Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| pharmacokinetics of isosorbide dinitrate in rhesus monkey, cynomolgus monkey, and baboon. | at 2 min after intravenous injection of isosorbide dinitrate (1 mg/kg), mean plasma drug concentrations were 565 +/- 66 (sd), 586 +/- 43, and 1572 +/- 253 ng/ml in the rhesus monkey, cynomolgus monkey, and baboon, respectively. following a relatively short distribution phase, mean plasma concentrations declined with half-lives of 62, 23, and 24 min in these three species, respectively. the time course of plasma concentrations could be described by a two-compartment open model, although a one-com ... | 1981 | 7299675 |
| hyperprolactinemia in monkeys: induction by an estrogen-progesterone synergy. | to evaluate the synergistic effect of estrogens and progesterone on prolactin secretion, rhesus and cynomolgus monkeys in the early follicular phase received estradiol benzoate (100 microgram/kg/day, sc) alone for 14 days, then in combination with progesterone (subcutaneous silastic capsule) for an additional 14 days. blood was drawn daily by femoral venipuncture under ketamine hydrochloride anesthesia (15 mg/kg). similarly, this protocol for exogenous steroid treatment was employed in a monkey ... | 1981 | 7303037 |
| effect of ascorbic acid on copper and cholesterol in adult cynomolgus monkeys fed a diet marginal in copper. | the effects of prolonged consumption of high levels of dietary ascorbic acid on copper metabolism and cholesterol in adult monkeys fed a diet low or marginal in copper were investigated. small reductions in serum copper and in serum ceruloplasmin levels were observed when high levels of ascorbic acid were fed. during the period of copper depletion there was a gradual but significant (p less than 0.001) increase in serum cholesterol. the level of ascorbic acid supplementation had no effect during ... | 1981 | 7304479 |
| rapid in vivo metabolism of leukotriene c3 in the monkey macaca irus. | 1981 | 7306127 | |
| ocular biometry of the cynomolgus monkey. | eight cynomolgus monkeys underwent ocular biometry. body weight = 3.04 +/- 0.59 kg; horizontal corneal diameter = 9.79 +/- 0.47 mm; anterior corneal curvature = 59.20 +/- 1.51 diopters at 90 degrees, 58.81 +/- 2.18 diopters at 180 degrees, 0.40 +/- 1.03 diopters at 90 degrees-180 degrees; anterior chamber depth = 2.79 +/- 0.27 mm; lens thickness = 3.18 +/- 0.15 mm; vitreous cavity length = 11.25 +/- 0.51 mm; total internal axial length = 17.16 +/- 0.69 mm. most of the ocular parameters were corr ... | 1981 | 7307539 |
| serological survey for sv5, measles and herpes simplex infections in newly-imported cynomolgus monkeys. | on 592 cynomolgus monkeys of newly-imported 14 different groups, sero-epidemiological follow-up surveys of natural infections with sv5, measles (mv) and herpes simplex (hsv) were conducted both at the time of arrival and at the end of the 9-week quarantine period at tsukuba primate center for medical science (tpc). at the time of arrival, the positive rate of antibodies against these viruses greatly varied with different countries of origin. as regards sv5, the positive rate ranged widely from 0 ... | 1981 | 7311109 |
| a comparative study of the respiratory responses to bronchoactive agents in rhesus and cynomolgus monkeys. | respiratory responses to a variety of known bronchoactive agents were compared in anesthetized rhesus (macaca mulatta) and cynomolgus (macaca fascicularis) monkeys. administration of 0.1 to 1.0% histamine aerosols resulted in an increase in airway resistance of 50 to 200% and a decrease in lung compliance of 30 to 80%. aerosols of prostaglandin e2 (1 mg/ml), terbutaline (10 mg/ml), and isoproterenol (10 mg/ml) or iv aminophylline (up to 7.0 mg/kg) administered concomitantly with histamine produc ... | 1981 | 7311565 |
| cyclic amplitude, variations of a slow erg off-effect, the h-wave, in the cynomolgus monkey. | 1981 | 7314494 | |
| anaphylactic shock in monkeys passively sensitized with human reaginic serum. i. hemodynamics and cardiac performance. | mechanisms inducing a low cardiac output (co) state in ige-mediated (cytotropic) anaphylactic shock in anesthetized macaca irus monkeys were studied. 7 monkeys were sensitized by 2 i.v. injections of a human reaginic serum containing a high concentration of ige antibodies against dog albumin. anaphylactic shock was elicited 48 h after the last sensitization dose, by an i.v. injection of dog albumin. the severe anaphylactic shock which developed was characterized by an initial phase consisting of ... | 1981 | 7315393 |
| [two cases of natural infection of angiostrongylus cantonensis in cynomolgus monkeys (macaca fascicularis) (author's transl)]. | two of 80 cynomolgus monkeys, macaca fascicularis, imported from indonesia showed weakness, anorexia, paralysis of extremities and dysstasia. the blood test conducted at the time of autopsy proved that the white blood cell count markedly decreased in both cases and the blood urea nitrogen content increased in case no. 1. in case no. 2, a high blood sugar value, a low red blood cell count and a low hematocrit value were recognized. histologic examinations revealed the presence of fragments of a n ... | 1981 | 7318930 |
| the changes of hematological and biochemical properties in cynomolgus monkeys (macaca fascicularis) after importation. | 1981 | 7321294 | |
| serum immunoglobulin levels in relation to age in the cynomolgus monkey. | 1981 | 7321296 | |
| breeding performance of the cynomolgus monkey at tsukuba primate center for medical science. | 1981 | 7321298 | |
| natural virus infections in cynomolgus monkeys. | 1981 | 7321300 | |
| naturally occurring diseases in cynomolgus monkeys. | 1981 | 7321301 | |
| projection of precentral, premotor and prefrontal cortex to the basilar pontine grey and to nucleus reticularis tegmenti pontis in the monkey (macaca fascicularis). | in the present autoradiographic study the projections from frontal lobe cortex to basilar pontine grey (gp) and to n. reticularis tegmenti pontis (rtp) have been traced in 24 monkeys. gp receives marked ipsilateral and scant contralateral projections from primary motor as well as from premotor cortex (including supplementary motor area and frontal eye field). this projection terminates in the form of thin lamellae which are folded along the longitudinal axis and which receive the input in a part ... | 1981 | 7323772 |
