Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the reversal of surgically induced reticuloendothelial depression. | the function of the reticuloendothelial (re) system may be depressed by surgical operation. as this system is an important defence mechanism against tumour growth and metastasis, it would be an advantage if this depression could be prevented by the administration of a suitable agent. the agents studied in this case were levamisole, corynebacterium parvum (c. parvum) and glucan. as a measure of re function a carbon clearance test was performed in rats, 1 hr after partial colectomy, animals having ... | 1979 | 487654 |
| immunotherapy of a murine ovarian carcinoma with corynebacterium parvum and specific heteroantiserum. i. activation of peritoneal cells to mediate antibody-dependent cytotoxicity. | immunotherapy with a combination of corynebacterium parvum and specific heteroantiserum is significantly more effective than treatment with either single agent in prolonging the survival of mice that have recevied an i.p. injection of syngeneic murine ovarian carcinoma (mot) cells. invitro, a combination of c. parvum-activated peritoneal cells and specific heteroantiserum has proven significantly more effective than either single component in destroying 51cr-labeled mot cells in the absence of c ... | 1979 | 489967 |
| chemoimmunotherapy for meningeal melanocytoma of the thoracic spinal cord. report of a case. | 1979 | 490860 | |
| anaerobic bacteria in late infections following orthopedic surgery. | twelve patients with late anaerobic infection following hip or knee arthroplasty or tibia osteosynthesis are presented. peptococci (peptococcus asaccharolyticus, p. magnus, p. prevotii) and peptostreptococci (peptostreptococcus micros, p. anaerobius, p. parvulus) were present in nine of the cases. anaerobic gram-positive or -negative rods were found in three cases (propionibacterium acnes, actinomyces israelii, and bacteroides fragilis). antibodies against the isolated bacteria were detected in ... | 1979 | 492071 |
| pharmacokinetics of phenytoin and liver cytochrome p-450 levels in mice after single doses of corynebacterium parvum [proceedings]. | 1979 | 497584 | |
| comparative antitumor effects of corynebacterium parvum, bordetella pertussis, bacillus calmette-guérin, and levamisole alone or in combination with cyclophosphamide in the cad2 murine mammary adenocarcinoma system. | the antitumor efficacy of various immune stimulants [corynebacterium parvum, bordetella pertussis, and bacillus calmette-guérin (bcg)] and levamisole alone or in conjunction with cyclophosphamide (cy) was studied in the cad2 mammary adenocarcinoma system using schedules developed previously with c. parvum and cy. weekly systemic treatment with c. parvum, b. pertussis, or bcg was effective in controlling tumor growth and had equivalent antitumor effects, but weekly treatment (or a single treatmen ... | 1979 | 498111 |
| surgery plus corynebacterium parvum immunotherapy for lewis lung carcinoma in mice. | 1979 | 499275 | |
| effects of whole body irradiation in mice treated with c. parvum. | 1979 | 499277 | |
| lung cancer patients treated with corynebacterium parvum. phase i toxicity study. | 1979 | 503003 | |
| effect of corynebacterium parvum in prevention and reversal of atrophy of the liver following portacaval shunt. | since it has been demonstrated that the administration of corynebacterium parvum is associated with increased hepatocyte proliferation in both normal and regenerating livers, it seemed appropriate to determine whether the use of this agent would affect the hepatic atrophy which occurs following end-to-side portacaval shunts. when administered at shunting, liver weight and liver deoxyribonucleic acid failed to decrease to the same extent as that occurring in untreated, shunted rats. an increase i ... | 1979 | 462347 |
| [adriamycin-combination chemotherapy with or without immune stimulation by corynebacterium parvum in metastasizing carcinoma of the breast (author's transl)]. | in a randomised, multicentre study the effect of changing the combined cytostatic treatment with vac (vincristin, adriamycin, cyclophosphamide) to fmc (fluorouracil, methotrexate, cyclophosphamide) was tested, as well as the effect of active non-specific immune stimulation with corynebacterium parvum, and compared with a control group. in 59 of 120 patients (49%) in whom the results could be analysed there was a measurable significant regression of tumour size to less than 50% of its initial val ... | 1979 | 510206 |
| investigations on the bacteriostatic effect of benzoyl peroxide. | 1979 | 464656 | |
| [effect of corynebacterium parvum on serum lysozyme (muramidase) levels (author's transl)]. | an i.v. injection of 548 microgram of killed corynebacterium parvum into c57b1 mice leads to significant changes in serum lysozyme (muramidase) levels. after an initial fall at 24 h, the activity of the enzyme increased progressively, reached a peak on the 9th day and returned to control range after the 15th day. | 1979 | 477851 |
| comparison of the in-vitro antitumor activity of peritoneal cells from mice injected with corynebacterium parvum and corynebacterium liquefaciens. | 1979 | 478988 | |
| is there postdefecation bacteremia? | an investigation was done to determine the incidence of postdefecation bacteremia. a study of 82 healthy volunteers was done. among 164 predefecation cultures, only one (0.6%) from an anaerobic flask was positive for microorganism, which was identified as staphylococcus epidermidis. in only two of 328 (0.6%) postdefecation cultures did microorganisms grow, which were shown to be propionibacterium acnes. the results of this study suggest that either bacteremia after defecation does not occur or i ... | 1979 | 464809 |
