Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
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| comparison of periodontal pathogens between cats and their owners. | the periodontal pathogens porphyromonas gingivalis and tannerella forsythia are strongly associated with periodontal disease and are highly prevalent in humans with periodontitis. porphyromonas and tannerella spp. have also been isolated from the oral cavity of cats. the oral microflora in animals was compared with those in humans in earlier studies, but no studies are available on the comparison of the oral microflora from pets and their respective owners. the aim of this study was to determine ... | 2010 | 20189734 |
| a novel sialic acid utilization and uptake system in the periodontal pathogen tannerella forsythia. | tannerella forsythia is a key contributor to periodontitis, but little is known of its virulence mechanisms. in this study we have investigated the role of sialic acid in biofilm growth of this periodontal pathogen. our data show that biofilm growth of t. forsythia is stimulated by sialic acid, glycolyl sialic acid, and sialyllactose, all three of which are common sugar moieties on a range of important host glycoproteins. we have also established that growth on sialyllactose is dependent on the ... | 2010 | 20190043 |
| the microbiota associated with implants restored with platform switching: a preliminary report. | it was demonstrated that implants restored according to a platform-switching concept presented less crestal bone loss than implants restored with standard protocols. the aim of this study is to examine differences between the composition of the peri-implant microbiotas associated with implants restored with the platform-switching approach and implants restored with a standard internal connection protocol. | 2010 | 20192867 |
| oral biofilm architecture on natural teeth. | periodontitis and caries are infectious diseases of the oral cavity in which oral biofilms play a causative role. moreover, oral biofilms are widely studied as model systems for bacterial adhesion, biofilm development, and biofilm resistance to antibiotics, due to their widespread presence and accessibility. despite descriptions of initial plaque formation on the tooth surface, studies on mature plaque and plaque structure below the gum are limited to landmark studies from the 1970s, without app ... | 2010 | 20195365 |
| efficacy of amoxicillin and metronidazole combination for the management of generalized aggressive periodontitis. | the aim of this study is to evaluate the effects of metronidazole-amoxicillin combination on clinical and microbiologic parameters in patients with generalized aggressive periodontitis. | 2010 | 20214441 |
| detection of periodontopathogenic bacteria in pregnant women by traditional anaerobic culture method and by a commercial molecular genetic method. | to culture facultative and strict anaerobic bacteria is a well-established method for analyzing subgingival plaque samples. micro-ident and micro-ident plus (hain lifescience gmbh, nehren, germany) tests are two commercially available rapid pcr-based methods for the identification and quantification of putative periodontopathogen bacteria. in this study, we compared these commercial pcr-based hybridization methods with conventional anaerobic culture technique. a total of 36 subgingival plaque sa ... | 2010 | 20219690 |
| short-term effects of systemic antibiotics during periodontal healing. | to investigate the short-term effects of nonsurgical therapy (scaling and root planing, srp) on the subgingival microbiota in chronic (cp) and aggressive (ap) periodontal disease. | 2010 | 20305865 |
| synergistic effects of lipopolysaccharides from periodontopathic bacteria on pro-inflammatory cytokine production in an ex vivo whole blood model. | porphyromonas gingivalis, treponema denticola, and tannerella forsythia have been strongly associated with chronic periodontitis. this disease is characterized by an accumulation of inflammatory cells in periodontal tissue and subgingival sites. the secretion of high levels of inflammatory cytokines by those cells is believed to contribute to periodontal tissue destruction. the aim of this study was to investigate the inflammatory response of whole blood from periodontitis patients following cha ... | 2010 | 20331798 |
| dna from porphyromonas gingivalis and tannerella forsythia induce cytokine production in human monocytic cell lines. | toll-like receptor 9 (tlr9) expression is increased in periodontally diseased tissues compared with healthy sites indicating a possible role of tlr9 and its ligand, bacterial dna (bdna), in periodontal disease pathology. here, we determine the immunostimulatory effects of periodontal bdna in human monocytic cells (thp-1). thp-1 cells were stimulated with dna of two putative periodontal pathogens: porphyromonas gingivalis and tannerella forsythia. the role of tlr9 in periodontal bdna-initiated cy ... | 2010 | 20331800 |
| do elderly edentulous patients with a history of periodontitis harbor periodontal pathogens? | the presence of periodontal pathogens in the oral cavity may impact implant survival. therefore, this study aimed to determine the prevalence of campylobacter rectus, porphyromonas gingivalis, aggregatibacter actinomycetemcomitans, prevotella intermedia, tannerella forsythia, treponema denticola, eikenella corrodens and parvimonas micra in a specific elderly population with a history of periodontitis who have never worn dentures. | 2010 | 20337663 |
| profiling of subgingival plaque biofilm microflora from periodontally healthy subjects and from subjects with periodontitis using quantitative real-time pcr. | qualitative and quantitative changes of the subgingival plaque biofilm microflora in periodontal pockets are thought to be associated with the development and progression of periodontitis. the aims of the present study were to quantify the proportions of nine periodontitis-associated bacterial species and four streptococcus species in subgingival plaque, and to evaluate their relationship with periodontitis quantitatively. | 2010 | 20337892 |
| clinical periodontal and microbiologic parameters in patients with crohn's disease with consideration of the card15 genotype. | crohn's disease (cd) was reported to have oral manifestations. however, data on periodontal parameters and oral microbiology in cd are rare. recent studies showed associations of variants in the caspase recruitment domain (card)15 gene with cd that are involved in the immune response toward bacterial products. our aim is to investigate the periodontal status and prevalence of periodontal pathogens in patients with cd under consideration of the card15 polymorphism. | 2010 | 20373538 |
| proteolytic inactivation of ll-37 by karilysin, a novel virulence mechanism of tannerella forsythia. | tannerella forsythia is a gram-negative bacterium strongly associated with the development and/or progression of periodontal disease. here, we have shown that a newly characterized matrix metalloprotease-like enzyme, referred to as karilysin, efficiently cleaved the antimicrobial peptide ll-37, significantly reducing its bactericidal activity. this may contribute to the resistance of t. forsythia to the antibacterial activity of ll-37, since their vitality was found not to be affected by ll-37 a ... | 2010 | 20375548 |
