Publications

molecular detection of tick-borne protozoal and ehrlichial infections in domestic dogs in south africa.	a total of 1,138 blood specimens were collected over a 6-year period (2000-2006) from domestic dogs in south africa. specimens from domestic dogs were obtained from the onderstepoort veterinary academic hospital (ovah) in pretoria, the society for the prevention of cruelty to animals (johannesburg, durban, east london and bloemfontein) and private practices from four provinces (gauteng, mpumalanga, kwazulu-natal and western cape). all specimens were screened for babesia, theileria, hepatozoon an ...	2008	18502588
a quantitative real-time pcr assay for ehrlichia ruminantium using pcs20.	heartwater is a tick borne disease that affects ruminants and wild animals in africa south of the sahara. it is caused by ehrlichia ruminantium and transmitted by the tick amblyomma hebraeum. the protocols currently used to detect heartwater take several days to complete. here, we describe the development of a pcs20 quantitative real-time pcr taqman probe assay to detect e. ruminantium in livestock blood and ticks from the field. the assay is based on the conserved pcs20 gene region of e. rumina ...	2008	18511221
a study of cross-reactivity in serum samples from dogs positive for leishmania sp., babesia canis and ehrlichia canis in enzyme-linked immunosorbent assay and indirect fluorescent antibody test.	to verify the presence of cross-reaction among leishmaniosis, ehrlichiosis and babesiosis in serological diagnostics used in human visceral leishmaniasis control programs, serum samples from leishmaniasis endemic and non-endemic areas were collected and tested by indirect fluorescent antibody (ifat) and enzyme-linked immunosorbent assay (elisa). all serum samples from endemic areas were positive for leishmania sp., by elisa and ifat, 51% positive for babesia canis and 43% for ehrlichia canis by ...	2008	18554433
factors associated with the occurrence of epistaxis in natural canine leishmaniasis (leishmania infantum).	canine leishmaniasis (canl) is a common cause of epistaxis in dogs residing in endemic areas. the pathogenesis of canl-associated epistaxis has not been fully explored because of the limited number of cases reported so far.	2008	18564224
serological reactivity to ehrlichia canis, anaplasma phagocytophilum, neorickettsia risticii, borrelia burgdorferi and rickettsia conorii in dogs from northwestern spain.	the aim of the present work was to investigate the seroprevalence against ehrlichia canis (ec), anaplasma phagocytophilum (ap), neorickettsia risticii (nr), rickettsia conorii (rc), and borrelia burgdorferi (bb) in two different clusters of canine samples from northwestern spain. cluster 1 included 479 dogs presented at veterinary clinics located in ourense and pontevedra. cluster ii included 170 dogs from the public kennel of ourense. all 649 canine serum samples were analyzed by immunofluoresc ...	2008	18597660
canine infection by rickettsiae and ehrlichiae in southern brazil.	this study evaluated the infection caused by rickettsia and ehrlichia agents among dogs in southern brazil. a total of 389 dogs were tested by the indirect immunofluorescence assay (ifa) for rickettsia rickettsii, rickettsia parkeri, rickettsia amblyommii, rickettsia rhipicephali, rickettsia bellii, and ehrlichia canis. overall, 42.4% (165/389) of the dogs were seroreactive to at least one rickettsia species, but only 11 canine sera reacted with another rickettsia species without reacting with r ...	2008	18606772
a survey for infection with dirofilaria immitis, ehrlichia canis, borrelia burgdorferi, and babesia canis in feral and client-owned dogs in the turks and caicos islands, british west indies.	the frequency of infection with dirofilaria immitis and babesia canis and seropositivity to ehrlichia canis and borrelia burgdorferi in feral and client-owned dogs was determined. feral dogs were 14.8 and 11.2 times more likely to be seropositive to d. immitis and e. canis, respectively, than were client-owned dogs. none of the dogs tested positive for b. burgdorferi or b. canis.	2008	18624070
serum cardiac troponin i concentration in dogs with ehrlichiosis.	ehrlichiosis is a multisystemic disease with the potential to cause cardiomyocyte injury in naturally infected dogs.	2008	18638021
molecular characterization of thai ehrlichia canis and anaplasma platys strains detected in dogs.	canine monocytic ehrlichiosis caused by ehrlichia canis is of veterinary importance worldwide. in thailand, there has been little information available on e. canis and its phylogeny. the objective of this study was to characterize and establish molecular structure and phylogeny of thai ehrlichia and anaplasma strains. genus-specific primers for ehrlichia and anaplasma were used to amplify the 16s rrna gene from naturally infected canine blood samples, and these amplicon sequences were compared w ...	2008	17643354
