Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| rapid diagnosis of varicella-zoster virus infection by direct immunofluorescence. | laboratory results were reviewed for 47 patients who had skin lesions that had been simultaneously examined by viral culture and direct immunofluorescence for the presence of varicella-zoster virus. immunofluorescence established the diagnosis in 24 of 28 patients (86%) strongly suspected on clinical grounds of having varicella-zoster infection. viral culture was positive in only 10 of 28 patients (36%). skin lesions in 19 patients who had other diagnoses were negative by both tests. direct immu ... | 1980 | 6990743 |
| [clinical picture and pathogenesis of generalized forms of herpes zoster]. | clinical examination of 83 patients with generalized herpes zoster has given the authors grounds to regard this disease as a result of activation of latent varicella-zoster virus. this assumption was confirmed by the results of indirect hemagglutination inhibition tests with 37 serum specimens taken from 18 patients. treatment with antibiotics, the drug proper-myl, and by dehydration was the more effective, the earlier the patients were admitted to the clinic. dehydration, proper-myl and combina ... | 1981 | 7234260 |
| [clinical aspects of the varicella-zoster virus infection]. | 1981 | 7335992 | |
| detection of specific iga antibodies in serum of patients with varicella and zoster infections. | a sensitive solid-phase, enzyme-linked immunosorbent assay (elisa) was developed for detection of serum iga antibodies to varicella-zoster virus (vzv). the antigen consisted of a sonically disrupted extract of vzv-infected human embryo cells. rabbit antihuman iga peroxidase conjugate was used to detect human iga bound to viral antigens. in parallel, igm and igg antibodies to vzv were studied by elisa and by an immunoperoxidase antibody to membrane antigen technique, respectively. vzv iga antibod ... | 1981 | 7298297 |
| septic and aseptic arthritis complicating varicella. | 1981 | 6260891 | |
| adult t-cell leukemia: antigen in an atl cell line and detection of antibodies to the antigen in human sera. | indirect immunofluorescence of certain human sera demonstrated an antigen(s) in the cytoplasm of 1--5% of the cells of a t-cell line, mt-1, from a patient with adult t-cell leukemia (atl), which is endemic in southwestern japan. the antigen was not detected in other human lymphoid cell lines, including six t-cell lines, seven b-cell lines, and four non-t non-b cell lines. the antigen did not show cross antigenicity with that of herpesviruses, including epstein--barr virus, herpes simplex virus, ... | 1981 | 7031654 |
| nosocomial infections in immunocompromised children. | within the last decade several advances in medicine have resulted in extended longevity of children with cancer, cystic fibrosis, certain congenital immunodeficiency disorders, chronic renal diseases and aplastic anemia. forthwith, the population of such immunocompromised children has increased and accounts for a greater portion of the hospital census than heretofore. to avoid emotional, infectious and financial burdens of hospitalization, efforts have been successful in developing ambulatory ou ... | 1981 | 7468624 |
| application of a live varicella vaccine in children with acute leukemia or nephrotic syndrome. | 1981 | 6273490 | |
| the plaque-forming factor for mink lung cells present in cytomegalovirus and herpes-zoster virus stocks identified as mycoplasma hyorhinis. | previous investigation of the ability of cytomegalovirus and varicella-zoster virus to replicate in a variety of cell lines suggested that both virus types plaqued with high efficiency in mink lung cells. however, many of the virus isolates used appeared to be contaminated with mycoplasma. we now report that the observed cytopathic effect is due to a mycoplasma which grows lytically to high titre in mink lung cells, but is difficult to cultivate in cell-free media. the mycoplasma was plaque-puri ... | 1981 | 6271903 |
| structure of varicella-zoster virus dna. | varicella-zoster virus (vzv) dna was prepared from nucleocapsids and from enveloped virions of a laboratory strain (ellen) and directly from the vesicle fluids of patients with zoster infections. vzv ellen nucleocapsid dna was cleaved with 11 different restriction endonucleases and electrophoresed in agarose gels. the restriction profiles of the nucleocapsid dna were identical to those of the dna recovered from purified virions, but differed from those of another vzv strain (km). in vitro-labele ... | 1981 | 6275100 |
| varicella-zoster virus fails to induce immunoglobulin g fc receptors in infected human cells. | 1981 | 6292918 | |
