Publications

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[basic studies on the antibiotic activity of lysozyme. ii. combined effects with aminobenzyl penicillin]. 19684385885
identical initial steps during transformation for high and low efficiency markers in diplococcus pneumoniae. 19684385904
an erythromycin-resistant pneumococcus. 19684385911
d. pneumoniae. increased resistance to oxacillin and cloxacillin. 19684384016
studies on streptococcal bacteriophages. ii. adsorption studies on group a and group c streptococcal bacteriophages.evidence has been presented that group c bacteriophages differ as to their inactivating site on the streptococcal cell wall. while all three phages adsorb to isolated cell walls, only the c1 phage was inactivated by enzymatically prepared group-specific carbohydrate. none of the group c phages were inactivated by chemically extracted group-specific carbohydrate. in contrast, all virulent group a streptococcal bacteriophages adsorbed only to living group a streptococci. however, group a temperate ...19684384046
seasonal mucopurulent conjunctivitis. observations on epidemiology in rural areas in summer. 19684383989
in vitro antimicrobial activity and human pharmacology of cephaloglycin.serum and urine concentrations of cephaloglycin (an orally absorbed derivative of cephalosporin c) were determined in normal volunteers and in patients. the in vitro activity of cephaloglycin was also studied. all strains of group a streptococci (streptococcus pyogenes) and diplococcus pneumoniae were inhibited by 0.4 mug of cephaloglycin per ml. eighty per cent of the staphylococcus aureus strains and about 50% of the escherichia coli and proteus mirabilis strains were inhibited by 1.6 mug of c ...19684385749
[the effect of diplococcal vaccine on the protein composition of the blood serum of pregnant cows and their calves]. 19684385462
predicted and unpredicted cross-reactions of an acetylphosphogalactan of sporobolomyces yeast.the teichoic acid of streptococcal group n, with end groups of galactose phosphate, had been shown to cross-react with antipneumococcal sera of types vi, xiv, xvi, and xxvii. end groups of d-galactose-1-phosphate in the phosphogalactans of sporobolomyces yeasts made it predictable that these galactans would precipitate the same antipneumococcal sera and also antisera to streptococcal group n. the predictions were verified, and other unpredicted reactions were found. precipitation of much of the ...19684385642
[antimicrobial effect of alpha, alpha-dicyclopentylacetic acid-diethylamino-ethylester-bromoctylate (ug 767)]. 19684386261
lincomycin: a clinical study. 19684386268
synergism between respiratory viruses and bacteria. 19684386279
studies on the role of viruses, bacteria, and m. pneumoniae as causes of lower respiratory tract infections in children. 19684384200
mouse peritoneal cells: their ability to elicit or produce antibody after exposure to antigen. 19684384250
the specific capsular polysaccharide of type vii pneumococcus. 19684386453
[bacteriologic examination of bronchoscopic samples in nontubercular lung diseases in children]. 19684386477
[content of mucoid substances of bronchial secretions in terms of the bronchologic aspect]. 19684386478
the specific substance from pneumococcus type 34 (41). the phosphodiester linkages.1. the phosphate groups in the type-specific substance s.34 from pneumococcus type 34 (u.s. type 41) were shown to join the hydroxyl group at position 1 or 5 of ribitol and the hydroxyl group at position 3 of a d-galactofuranosyl residue in the next repeating unit. 2. a partial structure of the type-specific substance was derived. 3. new syntheses of d-galactose 2-phosphate and d-galactose 3-phosphate are described.19684386682
studies on the pathogenesis of meningitis. vii. glucose transport and spinal fluid production in experimental pneumococcal meningitis. 19684384628
modification of laboratory results by partial treatment of bacterial meningitis. 19684384575
transfer experiments: a plea for tolerance. 19684384316
capsulation of pneumococcus with soluble c-like (cs) polysaccharide. i. biological and genetic properties of cs pneumococcal strains.capsulated mutants of pneumococcus producing a capsule of soluble polysaccharide related immunologically to the c or cell wall polysaccharide of pneumococcus have been isolated from several noncapsulated variants of this organism. the capsular material of these strains reacts with antisera both to homologous strains and to noncapsulated strains of pneumococcus and with human c-reactive protein. c-reactive protein has been shown to give a positive capsular precipitin or quellung reaction with c(s ...19684386878
[the cervico-facial actinomycosis, its early diagnosis. importance of the parasitic polymorphism and of the yellow granules]. 19684386894
a study of the complement fixing properties of equine antisera. 19684386936
use of a pancreatin-trypsin solution for the liquefaction of sputa for routine bacteriological examination. 19684386946
cephaloglycin. clinical and laboratory experience with an orally administered cephalosporin. 19684386947
