Publications

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mechanisms of the protective effects of bmscs promoted by tmdr with heparinized bfgf-incorporated stent in pig model of acute myocardial ischemia.this study investigates the mechanism by which transmyocardial drilling revascularization combined with heparinized basic fibroblast growth factor incorporated degradable stent implantation (tmdrsi) enhanced effects of bone marrow mesenchymal stem cells (bmscs) transplantation against acute ischemic myocardial injury. after the mid-third of left anterior descending artery was ligated, miniswine were divided into none-treatment group (control, n = 6), bmscs implantation group (c, n = 6), tmdrsi g ...201020406325
evaluation of biomechanical and histological features of vertebrae following vertebroplasty using hydroxyapatite blocks.vertebroplasty was performed using hydroxyapatite blocks to examine the course of compressive strength and histological features in a dog model. the vertebral fracture model was prepared by punching a hole in the center of the vertebra and at 4 sites around the vertebra (5 holes in total) from the front side of the vertebra using an air drill and hollowing the holes. measurements were made on healthy vertebrae, vertebrae from the vertebral fracture model, vertebrae removed from animals immediate ...201020192147
status of diurnal primate populations at the former settlement of a displaced village in cameroon.to understand whether or not primate populations recover in areas of abandoned human settlements, data are required that allow for site-specific comparison over time. here, we present baseline information on the presence/absence and relative abundance of primate species at the abandoned settlement of the ekundukundu village, relocated out of the korup national park in 2000. between july 2007 and march 2008, 62 km of transects was surveyed for sightings and calls of primates. all eight species of ...201020198684
randomized controlled trial of high fidelity patient simulators compared to actor patients in a pandemic influenza drill scenario.during disaster drills hospitals traditionally use actor victims. this has been criticized for underestimating true provider resource burden during surges; however, robotic patient simulators may better approximate the challenges of actual patient care. this study quantifies the disparity between the times required to resuscitate simulators and actors during a drill and compares the times required to perform procedures on simulator patients to published values for real patients. a randomized con ...201020398993
comparative efficacy of dermal fibroblast-mediated and direct adenoviral bone morphogenetic protein-2 gene therapy for bone regeneration in an equine rib model.cell-mediated and direct adenoviral (ad) vector gene therapies can induce bone regeneration, including dermal fibroblasts (dfbs). we compared two effective therapies, dfb-mediated and direct ad vector delivery of bone morphogenetic protein-2 (bmp2), for relative efficacy in bone regeneration. equine rib drill defects were treated by percutaneous injection of either dfb-bmp2 or an ad-bmp2 vector. at week 6, both dfb-bmp2- and ad-bmp2-treated rib defects had greater bone filling volume and mineral ...201020220786
recurrent osteoid osteoma: interstitial laser ablation under magnetic resonance imaging guidance.thermal ablation has become a therapy of choice in the treatment of osteoid osteomas. to date, computed tomography has been the standard imaging modality for minimally invasive treatment regimes. we report a case of a 46-year-old man with a recurrent osteoid osteoma in the right tibial head after ct-guided drill excision and repeat treatment with laser ablation under open high-field mri guidance. we describe the steps of the interventional mri procedure and discuss related innovative guidance an ...201020563575
a disaster medicine curriculum for medical students.hospitals are viewed as a haven of safety within a community in the aftermath of a natural or man-made disaster. thus, the importance of disaster training for hospital personnel is paramount. regardless of specialty, all physicians will be called upon to serve. yet, disaster training is not routinely incorporated into the curriculum of undergraduate medical education. the development and implementation of a disaster management course for medical students should therefore be a priority.201020614377
influence of lateral pressure to the implant bed on osseointegration: an experimental study in dogs.to study osseointegration and bone-level changes at implants installed using either a standard or a reduced diameter bur for implant bed preparation.201020626423
overhead drilling: comparing three bases for aligning a drilling jig to vertical.drilling overhead into concrete or metal ceilings is a strenuous task done by construction workers to hang ductwork, piping, and electrical equipment. the task is associated with upper body pain and musculoskeletal disorders. previously, we described a field usability evaluation of a foot lever and inverted drill press intervention devices that were compared to the usual method for overhead drilling. both interventions were rated as inferior to the usual method based on poor setup time and mobil ...201020630276
robotized access to the medullary cavity for intramedullary nailing of the femur.the insertion site for an antegrade femoral intramedullary nail in the treatment of a femoral shaft fracture has traditionally been performed using a free-hand technique. an inappropriate starting point can result in suboptimal nail insertion leading to malreduction, or iatrogenic fracture. furthermore, repeated attempts to establish the optimal starting point can cause additional soft tissue trauma and radiation exposure. in the following study we compared a robot-guided technique with the stan ...201020639594
calvarial bone wound healing: a comparison between carbide and diamond drills, er:yag and femtosecond lasers with or without bmp-7.this study compared the healing of 2 laser ablation units, erbium yag and femtosecond lasers versus conventional mechanical cutting with carbide and diamond drills to explore future applications for bone surgery. the effects of laser or mechanical ablation combined with rhbmp-7 were also investigated.201020656526