prevalence of ehrlichia canis, anaplasma platys, babesia canis vogeli, hepatozoon canis, bartonella vinsonii berkhoffii, and rickettsia spp. in dogs from grenada.	to identify the tick-borne pathogens in dogs from grenada, we conducted a serologic survey for ehrlichia canis in 2004 (104 dogs) and a comprehensive serologic and molecular survey for a variety of tick-borne pathogens in 2006 (73 dogs). in 2004 and 2006, 44 and 32 dogs (42.3% and 43.8%) were seropositive for e. canis, respectively. in 2006, several tick-borne pathogens were identified by serology and pcr. dna of e. canis, anaplasma platys, babesia canis vogeli, hepatozoon canis, and bartonella ...	2008	18160223
detection of ehrlichia canis by pcr in different tissues obtained during necropsy from dogs surveyed for naturally occurring canine monocytic ehrlichiosis.	a molecular study for the detection of ehrlichia canis was carried out on tissues obtained at necropsy from randomly selected dogs with the intention of investigating naturally-occurring canine ehrlichiosis. the tissues evaluated for the presence of e. canis included lymph nodes, spleen, liver, bone marrow, and blood. eight of the 18 dogs included were found to be positive for e. canis by polymerase chain reaction (pcr) and sequencing of the 16s rrna gene. two dogs were positive for anaplasma pl ...	2008	17368942
detection of ehrlichia canis by polymerase chain reaction in dogs from portugal.	antibodies against ehrlichia canis, the cause of canine monocytic ehrlichiosis, have been reported previously in clinically ill and stray dogs from portugal. in this study, the 16s rrna gene of e. canis was detected by the polymerase chain reaction (pcr) in 12/55 (22%) of dogs with suspected tick-borne disease in the algarve region in portugal.	2009	18682335
atypical clinical presentation of coinfection with ehrlichia, babesia and hepatozoon species in a dog.		2009	19122221
longitudinal quantification of ehrlichia canis in experimental infection with comparison to natural infection.	ehrlichia canis is a major tick-borne bacterial pathogen of dogs. quantitative real-time pcr was evaluated for the detection of e. canis in naturally (ni) and experimentally infected (ei) dogs. dna was extracted from blood, spleen and conjunctival swabs of experimentally infected dogs pre- and post-infection (pi), and during doxycycline therapy, and from blood and conjunctivas of naturally infected dogs. the primers and probe were designed to amplify a 93bp fragment of the single copy e. canis 1 ...	2009	19128893
toward diagnosing leishmania infantum infection in asymptomatic dogs in an area where leishmaniasis is endemic.	the most frequently used diagnostic methods were compared in a longitudinal survey with leishmania infantum-infected asymptomatic dogs from an area of italy where leishmaniasis is endemic. in february and march 2005, 845 asymptomatic dogs were tested by an immunofluorescence antibody test (ifat), a dipstick assay (ds), and an enzyme-linked immunosorbent assay (elisa) for l. infantum and by ifat for ehrlichia canis. dogs seronegative for l. infantum were further parasitologically evaluated by mic ...	2009	19129471
prevalence and geographic distribution of dirofilaria immitis, borrelia burgdorferi, ehrlichia canis, and anaplasma phagocytophilum in dogs in the united states: results of a national clinic-based serologic survey.	we evaluated a comprehensive national database that documents canine infection with, or exposure to, four vector-borne disease agents, dirofilaria immitis, borrelia burgdorferi, ehrlichia canis, and anaplasma phagocytophilum in order to assess geographic trends in rates of positive tests. while the percent positive test results varied by agent in different regions of the united states, with d. immitis antigen and antibodies to e. canis more commonly identified in dogs from the south (3.9% and 1. ...	2009	19150176
indices of urine n-acetyl-beta-d-glucosaminidase and gamma-glutamyl transpeptidase activities in clinically normal adult dogs.	to establish reference ranges for indices of urine n-acetyl-b-d-glucosaminidase (nag) and gamma-glutamyl transpeptidase (ggt) activities in clinically normal adult dogs.	2009	19231965
a suspected case of lyme borreliosis in a hunting dog in korea.	a two-year-old male pointer had been presented with anorexia, cachexia, and weight loss of 10-day duration. upon physical examination, fever, lethargy, superficial lymph node enlargement, and tick infestation were noted. the only abnormality in cbc and serum chemistry analyses was mild hyperglobulinemia. spleen was enlarged by radiography, and the lymph nodes showed neutrophilic lymphadenitis by cytological examination. a polymerase chain reaction test for babesiosis and commercial elisa tests f ...	2009	19255531
development of multiplex polymerase chain reaction for detection of ehrlichia canis, babesia spp and hepatozoon canis in canine blood.	a multiplex polymerase chain reaction (pcr) has been developed for simultaneous detection of canine blood parasites, ehrlichia canis, babesia spp and hepatozoon canis, from blood samples in a single reaction. the multiplex pcr primers were specific to e. canis virb9, babesia spp 16s rrna and h. canis 16s rrna genes. specificity of the amplicons was confirmed by dna sequencing. the assay was evaluated using normal canine and infected blood samples, which were detected by microscopic examination. ...	2009	19323031
