunogenicity of a live cold-recombinant influenza b virus vaccine in healthy volunteers. | a live cold-recombinant influenza b virus vaccine (rb77) was given intranasally in a placebo-controlled, double blind study to volunteers in dosages of 10(7.9) eid50/ml, 10(7.25) eid50/ml, 10(5.7) eid50/ml. the tolerability, safety, and immunogenicity of the vaccine were investigated. no revertant virus was found in nasal swabs taken after immunisation. local reactions were mild and showed a significant increase over the placebo only in the highest dose group. systemic reactions were not differe ... | 1988 | 3292699 |
| ribavirin small-particle-aerosol treatment of influenza b virus infection. | in a randomized double-blind trial of aerosolized ribavirin for the treatment of influenza b virus infection, no significant difference was found in the febrile course or symptom score of the ribavirin-treated versus placebo-treated patients. the apparent lack of efficacy in this study as compared with that in previous studies is unexplained. | 1988 | 3293527 |
| update: influenza activity--united states. | 1988 | 3122012 | |
| update on influenza activity--united states and worldwide, with recommendations for influenza vaccine composition for the 1988-89 season. | 1988 | 3127677 | |
| influenza--united states, 1987-88 season. | 1988 | 3135481 | |
| update: influenza--united states, 1988-89 season. | 1988 | 3141771 | |
| [identification of the antigenic components of the host cell in isolated glycoproteins of the influenza virus]. | immunological analysis performed by solid-phase enzyme immunoassay and complement fixation test revealed the presence of host cell antigenic components in purified intact influenza virions and isolated hemagglutinins and glycoproteins. three antigens inherent to chick embryo cells were identified in virus preparations: the species-specific antigen, heterogenetic forssman antigen, and one similar to human group a antigen. antisera to purified whole-virion influenza vaccines, to glycoproteins and ... | 1988 | 2461614 |
| [comparison of anti-influenza vaccines: whole adsorbed trivalent, trivalent subunit and tetravalent subunit]. | two different sub-unit polyvalent vaccines have been compared with the trivalent whole virus adsorbed vaccine, in two different groups of people, including both sexes, aging between 20 and 60 yrs. and between 65 and 85 yrs. respectively. our findings show that all the three vaccines induced high seroconversion rates against the subtypes a/mississippi/1/85 and a/chile/1/83. as to the strain b/ann arbor/1/86 the sub-unit vaccine induced significantly higher seroconversion rates then the whole viru ... | 1988 | 2482767 |
| rapid diagnosis of influenza a and b by 24-h fluorescent focus assays. | murine monoclonal antibodies directed against type-specific antigens of influenza a and b viruses have been shown to be useful diagnostic reagents for the detection of influenza viruses by immunofluorescence testing of nasopharyngeal cells. we have developed fluorescent focus assays utilizing these antibodies in cell culture chamber slides and shell vials for the rapid diagnosis of influenza a and b. chamber slide assays were compared with virus isolation in 160 specimens from 135 patients with ... | 1988 | 3045148 |
| laboratory and epidemiologic assessment of a recent influenza b outbreak. | a viral surveillance system in nashville detected an outbreak of influenza b that occurred between january and march 1986. paired sera from 32 individuals with culture-documented influenza b illness were tested using three serologic assays. enzyme-linked immunosorbent assay (elisa) using purified hemagglutinin-neuraminidase and plaque neutralization detected a seroresponse in 69% and 66% of these individuals, respectively. these assays were superior to hemagglutination inhibition, which detected ... | 1988 | 3049940 |
| an improved membrane-filtration enzyme immunoassay for the rapid serological diagnosis of viral infections. | a one-step modification of the membrane-filtration enzyme immunoassay (mf eia) (barnett et al., j. clin. microbiol., 23:385-399, 1987), for estimation of virus-specific antibody is described. the modified mf eia allowed serum, antigen and enzyme-conjugated anti-globulin to be incubated together in membrane-based 96-well plates to enable the formation of immune complexes in solution at 37 degrees c. the assay required only 45 min for completion and polyethylene glycol was shown to be an essential ... | 1988 | 3053742 |