| oral microbiota of children in a school-based dental clinic. | dental caries disproportionately affects disadvantaged subjects. this study hypothesized that there were greater caries extent and higher levels of caries-associated and anaerobic subgingival bacterial species in oral samples of hispanic and immigrant children compared with non-hispanic and us born children. | 2010 | 19879369 |
| rapid quantification of periodontitis-related bacteria using a novel modification of invader plus technologies. | the invader plus technology is a sensitive, rapid method for the detection and quantification of nucleic acid. while the original technology is based on the amplification by polymerase chain reaction (pcr) of the target sequence followed by its detection using the invader technology, the current modification allows simultaneous pcr amplification and invader reaction. the pcr primers and the invader probes are designed to operate at the same temperature. this allows simpler design and faster resu ... | 2010 | 18718748 |
| bovine milk fermented with lactobacillus rhamnosus l8020 decreases the oral carriage of mutans streptococci and the burden of periodontal pathogens. | the aim of this study was to find the oral isolate of lactobacilli, which has the potential to inhibit either periodontal, cariogenic, or fungal pathogens in vitro, and to examine the effects of bovine milk fermented with the isolate on the oral carriage of cariogenic and periodontal pathogens. | 2011 | 25426790 |
| decreased phosphorylation of platelet vasodilator-stimulated phosphoprotein in periodontitis--a role of periodontal pathogens. | epidemiological studies indicate an association between periodontitis and cardiovascular disease, but the underlying mechanisms are poorly understood. vasodilator-stimulated phosphoprotein (vasp) in its phosphorylated form represents a regulator of platelet function and an indicator for the sensitivity of platelets towards physiologically relevant antagonists of platelet function. as platelets and their activation state play a central role in the development of cardiovascular disease, this study ... | 2011 | 21435699 |
| detection of periodontal bacteria in atheromatous plaques by nested polymerase chain reaction. | background. in recent years, increasing evidence regarding the potential association between periodontal diseases and cardiovascular diseases has been elicited. the available evidence underlines the importance of detecting periodontal pathogens on atheromatous plaques as the first step in demonstrating the causal relationship between both entities. it is the main aim of this investigation to detect periodontitis-associated bacteria from carotid artery atheromatous plaques recovered from patients ... | 2011 | 21453047 |
| oral health behaviors, periodontal disease and pathogens in preeclampsia: a case-control study in korea. | background: the aim of this study was to confirm the association among oral health behaviors, periodontitis and preeclampsia in korean women. methods: this study was designed as a case-control study. sixteen preeclamptic and forty eight non-preeclamptic women after delivery were included in this study from november 2007 to january 2010. information on demographics, health behaviors, obstetric and systemic disease that may influence periodontal condition and preeclampsia was collected. full mouth ... | 2011 | 21486182 |
| microbial changes after full-mouth tooth extraction, followed by 2-stage implant placement. | quirynen m, van assche n. microbial changes after full-mouth tooth extraction, followed by 2-stage implant placement. j clin peridontol 2011; doi: 10.1111/j.1600-051x.2011.01728.x. abstract: background: recent studies showed that qpcr could detect bacteria related to periodontitis and peri-implantitis in a low concentration after full-mouth tooth extraction. this study monitored the microbiota from tooth extraction, over 9 months of full edentulism, up to 1 year after abutment connection. materi ... | 2011 | 21488934 |
| a novel approach in the use of subgingival controlled-release delivery of chlorhexidine in chronic periodontitis: a randomized clinical trial. | background: we aimed to analyze clinical, microbiological, and serological effects of chlorhexidine (chx) chips used as subgingival controlled-release-delivery-device before and immediately after scaling and root-planing (srp). methods: 24 patients presenting with at least 12 teeth with ppd ≥5 mm and bop were assigned in test or control groups. after prophylaxis, chx chips (test) or placebo chips (control) were placed in pockets with ppd ≥5mm. ten days later srp was performed in all teeth with p ... | 2011 | 21491990 |
| viral-bacterial associations in acute apical abscesses. | objective: viral-bacterial and bacterial synergism have been suggested to contribute to the pathogenesis of several human diseases. this study sought to investigate the possible associations between 9 candidate endodontic bacterial pathogens and 9 human viruses in samples from acute apical abscesses. study design: dna extracts from purulent exudate aspirates of 33 cases of acute apical abscess were surveyed for the presence of 9 selected bacterial species using a 16s ribosomal rna gene-based nes ... | 2011 | 21507684 |
| detection and clonal analysis of anaerobic bacteria associated to endodontic-periodontal lesions. | background: microbial agents in the root canal systems can induce periodontal inflammation. the aims of this study were to detect anaerobic microorganims in endodontic-periodontal lesions, determine the genetic diversity among them and assess the simultaneous colonization of the pulp and periodontal microenvironments by a single clone. methods: twenty-seven teeth of patients with endodontic-periodontal lesions were selected. samples were spread on an agar-blood medium, the detection of each spec ... | 2011 | 21513472 |
| inhibition of host- and bacteria-derived proteinases by natural anthocyanins. | santos j, la vd, bergeron c, grenier d. inhibition of host- and bacteria-derived proteinases by natural anthocyanins. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01372.x. © 2011 john wiley & sons a/s background and objectives: host- and bacteria-derived proteinases are considered to play critical roles in periodontitis progression. this study investigated the ability of a blackcurrant extract and its major anthocyanins (cyanidin-3-o-glucoside, cyanidin-3-o-rutinoside and delphinidin-3-o ... | 2011 | 21517858 |
| prevalence of periodontopathogens in a black brazilian secluded community matched with a black urban population. | to evaluate the prevalence of periodontopathogens according to periodontal profile in a black brazilian secluded community matched with an urban black population. | 2011 | 22320070 |