| innervation of the periodontium in the monkey. | the distribution and structure of the sensory nerves and various neural endings in the periodontium were examined in adult monkeys, macaca irus, by means of the silver nitrate technique. 1. the nerve fibers enter the periodontium passing through the bottom and the lateral wall of the bony socket. they are accompanied by blood vessels after entering the periodontium. 2. in the whole height of the periodontium, the area of richest nerve supply is the apical one third of the tooth root, while fewer ... | 1981 | 7325784 |
| salmonella carriers in the imported cynomolgus monkeys (macaca fascicularis). | 1981 | 7328990 | |
| fatty acid and lipid composition of the monkey retina in diet-induced hypercholesterolemia. | we determined the fatty acid composition of the lipids of cynomolgus monkey retina in animals fed commercial chow or a saturated fat, cholesterol-enriched atherogenic diet for 100 days. doxosahexaenoic acid (22 : 6) accounted for 25.8% of the ethanolamine phosphoglyceride fatty acids, 17.6% of the serine plus inositol phosphoglyceride fatty acids, 8.4% of the choline phosphoglyceride fatty acids and 5.8% of the neutral lipid fatty acids in the retinas of the chow-fed animals. therefore, monkey r ... | 1981 | 7332611 |
| comparative effects of three ocular perfusates on outflow facility in the cynomolgus monkey. | total aqueous outflow facility was determined by two-level constant pressure perfusion of the anterior chamber for 90 minutes in both eyes of cynomolgus monkeys. each monkey received bárány's solution (b, containing no bicarbonate, ascorbate, lactate, urea, sulfate, or amino acids) in one eye and either gaasterland's (g, containing bicarbonate, ascorbate, lactate, urea, sulfate, and amino acids; 8 monkeys) or modified gaasterland's (gm, containing ascorbate, lactate, urea, sulfate, and amino aci ... | 1981 | 7333124 |
| ultrastructure and mode of formation of epiplexus cells in the choroid plexus in the lateral ventricles of the monkey (macaca fascicularis). | the epiplexus cells in the lateral ventricles of the adult monkey (macaca fascicularis) were examined in the electron microscope. the majority of the cells displayed ultrastructural features typical of tissue macrophages, while others resembled monocytes or microglial cells. these cells were characterized by an abundant cytoplasm containing vacuoles, a prominent golgi complex and a variable number of electron-dense granules resembling lysosomes. the cell surface often showed pseudopodial or filo ... | 1981 | 7333962 |
| hyperimmunization of non-human primates with bcg-cw and cultured human glioma-derived cells. production of reactive antisera and absence of eae induction. | the efficacy and non-toxicity of bcg-cell wall preparation (bcg-cw) + cultured human glioma-derived cells as immunogen in non-human primates (macaca fascicularis) were investigated to determine the optimal conditions for immunization without induction of experimental allergic encephalomyelitis (eae). bcg-cw vaccines were prepared with non-irradiated and irradiated (10,000 rads) human glioma cells and used in a short-term hyperimmunization protocol; sera obtained from this regimen were compared t ... | 1981 | 7334081 |
| a study of the major australian snake venoms in the monkey (macaca fascicularis). ii. myolytic and haematological effects of venoms. | rhesus monkeys were kept in a restraining apparatus and while conscious injected with the venoms of a range of australian snakes. although the action of restraining itself caused an elevation of the animals' plasma creatine kinase (c.k.), the rise was up to 5 times greater in envenomed monkeys. the venoms of the tiger snake, mulga, beaked sea snake, rough-scaled, copperhead and red-bellied snakes were all powerfully myolytic, and those of the taipan and small-eyed snake less so. no myolytic acti ... | 1981 | 7335377 |
| [preliminary data on the different endothelial reaction to con a at different levels of the arterial tree in rabbits and in cynomolgus monkeys]. | delayed appearance of atherosclerotic lesions in cerebral arteries has been observed not only in man but also in monkeys and rabbits submitted to atherogenic diets. previous observations of ours had shown a con a positive reaction ("glycocalyx" or "surface coat") at the luminal surface and in the plasmalemmal vesicles of aortic endothelial cells of rabbits an other laboratory animals. the "surface coat" is now reputed the site of lipoproteinlipase activity whose importance in atherogenesis has r ... | 1981 | 7337739 |
| pregnancy diagnosis in macaca fascicularis. hemagglutination inhibition test for urinary chorionic gonadotropin and implantation bleeding. | the subhuman primate pregnancy tube test (shpt test) was useful for early pregnancy diagnosis in cynomolgus monkeys (macaca fascicularis). test results were correct in 86.5% of series of four successive urine samples. shpt test results were not confirmed in 13.5% of series, comprising two (false) negative series in pregnant animals and 13 (false) positive series in nonpregnant animals. in ten of 13 false-positive series, a positive-negative sequence was observed in successive test results, presu ... | 1981 | 7338888 |
| variable schistosoma intercalatum infection in cynomolgus macaques (macaca fascicularis). | 1981 | 7338890 | |
| inheritance and distribution of human-type a-b-o blood groups in cynomolgus monkeys. | 1981 | 7338891 | |
| muscle biopsies from cynomolgus monkeys. | 1981 | 7342564 | |
| a technique for collection and cultivation of macrophages from cynomolgus monkeys (macaca fascicularis). | several techniques were compared for collection of peritoneal mononuclear phagocytes from cynomolgus monkeys. a multiple-holed cannula proved superior to a hypodermic needle for the collection of peritoneal washings because it was not occluded by the omentum. with the cannula technique 55--70% of the harvest medium could be recovered from the peritoneal cavity with a yield of 2.5--5 x 10(5) macrophages per ml. a closed system for injecting and collecting harvest medium was better than a syringe ... | 1981 | 7343772 |
