Publications

rabies-like neuronal inclusions associated with a neoplastic reticulosis in a dog.		1974	4139800
[light microscopic localization of rabies virus antigen by means of peroxidase-labeled immunoglobulin (on the usefulness of immunoenzyme technique)].		1974	4140099
criteria for preparing, evaluating, and standardizing iodinated globulins for radioimmunoassay procedures.	procedures were examined for labeling immune globulins with radioactive iodine using chloramine-t as the oxidizing agent. the chloramine-t method was critically evaluated to establish the optimal conditions for preparing iodinated globulins with high specific radioactivities without impairing their immunospecificities for use in in vitro radioimmunoassays. the results showed that the use of 100 mug of chloramine-t per ml, 500 to 1,000 muci of na (125)i per mg of protein, and a 10-min oxidation r ...	1974	4141599
isolation of viruses from wild mammals in west africa, 1966-1970.		1974	4210769
[antigenicity of a soluble antigen (glycoprotein) of purified rables virus, treated with triton x 100].		1974	4219162
antibody production in milk serum after virus instillation of goat mammary gland vi. "sham infection" with special reference to rabies.	the era strain of rabies vaccine virus failed to propagate or cause clinical manifestations when instilled into the mammary gland of lactating goats. however, the virus did produce neutralizing antibodies in this gland as a result of repetitive viral stimulation, a "sham infection". the protective property of the concentrated and partly purified milk serum antibody was assessed in mice. in the first trial, protective activity was observed when a single dose of milk serum antibody was administere ...	1974	4272951
the importance and histopathology of hypothalamic changes in animals inoculated intracerebrally with högyes' fixed strain of rabies virus.		1974	4219555
characterization of brain-associated rabies neutralizing substance.		1974	4206247
[gamma-aminobutyric acid concentration in the brains of animals infected with fixed rabies virus].		1974	4155823
the diagnosis of rabies in a horse by brain neutralization test.	a horse showing clinical signs of a neurological disorder was killed and various diagnostic tests for rabies were carried out. histopathlogy revealed a nonsuppurative encephalitis. fluorescent antibody test and mouse inoculation test were negative. a positive diagnosis of rabies was based on a high antibody titer (1:10,000) to rabies virus in brain tissue.	1974	4277690
early street rabies virus infection in striated muscle and later progression to the central nervous system.	twelve isolates of street rabies virus were inoculated intramuscularly into young hamsters and the course of infection was followed by frozen section immunofluorescence. animals infected with 10 of the 12 viruses had antigen in striated muscle at day 3, but involvement of other tissues was absent or extremely sparse. muscle infection was still most pronounced at day 6, but neuromuscular spindle, nerve, and brain infections were also detected in a majority of animals. progression of infection was ...	1974	4282379
virus infections in bats.		1974	4367453
rhabdovirus replication in enucleated host cells.	infection of enucleated tc-7 monkey cells with rabies virus resulted in the synthesis of virus-directed rna and the production of rabies antigens but not of infectious virus. the yield of infectious vesicular stomatitis virus from enucleated tc-7 cells, on the other hand, was almost as high as that from intact cells. inhibition of the mitochondrial functions of enucleated cells by treatment with ethidium bromide did not influence the development of rabies antigens or the production of infectious ...	1974	4367906
transcribing complexes in cells infected by vesicular stomatitis virus and rabies virus.	we analyzed cell extracts from bhk(21) cells infected with vesicular stomatitis virus (vsv) and rabies virus for in vitro rna polymerase activity. cells infected with vsv b virions exhibited several complexes with in vitro rna polymerase activity in sucrose gradients. these complexes synthesize vsv transcriptase product (4 to 18s) polyadenylated in rna complementary to virion rna. cells infected with a high multiplicity of b virions and t particles show only one rna polymerase complex active in ...	1974	4369391
inhibitors against rabies virus present in normal rabbit sera.		1974	4370108