effects of therapy on haemostasis in dogs infected with leishmania infantum, ehrlichia canis, or both combined.		2009	19346544
molecular detection of ehrlichia canis in cats in brazil.		2009	19374643
ehrlichia canis and leishmania infantum co-infection: a 3-year longitudinal study in naturally exposed dogs.		2009	19416288
evaluation of a serum-based pcr assay for the diagnosis of canine monocytic ehrlichiosis.	the aim of this study was to estimate the relative diagnostic sensitivity and specificity of a polymerase chain reaction (pcr) assay in the serum of dogs with naturally occurring non-myelosuppressive canine monocytic ehrlichiosis (cme), and to investigate the association between pcr positivity and immunofluorescence antibody (ifa) titres for ehrlichia canis. serum samples obtained from 38 dogs with non-myelosuppressive cme and 12 healthy dogs were analyzed retrospectively. each serum sample was ...	2009	19419823
major species-specific antibody epitopes of the ehrlichia chaffeensis p120 and e. canis p140 orthologs in surface-exposed tandem repeat regions.	ehrlichia chaffeensis and e. canis have a small subset of tandem repeat (tr)-containing protein orthologs, including p120/p140, which elicit strong antibody responses. the tr regions of these protein orthologs are immunoreactive, but the molecular characteristics of the p120/p140 epitopes have not been determined. in this study, the immunodeterminants of the e. chaffeensis p120 and e. canis p140 were identified and molecularly defined. major antibody epitope-containing regions of both p120 and p ...	2009	19420187
a confusing case of canine vector-borne disease: clinical signs and progression in a dog co-infected with ehrlichia canis and bartonella vinsonii ssp. berkhoffii.	abstract : bartonella spp. are important pathogens in human and veterinary medicine, and bartonellosis is considered as an emerging zoonosis that is being reported with increasing frequency. of 22 known species and subspecies of bartonella, seven have been isolated from dogs, causing disease manifestations similar to those seen in human beings. the wide variety of clinical signs and the possible chronic progression of disease manifestations are illustrated in the case of an infected labrador ret ...	2009	19426442
attenuation of ehrlichia canis by multiple passages in two different cultures.		2009	19438628
rapid screening and cultivation of ehrlichia canis from refrigerated carrier blood.		2009	19438630
a molecular and serological study of exposure to tick-borne pathogens in sick dogs from italy.		2009	19456799
ehrlichia canis phylogenetic analysis of the borgo (corsica) strain.		2009	19456800
gammaifn ehrlichia canis-specific cell responses.		2009	19456819
clinical, serological, and molecular evidence of ehrlichiosis and anaplasmosis in dogs in tunisia.	a seroepidemiological survey was conducted in five bioclimatic areas of tunisia to determine the prevalence of antibodies to ehrlichia canis and anaplasma phagocytophilum antigens, surrogate markers of the agents of canine monocytic ehrlichiosis (cme) and canine granulocytic ehrlichiosis, respectively. among 286 collected sera, 54.2% and 25.2% were seropositive for e. canis and a. phagocytophilum, respectively, by the indirect immunofluorescence antibody (ifa) test. clinical and hematological te ...	2009	19018569
an acute severe ehrlichiosis in a dog experimentally infected with a new virulent strain of ehrlichia canis.		2009	19548986
occurrence of dirofilaria immitis and tick-borne infections caused by anaplasma phagocytophilum, borrelia burgdorferi sensu lato and ehrlichia canis in domestic dogs in france: results of a countrywide serologic survey.	the occurrence of dirofilaria immitis antigen and antibodies against tick-borne pathogens in french dogs has been analysed based on 1,050 blood samples. serum samples of 919 dogs (group a) were sent for a variety of diagnostic investigations, further 131 dogs (group b) were tested for a tentative diagnosis of heartworm disease. all samples were tested for d. immitis antigen. samples in group a were also tested for specific antibodies against three tick-borne pathogens (anaplasma phagocytophilum, ...	2009	19575231
comparison of two clinic-based immunoassays with the immunofluorescence antibody test for the field diagnosis of canine monocytic ehrlichiosis.	the aim of this study was to compare a clinic-based enzyme-linked immunosorbent assay (immunocomb-eliza, biogal, israel) and a field-based dot-blot enzyme-linked immunoassay (dbelia) with the indirect immunofluoresence antibody test (ifat) used for the field diagnostics of canine monocytic ehrlichiosis (cme). the total test samples was 60; out of them 52 serum samples came from naturally exposed police german shepherd dogs and 8 from adult mongrels infected with viable ehrlichia canis propagated ...	2009	19621766
use of chimeric dna-rna primers in quantitative pcr for detection of ehrlichia canis and babesia canis.	to overcome the problem of nonspecific by-products in quantitative pcr (qpcr) assays, we constructed dna-rna chimeric primers and evaluated their use in the detection and quantification of the ehrlichia canis 16s rrna, babesia canis hsp70, and canine beta-actin genes. several rna bases were incorporated into specific positions in the dna primers, while no rna stretches were allowed. qpcr reactions were carried out without preamplification steps. this resulted in decreased formation of undesirabl ...	2009	19633128