preparation and incubation of precision-cut liver and intestinal slices for application in drug metabolism and toxicity studies.precision-cut tissue slices (pcts) are viable ex vivo explants of tissue with a reproducible, well defined thickness. they represent a mini-model of the organ under study and contain all cells of the tissue in their natural environment, leaving intercellular and cell-matrix interactions intact, and are therefore highly appropriate for studying multicellular processes. pcts are mainly used to study the metabolism and toxicity of xenobiotics, but they are suitable for many other purposes. here we ...201020725069
comparison of er:yag laser, piezoelectric, and drill osteotomy for dental implant site preparation: a biomechanical and histological analysis in sheep.the aim of this study was to examine the influence of implant bed preparation, using either er:yag laser ablation, piezoelectric surgery or drill osteotomy, on osseointegration of titanium dental implants after 4, 6, and 8 weeks.201020806390
inlay cranioplasty: an experimental comparison of particulate graft versus bone dust.cranioplasty in children is difficult because autologous bone is limited. to expand the calvarial donor site, surgeons have used bone dust harvested with a power drill and particulate bone taken with a bit and brace. the purpose of this study was to compare bone dust and particulate bone for inlay cranioplasty.201020885252
comparative analysis of multidimensional, quantitative data.when analyzing multidimensional, quantitative data, the comparison of two or more groups of dimensions is a common task. typical sources of such data are experiments in biology, physics or engineering, which are conducted in different configurations and use replicates to ensure statistically significant results. one common way to analyze this data is to filter it using statistical methods and then run clustering algorithms to group similar values. the clustering results can be visualized using h ...201020975140
influence on early osseointegration of dental implants installed with two different drilling protocols: a histomorphometric study in rabbit.to evaluate early osseointegration of dental implants installed with two different drilling protocols.201021039895
scalable multi-variate analytics of seismic and satellite-based observational data.over the past few years, large human populations around the world have been affected by an increase in significant seismic activities. for both conducting basic scientific research and for setting critical government policies, it is crucial to be able to explore and understand seismic and geographical information obtained through all scientific instruments. in this work, we present a visual analytics system that enables explorative visualization of seismic data together with satellite-based obse ...201020975182
deficiency of vitamin a delays bone healing process in association with reduced bmp2 expression after drill-hole injury in mice.although it is predicted that vitamin a and its active form, retinoic acid, regulate osteoblast lineage, this has not been elucidated in growing mammalians. to clarify the direct effect of retinoic acid on bone, we observed the process of filling up newly generating bone into a drill-hole of the bone, which is understood as membranous ossification, in vitamin a-deficient mice. mice were assigned to three groups: a vitamin a-deficient group (vad), which was fed a diet without vitamin a from the 1 ...201020807599
viability of equine embryos after puncture of the capsule and biopsy for preimplantation genetic diagnosis.the equine embryo possesses a capsule that is considered essential for its survival. we assessed viability after breaching the capsule of early (day 6) and expanded (day 7 and 8) equine blastocysts by micromanipulation. the capsule was penetrated using a piezo drill, and trophoblast biopsy samples were obtained for genetic analysis. pregnancy rates for day-6 embryos, which had intact zonae pellucidae at the time of recovery, were 3/3 for those biopsied immediately after recovery and 2/3 for thos ...201020843896
inverted frontal bone and pericraniogaleal flap for frontal sinus hypertrophy.a 31-year-old man with frontal sinus hypertrophy was treated with an inverted frontal bone and pericraniogaleal flap. through a coronal incision and anterior supragaleal dissection, a pericraniogaleal flap was raised down to the supraorbital rim, and the frontal bone was exposed. the protruded anterior wall of the frontal sinus was removed with a drill. the excised piece of bone was inverted and replaced and fixed with microplates. the depressed surface of the inverted bone was made full with a ...201020856065
temporal and spatial modulation of chondrogenic foci in subchondral microdrill holes by chitosan-glycerol phosphate/blood implants.subchondral drilling initiates a cartilage repair response involving formation of chondrogenic foci in the subchondral compartment. the purpose of this study was to structurally characterize these sites of chondrogenesis and to investigate the effects of chitosan-glycerol phosphate (gp)/blood implants on their formation.201021044693
experimental investigations of forces and torque in conventional and ultrasonically-assisted drilling of cortical bone.bone drilling is widely used in orthopaedics and surgery; it is a technically demanding surgical procedure. recent technological improvements in this area are focused on efforts to reduce forces in bone drilling. this study focuses on forces and a torque required for conventional and ultrasonically-assisted tool penetration into fresh bovine cortical bone. drilling tests were performed with two drilling techniques, and the influence of drilling speed, feed rate and parameters of ultrasonic vibra ...201021044856
biological limits of the undersized surgical technique: a study in goats.the purpose of the present study was to investigate the influence of different implant placement techniques on the early bone healing response in an animal model.201021044165
effect of a collateral ligament sparing surgical approach on mechanical properties of equine proximal interphalangeal joint arthrodesis constructs.to (1) compare the effect of a collateral ligament sparing surgical approach with an open surgical approach on mechanical properties of proximal interphalangeal joint (pipj) arthrodesis, and (2) to determine the percentage of articular cartilage surface removed by transarticular (ta) drilling with different diameter drill bits.201021077916
temperature change in pig rib bone during implant site preparation by low-speed drilling.the purpose of this study was to evaluate the temperature change during low-speed drilling using infrared thermography.201021085811