| intrauterine varicella: a report of two cases associated with hyper-a-immunoglobulinemia. | varicella during pregnancy may occasionally harm the fetus. this report described one case of congenital varicella syndrome and another of infantile herpes zoster after maternal varicella in the 16th and 29th week of pregnancy, respectively. a remarkable finding was that both mothers and infants had raised levels of serum iga. this suggests that varicella is prone to lead to congenital disease in infants of pregnant women with an immunologic, perhaps genetically determined abnormality. | 1981 | 6274000 |
| acyclovir: an effective antiviral. | 1981 | 6278279 | |
| herpes zoster ophthalmicus in children (reports of two cases). | 1981 | 6269994 | |
| varicella. | 1981 | 6271007 | |
| restriction endonuclease analysis of the dna from varicella-zoster virus: stability of the dna after passage in vitro. | dna was extracted from nucleocapsids isolated from wi-38 cells infected with two different strains of varicella-zoster virus (vzv). the dnas were treated with each of six restriction endonucleases (ecori, hindiii, bg/i, bg/ii, sal i and bam-hi) and small, but reproducible differences in restriction endonuclease patterns were observed. these strains were passaged in wi-38 cells and in primary guinea-pig embryo (gpe) cells, followed by restriction endonuclease analysis of the dnas. no changes were ... | 1981 | 6271904 |
| varicella-zoster virus infection among cancer patients. | 1981 | 6271032 | |
| [investigations to demonstrate latent viral infection of varicella-zoster-virus in human spinal ganglia]. | 1981 | 6289549 | |
| cytological and immunological examination of cerebrospinal fluid in 9 patients with ramsay hunt's syndrome. | the purpose of the present study was to carry out the immunological and cytological examination of cerebrospinal fluid in 9 patients with ramsay hunt's syndrome. the results obtained were as follows: among the serum immunoglobulins, igg in 1 and igm in 5 of 9 cases increased. the varicella zoster antibody titer was significantly elevated in sera of all 9 cases and in csf of all 7 examined cases. there ws positive fluorescence to varicella zoster virus in 2 (cases 8 and 9) of 4 cases in which csf ... | 1981 | 6267732 |
| xbai, psti, and bglii restriction enzyme maps of the two orientations of the varicella-zoster virus genome. | cleavage of varicella-zoster virus dna with the restriction endonucleases psti, xbai, and bglii resulted in 18, 22, and 20 fragments, respectively. based on the molecular weights and molarities of these fragments, a molecular weight of 84 x 10(6) could be calculated for the varicella-zoster virus genome. in both the xbai and the bglii patterns, four 0.5 m fragments were identified. the arrangement of the fragments was determined by molecular hybridization techniques, and the terminal fragments w ... | 1981 | 6268830 |
| antibody pattern to human cytomegalovirus in patients with adenocarcinoma of the colon. | the role of human cytomegalovirus (cmv) was examined according to serological patterns in 37 patients with adenocarcinoma of the colon (acc). the sera were examined for the presence of igg antibodies by the immunoperoxidase antibody to membrane antigens (ipama) method and by the complement-fixation (cf) test. antibody determinations were also performed by the ipama method for three other members of the herpesvirus group: epstein-barr virus (ebv), herpes simplex virus (hsv) and varicella-zoster ... | 1981 | 6282775 |
| detection of antibody to varicella-zoster virus by competitive and igm-antibody capture immunoassay. | a simple, sensitive, and specific competitive solid phase immunoassay for antibody to varicella-zoster virus (anti-vzv) is described. the assay uses reagents that can easily be prepared and is sparing of viral antigen. using a solid phase coated with sheep igg from a serum raised against human mu-fc, the same reagents will accurately detect anti-vzv igm. the competitive assay divided sera from children from adults into immune and nonimmune groups that closely correlated with a history of previou ... | 1981 | 6271923 |
| [experiences with the elisa at the serodiagnosis of infections with viruses of the herpes-group (author's transl)]. | a commercially available and standardized enzymeimmunoassay was applied at 737 patients in order to diagnose immunologically a recent or reactivated infection with herpes simplex, herpes zoster v. and/or cytomegalovirus. during this course of investigation rises or falls of the titer of virus specific igg between the range of 1 : 320, 1 : 1280 and greater than or equal to 1 : 5120 turned out to mark mainly recent infections with one of the three herpes viruses. statistical evaluations of the tes ... | 1981 | 6268528 |
