Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| [immunogenicity and the protective effectiveness of the subunit trivalent influenza vaccine grippovac]. | in the process of the immunological approbation of several experimental batches of the triyalent subunit influenza vaccine grippovac, the pronounced immunogenicity of the antigens of all strains contained in the vaccine was established; most of the vaccinees were found to retain sufficiently high antibody titers for a year, and the essential total increase of antibody titers was found to occur after a single booster immunization. the serological checking of the diagnosed cases of influenza among ... | 1986 | 2938372 |
| [influenza morbidity in the kazakh ssr 1977-1984]. | in 1977-1984, 6 epidemic outbreaks of influenza were recorded in the republic of which 2 were due to influenza a (h1n1), 2 to a (h3n2) and 2 to influenza b virus. the epidemics of influenza h1n1 (1977-1978, 1981) and h3n3 (1979-1980, 1983) were characterized by gradual decrease of their intensity as manifested by lowering of the morbidity rate and frequency of virus isolation. on the contrary, epidemics of influenza b showed a certain trend to increase. an important feature of the epidemics etio ... | 1986 | 2945325 |
| [epidemiological surveillance of influenza based on research data on collective immunity]. | in 1976-1984 the dynamic study of communal immunity to influenza a and b virus strains was made with the aim of the etiological prognostication of influenza epidemic. on the basis of the study of the immune status of the adult and child population to the virus strains, actually circulating in october-november, the possibility of prognosing the tendency in the development of the epidemiological situation in influenza in the following year was established. | 1986 | 2948353 |
| laboratory studies of the 1984 influenza epidemic on the witwatersrand. | a particularly severe outbreak of influenza occurred on the witwatersrand from may to august 1984, caused sequentially by influenza a (h3n2), b/influenza and influenza a (h1n1) viruses. although the precise extent of the infection was impossible to determine, valuable anecdotal information was provided by a network of sentinel sampling stations in private practices, clinics and hospitals, representing a cross-section of population groups on the witwatersrand. this active surveillance programme w ... | 1986 | 3798269 |
| influenza activity in czechoslovakia and the ussr, 1980-1985. | between 1980 and 1985, czechoslovakia had experienced 4 and the ussr 3 major influenza outbreaks. of the 3 epidemic outbreaks in the ussr, 2 were associated with influenza b virus (in the 1980/81 and 1983/84 seasons) and 1 with influenza a virus of the h3n2 subtype. in the ussr, influenza a (h1n1) virus never predominated as a cause of epidemic during the 5 years period. in czechoslovakia, 2 epidemics (in the 1980/81 and 1983/84 seasons) were due to influenza a (h1n1) virus. the epidemic in the ... | 1986 | 3805712 |
| [activity of virion rna-polymerase in influenza a and b virus variants with different pathogenicities for mice]. | rna polymerase activities in parental strains of influenza a and b viruses nonpathogenic for mice and their pathogenic variants have been studied. the parental strains are a/seal/massachusetts 1/80, a/ussr 05/81, a/philippines 2/82, b/singapore 222/79. the rna polymerase activity has been also studied in recombinant strains obtained by crossing various parental strains, one of which is pathogenic for mice (ar/pr 8/34), and having different degrees of pathogenicity. the nonpathogenic viruses had ... | 1986 | 3807928 |
| effect of heating and adsorption of complement on the antiviral activity of normal sera against inhibitor-resistant influenza virus. | 1986 | 3824904 | |
| [operative assessment of the influenza situation based on a complex accounting of standardized indices of incidence and data on rapid diagnosis]. | the paper described a method allowing most objective and operative evaluation of the influenza situation in the autumn-winter period, the detection of the onset of influenza epidemic in a given population area, and characterization of the intensity of the epidemic. the development of a more accurate method of operative evaluation of the influenza situation is necessary because influenza is one of widely prevalent virus diseases which still plays a significant role in human pathology and simultan ... | 1986 | 3825088 |
| [effective stabilizer for preparing antibody erythrocyte diagnostic agents for influenza a and b viruses]. | a method for preparation of erythrocyte antibody diagnosticums capable of differentiating in pha test the type and subtype appurtenance of influenza virus strains was developed on the basis of amidol sensitization of erythrocytes with immunoglobulin preparations and the use as a stabilizing agent of nonionic detergent triton x-100. the method is simple, highly sensitive, reproducible, and may be used at virological laboratories of practical health institutions. | 1986 | 3825090 |
| [inhibition of several strains of influenza virus type a and b by phenolic polymers]. | ten synthetic polymers of diphenolic compounds (kop, hykop, chop, 3,4-dhtop na-adrop, nh4-adrop, na-noradrop, nh4-noradrop, genop, and 2,5-dhtop) as well as two phenolic polymers of natural origin (na-humate, nh4-humate) were tested for their effectiveness on several strains of influenza virus type a and b. the allantois-on-shell system was used for primary screening. virus multiplication was assessed by means of the infectious titer. all substances tested were found to exert inhibitory effects ... | 1986 | 3814107 |
