Publications

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suppression of plasmodium falciparum malaria in aotus monkeys by milk diet. 19734200243
glomerular changes in acute plasmodium falciparum infection. an immunopathologic study. 19734200428
immunoglobulin characteristics of antibodies to malarial s-antigens in man. 19734200439
transmission of three strains of plasmodium falciparum from monkey to man. 19734200700
heterologous immunity in human malaria. 19734201093
enzyme typing of malaria parasites.analysis of various isolates of plasmodium falciparum from east and west africa and from south-east asia showed that some of the parasite enzymes can exist in more than one electrophoretic form. at least one form of each enzyme was common to parasites from all three regions. the enzyme forms could be used to differentiate morphologically indistinguishable samples of p. falciparum.19734196338
plasmodium falciparum and p. knowlesi: low temperature preservation using dimethylsulfoxide. 19734197973
cross immunity studies with east and west african strains of plasmodium falciparum in owl monkeys (aotus trivirgatus). 19734198111
prophylaxis of malaria in man using the sulfone dfd with pyrimethamine. 19734198482
sulfalene with pyrimethamine and chloroquine with pyrimethamine in single-dose treatment of plasmodium falciparum infections. a trial in a rural population in northern nigeria.a comparative trial was carried out in northern nigeria of the ability of the drug combinations chloroquine-pyrimethamine and sulfalene-pyrimethamine to clear the peripheral blood stream of asexual forms of p. falciparum within 7 days. the reappearance of asexual p. falciparum forms within the 70-day follow-up period and the occurrence of vomiting during the 2-3 hours following administration of the drugs were also recorded. the purpose of the trial was to choose the more suitable of the two dru ...19734603037
migrant populations and the diffusion of the sickle-cell gene. 19734582014
[the erythrogram in treated and untreated malaria patients in western africa]. 19734582401
letter: falciparum malaria resistant to chloroquine suppression but sensitive to chloroquine treatment in west malaysia. 19734593652
feasibility of computer screening of blood films for the detection of malaria parasites.this paper considers the feasibility of automatic screening procedures for detecting malaria parasites in blood smears prepared in the field. a simple programme for pattern recognition by computer has been developed for thin blood films that identifies parasites as densely stained particles within an erythrocyte. the parasites are detected correctly, but platelets falling accidentally within the outline of an erythrocyte and perhaps reticulocytes may be wrongly classified as parasites. the resul ...19734578363
sir ronald ross and the evolution of malaria research. 19734580853
enzyme variation in plasmodium falciparum in the gambia. 19734596374
ferrokinetics in patients with malaria: normoblasts and iron incorporation in vitro. 19734578467
blackwater fever in kenya: problems of etiology. 19734578485
the evaluation of quinine alone or in combination with tetracycline and pyrimethamine against falciparum malaria in thailand. 19734584107
characterisation of a drug resistant strain of plasmodium falciparum from sabah. 19734582746
[parasitology and splenomegaly]. 19734599750
hemoglobin a 2 and malaria. 19734569541
[cases of malaria in sweden]. 19734595437
influence of sulfalene upon gametocytogenesis of plasmodium falciparum and subsequent infection patterns in anopheles stephensi. 19734570982
[primary infection malaria. detection by bone marrow examination]. 19734575188
the chemotherapy and prophylaxis of malaria. 19734590861
letter: delayed attacks of malaria in visitors to the tropics. 19734591006
letter: resistance to chloroquine of plasmodium falciparum from sabah. 19734591211
letter: effect of sulphamethoxazole-trimethoprim on the viability of plasmodium falciparum gametocytes. 19734591212
the direct antiglobulin test and immunoconglutinin titres in patients with malaria. 19734591219
on the nature of orthostatic hypotension in acute malaria. 19734577812
letter: quinine and chloroquine antagonism in falciparum malaria. 19734591506
[the treatment of plasmodium falciparum malaria in the region of bobo-dioulasso, upper volta]. 19734597412
a phenanthrene methanol (wr 33063) for treatment of acute malaria.wr 33063, a phenanthrene methanol, was studied in human volunteers for tolerance and toxicity. in normal volunteers, it was possible to give 4.6 g in four divided doses without adverse effect for 10 days. at this dose level, there was neither evidence of photosensitivity nor adverse renal or cardiac effect. at a dose level of 1.6 g in four divided doses for 6 days, wr 33063 cured 18 of 23 nonimmune volunteers infected with the smith strain of plasmodium falciparum from vietnam. in addition, infe ...19734597714
malaria and filariasis in a transmigration village eight and twenty-two months after establishment. 19734595581
malaria and mediterranean history. 19734596191
a quinoline methanol (wr 30090) for treatment of acute malaria.wr 30090 at a dose of 230 mg every 8 hr for 6 days has proven to be a safe, well-tolerated compound with photosensitivity proving to be a minor consideration. wr 30090 was found to be an effective medication for the treatment of acute malaria caused by several strains of plasmodium falciparum. at the dose of 230 mg every 8 hr for 6 days, all of six men infected with a chloroquine-susceptible strain (uganda i) were cured, all of 13 subjects infected with moderately chloroquine-resistant strains ( ...19734597715
