Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| metabolic modeling of energy balances in mycoplasma hyopneumoniae shows that pyruvate addition increases growth rate. | mycoplasma hyopneumoniae is cultured on large-scale to produce antigen for inactivated whole-cell vaccines against respiratory disease in pigs. however, the fastidious nutrient requirements of this minimal bacterium and the low growth rate make it challenging to reach sufficient biomass yield for antigen production. in this study, we sequenced the genome of m. hyopneumoniae strain 11 and constructed a high quality constraint-based genome-scale metabolic model of 284 chemical reactions and 298 me ... | 2017 | 28600895 |
| comparison of gene expression of toll-like receptors and cytokines between piau and commercial line (landrace×large white crossbred) pigs vaccinated against pasteurella multocida type d. | we aimed to compare toll-like receptors (tlr) and cytokines expression in local piau breed and a commercial line (landrace×large white crossbred) pigs in response to vaccination against pasteurella multocida type d. seronegative gilts for pasteurella multocida type d and mycoplasma hyopneumoniae were used, from which peripheral blood mononuclear cells (pbmc) were collected in four time points (t0, t1, t2 and t3; before and after each vaccination dose). for bronchoalveolar lavage fluid cells (bal ... | 2017 | 28554143 |
| provision of straw by a foraging tower -effect on tail biting in weaners and fattening pigs. | straw is one of the most effective rooting materials to reduce tail biting in pigs. a so-called foraging-tower (ft) provides only small quantities of straw compatible with liquid manure systems. the focus of the present study was on the effect of providing straw by ft in order to prevent tail biting in tail docked pigs. four consecutive batches of 160 pigs, randomly divided into a straw (sg) and a control group (cg) were followed up from weaning to slaughter. | 2017 | 28405460 |
| field efficacy of porcilis® pcv m hyo versus a licensed commercially available vaccine and placebo in the prevention of prdc in pigs on a french farm: a randomized controlled trial. | a controlled, randomised, and blinded trial performed on a conventional french farrow-to-finish farm compared the efficacy of a one-shot bivalent ready to use vaccine, porcilis® pcv m. hyo (group pcvm), to that of two commercial vaccines (ingelvac® circoflex® + ingelvac® mhyo, group icim), and to a placebo (group ctl), in preventing the health and economic impacts of porcine respiratory disease complex (prdc). | 2017 | 28405459 |
| pro-apoptotic effect of a mycoplasma hyopneumoniae putative type i signal peptidase on pk(15) swine cells. | mycoplasma hyopneumoniae is an economically significant swine pathogen that causes porcine enzootic pneumonia (pep). important processes for swine infection by m. hyopneumoniae depend on cell surface proteins, many of which are secreted by secretion pathways not completely elucidated so far. a putative type i signal peptidase (spase i), a possible component of a putative sec-dependent pathway, was annotated as a product of the sips gene in the pathogenic m. hyopneumoniae 7448 genome. this m. hyo ... | 2017 | 28284605 |
| a novel chimeric protein composed of recombinant mycoplasma hyopneumoniae antigens as a vaccine candidate evaluated in mice. | enzootic pneumonia (ep) is caused by the mycoplasma hyopneumoniae pathogenic bacteria, and it represents a significant respiratory disease that is responsible for major economic losses within the pig industry throughout the world. the bacterins that are currently commercially available have been proven to offer only partial protection against m. hyopneumoniae, and the development of more efficient vaccines is required. several recombinant antigens have been evaluated via different immunization s ... | 2017 | 28284602 |
| a randomized controlled study on the efficacy of a novel combination vaccine against enzootic pneumonia (mycoplasma hyopneumoniae) and porcine circovirus type 2 (pcv2) in the presence of strong maternally derived pcv2 immunity in pigs. | mycoplasma hyopneumoniae (m. hyo) and porcine circovirus type 2 (pcv2) are major pathogens that cause significant health problems in swine worldwide. maternal derived immunity (mdi) has been suggested as a significant immediate defence factor for newborn piglets and may interfere with piglet's vaccination-induced immunity. the study aimed to assess the efficacy of a novel combination vaccine (consisting of pcv2 subunits and inactivated m. hyo strain j), against pcv2 and m. hyo natural infection ... | 2017 | 28388953 |
| potential use of local and systemic humoral immune response parameters to forecast mycoplasma hyopneumoniae associated lung lesions. | immunopathological events are key for the development of enzootic pneumonia (ep), which is macroscopically observed as cranioventral pulmonary consolidation (cvpc). this study aimed to investigate the putative association between the humoral immune response against mycoplasma hyopneumoniae (m. hyopneumoniae) and prevalence and extension of cvpc in 1) experimentally infected pigs, 2) slaughtered pigs and 3) sequentially necropsied pigs in a longitudinal study. cvpc was scored by means of the euro ... | 2017 | 28380065 |
| serum acute phase response induced by different vaccination protocols against circovirus type 2 and mycoplasma hyopneumoniae in piglets. | the purpose of this study was to compare the acute phase reaction (apr) induced by different vaccination protocols used against porcine circovirus (pcv) type-2 and mycoplasma hyopneumoniae (m.hyo), studying two acute phase proteins (apps) and changes in rectal temperature (rt). in addition, the possible influence of the time of vaccination and breed were analysed. in the first experiment, 40 commercial crossbred piglets were vaccinated, on the day of weaning, with flexcombo® (group a, n=20) or p ... | 2017 | 28324811 |