| reduction of two red complex bacteria by sustained-release doxycycline and correlation to improvement in mean pocket depth. | the objective was to evaluate the effects of an 8.5% sustained-release doxycycline-containing polymer formulation (srdf) on deep pockets (pocket depth [pd] ≥ 7 mm) in chronic periodontitis. total bacterial counts were used to estimate the number of viable bacteria present before treatment and for up to 6 months posttreatment. | 2011 | 23738858 |
| relationship between the pathogenic representatives of periodontal pockets microbiocenosis in patients with periodontitis with varying degrees of severity. | periodontitis is a common disease that is considered to be a manifestation of the distortion of the ratio between the normal and conditionally pathogenic microflora of periodontal pockets. in this study, the ratio between the six most important periodontal pathogens and the total microflora of the periodontal pocket in healthy individuals and patients with varying severity of periodontitis was ascertained by quantitative real-time pcr. it was ascertained that the relative content ofporphyromonas ... | 2011 | 22649688 |
| salivary infectious agents and periodontal disease status. | the potential of salivary microorganisms to diagnose periodontal disease and to guide periodontal treatment is a research topic of current interest. this study aimed to determine whether the salivary counts of periodontopathic microbes correlated with the periodontal pocket counts of the same infectious agents, and whether the salivary counts of the test infectious agents could distinguish among individuals with periodontal health and various types of periodontal disease. | 2011 | 21261620 |
| polymicrobial infection with periodontal pathogens specifically enhances microrna mir-146a in apoe-/- mice during experimental periodontal disease. | porphyromonas gingivalis, treponema denticola, and tannerella forsythia are periodontal pathogens associated with the etiology of adult periodontitis as polymicrobial infections. recent studies demonstrated that oral infection with p. gingivalis induces both periodontal disease and atherosclerosis in hyperlipidemic and proatherogenic apoe(-/-) mice. in this study, we explored the expression of micrornas (mirnas) in maxillas (periodontium) and spleens isolated from apoe(-/-) mice infected with p. ... | 2011 | 21263019 |
| stimulants of toll-like receptors 2 and 4 are elevated in saliva of periodontitis patients compared with healthy subjects. | because the absorption of stimulants of toll-like receptor (tlr)2 and tlr4 from the gastrointestinal tract into the circulation has been proposed to promote the development of atherosclerosis and insulin resistance, we aimed to quantify the abundance of stimulants of tlr2 and tlr4 in human saliva. | 2011 | 21284689 |
| effect of teenage smoking on the prevalence of periodontal bacteria. | the aim of our study was to investigate how teenage smoking affects the prevalence of periodontal bacteria and periodontal health with the hypothesis that smoking increases the prevalence of the bacteria. oral health of 264 adolescents (15- to 16-year-olds) was clinically examined, and their smoking history was recorded. the participants also filled in a structured questionnaire recording their general health and health habits. pooled subgingival plaque samples were taken for polymerase chain re ... | 2011 | 21340603 |
| association between periodontal pathogens and risk of nonfatal myocardial infarction. | the direct effect of periodontal pathogens on atherosclerotic plaque development has been suggested as a potential mechanism for the observed association between periodontal disease and coronary heart disease, but few studies have tested this theory. | 2011 | 21375559 |
| a hybrid two-component system of tannerella forsythia affects autoaggregation and post-translational modification of surface proteins. | tannerella forsythia is a gram-negative oral anaerobe closely associated with both periodontal and periapical diseases. the orf tf0022 of strain atcc 43037 encodes a hybrid two-component system consisting of an n-terminal histidine kinase and a c-terminal response regulator. disruption of the tf0022 locus enhanced autoaggregation of the broth-cultured cells. comparative proteome analyses revealed that two s-layer proteins in the tf0022 mutant exhibited decreased apparent masses by denaturing gel ... | 2011 | 21385202 |
| detection of specific periodontal microorganisms from bacteraemia samples after periodontal therapy using molecular-based diagnostics. | the aim of this study was to assess the presence of subgingival pathogens in peripheral blood samples from periodontitis patients before and after scaling and root planing (sc/rp) using nested polymerase chain reaction (nested pcr). | 2011 | 21392048 |
| association of red complex, a. actinomycetemcomitans and non-oral bacteria with periodontal diseases. | pathogens related to systemic infections have been detected in the periodontal microbiota. the relationship amongst these pathogens, periodontal bacteria and periodontal clinical status is poorly understood. this study evaluated the association amongst red complex, a. actinomycetemcomitans (a.a) and non-oral pathogenic bacteria in subjects with good periodontal health (ph), gingivitis (g), chronic (cp) and aggressive (ap) periodontitis. | 2011 | 21397893 |
| clinical periodontal and microbiologic parameters in patients with rheumatoid arthritis. | background: a limited number of studies suggest the prevalence of periodontal pathogens in patients with rheumatoid arthritis (ra); however, results are inconsistent. the aim of this study was to investigate clinical periodontal and microbiologic parameters in patients with ra. methods: 66 patients with ra aged 49.5±8.4 years participated in the study. the periodontal situation was assessed with the periodontal screening index (psr(®)/psi); allocated to: healthy, gingivitis (psr(®)/psi score 0-2 ... | 2011 | 21405936 |
| clustering of subgingival microbial species in adolescents with periodontitis. | it has become increasingly recognized that groups of microorganisms interact within the subgingival plaque of adult subjects with periodontitis. it is much less clear, however, whether the consortia of microorganisms associated with periodontitis are different in early and more advanced cases of periodontitis. to investigate this point further, subgingival plaque was collected from six sites in 87 adolescents with periodontitis and 73 controls and the samples were analyzed for the detection of 1 ... | 2011 | 21410554 |
| [prevalence of tannerella forsythensis in subgingival plaque of type 2 diabetic patients]. | to study the prevalence of tannerella forsythensis (t. forsythensis) in the subgingival plaque of type 2 diabetes, analyze the relationship between tforsythensis and related factors, discuss the role of t. forsythensis in the chronic periodontitis and type 2 diabetes. | 2011 | 21427902 |