| demonstration of an immunosuppressive action of detergent-disrupted influenza virus on the antibody response to inactivated whole virus vaccine. | in a series of experiments performed in hamsters and mice, administration of mixtures of detergent-disrupted (sv) influenza a x49 (h3n2) virus and inactivated x49 whole virus (wv) vaccine induced lower serum antibody titres than equivalent or lower doses of wv vaccine alone. this reduction in antibody titre was also observed using influenza a (h1n1) and influenza b (b/hong kong/8/73) sv and wv vaccine preparations. the results suggested that sv preparations can suppress the serum antibody respon ... | 1987 | 3819697 |
| response of epithelial cells of the choroid plexus in the ferret model for reye's syndrome. | the structural integrity of epithelial cells of the lateral choroid plexus tissues from the ferret model for reye's syndrome was examined by transmission electron microscopy after the animals were inoculated intranasally with influenza b, were administered aspirin, and/or were fed an arginine deficient diet singly and in combination. no cellular alteration in the choroidal epithelium was caused by influenza b nor by aspirin, however, the synthetic diet produced random intercellular edema. the st ... | 1987 | 3821066 |
| influenza b virus reinfection. | four outbreaks of influenza b infection occurred in houston, texas in the years 1976-1984. in the houston family study, age-related infection and illness rates in the recent two epidemics resembled those reported previously. a total of 118 persons, including 35 children followed from birth, were followed longitudinally through this entire period and 331 persons were studied through at least two outbreaks. fifty-nine (88%) of 67 children studied for four outbreaks were infected and 25% had a seco ... | 1987 | 3826038 |
| infectious influenza a and b virus variants with long carboxyl terminal deletions in the ns1 polypeptides. | an influenza a virus, a/turkey/oregon/71, was shown by protein gel analysis to code for an ns1 protein approximately half the size of those of other influenza a viruses. sequence analysis of the ns gene of this virus revealed a 10 nucleotide deletion resulting in an ns1 protein of only 124 amino acids. this truncated ns1 polypeptide retained its karyophilic pattern as detected by indirect immunofluorescence analysis of virus infected cells. also, a/turkey/oregon/71 virus grew to high titer in em ... | 1987 | 3811235 |
| effects of site-specific mutation on structure and activity of influenza virus b/lee/40 neuraminidase. | a cdna copy of the neuraminidase (na) gene of a high-growing reassortant influenza virus which has the hemagglutinin of b/hong kong/8/73 and the na of b/lee/40 was cloned into plasmid puc 9 and subcloned into a late-replacement sv40 vector so that the na gene could be expressed in eukaryotic cells. the expressed protein was antigenically and enzymatically active. to study structure-function relationships in the b/lee na, particularly in comparison to the known structure of influenza a (n2) na, s ... | 1987 | 3811237 |
| possible association of mycoplasma and viral respiratory infections with bacterial meningitis. | the presence of viral infection was evaluated in 160 children older than three months with bacterial meningitis who were admitted to children's medical center or parkland memorial hospital, dallas, tx, between october 1979 and march 1982. results were compared with a single serologic specimen in 138 children without meningitis. a recent history of upper respiratory infection was obtained from 60% of patients, including 10/13 with pneumococcal, 9/16 with meningococcal, and 77/131 with haemophilus ... | 1987 | 3812456 |
| toxic shock syndrome. a newly recognized complication of influenza and influenzalike illness. | nine cases of severe hypotension or death compatible with toxic shock syndrome (tss) as a complication of influenza and influenzalike illness were identified in minnesota with onsets between jan 2, 1986, and feb 23, 1986, in which five of the patients died. during this time, an influenza outbreak was occurring in the state. cultures of respiratory secretions were performed in eight patients; staphylococcus aureus was isolated from all of them. seven s aureus isolates were available for determina ... | 1987 | 3806893 |
| segment-specific and common nucleotide sequences in the noncoding regions of influenza b virus genome rnas. | the nucleotide sequences of the 3' noncoding regions of all eight segments of influenza b virus rna and the sequences of the 5' noncoding regions of segments 4-8 were determined in virus strains isolated over a period of 40 years. nearly complete conservation of the noncoding sequences was found. nine nucleotides at the 3' termini and 11 nucleotides at the 5' termini were common to all segments examined. in the region immediately adjacent to the common 3' terminal region, the nucleotides were sp ... | 1987 | 3472232 |
| segment-specific inverted repeats found adjacent to conserved terminal sequences in wound tumor virus genome and defective interfering rnas. | defective interfering (di) rnas are often associated with transmission-defective isolates of wound tumor virus (wtv), a plant virus member of the reoviridae. we report here the cloning and characterization of wtv genome segment s5 [2613 base pairs (bp)] and three related di rnas (587-776 bp). each di rna was generated by a simple internal deletion event that resulted in no sequence rearrangement at the deletion boundaries. remarkably, although several di rnas have been in continuous passage for ... | 1987 | 3479793 |
| [immunity of the populations of the ussr and east germany to reference strains of influenza viruses and the characteristics of a new antigenic variant of the virus]. | in 1985, a new epidemic variant of influenza virus, a/berlin/6/85 (h3n2) was isolated which differed antigenically from the reference a/philippines/2/82 virus. the results of the study of population immunity in adults and children of the ussr and gdr to these virus variants confirm the data on the continuing drift of virus a (h3n2). | 1987 | 3500544 |