persistent noncytocidal vesicular stomatitis virus infections mediated by defective t particles that suppress virion transcriptase.	infectious b virions of vesicular stomatitis virus were 100% lethal to bhk(21) (baby hamster kidney) cells when infecting alone, and persistent noncytocidal infection could not be achieved with cloned b virions alone. however, a mixture of b virions and homologous, short, defective, interfering particles (t particles) of a temperature-sensitive mutant of the virus regularly established persistently infected, noncytocidal carrier cultures. a long t particle was generated during establishment of t ...	1974	4370255
structural phosphoproteins associated with ten rhabdoviruses.		1974	4372298
changes in central nervous system neurons in white mice under the influence of some neurotropic viruses.		1974	4546749
non-fatal rabies in white mice.		1974	4420437
effects of high ambient temperature on various stages of rabies virus infection in mice.	effects of high ambient temperatures on various stages of rabies virus infection have been studied. ambient temperature increased within the tolerated range was found to have little effect upon body temperature of normal mice, but caused marked elevation of temperature during illness. temperatures at onset of patent illness in mice were lower than normal. increased body temperature in the higher thermic ambience during the incubation period was associated with decreased mortality and frequent ab ...	1974	4426698
plasticity of phenotypic characters of rabies-related viruses: spontaneous variation in the plaque morphology, virulence, and temperature-sensitivity characters of serially propagated lagos bat and mokola viruses.		1974	4427078
control of bovine rabies through vampire bat control.		1974	4436917
[electron microscopic study of human acute encephalomyelitis virus].		1974	4446560
[study of rabies virus strains circulating in nature].		1974	4446570
rabies in wild carnivores in central europe. ii. virological and serological examinations.		1974	4446874
a case of rabies with unusual clinical manifestations.		1974	4448515
experimental bovine paralytic rabies--"derriengue".		1974	4450419
[serological relations of the rabies virus with other viruses].		1974	4453940
biological studies and plaquing of mokola virus (rabies serogroup) in porcine kidney (ps) cells.		1974	4465332
[purification and concentration of the rabies virus with polyethylene glycol].		1974	4466044
[rabies in nutria (experimental studies)].		1974	4466052
[extraction of a soluble antigen (a glycoprotein) from rabies tissue culture vaccines using triton x100. immunization and protection experiments (author's transl)].		1974	4468748
detection of homologous rna sequences among six rhabdovirus genomes.	complete transcripts of the genome of vesicular stomatitis virus indiana strain have been used to hybridize to virion rna to determine if there is rna sequence homology among these viruses. cellular rna from cells infected by each of these viruses has also been used for hybridization with the homologous or heterologous virion rna. the results indicate that there is little exact sequence homology among these viruses.	1974	4359427
an interfering component of rabies virus which contains rna.		1974	4360392
pathogenicity of mokola, a rabies-related virus, in baby mice.		1974	4361049
non-specific serum inhibitors of activity of haemagglutinins of rabies and vesicular stomatitis viruses.		1974	4361920
phosphate acceptor amino acid residues in structural proteins of rhabdoviruses.	partial acid hydrolysates of the [(32)p]phosphate- or [(3)h]serine-labeled proteins of purified vesicular stomatitis, rabies, lagos bat, mokola, or spring viremia of carp virions and of purified intracellular nucleocapsids of these viruses have been analyzed by paper electrophoresis for the presence of phosphorylated amino acids. both phosphoserine and phosphothreonine, with the former predominant, were present in virion and nucleocapsid preparations that contained phosphoproteins. an exception ...	1974	4365328
adult and embryonic gecko cells in vitro: growth characteristics, infection by rabies, sindbis and polyoma viruses, and transformation by sv40.		1974	4365679
limitations of deteriorated tissue for rabies diagnosis.		1974	4357492
immunopathologic aspects of infection with lagos bat virus of the rabies serogroup.		1974	4590821
human rabies. diagnosis, complications, and management.		1974	4600621
rabies.		1974	4608103
