Publications

aspergillosis of the frontal sinus.	aspergillus is the most common fungal infection of the paranasal sinuses and usually appears as a chronic disease in an otherwise healthy person. previously reported cases have involved the maxillary sinus alone in the majority of cases. to my knowledge, isolated frontal sinus aspergillosis has not been previously reported. a frontal osteoplastic flap approach was used to expose a fungus ball in the right frontal sinus of a healthy 69-year-old man. histologic preparations and fungal cultures sho ...	1978	343775
infection in the renal transplant patient.		1978	344880
examination of the immunoglobulin classes involved in the serological response of pregnant sheep to aspergillus fumigatus.	pregnant sheep inoculated with aspergillus fumigatus conidia developed agglutinating and precipitating antibodies for mycelial antigens. the agglutinins were initially exclusively of the igm class, but were later supplemented by igg antibodies, although igm production was usually sustained throughout the serological response. precipitins active in the immunodiffusion test were of the igg class. they developed later in the immune response than agglutinins and declined more rapidly. the precipitin ...	1978	345491
[comparison of radioimmunoassay techniques in the detection of ige and igg antibody activity against aspergillus fumigatus antigens].		1978	342606
antigens and hypersensitivity pneumonitis.		1978	147280
mycological and serological studies in the diagnosis of various forms of pulmonary aspergillosis.		1978	98837
[infectious causes of perinatal mortalities in ruminants (author's transl)].	the advantages and disadvantages of the different diagnostic techniques e.g. pathological and microbiological studies, immunoglobulin and specific antibody determinations and fluorescent antibody studies in relation to these mortalities are discussed. the most important pathological lesions in the placentas and foetuses are described.	1978	215769
aspergillus fumigatus epidural abscess in a renal transplant recipient.	an epidural abscess caused by aspergillus fumigatus occurred in a recipient of a cadaveric, renal allograft. the patient had persistent back pain and a peripheral neuropathy that involved the lower extremities. signs of spinal cord compression evolved. no definite portal of entry was found. diagnosis was made by histologic examination and culture of a biopsy specimen. therapy, consisting of aggressive surgical debridement, intravenous amphotericin b, and oral flucytosine was unsuccessful in erad ...	1978	339864
characterization of antigens from aspergillus fumigatus. i. preparation of antigens from organisms grown in completely synthetic medium.	aspergillus fumigatus was found to grow well in completely synthetic asparagine glycerol medium. four-day-old mycelia were totally disrupted by vigorous mechanical shaking with 0.45-micrometer glass beads. such mechanically produced extracts contained at least 52 precipitating antigens. the number of protein and carbohydrate components was maximal in 4-day-old organisms and decreased in older cultures. conversely, the number of components in culture filtrates increased with longer incubation per ...	1978	101103
characterization of antigens from aspergillus fumigatus. ii. fractionation and electrophoretic, immunologic, and biologic activity.	mycelial extracts of aspergillus fumigatus grown in completely synthetic medium were fractionated by precipitation with ammonium sulfate, by ion-exchange chromatography, and by gel filtration. the fractions were characterized chemically, by analytic polyacrylamide gel electrophoresis, and by tests for serologic and biologic activity. the distribution of the antigens in the fractions was determined by double diffusion in gel and fused-rocket immunoelectrophoresis. activity greater than that of th ...	1978	101104
determination of the minimal inhibitory concentration of amphotericin b and miconazole for 21 strains of aspergillus.	the susceptibility of 21 strains of aspergillus (11 of a. fumigatus, 8 of a, niger, and 2 of a. flavus) isolated from human pathologic specimens to amphotericin b and miconazole has been comparatively studied. determination of the minimal inhibitory concentration of both drugs in a liquid medium showed a noticeably variability for the different strains. the values obtained for amphotericin b varied between 0.25 microgram/ml (2 strains) and 1.25 microgram/ml (5 strains) after 48 hours, and betwee ...	1978	104180
a comparative study of antigens of aspergillus fumigatus isolates from patients and soil of ornamental plants in the immunodiffusion test.	the strikingly frequent and constant presence of aspergillus fimigatus in the soil of potted ornamental plants kept in private houses and hospitals has been the reason for studying the antigens of the strains found from the diagnostic and epidemiological angles. culture-filtrate antigens of a. fumigatus strains isolated from the soil of 4 different ornamental plants, epiphyllum (epiphyllum truncatum), orange tree (citrus sinensis), alpine rose (azalea indica) and christmas flower (euphorbia pulc ...	1978	83753