| regression of regionally advanced melanoma after arterial infusion with cis-platinum and actinomycin-d. | 1979 | 466896 | |
| choriogonadotropin-like antigen in an anaerobic bacterium, eubacterium lentum, isolated from a rectal tumor. | using the indirect fluorescein-labeled and indirect peroxidase-antiperoxidase-labeled immunohistochemical techniques, and utilizing both antiserum specific for the beta-subunit of choriogonadotropin and antiserum for the total hormone, we have demonstrated the presence of a choriogonadotropin-like immunoreactive material in a strain of eubacterium lenthum that was originally isolated from a rectal tumor. in contrast, both immunohistochemical reactions were negative when applied to a strain of co ... | 1979 | 468380 |
| [equal sensitivity of normal or tumoral fibroblasts to cytotoxic and cytostatic effects of normal or "corynebacterium parvum" activated peritoneal exudate cells (author's transl)]. | cytotoxic and cytostatic properties of peritoneal exudate cells from balb/c mice either normal or pretreated with corynebacterium parvum normal were studied using as target cells two lines of balb/c fibroblasts one normal (balb) and one transformed by kirsten virus (k.balb).. c. parvum activated cells displayed higher cytotoxic as measured by 51cr or 3h-thymidine release and cytostatic, as measured by 3h-thymidine incorporation, activities against these lines of syngeneic cells. cytotoxic effect ... | 1979 | 475346 |
| non-specific and specific active immunotherapy in a b16 murine melanoma system. | conflicts amongst reports concerning the efficacy of both nonspecific and specific attempts at immunotherapy may be ascribed to different animal models utilizing tumors of different immunogenicity. we have selected the b16 mouse melanoma model as the example of a spontaneously occurring neoplasm that is histocompatible with the host and does have tumor-associated antigens. attempts to alter tumor growth or survival with nonspecific active immunotherapy as well as with specific active immunothera ... | 1979 | 480953 |
| growth of cutaneous propionibacteria on synthetic medium; growth yields and exoenzyme production. | 1979 | 541303 | |
| prolonged effect of corynebacterium parvum stimulation on granulopoiesis. | an intravenous injection of 548 microgram of killed corynebacterium parvum (c. parvum) into c57bl mice led to a significant increase in the number of both committed stem cells (gm-cfc) and proliferating cells of bone marrow granulocytic series. this increase appeared 24 h after the injection of the bacterium, persisted in varying levels until the 4th week and was accompanied by a marked and prolonged granulocytosis. the proportion of gm-cfc in dna synthesis was found to be increased 1, 2, and 5 ... | 1979 | 542797 |
| comparison of three methods of susceptibility testing of bacteroidaceae, peptococcaceae and other anaerobes to doxycycline. | the in vitro activity of doxycycline against 147 strains of gram-positive and gram-negative anaerobes was determined by broth dilution, agar dilution and agar diffusion tests. the strains were isolated from clinical specimens in 1977. saccharolytic bacteroides strains (39 b. fragilis, 6 b. thetaiotaomicron, 4 b. vulgatus) showed broth dilution mics of less than or equal to 0.0625-4.0 microgram/ml after 5 h incubation and mics of less than or equal to 16 microgram/ml after 15 h incubation at 37 d ... | 1979 | 543353 |
| an ultrastructural study of peritoneal mononuclear phagocytes from corynebacterium parvum-injected mice. | peritoneal mononuclear phagocytes harvested from mice 24 h after i.p. injection of c. parvum displayed hypertrophy of the golgi and smooth endoplasmic reticulum complex with attendant increase in lysosome production. the ingested bacilli were identified within phagolysosomes, within which large myelin figures accumulated. in addition to heterophagic vacuoles, autophagosomes and lipid droplets were observed. these latter two inclusions may reflect a direct or indirect cytopathic effect of c. parv ... | 1979 | 475974 |
| monocytes and macrophages in malignant melanoma iv. effects of c. parvum on monocyte function. | assays for the capacity of peripheral-blood monocytes (a) to mature in vitro into macrophages, (b) to reduce nitro-blue tetrazolium (nbt) and (c) to lyse antibody-coated human group a red cells, were applied to a group of 82 patients with histologically proven malignant melanoma. in patients with micrometastatic disease there was an enhancement of red-cell lysis and nbt reduction, suggesting that their monocytes are in some way "activated", whereas nbt reduction was suppressed in those with over ... | 1979 | 486312 |
| lack of effect of immunotherapy with bcg and corynebacterium parvum on hepatic drug hydroxylation in man. | serial serum diphenylhydantoin and urinary 5-(p-hydroxphenyl)-5-phenylhydantoin concentrations were determined in 8 patients with malignant disease and 4 healthy volunteers on 2 separate occasions after an oral dose of diphenylhydantoin (500 mg). no significant difference was observed between metabolism before and 10 days after immunization with bcg or corynebacterium parvum. volunteers without intervening immunization similarly showed no difference. | 1979 | 444399 |