cementation of fiber post: influence of the cement insertion techniques on the bond strength of the fiber post-root dentin and the quality of the cement layer.the aim of this study was to assess the influence of resin cement insertion methods on the bond strength of a fiber post to root dentin and quality of the cement layer.201021217627
mechatronic assistant system for dental drill handling.holding a dental tool for many hours of work is reflected in fatigue and manual tremor, which causes bad handling of rotatory instruments and consequently injuries within the buccal cavity. at present there exists no system to help the medical dentist in the support and handling of the dental drill. we propose the use of a mechatronic system to help the odontologist in handling the dental drill.201021341359
olive leaf extract facilitates healing of experimental cartilaginous injuries in rabbits.we investigated the restorative effect of orally administered olive leaf extract (ole) on experimentally produced cartilaginous injuries in rabbits. in total, three holes in the left stifle joint, including one in the medial trochlear ridge and two in the trochlear sulcus (proximal and distal) of articular cartilage, were prepared surgically using a drill. for the control group only tap water alone was administered daily, and for the ole group a water-based solution of ole (500 mg/kg/day) was ad ...201021182446
[otomyiasis by cochliomyia hominivorax in two children from the outskirts of buenos aires, argentina].cochliomyia hominivorax causes 80% of human myiasis in argentina. nowadays, its geographic distribution covers tropical south america and an important region of argentina. in the present report, two clinical cases of otomyiasis by c. hominivorax in pediatric patients assisted at the hospital de clinicas of buenos aires, argentina are described. the relevance of the taxonomic identification lies in the fact that this species produces severe symptoms owing to the capacity of its larvae to drill th ...201021186671
effect of mineral water from trenčianske teplice (drinkable source, drill sb-3) on lipid peroxidation in vitro.influence of mineral water from trenčianske teplice (drinkable source) on lipid peroxidation processes was determined in model situations under in vitro conditions using the brain tissue. the central nervous system was selected because it is especially sensitive to the radical-induced damage. in addition, there is a high content of polyunsaturated fatty acids in the brain which has a low antioxidant capacity and is relatively rich in iron ions--enhancers of lipid peroxidation processes. we prese ...201021189164
abundance and diversity of biofilms in natural and artificial aquifers of the äspö hard rock laboratory, sweden.six cores were drilled and retrieved from 186-m depth in the äspö hard rock laboratory (hrl) tunnel to investigate whether indigenous biofilms develop on fracture surfaces in groundwater-conducting aquifers in granitic rock. a clone library was constructed from fracture surface material (fsm), for community composition analysis. quantitative polymerase chain reaction (qpcr) was applied to quantify gene copies using the 16s rrna gene for domain bacteria and the adenosine-phosphosulfate reductase ...201021132427
geometric characterization of cell membrane of mouse oocytes for icsi.intracytoplasmic sperm injection (icsi) is a broadly utilized assisted reproductive technology. a number of technologies for this procedure have evolved lately, such as the most commonly utilized piezo-assisted icsi technique (p-icsi). an important problem with this technique, however, is that it requires a small amount of mercury to stabilize the tip of the penetration micropipette. a completely different and mercury-free injection technology, called the rotationally oscillating drill (ros-dril ...201021142316
a comparison of bone bed preparation with laser and conventional drill on the relationship between implant stability quotient (isq) values and implant insertion variables.the aim of this study was to investigate a comparison of implant bone bed preparation with er,cr:ysgg laser and conventional drills on the relationship between implant stability quotient (isq) values and implant insertion variables.201021264194
a computer-assisted instruction course to teach visual-field interpretation.a computer-assisted instruction course for visual-field interpretation is described. a multiple-choice, question-and-answer drill was constructed using the vax/vms minicomputer and commercially available educational software. medical and paramedical personnel can use this course to further their knowledge of visual-field description, the location of lesions which lead to visual-field defects, and the underlying processes that cause some of these defects. the advantages of using a particular comp ...20103044224
canine sacroiliac luxation: anatomic study of the craniocaudal articular surface angulation of the sacrum to define a safe corridor in the dorsal plane for placement of screws used for fixation in lag fashion.to define a safe corridor in the dorsal plane relative to the articular surface for placement of a single screw in lag fashion to achieve stabilization of sacroiliac luxation in the dog. study design: cadaveric study.201021077923
sensitivity analysis of periprosthetic healing to cell migration, growth factor and post-operative gap using a mechanobiological model.a theoretical rationale, which could help in the investigation of mechanobiological factors affecting periprosthetic tissue healing, is still an open problem. we used a parametric sensitivity analysis to extend a theoretical model based on reactive transport and computational cell biology. the numerical experimentation involved the drill hole, the haptotactic and chemotactic migrations, and the initial concentration of an anabolic growth factor. output measure was the mineral fraction in tissue ...201021082458
hospital-based special needs patient decontamination: lessons from the shower.a hospital-based decontamination team tested whether it could (1) perform effective technical decontamination while maintaining safety of staff and patients; (2) safely accommodate unique needs in the showers, including guide dogs and motorized wheelchairs; (3) identify needs of special needs populations by patient type, including blindness, hearing loss, and cognitive learning disabilities; (4) outline effective use of federal preparedness funds to support planning and execution of tabletop and ...201021319553