| immunization of inbred guinea pigs with varicella-zoster virus grown in a syngeneic transformed embryo cell line. | varicella-zoster virus was serially propagated in a chemically transformed and cloned line of embryo cells (designated "104 c1") derived from the inbred strain 2 guinea pig. when strain 2 guinea pigs were immunized with varicella-zoster virus subcultivated in the syngeneic cell line, they produced high-titer virus-specific antiserum which lacked antibody against cellular determinants. this immunization procedure offers both practical and theoretical advantages over prior methods which involved i ... | 1981 | 6268659 |
| varicella-zoster virus vaccine dna differs from the parental virus dna. | the dnas of a varicella-zoster virus vaccine and its parental virus were compared by cscl buoyant density centrifugation and restriction enzyme cleavage analysis. the varicella-zoster virus vaccine dna showed a heterogeneous buoyant profile and altered restriction enzyme cleavage patterns. these changed properties are probably the result of the accumulation of virus containing defective varicella-zoster virus dna during extensive cell culture passage of the vaccine virus. | 1981 | 6270384 |
| [problems of vaccination against herpes viruses (author's transl)]. | 1981 | 6283615 | |
| [on the viral etiology of bell's palsy (an enzyme-linked immunosorbent assay study) (author's transl)]. | in a prospective study paired sera of 14 patients suffering from bell's palsy were examined for antibodies against varicella-zoster virus (vzv), herpes-simplex virus (hsv), cytomegalovirus (cmv) and epstein-barr virus (ebv). for determination of antibodies against vzv, hsv and cmv an enzyme-linked immunosorbent assay was carried out. indirect immunofluorescence was carried out to determine antibodies against ebv. serum samples were taken within 5 days of bell's palsy having been diagnosed and we ... | 1981 | 6285096 |
| [herpes zoster]. | this paper summarizes present knowledge on pathogenesis and therapy of herpes zoster. formerly, zoster was considered a reinfection of a partly immune individual by the varicella-zoster virus localized into a body segment of lowered resistance. recent epidemiological and virological evidence, however, suggests a different mode of pathogenesis: in the course of varicella, vzv migrates via the sensory nerves to the dorsal root ganglia where it remains in an inactive form. it may be reactivated in ... | 1981 | 6281992 |
| a rapid radioimmunoassay using 125i-labeled staphylococcal protein a for antibody to varicella-zoster virus. | a sensitive radioimmunoassay for serum antibody to varicella-zoster virus is described; it uses 125i-labeled staphylococcal protein a and a specially designed immunofiltration apparatus. the assay accurately distinguishes between individuals who are susceptible and those who are immune to infection with varicella-zoster virus. in addition, it can detect passive antibody in recipients of varicella-zoster immune globulin. this radioimmunoassay also detects the heterologous antibody responses that ... | 1981 | 6263987 |
| acyclovir - a review of the preclinical and early clinical data of a new antiherpes drug. | a review of the literature on acyclovir (zovirax), a new antiherpes drug, with particular activity against herpes simplex virus types i and ii and also against varicella-zoster, epstein-barr, cytomegalo and herpes b viruses, is presented. the article deals with 'in vitro' and 'in vivo' efficacy in animals, animal toxicity, latency and resistance, the mechanism of action and early clinical experience. | 1981 | 6280605 |
| immunogenic glycoproteins of laboratory and vaccine strains of varicella-zoster virus. | high-titered antisera were prepared in guinea pigs and rabbits against two strains of varicella-zoster virus (vzv): vzv-32, a low-passage laboratory strain, and vzv-oka, a vaccine strain attenuated by passage in both human and guinea pig embryo cells. when the animal vzv-immune sera, as well as a human zoster serum, were used to precipitate radiolabeled glycoproteins from vzv-infected cells and the immune precipitates were analyzed by polyacrylamide gel electrophoresis and fluorography, it was o ... | 1981 | 6262245 |