| idiotypic analysis of the influenza virus-specific human b cell repertoire. | 1987 | 3501829 | |
| genetics of cold-adapted b/ann arbor/1/66 influenza virus reassortants: the acidic polymerase (pa) protein gene confers temperature sensitivity and attenuated virulence. | the cold-adapted b/ann arbor/1/66 influenza virus (ca b/aa/1/66) expresses temperature-sensitive (ts), cold-adapted (ca) and attenuation phenotypes. reassortants which inherit one or more genes from ca b/aa/1/66 and all other genes from a virulent, wild-type influenza virus, b/houston/1732/76, were produced and evaluated in order to identify the gene(s) responsible for the ts, ca and attenuation phenotypes. only reassortants which inherited the pa gene from ca b/aa/1/66 expressed the ts phenotyp ... | 1987 | 3504545 |
| influenza vaccination with adjuvant ru41740 in the elderly. | 1987 | 2882355 | |
| influenza virus depresses the pfc response of mice by affecting t-cell function. | five influenza virus strains of type a and one strain of type b were used to elicit suppressive effect on the formation of antibody producing cells in response to sheep red blood cells (srbc) both in vivo and in vitro. not only live virus but also the formalin inactivated one exerted immunosuppression (is). although intranasal infection only could cause disease in mice, it exerted no is which, in contrast, occurred after intraperitoneal or intravenous injection of the virus. in nude mice these e ... | 1987 | 2888284 |
| preparation of influenza b virus recombinant strains. | the study of antigenic and biologic properties of influenza b epidemic viruses isolated in 1979 and 1983 and laboratory strain b/lee/40 has revealed some differences in their biologic properties. the most marked changes have been found in the haemagglutinin (ha) and neuraminidase (na) indicating that influenza b viruses underwent dramatic antigenic drifts during the period in question. the strains obtained by genetic recombination have inherited surface antigens of epidemic influenza b/singapore ... | 1987 | 2894141 |
| epidemiology of influenza a and b viruses. use of monoclonal antibodies to analyze viruses from circumscribed epidemics. | 1987 | 2856221 | |
| respiratory viruses in children admitted to hospital in edinburgh 1972-1985. | the temporal incidence of respiratory viruses identified in children admitted to an edinburgh hospital over a period of 14 years, 1972-1985, is described, respiratory syncytial (rs) virus was identified most often, usually (but not in 1979 and 1985) with single peaks of activity in the winter months. influenza virus infections were seen in the winter and spring but we failed to find evidence of interference between rs and influenza virus. of the viruses studied, the parainfluenza viruses were th ... | 1987 | 2822808 |
| [circulation of influenza viruses in northeast romania during the year 1986]. | 1987 | 2825319 | |
| efficiency of immunofluorescence for rapid detection of common respiratory viruses. | rapid immunofluorescence (fa) methods for the detection of common respiratory viruses were compared with culture results over a 3-year period to assess the relative efficiency of fa in a clinical laboratory setting. for respiratory syncytial virus, efficiencies were high (sensitivity, 90 to 95%; specificity, 92 to 95%). the sensitivity of fa for detection of parainfluenza virus type 1, parainfluenza virus type 3, influenza a virus, and adenoviruses ranged from 28 to 63%, but specificities for th ... | 1987 | 3029168 |
| early testing of cell cultures for detection of hemadsorbing viruses. | hemadsorption of primary monkey kidney cell cultures was commenced at 1 day after inoculation to evaluate how rapidly influenza a virus, influenza b virus, and parainfluenza virus types 1, 2, and 3 could be detected by this method from respiratory specimens. overall, 38% of all isolates could be detected within 24 h of inoculation, and 69% could be detected within 48 h. all influenza a viruses and all but one influenza b virus were detected by day 3. | 1987 | 3029173 |
| serum folate in viral and mycoplasmal infections. | the concentration of serum folate in 260 patients with viral and mycoplasmal infections was determined (305 samples). in 60% the serum folate concentrations were found to be below 3 micrograms/l. the incidence of low serum folate varied slightly. according to the infections diagnosed, low values were: for influenza a 50% (50 patients), influenza b 42% (45 patients), human parvovirus 67% (76 patients), rubella 62% (13 patients), infectious mononucleosis 60% (15 patients), mycoplasma pneumoniae 73 ... | 1987 | 3033086 |
| effect of upper respiratory infection on hearing in the ferret model. | in an effort to develop an adult animal model for acquired viral-induced hearing loss, three groups of mature ferrets were inoculated intranasally with respiratory viruses (influenza a/port chalmers, influenza b/mass, and parainfluenza i), which have been implicated as causative agents in idiopathic sudden hearing loss (ishl). all ferrets challenged with influenza a/port chalmers (a/pc) exhibited clinical signs of infection, but neither of the other two groups exhibited such signs. conductive an ... | 1987 | 3039863 |
| monoclonal antibodies detect m-protein epitopes on the surface of influenza virions. | various data obtained with activable hydrophobic probes, proteolytic treatments and anti m-protein polyclonal antibodies strongly suggest that m-protein of influenza a is an integral part of the lipid bilayer of native virions and somehow spans at the surface of the virions. therefore we have looked for the presence of m-protein epitopes on the surface of influenza a virion by using four type a m-protein monoclonal antibodies. we developed a specific and sensitive competition elisa where intact ... | 1987 | 2440414 |