results from an indirect fluorescent antibody test using three different strains of ehrlichia canis.	an indirect fluorescent antibody (ifa) test is usually performed to detect antibodies in dogs naturally infected by ehrlichia canis. in this work, results obtained using three different e. canis strains as antigen (a commercial antigen, the e. canis oklahoma strain and the e. canis madrid strain) were compared. one hundred and forty-nine serum samples obtained from dogs living in the centre of spain were analysed. when qualitative results were evaluated, identical results were detected in 87.2% ...	2009	18760641
serological survey of ehrlichia canis in stray dogs from yucatan, mexico, using two different diagnostic tests.	canine ehrlichiosis is a disease produced by the rickettsial organism ehrlichia canis. reported prevalence may vary greatly depending on the test and sampling method used. for the serological detection of antibodies against e. canis, the indirect immunofluorescence antibody test (ifa) is considered the gold standard. however, other available serological techniques such as the indirect immunoperoxidase technique (ipt) have not yet been tested and may be efficient in detecting specific antibodies. ...	2009	18945189
molecular evaluation of the incidence of ehrlichia canis, anaplasma platys and babesia spp. in dogs from ribeirão preto, brazil.	canine monocytic ehrlichiosis caused by ehrlichiacanis is endemic in many regions of brazil. since thrombocytopenia is a common finding in infected dogs, many clinicians tend to use it as an indication for antibiotic treatment. polymerase chain reaction (pcr) and nested pcr were used to study the presence of e. canis, anaplasma platys and babesia spp. in thrombocytopenic and non-thrombocytopenic dogs from ribeirão preto, brazil. despite the high prevalence of e. canis infection among thrombocyto ...	2009	17920967
molecular analysis of the rrna genes of babesia spp and ehrlichia canis detected in dogs from ribeirão preto, brazil.	the partial dna sequences of the 18s rrna gene of babesia canis and the 16s rrna gene of ehrlichia canis detected in dogs from ribeirão preto, brazil, were compared to sequences from other strains deposited in genbank. the e. canis strain circulating in ribeirão preto is identical to other strains previously detected in the region, whereas the subspecies babesia canis vogeli is the main babesia strain circulating in dogs from ribeirão preto.	2009	24031351
[urologic examination and treatment of patients with acute injuries of the spinal medulla].	during a period of one year, nine patients with traumatic lesions of the spinal medulla were examined and treated urologically. the patients were followed-up for 24-36 months and follow-up will continue. all of the patients were treated primarily with sterile intermittent catheterization by the nursing staff. exceptions from this were patients in whom indwelling catheters were necessary on account of complicating conditions. during the acute phase, the patients were examined by a urologist and b ...	2009	2773121
platelet calmodulin content in diabetic subjects and its relationship with diabetes-induced hyperaggregability.		2009	3769722
use of phenytoin in healing of war and non-war wounds. a pilot study of 25 cases.	nineteen patients with war-related missile wounds and six with refractory civilian ulcers were treated with topical phenytoin sodium powder daily for up to 4 weeks. the mean healing time was 2 weeks for missile wounds, compared to historical controls requiring 6-8 weeks. healing time was 4 weeks for civilian ulcers that had been unresponsive to any treatment over the previous 5 months. twenty-two patients had complete healing, three required skin grafts. wider use of this safe, inexpensive, read ...	2009	2666326
modelling of reference values for size at birth.	data from the swedish medical birth registration, 1977-1981 were used to apply methods of constructing reference standards for size at birth. using clinical information a 'healthy' sub-population was extracted. the conditional distributions of birthweight (bw) and birthlength (bl) for each week of gestational age, and the conditional distribution of birthweight given birthlength were modelled using truncated normal distributions, after making use of box-cox power transformations. spline function ...	2009	2801107
the roles of stem cell self-renewal and autocrine growth factor production in the biology of myeloid leukemia.		2009	2650863
parents and cataract kids. supporting the family to treat the child.		2009	2913319
three views on unified membership.		2009	2797824
three views on unified membership.		2009	2797824
canine inflammatory myopathy associated with leishmania infantum infection.	inflammatory myopathy associated with several infectious diseases occurs in dogs including those caused by toxoplasma gondii, neospora caninum, ehrlichia canis and hepatozoon canis. however, muscle disease due to leishmania infection has been poorly documented. the aim of this study was to examine the distribution and types of cellular infiltrates and expression of mhc class i and ii in muscle biopsies obtained from 15 male beagle dogs from a breeder group with an established diagnosis of leishm ...	2009	19084398