| septicemia and meningoencephalitis caused by listeria monocytogenes in a neonatal macaca fascicularis. | 1981 | 7345144 | |
| metabolism of prostacyclin in cynomolgus monkey. | the metabolism of prostacyclin (pgi2) in vivo was investigated in cynomolgus monkey. following intravenous infusion of 11-[3h]-pgi2 for three days, pooled urine was extracted with amberlite xad-2, then chromatographed and purified by sephadex lh-20, and reverse phase column chromatography. radioactive fractions were converted to appropriate derivatives for identification by gas chromatography mass spectrometry. twelve metabolites were characterized, the major of which was 6-keto-pgf1 alpha, acco ... | 1981 | 7012936 |
| ecology and nature of immunoglobulin a1 protease-producing streptococci in the human oral cavity and pharynx. | the identity and proportional distribution of immunoglobulin a1 (iga1) protease-producing streptococci in the oral and pharyngeal microflora were studied. a collection of 459 streptococcal strains, including reference strains of streptococcus species, and fresh isolates from human dental plaque and buccal and pharyngeal mucosa were identified by biochemical means and were examined for iga1 protease production. iga1 protease production was demonstrated in some, but not all, strains of streptococc ... | 1981 | 7014463 |
| endocrine correlates of sexual development in the male monkey, macaca fascicularis. | 1981 | 7021130 | |
| detection of abo group-specific substances on the red cells of the cynomolgus monkey. | several attempts were made to demonstrate the presence of abo blood group substances on the red blood cells (rbc) of the cynomolgus monkey. neither the direct hemagglutination test nor the antibody absorption test was successful in detecting these substances from whole rbc, the stromata or the butanol extracts of rbc. by the heat elution of antibodies, however, the presence of abh substances was demonstrated on rbc of every phenotype without fail. in all cases, there was a reciprocal relationshi ... | 1981 | 7021929 |
| cardiac allograft survival in cynomolgus monkeys treated with cyclosporin-a in combination with conventional immune suppression. | 1981 | 7022859 | |
| application of morphometrical methods in studies of the mandibular condyle. | two mandibular condyles of a growing monkey (macaca fascicularis) were used for developing and testing a morphometrical model system suitable for generating quantitative data about the structure of and the growth activities in the articulating surface layers. the animal received 3h-proline (1 mci/kg body weight) 24 h and 3h-thymidine (0.5 mci/kg body weight) 3 h prior to killing. using standardized conditions, 1-2 microns thick histological sections were processed for autoradiography. the morpho ... | 1981 | 7028990 |
| influence on periapical tissues of indigenous oral bacteria and necrotic pulp tissue in monkeys. | in nine monkeys (macaca fascicularis) the pulps of 78 teeth were aseptically necrotized. twenty-six of the pulp chambers were kept bacteria-free by sealing, while 52 were infected by the indigenous oral flora. the results were recorded clinically, radiographically and microbiologically at the beginning of the experiment and after 6-7 months. the final examination also included histologic recordings. the initially noninfected root canals were all sterile at the final samplings, indicating that th ... | 1981 | 6951246 |
| histological and histochemical study of the influence of lipopolysaccharide extracted from fusobacterium nucleatum on the periapical tissues in the monkey macaca fascicularis. | 1981 | 6947763 | |
| occlusal dysfunction and stress. an experimental study in macaque monkeys. | a dysfunctional occlusal relationship was produced in six macaca irus monkeys by insertion of occlusal splints which raised the vertical dimension of occlusion by 3--4 mm and incorporated interferences into the occlusion. cortisol levels of plasma and 24 h urine samples were measured by competitive protein-binding analysis. after insertion of the splints there was an immediate, approximately two-fold rise of the mean 24 h urinary cortisol excretion rate and a significant decrease of urinary volu ... | 1981 | 6935390 |
| early pulp changes after anterior maxillary osteotomy. | for purposes of examining the pulpal reaction to segmental osteotomy, six adult female macaca fascicularis monkeys received identical anterior maxillary osteotomies involving the incisors only. the mobilized segment was displaced distally a distance of approximately 2 mm, then splinted in place for a week. the healing and revascularization of the bone proceeded well, with no ischemic areas visible on the microangiograms other than in the animal examined immediately after operation. the osteotomy ... | 1981 | 6935399 |
| acute and chronic effects of intrathecal morphine in monkeys. | in a double-blind study, seven macaca fascicularis monkeys receiving intrathecal (i.t.) morphine in saline, 0.07 mg kg-1, were compared with a control group of four monkeys receiving either lumbar puncture alone (n = 1) or i.t. saline (n = 3). neither morphine nor saline solutions contained preservatives. arterial blood gas tensions, respiration, arterial pressure, e.c.g., state of consciousness and motor function were recorded for 24 h. the control group was sacrificed 42 days later and the stu ... | 1981 | 6895308 |
| virologic control of monkeys used for the production of poliomyelitis virus vaccine. | wild-caught or captive-bred cynomolgus monkeys (macaca fascicularis) used at the national institute of public health for the production of inactivated poliomyelitis virus vaccine are extensively controlled for the presence of antiviral antibodies in their sera. with relatively simple methods of segregation and hygienic measures it seems possible to keep the animals free of infections with certain viruses including herpesvirus simiae and foamy viruses, which is of obvious importance for public he ... | 1981 | 6785124 |