| [analysis of the antigenic specificity of the neuraminidases of influenza b viruses isolated in different years]. | the antigenic structure of neuraminidases of influenza b viruses isolated in 1940-1984 was studied. lectin test has first been employed for analysis of influenza b virus neuraminidase. the antigenic composition of neuraminidases of these viruses was shown to be different. the strains isolated in the epidemic of 1983-1984 underwent further drift of the neuraminidase component and represent a heterogeneous group in this respect. the use of monospecific antiserum to purified neuraminidase helped sp ... | 1987 | 2445105 |
| [involvement of the afterbirth in influenza]. | light- and fluorescence-microscopy examinations of 186 placentas were carried out, with concurrent determination of placental interferon, isolation of influenza virus, and serologic tests of maternal and fetal blood, and amniotic fluid. in 32 of the cases, placentitis caused by serotype a or b of influenza virus was present, characterized by hyperplasia and subsequent destruction of amniotic cells, trophoblast, decidual cells, and vascular endothelium, by the presence of influenza antigens, fuch ... | 1987 | 2446593 |
| enzymological characteristics of avian influenza a virus neuraminidase. | neuraminidases of 18 strains of avian influenza a virus were examined by both colorimetric and fluorometric assays using fetuin and 4-methylumbelliferyl-n-ac-alpha-d-neuraminide as substrates, respectively, to compare them with those of human influenza a and b viruses. the ratios of the neuraminidase activity of avian influenza virus measured by the colorimetric assay method to that measured by the fluorometric assay were distributed in the range of 2.4-20.3. the enzyme of avian influenza virus ... | 1987 | 2451112 |
| influenza b virus model of reye's syndrome. evidence for a nonpermissive infection of liver and brain. | nonpermissive or abortive viral infections seldom have been recognized as damaging to organs. concentrated infectious influenza b/lee virus injected intravenously into balb/c mice causes a microvesicular fatty metamorphosis of the liver and produces many features of reye's syndrome. evidence for a nonpermissive infection in brain and liver includes the following points: (a) no viral replication occurs in either organ; (b) no inflammation develops; (c) no virions are seen by electron microscopy; ... | 1987 | 3795869 |
| prevention and control of influenza. | 1987 | 3108649 | |
| update on influenza activity--worldwide. | 1987 | 3118165 | |
| [activity of influenza virus in the metropolitan region of panama city, 1976-1986]. | 1987 | 3423321 | |
| novel pyrazolo[3,4-d]pyrimidine nucleoside analog with broad-spectrum antiviral activity. | a novel nucleoside analog, 4(5h)-oxo-1-beta-d- ribofuranosylpyrazolo[3,4-d]pyrimidine-3-thiocarboxamide (n10169), was evaluated in cell culture and in animals for antiviral activity against dna and rna viruses. the compound was highly active against strains of adeno-, vaccinia, influenza b, paramyxo-, picorna-, and reoviruses, with 50% inhibition of virus-induced cytopathology at 1 to 10 microm. lesser or no antiviral effects were observed against herpes simplex, cytomegalo-, corona-, influenza ... | 1987 | 3435102 |
| epidemiological research on the phenomenon of the influenza herald wave. | 1987 | 3437042 | |
| irregular appearance of antiviral activity of complement in the hemagglutination-inhibition test. | 1987 | 3439033 | |
| serological testing of human blood samples for infectious diseases in the abeokuta and the minna hospitals/nigeria. | in serological investigations undertaken in two hospitals in nigeria a total of 188 blood samples were examined and the following positive reactions for various diseases found: malaria 100%, leishmaniasis 9.5%, biharziasis 2.1%, yersinia 16.4%, legionella pn. 9%, gonorrhea 6%, syphilis 6.9%, measles 65.4%, rubella 84%, cytomegalic 78.2%, herpes simplex 67%, varicella 30.8%, resp. sync. virus 34.6%, influenza a 57.4%, influenza b 73.9%, para-influenza 1, 2, 3, 20.7%, 16.5%, 52.6%, adenovirus 25%, ... | 1987 | 3443750 |
| influenza a and b antibody status in tanzania. | sera from 200 babies and young children and from 205 mother-newborn pairs were tested for haemagglutination inhibiting antibody against three a-h1n1, one a-h2n2, four a-h3n2, and two influenza b viruses. the results indicated that a higher concentration of antibody against all influenza a and b viruses tested was found more frequently in maternal sera than in neonatal sera. high prevalences of antibody and high geometric mean titres against the a-h2n2-1957 and a-h3n2-1968 viruses from the eras 1 ... | 1987 | 3445328 |
| influenza vaccination in a boarding school population. | 1987 | 3451775 | |
| intraepidemic heterogeneity of influenza b viruses isolated in 1986. antigenic and biological characteristics. | 1987 | 3455655 | |
| subtype-specific identification of influenza virus in cell cultures with fitc labelled egg yolk antibodies. | we report on results obtained with a direct immunofluorescence test for subtype-specific identification of influenza virus in detached cells of mdck cultures after inoculation of 281 clinical specimens from patients with influenza-like disease. influenza virus antibodies were produced in eggs from immunized hens and labelled with fitc. in 157 cases cpe was found in mdck cells. a total of 57 cases of influenza a (h3n2), 86 cases of influenza a (h1n1), and 14 cases of influenza b were identified. ... | 1987 | 3547056 |
| [isolation and study of the properties of igg from antisera to influenza virus proteins]. | igg to internal (np, m) and external (ha, na) proteins of influenza virus were isolated from immune rabbit sera using caprylic acid. the igg retained their specificity and activity, worked in hi, lectin test, and enzyme-immunoassay. igg migrated towards cathode in electrophoresis on acetate cellulose. electrophoresis in polyacrylamide gel revealed a heavy chain (55,000) and a light chain (25,000) in igg molecule. different methods revealed changes in igg structure after lyophilization. the possi ... | 1987 | 3554755 |