detection of babesia canis subspecies and other arthropod-borne diseases in dogs from tirana, albania.	summary. the importance of arthropod-borne diseases increased in the recent past in particular due to frequent travel with dogs in or by importing of dogs from regions with endemic occurrence of these diseases. while the epidemiological situation is well known for the western parts of the mediterranean, only limited data is available for eastern europe and the balkans. thirty clinically healthy dogs from suburban areas of tirana, albania, were tested for babesia canis, hepatozoon spp., leishmani ...	2009	19915816
[comparison of nested-pcr with blood smear examination in detection of ehrlichia canis and anaplasma platys in dogs].	the clinical signs of ehrlichia canis and anaplasma platys infection are similar, and the diagnosis of these pathogens made by stained blood smears is poor due sensibility and specificity. on the other hand, the molecular diagnosis is highly sensitive and specific and nested-pcr have been optimized for accurate diagnosis these pathogens in dogs. at the veterinary teaching hospital, whole-blood samples with edta were obtained from 100 dogs and smears were made from blood samples for evaluation fo ...	2009	20040193
ticks and haemoparasites of dogs from praia, cape verde.	in february 2008 an epidemiological field study on arthropod-borne infections in dogs was carried out in praia, the capital city of cape verde. for this purpose 130 dogs were included in the study. of these, 94.6% were infested with ticks. altogether, 1293 ticks of the genus rhipicephalus (in all evaluated cases r. sanguineus) were collected. examination for haemotropic parasites was performed via polymerase chain reaction (pcr). lymph node fine-needle aspirates were screened by pcr for leishman ...	2009	19729247
[ehrlichia canis in dogs attended in a veterinary hospital from botucatu, são paulo state, brazil].	this study investigated the etiology of canine ehrlichiosis and possible clinical and epidemiological data associated with the infection in 70 dogs suspect of ehrlichiosis attended at the veterinary hospital of the são paulo state university in botucatu city during 2001 and 2002. dogs were evaluated by clinical-epidemiological and hematological data and molecular analysis by partial amplification and dna sequencing of the ehrlichial dsb gene. e. canis dna was amplified and sequenced in 28 (40.0% ...	2009	19772777
canine ehrlichiosis in the ivory coast and gabon: alteration of biochemical blood parameters based on ehrlichia canis serology.		2009	19793128
babesia canis and other tick-borne infections in dogs in central poland.	vector-borne infections constitute increasing health problem in dogs worldwide, including sled dogs, dramatically decreasing the fitness of working dogs and even leading to death. in the period 2006-2008 eighty-two blood samples were collected from eight sled dog kennels in central poland. the prevalence of four vector-borne infections (babesia canis, bartonella sp., anaplasma/ehrlichia and borrelia burgdorferi) was estimated in 82 sled dogs using pcr and nested pcr for diagnosis and the same me ...	2009	19837515
[left ventricular pressure-volume diagram determined by forward and backward formatting of radionuclide ventriculography and analog pressure data].	pressure-volume (pv) loop is of great value for the assessment of left ventricular (lv) function, but its clinical application has been limited by methodological complexity. a new system was developed to make accurate loop with simplified procedure, and was applied to clinical and interventional study. the system constitutes of a mobile gamma camera, a poly-amplifier and a data processor (gms-550u, toshiba medical) installed in cardiac catheterization labo for simultaneous raw data handling and ...	2009	2786583
psychiatric expertise in clinical decision making for psychiatric inpatients.	hospital boards and medical staffs are faced with difficult decisions about whether nonphysician mental health professionals should be given admitting privileges to psychiatric hospitals or treatment units. the authors describe the special medical expertise of the psychiatrist and define 11 indicators, such as a patient's need for new psychotropic medication or the presence of symptoms requiring medical or laboratory procedures, that can be used to determine whether psychiatric expertise is need ...	2009	3111970
psychiatric expertise in clinical decision making for psychiatric inpatients.	hospital boards and medical staffs are faced with difficult decisions about whether nonphysician mental health professionals should be given admitting privileges to psychiatric hospitals or treatment units. the authors describe the special medical expertise of the psychiatrist and define 11 indicators, such as a patient's need for new psychotropic medication or the presence of symptoms requiring medical or laboratory procedures, that can be used to determine whether psychiatric expertise is need ...	2009	3111970