| scrub typhus antibody in cynomolgus monkeys (macaca fascicularis) in malaysia. | using an indirect immunofluorescence technique, sera from 113 cynomolgus monkeys (macaca fascicularis), trapped in peninsular malaysia, were screened for the presence of antibody to six prototype strains of rickettsia tsutsugamushi combined into three polyvalent groupings: i--karp, ta716, and ta763; ii--gilliam; and iii--ta678 and th1817. fifteen percent (17/113) of the monkeys had antibody titers greater than or equal to 1:50 to one or more of the antigenic groups. although a titer greater than ... | 1981 | 6790836 |
| possible synthesis of pregnancy-'specific' beta-1-glycoprotein (sp1) and placenta-'specific' tissue proteins (pp10,pp12) by human and cynomolgus monkey leukocytes. | using an enzyme-bridge immunoperoxidase (pap) technique, it was revealed that pregnancy- and/or placenta-specific proteins, sp1, pp10 and pp12 were localized in human and cynomolgus monkey (macaca fascicularis) polymorphonuclear neutrophils, and pp10, in mononuclear phagocytes. there was no difference in staining results, irrespective of whether the specimens were from human or monkey males, or pregnant or nonpregnant females. the results suggest that sp1, pp10 and pp12 may be synthesized by pol ... | 1981 | 6794297 |
| ultrastructural changes after intracisternal injection of 6-hydroxydopamine in the intermediolateral nucleus of the monkey (macaca fascicularis). | the ultrastructural changes following a single intracisternal injection of 6-ohda were studied in the intermediolateral nucleus of the monkey spinal cord. post-operative survival periods ranged from 20 hours to 14 days. at all stages, only boutons containing clear, round vesicles (r-boutons) and those containing dense-cored vesicles (dcv-boutons) underwent degeneration. boutons containing flattened vesicles (f-boutons) appeared to be unaffected. changes were seen even at 20 hours after injection ... | 1981 | 6799475 |
| hemodynamic and metabolic effects of chronic carbon monoxide exposure in cynomolgus monkeys (macaca fascicularis). | cardio-respiratory data were obtained on four adult female cynomolgus monkeys, intermittently exposed to co for eight months and compared with data obtained from the same animals after five weeks of recovery. due to co exposure, the arteriovenous oxygen concentration difference and oxygen consumption decreased and blood oxygen affinity increased. however, there was no significant change in cardiac output and mixed venous po2. the cynomolgus monkeys adapted to chronic co exposure by reducing thei ... | 1981 | 6806477 |
| pituitary and thyroid function in male cynomolgus monkeys. | in four male cynomolgus monkeys, serum thyroxine was 6.2 +/- 0.9 micrograms/dl, and triiodothyronine was 207 +/- 12 ng/dl (mean +/- se). kinetic studies using 131i-thyroxine and 125i-triiodothyronine showed that the disappearance of both hormones was non-linear and best fit a biexponential equation. the metabolic clearance rates and production rates for thyroxine were 21.5 +/- 0.6 ml/kg/day and 1.34 +/- 0.23 micrograms/kg/day, respectively, and t1/2(beta) = 29.6 +/- 2.0 hours. for triiodothyroni ... | 1981 | 6806535 |
| developmental changes in rabbit and dog adrenal function: a possible homologue of adrenarche in the dog. | histologic, hormonal, and enzymatic studies were performed in the rabbit and dog to identify maturational changes similar to human adrenarche. development of an adrenal reticular zone was observed in both the rabbit and dog, analogous to the change in the man. plasma dehydroepiandrosterone (dha) and androstenedione (delta 4-a) increased significantly in postpubertal compared to prepubertal male rabbits and dogs, but the increases were much smaller than those reported in man. orchiectomy reduced ... | 1981 | 6264794 |
| antisera to late cytomegalovirus nuclear antigens produced in cynomolgus monkeys. | 1981 | 6265560 | |
| functional and anatomical segregation of hypothalamic opiate receptors involved in prolactin and growth hormone secretion in cynomolgus monkeys. | 1981 | 6267401 | |
| patterns of increased metabolic activity in somatosensory cortex of monkeys macaca fascicularis, subjected to controlled cutaneous stimulation: a 2-deoxyglucose study. | 1981 | 6275042 | |
| taste buds of the fungiform papillae in cynomolgus monkey. | a study of the number of taste buds borne on 145 fungiform papillae from 20 cynomolgus monkeys showed that, in contrast to the situation in man, most papillae are bud-bearing. the fine structure of taste buds on fungiform papillae of these monkeys was also examined. the cells contained clear apical vesicles, mitochondria, filament bundles and stacks of golgi cisternae. nerve fibres containing mitochondria, as well as clear and dense-cored vesicles, were scattered throughout the whole bud, but we ... | 1981 | 6277839 |
| absence of antibodies against sv5, measles and herpes simplex in indoor colony-bred cynomolgus monkeys. | one hundred and eighty-one cynomolgus monkeys born and raised at tsukuba primate center for medical science (tpc) were serologically examined for the presence of antibodies against simian virus 5, measles virus and herpes simplex virus. all of them were virtually free from infections with these viruses, whereas wild-originated breeders kept at tpc were highly positive for these antibodies. these results can be regarded as demonstrating that an indoor breeding system such as tpc's is useful and v ... | 1981 | 6278179 |
| immunologic histamine release in vitro from the heart and lung of the cynomolgus monkey. | immunologic histamine release was evoked from the sensitized fragmented cardiac and pulmonary tissue of the cynomolgus monkey by a reverse anaphylactic reaction. ventricular and pulmonary tissue released a similar fraction (approximately 6%) of the total tissue histamine when challenged with antihuman ige, presumably reflecting the 'active' sensitization of the monkey in vivo. passive sensitization of these tissues in vitro resulted in significantly greater immunologic histamine release in 6 of ... | 1981 | 6162802 |