[process of fumigatin and spinulosin formation by aspergillus fumigatus fres and polarographic assay of these toxins (author's transl)].	a strain of aspergillus fumigatus (fresenius) isolated from a milk food for calves was grown on a culture medium containing added saccharose. the purpose was to study the synthesis of two recently discovered mycotoxins, fumigatin and spinulosin. the work was performed under many different conditions of temperature, ph and inoculum. these mycotoxins were measured by analytical differential pulse polarography. correlations were observed between the growth rate of a. fumigatus and variation in ph o ...	1978	31124
variability of antigenicity of aspergillus fumigatus.		1978	75900
occupational hypersensitivity lung disease.	a case of occupational hypersensitivity pneumonitis caused by an air conditioning unit is presented. aspergillus fumigatus and aureobasidium pullulans were cultured from this unit and antibodies to these organisms were found the patient's blood. the case shows that this disease may present in a very subtle form and may be diagnosed by a culture from the patient's environment and an easily performed blood precipitin test. the importance of searching for this type of lung disease and the need for ...	1978	569690
characterization of antigens from aspergillus fumigatus. iii. comparison of antigenic relationships of clinically important aspergilli.	antigenic relationships between strains of aspergillus fumigatus, aspergillus fumigatus var. elipticus, aspergillus phialiseptus, aspergillus flavus, and aspergillus niger were analyzed by fused rocket immunoelectrophoresis and by skin tests. seventy-three to 89 % of the numbers of antigens detected between strains and species of the a. fumigatus series were shared. the degree of sharing between antigens of a. flavus, a. fumigatus series, and a. niger was much lower and ranged from 19 to 35 %. i ...	1979	92906
glucose and phosphorus utilization by two dermatophytes.	trichophyton mentagrophytes and aspergillus fumigatus dissimilated glucose through emp pathway. oxygen and inorganic phosphorus were found to control the rate and extent of glucose metabolism.	1979	94752
invasive aspergillosis in acute leukemia: correlation with nose cultures and antibiotic use.	aspergillosis in cancer patients is a problem. because not all patients can undergo invasive procedures, we sought other methods for diagnosis. we reviewed the data from all patients with acute nonlymphocytic leukemia treated at our center during a 3-year period. of 125 patients, 18 had invasive aspergillosis (cases). eleven patients had nose cultures growing aspergillus flavus or a. fumigatus; 10 of these 11 had aspergillosis, whereas only eight of 114 without such nose cultures had invasive di ...	1979	105657
filtering hospital air decreases aspergillus spore counts.	we performed counts of airborne spores in a hospital with filtered air where a decrease in nosocomial infection with aspergillus organisms had been documented. for comparison, similar studies were performed at a nearby general hospital in a ward with open windows. the total spore count inside the hospital with filtered air was significantly less than inside the ward with open windows. the total count of aspergillus organisms in the filtered air was significantly less than that in the room with o ...	1979	109022
enzyme linked immunosorbent assay (elisa) for igg and ige antibodies to protein and polysaccharide antigens of aspergillus fumigatus.	elisa has emerged as a useful alternative to other more costly and complex tests. polystyrene microhaemagglutination plates have been used as solid phase to absorb aspergillus fumigatus protein and polysaccharide components for detection of specific antibodies in patients with various forms of pulmonary aspergillosis. igg and ige antibodies to the polysaccharide as well as the protein allergens have been found. for the ige test a double antibody technique has been developed, which is more sensit ...	1979	113131
the presence of precipitating antibodies in the sera of horses with chronic obstructive pulmonary disease (copd).	the sera of horses affected and not affected with chronic obstructive pulmonary disease (copd) were examined for precipitins to micropolyspora faeni and aspergillus fumigatus. precipitins to both antigens were not restricted to copd cases but occurred more frequently in animals affected with copd. many animals without detectable precipitins responded clinically to inhalation challenge with these antigens.	1979	114387
[electron microscopic aspects of opportunistic fungi after pretreatment].	the ultrastructive of aspergillus fumigatus, aspergillus flavus and aspergillus niger was studied when treated in vitro with 0.001, 0.01 and 0.1% econazole nitrate and econazole base. the very first morphological alterations appear faster than in normal-growing fungus and consist in a convoluted cytoplasmic membrane, large mesosomes and lomasomes and an extensive vacuolization. acid phosphatase is found in the mesosomes and lomasomes and also in the center of the vacuoles. this is an early sign ...	1979	114432
[saphrophytic life of opportunistic fungi].	probably all pathogenic fungi can cause opportunistic infections in compromised hosts. this paper briefly reviews our knowledge on the saprophytic life - geographic distribution and habitat - of the most common pathogenic fungi. some mycoses are of endogenous origin - e.g. candida albicans is an endosaprophyte - others of epigenon origin - e.g. pityrosporum ovale is an episaprophyte - but most mycoses are caused by fungi which have an exosaprophytic (or exosaprobic) life: one becomes infected af ...	1979	114433