| an interchangeable elisa for cytomegalovirus antigen and antibody. | an enzyme-linked immunosorbent assay (elisa) was developed to demonstrate cytomegalovirus (cmv) antibodies and antigen. a nuclear antigen from cmv-infected cells was used for detection of igg and igm antibodies. significant rises of cmv-igg and significant levels of cmv-igm were found in sera from patients with acute cmv only, and not with other herpesvirus infections. cmv antigens were demonstrated in cells and in culture medium by a sandwich or by an inhibition elisa technique. in the sandwich ... | 1981 | 6262352 |
| detection of anti-varicella-zoster virus antibodies in blood donors by automated passive haemagglutination. | 1,219 normal blood donors were screened for anti-varicella-zoster virus antibodies by automated passive haemagglutination (aph) on a technicon 15-channel autoanalyzer. 98 samples (8%) were positive by aph and 92% of these were shown to have antibody titres greater than or equal to 1/16 by indirect immunofluorescence assay (ifa). parallel testing on an additional 265 donors revealed that 11 (4%) individuals had ifa titres greater than 1/16 and 6 of these 11 donors were identified by aph. thus, ap ... | 1981 | 6278772 |
| soluble skin test antigen of varicella-zoster virus prepared from the fluid of infected cultures. | a soluble varicella virus antigen for skin testing was developed using culture fluid from varicella-zoster virus-infected human diploid cells. the culture fluid was centrifuged at a high speed (100,000 g for 2 hr) to remove viral particles, and the supernatant, after heating at 56 c for 30 min, was used as the soluble skin test antigen. no virion or nucleocapsid was found by electron microscopy, and very little 3 h-labeled dna in the soluble antigen hybridized with viral dna. by immunoprecipitat ... | 1981 | 6263986 |
| specific in vitro antibody response to varicella zoster. | peripheral blood mononuclear cells from normal donors were stimulated in vitro by varicella zoster (vz) antigen and antibody measured by an elisa technique. antibody was produced in 14 of 19 individuals. this antibody was specific for vz with no binding to herpes simplex virus (hsv), even when the mononuclear cells were taken from individuals who had circulating antibody to vz and hsv. the failure of antibody production in mononuclear cell cultures from some normals, all of whom had serum antibo ... | 1981 | 6279341 |
| a single serum dilution method for the quantitation of neutralizing antibodies to varicella-zoster virus. | a one-point serum dilution method for determination of neutralizing antibody in human sera to varicella-zoster (v-z) virus instead of the serial serum dilution method was investigated. focus counting was performed under a microscope on day 5 to 6 after inoculation of v-z virus into 6-well plastic trays in which human embryonic lung cells were grown. a table was constructed to estimate the nd50 titers by the per cent reduction of the focus count from the control at only one dilution of test sera. ... | 1981 | 6279092 |
| clinical and laboratory studies of kmcc strain live attenuated varicella virus. | 1981 | 6259644 | |
| determination of immunity to varicella using an enzyme-linked-immunosorbent-assay. | 1981 | 6277288 | |
| preparation of varicella-herpes zoster immunoglobulin. | the efficacy of zoster immunoglobulin in prophylaxis of varicella and herpes zoster is reported by many authors. the screening for zoster's antibodies is performed in the blood donor population and in persons convalescing from herpes zoster. the results show that 25 per cent of blood donors and 83.5 per cent of convalescents, respectively, have cf antibody titer of l6. varicella zoster immunoglobulin prepared by alcohol fractionation has a fluorescent antibody titer of 1,024 and a cf antibody ti ... | 1981 | 6274067 |
| antibodies in oligoclonal immunoglobulins in csf from patients with acute cerebrovascular disease. | thin-layer polyacrylamide gel isoelectric focusing (pag ief) of csf and serum, and subsequent immunofixation with viral and structural brain components followed by autoradiography revealed in eight out of nine selected patients with oligoclonal csf igg and cerebrovascular disease local synthesis within the cns of antibodies against one or more of the viruses tested: six patients against measles, five against herpes simplex virus type 1, and two against varicella virus. this finding may reflect a ... | 1981 | 6274124 |
| biochemical transformation of mouse cells by varicella-zoster virus. | mouse l cells lacking the enzyme thymidine kinase (ltk-) were infected with varicella-zoster virus (vzv). even though virus did not replicate in ltk- cells, the presence of virus antigen could be observed by use of an anti-complement immunofluorescent technique at 4 h post-infection and the vzv-specific thymidine kinase could be detected in vzv-infected ltk- cells. ltk-cells were converted to a tk+ phenotype (ltk+) by infection with cell-associated vzv. clones possessing the ability to grow in s ... | 1981 | 6273503 |