| antigenic and structural relatedness among non-capsid and capsid polypeptides of polioviruses belonging to different serotypes. | antibodies were raised by immunization of macaca fascicularis monkeys with extracts of m. fascicularis kidney cells separately infected with one of the three poliovirus serotypes. preparations of antibodies were shown to be strictly type-specific in the neutralization test but formed immune complexes adsorbable on staphylococcus aureus, cowan i strain cells, with heterotypic as well as homotypic virus-specific polypeptides present in extracts from the virus-infected cells. the presence of intert ... | 1981 | 6169783 |
| angiotensin i conversion by the microcirculation of the nonhuman primate. | previous studies have shown that angiotensin i (ai) is converted to angiotensin ii (aii) by converting enzyme (ce) or by tonin. since all work on tonin has been done in the rodent, its relevance to the primate is yet to be shown. this study examines the conversion of ai to aii by the cheek pouch microcirculation of the monkey (macaca fascicularis). in 9 of the 11 monkeys studied, the conversion of ai to aii was blocked by converting enzyme inhibitor (cei). however, in 2 older monkeys, ai convers ... | 1981 | 6261858 |
| a new candidate type of human enterovirus (drilon strain) isolated in the philippines. | a cytopathogenic agent was isolated in monkey kidney (mk) cell cultures from the stool specimen of a 3-month-old filipina hospitalized with lower respiratory disease. the agent was designated the drilon strain. it was characterized as an enterovirus on the basis of electron microscopic morphology, nucleic acid type (rna), resistance to ether and acid (ph 3.0) treatments, stabilization by molar mgcl2 against heat inactivation, and buoyant density in cscl. the strain caused mild febrile illness in ... | 1981 | 6262605 |
| [immunocytochemical evidence of somatostatin fibers in the neurohypophysis of the monkey macacus irus]. | indirect immunofluorescence technique, using an antisomatostatin antibody, has allowed us to detect immunoreactive fibers in neurohypophysis of the monkey macaca irus. these fibers are located in stem and in neural lobe of the pituitary gland. they are thin fibers disposed around blood vessels. they are grouped together in areas more or less large, especially at the periphery of the neural lobe, under the glandular capsule and in the vicinity of the intermediate lobe. there are no sex-linked dif ... | 1981 | 6115705 |
| high-performance liquid chromatographic determination of lorazepam in monkey plasma. | a simple, sensitive and selective method for the determination of lorazepam in monkey plasma has been developed using high-performance liquid chromatography in a reversed-phase mode. the limit of detection for lorazepam in plasma is about 2 ng/ml. the method has been applied to plasma samples obtained from cynomolgus monkeys after oral doses of 0.15 mg/kg and intravenous doses of 0.05 mg/kg of lorazepam. in this species, mean peak plasma concentrations of 12 ng/ml occurred at 2 h after oral dosi ... | 1981 | 6119319 |
| pharmacokinetics of human interferon-beta in monkeys. | human fibroblast-derived interferon (huifn-beta) was administered to cynomolgus monkeys i.m. (2 x 10(5) iu/kg), i.v. (2 x 10(5) iu/kg) or intrathecally (3 x 10(5) iu/monkey) or given by a 3 hr i.v. infusion (2 x 10(5) iu/kg). one hr after intrathecal administration, interferon titers in the csf were 1000-2000 iu/ml, and declined to less than 10 iu/ml during the first 24 hr. at the same time only minute amounts of huifn-beta were found in the sera of these animals. after i.m. administration, 5 iu ... | 1981 | 6180075 |
| immunization of monkeys (macaca fascicularis) with purified streptococcus mutans glucosyltransferase. | 1981 | 6456717 | |
| the microbiology of ligature-induced periodontitis in the cynomolgus monkey. | 1981 | 6459435 | |
| the isolation of characterization of streptococcus mutans serotype h from dental plaque of monkeys (macaca fascicularis). | a new serotype (h) of streptococcus mutans was isolated from the dental plaque of monkeys (macaca fascicularis). serotype h strains fermented mannitol and melibiose but not sorbitol or raffinose, failed to hydrolyse aesculin and arginine, did not produce hydrogen peroxide and were unable to grow in the presence of bacitracin at 2 units ml-1. sodium dodecyl sulphate-polyacrylamide gel electrophoresis of whole-cell proteins showed serotype h strains to be closely related to strains of genetic grou ... | 1981 | 6460088 |
| dysthyroid orbital disease in macaca fascicularis. | fluctuating left exophthalmos in a mature male macaca fascicularis was studied clinically utilizing the diagnostic modalities of a- and b-scan ultrasonography and computerized tomography in addition to routine ophthalmic examination and radiography. laboratory results were suggestive of thyroid hypofunction. clinical and histopathologic observations were consistent with a diagnosis of dysthyroid orbitopathy, a condition previously unreported in nonhuman primates and the most common cause of unil ... | 1981 | 7343669 |
| standardized method for recording blood pressure in anaesthetized macaca fascicularis. | 1981 | 7265895 | |
| dietary and pharmacologic control of atherosclerosis regression in cynomolgus macaques (macaca fascicularis). | 1981 | 7247734 | |
| tamoxifen effects on mammary gland morphology and ovarian activity in macaca fascicularis. | 1981 | 7200148 | |
| an immunocytological study of the adult crab-eating macaque (macaca fascicularis) pituitary and its cytological differentiation during fetal life. | the pituitaries of adult and fetal crab-eating macaques (macaca fascicularis) have been studied by immunofluorescence using 15 antibodies against most of the known hormones in the adenohypophysis. the antibodies used were first checked on adult pituitaries for their cross-specificity with macaque pituitary hormones. we found five types of endocrine cells reacting positively, according to the biochemical relation of the molecules evidenced with one or more of the antibodies used. the sequential a ... | 1981 | 6760294 |
