Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| the effects of a supratentorial mass lesion on brain-stem auditory evoked potentials and short latency somatosensory evoked potentials. | nineteen patients with unilateral supratentorial mass lesion and without any evident clinical signs of transtentorial herniation were studied with computed tomography (ct), brain-stem evoked potentials (baeps) and central conduction time (cct) of short latency somatosensory evoked potentials (seps). sixteen had tumours, two had intracranial haematoma and one had chronic subdural haematoma. ct detected the initial signs of transtentorial herniation in every case. preoperative i-v interpeak latenc ... | 2010 | 2871503 |
| opportunities for lay midwifery practice. | 2010 | 2929822 | |
| pharmacokinetics and effect on blood pressure of doxazosin in normal subjects and patients with renal failure. | the antihypertensive efficacy and pharmacokinetics of a single 1 mg oral dose of doxazosin were investigated in five healthy male volunteers, six patients with renal failure not on hemodialysis, and four patients with end-stage renal failure studied between two hemodialyses. the dialyzability of doxazosin was studied in five patients. the maximum fall in blood pressure of both volunteers and patients occurred between 4 and 8 hours. in four of five volunteers the blood pressure had returned to ba ... | 2010 | 2945688 |
| selective effects of enzyme treatment used for dissociating single cells on their gaba-receptor activities. | frog dorsal root ganglion (drg) cells treated with collagenase and trypsin were dissociated mechanically. the characteristics of dose-response curves of gaba-induced cl- currents (icl) were mainly studied using the "concentration-clamp" technique, by which the external solution around isolated single neurons was rapidly changed within a few milliseconds. the saturating maximum currents induced by various concentrations of gaba normalized to the peak icl induced by 10(-5) m gaba on the same neuro ... | 2010 | 2829067 |
| determination of pyrimidine 5'-nucleotidase (p5n) activity in whole blood as an index of lead exposure. | a simple method for determining pyrimidine 5'-nucleotidase (p5n) activity in whole blood has been developed, inhibiting the plasma activity for ump-hydrolysis by concanavalin (con a). con a specifically inhibits the activity of plasma 5'-nucleotidase (5n) but does not affect erythrocyte p5n activity. the anticoagulant edta partially inhibits 5n activity but slightly activates p5n. p5n activity determined by the present method with heparinised blood and con a was comparable with that by the metho ... | 2010 | 2840110 |
| cross-linking site in fibrinogen for alpha 2-plasmin inhibitor. | a plasma proteinase inhibitor, alpha 2-plasmin inhibitor (alpha 2pi), is cross-linked with alpha chain of fibrin(ogen) by activated coagulation factor xiii (plasma transglutaminase). alpha 2pi serves only as a glutamine substrate (amine acceptor) for activated factor xiii in the cross-linking reaction, and the cross-linking occurs between gln-2 of the alpha 2pi molecule and a lysine residue (amine donor) of fibrin(ogen) alpha chain, whose position was investigated. alpha 2pi and fibrinogen were ... | 2010 | 2877981 |
| [exorbitant responsibilities!]. | 2010 | 2814197 | |
| the organization of the cholinergic synapse. | 2010 | 2904504 | |
| peripheral neuropathy associated with mitochondrial myopathy. | twenty patients with mitochondrial myopathy were investigated for the presence of peripheral neuropathy. there were clinical features of a mild sensorimotor neuropathy in five patients (25%) and nerve conduction studies were abnormal in 10 patients (50%). electrophysiological studies of the whole group showed significant impairment of motor and sensory conduction compared with controls. sural nerve biopsy and morphometric studies were performed on four patients with clinical neuropathy. there wa ... | 2010 | 2849395 |
| low-dose aspirin in pregnancy. | in a prospective study, we evaluated the effects of low-dose aspirin on maternal and neonatal plasma 6-keto-prostaglandin (pg) f1 alpha concentration, platelet aggregation, platelet thromboxane production, and neonatal transitional circulation. forty women, at a mean (+/- sd) of 37 +/- 2 weeks' gestation, were randomized to receive (n = 10 each) placebo or 20, 60, or 80 mg of aspirin per day until delivery. maternal serum 6-keto-pgf1 alpha levels were not affected by these doses of aspirin, wher ... | 2010 | 2797631 |