| [in vitro sensitivity of corynebacterium acnes (propionibacterium acnes) to meclocycline, clindamycin, erythromycin and neomycin]. | 1979 | 554810 | |
| chemoimmunotherapy in the management of primary stage iii ovarian cancer: a gynecologic oncology group study. | the effectiveness of chemoimmunotherapy was evaluated in 45 previously untreated stage iii ovarian cancer patients. response rate, progression-free interval, and survival were considerably better than in a similar group of 63 patients treated with a single alkylating agent alone. | 1979 | 445505 |
| positive correlation between the levels of natural killer cells and the in vivo resistance to syngeneic tumor transplants as influenced by various routes of administration of corynebacterium parvum bacteria. | 1979 | 455483 | |
| macrophage activation and increased resistance to infection in immunosuppressed mice treated with corynebacterium parvum vaccine or pyran copolymer. | 1979 | 458782 | |
| the effect of bcg-vaccination on vaccinia virus infections in mice. | pretreatment with bcg yielded a high degree of protection against experimental vaccinia virus infections in mice. corynebacterium parvum and aristolochia acid were less protective; other immunostimulants were ineffective. | 1979 | 389657 |
| the effect of acidic polysaccharides and prostaglandin-like substances isolated from propionibacterium acnes on granulocyte chemotaxis. | three acidic polysaccharide (ap) fractions and the prostaglandin-like substances (pls) isolated from p. acnes were investigated regarding their chemotactic activities on polymorphonuclear leukocytes. both ap's and pls induced a significant chemotatic response, which suggests their involvement in inflammatory acne vulgaris. | 1979 | 391585 |
| subcutaneous corynebacterium parvum in bladder cancer: a controlled study of its immunological effects. | fourteen out of 26 patients with invasive bladder cancer were randomly assigned to receive weekly subcutaneous injections of corynebacterium parvum (cp) in addition to standard treatment. peripheral blood t lymphocyte percentage, k cell activity, mitogen responsiveness, and monocyte and polymorph leucotaxis were measured at intervals over a period of 1 to 2 years. the only consistent difference between the cp-treatment patients and the controls was a slightly higher level of k cell activity in t ... | 1979 | 380732 |
| cyclophosphamide plus 5-(3,3-dimethyl-1-triazeno)-imidazole-4-carboxamide (dtic) with or without corynebacterium parvum in metastatic malignant melanoma. | one hundred twenty patients with metastatic malignant melanoma were randomized to receive either cyclophosphamide, 600 mg/m2 iv, on day 1 plus dtic 200 mg/m2 iv days 1 through 5, or the same chemotherapy plus c. parvum 5 mg/m2 iv on day 8 and day 15. therapy was repeated every 21 days. although responses were observed in 13.8% of patients on cyclophosphamide plus dtic versus 25.5% of patients on cyclophosphamide plus dtic plus c. parvum, the median duration of remission was 15.6 weeks on chemoth ... | 1979 | 383276 |
| c. parvum treatment of transplanted rat tumours of spontaneous origin. | c. parvum (wellcome cn6134) has been examined for suppression of a range of transplanted rat tumours of spontaneous origin. with five tumours (three mammary carcinomas and two fibrosarcomas) growth of comparatively high cell inocula (with respect to the minimum for growth in control rats) was suppressed by admixture with the vaccine. equivalent dry weights of glaxo, pasteur or connaught bcgs were relatively ineffective. intralesional injection of c. parvum into three three established tumours (t ... | 1979 | 385514 |
| direct effects of corynebacterium parvum and bcg on human monocyte-mediated tumour cell cytostasis in vitro. | four strains of corynebacterium parvum (cp) and bcg induced low levels of cytostatic ability to a human tumour cell line in human monocytes when added directly to conventional monocyte cultures. the cytostatic ability induced by mediators from autologous lymphocytes stimulated with the same agents was greater than that produced by direct addition to monocytes. bcg was more efficient in stimulating lymphocyte dna-synthesis and lymphokine release than any of the cp strains tested. in order to test ... | 1979 | 386712 |
| prostaglandin-like substances in propionibacterium acnes. iii. differential contractile effects on smooth muscle layers of the human utero-tubal junction. | the biological activity of a lipid fraction extracted from p. acnes was tested on isolated smooth muscle strips from the human utero-tubal junction. the bioassay experiments support the concept that prostaglandin-like substances (pls) occur in p. acnes. however, in the bioassay system used, the effect of pls was different from that of pgf2 alpha and pgi2 but similar, although not identical, to that of arachidonic acid and pge2. | 1979 | 387431 |
| immunotherapy of lung cancer. i. review of clinical trials in non-small cell histologic types. | 1979 | 394836 | |
| antitumor activity of cell-wall skeleton of propionibacterium acnes c7 in mice and guinea pigs. | the antitumor activity of the cell-wall skeleton (cws) of propionibacterium acnes c7 was examined by using transplantable tumors in syngeneic mice and in guinea pigs, and autochthonous tumors in mice. p. acnes-cws was shown to suppress the growth of fibrosarcomas, el4 leukemia, and mh134 hepatoma in syngeneic mice, and to regress the established tumors of a fibrosarcoma (mc104) in c57bl/6j mice, and a hepatoma (line-10) in strain-2 guinea pigs. the oil-attached p. acnes-cws mixed with fructose m ... | 1979 | 395008 |