| effect of smoking on subgingival microflora of patients with periodontitis in japan. | smoking is a risk factor for periodontitis. to clarify the contribution of smoking to periodontitis, it is essential to assess the relationship between smoking and the subgingival microflora. the aim of this study was to gain an insight into the influence of smoking on the microflora of japanese patients with periodontitis. | 2011 | 21208407 |
| identification of periodontal pathogens and severity of periodontitis in patients with and without chronic kidney disease. | in this study of patients with chronic periodontitis (cp), the severity of the disease and the main periodontal pathogens identified in patients with chronic kidney disease (ckd) were compared with those detected in individuals without systemic disease. | 2011 | 21211789 |
| comparison of real-time polymerase chain reaction and dna-strip technology in microbiological evaluation of periodontitis treatment. | the impact of a semiquantitative commercially available test based on dna-strip technology (microident®, hain lifescience, nehren, germany) on diagnosis and treatment of severe chronic periodontitis of 25 periodontitis patients was evaluated in comparison with a quantitative in-house real-time pcr. subgingival plaque samples were collected at baseline as well as at 3, 6, and 12 months later. after extracting dna, aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, tannerella forsyth ... | 2011 | 21146709 |
| a 6-month study of the effects of 0.3% triclosan/copolymer dentifrice on dental implants. | supportive therapy to maintain dental implants is increasingly important. this study examined the effect of a 0.3% triclosan/2% copolymer dentifrice on oral biofilms and gingival inflammation (gi) on dental implants and peri-implant tissues. | 2011 | 20831669 |
| spiramycin resistance in human periodontitis microbiota. | purpose: the occurrence of in vitro resistance to therapeutic concentrations of spiramycin, amoxicillin, and metronidazole was determined for putative periodontal pathogens isolated in the united states. materials and methods: subgingival plaque specimens from 37 consecutive adults with untreated severe periodontitis were anaerobically cultured, and isolated putative periodontal pathogens were identified to a species level. in vitro resistance to spiramycin at 4 μg/ml, amoxicillin at 8 μg/ml, an ... | 2011 | 21524712 |
| bacteroides uniformis is a putative bacterial species associated with the degradation of the isoflavone genistein in human feces. | inter-individual variation in isoflavone absorption depends on gut microbial degradation and affects the efficacy of these compounds. we hypothesized that inter-individual variation in fecal isoflavone disappearance coincided with variation in bacterial species. in vitro anaerobic fecal disappearance of isoflavones was measured from 33 participants by hplc. fecal microbial 16s rrna variable region pcr products were obtained from 4 participants with the greatest and least genistein or glycitein d ... | 2011 | 21525249 |
| clarithromycin, as an adjunct to non surgical periodontal therapy for chronic periodontitis: a double blinded, placebo controlled, randomized clinical trial. | objective: along with conventional non-surgical periodontal therapy (nspt) systemic antimicrobials may provide more effective treatment for chronic periodontitis by targeting tissue-invasive bacteria. the aim of this randomized, placebo-controlled, double-masked clinical trial was to evaluate the adjunctive effects of oral clarithromycin (clm) to non-surgical periodontal therapy for chronic periodontitis. methods: 40 patients were categorized into two groups: test group - scaling and root planin ... | 2011 | 21529775 |
| periodontal conditions and prevalence of putative periodontopathogens and candida spp. in insulin-dependent type 2 diabetic and non-diabetic patients with chronic periodontitis-a pilot study. | objectives: the aims of this study were to evaluate periodontal conditions and identify the presence of aggregatibacter actinomycetemcomitans, porphyromonas gingivalis and tannerella forsythia, and four different species of candida (c. albicans, c. dubliniensis, c. glabrata and c. tropicalis) in periodontal pockets and furcation sites of insulin-dependent type 2 diabetic and non-diabetic patients with generalised chronic periodontitis. design: clinical parameters, including oral status assessed ... | 2011 | 21529777 |
| inhibitory effect of lactobacillus reuteri on periodontopathic and cariogenic bacteria. | the interaction between lactobacillus reuteri, a probiotic bacterium, and oral pathogenic bacteria have not been studied adequately. this study examined the effects of l. reuteri on the proliferation of periodontopathic bacteria including aggregatibacter actinomycetemcomitans, fusobacterium nucleatum, porphyromonas gingivalis, and tannerella forsythia, and on the formation of streptococcus mutans biofilms. human-derived l. reuteri strains (kctc 3594 and kctc 3678) and rat-derived l. reuteri kctc ... | 2011 | 21538238 |
| effect of periodontopathogen lipopolysaccharides and proinflammatory cytokines on cd46, cd55, and cd59 gene/protein expression by oral epithelial cells. | membrane-anchored complement regulatory proteins (crps), including cd46, cd55, and cd59, protect host cells from complement attack. in the present study, we investigated whether periodontopathogen lipopolysaccharide and proinflammatory cytokines modulate crp gene/protein expression in human oral epithelial cells. the lipopolysaccharide of treponema denticola and tannerella forsythia were the most potent for increasing the gene expression of cd55 and cd59, and to a lesser extent cd46, after a 48- ... | 2011 | 21545652 |
| relationship between herpes viruses and periodontopathogens in hiv patients with periodontitis. | aim: to verify a possible association between herpes viruses and periodontal pathogens in individuals with human immunodeficiency virus (hiv+) and periodontitis. material and methods: twenty-seven hiv+ subjects with chronic periodontitis (cp) and 23 hiv+ patients with gingivitis (g) were included in the study. probing depth, clinical attachment level, gingival index, and plaque index were recorded. blood, saliva, and subgingival plaque were processed for viral and bacterial identification. bacte ... | 2011 | 21563945 |
| effectiveness of ozone against periodontal pathogenic microorganisms. | huth kc, quirling m, lenzke s, paschos e, kamereck k, brand k, hickel r, ilie n. effectiveness of ozone against periodontal pathogenic microorganisms. eur j oral sci 2011; 119: 204-210. ©2011 eur j oral sci ozone has been proposed as an adjunct antiseptic in periodontitis therapy. the aim of this study was to investigate the antimicrobial effectiveness of gaseous/aqueous ozone, in comparison with that of the established antiseptic chlorhexidine digluconate (chx), against periodontal microorganis ... | 2011 | 21564314 |