| prognostic and therapeutic observations of manifestations in the genitourinary tract of adenocarcinoma of the colon and rectum. | to evaluate the significance of involvement of the genitourinary tract in adenocarcinoma of the colon and rectum, we received the records of 178 patients with adenocarcinoma of the colon and rectum admitted to the university of massachusetts medical center from 1980 to 1985. sixty-eight patients (38 per cent) had urologic manifestations categorized as ureteral obstruction or injury (34 per cent), invasion to the bladder or prostate, or both (10 per cent), isolated gross hematuria (18 per cent), ... | 2010 | 2814767 |
| the complete nucleotide sequence of tetanus toxin. | 2010 | 3774547 | |
| [pulmonary sarcoidosis with bullous development]. | 2010 | 2966391 | |
| interactions between catecholamines and their receptors in blood. | 2010 | 3032424 | |
| [dubowitz syndrome. presentation of a case]. | 2010 | 3178992 | |
| [application of ptca steerable guide wire for abdominal and peripheral interventional angiography]. | 2010 | 2975374 | |
| [diabetes-myxedema]. | 2010 | 5054127 | |
| ex vivo platelet studies following oral nisoldipine in normotensive insulin-dependent diabetics and non-diabetic controls. | the effect of 24 hours and 7 days treatment with nisoldipine (10 mg, twice daily) on platelet function was studied in 12 normotensive volunteers of whom six were insulin-dependent diabetics without clinical evidence of vascular complications. platelet aggregation was assessed by platelet rich plasma (prp) and whole blood (wb) techniques. in addition, the effect of nisoldipine on platelet hyperaggregability following exercise was assessed. after taking nisoldipine for 24 hours, in vitro platelet ... | 2010 | 2976336 |
| antiprotease capacity in acute pancreatitis. | serial measurements of circulating antiproteases were carried out on 42 consecutive patients admitted with acute pancreatitis. in the 7 days following admission the serum levels of alpha 1 antitrypsin (alpha 1 at), alpha 1 antichymotrypsin (alpha 1 act) and the trypsin inhibitory capacity (tic) increased by more than 300 per cent. the serum concentration of alpha 2 macroglobulin (alpha 2 m) alone showed a decline which was most profound in those patients with severe acute pancreatitis. initial e ... | 2010 | 3768647 |
| selective effects of ect on hypothalamic-pituitary activity. | the hypothesis that ect produces selective effects on hypothalamic-pituitary activity was investigated by determining the effect of ect on pituitary hormone release in nine depressed patients. after ect there were massive and rapid increases in the plasma concentrations of nicotine- and oestrogen-stimulated neurophysin (nsn and esn), prolactin (prl) and adrenocorticotropin (acth), smaller increases in plasma luteinizing hormone (lh) and cortisol, a significant decrease in plasma growth hormone ( ... | 2010 | 3037582 |
| [studies on attenuation of cardiovascular responses during endotracheal intubation following rapid-sequence induction of anesthesia]. | 2010 | 2976320 | |
| [in vitro development of blastema cells in axolotl limb regeneration: effect of insulin and nerve extracts on cellular proliferation]. | for the purpose of investigating the nature of the nervous factor which controls cell proliferation in limb blastema of newts, we have cultured primary mesenchymous cells from limb blastemas of axolotl. the cultures were carried out in petri dishes (primaria, falcon) with a basal medium with contained diluted mem supplemented with hormones (insulin, somatotropin, hydrocortisone and thyroxine). in this medium, the cells disperse from the explant from the 4th day of culture and begin to divide fro ... | 2010 | 2952210 |
| [a new procedure for the biological denitrification of ground water]. | 2010 | 2950354 | |
| use of laboratories owned by nonphysicians. | 2010 | 4407829 | |
| [regional differences in the use of cholecystectomy in denmark during the period 1977-1985]. | in a register-based study of all cholecystectomized patients in denmark during the period from 1977-85 (37,048 patients) an account is given of the regional variations observed in connection with the intervention. the cholecystectomy operation is sub-divided into four types of operation dependent on whether the intervention is merely a matter of cholecystectomy or it involves the choledocus, the duodenum, the small intestine or other organs. the variation analysis is based on a division of the c ... | 2010 | 2919465 |