| human monocyte-mediated cytotoxicity to k-562 cells: activation by lymphokines. | human monocytes purified by adherence and prolonged in vitro monolayer culture were activated by supernatants of autologous lymphocytes stimulated with live bacillus calmette-guérin or killed corynebacterium parvum. activated monocytes expressed increased ability to lyse k-562 cells prelabelled with methyl-3h-thymidine in a 48 h assay. activation could be detected at a 1:64 dilution of lymphokine supernatants. target cell killing by activated monocytes was strongly influenced by the density of t ... | 1979 | 396667 |
| influence of tumor burden, tumor removal, immune stimulation, plasmapheresis on monocyte mobilization in cancer patients. | 1979 | 397757 | |
| radiation-induced osteogenic sarcoma of c3h mouse: effects of corynebacterium parvum and wbi on its natural history and response to irradiation. | 1979 | 285860 | |
| phagosome/lysosome fusion: a possible prerequisite for the enhancement of antibody responses in vitro by bcg, mycobacterium leprae and corynebacterium parvum. | primary in vitro antibody responses to srbc were suppressed in cultures prepared from the spleens of cba mice injected i.v. 20 days previously with 10(8) liver bcg. in contrast, cultures prepared from mice injected with dead bcg showed enhanced responses. in vitro spleen cell responses of the mice had returned to normal levels 4--6 weeks after their injection, but if dead bcg, m. leprae or c. parvum was added to the cultures, responses were enhanced. the enhancing effect of the added bacteria co ... | 1979 | 399339 |
| separation of functionally distinct subpopulations of corynebacterium parvum-activated macrophages with predominantly stimulatory or suppressive effect on the cell-mediated cytotoxic t cell response. | 1979 | 312146 | |
| antigenic bacterial polysaccharide in rheumatoid synovial effusions. | phenol-water extracted rheumatoid synovial fluids and synovial fluid leukocytes contain an antigen immunologically identical to the proprionibacterium group bacteria. the antigen was identified by counter-immunoelectrophoresis in 70% of rheumatoid synovial fluid leukocyte pellets and in 60% of rheumatoid synovial fluids. it was also present in 6% of nonrheumatoid fluids and in 22% of nonrheumatoid inflammatory fluid leukocytes. antigen was not detectable in synovial samples before extraction. sy ... | 1979 | 314293 |
| effects of repeated corynebacterium parvum and bcg therapy on immune parameters: a weekly sequential study of melanoma patients. i. changes in non-specific (nk, k and t cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions. | increased lymphocyte cytotoxicity, particularly of 'killer' k cell type was recorded with repeated immunizations of either c. parvum or bcg. a 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. no marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. expression of cytotoxicity results as percentage 51cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymp ... | 1979 | 314367 |
| value of immune monitoring in gynecologic cancer patients receiving immunotherapy. | immunotherapy with nonspecific immunopotentiators such as corynebacterium parvum is under study in several areas of gynecologic oncology. the efficacy of this new modality awaits the results of carefully done clinical trials designed to measure an improved effect on survival when this and similar agents are added to conventional therapy. this report deals with an attempt to demonstrate enhancement of the cell-mediated immune response in a small number of patients with advanced ovarian (18 patien ... | 1979 | 315714 |
| effect of corynebacterium parvum on liver proliferation and regeneration. | 1979 | 421219 | |
| the aerobic growth of propionibacterium acnes in primary cultures from skin. | although propionibacterium acnes ordinarily grows as an anaerobe, this organism was commonly seen on aerobic primary cultures (directly from skin) of the forehead, axilla, deltoid area, and antecubital fossa. on subculture, strains from aerobic primary cultures showed their normal anaerobic state. on repeated tests of the foreheads of 7 subjects over periods of 1 to 4 yr, 24% of all cultures were positive for propionibacteria (p. acnes) on aerobic culture. this phenomenon was equally common in c ... | 1979 | 422866 |
| conditions for effective bacillus calmette-guérin immunotherapy of postsurgical metastases of 13762a rat mammary adenocarcinoma. | we evaluated critical variables in bacillus calmette-guérin (bcg) immunotherapy of residual 13762a rat mammary adenocarcinoma. bcg was given intratumorally on day 7 of tumor growth and followed by primary tumor excisions on day 20. untreated animals died on about day 40 with axillary nodal and pulmonary parenchymal metastases. bcg-treated animals experienced prolonged survival, and some were cured. the highest dose (5.0 x 10(7) colony-forming units) of bcg was more effective than the lowest (0.5 ... | 1979 | 427785 |
| effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma a sequential study over 28 days. i. changes in blood counts, serum immunoglobulins and lymphoid cell populations. | the effects of a single immunization of melanoma patients with bcg or c. parvum on the blood counts, serum immunoglobulin levels and lymphoid subpopulations were followed by multiple assays over 28 days. c. parvum produced a decrease in the white cell count, lymphocyte count and lymphoid t and sig+ cell numbers, which recovered within 1 week; bcg did not produce such a marked depression. both agents were associated with increases in t cell numbers and lymphocyte pha blastogenesis after the first ... | 1979 | 428146 |