| antimicrobial effect of adjunctive use of chlorhexidine mouthrinse in untreated gingivitis: a randomized, placebo-controlled study. | becerik s, türkoğlu o, emingil g, vural c, özdemir g, atilla g. anti-microbial effect of adjunctive use of chlorhexidine mouthrinse in untreated gingivitis: a randomized, placebo-controlled study. apmis 2011; 119: 364-72. the aim of this study was to examine the effectiveness of chlorhexidine mouthrinse (chx) in addition to daily plaque control on subgingival microbiota in patients with untreated gingivitis. fifty gingivitis patients were randomized to chx or placebo groups. chx group rinsed wit ... | 2011 | 21569094 |
| periodontopathogen and epstein-barr virus contamination affects transplanted bone volume in sinus augmentation. | background: bone microbial contamination can impair osteogenesis. human herpesviruses-associated vasculitis can cause vascular damage within the osseous graft and host. this study was conducted to substantiate specific contamination and assess the impact six months after sinus augmentation. methods: culture and polymerase chain reaction (pcr)-based identification were done on harvested bone particles and unstimulated whole saliva in a group of 30 patients undergoing maxillary sinus augmentation. ... | 2011 | 21574831 |
| levels of serum igg specific to the bspa protein of tannerella forsythia are related to the periodontal status. | background: tannerella forsythia is a gram-negative anaerobe implicated in the development of periodontal disease (pd). bspa is a surface expressed and secreted protein, recognized as an important virulence factor of t. forsythia. this study was undertaken to determine if t. forsythia bacterial surface protein a (bspa) induces an antibody response in pd. we hypothesized that serum immunoglobulin g (igg) antibody levels against bspa will correlate with patient's disease. methods: sera were obtain ... | 2011 | 21609257 |
| identification of periodontal pathogens in healthy periimplant sites. | : the aim of this study was to evaluate the presence of periodontopathogens in subgingival periimplant sites in partially edentulous patients using polymerase chain reaction procedures, with regard to areas with clinical and radiographic signs of health and areas presenting periimplant disease. | 2011 | 21613949 |
| tannerella forsythia invasion in oral epithelial cells requires phosphoinositide-3-kinase activation and clathrin-mediated endocytosis. | tannerella forsythia, a gram-negative anaerobe implicated periodontitis, has been detected within human buccal epithelial cells and shown to invade oral epithelial cells in vitro. we have previously shown that this bacterium triggers host tyrosine kinase-dependent phosphorylation and actin-dependent cytoskeleton re-organization for invasion. on the bacterial side, the leucine-rich repeat surface bspa protein is important for entry. this present study was undertaken to identify host signaling mol ... | 2011 | 21622527 |
| tlr2 signaling and th2 responses drive tannerella forsythia-induced periodontal bone loss. | periodontal disease (pd) is a chronic inflammation of the tooth-supporting soft tissue and alveolar bone due to infection by a select group of gram-negative microbes, which leads to tooth loss if untreated. because mice deficient in cd4(+) cells are resistant to infection-induced alveolar bone loss, th cells have been implicated in bone-destructive processes during pd. however, the extent to which different th cell subtypes play roles in pathogenesis or host protection remains to be defined and ... | 2011 | 21632710 |
| prevotella nigrescens and porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. | yakob m, söder b, meurman jh, jogestrand t, nowak j, söder p.-ö. prevotella nigrescens and porphyromonas gingivalis are associated with signs of carotid atherosclerosis in subjects with and without periodontitis. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01398.x. © 2011 john wiley & sons a/s background and objective: oral microorganisms may be involved in the development of cardiovascular diseases, and porphyromonas gingivalis is one of the periodontal microorganisms that has been fou ... | 2011 | 21793826 |
| evaluation of local drug-delivery system containing 2% whole turmeric gel used as an adjunct to scaling and root planing in chronic periodontitis: a clinical and microbiological study. | to compare the effect of experimental local-drug delivery system containing 2% whole turmeric (gel form) as an adjunct to scaling and root planing (srp) with the effect achieved using srp alone by assessing their respective effects on plaque, gingival inflammation, bleeding on probing pocket depth, relative attachment levels and trypsin-like enzyme activity of "red complex" microorganisms, namely, bacteroides forsythus, porphvromonas gingivalis and treponema denticola. | 2011 | 21772719 |
| detection of periodontal markers in chronic periodontitis. | the aim was to compare the detection frequency of periodontopathogens by using the pado test 4.5 and checkerboard dna-dna hybridization technique in chronic periodontitis patients.thirty patients with chronic periodontitis were tested cross-sectionally with dna/rna oligogenomic probe method (iai pado test 4.5) and dna/dna whole genomic probe (checkerboard) method. samples were taken by two paper points at the deepest site in each of the four quadrants and pooled into one sample for each of the t ... | 2011 | 21769304 |
| clinical and microbiological results 12 months after scaling and root planing with different irrigation solutions in patients with moderate chronic periodontitis ?a pilot randomized trial. | aim: the aim of this study was to determine in a randomized trial the impact on treatment outcome after 12 months of different subgingival irrigation solutions during scaling and root planing (srp). materials and methods: 51 adult volunteers with generalized chronic periodontitis were treated by full mouth srp using 0.9 % sodium chloride, 0.12 % chlorhexidine digluconate or 7.5 % povidone-iodine for subgingival irrigation during srp. prior to srp, after three and twelve months probing depth (pd) ... | 2011 | 21749169 |
| microbiologic changes in subgingival plaque before and during the early period of orthodontic treatment. | abstract objective: to evaluate changes in subgingival microbiota before and during the leveling and alignment orthodontic stage using the polymerase chain reaction (pcr) method. materials and methods: thirty orthodontic patients (17 females and 13 males; aged 16.7 -¦ 6.5-áy) were included in this study. subgingival microbial samples were taken from the disto-buccal gingival crevice of the left upper central incisors, the left lower central incisors, the mesio-buccal gingival crevice of the left ... | 2011 | 21827233 |
| [prevalence of helicobacter pylori detected by real-time pcr in the subgingival plaque of patients with chronic periodontitis]. | helicobacter pylori plays a significant role in gastric disease. the aim of the present pilot study was to evaluate the prevalence of h. pylori detected by real-time polymerase chain reaction (real-time pcr) in the sub-gingival plaque of chronic periodontitis patients and to determine periodontopathogens profile of positive sites at h. pylori. | 2011 | 21688602 |