| [androgen receptors in the fetus of a primate (macaca fascicularis) : preliminary results]. | skin fibroblasts raised from macaca fascicularis skin samples were tested for specific androgen receptors. by the 100th day of gestation male and female skin fibroblasts androgen receptors were detected. higher levels of androgen receptors were found in sex skin fibroblasts. these preliminary results suggest that this primate could be used as a good model for the study of androgen receptors ontogenesis and regulation. | 1981 | 6454467 |
| primates: their use in research on vasectomy. | studies based on experimental vasectomies clearly reveal marked species differences in response to vasectomy. in rats, vasectomy invariably results in granuloma formation at the surgical site. in rabbits, immune-complex orchitis develops. allergic orchitis may also develop in guinea pigs, and the morphological lesions can be adoptively transferred. my co-workers and i have been able to study systematically, biochemically, hormonally, pathologically, and immunologically, primates vasectomized up ... | 1981 | 31995929 |
| on the anatomical organization of the vagal nuclei. | the neurons of origin of the right vagus and its components in both the monkey (macaca fascicularis) and albino rats were localized by the retrograde transport of horseradish peroxidase (hrp) applied to the stomach wall, the vagal trunk and its recurrent laryngeal branch. an attempt was also made to localize the neurons forming the superior laryngeal nerve and those supplying the thoracic organs by a combination of operative procedures. the results showed that the stomach was innervated by neuro ... | 1981 | 31995920 |
| hematological and serum biochemical values in free-ranging macaca fascicularis of mauritius: possible diabetes mellitus and correlation with nutrition. | obtained values are presented from a study of blood biochemistry and hematology of free-ranging crab-eating macaques (macaca fascicularis) in mauritius. normal values are generally comparable to those previously obtained from laboratory populations of this species. abnormal values included elevated serum glucose and triglycerides in certain individuals that suggested glucose intolerance and diabetes mellitus. a high-carbohydrate diet consisting of large proportions of sugar cane and molasses may ... | 1981 | 31995913 |
| a micro-method for the evaluation of pha-responsive t cells in callithrix jacchus and macaca fascicularis. | 1981 | 6802978 | |
| experimental retinal detachment. iv. aqueous humor dynamics in rhegmatogenous detachments. | unilateral rhegmatogenous retinal detachments were produced in 14 cynomolgus monkeys. a total vitrectomy was performed in the fellow eyes. two groups of monkeys were studied two to four months and ten to 19 months after creation of the detachment. aqueous flow was determined fluorimetrically from decay of fluorescein isothiocyanate dextran 70 following anterior chamber injection. outflow facility was measured by constant pressure perfusion. the intraocular pressure was 7.6 and 5.0 mm hg lower in ... | 1982 | 6182869 |
| the nucleotide sequence of cdna coding for preproinsulin from the primate macaca fascicularis. | dna complementary to preproinsulin messenger rna from the primate macaca fascicularis has been cloned into the psti endonuclease site of the plasmid pbr322. one clone contains the entire preproinsulin coding region as well as 59 nucleotides of the 5'-untranslated region. the results predict an amino acid sequence for the macaca fascicularis preproinsulin and establish for the first time that the primary structures of human and primate insulins are identical. the two amino acid exchanges between ... | 1982 | 6184262 |
| a study of malayan filariasis in lubuk mumpo and datar lebar villages in lais regency, north bengkulu, sumatera, indonesia. | filariasis surveys at lubuk mumpo and datar lebar, bengkulu, sumatera, showed microfilarial rates of 23.9% and 30% respectively. periodicity studies showed the parasite to be nocturnally periodic b. malayi with a periodicity index of 82.17. however, unlike the malaysian form of periodic b. malayi, 44-100% of the microfilariae in thick blood smears were sheathed. mansonia annulata, m. bonneae, m. dives, m. uniformis and anopheles nigerrimus are probably involved in the transmission of the disease ... | 1982 | 6133359 |
| comparative pharmacokinetics of frusemide in female rhesus monkeys, cynomolgus monkeys and baboons. | 1. the pharmacokinetics of frusemide have been compared in 3 non-human primate species after single intravenous dose of 3 mg/kg of the drug. 2. peak mean plasma concentrations of frusemide were 31.6, 33.6, 43.6 micrograms/ml in the rhesus monkey, cynomolgus monkey and baboon respectively, and concentrations declined with a half-life of about 20 min. 3. there were no notable differences in the pharmacokinetic parameters estimated from either a one-compartment or two-compartment open model. 4. the ... | 1982 | 6121675 |
| effects of buspirone on operant behavior of laboratory rats and cynomolgus monkeys. | rats trained on an avoidance-escape task were administered buspirone in doses ranging from 0.5 to 7.5 mg/kg. low doses disrupted avoidance responding without impairing escape responding. rats trained on an experimentally induced conflict procedure were also administered buspirone or diazepam (1.0 to 5.0 mg/kg). buspirone and diazepam appeared to be equipotent as anxiolytics. cynomolgus monkeys, also trained on the experimentally induced conflict task, were given intramuscular buspirone or diazep ... | 1982 | 6130070 |
| somatostatin and vip neurons in the retina of different species. | neurons displaying somatostatin or vasoactive intestinal polypeptide (vip) immunoreactivity were detected among the amacrine cells in the retina of baboon, cynomolgus monkey, squirrel monkey, cow, pig, cat, rabbit, guinea-pig, rat, mouse, frog and goldfish. generally, immunoreactive cell bodies were located in the inner nuclear layer with processes ramifying in three more or less well-defined sublayers in the inner plexiform layer. the density of the sublayers and their location varied with the ... | 1982 | 6131054 |