| paradoxical effect of respiration on ventricular rate in atrial fibrillation. | 1. in 50 subjects with atrial fibrillation we have attempted to demonstrate variation of ventricular rate with respiration, as evidence of cardioregulatory reflex activity. 2. the electrocardiogram was recorded for 3 min during spontaneous respiration. the presence of respiratory variation of r-r intervals was analysed by multiple regression against a cosine function (cosinor analysis), making it possible to determine the phase of respiration when the intervals were longest. 3. variation in vent ... | 2010 | 2920528 |
| the role of immunoglobulin e receptors in allergic diseases. | recent studies presented evidence that subpopulations of lymphocytes, monocytes and eosinophils carry immunoglobulin (ige)-specific membrane receptors which differ from the classical fc epsilon-receptors on basophil granulocytes and mast cells. the analysis of ige-receptor interactions with various cells has led to important insights as to the requirements of ige-antibody regulations. in addition, the membrane biochemical mechanisms in the induction of mediator release became better understood. ... | 2010 | 2937412 |
| [the behavior of 1,4-benzodiazepine drugs in acidic media. ix. effect of hydrolyzate of flutazolam on the central nervous system]. | 2010 | 2894449 | |
| diurnal variations in pain perception and thermal sensitivity. | pain and thermal sensitivity thresholds in healthy volunteers were examined for diurnal variations. the subjects were 11 men aged between 22 and 27 years (means = 23.5, s.d. = 1.5). data were collected for 2 days, with 7 measurements per day. to ensure the pain specificity of the results the subliminal modality, i.e., thermal sensitivity thresholds to warm and cold stimuli, was investigated in addition to the threshold for perception of heat pain. assessments were made on the right hand and foot ... | 2010 | 2919090 |
| aids estimates. | 2010 | 2916352 | |
| neuron-specific enolase in the diagnosis of small-cell lung cancer with pleural effusion: a negative report. | we measured the concentration of neuron-specific enolase (nse) and carcinoembryonic antigen (cea) in the serum and pleural fluid of 53 patients with pleural effusions, including seven patients with small-cell lung cancer (sclc). high levels (above 12.5 micrograms.l-1) of nse in pleural fluid were observed in five patients with sclc (sensitivity 71%). however, pleural fluid nse levels were also increased in five patients with other types of cancer and in four patients with non-malignant inflammat ... | 2010 | 2853080 |
| transfer of pre-embryos donated and fertilized in vivo to recipients given a steroid replacement therapy. | this study describes eleven procedures of non-surgical recovery of preimplantation conceptuses from the uteri of eight fertile donor women and the transfer of the recovered pre-embryos into the uteri of infertile recipients with primary ovarian failure, or with hypothalamic--pituitary failure. conjugated oestrogens and progesterone were administered to recipients as replacement steroids during the first 20 weeks of pregnancy, in order to produce a secretory endometrium allowing nidation and deve ... | 2010 | 2851614 |
| [bundle nailing--an evaluation after 27 years]. | the development of modern osteosynthetic procedures has made the use of bundle nailing uncommon. bundle nailing is restricted to extraordinary situations, but when indication is correct, it is superior to alternative procedures. from a current viewpoint only two indications remain: one are the fractures of the humeral shaft which cannot be treated conservatively, and the second are fractures of the femur in children if serious complications endanger conservative treatment. simple instruments and ... | 2010 | 2900592 |
| metastasis of an occult gastric carcinoma suggesting growth of a prolactinoma during bromocriptine therapy: a case report with a review of the literature. | the treatment of a slowly growing invasive prolactinoma with bromocriptine for 8 months resulted in a substantial decrease in plasma prolactin levels despite rapid suprasellar tumor expansion. on exploration, this uncommon observation could be attributed to hematogenous metastasis from an occult gastric adenocarcinoma to the pituitary tumor. apart from infiltration of neighboring parts of the hypothalamus, autopsy revealed no other hematogenous metastases. this extraordinary type of neoplasm-to- ... | 2010 | 2989726 |
| snake bite in pregnancy. | 2010 | 2863717 | |
