Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| jak2 v617f mutation is associated with 5q- syndrome in chinese. | jak2 v617f mutation is mostly seen in bcr-abli negative myeloproliferative neoplasms. among other myeloid neoplasms, it occurs with remarkably high frequency in refractory anemia with ring sideroblasts associated with marked thrombocytosis, a group of myeloid neoplasms with both dysplastic and proliferative features. it has also been reported in occasional cases of myelodysplastic syndrome with isolated del(5q), often with a diagnosis of refractory cytopenia with multilineage dysplasia. we perfo ... | 2009 | 19562618 |
| jak2 v617f mutation in myeloid neoplasms with 3q21 and 3q26 abnormalities in chinese patients. | 2009 | 19562620 | |
| polymorphisms of the estrogen receptor alpha (esr1) gene and the risk of alzheimer's disease in a southern chinese community. | alzheimer's disease (ad) is a neurodegenerative disease with a higher prevalence in women. expression of estrogen receptor 1 (esr1) gene has been identified throughout the brain. owing to the putative neuroprotective effects of estrogen, estrogen receptor gene is a potential candidate modulating the development of ad. preliminary associations between two polymorphisms of esr1 (pvuii and xbai) gene and ad have been reported. | 2009 | 19586561 |
| widespread public misconception in the early phase of the h1n1 influenza epidemic. | to investigate the community responses and preparedness for a possible epidemic of h1n1 influenza in hong kong shortly after an imported case was confirmed. | 2009 | 19592114 |
| cost-effectiveness analysis of influenza and pneumococcal vaccination for hong kong elderly in long-term care facilities. | to compare cost and quality-adjusted life-years (qalys) gained by influenza vaccination with or without pneumococcal vaccination in the elderly living in long-term care facilities (ltcfs). | 2009 | 19608558 |
| epidemiologic risk profile of infection with different groups of human papillomaviruses. | this study identified the age-specific prevalence and epidemiologic risk profile for infection with different groups and species of human papillomaviruses (hpv). structured interview and hpv testing were conducted for 2,604 chinese women self-referred for cervical screening. independent risk factors for infection were identified by multiple logistic regressions. overall, a major peak of hpv infection was observed at women aged 26-30 years, and a minor peak at 46-55 years. this pattern was observ ... | 2009 | 19623668 |
| multidrug-resistant genotype (abcb1) and seizure recurrence in newly treated epilepsy: data from international pharmacogenetic cohorts. | the association between a specific polymorphism (3435c>t) in the abcb1 gene, coding for the membrane drug transporter p-glycoprotein (pgp), and pharmacoresistance to seizure control is controversial. studies have been limited by multiple drug use, chronic cohorts with varying definitions, and retrospective clinical data. herein we examine the relationship of this polymorphism with seizure recurrence in three independent international cohorts of patients newly treated for epilepsy. | 2009 | 19453704 |
| a review on human influenza a h5n1 infections in hong kong. | avian influenza a h5n1 remains the most threatening virus that may cause another devastating pandemic in the foreseeable future. in 1997, hong kong was the first place to detect human infections due to this virus originated from birds. the experience and lessons learnt provide important information for controlling further outbreaks caused by avian influenza viruses. | 2009 | 19471863 |
| confirmation of the first hong kong case of human infection by novel swine origin influenza a (h1n1) virus diagnosed using ultrarapid, real-time reverse transcriptase pcr. | 2009 | 19474268 | |
| implantation of a breathing pacemaker in a tetraplegic patient in hong kong. | a 38-year-old man had been tetraplegic and ventilator-dependent after sustaining a traumatic cervical spine fracture at the c1/c2 level in 1991, at the age of 22 years. he had been bedbound and mechanically ventilated since then. a multidisciplinary management team approached him in 2003 and helped him to become ambulatory and independent in his daily activities of living. we successfully implanted the diaphragm pacing stimulation system in this patient in 2004. diaphragm pacing by phrenic nerve ... | 2009 | 19494383 |
| distribution of human papillomavirus types in cervical cancers in hong kong: current situation and changes over the last decades. | human papillomavirus (hpv) type distribution among cervical cancers and its possible changes over time are key issues that determine the cost-effectiveness of hpv vaccines. cervical cancers diagnosed during 3 periods (1997-2007, n = 280; 1984-1986, n = 74; 1972-1973, n = 81) in hong kong were examined for hpv type distribution using sensitive broad-catching methods. the results showed a variation in hpv distribution between histological groups. among cervical squamous cell carcinoma (scc) cases ... | 2009 | 19507252 |
| occult respiratory viral infections in coronial autopsies: a pilot project. | 2009 | 19509431 | |
| methicillin-resistant commensal staphylococci in healthy dogs as a potential zoonotic reservoir for community-acquired antibiotic resistance. | beta-lactam-resistant staphylococci evolved due to widespread nosocomial antibiotic use during the twentieth century, but the last decade has seen the emergence of genotypically distinct resistant bacteria outside hospitals, such as community-acquired methicillin-resistant staphylococcus aureus (ca-mrsa). this changing epidemiology suggests that mechanisms other than direct antibiotic selection could be involved in the spread of bacterial resistance. here we report a 17% prevalence of methicilli ... | 2009 | 19073283 |