[fungi in pulmonary pathology].	the author presents the most frequently observed pulmonary infections due to some opportunistic fungi (yeast, aspergillus, mucor). he describes the criterial for a correct diagnosis of pulmonary mycosis.	1979	114435
[changes in sperm ultrastructure of bulls with decreased sperm activity and freezability].	a decrease of sperm freezability occurred at the k. breeding station, and this situation lasted longer than a year. out of the 2550 ejaculates taken from 42 breeding bulls within 12 months, 685, i.e. 26.7%, were unfit for use immediately after sperm collection, mostly owing to a low activity of spermatozoa and pathological forms of their motility, and another 469 ejaculates, i. e. 18.3%, were unfit for use after sperm freezing; on the whole, 1154 (i. e. 45.2%) ejaculates had to be excluded. it w ...	1979	117588
[disseminated aspergillosis in a loon].	a case is described of generalized mycosis in a diver of the species gavia arctica, caused by the fungus aspergillus fumigatus. the organism of the bird was so much damaged that the bird died. there is a detailed description of the mycological characteristics of the invading agent and a description of the histopathological changes in the primarily affected organ -- the lungs. further, a survey is presented of the orders of freely living birds and birds in captivity in which aspergillosis has bee ...	1979	117594
characterization of antigens from aspergillus fumigatus. iv. evaluation of commercial and experimental preparations and fractions in the detection of antibody in aspergillosis.	commercially available preparations of aspergillus fumigatus, experimental extracts and fractions of a. fumigatus, and extracts of 5 other aspergilli were evaluated in a blind manner for their abilities to detect antibody in 66 serum specimens from patients with aspergilloma, allergic bronchopulmonary and invasive aspergillosis, and unconfirmed aspergillosis. rocket immunoelectrophoresis was more sensitive than immunodiffusion in 2 dimensions. although qualitative differences in antigen composit ...	1979	117731
[dynamics of immunological reactions in patients operated for aspergilloma].		1979	117881
role of aspergillus and candida species in allergic bronchopulmonary mycoses. a comparative study.	allergic bronchopulmonary aspergillosis (abpa) and allergic bronchopulmonary candidiasis (abpc) has been diagnosed in 20 and 13 cases respectively with one case in common, on the basis of laboratory and clinical findings. most of the abpa cases (60%) diagnosed had an early onset of respiratory symptoms, i.e. below the age of 30 years, while most of abpc cases (69%) had a late onset of respiratory symptoms, i.e. after the age of 30 years. the precipitin bands in abpa and abpc were r-type and h-ty ...	1979	118528
a solid-phase radioimmunoassay for the measurement of antibody to aspergillus in invasive aspergillosis.	a solid-phase radioimmunoassay (spria) to measure antibody responses to aspergillus fumigatus and aspergillus flavus antigens in invasive aspergillosis (ia) was developed and compared with immunodiffusion (id) and counterimmunoelectrophoresis (cie). spria detected significant elevations in levels of aspergillus antibody in 15 (79)% of 19 patients with ia. fewer patients with ia were positive by id (give of 19) or cie (four of 19). only seven )8%) of 58 subjects with other fungal or bacterial inf ...	1979	118999
aerometric study of viable fungus spores in an animal care facility.	studies of airborn fungi were undertaken to evaluate exposure risks for laboratory animals and human handlers which might lead to allergic or invasive disease. although sporadically high fungus levels were encountered, counts of viable fungus particles were in general low. recoveries on malt extract agar significantly exceeded those on sabouraud dextrose agar. the taxa most frequently and abundantly recovered were penicillium species. data analyses suggest that 'clean' bedding material may be th ...	1979	119110
[on the serodiagnosis of aspergillosis: comparison of various aspergillus extracts (author's transl)].		1979	121207
the preparation and chemical composition of fractions from aspergillus fumigatus wall and protoplasts possessing antigenic activity.	a detergent-soluble fraction was prepared from the fragmented wall of aspergillus fumigatus mycelium using the non-ionic detergent triton x-100, and a wall-free extract was prepared from the same source in the form of protoplasts, released by a lytic enzyme system from trichoderma harzianum. these extracts were examined by polyacrylamide gel electrophoresis and their detailed chemical composition was established. they were compared with the water-soluble fraction prepared from total mycelium, wh ...	1979	225408
simultaneous disseminated aspergillosis and zygomycosis in a leukemic patient.	although the incidence of fungal infections is increasing, infections caused by more than one fungus are rare. we have described the clinical, pathologic, and mycologic findings in a leukemic patient with simultaneous pulmonary infection and systemic dissemination caused by aspergillus fumigatus and rhizopus sp.	1979	290047