| fatal infection with pseudomonas aeruginosa in mice treated with cyclophosphamide and propionibacterium acnes. | 1979 | 428451 | |
| effect of corynebacterium parvum on hemopoietic stem-cell kinetics. | the intravenous administration of 548 microgram of killed corynebacterium parvum (c. parvum) into c57bl mice leads to a significant decrease in the number of bone-marrow colony-forming-units in spleen (cfus) as early as 12 h after the injection of the bacterium. this decrease persisted in varying degrees for 3 weeks. after an initial fall at 24 h, the splenic cfus exhibited a rapid expansion and reached values 10 times higher than the control range on the ninth day. a significant rise in the num ... | 1979 | 759377 |
| selective antibacterial action of 2-mercaptoethanol on propionibacteria in skin cultures. | 2-mercaptoethanol applied to the surface of agar medium had a selective antibacterial effect on propionibacterium acnes and propionibacterium granulosum without interfering with the growth of peptococcus saccharolyticus or staphylococci in anaerobic cultures of skin or in pure cultures. in aerobic broth culture, 2-mercaptoethanol inhibited aerobes and stimulated anaerobes, consistent with its action as a reducing agent. | 1979 | 760636 |
| effect of adriamycin and corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells. | administration of adriamycin and corynebacterium parvum alone in c57bl/6j mice bearing lewis lung carcinoma stimulated the direct (19s) and indirect (7s) plaque-forming cell (pfc) response specific for sheep red blood cells. thus adriamycin appears to possess some immunostimulatory effect on tumor-bearing mice with much less effect than c. parvum alone. simultaneous administration of adriamycin and c. parvum decreased the pfc response compared to that for c. parvum alone. this decrease may indic ... | 1979 | 379400 |
| corynebacterium parvum: effects on the biochemistry of mouse serum and liver. | 1979 | 379402 | |
| chemoimmunotherapy (dtic and corynebacterium parvum) as adjuvant treatment in malignant melanoma. | sixty-one patients with stage i or ii (lymph node involvement) malignant melanoma were prospectively randomized into a control group receiving surgical treatment only (consisting of wide excision of primary and regional node dissection) and a group receiving the same surgical treatment plus adjuvant therapy with dtic and corynebacterium parvum. followup times ranged from 1 1/2 to 4 years. among the 29 patients in the surgical control group, there were five hematogenous recurrences and one region ... | 1979 | 393377 |
| inhibition of spontaneous akr leukemia by multiple inoculations of corynebacterium parvum. | in previous studies we have shown that akr mice could be protected from spontaneous leukemia by specific immunotherapy in combination with splenectomy. in this experiment we investigated the effects of nonspecific immunotherapy with c. parvum in a similar regimen. it was found that bi-weekly, ip inoculations of 0.7 mg of c. parvum could significantly protect akr mice from spontaneous tumors, and that splenectomy could not modify this effect. thus, the spleen does not appear to play a determinant ... | 1979 | 476565 |
| sensitivity to chemotherapeutic and immunomodulating agents of two mouse lymphomas and of a macrophage tumor. | the effect of treatment with 15 chemotherapeutic and 10 immunomodulating agents on the growth of t-cell lymphoma el-4, macrophage tumor j774, and b-cell lymphoma 70z/2 of the mouse has been studied using the prolongation of median survival time of tumor-bearing hosts as an index of therapeutic effectiveness. the survival time of mice bearing 70z/2 was prolonged more than 100% by single-agent therapy with actinomycin d, cyclophosphamide, 6-mercaptopurine, mitomycin c, and vinblastine; a similar r ... | 1979 | 476634 |
| effect of 1(4-amino-2-methyl-5-pyrimidinyl) methyl-3-(2-chloroethyl)-3-nitrosourea hydrochloride (acnu) on sato lung carcinoma (slc). preliminary result of immunochemotherapy for slc by combination of acnu and propionibacterium acnes. | acnu was highly effective for sato lung carcinoma transplanted intravenously or intramuscularly by using a large single dose, and the cytotoxic action of acnu for slc showed clear dependence upon tumor size. nonspecific activation of host-defence mechanism by propionibacterium acnes contributed to the suppression for the regrowth of solid slc treated by acnu. | 1979 | 450390 |
| effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma. a sequential study over 28 days. ii. changes in non-specific (nk, k and t cell) lymphocytoxicity and delayed hypersensitivity skin reactions. | c. parvum and bcg produced significant changes in nk, k and t cell lymphocytotoxicity using a chang liver target cell. a consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. this was particularly marked for c. parvum and 'k' cell activity. skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. the importance of using lymphocyte concentration-cytotoxicity titration curves a ... | 1979 | 312169 |