| identification of viral and atypical bacterial pathogens in children hospitalized with acute respiratory infections in hong kong by multiplex pcr assays. | acute respiratory tract infection is a leading cause of hospital admission of children. this study used a broad capture, rapid and sensitive method (multiplex pcr assay) to detect 20 different respiratory pathogens including influenza a subtypes h1, h3, and h5; influenza b; parainfluenza types 1, 2, 3, and 4; respiratory syncytial virus (rsv) groups a and b; adenoviruses; human rhinoviruses; enteroviruses; human metapneumoviruses; human coronaviruses oc43, 229e, and sars-cov; chlamydophila pneum ... | 2009 | 19031443 |
| cultural shift towards sustainability in the construction industry of hong kong. | sustainable development is forward-looking; it is a continuous mission for future developments of human society. a genuinely sustainable society is one that initiates developments in sustainable ways. the development of a genuinely sustainable society is supported by its citizens who think and act according to a recognized code of conduct - the sustainable culture. similar to other forms of culture, sustainable culture of a society is not static, but changes over time. the changes found in a sus ... | 2009 | 19643527 |
| facemasks and hand hygiene to prevent influenza transmission in households: a cluster randomized trial. | few data are available about the effectiveness of nonpharmaceutical interventions for preventing influenza virus transmission. | 2009 | 19652172 |
| contributors to surgical in-patient satisfaction--development and reliability of a targeted instrument. | patient satisfaction is an important indicator of healthcare system performance. high patient satisfaction is associated with greater trust in caregivers, improved compliance with treatment recommendations and a better quality of life (qol). there are few validated instruments to measure surgical patients satisfaction. the aim of this study was to develop a culturally-specific patient satisfaction instrument, for use as an outcome measure in evaluating surgical services. | 2009 | 19656753 |
| factors affecting quickvue influenza a + b rapid test performance in the community setting. | rapid diagnosis of influenza can facilitate timely clinical management. we evaluated the performance of the quickvue influenza a + b test (quidel, san diego, ca) in a community setting and investigated the factors affecting test sensitivity. we recruited 1008 subjects from 30 outpatient clinics in hong kong between february and september 2007. each subject provided 2 pooled pairs of nose and throat swabs; 1 pair was tested by the quickvue rapid test on site, and the other pair was sent to a labo ... | 2009 | 19679233 |
| seasonal influenza activity in hong kong and its association with meteorological variations. | influenza seasons appear consistently in the temperate regions, but are more variable in tropical/subtropical regions. the determinant for such variation remains poorly understood. this study documented the activity of influenza over a 10-year period in hong kong; examining its association with changes in temperature and relative humidity. the two types of influenza exhibited different correlations with meteorological variations. influenza a showed two seasonal peaks occurring respectively in wi ... | 2009 | 19697414 |
| seasonal effects of influenza on mortality in a subtropical city. | influenza has been associated with a heavy burden of mortality. in tropical or subtropical regions where influenza viruses circulate in the community most of the year, it is possible that there are seasonal variations in the effects of influenza on mortality, because of periodic changes in environment and host factors as well as the frequent emergence of new antigenically drifted virus strains. in this paper we explored this seasonal effect of influenza. | 2009 | 19698116 |
| willingness of hong kong healthcare workers to accept pre-pandemic influenza vaccination at different who alert levels: two questionnaire surveys. | to assess the acceptability of pre-pandemic influenza vaccination among healthcare workers in public hospitals in hong kong and the effect of escalation in the world health organization's alert level for an influenza pandemic. | 2009 | 19706937 |
| clinical and molecular epidemiology of human rhinovirus c in children and adults in hong kong reveals a possible distinct human rhinovirus c subgroup. | a novel human rhinovirus (hrv) species, hrv-c, was recently discovered, but its clinical features and epidemiology, compared with hrv-a and hrv-b, remains poorly understood, especially in adults. | 2009 | 19708791 |
| virologically confirmed population-based burden of hospitalization caused by influenza a and b among children in hong kong. | we sought to determine the virologically confirmed hospitalization rates associated with influenza virus infection among hong kong children. | 2009 | 19722912 |
| the burden of influenza in children: time for prevention. | 2009 | 19722913 | |
| epidemiology and clinical presentations of human coronavirus nl63 infections in hong kong children. | human coronavirus nl63 (hcov-nl63) has been found in children presenting with respiratory tract infections (rtis). however, the epidemiology and clinical course of this newly identified virus have not been fully elucidated. this study investigated the epidemiology, seasonality, and clinical features of hcov-nl63 in hong kong children. this study consisted of two cohorts of children hospitalized in a university-affiliated teaching hospital. in the 12-month retrospective part of the study, reverse ... | 2009 | 19759228 |