| [humoral immunity indices of chronic alcoholism patients]. | sera obtained from 642 patients with chronic alcoholism and 400 sera from healthy donors, collected in different regions of the ussr (moscow, the kirghiz ssr, transcarpathian province, the northern caucasus), were studied. out of all patients with chronic alcoholism whose blood sera were examined, persons aged 20-30 years constituted 22%, 31-40 years, 41.8%, 41-50 years, 27.5%, above 50 years, 8.7%. the results of the study of the immune structure of these patients with respect to the causative ... | 1987 | 3564781 |
| acute respiratory disease associated with influenza epidemics in houston, 1981-1983. | virological surveillance at "sentinel" clinics in houston has demonstrated that the annual peak in the number of visits for acute respiratory disease (ard) always coincides with the peak of influenza virus activity. a survey of visits to a health maintenance organization between 1981 and 1983 allowed us to calculate the age-specific rates of visits for ard during two moderately severe influenza epidemics (1981-1982 and 1982-1983). during the most intense period of influenza virus activity the ra ... | 1987 | 3572033 |
| inactivation of influenza b virus by normal guinea-pig serum. | normal guinea-pig serum (gps) lacking detectable antiviral antibody efficiently neutralized the infectivity of influenza b virus grown in chick embryos or mdck cells. the inhibitor was heat-labile and sensitive to trypsin digestion. this beta-like inhibitor required ca2+ and the complement components c1 and c4 for its activity. in contrast, gps did not inactivate influenza a virus. influenza b virus from which the neuraminidase activity of the spikes on the viral envelope had been eliminated by ... | 1987 | 3572357 |
| trivalent influenza vaccine in patients on haemodialysis: impaired seroresponse with differences for a-h3n2 and a-h1n1 vaccine components. | one hundred and one patients on haemodialysis, 21 patients on peritoneal dialysis and 30 healthy controls received a trivalent split vaccine containing 15 micrograms haemagglutinin of a recent influenza a-h3n2, influenza a-h1n1 and influenza b strain, respectively. antibody production after four weeks was determined by the haemagglutination-inhibition test and expressed as response rate, protection rate and overall mean fold increase. the patients on haemodialysis revealed a diminished serorespo ... | 1987 | 3577356 |
| relative antigenicity in mice of h1n1, h3n2 and b strains present in inactivated influenza virus vaccines. | the results of a study on serum hai and neutralizing antibodies induced in mice by whole influenza virus vaccines containing a/brazil/11/78 (h1n1), a/bangkok/1/79 (h3n2) and b/singapore/222/79 viruses are reported. according to the gmt of hai, the antigenic potency of the three vaccine strains appear to be different. the a/brazil/11/78 antigen induced the lowest hai antibody responses and the a/bangkok/1/79 antigen the greatest. this behaviour, with a few exceptions, was noted regardless of the ... | 1987 | 3582601 |
| studies on human beings inoculated with influenza vaccine and bearing hi antibody against actual prevailing strains. | 1987 | 3584410 | |
| outbreak of respiratory illness on board a ship cruising to ports in southern europe and northern africa. | a large outbreak of influenza-like and diarrhoeal illness took place over a period of 21 days in april 1984 on board a ship cruising to ports in southern europe and northern africa. a cohort study of the 418 passengers was made by postal questionnaire and personal interview. of the 391 passengers who were interviewed or who returned a questionnaire, 335 (86%) were affected. of the ill passengers, 295 (88%) had an influenza-like illness. these included 20 with signs of lower respiratory tract inf ... | 1987 | 3585036 |
| [treatment of patients with influenza and acute respiratory viral infections using mefenamic acid]. | 1987 | 3590689 | |
| [results of a study of new preparations of inactivated whole-virion influenza vaccines for the protection of children in the ussr]. | the safety, reactogenic properties and antigenic potency of inactivated whole-virion influenza vaccines produced in the ussr were studied on 1,117 schoolchildren in limited coded clinico-immunological observations. inactivated chromatographic influenza vaccine obtained from strain a/texas/1/77 (h3n2) and a variant of this vaccine, developed specially for children and obtained from strains a/texas/1/77 and b/leningrad/76, were used for immunization. both preparations were introduced intradermally ... | 1987 | 3591124 |
| [involvement of the cardiovascular system in patients with influenza caused by type b virus]. | 1987 | 3599832 | |
| hepatic lipid abnormalities in a chemical/viral mouse model for reye's syndrome. | we have examined hepatic lipid profiles in a mouse model for reye's syndrome (rs) in which young animals are exposed to nontoxic doses of an industrial pesticide emulsifier and subsequently are infected with sublethal doses of mouse-adapted human influenza b (lee) virus (flub). the purpose of this study was to determine whether liver lipid content was altered in the mice, the time course of any changes, and whether lipid changes were consistent with liver pathology. neonatal mice exposed dermall ... | 1987 | 3600198 |
| [the 1985 influenza epidemic in a pediatric practice]. | because it is not possible to distinguish clinically influenza from other respiratory infections, virological methods have to be used to establish the influenza etiology. nasopharyngeal swabs from 202 children with respiratory symptoms were taken. influenza a virus (h3n2) was isolated from 44 children, influenza a virus (h1n1) from 61 children and influenza b virus from 13 children. the maximal activity of the two influenza a virus subtypes was different. the following features permitted the cla ... | 1987 | 3600670 |