| [identification of the hemagglutinating antigens of the influenza virus by immunoenzyme analysis]. | highly active test sera detecting the presence of virus antigen both in concentrated and purified preparations and in allantoic virus cultures directly adsorbed on the solid phase have been proposed for successful identification and detection of influenza a and b virus variants. after direct sorption of purified and concentrated virus preparations, the test sera to influenza a (h1n1, h2n2, h3n2) virus detect the virus antigen in a concentration of 8 ng/ml, test sera to influenza b virus in a con ... | 1988 | 3064428 |
| [isolation and characteristics of monoclonal antibodies to influenza virus types a and b]. | monoclonal antibodies (mca) to influenza type a (10f) and b (5h and 6h) viruses have been prepared. by immunoblotting method, mca 10f were found to be specific for np-protein of influenza a virus, and mca 5h and 6h to be specific for hemagglutinin of influenza b virus. it was established that the 10f clone interacted with all the investigated influenza a virus strains with different antigenic formulae (h1n1, h2n2, h3n2) and could be used for typing of this virus type. clones 5h and 6h react spec ... | 1988 | 3064429 |
| influenza subtype-specific iga, igm and igg responses in patients on hemodialysis after influenza vaccination. | the isotype-specific antibody response to influenza vaccination in 36 patients undergoing chronic intermittent hemodialysis was analyzed by an influenza subtype-specific immunofluorescence test. the immune response was recorded at regular intervals over five months. on the basis of fourfold igg titer rises as the classical parameter protection from infection was assumed to occur in more than 85% of healthy adults to each of the influenza antigens. in contrast, about 70% of the patients on hemodi ... | 1988 | 3065242 |
| comparison of tube cultures of madin darby canine kidney cells with shell-vial cultures after low-speed centrifugation for influenza virus isolation. | the efficacy of isolation of influenza viruses was compared in two systems--conventional tube cultures of madin darby canine kidney cells, and shell-vial cultures after low-speed centrifugation. one hundred and fifty eight throat and nasal swabs were inoculated and cultures screened by hemagglutination on days 1, 2, 3 and 5 post-inoculation. twenty-four shell-vial cultures (15.2%) and 6 tube cultures (3.8%) were positive for influenza virus type b, indicating that shell-vial cultures with low-sp ... | 1988 | 3071771 |
| [immunologic analysis of the antigenic properties of neuraminidase from drift-variants of influenza virus b]. | the antigenic features of neuraminidases of several drift variants of influenza b virus were studied by enzyme immunoassay using antiserum to influenza b/ussr/100/83 virus neuraminidase isolated by pronase. studies using immunosorption and competitive solid-phase enzyme immunoassay showed the presence in the antineuraminidase serum of at least two antibody subpopulations capable to inhibiting the activity of the enzyme and interacting with neuraminidase antigenic determinants: one detecting the ... | 1988 | 3073569 |
| viral infections in pediatric bone marrow transplant patients. | the records of 96 pediatric patients with aplastic anemia or a malignancy who underwent bone marrow transplantation between 1979 and 1986 at the children's hospital of philadelphia were reviewed for laboratory evidence of viral infections. the most common viral diseases identified were herpes simplex virus (hsv), cytomegalovirus and adenoviruses, which were found in 19 (20%), 17 (18) and 17 (18) patients, respectively. hsv was more common in patients with than without graft vs. host disease (gvh ... | 1988 | 2830586 |
| selective inhibition of wsn influenza virus haemolysis by pea lectin. | the capacity of lectins to inhibit viral haemolysis of chicken erythrocytes was tested, to evaluate the role of carbohydrate in the fusion reaction. pretreatment of cells with pea lectin provided a 70% to 85% haemolysis inhibition with wsn influenza virus, but only 10% to 14% with pr8 influenza virus. pea lectin did not detectably bind to virus, nor did it inhibit virus binding to cells, but it did inhibit wsn influenza virus elution. additionally, pea lectin was active against sendai virus and ... | 1988 | 2832534 |
| protein synthesis by hepg2 cells infected with influenza b virus. | reye's syndrome is an acute hepatopathy and encephalopathy affecting children during the convalescent period of a viral infection, frequently influenza b. the role of influenza b in the pathogenesis of reye's syndrome is unknown. to investigate this relationship, an in vitro system was designed to examine the interaction of influenza b virus with a cell line of human hepatocytes (hepg2) which retains many specific hepatic synthetic characteristics. hepg2 was capable of supporting a productive in ... | 1988 | 2832818 |