| response of lympho-hemopoietic tissue to corynebacterium parvum by study of dna enzymes and h3-tdr metabolism. | the effects of corynebacterium parvum on the lymphohemopoietic tissues of mice was investigated by h3-tdr metabolism, organ weights, dna-polymerase-alpha activity and terminal deoxynucleotidyl transferase (tdt) activity. marked increase in spleen size occurred. the increase in size was accompanied by increases in dna-p-alpha activity and h3tdr uptake. this indicated that the spleen was a major site of cell proliferation and of increase in population size after c. parvum stimulation. thymus and b ... | 1979 | 317898 |
| [prospects of short-term sequential immunomodulation with levamisole and corynebacterium parvum in neoplastic pathology in the aged]. | 1979 | 460632 | |
| metabolic changes following the intravenous infusion of corynebacterium parvum in man. | the acute changes in concentrations of key blood metabolites and liver function tests were measured following intravenous infusion of corynebacterium parvum in 9 healthy patients who had recently undergone resection of a colorectal cancer. the following results were obtained: 1) blood glucose, lactate and ketone body concentrations significantly increased over a 5 hour study period; 2) blood alanine fell during the same period; 3) plasma bilirubin, got and urea were significantly elevated 24 hou ... | 1979 | 445333 |
| immunotherapeutic response of concanavalin a-bound l1210 vaccine enhanced by a streptococcal immunopotentiator, ok-432. | immunotherapeutic response to concanavalin a (con a)-bound l1210 murine leukemic vaccine and immunopotentiators was examined in histocompatible animals bearing a small burden l1210 leukemic cells. when combined with con a-bound vaccine, a streptococcal immunopotentiator, ok-432 (nsc b116209), prepared from streptococcus pyogenes, was potent in antitumor therapy and resulted in a number of cured animals. administration of either con-a-bound vaccine or ok-432 alone did not produce any beneficial e ... | 1979 | 445486 |
| aerobic and anaerobic bacterial flora of the maternal cervix and newborn gastric fluid and conjunctiva: a prospective study. | aerobic and anaerobic cultures were performed on cervical swabs from 35 mothers and their newborn infants' gastric aspirates and conjunctival sacs. four hundred seventy-nine isolates were obtained; 287 were aerobes and 192 were anaerobes. the cervical and gastric cultures overall yielded a similar flora, but this was not always the case when one compared mothers with their own newborn infants. the conjunctival cultures yielded about half of the number of bacteria per specimen that the gastric co ... | 1979 | 440845 |
| [porphyrin production of propionibacterium acnes]. | 1979 | 442749 | |
| chemical and biological properties of a purified lymphoreticular-stimulating fraction of corynebacterium parvum (propionibacterium acnes type i). | a method is described in which washed whole cells of corynebacterium parvum were chemically and enzymatically extracted to remove cytoplasm and cell-wall lipids. the resultant insoluble cell-wall residue possessed lympho-reticular stimulating properties as measured by their ability to increase spleen weight and protect against tumour-cell challenge. analysis of the final product by chromatography and infrared spectroscopy has shown it to consist of carbohydrate and peptidoglycan, both of which a ... | 1979 | 513108 |
| the facilitation of tumour growth in the lung by cyclophosphamide in artificial and spontaneous metastases models. | 1979 | 527634 | |
| active, specific immunotherapy of murine leukemia. ii. adjuvant effect of corynebacterium parvum. | we have previously shown that irradiated lstra cells (lx) were immunogenic and could prolong survival of mice bearing lstra tumors. this study demonstrated that addition of corynebacterium parvum to the lx dramatically improved the strength of tumor immunity. in pretreatment-challenge experiments, c. parvum augmented the immunogenicity of 10(6) lx given intradermally, with an optimum dose of 0.14-1.4 microgram c. parvum per mouse. in therapy experiments (intraperitoneal vaccine treatment after t ... | 1979 | 528079 |
| action of cancer chemotherapy-radiotherapy on spleen hypertrophy response to corynebacterium parvum adjuvant therapy. | 1979 | 536279 | |
| biotyping of propionibacterium acnes isolated from normal human facial skin. | biochemical and serological characteristics of 128 strains of propionibacterium acnes isolated from the facial skin of healthy japanese volunteers were compared with the three standard strains of the american type culture collection, atcc 6919, 11827, and 11828. accordingly, the isolated strains of p. acnes were classified into five biotypes (b1 to b5) on the basis of fermentation tests of ribose, erythritol, and sorbitol. two serotypes were distinguished by the agglutination test. p. acnes belo ... | 1979 | 539817 |
| effects of intravenous injection of two different strains of corynebacterium parvum in the mouse. | a strain of c. parvum, cn6134, known to have antitumour activity, caused thrombosis in the sites where the organism is phagocytosed. it bound to macrophages in vitro and activated the alternate pathway of complement. a strain of c. parvum, cn5888, which fails to show antitumour activity, did not show thrombosis. it did not bind to macrophages or activate guinea-pig complement. it did, however, cause marrow infarction which seems to result from a diminished clearance of the organism from the circ ... | 1979 | 540104 |