desipramine isn't when it's disopyramide.		2009	2739015
allograft tolerance induction in adult mice associated with functional deletion of specific ctl precursors.	rejection of h-2 class i bm 1 mutant skin allografts by b6 recipient mice is mediated by a population of cd8+ anti-bm1 cytotoxic t-lymphocytes that produces and consumes its own t helper factor in response to bm1 skin allografts (dual function ctl). previously we have demonstrated that transfusion of allogeneic lymphocytes across an h-2 class i disparity induces specific long-lasting skin allograft survival. we now show that intravenous injection of allogeneic spleen cells across the bm1 mutant ...	2009	2815256
allograft tolerance induction in adult mice associated with functional deletion of specific ctl precursors.	rejection of h-2 class i bm 1 mutant skin allografts by b6 recipient mice is mediated by a population of cd8+ anti-bm1 cytotoxic t-lymphocytes that produces and consumes its own t helper factor in response to bm1 skin allografts (dual function ctl). previously we have demonstrated that transfusion of allogeneic lymphocytes across an h-2 class i disparity induces specific long-lasting skin allograft survival. we now show that intravenous injection of allogeneic spleen cells across the bm1 mutant ...	2009	2815256
development of neural inducing capacity in dissociated xenopus embryos.	during gastrulation in amphibians, dorsal ectoderm is converted by induction from an epidermal pathway to central nervous system (cns). we show in this report that the ability of the embryo to manufacture this neural inducing signal is not dependent upon intercellular communication between early cleavage and early gastrula stages. this result is consistent with the interpretation that the cell lineage that induces cns formation arises itself by a cell-autonomous mechanism, perhaps specified by m ...	2009	2731653
[prevention of stomatitis induced by anti-cancer drugs].	a randomized control trial study was carried out to evaluate the effect of allopurinol mouth wash on stomatitis induced by chemotherapy in gynecologic patients. chemotherapeutics used consisted of 5-fu+cddp (pf) given to 10 patients and vincristine and actinomycin-d+cyclophosphamide (vac) given to 5. allopurinol mouth wash was prepared for patients to rinse their mouth with the solution 4-5 times daily before and after treatment with anti-cancer drugs. the japan society for cancer therapy's crit ...	2009	2679397
diarrhoeal diseases: perceptions and practices in nepal.	a study undertaken in nepal collected information on believed causes of diarrhoea and traditional treatments. natural causes for diarrhoea were more frequently reported than supernatural causes, the most important being teething (75% of respondents reporting it to be a cause) followed by food considered to be 'cold' in the hindu ayurvedic classification (57.5%), stale food (52.5%), hot food (41%) and dirty water (38%). the terminology reported for dehydration however, indicates strong links with ...	2009	2928835
successful implantation of penile prostheses in organ transplant patients.	we present our experience with implantation of penile prostheses in 6 organ transplant recipients, including 2 patients after renal transplantation and 4 patients after cardiac transplantation. we have seen no problems related to prosthesis surgery in this patient population, and in particular have experienced no infectious complications. all patients received strict perioperative antibiotic and steroid coverage. we conclude that erectile impotence in the male organ transplant patient can be suc ...	2009	2648658
[efficacy of diltiazem in blood pressure increase caused by exertion].	after examining the properties of the 3 most widely used calcium antagonists, the paper assesses the efficacy of diltiazem in reducing blood pressure rises after exercise in a group of 7 patients with chronic atrial fibrillation. the blood pressure response to a standard load (50 w x 3 m2) on the exercise cycle was monitored in a group of patients under chronic digitalis treatment (phase i) after which the same patients' response to varying doses of diltiazem (180-240 mg/day) was assessed (phase ...	2009	2747939
growth inhibitors: molecular diversity and roles in cell proliferation.		2009	2681129
[written information on prescribed drugs provided by pharmacies].		2009	2815030
[written information on prescribed drugs provided by pharmacies].		2009	2815030
[europe 1992: big brother is watching you].		2009	2812101
[europe 1992: big brother is watching you].		2009	2812101
airway obstruction due to goiter in older patients.	it has been shown that goiters can progressively enlarge to compress the surrounding trachea or esophagus and result in incapacitating obstructive symptoms or potentially fatal airway obstruction. the potential of a goiter to become hyperactive also exists. recently, we have seen three older patients with longstanding untreated "benign" goiters who presented difficult management decisions. given the likelihood of progressive growth of a goiter and the increased life expectancy of these patients ...	2009	2687351