further studies on the replication of rabies and rabies-like viruses in organized cultures of mammalian neural tissues.	organized cultures of mammalian spinal and dorsal root ganglions were used for a comparative study of the neurocytopathology caused by rabies and so-called rabies-like viruses. electron microscopy and titration of infectivity revised earlier data in which no difference could be demonstrated between street and fixed-virus infection. in the present study, fixed virus produced inclusion bodies without apparent virus assembly. sequential electron microscopy revealed that the main sites of virus asse ...	1974	4608225
[coupled cytoenzymologic and immunofluorescent technic (author's transl)].		1974	4613252
[the rabies virus].		1974	4616382
[prevention of rabies].		1974	4617284
production of rabies fluorescent conjugate by immunization of rabbits with purified rabies antigen.	fluorescein-labelled antirabies virus conjugate was produced by hyperimmunizing rabbits with a purified rabies virus (cvs-27). the conjugate had a working dilution of >/=1: 500 in the rabies fluorescent antibody test. stability under lyophilization was satisfactory.	1974	4619062
[the preparation of rabies virus nucleocapsid specific igg and its purification and conjugation with peroxidase or fluorescein isothiocyanate (author's transl)].		1974	4619766
[1st case of rabies in a bat in poland].		1974	4815534
in vitro stimulation of rabbit lymphocytes after immunization with live and inactivated rabies vaccines.		1974	4825784
proceedings: adaptation of flury hep strain of rabies virus to syrian hamster kidney cell culture.		1974	4828507
proceedings: dynamics of multiplication of flury lep-ch and hep-ch strains of rabies virus adapted to hamster kidney cell (hkc) culture.		1974	4828508
proceedings: adaptation of rabies virus (flury lep strain) to hamster kidney cell culture. preliminary report.		1974	4828509
proceedings: preliminary evaluation of pathogenic and immunogenic properties of the flury lep and hep strains of rabies virus multiplied in chick embryo fibroblasts.		1974	4828510
observations on the pathogenesis of rabies: experimental infection with a virus of coyote origin.		1974	4844503
[experimental infection of the dog with the rabies wild virus strain nyc].		1974	4848722
antibody response to a human diploid cell rabies vaccine.	an experimentally killed rabies virus vaccine prepared in a human diploid cell strain (wi-38)-wyeth rabies vaccine (wrv)-was used by various injection schedules in two separate studies to define more closely in human volunteer subjects an effective vaccination schedule for pre- or postexposure immunization, particularly for donors of rabies-hyperimmune plasma. to permit valid comparisons between our results and those of other workers, antibody levels achieved were expressed in terms of internati ...	1974	4856855
[case of human rabies].		1974	4858881
postexposure rabies prophylaxis with human rabies immune globulin.		1974	4859675
letter: asymptomatic non-fatal canine rabies.		1975	47030
immunogenicity and acceptability of a human diploid-cell culture rabies vaccine in volunteers.	a rabies vaccine, prepared in human diploid-cell culture, was given intradermally (i.d.) or intramuscularly (i.m.) to 35 volumteers who had not previously received prophylactic immunisation. rabies neutralising antibody titres rose sharply after the first dose, and 4 weeks after the second dose all titres were above 1/80 (1-7 i.u. per ml.). immunisation via the i.d. and i.m. routes was equally successful in terms of likely immune status, but the i.d. rate was associated with many more local si ...	1975	47083
letters to the editor: is the negri body specific for rabies?		1975	48371
preservation of stained and unstained tissue impressions for the rabies fluorescent antibody test.		1975	50119
[study of the antigenic relationship of different strains of the rabies group viruses].	in neutralization tests in animals close antigenic relationship between human virus of acute encephalomyelitis (aem) and viruses (297 and 598 sg strains) isolated from wild rodents in czechoslovakia was first established. at the same time, poor antigenic relationship of human aem virus to viruses isolated in africa from bats (lagos bat) and from shrews (yban 27377) was demonstrated. certain differences in the antigenic properties of viruses isolated in africa and in czechoslovakia were found. t ...	1975	54997
[isolation of rabies virus from siberian polecats in kazakhstan].		1975	129961