| primary structure of the polymerase acidic (pa) gene of an influenza b virus (b/sing/222/79). | a dna copy of influenza b/singapore/222/79 viral rna segment 3 containing the gene coding for the polymerase acidic (pa) protein has been cloned in escherichia coli plasmid pbr322, and its nucleotide sequence has been determined. the cdna clone was incomplete and contained 1810 nucleotides (nt 396 to 2205). the remaining nucleotide sequence at both 5' and 3' ends of b pa gene was obtained by sequencing the viral rna (minus sense) and messenger rna (plus sense) using oligonucleotide primers. the ... | 1987 | 3604058 |
| [physiochemical properties of purified and virion neuraminidases of the influenza b viruses]. | a method for isolation of neuraminidase using pronase has been developed. purified preparations have been recovered from two influenza b virus strains, b/mass/3/66 and b/ussr/14/80. physico-chemical properties of neuraminidases were compared; optimal conditions for the determination of neuraminidase activity of these strains were determined. strains differences in thermostability, optimal ph, specificity to substrates were established. neuraminidases, isolated or present in virions, were shown t ... | 1987 | 3604184 |
| [clinical evaluation of trivalent influenza virus split vaccine in patients with cardiovascular diseases]. | 1987 | 3604322 | |
| [significance of legionella pneumophila in human respiratory pathology]. | the etiological structure of acute pneumonia and acute respiratory diseases was studied with a view to establishing the proportion of l. pneumophila among other causative agents of such diseases. a total of 299 patients were examined over time. the etiological diagnosis based on the data of serological examination was made in 70.6% of the patients with acute pneumonia and in 65% of the patients with acute respiratory viral infections and influenza. in the etiology of pneumonia, the leading role ... | 1987 | 3604505 |
| [etiology of acute pneumonias in an organized collective]. | in this work the immune structure of an organized group with respect to acute respiratory infections and the etiological structure of cases of acute pneumonia was studied. the sera taken from 602 persons were tested for the presence of antibodies to 14 infective agents of the viral, bacterial and mycoplasmal nature. the data indicate that all these agents circulate in the group under study with the prevalence of influenza a (h3n2), influenza b and group iii parainfluenza viruses. among etiologic ... | 1987 | 3604507 |
| upper respiratory tract viral infection and mucociliary clearance. | twenty-six normal volunteers were exposed to rhinovirus or influenza b virus. measurement of nasal mucociliary clearance, ciliary beat frequency, percent of epithelium ciliated, ciliary ultrastructure and nasal transmucosal potential difference were made before exposure, during viral incubation and at the time of expected overt infection. ten volunteers failed to become infected, six were subclinically infected and nine were infected with symptoms. there were no significant differences between t ... | 1987 | 3609187 |
| unusual outbreak of influenza a in a wyoming nursing home. | an explosive outbreak of influenza a (h3n2) occurred during early february 1985 among the 55 residents of a nursing home in douglas, wyoming. thirty of the 55 (55%) had febrile respiratory illnesses. thirty-six (65%) had received influenza vaccine. the attack rate was 84% in unvaccinated and 39% in vaccinated persons. vaccine efficacy was estimated to be 54%. there were eight cases of pneumonia in unvaccinated and four in vaccinated persons, three deaths in unvaccinated and one death in vaccinat ... | 1987 | 3611565 |
| leads from the mmwr. prevention and control of influenza. | 1987 | 3612978 | |
| children hospitalized with influenza b infection. | an outbreak of influenza virus type b infection occurred in philadelphia from december, 1985, to april, 1986. during this epidemic 24 patients were admitted to children's hospital from whom influenza b was isolated from routine respiratory viral cultures. all were younger than 3 years of age. clinical findings included fever (greater than or equal to 38 degrees c) (88%), rhinorrhea (62.6%), cough (50%), otitis (50%), rhonchi (42%), vomiting (38%), diarrhea (33%), rales (21%), pharyngitis (13%) a ... | 1987 | 3615069 |
| influenza at lowry air force base in denver, 1982-1986. | 1987 | 3624907 | |
| comparison of one- and two-dose regimens of influenza vaccine for elderly men. | in november and december 1984, 102 male residents of a long-term care facility (mean age 74.6 [extremes 59 and 97] years) received 0.5 ml of trivalent inactivated whole-virion influenza vaccine, containing 15 micrograms of the hemagglutinin of each of a/philippines/2/82 (h3n2), a/chile/83 (h1n1) and b/ussr/83. a second dose of the vaccine was administered to a subgroup of 55 randomly chosen subjects 8 weeks later. serum samples were collected from all the subjects before and 4, 8, 12 and 16 week ... | 1987 | 3651943 |
| immunization of elderly people with two doses of influenza vaccine. | a total of 104 elderly patients were immunized with one or two doses of the commercial 1985-1986 inactivated influenza vaccine formulation. two types of vaccines (split virus [sv] vaccine and whole virus [wv] vaccine) and one or two doses 1 month apart were given. no difference in local or systemic reactions was noted among the four groups. the reciprocal geometric mean hemagglutination inhibition antibody titers against influenza a/philippines/82 (h3n2) after one or two doses were: 78 for sv va ... | 1987 | 3654947 |