comparative studies of antibacterial activity in vitro and absorption and excretion of lincomycin and clinimycin. 19684386950
laboratory and clinical evaluation of 7-chloro-7-deoxylincomycin. 19684386951
inhibition of deoxycytidylic and deoxyguanylic acid kinase activity by adenosine triphosphate and deoxyadenosine triphosphate in pneumococci. 19684386977
group a streptococcus resistant to erythromycin and lincomycin. 19684386993
empyema of the thorax in adults: review of 105 cases. 19684386995
[etiological disgnosis of purulent meningitis]. 19684387023
[on the treatment of nonspecific pleural empyema]. 19684387025
comparison of the antibacterial activity of rifampicin and other antibiotics. 19684387027
laboratory and clinical evaluation of rifampicin. 19684387028
[selective media containing nalidixic acid and beta-phenethyl alcohol for the isolation of gram-positive bacteria]. 19684387532
effect of hypothermia on leukocytic phagocytosis in rabbits. 19684387572
an electron microscopic observation on diplococcus-shaped vesicles in papillary muscle of rat heart. 19684387451
immunological properties of anti-pneumococcus rabbit serum as heterophile antibodies. 19684387140
on the lipids of diplococcus pneumoniae type i-r-44. separation of glycolipids from phospholipids by silicic acid column chromatography. 19684387142
fractionated strands of bacterial deoxyribonucleic acid. 3. transformation efficiencies and rates of phenotypic expression.preferential binding of guanine-rich ribopolymers to one of the complementary strands of denatured deoxyribonucleic acid (dna) of diplococcus pneumoniae permitted the fractionation of the complements in cscl density gradients. phenotypic expression of the newly acquired genes for four drug resistances was more rapid in cells transformed by the heavy fractions than in those transformed either by light fractions or by unfractionated dna. the efficiencies of transformation with the two complements ...19684387147
effect of inoculum size on in vitro susceptibility testing with lincomycin.there is disagreement in the literature as to whether lincomycin is primarily a bacteriostatic or a bactericidal agent against gram-positive cocci and also regarding the levels of activity of this agent against susceptible microorganisms. these questions were examined in a study of the effect of inoculum size on the results of tube dilution susceptibility determinations with lincomycin against 49 clinical isolates of staphylococcus aureus and 25 strains of streptococci and pneumococci. lincomyci ...19684387221
cephalexin and cephaloglycin activity in vitro and absorption and urinary excretion of single oral doses in normal young adults.a large number of recently isolated bacterial pathogens were tested for susceptibility to cephalexin and cephaloglycin by the replica inoculating method. strains of group a hemolytic streptococci, viridans (alpha and gamma) streptococci, pneumococci, gonococci, meningococci, and penicillin g-sensitive staphylococcus aureus were all moderately to highly susceptible to both of these cephalosporin analogues, nearly all of the strains being two to eight (median four) times more susceptible to cephal ...19684387222
carbenicillin: activity in vitro and absorption and excretion in normal young men.carbenicillin is a new semisynthetic penicillin which differs from other penicillins in showing moderate antibacterial activity against pseudomonas. its activity in vitro is enhanced at low ph. serum binding is of low order and does not appreciably alter activity. strains of pseudomonas exposed to subinhibitory concentrations of carbenicillin rapidly develop resistance by a mechanism that does not depend upon destruction of the drug. in normal subjects, high levels of anti-pseudomonas activity a ...19684387223
[bacterial transformation]. 19684387271
penicillin-resistant variants of pneumococci.all of the 74 strains of pneumococci isolated from human infections from 1963 to 1964 proved to be uniformly and highly susceptible to penicillin. of these strains, 15 were identified by capsule-swelling reactions and were submitted to serial transfer in the presence of increasing concentrations of penicillin. highly penicillin-resistant mutants were selected from 14 of the 15 strains, whereas one strain was moderately resistant. of these mutants, 11 could still react with specific antiserum, an ...19684384590
[liquid haptens. immunologic properties of the lipid glycosides of aldobionic acid in the polyoside pneumococcal s 3-serum anti s 3 system]. 19684387081
a numerical taxonomic study of human oral streptococci. 19684387086
quantitative studies of the specificity of anti-pneumococcal polysaccharide antibodies, types 3 and 8. 3. binding of a labeled oligosaccharide derived from s8 by anti-s8 antibodies. 19684387095
[recent developments in the field of bacterial transformation]. 19684384987