| liposomes as membrane model for study of lipid peroxidation. | this article describes the properties, production and characterization of liposomes with special reference to their use as membrane model for the study of lipid peroxidation. it presents briefly the methods that can be used for the assay of liposomal lipid peroxidation and brings out the special advantages these liposomes provide in elucidating the mechanism of lipid peroxidation by different physical and chemical agents. studies involving liposomal lipid peroxidation by different agents and the ... | 2010 | 2830175 |
| generation of electronically excited species during enzymatic oxidation of chlorpromazine and related compound. | chemiluminescence in visible region was detected, during peroxidase-catalyzed oxidation of chlorpromazine at ph7.5 (but not at ph4.25) or of propericiazine, both at ph7.5 and at ph4.25. red colored intermediates, cation radicals, were produced and decayed in all enzymatic systems used. chemiluminescence was also detected at ph7.5, but not at ph4.25, when synthesized cation radical of chlorpromazine in water was mixed with concentrated buffer. protonation of alkyl nitrogen in the cation radical o ... | 2010 | 2862870 |
| sodium absorption. | 2010 | 2830324 | |
| [professionals in health areas: knowledge of the documentation terminology]. | 2010 | 3249908 | |
| functional significance of the kunitz-type inhibitory domains of lipoprotein-associated coagulation inhibitor. | blood coagulation can be initiated when factor vii or viia, a plasma protease, binds to its essential cofactor, tissue factor (tf), and proteolytically activates factors ix and x, triggering a cascade of events which eventually leads to the formation of thrombin and a fibrin clot. plasma contains a lipoprotein-associated coagulation inhibitor (laci) which inhibits activated factor x (xa) directly and, in a xa-dependent way, inhibits vii(a)/tf activity, presumably by forming a quaternary xa/laci/ ... | 2010 | 2927510 |
| components of depression in attempted suicides. | 2010 | 4748966 | |
| rapid detection of cutaneous herpes simplex virus infection with the polymerase chain reaction. | a simple and specific method for detecting herpes simplex virus infection in routinely processed paraffin-embedded biopsy specimens is described. dna is extracted from paraffin blocks, and subjected to dna amplification with the polymerase chain reaction. after 40 rounds, an amplified band can be detected after agarose gel electrophoresis and ethidium bromide staining. this band is specific for herpes simplex virus, because tissues infected with related viruses do not give this amplified band. w ... | 2010 | 2918243 |
| tardive dyskinesia. | 2010 | 2892565 | |
| safety and efficacy of estrace (micronized 17 beta-estradiol). | 2010 | 2906339 | |
| [atypical variant of cushing's syndrome]. | 2010 | 2897495 | |
| [biochemical aspect in cardiac ischemia--ischemic changes and reperfusion injury]. | 2010 | 2838873 | |
| carbohydrate structures of nonspecific cross-reacting antigen-2, a glycoprotein purified from meconium as an antigen cross-reacting with anticarcinoembryonic antigen antibody. occurrence of complex-type sugar chains with the gal beta 1----3glcnac beta 1----3gal beta 1----4glcnac beta 1----outer chains. | nonspecific cross-reacting antigen-2 (nca-2) is a glycoprotein purified from meconium as a closely correlated entity with carcinoembryonic antigen (cea). as in the case of cea, only asparagine-linked sugar chains are included in nca-2. in order to elucidate the structural characteristics of the sugar chains of nca-2, they were quantitatively released from the polypeptide backbone by hydrazinolysis and reduced with nab3h4 after n-acetylation. the radioactive oligosaccharides were fractionated by ... | 2010 | 2808357 |
| technique for measurement of one-dimensional instantaneous ablation velocity. | an oscillating mirror scanned a he-ne laser beam along the length of a thin rod while the rod was ablated by an argon laser beam. the shadow of the scanning beam on an image plane provides a picture of the instantaneous ablation velocity of the rod. this configuration provides a unique method for investigating one-dimensional ablation. | 2010 | 2976448 |
| dental implications of pharmacological management of the alzheimer's patient. | 2010 | 2975266 | |
| [surgical therapy of prenatally detected abdominal abnormalities]. | 2010 | 3042547 | |
| [surgical therapy of prenatally detected abdominal abnormalities]. | 2010 | 3042547 | |
| [behavior of iron complexes with nucleotides in erythrocytes in the course of blood preservation]. | 2010 | 4671501 | |