studies on the mode of action of 5-fluorocytosine in aspergillus species.	the mode of action of 5-fluorocytosine (5-fc) was studied in three isolates of pathogenic aspergillus with varying degrees of susceptibility to the drug. distribution studies showed that susceptibility or resistance to 5-fc was not dependent on uptake of the drug. while only a small percentage of the total 5-fc taken up was found in the rna fraction of the cells, most remained in the acid-soluble intracellular pool. 5-fc, 5-fluorouracil (5-fu) and 5-fluorodeoxyuridine monophosphate (5-fd-ump) we ...	1979	156110
[control of aspergillus fumigatus infections during a clinical stay].		1979	161380
[mycoses of the sinus].		1979	162345
immunodiagnosis of systemic aspergillosis. i. antigenemia detected by radioimmunoassay in experimental infection.	because systemic aspergillosis is difficult to diagnose ante mortem, a study to improve immunodiagnosis was undertaken in a rabbit model of disseminated infection. we found that the predominant humoral response of infected animals was directed against four aspergillus antigens identified by crossed immunoelectrophoresis. one of these antigens, a cell-wall carbohydrate, was purified by gel-filtration chromatography and was used to develop a radioimmunoassay. the sensitivity of this assay was incr ...	1979	366048
[aspergillosis of the nose and paranasal sinuses].		1979	390917
intradural extramedullary aspergilloma complicating chronic lymphatic leukaemia.		1979	391317
response to bronchial provocation and exercise in children with cystic fibrosis.	ten of fifteen cystic fibrosis children with positive skin prick tests to common antigens gave an immediate bronchial reaction to the antigen inhaled, five of them also gave a late reaction; however only one gave a history of asthma. the antigen most commonly eliciting a positive skin reaction in cystic fibrosis patients is aspergillus fumigatus. in six children tested to this antigen the bronchial response varied, two were negative, one gave an immediate reaction and three gave a dual (immediat ...	1979	391435
aspergillus fumigatus and lung disease.	the range of clinical presentations of lung diseases associated with aspergillus spp. is great. the conditions are very frequently misdiagnosed but errors should be avoided if the possibility of a fungal cause is considered and simple immunological tests undertaken. often no more than skin-prick tests and serum precipitins need to be done. in many cases, fungus is not isolated from the sputum and negative results do not exclude the possibility of a. fumigatus as the causal agent. treatment often ...	1979	392479
exposure of rabbits to spores of aspergillus fumigatus or penicillium sp: survival of fungi and microscopic changes in the respiratory and gastrointestinal tracts.	rabbits were exposed to spores of aspergillus fumigatus by 1 of 2 routes: exposure to aerosols of dry spores or introduction of liquid suspensions of spores directly into the stomach. rabbits also were exposed to aerosols containing spores of a penicillium sp. cultural and microscopic examinations of tissues from the respiratory and gastrointestinal tracts indicated fungi were distributed throughout the gastrointestinal tract of the rabbits within 1 hour after exposure to aerosols of a fumigatus ...	1979	393142
thermophilic and thermotolerant fungi in poultry droppings in nigeria.	ten species of fungi were obtained from poultry droppings in nigeria. six of these are true thermophiles while the other four are thermotolerant. aspergillus fumigatus fresenius, mucor pusillus lindt and thermoascus aurantiacus stolk are known human pathogens. except for m. pusillus, all the thermotolerant species had a higher occurrence at 45 degrees c while the thermophilic varieties were readily obtained at 50 degrees c.	1979	393797
[enzymolysis of the acidic hydrolysates of plant residues].		1979	393967
haemoptysis in eosinophilic granuloma.	eosinophilic granuloma of bone may involve the lung in about 20% of cases (lewis 1964); and may present in the lung without other organ involvement. haemoptysis occurs in about 10% of cases for unknown reasons. i document here a case with typical presentation and course, but which was complicated by haemoptysis of increasing severity leading to death. the cause of haemoptysis was diagnosed at fibreoptic bronchoscopy.	1979	394756
endogenous fungus endophthalmitis (probably aspergillus).	a 53-year-old organic chemist developed severe asthma and bronchitis a few weeks after professional exposure to plant dust. 15 days later an acute severe endophthalmitis occurred. both the systemic and eye conditions were treated with corticosteroids and antibiotics. the atrophic eye which was enucleated 6 months later histologically revealed abscesses in the iris, ciliary body, lens and vitreous harbouring numerous islands of septate, dichotomously branching hyphae, orientated in the same direc ...	1979	395478
[results of local treatment of pleural aspergillosis].		1979	395511
isolation of some new tryptoquivaline-related metabolites from aspergillus fumigatus.		1979	396046
investigation of the hemolytic site of asp-hemolysin.		1979	396392