| epidemiologic particularities of influenza in 1986 in a large urban centre of romania. | the study presents the evolutive peculiarities of the epidemiologic influenza process in 1986 in a large urban centre in romania, inferrable from the active control by a complex methodology based on clinical, epidemiologic and laboratory investigations. the prevalent part of a (h1n1 and h3n2) and b influenza viruses in causing seasonal morbidity risings is being stressed. a (h3n2) and b influenza viruses determined an epidemic rising during the first trimester and a (h1n1) and a (h3n2) during th ... | 1987 | 3660584 |
| [comparative study of the rna-polymerase activity of non-pathogenic and pathogenic influenza viruses a and b]. | activity of rna polymerase was studied in original non-pathogenic for mice viruses of influenza a and b (a/seal/massachusetts 1/80, a/ussr 05/81, a/philippines 2/82 and b/singapore 227/79) and of their pathogenic derivatives. all the non-pathogenic viruses studied exhibited the low rate of transcriptase activity. pathogenic derivatives of these strains exhibited higher activity of rna polymerase, which was 1.5-3-fold higher as compared with the original strain. during passage of influenza viruse ... | 1987 | 3660748 |
| nucleotide sequences of the pa and pb1 genes of b/ann arbor/1/66 virus: comparison with genes of b/lee/40 and type a influenza viruses. | the complete sequences of the pa and pb1 genome rna segments of b/ann arbor/1/66 virus have been determined. the pa vrna is 2308 bases long. its complementary rna has a single open reading frame of 2187 bases, capable of encoding a pa protein of 726 amino acids with a molecular weight of 83,175 da. the predicted pa polypeptide has an overall net charge of -7.5 at ph 7.0. the pb1 vrna is 2369 bases long. its complementary rna has a single open reading frame of 2277 bases, capable of encoding a pb ... | 1987 | 3660943 |
| the hemagglutinins of the human influenza viruses a and b recognize different receptor microdomains. | a cryptically i-active sialylglycoprotein (glycoprotein 2) isolated from bovine erythrocyte membranes as sendai virus receptor (suzuki, y., suzuki, t. and matsumoto, m. (1983) j. biochem. 93, 1621-1633) contains n-glycolylneuraminic acid (neugc) as its predominate sialic acid and exhibits poor receptor activity for a variety of influenza viruses. enzymatic modification of asialoglycoprotein-2 to contain n-acetylneuraminic acid (neuac) in the neuac alpha 2-3gal and neuac alpha 2-6gal sequences us ... | 1987 | 3663654 |
| [a study on the epidemic characteristics of influenza in qingdao]. | 1987 | 3664615 | |
| influenza surveillance in pune (india) during 1983-85. | 1987 | 3666849 | |
| two cases of influenza b encephalitis. | 1987 | 3668577 | |
| leads from the mmwr. update on influenza activity--worldwide. | 1987 | 3669252 | |
| [virological and serological diagnosis of influenza using the passive hemagglutination and passive hemagglutination inhibition tests]. | 1987 | 3673027 | |
| influenza b encephalitis. | 1987 | 3686990 | |
| a sero-epidemiological study of conventional infectious agents in alzheimer's disease. | serum antibody titres to adenovirus, chlamydia group b, coxiella burnettii, cytomegalovirus, herpes simplex virus, influenza a, influenza b, measles and mycoplasma pneumoniae were measured in 33 patients with a clinical diagnosis of alzheimer's disease, and in 28 non-demented controls suffering from functional psychiatric disorders. no statistically significant differences were found between the patients and controls, and it is concluded that these agents play no role in the aetiology of alzheim ... | 1987 | 3687571 |
| effect of influenza b virus on nutrient transport in cultured epithelial cells. | the possibility that influenza virus could induce changes in membrane permeability to nutrients ordinarily concentrated within the cell was examined. madin-darby canine kidney cells were infected with egg-grown influenza b virus at 37 degrees c and ph 7.4 (a condition in which influenza virus enters cells by endocytosis). control cells were mock-infected with allantoic fluid from chick embryos. transport of phosphate, 2-deoxyglucose, and alpha-aminoisobutyric acid was measured at various interva ... | 1987 | 3695411 |
| economical laboratory support system for influenza virus surveillance. | when increases in influenzalike illnesses were first detected during the 1984 to 1985 and 1985 to 1986 influenza seasons, throat swab specimens were mailed by physicians across the united states to one hospital laboratory, and each specimen was inoculated into a single tube of cell culture. of 165 specimens, 52 (32%) were positive for influenza a or b virus within 3 days of receipt when tested by fluorescence microscopy, permitting positive results to be received by the physicians within 1 week ... | 1987 | 3294893 |
| [the cotton rat (sigmodon hispidus) as an experimental model for studying viruses in respiratory tract infections. ii. influenza viruses types a and b]. | 1987 | 3295428 | |
| [detection and identification of host cell antigens in the composition of influenza b virus]. | two heterogeneous antigens, forssman antigen and an antigen similar to human group a antigen, were detected by enzyme-immunoassay in cells of normal chick embryo camn and mdck culture (dog kidney). both these antigens were associated with purified influenza b virus preparations reproduced in these cultures since the variants under study actively reacted with antibodies both to forssman antigen and to human a antigen. serological differences between the variants grown in different cell systems we ... | 1987 | 3300030 |
| [results of coded trials of the activity of the trivalent subunit influenza vaccine grippovak in moscow kindergartens in december 1983 through the 1st quarter of 1984]. | during the autumn-winter epidemic of influenza-like diseases in december, 1983--first quarter, 1984, in moscow commissioned coded observations on the effectiveness of prophylactic vaccination against influenza of 3-7-year-old children with a preparation "grippovak se-azh" were carried out in day-care centers. in the previous large-scale trials, 1981-1984, the "grippovak" had been evaluated positively as a completely harmless, serologically and immunologically active preparation reducing 3-3.5-fo ... | 1987 | 3300032 |