| [flexion-distraction injuries of the thoracolumbar spine with complete pancreatic rupture. description of a case]. | a case is reported of an unstable fracture dislocation of the thoracolumbar vertebral column combined with complete rupture of the pancreas. this combination of injuries is rarely encountered but is dangerous in severely injured patients. rapid and decisive operative treatment of both injuries should be performed, whereby adequate treatment of the pancreatic rupture has the highest priority. | 2010 | 2916133 |
| dysplastic nevi. markers for increased risk for melanoma. | a total of 452 white patients, classified into four dysplastic nevi groups, were followed prospectively by repetitive, complete cutaneous examinations using total-body photographs taken on entry into the study. sixteen patients (3.5%) developed 18 newly diagnosed malignant melanomas (mm) during an average follow-up period of 27 months. twelve of the 18 mm were in situ, and all of the six primary invasive mm diagnosed prospectively in this follow-up were less than 0.89 mm in breslow thickness, im ... | 2010 | 2910446 |
| [nutrition in the etiology of breast cancer. results of a survey in austria]. | 2010 | 2934651 | |
| dual action of excitatory amino acids on the metabolism of inositol phosphates in striatal neurons. | glutamate is able to stimulate inositol phosphate (ip) formation in striatal neurons in primary culture, mainly via an excitatory amino acid receptor of the quisqualate subtype. in the present study we show that carbachol (carb)-(a cholinergic agonist), but not neurotensin or norepinephrine-induced ip production could be reduced by 40% when measured in the presence of glu. the inhibition of the carb response by glu was dose dependent and reproduced by n-methyl-d-aspartate (nmda). quisqualate eli ... | 2010 | 2890092 |
| rural health care in the developing world. | 2010 | 2857377 | |
| a variant of mucolipidosis. ii. clinical, biochemical and pathological investigations. | we present in this paper a patient with a clinically intermediate form of mucolipidosis (ml). lysosomal hydrolase activity in fibroblasts was normal and levels of these enzymes in culture media were not elevated. there was a striking elevation of several hydrolases in serum and a deficiency (15% of normal) of n-acetyl-glucosamine phosphotransferase in fibroblasts. atypical electron microscopic findings were also observed. there was no evidence of increased synthesis, slower turnover, unbalanced ... | 2010 | 2839346 |
| epidemiological aspects of tardive dyskinesia. | although there continues to be some debate as to the extent to which neuroleptic drug treatment is either necessary or sufficient to produce abnormal involuntary movements in various psychiatric populations, the consensus at present is that neuroleptics do play a major role in producing, precipitating or evoking abnormal involuntary movements. no doubt a variety of other factors play a critical role in predisposing particular individuals to the development of the condition. numerous prevalence s ... | 2010 | 3063513 |
| [tecto-thalamo-telencephalic visual system of the brain in 13-day-old chick embryos]. | light and electron microscopic studies have been made of the nervous tissue in three parts of the tecto-thalamo-telencephalic visual system--i.e. tectum opticum, nucleus rotundus of thalamus and ectostriatum of telencephalon--of 13-day chick embryos. neuroblasts and neurones at various stages of differentiation were described together with various types of synaptic and nonsynaptic intercellular contacts in the neuropil of these brain structures. heterochronous maturation of these parts of the vi ... | 2010 | 3051806 |
| [pathogenetic aspects of schönlein-henoch disease]. | 2010 | 2940752 | |
| multiple gamma radiation sterilization of polyester fibres. | gamma radiation with a dose of 2.5 mrad has been found to be suitable to sterilize polyethylene terephthalate (pet) bulk materials intended for biomedical applications. the radiation stability of pet bulk materials and fibre may not however be taken as identical due to the changes in the polymer structure during the processing of bulk materials for fibre. the chemical changes occurring in pet fibres during single and multiple (prolonged) sterilization in air were investigated. it was found that ... | 2010 | 2975186 |
| hyperresponsiveness to water immersion in sodium retaining cirrhotics: the role of atrial natriuretic factor. | cirrhotics do not respond uniformly to head-out water immersion (hwi). some cirrhotics have an exaggerated natriuresis while others are unresponsive. we studied the humoral and urinary responses to hwi in 5 cirrhotics and compared this to 5 normals on the same 20 mm sodium intake. these cirrhotics had a documented tendency to salt and water retention but had minimal or no evidence of significant ascites. plasma levels of atrial natriuretic factor (anf) increased during immersion in both groups. ... | 2010 | 2976331 |