| the first novel influenza a (h1n1) fatality despite antiviral treatment and extracorporeal membrane oxygenation in hong kong. | we report the first fatality caused by novel influenza a (h1n1) infection despite having the diagnosis confirmed and being given antiviral treatment after hospitalisation. this patient was also the first with influenza a (h1n1) to be supported with extracorporeal membrane oxygenation in hong kong. although extracorporeal membrane oxygenation is an effective means of supporting patients with refractory hypoxaemia on high mechanical ventilatory support, it is labour-intensive and technically deman ... | 2009 | 19801697 |
| structures of receptor complexes formed by hemagglutinins from the asian influenza pandemic of 1957. | the viruses that caused the three influenza pandemics of the twentieth century in 1918, 1957, and 1968 had distinct hemagglutinin receptor binding glycoproteins that had evolved the capacity to recognize human cell receptors. we have determined the structure of the h2 hemagglutinin from the second pandemic, the "asian influenza" of 1957. we compare it with the 1918 "spanish influenza" hemagglutinin, h1, and the 1968 "hong kong influenza" hemagglutinin, h3, and show that despite its close overall ... | 2009 | 19805083 |
| summaries for patients. the effects of hand washing and facemasks on prevention of influenza infection. | 2009 | 19805764 | |
| pressure ulcer development in older residents in nursing homes: influencing factors. | this paper is a report of a study assessing pressure ulcer incidence and factors affecting pressure ulcer development among older nursing home residents. | 2009 | 19824910 |
| influenza-related hospitalisations in children. | to describe the disease burden, clinical pattern and outcome of influenza-related hospitalisations in children. | 2009 | 19845841 |
| acceptability of a/h1n1 vaccination during pandemic phase of influenza a/h1n1 in hong kong: population based cross sectional survey. | objective: to investigate the intention of the hong kong general population to take up vaccination against influenza a/h1n1. setting cross sectional population based anonymous survey. participants random sample of 301 adults interviewed by telephone (response rate 80%). main outcome measure: intention to take up vaccination against influenza a/h1n1 under five hypothetical scenarios: vaccination is free; vaccination per dosage costs less than $hk100 ( pound8; euro9; $13), $hk101-200, or more than ... | 2009 | 19861377 |
| the influence of sars on perceptions of risk and reality. | 2009 | 19884137 | |
| mortality burden of the 1918-1920 influenza pandemic in hong kong. | 2009 | 19903207 | |
| postponement of death around chinese holidays: a hong kong perspective. | historical anecdotes suggest human beings can postpone death around important occasions. some formal studies have claimed that elderly jewish men and chinese women in america postponed death around the passover and harvest moon (or mid-autumn) festival (hmf), respectively. | 2009 | 19907890 |
| detection of an oseltamivir-resistant pandemic influenza a/h1n1 virus in hong kong. | 2009 | 19736041 | |
| the emergence of the novel h1n1 virus: implications for global mental health. | 2009 | 19747424 | |
| acceptance of human papillomavirus vaccination among first year female university students in hong kong. | the present study assessed sexual behaviour, knowledge and attitudes among first year university students in order to identify factors that may affect their acceptance of human papillomavirus (hpv) vaccination. a cross-sectional survey was conducted at the chinese university of hong kong in august 2006. the survey was a self-administered questionnaire comprising questions regarding general health, sexual behaviour, knowledge about hpv and cervical cancer, and attitudes towards vaccination. chi2, ... | 2009 | 19917193 |
| [influenza and other viral diseases, historical reminders of large pandemics]. | 2009 | 20067042 | |
| computer products usage and prevalence of computer related musculoskeletal discomfort among adolescents. | the objective of this study was to investigate the pattern of computer related activities among hong kong adolescents and the prevalence of musculoskeletal discomfort by anatomic sites. this study used a questionnaire-based cross-sectional design. students from year 1 to 7 of six local high schools were invited to complete a student musculoskeletal health questionnaire and computer usage questionnaire. complete data for 3,191 questionnaires was obtained, giving an overall response rate of 95.5%. ... | 2009 | 20075522 |
| influenza-associated hospitalisation. | the disease burden associated with influenza includes not only acute respiratory diseases but also cerebrovascular disease, ischaemic heart disease and diabetes mellitus. | 2009 | 20393224 |
| reducing the impact of the next influenza pandemic using household-based public health interventions. | household-based public health interventions can effectively mitigate the impact of influenza pandemic, and the resources and compliance requirement are realistic and feasible. | 2009 | 20393225 |