| infectivity of influenza b virus in cultured human muscle. | severe muscle symptoms, particularly in children, are frequently associated with influenza b virus infection. in this study we examined the effects of influenza b virus (lee strain) on cultured human muscle by light and electron microscopy (em), immunofluorescence, hemadsorption and plaque assays. muscle injury was also evaluated by the appearance of muscle-specific creatine kinase (ck) in the culture medium. by fluorescence immunocytochemistry viral antigen was demonstrated in muscle cell nucle ... | 1987 | 3300131 |
| influenza a and b virus igg and igm serology by enzyme immunoassays. | enzyme immunoassays (eia) for igg and igm antibodies against influenza a and b virus are described. one hundred and seven subjects with a clinical diagnosis of acute respiratory infection (influenza, bronchitis or pneumonia) were selected for this study during two epidemics of influenza a which occurred in finland in 1983 and 1985. paired sera and nasopharyngeal secretions were obtained from all subjects. the sera were tested for influenza a and b antibodies by igg and igm eias and by complement ... | 1987 | 3301380 |
| influenza b in households: virus shedding without symptoms or antibody response. | in the fall of 1983, 53 households were enrolled in a double-blind trial of alpha 2-interferon as an intranasal spray to prevent common colds. during the winter/spring of 1984, 26 households were infected with influenza type b, as shown by isolation of the virus (19 households) and/or significant antibody titer rises (seven households). interferon did not prevent influenza b infection or modify resulting illness. of 37 persons shedding virus, 12 were asymptomatic. all were older than age 12 year ... | 1987 | 3303918 |
| efficacy of high dose-short duration ribavirin aerosol in the treatment of respiratory syncytial virus infected cotton rats and influenza b virus infected mice. | fifteen to 20 mg/ml ribavirin administered as a small particle aerosol for 10-18 h per day is currently the regimen generally used to treat experimental or naturally-occurring respiratory syncytial (rs) or influenza virus infections in humans. to determine if such prolonged treatment schedules could be reduced, cotton rats and mice were inoculated with rs or influenza b virus, respectively, and then treated with different concentrations of ribavirin small particle aerosols. aerosols generated fr ... | 1987 | 3304159 |
| oral ribavirin treatment of influenza a and b. | a loading dose and short-term administration of oral ribavirin significantly improved symptoms and signs of influenza type a or b infection in 25 patients. the antiviral effect was not significant. no adverse clinical effects or significant laboratory values were observed. oral treatment of patients with influenza a or b infection might be possible with ribavirin. | 1987 | 3307623 |
| [the circulation of influenza virus in human communities subjected to the action of noxious chemical substances]. | investigations were conducted during 1985 and 1986 years on the effect of some noxious chemicals on the influenza virus circulation in an industrial enterprise community. the presence of influenza virus type a (h1n1), a (h3n2) and b was revealed by immunofluorescence in exfoliated cells collected from nasopharynx. the kinetic of type specific hemagglutination inhibiting antibodies was followed monthly. chick embryos were used to isolate influenza virus strains. meaning of the results is discusse ... | 1987 | 3310379 |
| comparison of the immune response to variant influenza type b hemagglutinins expressed in vaccinia virus. | to compare the immune response induced by influenza hemagglutinin (ha) variants differing by a single amino acid, the genes for each ha variant were cloned and expressed in vaccinia virus. these variant ha genes have been previously described as being present exclusively in either egg-derived or mdck cell-derived subpopulations of influenza b/england/222/82 virus. by using this approach we were able to vaccinate animals with homogeneous preparations of these viral antigens and thus circumvent th ... | 1987 | 3318092 |
| [immunoenzyme test system based on f(ab)2-antibody fragments for demonstrating influenza virus hemagglutinin]. | 1987 | 3318135 | |
| use of single radial haemolysis for assessing antibody response to influenza virus vaccines in animals. | the value of the single radial haemolysis (srh) test as a possible replacement for the haemagglutination-inhibition (hai) test for the estimation of antibodies against influenza was assessed in three animal models. the serum antibody response was measured by both assay systems; correlation of the two tests was assessed using regression analysis. the study showed that when the response to a single immunisation was determined, the ferret model gave satisfactory correlation of srh and hai, whilst i ... | 1987 | 3323861 |
| the specificity of serum antibodies to the haemagglutinin of influenza b viruses induced by vaccination. | 1987 | 3324992 | |
| [reye syndrome]. | clinical course, laboratory findings and histopathological features of reye's syndrome as described. etiological and pathogenetic aspects are still under discussion although a viral infection preceding reye's syndrome is a very common finding. preceding influenza b, influenza a and varicella infections were most often seen in the united states. a genetic disposition seems to exists in some cases. exogenic factors of pathogenetic relevances are aflatoxin, emulging agents, insecticides, paracetamo ... | 1987 | 3317005 |