| arm exercise testing for coronary artery disease in patients with peripheral vascular disease. | we evaluated 74 peripheral vascular disease (pvd) patients (54 men, age 61 +/- 7 years and 17 women, age 63 +/- 7 years) for potential coronary heart disease (cad) using an arm exercise test (aet) protocol. all patients performed upright two-arm cranking using discontinuous stages of 2 minutes of exercise separated by 2 minutes of rest. exercise intensity was increased by +100 or 200 kpm (kilopond meters) with each stage. ecg was monitored continuously and blood pressure and 12-lead ecg tracings ... | 2010 | 2894261 |
| multiple small papular seborrheic keratosis. | 2010 | 2976363 | |
| leads from the mmwr. measles prevention: supplementary statement. | 2010 | 2913378 | |
| [various factors affecting the level of detection of schizophrenics]. | having studied the population of the schizophrenic patients registered at the psychoneurological dispensary of samarkand (n = 678) the authors have revealed that the identification of patients depends on both age/sex structure of the general population and the educational level. it has been found that underdetection of schizophrenics in samarkand is mainly accounted for by favourable cases of schizophrenia in particular in the following social groups: in young people under 19 years; in people wi ... | 2010 | 2950691 |
| initiation of swimming activity by trigger neurons in the leech subesophageal ganglion. iii. sensory inputs to tr1 and tr2. | in papers i and ii of this series, we described two pairs of interneurons, tr1 and tr2, in the leech subesophageal ganglion which can trigger swimming activity in the isolated central nervous system (cns). in this paper, we describe sensory inputs to these trigger neurons from previously identified mechanosensory neurons. we found that: weak mechanical stimulation (stroking) of a body wall flap attached to a segmental ganglion in an otherwise isolated cns excites the contralateral tr1 slightly. ... | 2010 | 3023604 |
| internal medicine in the national resident matching program 1978-1989. | 2010 | 2930105 | |
| [hemorrhagic fever with renal syndrome. a survey of zoonosis]. | 2010 | 2876539 | |
| domestic chlorine poisoning. | 2010 | 2863507 | |
| congenital adrenal hyperplasia. | 2010 | 2887945 | |
| immunogenetics of graves' ophthalmopathy. | we have performed an immunogenetic analysis of 53 patients with severe graves' ophthalmopathy, 51 patients with graves' disease but little or no clinically apparent eye disease, and 90 controls. the distribution of restriction fragment length polymorphisms was analysed in the three groups, using probes for the hla-dq alpha and dr beta regions, the t-cell receptor c alpha, v alpha, c beta and j gamma genes and the immunoglobulin gene switch regions, s alpha and s mu. there was no abnormal distrib ... | 2010 | 2908181 |
| investigation of the substrate binding and phosphate transfer in adenylate kinase by molecular mechanics. | molecular mechanics calculations of adenylate kinase (adk) complexed with atp, amp, and mg2+ have been carried out with three different model-built geometries. the lowest energy structure is that inferred from the x-ray structure, but such a geometry is not as consistent with the inference of an noe contact between his36 and the atp c2-h proton as the model of the second lowest energy. we have used the latter structure as a basis for modeling the reaction amp + atp----2adp in the presence of mg2 ... | 2010 | 2840275 |
| issues affecting the future of dentistry. | 2010 | 2797616 | |
| the student health center: a unique clinical experience for nursing leadership students. | 2010 | 3035135 | |
| immunosuppressive effects of blood transfusion in anaesthesia and surgery. | the immunosuppressive effects of blood transfusion at surgical operations become manifest as enhanced graft survival, increased cancer recurrence and decreased patient survival, and increased susceptibility to postoperative infections. blood transfusion in transplant recipients no longer offers this advantage when cyclosporine a is used. the deleterious effects of blood transfusion on the prognosis of some cancers found in the statistical analyses of retrospective studies are considered to be of ... | 2010 | 3067486 |