| assessment of the adjuvant activity of mesoporous silica nanoparticles in recombinant mycoplasma hyopneumoniae antigen vaccines. | the adjuvant potential of two mesoporous silica nanoparticles (msns), sba-15 and sba-16, was assessed in combination with a recombinant hsp70 surface polypeptide domain from mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia (pep). the recombinant antigen (hsp70212-600), previously shown as immunogenic in formulation with classic adjuvants, was used to immunize balb/c mice in combination with sba-15 or sba-16 msns, and the effects obtained with these formulations were ... | 2017 | 28194450 |
| impact of diversity of mycoplasma hyopneumoniae strains on lung lesions in slaughter pigs. | the importance of diversity of mycoplasma hyopneumoniae (m. hyopneumoniae) strains is not yet fully known. this study investigated the genetic diversity of m. hyopneumoniae strains in ten pig herds, and assessed associations between the presence of different strains of m. hyopneumoniae and lung lesions at slaughter. within each herd, three batches of slaughter pigs were investigated. at slaughter, from each batch, 20 post mortem bronchoalveolar lavage fluid samples were collected for multiple lo ... | 2017 | 28095890 |
| effects of mycoplasma hyopneumoniae on porcine nasal cavity dendritic cells. | mycoplasma hyopneumoniae (mhp) is the primary etiological agent responsible for swine enzootic pneumonia (ep), a disease that cause tremendous economic losses all over the swine industry. dendritic cells (dcs), the most effective antigen-presenting cells, are widely distributed beneath respiratory epithelium. dcs uptake and present antigens to t cells, to initiate protective immune responses or generate immune-mediated pathology in different infections. in this study, we investigated the changes ... | 2017 | 28061998 |
| secretomes of mycoplasma hyopneumoniae and mycoplasma flocculare reveal differences associated to pathogenesis. | mycoplasma hyopneumoniae and mycoplasma flocculare cohabit the porcine respiratory tract. however, m. hyopneumoniae causes the porcine enzootic pneumonia, while m. flocculare is a commensal bacterium. comparative analyses demonstrated high similarity between these species, which includes the sharing of all predicted virulence factors. nevertheless, studies related to soluble secretomes of mycoplasmas were little known, although they are important for bacterial-host interactions. the aim of this ... | 2017 | 28003119 |
| evolution and function of the mycoplasma hyopneumoniae peroxiredoxin, a 2-cys-like enzyme with a single cys residue. | the minimal genome of the mollicute mycoplasma hyopneumoniae, the etiological agent of porcine enzootic pneumonia, encodes a limited repertoire of antioxidant enzymes that include a single and atypical peroxiredoxin (mhprx), whose evolution and function were studied here. mhprx has only one catalytic cysteine, in contrast with some of its possible ancestors (2-cys peroxiredoxins), which have two. although it is more similar to 2-cys orthologs, mhprx can still function with a single peroxidatic c ... | 2017 | 27858147 |
| relationship between expression of interleukin-5 and interleukin-13 by epithelial cells and bronchiolar changes in pigs infected with mycoplasma hyopneumoniae. | mycoplasma hyopneumoniae (mh) is a bacterium that specifically infects the surface of bronchi and bronchioles of pigs without invading the host cells, and it is considered to be the primary agent of porcine enzootic pneumonia (pen). the present study investigates the morphological and immunohistological changes induced in bronchiolar epithelium by mh infection. lungs from 20 pigs with naturally occurring mh pneumonia were compared with those from 10 uninfected controls. bronchiolar epithelial he ... | 2017 | 26922858 |
| assessment of mycoplasma hyopneumoniae-induced pneumonia using different lung lesion scoring systems: a comparative review. | mycoplasma hyopneumoniae is the primary aetiological agent of swine enzootic pneumonia (ep) and one of the major contributors to the porcine respiratory disease complex (prdc). gross lung lesions in pigs affected by ep consist of cranioventral pulmonary consolidation (cvpc), usually distributed bilaterally in the apical, intermediate, accessory and cranial parts of the diaphragmatic lobes. several lung scoring methods are currently in place for the evaluation of cvpc. the aims of this study were ... | 2017 | 26774274 |
| low temperature and dust favour in vitro survival of mycoplasma hyopneumoniae: time to revisit indirect transmission in pig housing. | porcine enzootic pneumonia (ep) caused by mycoplasma hyopneumoniae adversely affects pig welfare and is associated with major economic losses in the pig industry worldwide. transmission is predominantly by direct contact, but the role of indirect transmission remains poorly understood. this study examined survival of six m. hyopneumoniae isolates dried onto five different surfaces encountered in pig units and exposed to temperatures of 4, 25 and 37°c for up to 12 days. survival of the organisms ... | 2017 | 27759918 |
| the use of oral fluids to monitor key pathogens in porcine respiratory disease complex. | the usefulness of oral fluid (of) sampling for surveillance of infections in pig populations is already accepted but its value as a tool to support investigations of porcine respiratory disease complex (prdc) has been less well studied. this study set out to describe detection patterns of porcine reproductive and respiratory syndrome virus (prrsv), porcine circovirus type 2 (pcv2), swine influenza virus type a (siv) and mycoplasma hyopneumoniae (m. hyo) among farms showing differing severity of ... | 2017 | 28405463 |
| etiology of acute respiratory disease in fattening pigs in finland. | the objective of our study was to clinically and etiologically investigate acute outbreaks of respiratory disease in finland. our study also aimed to evaluate the clinical use of various methods in diagnosing respiratory infections under field conditions and to describe the antimicrobial resistance profile of the main bacterial pathogen(s) found during the study. | 2017 | 28852568 |