| knowledge of risk and self-protection practices and the degree of influenza hazard from live poultry sales. | 1. perceptions of risk from buying live chickens were moderate, but sickness anxieties did not predict buying or touching habits. 2. buying was strongly predicted by the erroneous belief that cooking is the best means of protection from avian influenza. health education groups seeking to increase preventive practices to control possible avian influenza outbreaks need to learn from this. | 2009 | 20393226 |
| [review on the etiological property of 1968 hong kong flu virus (h3n2)]. | 2009 | 20361594 | |
| another nightmare after sars: knowledge perceptions of and overcoming strategies for h1n1 influenza among chronic renal disease patients in hong kong. | in this article i demonstrate the knowledge perceptions of and the preventive health behaviors toward the influenza a h1n1 pandemic, or "human swine flu," among the chronic renal disease patients in hong kong. based on ethnographic data from participant observation in a chronic renal disease patient self-help alliance and semistructured interviews with its 30 members, i demonstrate that the participants' knowledge perceptions of and the adoption of the preventive health behaviors against h1n1 we ... | 2010 | 20363953 |
| quasispecies of the d225g substitution in the hemagglutinin of pandemic influenza a(h1n1) 2009 virus from patients with severe disease in hong kong, china. | the d225g (aspartic acid to glycine) substitution in the hemagglutinin of h1n1 influenza virus may alter its receptor-binding specificity. direct analysis of polymorphisms in 126 amino acids spanning the receptor-binding site in the hemagglutinin of pandemic h1n1 2009 virus from 117 clinical specimens in hong kong found the d225g substitution for 7 (12.5%) of 57 patients with severe disease and for 0 (0%) of 60 patients with mild disease. d225g quasispecies were identified mainly in endotracheal ... | 2010 | 20367331 |
| a defunctioning polymorphism in fcgr2b is associated with protection against malaria but susceptibility to systemic lupus erythematosus. | systemic lupus erythematosus (sle) is a multisystem autoimmune disease more prevalent in people of african and asian origin than caucasian origin. fcgammariib is an inhibitory fc receptor with a critical role in immune regulation. mouse data suggest that fcgammariib deficiency increases susceptibility to autoimmune disease but protects against infection. we show that a snp in human fcgr2b that abrogates receptor function is strongly associated with susceptibility to sle in both caucasians and so ... | 2010 | 20385827 |
| quality of life constructs of chinese people living with hiv/aids. | a range of quality of life (qol) measurements specific for people living with human immunodeficiency virus (hiv)/acquired immune deficiency syndrome (aids) are available. they were, however, developed before or at about the time of introducing highly active antiretroviral therapy (haart) and there has been very little measurement developed from a chinese perspective. a study was therefore undertaken and we report our findings of the first phase, in which chinese people living with hiv/aids in ho ... | 2010 | 20391238 |
| exploring determinants of acceptance of the pandemic influenza a (h1n1) 2009 vaccination in nurses. | this study investigated the anticipated vaccination rate against pandemic human influenza a (h1n1) 2009 in the health care setting. self-administered questionnaires were used to assess nurses' acceptance of vaccination against seasonal flu and h1n1. they were sent to nurses by post through various nurses' unions before initiation of the vaccination program. only 13.3% of the respondents planned to receive the h1n1 vaccine, compared with 37.5% for the seasonal influenza vaccine. vaccination again ... | 2010 | 20566229 |
| controlling alcohol-related global health problems. | alcohol's adverse public health impact includes disease, injury, violence, disability, social problems, psychiatric illness, drunk driving, drug use, unsafe sex, and premature death. furthermore, alcohol is a confirmed human carcinogen. the international agency for research on cancer concluded that alcohol causes cancer of the oral cavity, pharynx, larynx, esophagus, liver, colon-rectum, and breast. world cancer research fund/american institute for cancer research concluded that the evidence jus ... | 2010 | 20566555 |
| a single nucleotide polymorphism in apoa5 determines triglyceride levels in hong kong and guangzhou chinese. | single nucleotide polymorphisms (snps) in the apolipoprotein a5 (apoa5) gene have been associated with hypertriglyceridaemia. we investigated which snps in the apoa5 gene were associated with triglyceride levels in two independent chinese populations. in all, 1375 subjects in the hong kong cardiovascular risk factor prevalence study were genotyped for five tagging snps chosen from hapmap. replication was sought in 1996 subjects from the guangzhou biobank cohort study. among the five snps, rs6627 ... | 2010 | 20571505 |
| monitoring of perceptions, anticipated behavioral, and psychological responses related to h5n1 influenza. | the aim of this study was to monitor changes in behavioral and emotional responses to human h5n1 in the community over a 28-month period (from november 2005 to february 2008). | 2010 | 20582562 |
| the enterovirus 71 epidemic in 2008--public health implications for hong kong. | we compared the epidemiological, clinical and laboratory characteristics of enterovirus 71 (ev71) cases recorded in the epidemic year of 2008 with those of the past decade. | 2010 | 20599410 |
| virologically confirmed population-based burden of hospitalization caused by respiratory syncytial virus, adenovirus, and parainfluenza viruses in children in hong kong. | to determine virologically confirmed hospitalization rates associated with respiratory syncytial virus (rsv), adenovirus, and parainfluenza viruses in hong kong children. | 2010 | 20622713 |