prophylactic activity of a phenanthrene methanol (wr 33063) and a quinoline methanol (wr 30090) in human malaria.wr 33063 (3-bromo-10-[alpha-hydroxy-beta-(n, n-diheptylamino)ethyl]-phenanthrene hydrochloride) and wr 30090 (6,8-dichloro-2,3,4-dichlorphenyl-di-n-butylaminoethyl-4- quinolinemethanol hydrochloride) were tested for suppressive prophylactic effect on induced malaria in nonimmune volunteers living in an area where malaria is not naturally transmitted. doses of 800 mg of wr 33063 and 690 or 460 mg of wr 30090 were given at weekly intervals to men exposed on the day of the first dose to mosquitoes ...19734597716
treatment of falciparum malaria from vietnam with a phenanthrene methanol (wr 33063) and a quinoline methanol (wr 30090).two new investigational antimalarial drugs developed by the u.s. army malaria research program were tested in patients with multi-drug-resistant falciparum malaria from vietnam. wr 33063, a phenanthrene methanol, cured 13 patients treated in the united states. all of these patients had suffered multiple recrudescences after treatment with standard antimalarial drugs. in addition, 23 of 25 patients with acute attacks of falciparum malaria treated in vietnam were cured. the rate of clinical respon ...19734597717
second roundtable discussion on taxonomic problems relating to malaria parasites. 19734632261
malaria in china and the equatorial pacific area from 1937 to 1943. 19734611054
rigidity of red cell during malarial infection. 19734632768
the challenge of drug-resistant malaria. 19734631761
igm antibodies to red cells and autoimmune anemia in patients with malaria. 19734631762
[report on malaria in the southern sahara nomads]. 19744619050
prophylactic activity of mefloquine hydrochloride (wr 142490) in drug-resistant malaria.in preliminary studies with mefloquine (wr 142 490) a single dose exerted prolonged suppressive activity against a drug-resistant strain of plasmodium falciparum. development of patent parasitaemia was prevented when nonimmune persons were exposed to infected mosquitos 2 weeks after medication, and it was delayed when exposure occurred 3 weeks after drug administration.19744619059
antifolic combinations in the treatment of malaria.for the treatment of malaria, combinations of drugs with antifolic action have the great advantage, compared with other drug associations, of synergic action, which increases the effectiveness of the preparation, limits its toxicity, and reduces the risk of resistance. the associations of a sulfonamide (sulfalene, s) with a diaminopyrimidine derivative (pyrimethamine, p, or trimethoprim, t) have given good immediate clinical results. an analysis of the pharmacodynamic and pharmacokinetic charact ...19744613504
[endemic malaria. diagnostic problems]. 19744618791
[study of the parasitic etiology of idiopathic african splenomegalies]. 19744618796
tropical pathology. 19744619032
complement activation in children with acute malaria. 19744619598
preliminary report of in vitro and in vivo studies on falciparum malaria in thailand. 19744610783
[malaria is imported; prevention is vitally important for travelers to the tropics]. 19744611079
clinical testing of new antimalarial compounds.more than 200 000 chemical compounds have been screened for antimalarial activity over the past 10 years by the us army antimalarial drug development program. by means of extensive animal testing, 26 of these compounds were selected for clinical study in human subjects volunteering for such trials. of these, 7 have received complete clinical trials and are in various stages of field evaluation, 4 are currently undergoing clinical trial, and 2 are still awaiting testing in volunteer subjects. thu ...19744613503
immunization and other prophylactic measures. 19744613420
early diagnosis and clinical picture of malaria.as a result of extensive travel and temporary residence by people in areas where malaria is endemic, the disease is being reimported into countries from which it has been eradicated. owing to the lack of experience of malaria on the part of present-day physicians and the atypical presentation of some forms of the disease, it is not always recognized, which in the case of falciparum malaria may have grave consequences. in every case of an unexplained fever the possibility of malaria should be tak ...19744613500
[diagnosis and treatment of cerebral malaria in nonendemic areas]. 19744613501
a malaria model tested in the african savannah.a new mathematical model of malaria has been developed for comparing the effects of alternative control measures. it describes both the temporal changes of the p. falciparum infection rate and the immunity level of the population as a function of the dynamics and characteristics of the vector populations, which are summarized in the concept of vectorial capacity. a critical vectorial capacity is specified, below which malaria cannot maintain itself at an endemic level. the model has been tested ...19744613512
antimalarian precautions for scandinavian tourists. 19744615297
studies on the chemotherapy of malaria. (iii). treatment of falciparum malaria in the gambia, with brl 50216 (4,6-diamino-(3, 4-dichlorobenzyloxy)-1,2-dihydro-2 2-dimethyl-1,3,5-triazine hydrochloride) alone and in combination with sulphonamides,. 19744617937
treatment of drug-resistant malaria in man.the progressive spread in asia and south america of falciparum malaria resistant to 4-aminoquinolines, and the focal occurrence in all malarious regions of infections resistant to dihydrofolate dehydrogenase inhibitors such as pyrimethamine and proguanil, make it everywhere necessary to be alert to the failure of accepted curative, prophylactic, or sporontocidal chemotherapeutic agents. resistance to 4-aminoquinolines may be met curatively with courses of treatment lasting 1-14 days, or more, th ...19744613507