| variation on a theme by fenner: the pathogenesis of chickenpox. | 1981 | 6273782 | |
| comparison of anticomplement immunofluorescence and fluorescent antibody-to-membrane antigen tests for determination of immunity status to varicella-zoster virus and for serodifferentiation of varicella-zoster and herpes simplex virus infections. | the anticomplement immunofluorescence (acif) test was compared with the fluorescent antibody-to-membrane antigen (fama) test for determining varicella-zoster virus antibody levels as a measure of varicella-zoster virus immunity status. the acif test was found to be comparable to the fama test in sensitivity and could be used for examining sera at low dilutions of 1:2 and 1:4. in addition, the acif method proved to be a more economical procedure in terms of antigen required and personnel time nec ... | 1981 | 6273453 |
| differential affinities of 5-(2-halogenovinyl)-2'-deoxyuridines for deoxythymidine kinases of various origins. | 1981 | 6270535 | |
| the immune system in slow disease due to persistent submicrobial (viral) infection. | 1981 | 6270625 | |
| identification of a primate cytomegalovirus group-common protein antigen. | 1981 | 6270897 | |
| cryopreservation of varicella-zoster virions without loss of structural integrity or infectivity. | varicella-zosterer virions present in infected cells or in a cell-free state were freeze-dried without loss of structural integrity of infectivity. generally, yields of greater than 5 log10 foci/ml (infected cells) or greater than 4 log10 pfu/ml (cell-free virus) were recovered from varicella-zoster virus-infected human melanoma cells both before and after lyophilization in phosphate-buffered media containing 0.1-1.0 m sucrose. virus frozen in solutions lacking sugar had little or no residual in ... | 1981 | 6270035 |
| varicella-zoster virus infection of diploid and chemically transformed guinea-pig embryo cells: factors influencing virus replication. | factors influencing the replication of varicella-zoster virus (vzv) in guinea-pig embryo cells were evaluated using both diploid cells (gpec) and a chemically transformed cell line (gpt). wild-type and vaccine strains of vzv were successfully isolated and serially propagated in gpec prepared from early gestation whole embryos (less than 2 cm in length). low passage gpec (less than or equal to 5 subcultivations) were more susceptible to vzv infection than high passage gpec (greater than 5 subcult ... | 1981 | 6270257 |
| vestibular vertigo. a form of polyneuritis? | vestibular vertigo traditionally has been considered to be of viral origin and some forms (acute vestibular neuronitis, acute labyrinthitis, acute vertigo) may be manifestations of a viral cranial polyneuritis. to test this hypothesis, otoneurologic signs and serum complement-fixation titers to herpes simplex and herpes zoster were determined in 16 patients with acute vertigo during their attack and several weeks later. one hundred unselected patients seen for nonotoneurologic problems served as ... | 1981 | 6268853 |
| [the elimination of nonspecific reaction in elisa --for the application of routine serological test on varicella zoster, measles and rubella virus (author's transl)]. | 1981 | 6268717 | |
| differentiation of members of the human herpesviridae family by radioimmunoassay. | many individuals who are seronegative for one member of the human herpesviridae family are strongly seropositive for other members. using sera from such individuals, the radioimmunoassay technique demonstrated absence of antigen-antibody cross-reactions between varicella-zoster virus (vzv) and herpes simplex virus (hsv) at levels of less than one part in 1,000. sera containing antibody to both hsv and vzv were absorbed with antigens of one agent without significantly altering the amount of remai ... | 1981 | 6268545 |
| inactivation of varicella zoster virus in vitro: effect of leukocytes and specific antibody. | inactivation of varicella zoster virus in vitro by nonadherent, mononuclear peripheral blood leukocytes and antibody is described. when leukocytes and specific antibody were incubated with this virus, marked inactivation of the virus occurred. in contrast, leukocytes alone or with serum devoid of varicella zoster antibody caused only a small degree of inactivation of varicella zoster virus. the leukocytes involved appeared not to be monocyte-macrophages or t or b lymphocytes, and only minute amo ... | 1981 | 6268546 |