[study on the change of dune co2 concentration in the autumn at minqin in tengger desert].in order to find out the co2 concentration of the desert area, the influence of it on the co2 in the atmosphere and the role that it played on the global carbon cycle, the research team utilized in september 2009 infrared co2 monitor to observe the co2 concentration of the 12 drill holes day and night in minqin desert area in the tengger desert. the difference of various observation spots' co2 concentration of the desert area in the tengger desert area is relatively big. the co2 concentration at ...201021360892
a precision alignment frame for endosseous post dental implants.the advantages of the precision alignment frame are that it (1) accurately positions and aligns the initial pilot drill at implant surgery, (2) has no adverse effects on the diagnostic cast, (3) eliminates the need for an incision or raising a flap when locating a submerged implant root for transmucosal connection, (4) consistently and accurately records the relation of the implant root to the radiograph, (5) permits long-term evaluation of the implant after restoration, (6) has components that ...20103058942
bone sialoprotein, but not osteopontin, deficiency impairs the mineralization of regenerating bone during cortical defect healing.bone healing is a complex multi-step process, which depends on the position and size of the lesion, and on the mechanical stability of the wounded area. to address more specifically the mechanisms involved in cortical bone healing, we created drill-hole defects in the cortex of mouse femur, a lesion that triggers intramembranous repair, and compared the roles of bone sialoprotein (bsp) and osteopontin (opn), two proteins of the extracellular matrix, in the repair process. bone regeneration was a ...201019761880
use of a piezo drill for intracytoplasmic sperm injection into cattle oocytes activated with ionomycin associated with roscovitine.intracytoplasmic sperm injection (icsi) consists of the introduction, by micromanipulation, of a single sperm into the cytoplasm of a mature egg. this technique is particularly advantageous when only a few sperm are available for fertilization, representing an important tool in preserving genetic material, especially from poorly fertile males. the results from icsi in cattle are very often unsatisfactory and difficult to reproduce. thus, the goal of this study was to evaluate the effect of the u ...201019144028
er:yag laser ablation of bone in experimental diabetics.the aim of this study was to compare bone healing in experimental diabetics after ostectomies obtained by er:yag laser and bur drilling. study design/material and methods: twenty-eight wistar rats weighing 250-300 g were used for this study. diabetes was chemically induced with streptozotocin administered as a single intraperitoneal injection. fourteen nondiabetic (normal) and 14 diabetic rats were included in the analysis. left femur distal epiphysis of nondiabetic and diabetic rats was perfora ...201019795995
a comparison of the thermal properties of 2- and 3-fluted drills and the effects on bone cell viability and screw pull-out strength in an ovine model.drilling of bone is associated with an increase in temperature of the surrounding bone which may result in osteonecrosis.201020359798
interactive bone drilling using a 2d pointing device to support microendoscopic discectomy planning.to support preoperative planning of bone drilling for microendoscopic discectomy, we present a set of interactive bone-drilling methods using a general 2d pointing device.201020364410
accuracy of a laboratory-based computer implant guiding system.computer-guided implant placement is a growing treatment modality in partially and totally edentulous patients, though data about the accuracy of some systems for computer-guided surgery is limited. the purpose of this study was to evaluate the accuracy of a laboratory computer-guided system.201020416521
automatic identification of otological drilling faults: an intelligent recognition algorithm.this article presents an intelligent recognition algorithm that can recognize milling states of the otological drill by fusing multi-sensor information.201020506443
development and in situ application of an adjustable aiming device to guide extra- to intraarticular tibial tunnel drilling for the insertion of the cranial cruciate ligament in dogs.to develop and test an arthroscopic aiming device for extra- to intraarticular tibial tunnel drilling emerging at the center of the tibial insertion (centertib) of the cranial cruciate ligament (ccl) in medium to large breed dogs.201020522212
scaffold-guided subchondral bone repair: implication of neutrophils and alternatively activated arginase-1+ macrophages.microfracture and drilling elicit a cartilage repair whose quality depends on subchondral bone repair. alternatively activated (aa) macrophages express arginase-1, release angiogenic factors, and could be potential mediators of trabecular bone repair.201020522834
effects of attachment sites and joint angle at the time of lateral suture fixation on tension in the suture for stabilization of the cranial cruciate ligament deficient stifle in dogs.to investigate the influence of different sites of lateral suture fixation for stabilization of the cranial cruciate ligament (ccl) deficient stifle and different joint angles at time of tightening on suture tension.201020522213
use of carboxymethyl cellulose and collagen carrier with equine bone lyophilisate suggests late onset bone regenerative effect in a humerus drill defect - a pilot study in six sheep.we assessed the use of a filler compound together with the osteoinductive demineralized bone matrix (dbm), colloss e. the filler was comprised of carboxymethyl-cellulose and collagen type 1. the purpose of the study was to see if the filler compound would enhance the bone formation and distribute the osteoinductive stimulus throughout the bone defect. six sheep underwent a bilateral humerus drill defect. the drill hole was filled with a compound consisting of 100 mg cmc, 100 mg collagen powder, ...201020582241
effect of implant drill design on the particle size of the bone collected during osteotomy.the bone particles collected during osteotomy could be used as autogenous bone graft materials for implant placement surgery. this study examined the effect of drill design on the quantity and size of bone collected during the preparation of implant sites. bone was collected during the in vitro preparation of bovine bone using three different implant system drills: parallel shape (group 1), tapered shape (group 2), and tapered and stepped shape (group 3). bone particles were sieved. the wet volu ...201020566268