| immunosuppressive effects of blood transfusion in anaesthesia and surgery. | the immunosuppressive effects of blood transfusion at surgical operations become manifest as enhanced graft survival, increased cancer recurrence and decreased patient survival, and increased susceptibility to postoperative infections. blood transfusion in transplant recipients no longer offers this advantage when cyclosporine a is used. the deleterious effects of blood transfusion on the prognosis of some cancers found in the statistical analyses of retrospective studies are considered to be of ... | 2010 | 3067486 |
| role of glutathione in protecting endothelial cells against hydrogen peroxide oxidant injury. | to determine the mechanism responsible for the enhanced susceptibility of endothelial cells to oxidant injury in the absence of glucose, we induced endothelial cell injury with oxygen radicals in the presence of various oxygen radical scavengers and measured endothelial cell levels of glutathione after oxidant injury in the presence and absence of glucose. endothelial cells were damaged with toxic oxygen radicals generated by phorbol myristate acetate (pma)-activated polymorphonuclear leukocytes ... | 2010 | 3091744 |
| an antitumor polypeptide antibiotic neocarzinostatin: the mode of apo-protein--chromophore interaction. | the mode of neocarzinostatin-chromophore (ncs-chr)-apo-neocarzinostatin (apo-ncs) interaction in neocarzinostatin (ncs) complex has been described. the ncs-chr release from the ncs complex in the presence of various reagents, which destroy the high-order structure of the protein under various ph conditions, was examined. we found that (i) sodium dodecylsulfate, nonidet p 40, 8 m urea, and 2-propanol did release ncs-chr from ncs, (ii) no ncs-chr release is detected below ph 7, but it is enhanced ... | 2010 | 2967272 |
| effect of isotretinoin on survival of patients with myelodysplastic syndrome. | 2010 | 2884408 | |
| nmr contrast agents for proton imaging. | 2010 | 2832350 | |
| [personal experience in the diagnosis and therapy of boerhaave's syndrome]. | at the surgical clinic of the faculty hospital in hradec králové during the last 20 years 32 patients with perforation of the oesophagus were treated. of these five had a spontaneous rupture of the oesophagus--boerhaave's syndrome. the authors describe their own experience with the diagnosis of this syndrome. they emphasize the importance of early diagnosis which determines the type of surgical treatment, makes a more radical operation possible, reduces the percentage of complications and thus a ... | 2010 | 2799554 |
| aids out of the closet. | 2010 | 2830567 | |
| [non-enzymatic protein glycosylation and its clinico-biological significance]. | 2010 | 2798209 | |
| ternary representation of trivariate data. | a new fast trivariate display technique based on the ratio of three measured variables and of relative cell number, obtained from flow cytometric measurements, is described. | 2010 | 2917477 |
| [biological functions and time--the loose coupling mechanism of molecular machines]. | 2010 | 2934765 | |
| knowledge about suicide as a function of experience. | 2010 | 2928057 | |
| the mmpi and psychological factors in chronic low back pain: a review. | the minnesota multiphasic personality inventory (mmpi) is widely used in the psychological assessment of patients with chronic low back pain (lbp). patients' profiles have been used in a number of ways: in attempts to discriminate between cases; as predictors of both medical treatment and pain management program outcomes; and in attempts to assess degree of disability. studies reviewed here indicate that the concept of psychological etiology of chronic lbp, despite widespread use, has failed to ... | 2010 | 2950363 |
| misunderstanding possible in scope of work. | 2010 | 2922197 | |
| ceftriaxone resistant shigella flexneri, an emerging problem. | shigellosis is a disease of public health importance in developing countries. it may cause self-limited diarrhea to severe dysentery. emergence of multi drug resistant (mdr) strains is a growing concern globally. ceftriaxone and ciprofloxacin are the drugs of choice for mdr cases. here, we report a case of mdr shigella flexneri from an immunocompromised patient. the strain was resistant to ceftriaxone [minimum inhibitory concentration (mic) ≥ 64 μg/ml], limiting the treatment option. simultaneou ... | 2010 | 21258157 |
| [endodontic approach to injured teeth]. | 2010 | 2897345 | |