the effect of beta-glucuronidase and chitinase on the cell wall of aspergillus niger and aspergillus fumigatus.	the effects of beta-glucuronidase and chitinase have been tested on the hydrolysis of the cell walls of the economically important fungi, aspergillus niger and aspergillus fumigatus. the extent of wall hydrolysis was measured by assaying for total reducing sugars, n-acetyl sugars and protoplast production. maximum reducing sugar release was attained after 40 min incubation, both with beta-glucuronidase supplemented with chitinase and beta-glucuronidase alone, whereas n-acetyl sugar release reach ...	1979	396451
a guide to the recent literature on aspergillosis as caused by aspergillus fumigatus, a fungus frequently found in self-heating organic matter.	spores of aspergillus fumigatus have been found to be abundantly present in the outdoor air at a site where large scale experimental composting of sewage sludge is in progress at beltsville, maryland. the health significance of this finding, for that site and for others in the future, is still only incompletely understood. further studies are in progress to characterize absolute concentrations of the spores of the fungus in air at the site, spore dispersal by air from composting operations, and ...	1979	396477
[pulmonary atelectasis caused by bronchocentric aspergillosis: an other farmer's pneumoconiosis].		1979	396705
germination of non-irradiated and gamma-irradiated fungal spores on water agar and natural soil.	germination and germ-tube lengths of non-irradiated and gamma-irradiated spores of eight soil fungi were studied on water agar and on natural soil. non-irradiated spores showed variable degrees of sensitivity to the fungistatic factor in natural soil. lower doses of gamma-irradiation (5 k rad) produced stimulus to germination and germ-tube lengths without losing the fungistatic properties of the fungi concerned. germination at the rest of treatments (100 and 500 k rad) showed significant inhibit ...	1979	396932
structure-activity relationships in fusidic acid-type antibiotics.		1979	397741
[frequency of fungal infection in chronic bronchitis and bronchiectasis (author's transl)].	among 1 161 patients with chronic bronchitis and 172 patients with bronchiectasis treated for a longer time with antibiotics or with antibiotics and corticosteroids and examined all for fungi in bronchial secretion, 34 = 0.9% showed a secondary infection with fungi (32 candida, 2 aspergillus fumigatus).	1979	398098
inhaled beclomethasone dipropionate in allergic bronchopulmonary aspergillosis. report to the research committee of the british thoracic association.	a double-blind multi-centre study was carried out to assess the effects of beclomethasone dipropionate aerosol on the control of symptoms of asthma and on fungal colonization of the bronchi, in patients with allergic bronchopulmonary aspergillosis who had not been treated with an inhaled corticosteroid preparation for at least six months. each of the 32 patients who completed the trial was treated with beclomethasone (100 microgram four times daily) or placebo aerosol for consecutive periods of ...	1979	400108
[intracavitary inclusion].		1979	400278
prevalence of aspergillus and candida precipitins in renal dialysis and transplant patients.	serum precipitin tests to aspergillus and candida antigens were used to define the rate of infectivity with these fungal organisms in patients on renal dialysis and after kidney transplantation. a total of 58 studies in 53 consecutive patients, of whom 41.5% were post-transplant an average of 14.6 months, failed to detect significantly more precipitin activity than in a normal population. the specificity of this non-immunoreactivity was supported by the absence of clinical or post-mortem evidenc ...	1979	400842
humidifier-associated extrinsic allergic alveolitis.	three cases of allergic alveolitis due to indoor humdification systems are described. thermoactinomyces vulgaris precipitins were detected in the serum of a 37-year-old female patient who had typical febrile attacks during exposure to cool-mist from a home humidifier. when the cause was detected and eliminated, the symptoms and signs disappeared and the woman's gas transfer factor improved from 56% to normal within six months. in a printing office a 60-year-old woman had had febrile attacks with ...	1979	375386
demonstration of antigenemia by radioimmunoassay in rabbits experimentally infected with aspergillus.	antigens were detected in the blood of rabbits infected with aspergillus fumigatus by a solid-phase (tube) radioimmunoassay (ria). the radiolabel for the assay was a polysaccharide-rich alkali extract (apae) from the mycelia of a. fumigatus. before this extract could be suitable labeled with 125i, it had to be conjugated with tyramine. rabbits immunized with heat-killed mycelia had titers of antibody in serum of as high as 1:38,000 against this radiolabeled antigen. with unlabeled and unconjugat ...	1979	376756
allergic bronchopulmonary aspergillosis-like syndrome consequent to aspergilloma.	two patients who represent the first well-documented cases of an allergic bronchopulmonary aspergillosis-like syndrome developing consequent to an aspergilloma are reported. these patients experienced both subjective and objective evidence of improvement after the initiation of corticosteroid therapy. literature relevant to the combined occurrence of aspergilloma and allergic bronchopulmonary aspergillosis and their immunology is reviewed.	1979	378049