mechanisms of acquired immunity and epidemiological patterns of antibody responses in malaria in man.this paper considers the participation of macrophages, thymus-dependent lymphocytes (t-cells), and thymus-independent lymphocytes (b-cells) in man's immune response to malaria. although phagocytosis by macrophages is an important feature of malaria the full extent of cooperation between these cells and t- and b-cells is not known. evidence that t-cells play an important defensive role is at present unconvincing. b-cells on the other hand function importantly in the synthesis of immunoglobulins a ...19744613508
imported malaria.there have been 4 waves of imported malaria in the usa. they occurred during the colonization of the country and during the second world war, the un police action in korea, and the viet-nam conflict. the first 3 episodes are briefly described and the data on imported malaria from viet-nam are discussed in detail.endemic malaria is resurgent in many tropical countries and international travel is also on the rise. this increases the likelihood of malaria being imported from an endemic area and int ...19744613510
acetylator phenotype in sulphonamide resistant falciparum malaria. 19744614725
[plasmodium falciparum malaria after extracorporeal circulation]. 19744603742
acute falciparum malaria. complications and treatment. 19744615381
experiences with malaria in the early phase of australian army involvement in south vietnam. 19744616150
new perspectives on the chemotherapy of malaria, filariasis, and leprosy. 19744616264
gastrointestinal function, quinine absorption and parasite response in falciparum malaria. 19744617310
recrudescence, poor response or resistance to quinine of falciparum malaria in thailand. 19744617311
intestinal parasites and malaria in the bada and gimpu areas of central sulawesi, indonesia. 19744617312
preliminary survey for chloroquine resistant malaria in parts of north sumatra, indonesia. 19744617314
longitudinal malaria studies in rural north-east thailand: demographic and temporal variables of infection.a prospective longitudinal study of malaria incidence was carried out in randomly selected samples of the population in the villages of bu phram and tablan, north-east thailand. during the 10-month study period 46% of the 252 persons followed up experienced a falciparum parasitaemia, and 23% a vivax parasitaemia. the peak of the cases occurred during a 10-week period from late may to the end of july, with transmission apparently continuing, at lower levels, throughout the remainder of the study ...19744617638
specificity of the indirect haemagglutination test with plasmodium falciparum test cells. comparison of indirect haemagglutination and fluorescent antibody tests on african sera.the specificity of the indirect haemagglutination (iha) test with plasmodium falciparum placental antigen-sensitized test cells was examined with sera from healthy blood donors and from patients with diseases other than malaria. only 1 nonspecific antibody reaction was seen in more than 700 tests. a comparison of iha titres and indirect fluorescent antibody (ifa) titres with igg and igm conjugates on 503 sera from inhabitants of mto wa mbu in tanzania showed in successive age groups an increasin ...19744617639
blood coagulation and platelet agglutinin studies in acute falciparum malaria. 19744599021
[malaria prevention for swedish tourists in west-africa]. 19744618344
[vaccination centers give insufficient information]. 19744618345
the use of antimalarial drugs. 19744605355
[malaria]. 19744605779
a comparison between the quinine and chloroquine regimens for falciparum malaria in vietnam. 19744599322
the sites of sequestration of the uganda-palo alto strain of plasmodium falciparum-infected red blood cells in the squirrel monkey, samimiri sciureus. 19744600380
editorial: drugs for prevention of malaria. 19744606469
imported infections. unexplained fever. 19744609557
[falciparum malaria in childhood (author's transl)]. 19744619622
crises in malaria. 19744610527
serum folate and folic acid absorption in patients with plasmodium falciparum malaria. 19744610778
acute pulmonary insufficiency in falciparum malaria: summary of 12 cases with evidence of disseminated intravascular coagulation. 19744603133
management of malaria exposure among aircrew members. i. etiology. 19744611184
the blood groups and haemoglobins of the kunama and baria of eritrea, ethiopia. 19744611324
[cerebral tropical malaria with blackwater fever. a current diagnostic and therapeutic problem]. 19744612704
letter: transplacental malaria transmisson. 19744596496
[benign plasmodium falciparum infections in the netherlands]. 19744596536
preliminary study of wr 33063 in the treatment of falciparum malaria in northeast thailand. 19744603134
evaluation of clindamycin in combination with quinine against multidrug-resistant strains of plasmodium falciparum. 19744603135
cerebral malaria. on the nature and significance of vascular changes. 19744609762
intestinal parasites and malaria in the poso valley, central sulawesi, indonesia. 19744610779
quinine fever in falciparum malaria. 19744610781
cross immunofluorescent reactions between human and rodent malaria. 19744594072
comparative efficiency of anopheles stephensi and anopheles gambiae as vectors of drug-resistant plasmodium falciparum from thailand. 19744594077
proceedings: serological surveys in the tropics: reliability of the method of collecting blood on absorbent paper. 19744594467
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