| the effect of school-based cervical cancer education on perceptions towards human papillomavirus vaccination among hong kong chinese adolescent girls. | objective: to evaluate the effects of school-based cervical cancer education on hong kong chinese adolescent girls. methods: adolescent girls (n=953) in local secondary schools attended a tailored educational program on cervical cancer prevention. self-administered questionnaires were used before and after the program to measure its effects on participants' knowledge, attitude and perceived social norms towards human papillomavirus (hpv) vaccination and their intention to be hpv vaccinated. resu ... | 2010 | 20650592 |
| evidence for geographical and racial variation in serum sex steroid levels in older men. | despite considerable racial and geographical differences in human phenotypes and in the incidence of diseases that may be associated with sex steroid action, there are few data concerning variation in sex steroid levels among populations. we designed an international study to determine the degree to which geography and race influence sex steroid levels in older men. | 2010 | 20668046 |
| community psychological and behavioral responses through the first wave of the 2009 influenza a(h1n1) pandemic in hong kong. | little is known about the community psychological and behavioral responses to influenza pandemics. | 2010 | 20677945 |
| diagnostic challenges of human brucellosis in hong kong: a case series in two regional hospitals. | a retrospective analysis of six patients diagnosed with brucellosis in two regional hospitals was carried out. the epidemiological, clinical, and laboratory features were studied. all patients had exposure history. three patients presented with musculoskeletal symptoms, while three had predominantly genitourinary symptoms. one patient did not have fever at presentation. all patients were diagnosed by positive blood culture of brucella melitensis, and the diagnosis was not suspected for all excep ... | 2010 | 20683074 |
| h1n1 influenza virus reassorting in pigs, poses unknown risk to human health. | 2010 | 20699449 | |
| experiences sharing of implementing template-based electronic medical record system (temrs) in a hong kong medical organization. | this paper aims to investigate the efficacy and feasibility of template-based electronic medical record system (temrs) and factors for its successful implementation. a temrs was designed and implemented in one core clinic of a hong kong professional multi-disciplinary medical services provider with four core clinics located in different parts of hong kong. eight doctors participated in the study. surveys and interviews were conducted to acquire the users' feedback and satisfaction level. the des ... | 2010 | 20703758 |
| host-specific 16s rrna gene markers of bacteroidales for source tracking of fecal pollution in the subtropical coastal seawater of hong kong. | this study investigated the diversity of bacteroidales communities in the feces of eight host species in hong kong (subtropical asia), including human (in the form of sewage), cow, pig, horse, cat, dog, rabbit and rat. the analysis of terminal restriction fragment length polymorphism (trflp) in the 16s rrna genes revealed significant differences in bacteroidales communities among all host species, with the exception of dog and cat. manual examination of trflp profiles resulted in six terminal re ... | 2010 | 20705317 |
| enrichment of polycyclic aromatic hydrocarbons (pahs) in mariculture sediments of hong kong. | surface and core sediments collected from six fish farms in hong kong and from reference sites were investigated for the enrichment and sources of polycyclic aromatic hydrocarbons (pahs). moderately high sigmapah16 levels (123-947 ng g(-1), mean: 450 ng g(-1)) were found in the surface aquaculture sediments. in comparison with the sediments from the reference sites, the average enrichment percentage of total organic carbon (toc) and pahs in surface sediments were 21.4 and 43.8%, respectively, an ... | 2010 | 20708314 |
| genetic susceptibility for chronic lymphocytic leukemia among chinese in hong kong. | the genetic basis of chronic lymphocytic leukemia (cll) has not been fully elucidated to date. although it is the most common haematological malignancy in caucasians, it is uncommon among asians. a recent genome-wide scan of cll in caucasians, which was carried out in the uk, identified six variants showing strong association. we attempted to replicate these findings in 71 patients with cll and 1273 controls in hong kong chinese. three of the six variants were significantly associated with cll. ... | 2010 | 20731705 |
| pandemic influenza a (2009-h1n1) infection in paediatric oncology patients in hong kong. | 2010 | 20738303 | |
| pharmacogenetics of esomeprazole or rabeprazole-based triple therapy in helicobacter pylori eradication in hong kong non-ulcer dyspepsia chinese subjects. | our study aimed to assess the effectiveness of esomeprazole or rabeprazole in combination with amoxicillin and clarithromycin for the eradication of helicobacter pylori in hong kong non-ulcer dyspepsia (nud) patients. | 2010 | 20831535 |
| fear appeals and public service advertising: applications to influenza in hong kong. | 2010 | 20845150 | |