| a novel antisense rna regulates at transcriptional level the virulence gene icsa of shigella flexneri. | the virulence gene icsa of shigella flexneri encodes an invasion protein crucial for host colonization by pathogenic bacteria. within the intergenic region vira-icsa, we have discovered a new gene that encodes a non-translated antisense rna (named rnag), transcribed in cis on the complementary strand of icsa. in vitro transcription assays show that rnag promotes premature termination of transcription of icsa mrna. transcriptional inhibition is also observed in vivo by monitoring the expression p ... | 2010 | 20129941 |
| innate immune detection of the type iii secretion apparatus through the nlrc4 inflammasome. | the mammalian innate immune system uses toll-like receptors (tlrs) and nod-lrrs (nlrs) to detect microbial components during infection. often these molecules work in concert; for example, the tlrs can stimulate the production of the proforms of the cytokines il-1beta and il-18, whereas certain nlrs trigger their subsequent proteolytic processing via caspase 1. gram-negative bacteria use type iii secretion systems (t3ss) to deliver virulence factors to the cytosol of host cells, where they modula ... | 2010 | 20133635 |
| crystal structure of the dna-recognition component of the bacterial virus sf6 genome-packaging machine. | in herpesviruses and many bacterial viruses, genome-packaging is a precisely mediated process fulfilled by a virally encoded molecular machine called terminase that consists of two protein components: a dna-recognition component that defines the specificity for packaged dna, and a catalytic component that provides energy for the packaging reaction by hydrolyzing atp. the terminase docks onto the portal protein complex embedded in a single vertex of a preformed viral protein shell called procapsi ... | 2010 | 20133842 |
| a repulsive electrostatic mechanism for protein export through the type iii secretion apparatus. | many gram-negative bacteria initiate infections by injecting effector proteins into host cells through the type iii secretion apparatus, which is comprised of a basal body, a needle, and a tip. the needle channel is formed by the assembly of a single needle protein. to explore the export mechanisms of mxih needle protein through the needle of shigella flexneri, an essential step during needle assembly, we have performed steered molecular dynamics simulations in implicit solvent. the trajectories ... | 2010 | 20141759 |
| structural and functional divergence of the newly identified gtric from its gtr family of conserved shigella flexneri serotype-converting glucosyltransferases. | glucosyltransferases (gtrs) and o-acetyltransferase (oac) are integral membrane proteins embedded within the cytoplasmic membrane of shigella flexneri. gtrs and oac are responsible for unidirectional host serotype conversion by altering the epitopic properties of the bacterial surface lipopolysaccharide (lps) o-antigen. in this study, we present the membrane topology of a recently recognized gtr, gtric, which is known to mediate s. flenxeri serotype switching from 1a to 1c. the gtric topology is ... | 2010 | 20095950 |
| bacterial guanine nucleotide exchange factors sope-like and wxxxe effectors. | subversion of rho family small gtpases, which control actin dynamics, is a common infection strategy used by bacterial pathogens. in particular, salmonella enterica serovar typhimurium, shigella flexneri, enteropathogenic escherichia coli (epec), and enterohemorrhagic escherichia coli (ehec) translocate type iii secretion system (t3ss) effector proteins to modulate the rho gtpases rhoa, cdc42, and rac1, which trigger formation of stress fibers, filopodia, and lamellipodia/ruffles, respectively. ... | 2010 | 20123714 |
| transcriptional profile of the shigella flexneri response to an alkaloid: berberine. | berberine, a natural isoquinoline alkaloid found in many medicinal herbs, has been shown to be active against a variety of microbial infections. to examine the potential effects of berberine on shigella flexneri, a whole-genome dna microarray was constructed and a transcriptome analysis of the cellular responses of s. flexneri when exposed to berberine chloride (bc) was performed. our data revealed that bc upregulated a group of genes involved in dna replication, repair and division. intriguingl ... | 2010 | 20030725 |
| age-related efficacy of shigella o-specific polysaccharide conjugates in 1-4-year-old israeli children. | despite its high worldwide morbidity and mortality, there is yet no licensed vaccine for shigellosis. we reported the safety and immunogenicity of shigella o-specific polysaccharide-protein conjugates in adults and young children and efficacy of shigella sonnei conjugate in young adults. | 2010 | 20056180 |