structure-function relationships and mode of replication of animal rhabdoviruses.	recently accumulated knowledge allows more precise comparison of the structural (and possibly evolutionary) relationships of several different animal rhabdoviruses: vesicular stomatitis virus, rabies virus, kern canyon virus, and spring viremia of carp virus. each virus is composed primarily of a glycoprotein, an rna-associated nucleoprotein, and one or two membrane proteins. vesicular stomatitis virus group viruses contain lesser amounts of two additional distinct polypeptides, ns and l. the se ...	1975	165494
comparative study of the protein kinase associated with animal viruses.		1975	166492
[bovine viruses and methods for their detection].		1975	169627
treatment of wounds from animals suspected of carrying neurotropic viruses.	the methods used at the clinical research centre, northwick park hospital, to treat wounds potentially infected with neurotropic viruses are outlined. emphasis is laid on first aid and on surgical attention. patients should remain under medical supervision for at least four weeks after the injury, the need for specific post-exposure treatment depending on the nature of the exposure.	1975	169950
[sensitivity of various primate cells and animal viruses to the antiviral activity of human leukocyte interferon (author's transl)].	u cells (a permanent, human amnion cell line) were protected against infection with semliki forest virus (sfv) by human interferon (hif) from peripheral leukocytes. despite the usual genus-specific action of interferons, mouse l929 cultures (a permanent mouse fibroblast cell line) were also protected by hif. the antiviral action of hif in six other primate cell cultures was also examined. it is of interest that two lymphoblastoid cell lines, rpmi1788 and kaplan, were insensitive to hif. the sens ...	1975	170886
purification of defective interfering t particles of vesicular stomatitis and rabies viruses generated in vivo in brains of newborn mice.		1975	171834
characterization of rabies viruses recovered from persistently infected bhk cells.		1975	171839
international arbovirus research.	international cooperation in arbovirus research became increasingly prominent shortly after it was found in the early 1940's, that antigenic relationships existed among certain viruses isolated in different areas of thw world. the interest of a number of scientists and of a private organization led to the establishment of an international information exchange and to the preparation of an international catalogue of arboviruses including certain other viruses of vertebrates. international cooperat ...	1975	173936
interferon production by rabies strains isolated from wild rodents.	eight rabies strains isolated from wild rodents produced interferon in laboratory mouse brains the second day after inoculation. low levels of interferon were also detected in the serum, kidneys and lungs of the animals. the dosage and route of inoculation had no pronounced effect on interferon production.	1975	235203
effect of alkaline maintenance medium upon the growth of rabies virus in chick embryo cells.	hep flury strain of rabies virus was propagated in chick embryo cells under maintenance media of different ph. it was found that viral growth was better and reached a markedly higher maximum titer when the initial ph of maintenance medium was 8.2 to 9.0 than when it was 7.4. the enhancement of viral growth was not ascribable to mere neutralization of acids produced from infected cells, because the different media became almost equally neutral within an early phase of growth curve. serial passage ...	1975	238491
plaque assay for rabies serogroup viruses in vero cells.	plaque formation in vero cells has been induced with seven rabies serogroup viruses either cocultivated as infected bhk-21 or aedes albopictus cells, or directly cultivated as infected mouse brain.	1975	809472
[effects of cyclophosphamide on rabies infection in the mouse. protection confered by serotherapy].	a very low pathogenic strain of "fixe" rabies (hep-flury) gives a rise in mortality in mice immunodepressed with cyclophosphamide. in this experiment model, the rabies antiserum gives efficient protection against the virus.	1975	811405
[identification of rabies virus glycoproteins and nucleoproteins in infected cells by specifically labeled immunoglobulins].	the specific nucleoprotein is localized inside the cell in the viral matrix and the immunogenic glycoprotein seems to be present only in the cell membranes.	1975	816505
[demonstration of rabies in a bat in berlin].		1975	1091260