| association of srd5a2 variants and serum androstane-3alpha,17beta-diol glucuronide concentration in chinese elderly men. | results of recent studies have demonstrated that genetic variants of the enzyme steroid 5α reductase type ii (srd5a2) are associated with serum concentrations of major androgen metabolites such as conjugates of androstane-3α,17β-diol-glucuronide (3α-diol-g). however, this association was not consistently found among different ethnic groups. thus, we aimed to determine whether the association with srd5a2 genetic variations exists in a cohort of healthy chinese elderly men, by examining 2 metaboli ... | 2010 | 20855474 |
| sero-immunity and serologic response to pandemic influenza a (h1n1) 2009 virus in hong kong. | to study the serologic response to the new pandemic influenza a (h1n1) 2009 virus in hong kong, the level of immunity was measured before and after the occurrence of the outbreak, and the titer of antibody to the pandemic influenza a (h1n1) 2009 virus in serum samples of laboratory confirmed cases. the presence of pre-outbreak pandemic influenza a (h1n1) 2009 virus antibodies in 37% of individuals older than >65 years suggested previous exposures to heterologous virus strains may have elicited c ... | 2010 | 20872705 |
| comparison of the incidence of influenza in relation to climate factors during 2000-2007 in five countries. | relatively few international comparisons of the incidence of influenza related to climate parameters have been performed, particularly in the eastern hemisphere. in this study, the incidence of influenza and climate data such as temperature, relative humidity, and rainfall, from cities at different latitudes with contrasting climates: singapore, hong kong (china), ulaanbaatar (mongolia), vancouver (canada), and three australian cities (brisbane, melbourne and sydney) were examined to determine w ... | 2010 | 20872724 |
| influenza and parainfluenza associated pediatric icu morbidity. | to investigate if morbidity in young children admitted to a pediatric intensive care unit (picu with a laboratory proven diagnosis of influenza and parainfluenza infection) had increased. | 2010 | 20882437 |
| possible role of aerosol transmission in a hospital outbreak of influenza. | we examined the role of aerosol transmission of influenza in an acute ward setting. | 2010 | 20942655 |
| how is health a security issue? politics, responses and issues. | in the closing decade of the 20th century the myriad challenges posed by infectious disease in a globalized environment began to be re-conceptualized as threats to national and human security. the most widely applied model for identifying and responding to such threats is securitization theory, as proposed by the copenhagen school. although its analytical framework is generally accepted, its utility remains contested; especially in non-european and non-state settings. the papers in this special ... | 2010 | 20961945 |
| the infection attack rate and severity of 2009 pandemic h1n1 influenza in hong kong. | serial cross-sectional data on antibody levels to the 2009 pandemic h1n1 influenza a virus from a population can be used to estimate the infection attack rates and immunity against future infection in the community. | 2010 | 20964521 |
| situational awareness and health protective responses to pandemic influenza a (h1n1) in hong kong: a cross-sectional study. | whether information sources influence health protective behaviours during influenza pandemics or other emerging infectious disease epidemics is uncertain. | 2010 | 20967280 |
| willingness to accept h1n1 pandemic influenza vaccine: a cross-sectional study of hong kong community nurses. | the 2009 pandemic of influenza a (h1n1) infection has alerted many governments to make preparedness plan to control the spread of influenza a (h1n1) infection. vaccination for influenza is one of the most important primary preventative measures to reduce the disease burden. our study aims to assess the willingness of nurses who work for the community nursing service (cns) in hong kong on their acceptance of influenza a (h1n1) influenza vaccination. | 2010 | 21034439 |
| facing the threat of influenza pandemic - roles of and implications to general practitioners. | the 2009 pandemic of h1n1 influenza, compounded with seasonal influenza, posed a global challenge. despite the announcement of post-pandemic period on 10 august 2010 by the who, h1n1 (2009) virus would continue to circulate as a seasonal virus for some years and national health authorities should remain vigilant due to unpredictable behaviour of the virus. majority of the world population is living in countries with inadequate resources to purchase vaccines and stockpile antiviral drugs. basic h ... | 2010 | 21044300 |
| association of the pou class 2 homeobox 1 gene (pou2f1) with susceptibility to type 2 diabetes in chinese populations. | pou class 2 homeobox 1 (pou2f1), also known as octamer-binding transcription factor-1 (oct-1), is a ubiquitous transcription factor that plays a key role in the regulation of genes related to inflammation and cell cycles. pou2f1 is located on chromosome 1q24, a region with linkage for type 2 diabetes in chinese and other populations. we examined the association of pou2f1 genetic variants with type 2 diabetes in hong kong chinese using two independent cohorts. | 2010 | 21059098 |
| protective efficacy of seasonal influenza vaccination against seasonal and pandemic influenza virus infection during 2009 in hong kong. | the relationship between seasonal influenza vaccine and susceptibility to 2009 pandemic a/h1n1 virus infection is not fully understood. | 2010 | 21067351 |