pulmonary infections by the fungus aspergillus.		1979	379325
[in vivo leukocyte migration in patients with chronic bronchitis and precipitating antibodies to aspergillus fumigatus antigen in the serum].		1979	380172
[detection of antibodies against aspergillus fumigatus. 1st report: making of antigens (author's transl)].	a method of antigen preparation from aspergillus fumigatus has been described. we received the antigens from medium and mycel used for the detection of precipitins and ige-antibodies. the antigenic components are demonstrated in the immunoelectrophoresis. by the use of absorption we did not find essential differences between medium antigen and mycel antigen for the detection of precipitins. the medium antigen recommended for diagnostic is easier to produce and, moreover, has advantages for the d ...	1979	380190
comparative susceptibility and effect of mild aspergillus fumigatus infection on three strains of chickens.	a single comb white leghorn strain (dryden x auburn = dax) was more susceptible to aspergillus fumigatus infection and suffered significantly greater mortality than the athens-canadian or a vantress x arbor-acres cross exposed soon after hatching. the unexposed controls of the three types weighed significantly more than the corresponding exposed survivors at 5 weeks of age.	1979	382171
[significance and diagnosis of fungal abortion in cattle].		1979	382703
incidence of immediate sensitivity to aspergillus fumigatus in a north american asthmatic population.	allergic bronchopulmonary aspergillosis might be less frequent in north america because the incidence of immediate sensitivity by asthmatics to a. fumigatus is less. in order to check this hypothesis, 200 asthmatics were skin tested with two extracts of a. fumigatus which had been shown to produce positive reactions in fifty patients who had allergic aspergillosis. of the asthmatics, 21.5% reacted to the commercial extract by prick testing and 39% by intradermal testing. using an extract kindly ...	1979	383312
galactomannan antigenemia in invasive aspergillosis.	galactomannan (gm) extracted from mycelia of aspergillus fumigatus with cold dilute alkali reacted with antiserum specific for an antigen that circulated in invasive aspergillosis in rabbits and humans. the gm was purified by its affinity for concanavalin a and was separated from a nonantigenic glucan by gel permeation on sephacryl s-200. the gm molecular weight of between 25,000 to 75,000 was smaller than the antigen present in infected rabbit serum which was retained by an ultrafiltration memb ...	1979	383620
serum ige antibodies in sudden infant death syndrome.		1979	383930
detection of circulating antigen of aspergillus fumigatus in sera of mice and rabbits by enzyme-linked immunosorbent assay.	circulating antigen of aspergillus fumigatus was demonstrated in the sera of experimentally infected, cortisone-treated mice and rabbits by enzyme-linked immunosorbent assay (micro-elisa), confirming earlier results where fungal antigen had been detected by counter-immunoelectrophoresis (cie). peaks of detection of circulating antigen by cie and micro-elisa in mice were not simultaneous suggesting that the nature of the predominant antigens may have altered during the course of infection. cie fa ...	1979	384254
cystic organizing pneumonia with elements of plasma cell granuloma.		1979	384960
chronic obstructive pulmonary disease (copd) in horses: aetiological studies: responses to intradermal and inhalation antigenic challenge.	micropolyspora faeni and aspergillus fumigatus were identified as common causes of respiratory hypersensitivity in horses affected with chronic obstructive pulmonary disease (copd). rye grass pollen and an actinomycete evoked respiratory allergy in a few horses. not infrequently, individual horses were found to have respiratory hypersensitivity to two or more antigens. the methods used to examine for allergy were intradermal testing and inhalation challenge with environmental antigens. an intrad ...	1979	385306
[fungal maxillary sinusitis].	since 1969, 600 patients suffering from maxillary sinusitis have been systematically controlled clinically as well as mycologically. we discovered 81 cases of maxillary sinusitis (13,4%). aspergillus fumigatus and candida albicans were the most frequently isolated fungi. three clinical forms could be distinguished: (1) a muco-purulent form (35 cases); (2) a budding and/or caseous form (22 cases), and (3) a pseudotumoral form (24 cases). 42 patients treated with a 1% econazol (base) solution wer ...	1979	385382
[experimental aspergillosis in mice].	the experimentally induced aspergillosis of mice is discussed as a useful parameter for the screening of new antimycotics. there are important differences between this test model and aspergillus infections in humans. mice must be infected intravenously with more than 10(6) spores of aspergillus fumigatus to provoke multiple abscess formation in the kidneys which induces an acute, lethal course of infection. intratracheal administration of 2 x 10(6) spores did not evoke any symptoms. the therapeu ...	1979	385383
management of pulmonary disorders caused by the inhalation of aspergillus spores.		1979	385573