enhancing oral implantology with power ultrasonics.oral implantology is the branch of dentistry focused on the reconstruction of missing teeth and their supporting structures with natural or synthetic substitutes. conventional instruments used during oral implantation exhibit severe operational limitations, especially in the presence of limited surgical access, anatomically delicate bone structures, and proximity to soft tissues, because of the high risk of injury. this paper illustrates the design and performance characteristics of two novel ul ...201020875983
[the influence of chemically-modified sla on bone defect healing around implants in dogs].the study was designed to investigate the effect of surface chemical modification on the process of bone defect healing around implants in dogs.201020635045
drilling through impacted ureteral stones: use of the atherectomy rotablator device for urolithiasis.the rotablator is an angioplasty device that is passed over a wire. it uses a high-speed rotational "burr" (2 mm in diameter) that is coated with microscopic diamond particles and cooled by saline. it rotates at high speed (approximately 200,000 rpm) breaking up endovascular blockage into minute (smaller than red blood cells) fragments. we investigated, in vitro and ex vivo, the possible use of the rotablator for urinary stone disease.201020575684
osteotomy irrigation: is it necessary?surgical placement of dental implants requires an osteotomy. there is suspicion that osseous drilling may generate detrimental heat in the site that may cause localized bone necrosis and, subsequently, failure of the dental implant to osseointegrate. cooling aqueous irrigation has been advocated to prevent such overheating. however, irrigation can interfere with operator vision and precludes bone shaving collection from the drill flukes for use in autogenous grafting. small diameter drills may g ...201020523180
use of fibrin glue for open comminuted nasal bone fractures.nasal bone fractures are the most common type of facial fracture. closed reduction has been used as the standard treatment modality for nasal fractures for many years. in cases of nasal fracture with lacerations at the fracture sites, bioabsorbable/metallic plate or interfragment wire fixation can be used with accurate alignment through the openings created by the lacerations. however, in cases of severe comminuted nasal fractures that are difficult to drill and fix, this type of fixation may no ...201020061971
protection of tympanomeatal flaps using visibility background material.over the years, various materials have been used by otologists to protect tympanomeatal flaps from damage by suction equipment or drills.201020370951
field evaluation of a modified intervention for overhead drilling.drilling holes into concrete or metal ceilings is one of the most physically demanding tasks performed in construction. the work is done overhead with rotary impact hammer drills that weigh up to 40 n. the task is associated with pain and musculoskeletal disorders at the wrist, forearm, shoulder, and back. the mechanism of injury is thought to be the high forces and non-neutral shoulder and wrist postures applied during drilling. previously, we described a field study of a foot lever and inverte ...201020094939
surgical induction of endolymphatic hydrops by obliteration of the endolymphatic duct.surgical induction of endolymphatic hydrops (elh) in the guinea pig by obliteration and obstruction of the endolymphatic duct is a well-accepted animal model of the condition and an important correlate for human meniere's disease. in 1965, robert kimura and harold schuknecht first described an intradural approach for obstruction of the endolymphatic duct (kimura 1965). although effective, this technique, which requires penetration of the brain's protective covering, incurred an undesirable level ...201020098359
biomechanical properties of orthodontic miniscrews. an in-vitro study.comparing five commercially-available miniscrew types for skeletal anchorage with regard to the biomechanical properties influencing their primary stability.201020135250
self-drilling and self-tapping screws: an ultrastructural study.the aim of the current study was to compare self-drilling and self-tapping screws with regard to bone contact and the production of bone debris using scanning electron microscopy.201020216445
the influence of erbium:yttrium-aluminum-garnet laser ablation with variable pulse width on morphology and microleakage of composite restorations.the objective of this study was to evaluate the influence of various pulse widths with different energy parameters of erbium:yttrium-aluminum-garnet (er:yag) laser (2.94 mum) on the morphology and microleakage of cavities restored with composite resin. identically sized class v cavities were prepared on the buccal surfaces of 54 bovine teeth by high-speed drill (n = 6, control, group 1) and prepared by er:yag laser (fidelis 320a, fotona, slovenia) with irradiation parameters of 350 mj/ 4 hz or 4 ...201019802717
effect of biostimulation on healing of bone defects in diabetic rats.the aim of this study was to investigate the effects of biostimulation on healing of bone defects in diabetic rats. study design/material and methods: twenty-eight wistar rats weighting 250 to 300 g were used for this study. diabetes was chemically induced with streptozotocin, and 14 nondiabetic and 14 diabetic rats were included in the study. the distal epiphysis of the right and left femurs of the diabetic rats were perforated with a surgical bone drill. this surgical procedure was performed o ...201019860570
health status of anthracite surface coal miners.in 1984-1985, medical examinations consisting of a chest radiograph, spirometry test, and questionnaire on work history, respiratory symptoms, and smoking history were administered to 1,061 white males who were employed at 31 coal cleaning plants and strip coal mines in the anthracite coal region of northeastern pennsylvania. the prevalence of radiographic evidence of international labour office (ilo) category 1 or higher small opacities was 4.5% in 516 men who had never been employed in a dusty ...20102930249