| protection of mice against endotoxin-induced liver damage by anti-inflammatory drugs. | mice were injected with corynebacterium parvum, which induces multiple granulomas in liver and renders animals hyper-reactive to the lethal effect of bacterial lipopolysaccharide (lps). such animals when challenged with lps developed also extensive liver parenchymal cell damage as estimated by elevated blood asparate transaminase levels and a hypoglycaemia. treatment with indomethacin, hydrocortisone, dexamethasone, promethazine, metiazinic acid and (+)-catechin ameliorated the liver damage. hyd ... | 1979 | 546179 |
| activation of pleural macrophages by intrapleural application of corynebacterium parvum. | a single ipl injection of 0.25 mg cp into cba mice led to accumulation of macrophages in the pleural cavity, but it did not influence res as an injection given iv ipl cp caused a three-to-five-fold increase in the number of nucleated cells in the pleural cavity which persisted at least 14 days. of these cells 86% were macrophages as shown by their esterase activity. less than 30% of cells from the pleural cavity of normal mice were esterase positive. macrophages from the pleural cavity of cp-tre ... | 1979 | 547729 |
| role of mononuclear phagocytes in decreased hepatic drug metabolism following administration of corynebacterium parvum. | 1979 | 551956 | |
| [postoperative prevention of recurrence with intrapleural corynebacterium parvum in patients with stage i and ii bronchial carcinomas. ludwig lung cancer study i]. | the ludwig lung cancer group was created in 1977. participants are from austria, denmark, germany, norway, sweden, switzerland, and yugoslavia. 400 patients are randomized yearly. the clinical trial i investigating the role of c. parvum intrapleurally as adjuvant therapy in operable non-small cell lung cancer patients has been closed in february 1979 with a total accrual of 475 patients. the average follow-up time for these cases is approximately 8 months. it is early to make any definitive comp ... | 1979 | 462160 |
| effects of repeated corynebacterium parvum and bcg therapy on immune parameters: a weekly study of melanoma patients ii. changes in serum immunoglobulins and lymphoid cell subpopulations. | two groups, each of eight patients, with metastatic melanoma were immunized with either c. parvum or bcg at 3-weekly intervals. the serum igg, iga, igm levels, e-rosettes, ea-rosetts, sig-bearing cells, 'null cells' and lymphocyte blastogenesis at four pha concentrations were assayed, before immunization and weekly thereafter for 8 weeks. the pre-immunization e-rosette values were significantly reduced, with a significant increase in 'null cell' values and ea-rosette percentages, when compared w ... | 1979 | 487647 |
| host treatments affecting artificial pulmonary metastases: interpretation of loss of radioactively labelled cells from lungs. | the effect has been examined of various host treatments (c. parvum injection, immunization, thoracic irradiation, cyclophosphamide injection, and anticoagulation) on both lung colony formation and clearance of radioactive cells from the lungs after i.v. injection of tumour cells. two tumour-host models have been used: the non-immunogenic kht tumour in c3h/km mice, and the immunogenic emt6 tumour in balb/c/ka mice. even for the at most weakly immunogenic kht tumour, the number of artificial pulmo ... | 1979 | 508577 |
| macrophage precursors in ovarian carcinoma. | 1979 | 510998 | |
| alterations induced in macrophage and granulocyte-macrophage colony-forming cells by a single injection of mice with corynebacterium parvum. | 1979 | 513059 | |
| enhancement of the thermal response of animal tumors by corynebacterium parvum. | the effect of corynecbacterium parvum treatment on the thermal response of animal tumors was studied. tumors were methylcholanthrene-induced (fsa-ii) and spontaneous (fsa-i) fibrosarcomas in c3hf/sed mice. c. parvum was given i.v. and was followed by local hyperthermia at 43.5 degrees 3 days later. cell survival determined by lung colony assays showed that preadministration of c. parvum insignificantly enhanced the thermal response of both tumors. studies of delay of tumor growth for fsa-ii demo ... | 1979 | 476675 |
| quantitative and functional differences induced in bone marrow-derived mononuclear phagocytes by inflammatory stimuli. | 1979 | 458783 | |
| effects of dose and schedule of immune stimulant on efficacy of combination corynebacterium parvum-cyclophosphamide treatment for a murine mammary adenocarcinoma. | certain variables which might influence the outcome of combining cytotoxic drug and immune stimulant therapy were studied to optimize the effectiveness of corynebacterium parvum combined with cyclophosphamide (cy) as treatment for a murine mammary adenocarcinoma (cad2). optimal effects of combined c. parvum-cy treatment in the cad2 system were obtained when 443 to 1400 microgram of this immune stimulant per mouse were injected 2 to 3 days after cy chemotherapy and when combination treatment was ... | 1979 | 761179 |
| do anaerobes cause urinary tract infection? | 1980 | 6101823 | |
| autoantibodies in cancer patients given corynebacterium parvum/levamisole immunotherapy. | 1980 | 6103412 | |
| haemagglutinating activity of propionibacterium acnes isolated from the human oral cavity. | 1980 | 6110490 | |
| propionibacterium acnes infection complicating craniotomy. | 1980 | 6182220 | |