[aneurysm of the pancreaticoduodenal arteries and stenosis of the celiac trunk. apropos of a case].	the authors describe the different imaging techniques and their interest. they discuss their etiology. the association with stenosis of the coeliac axis incites to think at a hemodynamic theory.	2009	2681728
elevation of factor vii activity and mass in young adults at risk of ischemic heart disease.	the northwick park heart study found that elevation of factor vii in middle-aged subjects was an independent risk factor for subsequent ischemic heart disease. the present study was designed to determine whether factor vii elevation is present at a younger age and whether zymogen or activated factor vii is responsible for this elevation. a group of 20 asymptomatic first degree relatives (mean age 34.9 years) of patients with premature ischemic heart disease were compared with 15 age-matched norm ...	2009	2794283
sce induction by ccnu and pregnancy.		2009	2704378
therapeutic drug monitoring.		2010	2863512
analysis of the early rise in aortic transvalvular gradient after aortic valvuloplasty.	the relationship between dynamic changes in aortic valve gradient and left ventricular ejection performance in the early period after successful percutaneous aortic valvuloplasty has not been described in detail. accordingly 20 adult patients with severe symptomatic calcific aortic stenosis underwent first-pass radionuclide angiography and doppler echocardiography before, immediately after, and 2 to 4 days after the valvuloplasty procedure. a significant (p less than 0.001) reduction in peak-to- ...	2010	2916414
metaphyseal dysostosis schmidt type.		2010	3251840
[possibility of the early diagnosis of the suture incompetence of a large intestine anastomosis].	radionuclide examinations consisting in intraoperative injection of a nonabsorbed radiopharmaceutical preparation into the lumen of adducting portion of the gut were proposed for the detection of incompetence of anastomosis sutures in the early postoperative period. the investigation was performed in 45 patients. complications on the anastomosis were detected in 7 patients: in 5 patients--anastomositis, in 2 patients--incompetence of the anastomosis sutures, the radiopharmaceutical preparation b ...	2010	2836984
plasma beta-endorphin immunoreactivity (pl-beta-ed-ir) in patients with ulcer disease and its management by acute and chronic administration of gastrozepin.	the initial level of pl-beta-ed-ir was significantly lowered in a group of 14 patients with gastroduodenal ulcer disease as compared with healthy volunteers (p less than 0.05). immediately after i.m. administration of 20 mg gastrozepin (g) the pl-beta-ed-ir level increased but not significantly. given orally over two weeks, g (50 mg/day) led to a more than doubling of the initial level (p less than 0.05). controls showed no significant changes. a further meaningful change represented the time re ...	2010	2937705
truth, trust, and paternalism.	the emphasis on the necessity for fully informed consent in two new books, doctors' dilemmas by m. phillips and j. dawson and whose body is it? by c. faulder, is found to be "lacking in balance" by brewin. the doctor's discretion in dealing with each patient is considered to be the key to determining priorities between paternalism and communication. rigid rules, brewin argues, may not be in the patient's best interest and thus should not be forced on doctors and nurses by "philosophers or expert ...	2010	2863503
effect of exercise training in patients with essential hypertension.	the aim of the present study was to examine the effect of regular exercise training in moderate essential hypertension. twenty subjects (one woman and 19 men) trained for 45 minutes three times a week for 12 weeks, to 60% of their maximal heart rate. blood pressure was measured at rest and during a maximal exercise test on bicycle ergometer. all subjects achieved training effect measured as a significant reduction in heart rate at comparable submaximal work level and a significant increase in du ...	2010	2856772
transport of light in tissue in photodynamic therapy.		2010	2964653
benign extraaxial tumors: contrast enhancement with gd-dtpa.	meningiomas, acoustic neuromas, and other benign extraaxial tumors have little contrast with adjacent brain tissue on conventional magnetic resonance (mr) images. the contrast enhancement produced by intravenous administration of 0.1 mmol/kg of gadolinium-dtpa in these tumors was measured on t1 mr images. acoustic neuromas showed the greatest enhancement (average, 310%), meningiomas the next greatest (average, 180%), and neurofibromas, glomus tumors, and pituitary microadenomas the least enhance ...	2010	3031727
benign extraaxial tumors: contrast enhancement with gd-dtpa.	meningiomas, acoustic neuromas, and other benign extraaxial tumors have little contrast with adjacent brain tissue on conventional magnetic resonance (mr) images. the contrast enhancement produced by intravenous administration of 0.1 mmol/kg of gadolinium-dtpa in these tumors was measured on t1 mr images. acoustic neuromas showed the greatest enhancement (average, 310%), meningiomas the next greatest (average, 180%), and neurofibromas, glomus tumors, and pituitary microadenomas the least enhance ...	2010	3031727