what's unusual in online disease outbreak news?accurate and timely detection of public health events of international concern is necessary to help support risk assessment and response and save lives. novel event-based methods that use the world wide web as a signal source offer potential to extend health surveillance into areas where traditional indicator networks are lacking. in this paper we address the issue of systematically evaluating online health news to support automatic alerting using daily disease-country counts text mined from rea ...201020618980
virtual reality triage training provides a viable solution for disaster-preparedness.the objective of this study was to compare the relative impact of two simulation-based methods for training emergency medicine (em) residents in disaster triage using the simple triage and rapid treatment (start) algorithm, full-immersion virtual reality (vr), and standardized patient (sp) drill. specifically, are there differences between the triage performances and posttest results of the two groups, and do both methods differentiate between learners of variable experience levels?201020670325
effects of non-aqueous fluids-associated drill cuttings discharge on shelf break macrobenthic communities in the campos basin, brazil.this paper assesses the effects of non-aqueous fluids (naf)-associated drill cuttings discharge on shelf break macrobenthic communities in the campos basin, off the southeast brazilian coast, rio de janeiro state. samples were taken with a 0.25-m2 box corer from surrounding two oil and gas wells on three monitoring cruises: before drilling, three months after drilling, and 22 months after drilling. statistical methodologies used bayesian geostatistical and analysis of variance models to evaluate ...201020524059
induced pluripotent stem cells from highly endangered species.for some highly endangered species there are too few reproductively capable animals to maintain adequate genetic diversity, and extraordinary measures are necessary to prevent extinction. we report generation of induced pluripotent stem cells (ipscs) from two endangered species: a primate, the drill, mandrillus leucophaeus and the nearly extinct northern white rhinoceros, ceratotherium simum cottoni. ipscs may eventually facilitate reintroduction of genetic material into breeding populations.201121892153
[unusual migration of a kirschner wire following drill wire fixation of a subcapital humerus fracture]. 20113326601
sowing simulation tests of a pneumatic drill equipped with systems aimed at reducing the emission of abrasion dust from maize dressed seed.the utilization of dressed seed for spring sowing is a widespread practice to control some pests with reduced doses of chemical products. however some insecticides employed in maize seed dressing, namely belonging to the neonicotinoid family and fipronil, have been claimed to play a role in the decline of honeybees (apis mellifera l.). pneumatic drills used in maize sowing are charged with contributing to the dispersion of the abrasion dust produced by dressed seeds, favoring the contamination o ...201121726139
preliminary study on persistence in soil and residues in maize of imidacloprid.the aim of this work was to study the distribution of imidacloprid in soil and its translocation to roots and aerial parts of maize plant. the main objective was to assess imidacloprid residues in field environment, in order to provide data on honeybees exposure level to such an active substance. imidacloprid has been detected and quantified by triple quadrupole hplc-ms-ms. pesticide persistence in the soil and its residues in pollen and in maize plants have been evaluated during the growing of ...201121726143
platelet derived growth factor secretion and bone healing after er:yag laser bone irradiation.er:yag laser irradiation has been reported to enhance wound healing. however, no studies have evaluated the synthesis of growth factors after laser irradiation. the present study investigated the effects of laser irradiation on the amount of secretion of platelet derived growth factor (pdgf) in the wound, clarifying the effects of the er:yag laser on the bone healing. osteotomies were prepared in the tibiae of 28 rats using an er:yag laser (test group). maximum power of 8 watts, energy per pulse ...201120594059
tissue-engineered constructs based on spcl scaffolds cultured with goat marrow cells: functionality in femoral defects.this study aims to assess the in vivo performance of cell-scaffold constructs composed of goat marrow stromal cells (gbmcs) and spcl (a blend of starch with polycaprolactone) fibre mesh scaffolds at different stages of development, using an autologous model. gbmcs from iliac crests were seeded onto spcl scaffolds and in vitro cultured for 1 and 7 days in osteogenic medium. after 1 and 7 days, the constructs were characterized for proliferation and initial osteoblastic expression by alkaline phos ...201120603869
Microdrilled Cartilage Defects Treated with Thrombin-Solidified Chitosan/Blood Implant Regenerate a More Hyaline, Stable, and Structurally Integrated Osteochondral Unit Compared to Drilled Controls.This study analyzed the long-term cartilage and subchondral bone repair of microdrilled defects treated with chitosan glycerol-phosphate/blood implant, using thrombin (Factor IIa) to accelerate in situ solidification. We also evaluated the cartilage repair response to six smaller microdrill holes compared with two larger holes. Bilateral knee trochlear cartilage defects were created in n=8 skeletally mature rabbits, drilled with six proximal 0.5?mm and two distal 0.9?mm holes, then covered with ...201121942869
the use of cone-beam computed tomography and digital periapical radiographs to diagnose root perforations.the aim of this study was to compare the sensitivity and specificity of cone-beam computed tomography (cbct) scans and digital periapical radiographs (pr) in detecting strip and root perforations after root canal treatment in mandibular molars.201121419300
rupture length of the sinus membrane after 1.2 mm puncture and surgical sinus elevation: an experimental animal cadaver study.objectives.: to evaluate the rupture length of the sinus membrane after applying a defined 1.2 mm defect comparing 3 different techniques: summers lift, balloon-assisted technique (basl), and hydrodynamic ultrasonic cavitational sinus lift (hucsl). study design.: thirty fresh sheep heads (60 maxillary sinuses) were investigated. the sinus membrane was ruptured using a 1.2 mm pilot drill. then summers lift, basl, and hucsl were each performed on 20 sinuses, creating a 5 mm vertical lift of the si ...201121330165