treatment of persons exposed to rabies.	several clinical and epidemiologic criteria have been formulated by the center for disease control in advising physicians on the treatment of persons exposed to possibly rabit animals. when deciding whether or not to institute rabies prophylaxis, the physician must consider (1) the type of exposure, (2) the animal species involved in the exposure and the regional epidemiology of rabies, (3) the circumstances surrounding the exposure, and (4) the treatment alternatives and complications.	1975	1091748
rabies neutralizing antibody determination in tissue culture by direct fluorescent antibody technique.		1975	1092690
pathogenesis of rabies in immunodeficient mice.	the hep and ts2 strains of rabies virus inoculated intracerebrally into adult mice normally cause clinically inapparent infection. in the experiments described, this is converted into a lethal infection by immunosuppression with cyclophosphamide, which also prevented induction of immunity with vaccine. lethal infection of hep-inoculated mice was also observed in mice treated with antihymocytic serum, and in athymic (balb/c-nu) nude mice.	1975	1092760
studies on the oral infectivity of rabies virus in carnivora.	mature and immature red foxes (vulpes vulpes) and striped skunks (mephitis mephitis) were fed varying numbers of white mice infected with street isolates and a fixed strain of rabies virus. rabies deaths and the development of serum neutralizing antibody to rabies virus occurred in both species. the epizootiological implications of these findings are discussed.	1975	1097742
vaccination of foxes against rabies using ingested baits.	a method for immunizing foxes against rabies was evaluated. fifteen of 36 red foxes (vulpes fulva) fed baits impregnated with modified live virus rabies vaccine developed serum rabies neutralizing antibody. the vaccine-bait proved unstable when held at 4 c or 25 c for 96 hours prior to feeding. for safety testing the vaccine virus was administered to opossums (didelphis virginiana), cotton rats (sigmodon hispidus), hamsters (mesocricetus auratus), and chickens (gallus domesticus) in either liqui ...	1975	1097743
sensitivity of bhk-21 cells supplemented with diethylaminoethyl-dextran for detection of street rabies virus in saliva samples.	a tissue culture system for detecting rabies virus from saliva samples of suspected animals was developed and compared to suckling mouse inoculation. swab samples were obtained from the mouth of the animal heads received for rabies diagnosis; these swabs were submerged in maintenance medium. the maintenance medium was inoculated intracerebrally into suckling mice and onto bhk-21 cells with diethylaminoethyl (deae)-dextran (bhk/deae) and without (bhk). rabies immunofluorescence was performed on t ...	1975	1100655
measurement of rabies antibody: comparison of the mouse neutralization test (mnt) with the rapid fluorescent focus inhibition test (rffit).		1975	1102548
[comparative studies on the significance of the "cornea test" in the diagnosis of rabies].	foxes that were positive by the fluorescent antibody test on brain were also positive by the corneal test. the corneal test gave a false-negative results only when the specimen was in a macerated state. out of 133 foxes in which rabies virus was demonstrated in the optic nerve by animal inoculation, only one was negative to the corneal test - this may have been a case of centripetal spread of the infection which was examined at a stage when virus was present in the optic nerve but not in the cor ...	1975	1103770
relationship of two arthropod-borne rhabdoviruses (kotonkan and obodhiang) to the rabies serogroup.	indirect immunofluorescence confirmed the antigenic relationship between kotankan and obodhiang viruses and mokola virus that had originally been shown by complement fixation test. this relationship suggests inclusion of these two arthropod isolates in the rabies subgroup of the rhabdoviridae family. cross-reactivity with mokola virus was also demonstrated by direct immunofluorescence but was easily eliminated when conjugates were diluted. no crossreactivities were found by neutralization tests ...	1975	1104485
[rabies anti-glycoprotein igg conjugated with peroxidase and fluorescein isothiocyanate (author's transl)].		1975	1108733
letter: rabies virus in bts' brain and salivary glands.		1975	1109200
maturation of rabies virus by budding from neuronal cell membrane in suckling mouse brain.	two strains of tissue culture-grown rabies virus developed in suckling mouse brain predominantly by the process of virus budding from the neuronal cell membrane.	1975	1117483