bacteriology and clinical significance of hemolytic haemophilus in the throat.hemolytic haemophilus are rarely isolated in the clinical laboratory, as they do not grow on sheep or human blood-agar alone. on rabbit blood-agar they grow well and are hemolytic, but they grow less well and are not hemolytic on sheep blood-agar with added x and v factors. a survey was made to determine their incidence in pharyngitis. from 28 of 100 sore throats and from 57 of 100 normal throats, only normal bacterial flora were isolated. beta-streptococci were present in significant numbers in ...19684384589
[antibacterial properties of lincomycin in vitro and its chemotherapeutic activity]. 19684387685
[l-forms of dipl. pneumoniae obtained under the action of penicillin]. 19684387686
effects of polyribonucleotides of known composition on deoxycytidylate and deoxyguanylate kinase activity in pneumococci. 19684385343
levels of resistance in ribosomes from genetically linked, streptomycin-resistant mutants of pneumococcus. 19684385384
deficiency of pneumococcal serum opsonizing activity in sickle-cell disease. 19684385710
[rapid identification of enterococci by means of the oxacillin test]. 19684386067
effect of ph on the resistance of pneumococci to streptomycin. 19684386080
relations between structures of three k polysaccharides of escherichia coli and cross-reactivity in antipneumococcal sera. 19684386081
[study on crp (c-reactive protein)]. 19684388250
mutation in pneumococcus type 3 affecting multiple cistrons concerned with the synthesis of capsular polysaccharide.the genetic behavior in transformation reactions of 20 noncapsulated mutants of pneumococcus type iii suggests that each has a single-site mutation in the locus controlling the synthesis of uridine diphosphate glucose (udpg) dehydrogenase. each strain is capable of yielding transformants of the binary capsular type si-iii when exposed to deoxyribonucleic acid (dna) from type i cells. one additional mutant reacted differently and behaved as if it were a multisite mutant with the mutation affectin ...19684386791
antibodies to pneumococcal polysaccharides: relation between binding and electrophoretic heterogeneity.antibodies to type iii and type viii pneumococcal polysaccharides were examined with respect to ligand binding and electrophoretic heterogeneity. both antibodies showed apparent binding homogeneity, although multiple light chain and heavy chain electrophoretic species were demonstrated.19684386872
pneumococcal c-substance, a ribitol teichoic acid containing choline phosphate.1. pneumococcal c-substance was isolated from the non-capsulated pneumococcus 1-192r, a.t.c.c. 12213, by extraction with trichloroacetic acid solution followed by chromatography on deae-cellulose (hco(3) (-) form). 2. the polymer contains 7.0% of phosphorus and 6.0% of nitrogen and is composed of phosphate, n-acetyl-d-galactosamine, d-glucose, n-acetyldiaminotrideoxyhexose, ribitol and choline in the molecular proportions 2:1:1:1:1:1. 3. after acid hydrolysis, d-galactosamine hydrochloride and g ...19684387389
[antibacterial activity of lincomycin in diseases of the maxillofacial region]. 19684387836
transformation and dna size: two controlling parameters and the efficiency of the single strand intermediate. 19684389184
studies on "intrinsic" allergic respiratory disease, with a hypothesis concerning its pathogenesis. 19684386398
recent developments in lincomycin research. 19684388454
[adansonian's taxonomy and relationship of micro-organisms based on the concepts of similarity value and center species. 4. studies on the relationship of the tribes streptococceae, lactobacilleae and propioni-bacterieae]. 19684386415
[basic and clinical studies on c-reactive proteins]. 19684386416
altered diaphorase activity in optochin-resistant pneumococci.methylene blue (mb) reductase activities of washed cell suspensions and of cell-free extracts prepared from optochin-resistant mutant pneumococci were two times greater than and four to eight times more resistant to optochin inhibition than those of similar preparations from the optochin-sensitive parent strains. with whole cells, optochin hydrochloride was approximately four times more potent than quinine hydrochloride in inhibiting mb reductase activity. however, with cell-free extracts, both ...19684386789
the survival time for different bacteria in various transport media. 19684388644
purification and properties of mutant and wild-type diaphorases from diplococcus pneumoniae.optochin-resistant mutant and wild-type diaphorases were purified approximately 300-fold by a combination of batch adsorption and column chromatography with diethylaminoethyl cellulose, and were characterized with regard to their ph optima, sensitivity to optochin inhibition and heat inactivation, michaelis constants with flavine mononucleotide (fmn) and reduced nicotinamide adenine dinucleotide (nadh), and inhibition constants with optochin hydrochloride. the ph optima of the purified diaphoras ...19684386790
enduracidin, a new antibiotic. 3. in vitro and in vivo antimicrobial activity. 19684386300
an autoradiographic study of genetic transformation. 19684386320
mechanism of the deoxyribonucleic acid helping effect during transformation. 19684387337