| ocular neovascularization with retinal vascular occlusion. i. association with experimental retinal vein occlusion. | experimental occlusion of both major temporal retinal veins simultaneously (in six eyes of cynomolgus monkeys) and of the central retinal vein (in one rhesus monkey) produced a fall in intraocular pressure (hypotensive effect) and neovascularization (nv) of the iris and, less frequently, of the optic disc (vasogenic effect). the retinal changes (severity and extent of retinopathy, retinal capillary leakage, and onset and extent of retinal capillary obliteration) were correlated with the pattern ... | 1982 | 6175297 |
| experimental vascularized total joint autografts--a primate study. | autogenous vascularized and nonvascularized total joint transfers were studied in the hands of macaca fascicularis monkeys. nine second toe proximal interphalangeal joints were transferred as a vascularized free graft to the hand, and the excised finger joints were transferred to the foot as a nonvascularized free graft. the grafts were examined clinically and histopathologically at 16 weeks to 10 months. two of the nonvascularized free grafts were amputated because of infection and necrosis. th ... | 1982 | 6175680 |
| involvement of the kidney in catabolism of human leukocyte interferon. | the metabolic fate of human leukocyte interferon (huifn-alpha) was studied after intravenous injection into rats and cynomolgus monkeys. at various intervals the animals were sacrificed and the huifn-alpha content determined in serum and various tissues. huifn-alpha quickly disappeared from the circulation and was found mainly in the kidneys, in which levels were at least 7- to 10-fold higher than in the liver, spleen, lungs, heart, brain and muscles. no interferon was detected in urine. subcell ... | 1982 | 6175730 |
| characterization of rickettsia tsutsugamushi strains in two species of naturally infected, laboratory-reared chiggers. | the strains of rickettsia tsutsugamushi found in naturally infected, laboratory-reared leptotrombidium (leptotrombidium) arenicola and l. (l.) fletcheri chiggers were characterized by direct immunofluorescence (fa) and by mouse and monkey virulence tests. the strains existing in the l. (l.) arenicola chiggers consisted of different combinations of ta716, ta763, ta686, karp, and kato. in addition to these five strains, gilliam was found in the l. (l.) fletcheri chiggers. results indicate that ind ... | 1982 | 6176132 |
| regulation of the synthesis and release of slow-reacting substance of anaphylaxis from sensitized monkey lung. | immunological challenge of sensitized fragmented cynomolgus monkey lung with anti-human ige (immunoglobulin e) induced the appearance of slow reacting substance of anaphylaxis (srs-a) in the tissue and evoked the release of srs-a into the tyrode's supernatant. the elevation of tissue or residual srs-a levels was maximal 2 min after anti-ige challenge and remained at that plateau for at least 60 min. the released srs-a, first detectable 3 to 5 min after challenge, achieved a plateau by 10 min. bo ... | 1982 | 6176708 |
| histochemical evidence for the existence of skeletofusimotor (beta) innervation in the primate. | a total of ten alpha motor axons which innervated the peroneus brevis muscle were isolated in two cynomolgus monkeys. in each experiment, the isolated alpha axons were stimulated collectively to deplete glycogen from their muscle units. the muscle was then frozen quickly , cut serially, and stained for glycogen. of the 52 muscle spindles that were examined, zones of glycogen depletion were found in the intrafusal fibres of 32 spindles. the glycogen-depleted motor units included both fast-twitch ... | 1982 | 6212260 |
| [immunoflurorescence demonstration of cells reacting with an antipancreatic polypeptide antibody in the intestine of the monkey macacus irus]. | indirect immunofluorescence technique using an antibody against bovine pancreatic polypeptide has allowed us to detect immunoreactive cells in the small intestine of the monkey macaca irus. these cells are located almost exclusively in the wall of lieberkuhn's glands, especially in the jejunum and, in a smaller number, in the duodenum; these cells are scattered, always isolated, never in clusters; immunoreactive cells were never seen in the colon. there were no sex-linked differences in the morp ... | 1982 | 6215096 |
| isolation of human rotaviruses in primary cultures of monkey kidney cells. | we succeeded in isolating human rotaviruses from the feces of gastroenteritis patients by using roller cultures of primary cynomolgus monkey kidney cells with trypsin in the maintenance medium but without concentration and trypsin treatment of the inocula at each passage level. these cells were found to be more sensitive than ma-104 cells (derived from fetal rhesus monkey kidney) for the propagation of human rotaviruses. polyacrylamide gel electrophoresis of the genome rna revealed that there we ... | 1982 | 6288768 |
| electron microscopy of aminergic retinal neurons. | the synaptic connections of the dopaminergic retinal neurons of cynomolgus monkeys and rabbits were studied in the electron microscope. in the cynomolgus monkeys, a labelling method with 5,6-dihydroxytryptamine was used, whereas an autoradiographic technique with a monoamine oxidase inhibitor and (3h)-dopamine was used in the rabbits. the labelling method with 5,6-dihydroxytryptamine altered the normal ultrastructure of the dopaminergic neurons, but their synaptic structures were still easily re ... | 1982 | 6291309 |
| natural transmission of entamoeba histolytica from mother cynomolgus monkeys (macaca fascicularis) to their newborn infants under indoor rearing conditions. | natural transmission of entamoeba histolytica from infected mother cynomolgus monkeys (macaca fascicularis) to their newborn infants was investigated by the stool examination under indoor individually-caged conditions. every infant became positive for e. histolytica between 5 and 10 weeks after birth. although some infants were demonstrated to harbor the trophozoites, no overt amebic diarrhea occurred in any of the infants throughout the period of this study. | 1982 | 6291957 |