| clinical, microbiologic, and immunologic factors of orthodontic treatment-induced gingival enlargement. | the aim of this study was to investigate the microbiologic and immunologic factors related to orthodontic treatment-induced gingival enlargement (ge). | 2011 | 21724088 |
| exploring bacterial diversity of endodontic microbiota by cloning and sequencing 16s rrna. | the characterization of microbial communities infecting the endodontic system in each clinical condition may help on the establishment of a correct prognosis and distinct strategies of treatment. the purpose of this study was to determine the bacterial diversity in primary endodontic infections by 16s ribosomal-rna (rrna) sequence analysis. | 2011 | 21689545 |
| the genetic impact of the q551r interleukin-4 receptor alpha polymorphism for aggressive or chronic periodontitis and the occurrence of periodontopathic bacteria. | objective: the q551r polymorphism of the gene encoded for the +¦ chain of the interleukin-4 receptor (il-4ra) could influence both il-4 and il-13 signalling. since both cytokines could be important in the pathogenesis of periodontitis the aim of this study was to evaluate putative associations of the q551r polymorphism to generalized aggressive or chronic periodontitis and five periodontopathogens. design: 154 patients with severe generalized periodontitis (chronic: n=68, mean age=48.7-¦9.4 year ... | 2011 | 21733492 |
| polymicrobial periodontal pathogen transcriptomes in calvarial bone and soft tissue. | porphyromonas gingivalis, treponema denticola, and tannerella forsythia are consistently associated with adult periodontitis. this study sought to document the host transcriptome to a p. gingivalis, t. denticola, and t.forsythia challenge as a polymicrobial infection using a murine calvarial model of acute inflammation and bone resorption. mice were infected with p. gingivalis, t. denticola, and t. forsythia over the calvaria, after which the soft tissues and calvarial bones were excised. a muri ... | 2011 | 21896157 |
| [Role of several periodontopathogenic microorganisms and tlr4 gene Asp299Gly polymorphism in atherosclerosis pathogenesis]. | Establishment of presence of periodonto-pathogenic microorganisms in atherosclerosis plaque and surrounding tissues, and possible relation of development of atherosclerosis and TLR4 gene Asp299Gly polymorphism in ischemic heart disease patients (IHD). | 2011 | 22145357 |
| evidence for graft colonization with periodontal pathogens in lung transplant recipients. | summary bronchiolitis obliterans syndrome (bos) is a major cause of late graft dysfunction in lung transplant recipients. there is increasing evidence that beside alloimmunologic injury also non-alloimmunologic inflammatory conditions may raise the risk of acute and chronic rejection. the oral cavity represents a possible reservoir for pathogenic bacteria due to its close anatomical proximity. in this pilot study, the presence of pathogenic periodontal bacteria in the oral cavity as well as in t ... | 2011 | 22203528 |
| Levels of periodontal pathogens in neonatal gastric aspirates and possible maternal sites of origin. | Maternal periodontal infection has been recognized as a risk factor for preterm and low birthweight infants. It is suspected that pathogens causing periodontal disease may translocate to the amniotic cavity and so contribute to triggering an adverse pregnancy outcome. This study aimed to determine levels and proportions of periodontal bacteria in neonatal gastric aspirates obtained from complicated pregnancies and the respective maternal oral and vaginal samples using a quantitative polymerase c ... | 2011 | 21896155 |
| detection of periodontal pathogens in newborns and children with mixed dentition. | we report the age-related prevalence of red complex periodontal pathogens, porphyromonas gingivalis, treponema denticola, and tannerella forsythia, along with four strains of orange complex pathogens. the bacteria present in samples isolated from tongue, cheek, and subgingival sulcus in edentulous newborns and children with mixed dentition were monitored by polymerase chain reaction (pcr). p. gingivalis was not detected in any site of any subject in the two groups tested. however, t. denticola w ... | 2011 | 21928086 |
| extracellular deoxyribonuclease production by periodontal bacteria. | palmer lj, chapple ilc, wright hj, roberts a, cooper pr. extracellular deoxyribonuclease production by periodontal bacteria. j periodont res 2011; doi: 10.1111/j.1600-0765.2011.01451.x © 2011 john wiley & sons a/s background and objective: whilst certain bacteria have long been known to secrete extracellular deoxyribonuclease (dnase), the purpose in microbial physiology was unclear. recently, however, this enzyme has been demonstrated to confer enhanced virulence, enabling bacteria to evade the ... | 2011 | 22150619 |
| the subgingival microbiota of papillon-lefèvre syndrome. | background: there is little information about the microbiological profiles of periodontal lesions in papillon-lefèvre syndrome (pls) and the significance of bacteria in the pathogenesis of periodontitis in these patients. this comprehensive analysis of the subgingival microbiota in pls patients used 16s rrna clonal analysis and the 16s rrna-based human oral microbe identification microarray (homim). methods: thirteen pls patients, from 7 unrelated families, volunteered for this microbiological s ... | 2011 | 22141356 |
| effect of a self-etching adhesive containing an antibacterial monomer on clinical periodontal parameters and subgingival microbiologic composition in orthodontic patients. | the aims of this study were to evaluate the effect of a self-etching adhesive system containing an antibacterial monomer on periodontal health and subgingival microbiologic composition in orthodontic patients and to compare it with a conventional adhesive system. | 2011 | 21967952 |
| salivary levels of antibacterial peptide (ll-37/hcap-18) and cotinine in periodontitis patients. | background: the purpose of this study was to examine the relationship between salivary ll-37 levels and clinical severity in chronic periodontitis (cp) patients. the presence/absence of four periodontopathic bacteria and salivary cotinine levels were also examined in order to assess the impact of these factors on ll-37 production. methods: unstimulated salivary samples were collected from 69 cp patients. salivary concentrations of ll-37 and cotinine were measured by enzyme-linked immunosorbent ... | 2011 | 21942788 |
| evaluation of the subgingival microbiota of alcoholic and non-alcoholic individuals. | the aim of this study was to evaluate the composition of the subgingival microbiota of alcoholic and non-alcoholic individuals. | 2011 | 21864643 |
| characterization and scope of s-layer protein o-glycosylation in tannerella forsythia. | cell surface glycosylation is an important element in defining the life of pathogenic bacteria. tannerella forsythia is a gram-negative, anaerobic periodontal pathogen inhabiting the subgingival plaque biofilms. it is completely covered by a two-dimensional crystalline surface layer (s-layer) composed of two glycoproteins. although the s-layer has previously been shown to delay the bacterium's recognition by the innate immune system, we characterize here the s-layer protein o-glycosylation as a ... | 2011 | 21911490 |