[studies on the transmissibility of pathogenic-organisms to liver by migrating larvae of liver fluke and hookworm]in order to confirm whether the migrating larvae of parasites could carry pathogenic organisms into liver and cause hepatitis, a series of experiments has been carried out. a. clonorchis sinensis: recovery rate of larvae in the abdominal cavity of rabbits: one to seven days after the administration adolescariae were recovered from the abdominal cavity in less than l % of the total number of metacercariae given. generally, 1~6 larvae were found from each animal which was given 900~1,000 metacerca ...196812913551
[use of methyldichlorophenylisoxazolyl penicillin (staphcillin a) dry syrup in respiratory infections of children]. 19694389007
[bacteriological studies on penimepicycline]. 19694389008
[antibacterial spectrum of penimepicycline--4'-(beta-hydroxyethyl)-diethylenediaminomethyl-tetracycline phenoxymethylpenicillinate]. 19694389009
type 3 diplococcus pneumonia in laboratory rats.an acute respiratory disease, due to diplococcus pneumoniae type 3, affecting wistar and sprague-dawley rats is described. the infection was experimentally transmitted to sprague-dawley rats. the zoonotic potential of the condition dictated euthanasia of affected animals and instigation of rigid sanitary measures.19694388727
[on the effect of hexetidine in vitro]. 19694388760
synergism between penicillins and lysozyme. data which led to the synthesis of a new antibiotic salt: lysozyme ampicillinate. 3. 19694388763
in vitro antimicrobial activity and human pharmacology of cephalexin, a new orally absorbed cephalosporin c antibiotic.concentrations of cephalexin (an orally absorbed derivative of cephalosporin c) in serum and urine were determined in normal volunteers and patients. the in vitro antibacterial activity was also studied. all strains of group a beta-hemolytic streptococci and diplococcus pneumoniae were inhibited by 3.1 mug/ml. of the staphylococcus aureus strains, 88% were inhibited by 6.3 mug/ml, and 12.5 mug/ml was inhibitory for all s. aureus, 80% of escherichia coli, 72% of klebsiella-aerobacter, and 56% of ...19694388601
tetracycline-resistant pneumococcal infection. incidence, clinical presentation, and laboratory evaluation. 19694388477
engulfment and bactericidal capabilities of peripheral blood leukocytes in chronic leukemias. 19694388486
comparative immunochemical behavior of acid polysaccharides of cryptococcus laurentii, tremella mesenterica and of oxidized cellulose with a type ii antipneumococcal serum. 19694388516
some findings on the endonuclease of pneumococci. 19694389204
unstable binary capsulated transformants in pneumococcus.through transformation reactions, binary capsulated si-iii strains of pneumococci have been isolated that are unstable and lose the si capsular genome at high frequency. the instability is caused by the specific mutation in the siii capsular genome common to all of the unstable strains. in the family of strains studied, the si capsular genome was integrated into the recipient chromosome in at least two loci: one apparently adjacent to the resident capsular genome and a second some distance from ...19694389232
gentamicin in pediatric infections caused by gram-negative organisms. 19694389234
consideration of gentamicin for therapy of neonatal sepsis. 19694389235
laboratory evaluation of erythromycin in a general hospital. 19694389248
a study of the combined role of viruses, mycoplasmas and bacteria in adult pneumonia. 19694387669
microbiological and pharmacological behavior of 7-chlorolincomycin.replacement of the 7-(r) hydroxyl group of lincomycin by a 7-chloro-substituent produced a compound with greater in vitro activity than the parent. laboratory studies of this compound showed it to be highly active against all of the following strains of gram-positive organisms examined, including penicillinase- and nonpenicillinase-producing staphylococci, diplococcus pneumoniae, streptococcus viridans and streptococcus pyogenes. the enterococci, as well as all the gram-negative organisms tested ...19694389137
studies on immunological paralysis. i. a consideration of macrophage involvement in the induction of paralysis and immunity by type ii pneumococcal polysaccharide. 19694389160
studies on immunological paralysis. ii. the detection and significance of antibod-forming cells in the spleen during immunological paralysis with type 3 pneumococcal polysaccharide. 19694389161
[pyrrolo-rifamycin: synthesis and antibacterial properties]. 19694388811
physical behavior of pneumolysin.pneumolysin behaved as an acidic protein having an isoelectric ph of 4.9, a molecular weight of approximately 63,000, and a sedimentation coefficient of approximately 4.3.19694388678
antimicrobial activity of a series of aminoalkyl esters of benzyldithiocarbamic acids. 19694389014
immunofluorescence in the diagnosis of acute bacterial meningitis: a cooperative evaluation of the technique in a clinical laboratory setting. 19694387739
chemotaxis of human eosinophils. 19694387478
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