| malignant nephroblastoma in macaca fascicularis. | a case of malignant nephroblastoma was identified in a 4.5-month-old female macaca fascicularis. the age of onset, clinical history, gross and microscopic pathology, and the pulmonary metastasis were analogous to this condition as seen in man. | 1982 | 6292577 |
| the morphology and connections of the posterior hypothalamus in the cynomolgus monkey (macaca fascicularis). i. cytoarchitectonic organization. | the cytoarchitectonic organization of the posterior hypothalamus of the cynomolgus monkey (macaca fascicularis) was analyzed in nissl, golgi, acetylcholinesterase, and reduced silver preparations. the region consists of a number of cell masses that differ considerably in their discreteness and in the homogeneity of their neuronal populations. the nuclei identified include: the medial mamillary nucleus (in which at least three distinct subdivisions can be recognized--a pars medialis, a pars later ... | 1982 | 6808030 |
| the morphology and connections of the posterior hypothalamus in the cynomolgus monkey (macaca fascicularis). ii. efferent connections. | the efferent connections of the posterior hypothalamus have been analyzed autoradiographically in a series of eight cynomolgus monkey (macaca fascicularis) brains with injections of 3h-amino acids in different regions of the mamillary complex and the surrounding areas. the medial mamillary nucleus was found to project through the mamillothalamic tract to the ipsilateral anteroventral, anteromedial, and interanteromedial nuclei, and by way of the mamillotegmental tract principally to the deep teg ... | 1982 | 6808031 |
| hepatic microsomal enzyme induction by aroclors 1248 and 1254 in cynomolgus monkeys. | aroclors 1248 (2 mg/kg body weight) and 1254 (5 mg/kg body weight) produced a 3-methylcholanthrene type of mixed-function oxidase induction, in the livers of adult female cynomolgus monkeys after 69-122 days of dosing, when the animals were moribund. both aroclor 1248 and 1254 produced a mixed pattern of induction in mouse liver 66 hr after ip treatment with 1000 mg/kg body weight including changes characteristic of 3-methylcholanthrene-type induction. however the same dose of aroclor 1016 did n ... | 1982 | 6809545 |
| follicle dominance and ovarian asymmetry after luteectomy in rhesus monkeys. | previous work demonstrated that asymmetrical ovarian activity accompanies morphological asymmetry during the ovarian cycle in rhesus and cynomolgus macaques. this study was designed to determine whether functional ovarian asymmetry could be used to detect the upcoming dominant follicle (df) even before it was grossly visible. revealing a latent df in this manner would permit a better estimate of the time when dominance of the follicle selected to ovulate is attained. to accomplish this, rhesus m ... | 1982 | 6812434 |
| effect of polychlorinated biphenyls and polychlorinated quaterphenyls in cynomolgus monkey (macaca fascicularis). | female cynomolgus monkeys (macaca fascicularis) with p-kc-400, y-pcb, py-pcb or polychlorinated quaterphenyls (pcq) received a daily dose of 5 mg for 20 weeks, and some monkeys received a daily dose of 10 mg of y-pcb or 0.5 mg of pcq. the chemical compositions of the polychlorobiphenyls (pcb) used for the oral administration were as follows: p-kc-400, pcb from which polychlorodibenzofurans (pcdf) have been removed from kanecklor 400, largely contains tri- and tetrachlorobiphenyls and no pcdf. wh ... | 1982 | 6814017 |
| [menstrual cycle lengths and the estimated time of ovulation in the cynomolgus monkey (macaca fascicularis)]. | establishing of an efficient system for the judgement of an optimal mating time is an important prerequisite for the successful development of a large scale breeding of macaques as laboratory animals. in general, an optimal mating time has been judged on the basis of individual records of menstruation. the length of the previous menstrual cycle has usually been used for the prediction of the next cycle length. in the present study, the lengths of 240 menstrual cycles of 60 cynomolgus monkeys of ... | 1982 | 6814931 |
| effect of mannitol on experimental focal ischemia in awake monkeys. | the effect of mannitol on focal cerebral ischemia in cynomolgus monkeys was studied. after the implantation of a snare ligature about the right middle cerebral artery (mca) and of deep electrodes for measurement of cerebral blood flow, unanesthetized animals underwent 4-hour mca occlusion. ten monkeys were untreated, and 12 animals received mannitol (1.2 g/kg i.v.) 20 minutes after occlusion. the preocclusion and postocclusion deep hemispheric cerebral blood flows (mean cbfs) were similar in the ... | 1982 | 6815550 |
| polychlorinated biphenyl toxicity in the pregnant cynomolgus monkey: a pilot study. | 1982 | 6816151 | |
| some observations on hypothalamo-amygdaloid connections in the monkey. | the projections of the hypothalamus to the amygdala have been studied autoradiographically in a series of eleven cynomolgus monkeys (macaca fascicularis) in which injections of [3h]amino acids had been made in different regions of the caudal two-thirds of the hypothalamus. the most prominent projection arises from the ventromedial nucleus of the hypothalamus and terminates most heavily in the medial, magnocellular division of the central nucleus. injections confined to the ventromedial nucleus a ... | 1982 | 6816388 |
| a method to evaluate the biosynthesis of glycosaminoglycans by the aorta of cynomolgus monkey. | the biosynthesis of the glycosaminoglycans (gags) was investigated in vitro in the aortic tissue of the cynomolgus monkey incubated with [14c]glucosamine. with the use of a new micromethod, it was possible to quantify the glycosaminoglycans and their radioactive distribution in the aortic tissue and incubation medium. labeled and nonlabeled chondroitin 6-sulfate, dermatan sulfate, heparan sulfate and hyaluronic acid were measured. since the sensitivity of this procedure is between 5 and 20 micro ... | 1982 | 6818978 |