| role of sialidase in glycoprotein utilization by tannerella forsythia. | the major bacterial pathogens associated with periodontitis include tannerella forsythia. we previously discovered that sialic acid stimulates biofilm growth of t. forsythia, and that sialidase activity is key to utilization of sialoconjugate sugars and is involved in host-pathogen interactions in vitro. the aim of this work was to assess the influence of the nanh sialidase on initial biofilm adhesion and growth in experiments where the only source of sialic acid was sialoglycoproteins or human ... | 2011 | 21885482 |
| Trefoil Factors in Saliva and Gingival Tissues of Patients With Chronic Periodontitis. | Background: Trefoil factors (TFFs) are secreted molecules which are involved in cytoprotection against tissue damage, and the immune response. TFFs have been detected in saliva and oral tissues, but their clinical significance has never been investigated in patients with chronic periodontitis. The objective of our study was to determine if TFF expression in saliva and gingival tissues was associated with periodontal pathology. Methods: Saliva and gingival tissue samples were collected from 25 n ... | 2011 | 22181686 |
| the effect of spiramycin on porphyromonas gingivalis and other "classic" periopathogens. | in clinical trials, spiramycin has shown additional benefit overscaling and root planing on pocket depth reduction, but its effect on periodontal microbiota was evaluated only by darkfield microscopy. therefore, this study was conducted to determine the effect of spiramycin administration on porphyromonas gingivalis and other periodontopathic bacteria using 16s rarn pcr technique. thirty two non-smoker adults with untreated periodontitis and pocket depth > or = 7 mm. were evaluated to participat ... | 2011 | 22010417 |
| clinical and microbiological evaluation, by real-time pcr, of non-surgical treatment of aggressive periodontitis associated with amoxicillin and metronidazole. | background: to evaluate the clinical and microbiological changes resulting from non-surgical periodontal treatment associated with amoxicillin and metronidazole, in individuals with aggressive periodontitis (agp). methods: 15 subjects with agp received non-surgical periodontal treatment and 45 days after completion of treatment, were treated with antibiotics. clinical data and samples of subgingival plaque were collected at baseline, 45 days after the non-surgical periodontal treatment and 1 mon ... | 2011 | 22060046 |
| symptomatic and asymptomatic apical periodontitis associated with red complex bacteria: clinical and microbiological evaluation. | in this study, the association of red complex (rc) bacteria that include treponema denticola, tannerella forsythia and porphyromonas gingivalis with acute, exacerbated or chronic apical periodontitis was evaluated. seventy-one patients with periapical disease were evaluated by clinical examination and microbiological samples obtained from the root canals were analyzed by a polymerase chain reaction assay. twenty-one (29.6%) samples were positive for rc bacteria, with t. ... | 2011 | 22143381 |
| subgingival microbial consortia and the clinical features of periodontitis in adolescents. | this study aimed to investigate the association between microbial consortia and the clinical features of periodontitis using a multilevel modeling approach. a total of 958 sites in 87 adolescents with periodontitis (cases) and 73 controls were microbiologically sampled and clinically examined. associations between each of the clinical parameters clinical attachment, probing depth, supragingival plaque, calculus, bleeding on probing, and each of 18 bacterial species; and between the same clinical ... | 2011 | 22112031 |
| Associations of periodontal microorganisms with salivary proteins and MMP-8 in gingival crevicular fluid. | OBJECTIVE: We investigated in subjects with and without periodontitis, the levels of certain salivary proteins and matrix metalloproteinase-8 (MMP-8) in gingival crevicular fluid (GCF), in relation to the presence of specific periodontal pathogens. METHODS: Clinical parameters were recorded at baseline, in 1985 and in 2009 from 99 subjects; 56 with and 43 without periodontitis (mean age 59.2 ± SD 2.9). Saliva samples collected in 2009 were analysed for salivary albumin, total protein and immunog ... | 2011 | 22103335 |
| microbiologic findings 1 year after partial- and full-mouth scaling in the treatment of moderate chronic periodontitis. | to investigate the impact on microbiologic variables of full-mouth scaling (fms) and conventional scaling and root planing (csrp) after 12 months. | 2011 | 21909493 |
| Treatment of residual pockets with photodynamic therapy, diode laser, or deep scaling. A randomized, split-mouth controlled clinical trial. | The objective of this work was to compare the effects of antimicrobial photodynamic therapy (PDT), diode soft laser therapy (DSL), and thorough deep scaling and root planing (SRP) for treatment of residual pockets. Thirty-two subjects with a history of non-surgical treatment for chronic periodontitis were included. Residual pockets >4 mm and bleeding upon probing were debrided with an ultrasonic device and then subjected to either PDT, DSL, or SRP. Pocket probing depth (PPD), bleeding on probing ... | 2011 | 22105837 |
| The comparative evaluation of xanthan gel with chlorhexidine (Chlosite) in smokers and non-smokers: A clinical and microbiological assessment. | Prevention of the periodontal disease progression is the primary goal of periodontal therapy. When conventional therapy is found inadequate to attain periodontal health in chronic periodontitis, local antimicrobial agents have been used as an adjunct with scaling and root planning (SRP) which has reproduced encouraging results. Hence, this study was undertaken to evaluate the new sustained released local drug Chlosite clinically and microbiologically in smokers and non-smokers. | 2011 | 22028508 |
| colonisation of the oral cavity by periodontopathic bacteria in complete denture wearers. | gerodontology 2011; doi: 10.1111/j.1741-2358.2011.00506.x colonisation of the oral cavity by periodontopathic bacteria in complete denture wearers objective: the purpose of this study was to investigate colonisation by periodontopathic bacteria and the sites of colonisation in elderly upper and lower complete denture wearers. we also investigated the relationship between level of oral hygiene and colonisation by periodontopathic bacteria. materials and methods: forty edentulous and 37 dentate ... | 2011 | 21929616 |
| ompa-like protein influences cell shape and adhesive activity of tannerella forsythia. | tannerella forsythia, a gram-negative fusiform rod, is implicated in several types of oral anaerobic infections. most gram-negative bacteria have ompa-like proteins that are homologous to the ompa protein in escherichia coli. we identified an ompa-like protein in t. forsythia encoded by the tf1331 gene as one of the major proteins by mass spectrometric analysis. two-dimensional, diagonal electrophoresis showed that the ompa-like protein formed a dimeric or trimeric structure via intermolecular d ... | 2011 | 22053965 |