[orbital aspergillosis--a contribution to its diagnosis and treatment (author's transl)].	in connection with a case report, the mycological diagnosis and treatment of orbital aspergillosis are reviewed. in a 59-year-old male patient an exophthalmus on the right side could be diagnosed as aspergillosis spreading from the corresponding sinus maxillaris into retro- and peri-orbicular regions, after other causes had been excluded by differential diagnosis. in a biopsy specimen from the retrobulbar tumor, a fungal granuloma was found which, histologically and by isolation of the fungus, c ...	1979	385968
effect of amphotericin b on the metabolism of aspergillus fumigatus.	action of amphotericin b on the growth and metabolism of aspergillus fumigatus has been investigated. the fungus proved to be very sensitive to amphotericin b, showing complete inhibition of growth at 0.5 units/ml. amphotericin b suppressed the exogenous and endogenous respiration and glycolysis of a. fumigatus as well as the assimilation of various glycolysis and tca cycle intermediates. addition of cations and cholesterol failed to reverse the action of amphotericin b. the treated mycelium rel ...	1979	386128
generalized aspergillosis showing a granulomatous pattern.	an autopsy case of a very rare form of generalized aspergillosis with a prominent granulomatous pattern simulating sarcoidosis was presented. the patient was a forty-year-old japanese female with a four years' clinical course. kveim's test was positive. multiple epithelioid cell granulomata as well as necrotizing and suppurative lesions were recognized in generalized lymph nodes, liver, epicardium, gall bladder, adrenals, kidneys and duodenal mucosa. fungal elements in the epithelioid cell granu ...	1979	386709
effects of fungicides on aspergillus fumigatus.	aspergillus fumigatus was the most frequently isolated thermophilous fungus from green leaf surfaces. the application of fungicides significantly reduced the frequency of its occurrence there. a. fumigatus was relatively tolerant to fungicides. on captan-, thiram-, and verdasan-treated leaves, a. fumigatus constituted 66%--80% of the total number of isolates obtained at 45 degrees c from each treatment while dicloran did not depress the percentages. at 45 degrees c, a. fumigatus was found to be ...	1979	386945
aspergillus in the lung.	there is an increasing incidence of deep mycotic infections. the initial clue to the diagnosis is often radiologic. it is important therefore for the radiologist to be aware of these infections and the setting in which they occur, e.g., allergic bronchopulmonary aspergillosis in the asthmatic person, invasive aspergilliosis in the immune compromised host, and aspergilloma in cavitary lung disease. in so doing he can alert the clinician to the possibility of a mycotic infection and thus initiate ...	1979	387671
[reactivity of peripheral blood granulocytes in aspergillus fumigatus infection].		1979	388880
non-specific potentiation of ige by parasitic infections in man.	infection with the helminthic parasites ascaris lumbricoides and/or necator americanus (hookworm) induces the production in man of high levels of serum ige. the specificity of this ige antibody when measured by rast to a wide range of allergens was restricted in general to the helminthic antigens. absorption of the sera with immunosorbents produced by coupling extracts of a. lumbricoides to cnbr activated sepharose 4b established that ascaris antigen specific ige antibodies contributed a minor f ...	1979	370030
acute allergic alveolitis.		1979	370393
[cases of aspergillus mastitis in cattle].		1979	373748
combined amphotericin b-flucytosine therapy in aspergillus pneumonia.	the incidence of aspergillosis is increasing while the prognosis remains dismal. standard single-drug therapy with amphotericin b offers unacceptably low cure rates. a patient with aspergillus pneumonia was treated with a synergistic combination of amphotericin b and flucytosine. a prompt clinical response and progressive resolution of the infection were observed. combination therapy appeared to decrease the dose of amphotericin b needed for effective therapy. it may provide improved results wit ...	1979	374761
[aspergillus endocarditis following aortic valve replacement].		1979	374821
transurethral passage of aspergillus fungus balls in acute myelocytic leukemia.	a patient with acute myelocytic leukemia who had a chronic febrile illness during the induction of remission of leukemia developed asymptomatic discrete pulmonary infiltrates which rapidly evolved into cavities containing homogeneous opacities. over the next five weeks, the cavities resolved without specific treatment. the patient subsequently passed large fungus balls in the urine, and the diagnosis of disseminated aspergillosis was made. a course of intravenous amphotericin b therapy was compl ...	1979	371013
allergy in cystic fibrosis.	forty-four patients with cystic fibrosis, sixty-seven parents, and thirty-nine controls were compared with regard to their immediate cutaneous hypersensitivity, total and specific serum ige and serum igg4 concentrations. the patients had increased prick test reactions and specific ige to aspergillus fumigatus. the development of reactions to a. fumigatus correlated with the severity of the disease. there were no other significant differences when serum total ige, specific ige and igg4 concentrat ...	1979	371883