| reconstruction of epidemic curves for pandemic influenza a (h1n1) 2009 at city and sub-city levels. | to better describe the epidemiology of influenza at local level, the time course of pandemic influenza a (h1n1) 2009 in the city of hong kong was reconstructed from notification data after decomposition procedure and time series analysis. gis (geographic information system) methodology was incorporated for assessing spatial variation. between may and september 2009, a total of 24415 cases were successfully geocoded, out of 25473 (95.8%) reports in the original dataset. the reconstructed epidemic ... | 2010 | 21078195 |
| risk factors for cervical abnormalities among hong kong chinese women: a large-scale community-based cervical screening program. | we sought to identify the prevalence of and risk factors associated with cervical abnormalities among chinese women in hong kong. | 2010 | 21091197 |
| downregulation of aspp1 in gestational trophoblastic disease: correlation with hypermethylation, apoptotic activity and clinical outcome. | gestational trophoblastic disease encompasses a spectrum of trophoblastic lesions including true neoplasms such as choriocarcinomas and the potentially malignant hydatidiform moles, which may develop persistent disease requiring chemotherapy. aspp1, a member of apoptosis-stimulating proteins of p53 (aspps), is a proapoptotic protein that can stimulate apoptosis through its interaction with p53. we evaluated the promoter methylation and expression profiles of aspp1 in different trophoblastic tiss ... | 2010 | 21102414 |
| network analysis of global influenza spread. | although vaccines pose the best means of preventing influenza infection, strain selection and optimal implementation remain difficult due to antigenic drift and a lack of understanding global spread. detecting viral movement by sequence analysis is complicated by skewed geographic and seasonal distributions in viral isolates. we propose a probabilistic method that accounts for sampling bias through spatiotemporal clustering and modeling regional and seasonal transmission as a binomial process. a ... | 2010 | 21124942 |
| pandemic influenza 1918 h1n1 and 1968 h3n2 dna vaccines induce cross-reactive immunity in ferrets against infection with viruses drifted for decades. | alternative influenza vaccines and vaccine production forms are needed as the conventional protein vaccines do not induce broad cross-reactivity against drifted strains. furthermore, fast vaccine production is especially important in a pandemic situation, and broader vaccine reactivity would diminish the need for frequent change in the vaccine formulations. | 2010 | 21138536 |
| outbreak of influenza a (h1n1) virus infection in a nursing school in hong kong. | 2010 | 20415577 | |
| snps of fc-gamma receptor genes and chronic periodontitis. | genetic polymorphisms of host defense genes might increase risk for periodontitis. this case-control study investigated whether 102 single-nucleotide polymorphisms (snps) in fc gamma receptor (fcgr) genes are associated with chronic periodontitis. cases were 190 hong kong chinese patients with severe chronic periodontitis, and there were 169 periodontitis-free individuals as controls. genotype cc and allele c of rs445509 (p < 0.0001, or = 0.30) of fcgr3a were significantly more prevalent among c ... | 2010 | 20439936 |
| polycyclic aromatic hydrocarbons (pahs) in different indoor dusts and their potential cytotoxicity based on two human cell lines. | in this study, 55 air-conditioner filter dust samples from six different workplaces including commercial office, secondary school, shopping mall, hospital, electronic factory and manufacturing plant in hong kong were collected for analyses of pah concentration and cytotoxicity. chemical analyses showed that the total pahs ranged from 1.17 to 25.5 microg/g, with the dust samples from manufacturing plant having the highest concentration. mtt (3-[4, 5-dimethylthiazol-2-yl]-2, 5-diphenyltetrasodium ... | 2010 | 20452024 |
| factors in association with acceptability of a/h1n1 vaccination during the influenza a/h1n1 pandemic phase in the hong kong general population. | a random population-based telephone survey (n=301) was conducted among the hong kong general population in july 2009. past history of seasonal influenza vaccination (or=2.59-3.13) was associated with intention to take up a/h1n1 vaccination under three hypothetical scenarios (provided at <hk$100, hk$100-200 and >hk$200). adjusting background variables, other significant factors were identified by stepwise models: perceived side effects (or=0.33), family members' recommendations and friends' accep ... | 2010 | 20457289 |
| development of a dose-response model for sars coronavirus. | in order to develop a dose-response model for sars coronavirus (sars-cov), the pooled data sets for infection of transgenic mice susceptible to sars-cov and infection of mice with murine hepatitis virus strain 1, which may be a clinically relevant model of sars, were fit to beta-poisson and exponential models with the maximum likelihood method. the exponential model (k= 4.1 x l0(2)) could describe the dose-response relationship of the pooled data sets. the beta-poisson model did not provide a st ... | 2010 | 20497390 |
| a novel modeling framework for multilayered soft tissue deformation in virtual orthopedic surgery. | realistic modeling of soft tissue deformation is crucial to virtual orthopedic surgery, especially orthopedic trauma surgery which involves layered heterogeneous soft tissues. in this paper, a novel modeling framework for multilayered soft tissue deformation is proposed in order to facilitate the development of orthopedic surgery simulators. we construct our deformable model according to the layered structure of real human organs, and this results in a multilayered model. the division of layers ... | 2010 | 20503610 |