| Randomized Controlled Trial Assessing Efficacy and Safety of Glycine Powder Air Polishing in Moderate to Deep Periodontal Pockets. | Background: Supragingivally applied glycine powder air polishing (Supra-GPAP) has been shown to remove biofilms in shallow periodontal pockets. This study assessed efficacy and safety of subgingivally applied glycine powder air polishing (Sub-GPAP) in moderate to deep periodontal pockets. Methods: Subjects with chronic periodontitis and intraoral Porphyromonas gingivalis and Tannerella forsythia having completed initial therapy were randomly assigned to receive Sub-GPAP in periodontal pockets wi ... | 2011 | 21861637 |
| molecular detection of human periodontal pathogens in oral swab specimens from dogs in japan. | periodontal diseases are known to be major diseases in humans, and are also common in dogs. the purpose of the present study was to analyze the distribution of periodontitis-related bacterial species using oral swab specimens collected from 26 pet dogs. the distribution of an animal gingival organism porphyromonas gulae, in addition to 10 human periodontitis-related bacterial species, including porphyromonas gingivalis, treponema denticola, tannerella forsythia, capnocytophaga ochracea, capnocyt ... | 2011 | 21916371 |
| salivary biomarkers for predicting the progression of chronic periodontitis. | objective: predicting the progression of periodontitis would allow for targeted supportive periodontal therapy. the purpose of this study was to determine the usefulness of salivary biomarkers for predicting the progression of periodontitis. design: eighty-five chronic periodontitis patients were enrolled in an 18-month longitudinal study. amongst them, 57 experienced progression of periodontitis, indicated at the end of the 18 months by at least one site with >3mm loss of attachment compared wi ... | 2011 | 22030151 |
| Oral Bacterial DNA Differ in Their Ability to Induce Inflammatory Responses in Human Monocytic Cell Lines. | BACKGROUND: DNA of periodontal pathogens, Porphyromonas gingivalis (Pg-DNA) and Tannerella forsythia, stimulate cytokine production in human monocytic cells (THP-1) through Toll like receptor 9 (TLR-9) and nuclear factor kappa B signaling. Fusobacterium nucleatum is one of the most frequently isolated bacteria in periodontally-diseased tissues and reported to synergize with Porhyromonas gingivalis enhancing the pathogenicity. We investigated inflammatory mediator production in THP-1 cells challe ... | 2011 | 22166166 |
| molecular detection of in-vivo microbial contamination of metallic orthodontic brackets by checkerboard dna-dna hybridization. | knowing the microbiota that colonizes orthodontic appliances is important for planning strategies and implementing specific preventive measures during treatment. the purpose of this clinical trial was to evaluate in vivo the contamination of metallic orthodontic brackets with 40 dna probes for different bacterial species by using the checkerboard dna-dna hybridization (cddh) technique. | 2012 | 22196182 |
| microbial profile of patients with periodontitis compared with healthy subjects. | objective: to define and compare the microbiologic profile of subgingival plaque in german patients with periodontitis (including aggressive and advanced chronic periodontitis) and healthy subjects and to determine significant association between isolates and clinical status. aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, and tannerella forsythia are major periodontal pathogens, though it is recognized that other species may also contribute to the pathogenesis of periodontal di ... | 2012 | 22257880 |
| full-mouth disinfection and systemic antimicrobial therapy in generalized aggressive periodontitis: a randomized, placebo-controlled trial. | aim: the present investigation aimed to analyse clinical and microbiological effects of systemic administration of metronidazole and amoxicillin combined with the one-stage-full-mouth-disinfection protocol (osfmd) in generalized aggressive periodontitis patients (g-agp). materials and methods: thirty-nine systemically healthy patients with g-agp were consecutively included. the test group (n = 19) received amoxicillin-metronidazole combination (500 mg of each, three times a day for 7 days) and t ... | 2012 | 22220822 |
| impact of supragingival therapy on subgingival microbial profile in smokers versus non-smokers with severe chronic periodontitis. | the aim of this study was to assess subgingival microbiological changes in smokers versus non-smokers presenting severe chronic periodontitis after supragingival periodontal therapy (st). | 2012 | 22232720 |
| sialic acid, periodontal pathogens and tannerella forsythia: stick around and enjoy the feast! | periodontal pathogens, like any other human commensal or pathogenic bacterium, must possess both the ability to acquire the necessary growth factors and the means to adhere to surfaces or reside and survive in their environmental niche. recent evidence has suggested that sialic acid containing host molecules may provide both of these requirements in vivo for several periodontal pathogens but most notably for the red complex organism tannerella forsythia. several other periodontal pathogens also ... | 2012 | 22230462 |
| porphyromonas endodontalis in chronic periodontitis: a clinical and microbiological cross-sectional study. | although previous studies have shown the presence of porphyromonas endodontalis in chronic periodontitis associated with periapical lesions, the occurrence of this pathogen in diseased periodontal sites without periapical lesions has been poorly investigated. | 2012 | 22232719 |
| periodontal pathogens affect the level of protease inhibitors in gingival crevicular fluid. | in periodontitis, an effective host-response is primarily related to neutrophils loaded with serine proteases, including elastase (ne) and protease 3 (pr3), the extracellular activity of which is tightly controlled by endogenous inhibitors. in vitro these inhibitors are degraded by gingipains, cysteine proteases produced by porphyromonas gingivalis. the purpose of this study was to determine the level of selected protease inhibitors in gingival crevicular fluid (gcf) in relation to periodontal i ... | 2012 | 22230465 |
| cleavage of igg1 in gingival crevicular fluid is associated with the presence of porphyromonas gingivalis. | immunoglobulin (ig) g1 plays an important role in the adaptive immune response. kgp, a lysine-specific cysteine protease from porphyromonas gingivalis, specifically hydrolyses igg1 heavy chains. the purpose of this study was to examine whether cleavage of igg1 occurs in gingival crevicular fluid (gcf) in vivo, and whether there is any association with the presence of porphyromonas gingivalis and other periodontopathogens. | 2012 | 23116446 |