| [immunological characteristics of viral myocarditis]. | a study of cellular and humoral immunity was conducted in patients with viral myocarditis. quantitative and functional deficiency of t-suppressors and an increase in the number of cytotoxic lymphocytes were revealed in most patients. disorder in the t-cellular link of immunity correlated with a clinical course of the disease and was found more frequently in patients with a grave course of myocarditis. | 1988 | 2839908 |
| upper respiratory tract infection and serum antibody responses in nursing home patients. | residents of a veterans administration nursing home care unit (nhcu) were observed for the development of upper respiratory tract infection (uri) during 12 consecutive months to determine the frequency of sporadic cases or outbreaks of uri and to characterize them clinically and by laboratory means. fifty-nine episodes of uri occurred in 56 residents during the study period. serologic testing or virus isolation proved or suggested an etiologic agent on 22 occasions. uri was more common in late f ... | 1988 | 2847597 |
| the presence of both antivirus and antiself antibodies in sera from patients with adenovirus and influenza b. | using the elisa method we examined serum samples from 62 male patients aged 19-23 infected with adenovirus (serotype 7), 22 children aged 7-14 infected with influenza b (b/norway 1/84) and 113 normal subjects aged 5-30. the infections were diagnosed serologically by complement fixation, by inhibition of hemagglutination, by elisa and by viral culture. moreover using enzyme-linked short-time culture assay, the production of specific antivirus antibodies and autoantibodies in vitro by spleen cells ... | 1988 | 2848359 |
| [the results of state trials of inactivated influenza vaccines for children]. | controlled epidemiological surveillance covering the total number of 13,355 schoolchildren aged 11-14 years and adolescents was carried out with a view to compare the efficacies of inactivated influenza vaccines. the children were immunized intradermally in a single injection with inactivated influenza vaccines containing a (h3n2) and a (h1n1) hemagglutinins, 3.5 micrograms per 0.2 ml of the preparation each. the studies demonstrated the safety and low reactogenicity of these vaccines, as well a ... | 1988 | 2968738 |
| two nuclear location signals in the influenza virus ns1 nonstructural protein. | the ns1 protein of influenza a virus has been shown to enter and accumulate in the nuclei of virus-infected cells independently of any other influenza viral protein. therefore, the ns1 protein contains within its polypeptide sequence the information that codes for its nuclear localization. to define the nuclear signal of the ns1 protein, a series of recombinant simian virus 40 vectors that express deletion mutants or fusion proteins was constructed. analysis of the proteins expressed resulted in ... | 1988 | 2969057 |
| the influence of human immunodeficiency virus (hiv) infection on antibody responses to influenza vaccines. | to ascertain whether subjects infected with human immunodeficiency virus (hiv) generally develop protective hemagglutination inhibition antibody responses to inactivated influenza vaccines. | 1988 | 2970238 |
| biological functions of the ns1 protein of an influenza b virus mutant which has a long carboxyl terminal deletion. | to clarify the function of the ns gene of a highly cytolytic mutant of influenza virus b/yamagata/1/73 which expresses an ns1 protein with a long carboxyl terminal deletion (clone 201), we prepared a single gene reassortant (201 l-77) and a control reassortant (yl-20) in which all the genes were of wild type influenza virus b/lee/40 origin except ns gene which was derived from either clone 201 or wild type b/yamagata. comparative studies have revealed that 201 l-77 destructed infected cells more ... | 1988 | 2974275 |
| nebulised ribavirin for influenza b viral pneumonia in a ventilated immunocompromised adult. | 1988 | 2903314 | |
| functional and structural analysis of the ribonucleoprotein complexes of different human influenza virus strains. | ribonucleoprotein (rnp) cores were prepared from various strains of human influenza virus by treating the purified or spikeless virus particles with non-ionic detergents such as nonidet p-40 and centrifugation in continuous linear glycerol gradients. in addition to rna, the purified complexes contained viral nucleoprotein (np) and the three p proteins (pa, pb1, pb2) as determined by polyacrylamide gel electrophoresis (page) under denaturing conditions. contaminations with other viral polypeptide ... | 1988 | 2903632 |