| immunomodulation by corynebacterium parvum in normal humans. | four normal human donors were immunized with 2 mg of heat-killed corynebacterium parvum by subcutaneous and intracutaneous injections, and lymphocyte surface markers, antibody-dependent (adcc), and spontaneous cell-mediated (scmc) cytotoxicities followed for a 28-day period. although no changes were observed in the relative proportions of b, t, and fc receptor-carrying lymphocytes, two t cell subpopulations, namely, the autologous rosette-forming cells and active rosette-forming cells, both exhi ... | 1980 | 6154095 |
| tumor-immunotherapeutic efficacy of serratia marcescens polyribosomes. | the ability of polyribosomes, obtained from several bacterial species, to suppress the development of cutaneous sad2 fibrosarcomas in dba/2 mice were evaluated. suppression of tumor appearance depended upon the tumor load at the time of treatment, dose of polyribosomes, and species source of polyribosomes, with serratia marcescens being superior to escherichia coli, streptococcus pneumoniae, mycobacterium bovis (pasteur), mycobacterium smegmatis, and propionibacterium acnes (formerly corynebacte ... | 1980 | 6154530 |
| immunostimulation and host resistance against infection: therapeutic perspectives. | 1980 | 6157316 | |
| species-restricted effects of human and mouse lymphokines on macrophages. | lymphokines produced by antigenic or mitogenic stimulation of human, guinea pig and mouse lymphocytes were tested for their effects on monocytes or macrophages of the same and heterologous species, to determine whether there is any species restriction in their reactivity. supernatants from lymphocyte cultures were tested for migration inhibitory activity in an indirect agarose microdroplet assay and for their ability to augument cytolytic activity of macrophages or monocytes in a [3h]thymidine-r ... | 1980 | 6157542 |
| human peripheral null lymphocytes. ii. producers of type-1 interferon upon stimulation with tumor cells, herpes simplex virus and corynebacterium parvum. | human blood lymphocytes, exposed for 6 to 24 h in vitro to tumor cells (k 562, igr3, l1210), herpes simplex virus type 1 (hsv) or corynebacterium parvum (cp), produced high levels of anti-viral activity which was identified as type-1 interferon (if). in mixed lymphocyte tumor cell cultures (mltc), the generated type-1 if was definitely shown to originate from the lymphocytes and not from the tumor cells. supplementation of leukocyte cultures with 10% fetal calf serum instead 10% human ab serum h ... | 1980 | 6157543 |
| cancer immunology. | 1980 | 6157656 | |
| effective outpatient combination chemotherapy for advanced cancer of the head and neck. | forty-six patients with advanced cancer of the head and neck, 42 of whom had failed conventional radiotherapy or surgical excision, or both, were treated on an outpatient basis with a regimen consisting of bleomycin, methotrexate and cis-diamminedichloroplatinum ii. objective responses were noted in 29 patients, with eight having apparent complete remissions. the median duration of partial response was only five months, but the median duration of complete remission was 11 months. median survival ... | 1980 | 6159692 |
| immunotherapy and genitourinary neoplasia. | 1980 | 6161466 | |
| modulation of the rats' immune status by monoassociation with anaerobic bacteria. | the capacity of a pure culture of anaerobic intestinal bacteria to influence the host's cellular and humoral immune systems was investigated with germfree, monoassociated, and conventionally reared rats. monoassociation of germfree rats with bacteroides fragilis stimulated the production of serum gamma globulin, agglutinating antibodies, and an apparent igg (immunoelectrophoresis) band. a comparison of the in vitro blastogenic potential of lymphocytes (spleen cells and mesenteric lymph node cell ... | 1980 | 6161685 |
| effects of topical erythromycin on aerobic and anaerobic surface flora. | the contents of acne lesions from 30 men with inflammatory acne vulgaris, obtained before and at the conclusion of 4 weeks of topical 2% erythromycin therapy, were cultured on aerobic and anaerobic plates. sensitivity testing of cultures was performed with discs containing 50 mg erythromycin, in order to ascertain the prevalence of erythromycin-resistant strains of propionibacterium acnes and aerobic micrococci. the percentages of patients in whom erythromycin-resistant micrococci could be isola ... | 1980 | 6162344 |
| benzoyl peroxide. | the mode of action of benzoyl peroxide in acne is three-fold, i.e. sebostatic, comedolytic and inhibitory to p. acnes in-vivo. benzoyl peroxide is the topical treatment of choice in acne vulgaris. this agent is well tolerated by most patients. primary irritant dermatitis can be avoided by less frequent application and the true incidence of contact sensitivity is low. the gel preparation has achieved a high degree of cosmetic acceptability. a synergistic effect with retinoic acid can be demonstra ... | 1980 | 6162349 |
| [therapeutic use of immunostimulants against infections (author's transl)]. | 1980 | 6162607 | |
| interferon production by corynebacterium parvum and bcg-activated murine spleen macrophages. | macrophages were identified to be a major source of interferon produced in murine spleen cell cultures after intravenous injection of corynebacterium parvum (c. parvum), strain cn 6134 or bacille calmette guérin (bcg). another strain of c. parvum, cn 5888, which lacks res stimulating activity and adjuvant activity in vivo, was not effective when injected intravenously. protein synthesis was required for interferon activity to be produced and protein synthesis was also required for the antiviral ... | 1980 | 6162779 |