| avoidance behaviors and negative psychological responses in the general population in the initial stage of the h1n1 pandemic in hong kong. | during the sars pandemic in hong kong, panic and worry were prevalent in the community and the general public avoided staying in public areas. such avoidance behaviors could greatly impact daily routines of the community and the local economy. this study examined the prevalence of the avoidance behaviors (i.e. avoiding going out, visiting crowded places and visiting hospitals) and negative psychological responses of the general population in hong kong at the initial stage of the h1n1 epidemic. | 2010 | 20509887 |
| influence of country of study on student responsiveness to the h1n1 pandemic. | university students, both travelling abroad on holiday or exchange students entering a country, can serve as mobile carriers of infectious diseases during a pandemic, and thus require special attention when considering preventive measures. the objectives of this study were to evaluate student compliance and opinions on preventive measures of a university before and during an h1n1 influenza pandemic, and to explore environmental and behavioural factors that might contribute towards compliance. | 2010 | 20510428 |
| human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine: immunogenicity and safety in healthy chinese women from hong kong. | to assess the immunogenicity and safety of human papillomavirus-16/18 as04-adjuvanted cervical cancer vaccine in chinese women aged 18 to 35 years enrolled from hong kong. | 2010 | 20519752 |
| the epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in hong kong. | to evaluate the epidemiology and clinical manifestations of human immunodeficiency virus-associated tuberculosis in hong kong. | 2010 | 20519755 |
| profiling advanced disease in an asian clinical human immunodeficiency virus cohort: comparison of two definitions for acquired immunodeficiency syndrome. | to compare advanced human immunodeficiency virus disease defined immunologically and clinically by evaluating the characteristics of human immunodeficiency virus patients in hong kong. | 2010 | 20519756 |
| outcomes of adults hospitalised with severe influenza. | the aim of this study was to investigate factors affecting clinical outcomes of adults hospitalised with severe seasonal influenza. | 2010 | 20522848 |
| epidemiology and clinical features of shewanella infection over an eight-year period. | shewanella is a rare human pathogen that can lead to fatal infections. however, clinical information about this bacterium remains scarce. in this study, we retrospectively reviewed all patients with laboratory isolates of shewanella over an 8-y period to assess risk factors, clinical manifestations and outcome. twenty-nine patients were identified. shewanella was most commonly isolated from intra-abdominal specimens (48.2%), followed by skin and soft tissue specimens (27.6%), blood (13.8%) and s ... | 2010 | 20524786 |
| independent predictive roles of eotaxin ala23thr, paraoxonase 2 ser311cys and beta-adrenergic receptor trp64arg polymorphisms on cardiac disease in type 2 diabetes--an 8-year prospective cohort analysis of 1297 patients. | to examine the independent and joint effects of multiple genetic variants on a cardiac end-point in an 8-year prospective study of a chinese diabetic cohort. | 2010 | 20536507 |
| prevalence of influenza vaccination and associated factors among pregnant women in hong kong. | a total of 568 pregnant women in hong kong were interviewed. of them, 85.4% had heard of influenza vaccine, 21.3% had ever been vaccinated, 3.9% self-reported receiving influenza vaccination (iv) in the 2005/2006 flu season, and 33% were inclined toward receiving iv in the coming year. multivariate analysis showed that those who had been recommended by health care professionals to receive iv during pregnancy were more likely than others to have received iv. other variables related to the health ... | 2010 | 20542072 |
| health risk assessment of abandoned agricultural soils based on heavy metal contents in hong kong, the world's most populated city. | the objective of this study was to evaluate the consequence of changing and using agricultural soils to other purposes in hong kong with respect to risk to human health. this study established concentrations of the following priority elements: as, cu, cd, cr, pb and zn in terms of total burden (using mixed acid microwave digestion) and with respect to metal bioaccessibility (using an in vitro simulated gastric solution). 55 locations were sampled representing 12 different land use types, namely, ... | 2010 | 20552725 |
| detection of novel astroviruses in urban brown rats and previously known astroviruses in humans. | several novel astroviruses have been recently discovered in humans and in other animals. here, we report results from our surveillance of astroviruses in human and rodent faecal samples in hong kong. classical human astroviruses (n=9) and a human mlb1 astrovirus were detected in human faecal samples (n=622). novel astroviruses were detected from 1.6 % of the faecal samples of urban brown rat (rattus norvegicus) (n=441), indicating the prevalence of astrovirus infection in rats might be much lowe ... | 2010 | 20554799 |
| comparative epidemiology of pandemic and seasonal influenza a in households. | there are few data on the comparative epidemiology and virology of the pandemic 2009 influenza a (h1n1) virus and cocirculating seasonal influenza a viruses in community settings. | 2010 | 20558368 |