| antibodies to polymerase proteins of influenza virus a/pr/8/34 (h1n1): comparison on the immunoreactivity with polymerase proteins of other influenza a and b virus strains. | the polymerase proteins (pb1, pb2, pa) of the influenza virus strain a/pr/8/34 (h1n1) were isolated from whole virion or ribonucleoprotein (rnp) fractions by electrophoresis on polyacrylamide gel and electroelution or sepharose cl-6b chromatography in the presence of sds. antisera to polymerase proteins (p proteins) were raised in rabbits; the immunoglobulins (ig) were purified by affinity chromatography. characterization of the antibody fraction by western blot analysis showed a highly monospec ... | 1988 | 2903633 |
| interaction between anti-influenza viral polymerase antibodies and rnp particles using the in vitro transcription process and an immunogold labelling technique. | immunogold labelling and in vitro transcription of influenza virus vrna have been used to analyse the interaction of anti-influenza polymerase antibodies with influenza-ribonucleoprotein (rnp) complexes. the polymerase proteins (p proteins) were localized exclusively at one end of the rnp segments. in the course of transcription the amount of p protein decreased significantly. the in vitro transcriptase activity y of influenza a virus rnp complexes in the presence of anti-polymerase antibodies t ... | 1988 | 2904734 |
| effect of mutations and deletions in a bicistronic mrna on the synthesis of influenza b virus nb and na glycoproteins. | the mrna derived from influenza b virus rna segment 6 is functionally bicistronic and encodes the nb and na glycoproteins in different, overlapping reading frames. nb protein synthesis is initiated at the 5'-proximal aug codon, and 4 nucleotides downstream there is a second aug codon which is used to initiate na protein synthesis. the nucleotide sequence context of the first aug codon conforms closely with the established 5'-cc(a/g)ccaugg-3' consensus sequence (m. kozak, nucleic acids res. 15:81 ... | 1989 | 2908923 |
| leads from the mmwr. update: influenza activity--worldwide. | 1989 | 2911154 | |
| [specific and nonspecific indicators of activation of influenza viruses before an epidemic caused by influenza viruses subtype a/h3n2 and type b in czechoslovakia in 1986]. | the authors submit an aetiological and epidemiological analysis of the influenza epidemic which occurred in the csr between the 4th and 14th week of 1986 and was caused by the influenza virus subtype a/h3n2/ and type b. the epidemic affected a total of 27.1% of the population, in the age group of 0-5 years 63.7%, in the age group 6-14 years 52.7% and in the age group above 15 years 17.1%. in the course of the epidemic 77,458 cases of pneumonia and bronchitis were reported and 1,412 deaths with t ... | 1989 | 2920398 |
| leads from the mmwr. influenza vaccine composition recommendation for the 1989-90 season. | 1989 | 2926955 | |
| update: influenza activity--worldwide. | 1989 | 2491764 | |
| update: influenza--united states, 1988-89 season. | 1989 | 2491911 | |
| update: influenza--united states, 1988-89 season. | 1989 | 2492076 | |
| influenza vaccine composition recommendation for the 1989-90 season. | 1989 | 2493570 | |
| acute otitis media and respiratory virus infections. | we studied the association of acute otitis media with different respiratory virus infections in a pediatric department on the basis of epidemics between 1980 and 1985. altogether 4524 cases of acute otitis media were diagnosed. the diagnosis was confirmed by tympanocentesis in 3332 ears. respiratory virus infection was diagnosed during the same period in 989 patients by detecting viral antigen in nasopharyngeal mucus. there was a significant correlation between acute otitis media and respiratory ... | 1989 | 2495520 |
| [immune response to influenza vaccination]. | the present study investigated the level of immunity of the population against three strains of the influenza virus (a chile/1/83 -a philippines/2/82 and b urss/100/83) before and three months after vaccination, and the immune response to whole virus vaccine as compared with fragmented virus vaccine. a high percentage of the population had titers greater than or equal to 1/10 before vaccination for the chile (54%) and philippines (65.7%) strains, while titers against the urss strain were lower ( ... | 1989 | 2518952 |
| comparative study of the immunogenicity of aqueous versus aluminium phosphate adsorbed split influenza vaccine c.i. | the antibody responses induced by the split influenza vaccine adsorbed on aluminium phosphate and the corresponding, nonadsorbed vaccine, both prepared in the cantacuzino institute, were studied in subjects belonging to three different age groups: 3-6, 10-15 and over 60 years of age, respectively. in all age groups the immunogenicity of the two vaccine preparations was similar, being uninfluenced by the level of preexisting antibodies. the immunogenicity of both vaccines was similar even in chil ... | 1989 | 2519636 |
| [influenza b in hospitalized patients in leningrad]. | 1989 | 2525282 |