piezoelectric driven non-toxic injector for automated cell manipulation.stimulated by state-of-the-art robotic and computer technology, intra cytoplasmic sperm injection (icsi) automation aims to scale and seamlessly transfer the human hand movements into more precise and fast movements of the micro manipulator. piezo-drill cell injection, a novel technique using piezo-driven pipettes with a very small mercury column, has significantly improves the survival rates of icsi process. it is found that complications are due, in large part, to toxicity of mercury and the d ...201121335794
effects of cochlear drilling with piezosurgery medical device in rats.drilling on the otic capsule for cochleostomy should be less traumatic to the cochlea with the piezosurgery medical device (pz) than with a standard diamond drill (dd). "soft" cochleostomy is used for preservation of residual hearing in cochlear implant patients. pz drilling can be used for accurate cochleostomy placement with minimal soft-tissue damage and may be superior for atraumatic drilling on the cochlea, as compared with a dd. this study compared inner ear effects after drilling the rat ...201121154673
Remediation of oil-based drill cuttings through a biosurfactant-based washing followed by a biodegradation treatment.In this study, oil-based drill cuttings were washed by a rhamnolipid solution and then subjected to bioremediation in stainless steel boxes using sawdust as bulking agent. A mixed bacterial culture, mainly containing Pseudomonas, Acinetobacter, Alcaligenes, Agrobacterium, and Comamonas, was used as inoculums. Approximately 83% of organics were removed after washing under optimal conditions (liquid/solid ratio, 3:1; washing time, 20 min; stirring speed, 200 rpm; rhamnolipid concentration, 360 mg/ ...201121925873
osteogenic potential of autogenous bone grafts harvested with four different surgical techniques.the osteogenic potential of autogenous bone grafts is superior to that of allografts and xenografts because of their ability to release osteoinductive growth factors and provide a natural osteoconductive surface for cell attachment and growth. in this in vitro study, autogenous bone particles were harvested by four commonly used techniques and compared for their ability to promote an osteogenic response. primary osteoblasts were isolated and seeded on autogenous bone grafts prepared from the man ...201121940523
accuracy of a cone beam computed tomography-guided surgical stent for orthodontic mini-implant placement.abstract objective: to validate the accuracy of a cone-beam computed tomography (cbct)-guided surgical stent for orthodontic mini-implant (omi) placement by quantitatively evaluating the difference between cbct-prescribed and actual position of mini-implants in preoperative and postoperative cbct images. materials and methods: a surgical stent was fabricated using teflon-perfluoroalkoxy, which has appropriate biological x-ray attenuation properties. polyvinylsiloxane impression material was used ...201121875317
proteinase-activated receptor-2 is required for normal osteoblast and osteoclast differentiation during skeletal growth and repair.proteinase-activated receptor-2 (par(2)) is a g-protein coupled receptor expressed by osteoblasts and monocytes. par(2) is activated by a number of proteinases including coagulation factors and proteinases released by inflammatory cells. the aim of the current study was to investigate the role of par(2) in skeletal growth and repair using wild type (wt) and par(2) knockout (ko) mice. micro computed tomography and histomorphometry were used to examine the structure of tibias isolated from uninjur ...201122173052
a pilot comparison of laser-assisted vs piezo drill icsi for the in vitro production of horse embryos.intracytoplasmic sperm injection (icsi) is the method of choice for the in vitro production (ivp) of equine embryos. however, conventional icsi has been associated with mechanical damage to the oocyte caused by the deformation of the zona pellucida (zp) and exposure of the oolemma to negative pressure during injection. introduction of the less traumatic and more efficient piezo drill-assisted icsi (pdai) yielded higher cleavage rates and more consistent results. nevertheless, pdai is also associ ...201121950451
tai chi () pedicle screw placement for severe scoliosis.study design:: retrospective. objective:: to evaluate the clinical safety and accuracy of the tai chi () technique for placing pedicle screws, without intraoperative radiographic imaging, in severe scoliotic spines. summary of background data:: the current techniques for pedicle screw placement have a number of drawbacks in cases of severe scoliosis, including difficulty or impossibility to use, delayed operative time, requiring the presence of trained personnel for the duration of the surgery, ...201122124422
microcomputed tomographic analysis of bone reaction at insertion of orthodontic mini-implants in sheep.to evaluate the effects on bone of forced insertion of self-tapping orthodontic mini-implants and thus obtain biomechanical data to develop insertion protocols and optimize drills for implant site preparation.201122167428
Histomorphometric analysis of the repair process of autogenous bone grafts fixed at rat calvaria with cyanoacrylate.The purpose of this study was to perform histological and histometric analyses of the repair process of autogenous bone grafts fixed at rat calvaria with ethyl-cyanoacrylate adhesive.201121986659
skin protection during external fixation frame pin insertion: an alternative method.local skin necrosis and pin tract infections are common sequelae following the application of external fixation skeletal frames. drill guides are effective instruments that help to minimize these problems. standard nasal speculums are readily available in most operating rooms and can also be used to protect skin and soft tissues during pin insertion.20113199471
Early partial monolateral zygomatic arch defect leads to unilateral craniofacial malformation.This study used reconstructed three-dimensional imaging to examine the influence of early partial monolateral zygomatic arch defect on the craniofacial development in a minipig model.201121959455