is the negri body specific for rabies? a light and electron microscopical study.	since first described by negri in 1903, the negri body has been regarded as a pathognomonic finding in signifying the presence of rabies encephalitis. negri bodies (light microscope) were found in the brain of a patient with conclusive evidence against the presence of rabies encephalitis. this case provided the opportunity for a pertinent review of the literature in bringing the subject into a reasoned perspective. a definitive etiologic diagnosis of rabies requires the use of electron microscop ...	1975	1122180
determination of the site of oral rabies vaccination.	foxes developed serum neutralizing antibodies to rabies only after oral administration of an attenuated rabies vaccine, and not when a similar vaccine dose was introduced into the stomach. these results emphasize the need for a bait that assures delivery of a vaccine dose orally.	1975	1124754
presence of rabies neutralizing antibodies in wild carnivores following an outbreak of bovine rabies.	in an outbreak of bovine rabies in argentina, a study was made of vampire bats (desmodus rotundus) and wild carnivores. rabies antibody rates of high prevalence were found in the bats, foxes (dusicyon gymnocercus) and skunks (conepatus chinga). the outbreak was part of an extensive continuing epizootic of vampire transmitted bovine rabies which may have also involved other vectors in the area of this study. consumption of dead and dying bats by the carnivores is the suggested means of passage of ...	1975	1142554
[potency testing of inactivated rabies vaccines with the antibody binding test in comparison with the nih and habel test(author's transl)].	the antibody binding test, a new technique for the evaluation of inactivated rabies vaccines, developed by arko, wiktor and sikes, was compared with the nih- and habel test. various vaccines were tested with these methods with the following results and conclusions. 1. the habel test was useful for testing of hempt vaccines. with highly potent vaccines however it was not possible to get exact protection values, for all vaccinated mice were protected against all virus dilutions. 2. the nih test se ...	1975	1154901
therapy of murine rabies after exposure: efficacy of polyriboinosinic-polyribocytidylic acid alone and in combination with three rabies vaccines.	a murine model simulating human street rabies virus infection was used to evaluate the efficacy of polyriboinosinic-polyribocytidylic acid (poly i-poly c), three rabies vaccines, and combinations of these modes of therapy administered after exposure. one or two doses of 100 mug of poly i-poly c, injected into the same intramuscular site as the challenge virus, significantly reduced the mortality rate when therapy was initiated 3 hr after challenge; however, the same quantity of poly i-poly c inj ...	1975	1159327
rabies in experimentally infected bears, ursus spp., with epizootiologic notes.		1975	1166716
structural proteins of two salmonid rhabdoviruses.	purified infectious hematopoietic necrosis (ihn) virus and the virus of haemorrhagic septicaemia (vhs) (egtved virus) each contain five structural proteins which were designated l, g, n, m-1, and m-2. the ihn viral polypeptides have molecular weights estimated to be 157,000, 72,000, 40,000, 25,000 and 20,000, respectively, whereas those of vhs viral polypeptides are estimated to be 157,000 74,000, 41,000, 21,500, and 19,000, respectively. the carbohydrate composition of the glycoprotein (g) was ...	1975	1167914
effect of administered human interferon on experimental rabies in monkeys.	cynomolgus monkeys infected with rabies virus were protected by repeated intramuscular administration of human leukocyte interferon beginning 24 h after infection.	1975	1168171
antibody production in goat milk serum after virus instillation of goat mammary gland. vii. biochemical studies on sham infection with rabies and other non-propagatingagents.	this report describes the development of a method for the production and isolation of neutralizing antibodies against rabies virus (era strain) and other agents in the goat mammary gland during active lactation. the rabies virus did not propagate in thegland, but neutralizing antibodies were produced by serial instillations of the antigen. this process was termed 'sham infection.' antibodies first appeared in the mildabout the 20th day and the titer increased until the 28th day. the antibodies w ...	1975	1168531