the smoking gun.		2010	2857863
inflammatory pseudotumor of the liver. report of the fine needle aspiration cytologic findings in a case initially misdiagnosed as malignant.	the fine needle aspiration (fna) cytologic features are described in a case of inflammatory pseudotumor of the liver (xanthogranuloma), a disease generally regarded as of unknown etiology. the initial fna findings were those of an acute exudative process, with atypical biliary duct epithelium and hepatocytes. these were interpreted as verifying the radiologic impression of a malignancy. histologic study of subsequently resected nodules revealed the true nature of the case. as the lesion evolved, ...	2010	2929226
origin of leukemic relapse after bone marrow transplantation detected by restriction fragment length polymorphism.	bone marrow transplantation has become an accepted modality in the treatment of acute leukemia. with this therapy, it is possible to obtain long-term disease-free survival. however, leukemia recurs occasionally. in most cases, leukemic relapse is of recipient origin. there have been several reports, though, of leukemia developing in donor cells. these cases have been limited to instances in which there is an easily identifiable chromosome difference or abnormality, usually a sex chromosome. in t ...	2010	2981254
sonographic diagnosis of a chylous mesenteric cyst.		2010	3091647
rhesus haemolytic disease treated with high-dose intravenous immunoglobulin.		2010	2860352
thalidomide, orogenital ulcers, and risk of teratogenicity.		2010	2857866
a case of wound botulism.		2010	2882064
t-butyl-4-hydroxyanisole as an inhibitor of tumor cell respiration.	the effect of t-butyl-4-hydroxyanisole (bha), a widely used food antioxidant additive, on the culture growth, oxygen consumption, and redox state of some electron carriers of intact ta3 and 786a ascites tumor cells has been studied. bha inhibited culture growth and respiration of these two tumor cell lines, by inhibiting the electron flow through the respiratory chain. experiments to determine its site of action showed that bha did not inhibit noticeably the electron flow through cytochrome oxid ...	2010	2818635
absence of myelofibrosis in dogs with myelosuppression induced by ehrlichia canis infection.	bone marrow (bm) pathology was assessed in 10 dogs with ehrlichia canis-induced aplastic pancytopenia. bm core biopsy sections were stained with haematoxylin and eosin and with haematoxylin/van gieson and gordon and sweets' reticulin stain for the detection of collagen and reticulin fibres, respectively. iron stores were assessed by perls' prussian blue staining. there was no significant deposition of collagen or reticulin in any sample, but in seven dogs the bm was depleted of haemosiderin. the ...	2010	19906384
canine babesiosis in northern portugal and molecular characterization of vector-borne co-infections.	abstract:	2010	20377861
comparison of selected canine vector-borne diseases between urban animal shelter and rural hunting dogs in korea.	abstract: a serological survey for dirofilaria immitis, anaplasma phagocytophilum, ehrlichia canis, and borrelia burgdorferi infections in rural hunting and urban shelter dogs mainly from southwestern regions of the republic of korea (south korea) was conducted. from a total of 229 wild boar or pheasant hunting dogs, the number of serologically positive dogs for any of the four pathogens was 93 (40.6%). the highest prevalence observed was d. immitis (22.3%), followed by a. phagocytophilum (18.8% ...	2010	20377869
experimental infection and co-infection of dogs with anaplasma platys and ehrlichia canis: hematologic, serologic and molecular findings.	abstract:	2010	20377870
imported and travelling dogs as carriers of canine vector-borne pathogens in germany.	abstract:	2010	20377872
severe hepatitis associated with acute ehrlichia canis infection in a dog.		2010	20384948
prevalence of dirofilaria immitis, ehrlichia canis, and borrelia burgdorferi in pet dogs, racing greyhounds, and shelter dogs in florida.	arthropod vectors of canine infectious diseases are present throughout florida. since crowded housing has the potential to bring vectors and infected dogs into close proximity, it is possible that prevalence of infection is higher in intensely housed dogs. in this study, the seroprevalence of dirofilaria immitis, ehrlichia canis, and borrelia burgdorferi in dogs residing in two types of intensive housing, greyhound kennels and animal shelters, was compared to dogs residing in low-intensity housi ...	2010	20399018
serological study of selected vector-borne diseases in shelter dogs in central spain using point-of-care assays.	we evaluated the prevalence of selected vector-borne diseases in 131 dogs in an animal shelter in central spain using point-of-care assays (snap 4dx and snap leishmania; idexx laboratories, westbrook, me). the snap 4dx detects dirofilaria immitis (di) antigen and antibodies against ehrlichia canis (ec), borrelia burgdorferi (bb), and anaplasma phagocytophylum (aph); the snap leishmania kit detects antibodies against leishmania infantum (li). dogs were classified as healthy or sick based on physi ...	2010	20420531