designing a custom made gauge device for application in the access hole correction in the dental implant surgical guide.anatomic limitation and restorative demands encourage the surgeon to gain precision in planning and surgical positioning of dental implants. ideal placement facilitates the establishment of favorable forces on the implants and the prosthetic component as well as ensures an esthetic outcome. the predictability of success can be increased, if the implants are placed properly. during oral implant placement, the drill must be guided by the surgeon according to the final form of the restoration. a su ...201123858287
Face and Content Validation of a Virtual Reality Temporal Bone Simulator.Objective. To validate the VOXEL-MAN TempoSurg simulator for temporal bone dissection.Study Design. Prospective international study.Setting. Otolaryngology departments of 2 academic health care institutions in the United Kingdom and United States.Subjects and Methods. Eighty-five subjects were recruited consisting of an experienced and referent group. Participants performed a standardized familiarization session and temporal bone dissection task. Realism, training effectiveness, and global impre ...201122051543
Nerve damage assessment following implant placement in human cadaver jaws - an ex vivo comparative study.Abstract The present study compared the use of Cone Beam Computerized Tomography (CBCT) images and intraoral radiographs in the placement of final implant drills in terms of nerve damage to cadaver mandibles. Twelve cadaver hemimandibles obtained from 6 cadavers were used. Right hemimandibles were imaged using periapical radiography and left hemimandibles using CBCT, and the images obtained were used in treatment planning for the placement of implant drills (22 for each modality, for a total o ...201122150347
gastrointestinal parasites of captive and free-roaming primates at the afi mountain primate conservation area in calabar, nigeria and their zoonotic implications.a study on the gastrointestinal parasites among free-living and captive primates at the afi mountain, primate conservation area in calabar, nigeria was undertaken for the first time to ascertain their zoonotic implications. faecal samples were subjected to direct smear, floatation, quantitative estimation of helminth eggs (epg) and oocysts (opg), larval isolation and identification by modified baerman's technique and oocyst sporulation for specie identification. out of the 108 primates examined, ...201122308652
relief of lumbar canal stenosis using multilevel subarticular fenestrations as an alternative to wide laminectomy: preliminary report.we describe an operative approach to lumbar canal stenosis which, unlike laminectomy, takes into account the segmental pathology of the disease. at each level involved, a bilateral subarticular fenestration is performed under high magnification. the medial third of each facet joint is first removed with an air-powered drill; then the remaining two-thirds of the joint is undercut with the drill to allow a generous fenestration in the thickened ligamentum flavum and adjacent laminae. all tissue re ...20113200393
a comparitive clinical study between self tapping and drill free screws as a source of rigid orthodontic anchorage.self-tapping miniscrews are commonly being used as a temporary anchorage device for orthodontic purpose. a prerequisite for the insertion of these screws is the preparation of a pilot hole, which is time consuming and may result in damage to nerves, tooth root, drill bit breakage and thermal necrosis of bone. on the other hand the design of drill-free screws enables them to be inserted without drilling. the aim of this prospective study was to compare the stability and clinical response of the s ...201123449815
craniotomy: true sham for traumatic brain injury, or a sham of a sham?abstract neurological dysfunction after traumatic brain injury (tbi) is caused by both the primary injury and a secondary cascade of biochemical and metabolic events. since tbi can be caused by a variety of mechanisms, numerous models have been developed to facilitate its study. the most prevalent models are controlled cortical impact and fluid percussion injury. both typically use "sham" (craniotomy alone) animals as controls. however, the sham operation is objectively damaging, and we hypothes ...201121190398
impaired bone healing pattern in mice with ovariectomy-induced osteoporosis: a drill-hole defect model.to establish a drill-hole defect model in osteoporotic mouse femur by comparing temporal cortical bone healing pattern between ovx-induced osteoporotic bone and sham-operated bone.201121421090
[acoustic-mechanical trauma during cochleostomy: animal experimental studies].when performing cochlear implant (ci) surgery in ears with residual hearing, cochlear function should be preserved as far as possible. besides non-traumatic electrode insertion the acoustic-mechanical trauma of the cochleostomy should be minimized. according to experiences from temporal bone preparations the hypothesis that thorough exposition of the endosteal membrane with the drill prior to opening the cochlea might constitute a bigger acoustic mechanical trauma than direct drilling of the inn ...201121424134
microdialysis in the femoral head of the minipig and in a blood cloth of human blood.microdialysis can detect ischemia in soft tissue. in a previous study, we have shown the development of ischemia in the femoral head removed from patients undergoing total hip replacement. that study also raised some methodological questions that this study tries to answer: what is happening in the dead space around the catheter in the drill canal, and is there an equilibrium period after the insertion of the catheter?201121428845
surgical preparation of bone-scaffold interface is critical for bone regeneration inside tissue engineering scaffold.the goal of this study was to investigate if the preparation of implantation site affects bone formation inside tissue engineering scaffolds. for this purpose, two different drilling techniques were used to create a hole in distal femurs of rats before the insertion of a bone scaffold: a manually driven wood drill bit and an electrically driven metal drill bit. the size and the position of the hole were identical for the two cases. the bone volume, bone mineral density, and callus formation were ...201121437957
onlay and inlay bone grafts with platelet-rich plasma: histologic evaluations from human biopsies.the aim of the present study was to histomorphometrically evaluate biopsies from 1) sinus inlay bone grafts prepared with or without platelet-rich plasma (prp) and 2) onlay bone grafts in the anterior maxilla with particulate bone and prp or block bone without prp after 3 months.201121440827
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