acute disseminated aspergillosis during the neonatal period. report of an instance in a 14-day-old infant.	we describe an infant who died with extensive lesions of disseminated aspergillosis on the 18th day of postnatal life. aspergillus fumigatus was recovered from blood cultures. initial clinical manifestations were suggestive of hepatitis, and steroids and antibiotics were used in the treatment. this therapy may have fostered the onset of an opportunistic mycosis. advanced multisystemic aspergillotic lesions were seen at autopsy, especially prominent in lungs and gastrointestinal tract. the extent ...	1979	371889
characterization of subunits from fatty acid synthetase in fungi [proceedings].		1979	372037
invasive pulmonary aspergillosis associated with influenza.	fatal invasive pulmonary aspergillosis may follow viral influenza infections. two cases with verified influenza a infection were followed by fatal necrotizing pneumonia due to aspergillus fumigatus. both patients demonstrated cutaneous anergy and lymphocytopenia. influenza and perhaps other viruses that depress t-cell function may result in increased susceptibility to infections in which t cells are important in host defenses.	1979	372590
[evaluation of nonlyophilized and lyophilized metabolic antigens of aspergillus fumigatus using the precipitation test].		1979	368734
allergic bronchopulmonary aspergillosis in pediatric practice.	twelve cases of allergic bronchopulmonary aspergillosis in the pediatric age group are reported. the average age of diagnosis was 14.5 years with a range from 6 to 18 years. all patients had a history of pulmonary infiltrations or atelectasis or both documented by chest radiographs. eight patients had bronchograms or tomograms, and seven of them showed proximal bronchiectasis. total serum ige concentrations were elevated in all patients. preciptitating antibodies against aspergillus fumigatus we ...	1979	423017
evaluation of long term tobramycin therapy in patients with cystic fibrosis and advanced pulmonary disease.	to nine cystic fibrosis patients with chronic bronchopulmonary infection of severely damaged lungs invaded by pseudomonas aeruginosa, eleven courses of prolonged tobramycin treatment (5 mg/kg/day) for four to 16 weeks were administered. pulmonary symptoms improved and a better quality of life was achieved in all but one patient. objective parameters (chest x-ray, pulmonary function tests) changed to a lesser extent. in only one patient was pseudomonas eradicated from the sputum but reappeared af ...	1979	436850
toxigenic fungi isolated from roquefort cheese.	to evaluate the potential for mycotoxin production by fungi contaminating blue-veined cheese, as well as by the ripening fungus, penicillium roqueforti, the fungal flora of six of local and imported brands was determined. a total of 19 fungi were isolated from the six brands tested. fourteen of the isolates were toxic to chicken embryos. the toxigenic fungi produced the following mycotoxins: aspergillus fumigatus, kojic acid; a. versicolor, sterigmatocystin; penicillium roqueforti, penicillic ac ...	1979	440405
the occurrence and treatment of false positive reactions in enzyme-linked immunosorbent assays (elisa) for the presence of fungal antigens in clinical samples.	non-specific positive reactions have been revealed in enzyme-linked immunosorbent assays (elisa) of sera for the presence of fungal antigen. these false positives were recognized by their occurrence in tests for both candida albicans and aspergillus fumigatus antigens and by their response to dithiothreitol, combined with their reaction with non-immune rabbit globulin. a scheme is proposed which differentiates between true and false positive reactions. use of fractionated anti-fungal globulin in ...	1979	469266
fungus species isolated from commercial hatcheries in alabama.	selected locations (incubators, incubator rooms, hatchers, hatcher rooms, chick pools, and egg rooms) in six commercial broiler hatcheries in alabama were sampled for fungus species over a 12-month period (may 1977-april 1978) by open-plate techniques (cornmeal agar or sabouraud's dextrose agar). colonies at each location were counted at 24, 48, and 72-120 hours postexposure. thirty-five species representing 21 genera were identified. the most prevalent genera were cladosporium, penicillium, asp ...	1979	486003
an imidazole derivative (econazole) as an antifungal agent in cell culture systems.	econazole, an imidazole derivative, was tested as an antifungal agent in different cell culture systems. in comparison with fungizone, econazole has the following advantageous properties: higher stability, higher solubility, better antifungal activity against contaminants of cell cultures and a wider range between minimal inhibitory to cytotoxic concentration with aspergillus fumigatus, candida albicans and penicillium sp., activity against gram-positive bacteria and lower price. econazole exert ...	1979	521035
aspergillus sinusitis.	since 1969, 79 cases of fungal maxillary sinusitis have been diagnosed. forty-nine were due to aspergillus fumigatus. there were no underlying diseases which depressed cellular immunity and no patient was receiving immunosuppressive drugs or corticosteroids. most patients had received antibacterial therapy before the appearance of fms. treatment was by surgery, nystatin and econazole.	1979	523351