| the development and evaluation of a solid-phase radioimmunoassay (ria) procedure for the determination of susceptibility to varicella. | the development of a sensitive solid-phase radioimmunoassay (ria) procedure for the detection of specific antibodies against varicella-zoster (vzv) is described. the test proved to be about 200 times more sensitive than complement fixation (cf) and far more efficient at detecting low levels of antibody in the sera of individuals with past history of varicella. it is suggested that this ria-vzv test would be suitable for distinguishing between individuals who are either immune or susceptible to v ... | 1981 | 6268649 |
| viral infections in pediatric burn patients. | bacterial and fungal infections are frequent complications of burns, but the frequency of viral infections has not been defined. in a retrospective survey of serum for viral antibodies in pediatric burn patients, 22% had fourfold increases in antibodies to cytomegalovirus (cmv); 8% had increases to herpes simplex virus and to epstein-barr virus; and 5% had increases to varicella-zoster virus. none of the patients had evidence of adenovirus or hepatitis b virus infection. on the basis of these ob ... | 1981 | 6267934 |
| antibody responses to varicella-zoster virus and the role of antibody in host defense. | antibody titers to varicella-zoster (vz) virus in persons aged 1-85 years were measured. through age 50, the percent of seropostitive individuals continued to rise. there was no fall in geometric mean titer with aging, and there may have been an increase in vz antibody titer in older persons. thus, a fall in vz antibody with increasing age does not seem likely to account for the increased incidence of zoster in the elderly. similarly, immunocompromised patients who are more likely to develop zos ... | 1981 | 6267940 |
| [infections due to herpes-varicella viruses in hodgkin's disease (author's transl)]. | the infections due to herpes-varicella viruses occurring in 191 patients with hodgkin's disease form the basis of this report. there were overall 41 episodes (26.7%) in 40 patients, distributed as follows: varicella in three cases, atypical herpes-varicella in two cases, and herpes zoster in 36 cases, the latter showing systemic spread in seven instances, one to the central nervous system (myelitis) and six to the skin. the mortality was 2.5% of all infections, and 33% of the varicella cases. mo ... | 1981 | 6264237 |
| thygeson's superficial punctate keratitis. | thygeson's superficial keratitis is a chronic disease of the cornea characterized by focal epithelial lesions. we studied 45 cases of thygeson's superficial punctate keratitis. twenty-eight were male and 17 were female patients. the disease had been active in our patients from one month to 24 years. the clinical findings, course, outcome, and response to therapy were studied. viral cultures and microscopic studies were performed on the corneal epithelial scrapings from ten cases. the average cou ... | 1981 | 6264365 |
| recovery of cell-free varicella virus from vero cells. | 1981 | 6264893 | |
| antisera to late cytomegalovirus nuclear antigens produced in cynomolgus monkeys. | 1981 | 6265560 | |
| production of monospecific antibodies to varicella zoster virus antigen in rabbits tolerant to human igg and immunized with antigen immunoprecipitated with human igg from zoster reconvalescent sera. | a method for production of antisera specific to a single antigen of a human infectious agent is described with varicella zoster virus (vzv) as a model. microisolation of immunochemically pure antigen contained in defined immunoprecipitates was achieved by crossed immunoelectrophoresis of a crude antigenic preparation (detergent solubilized, vzv infected cells) into agarose gel containing zoster reconvalescent immunoglobulin. immunization of rabbits made tolerant to human igg with immunoprecipita ... | 1981 | 6265561 |
| multifocal varicella-zoster virus leukoencephalitis temporally remote from herpes zoster. | two patients with cancer, one with hodgkin's disease and the other with a granulosa cell tumor of the ovary, developed a progressive, eventually fatal infection of the central nervous system exhibiting multifocal symptoms and signs. pathologically, gross abnormalities of the brain resembled those in progressive multifocal leukoencephalopathy (pml), with discrete and confluent plaque-like lesions concentrated in the white matter, particularly along the gray-white junction. microscopically, pathol ... | 1981 | 6261672 |
| enhancement of varicella-zoster virus replication in cultured human embryonic lung cells treated with the pesticide carbaryl. | in studies designed to determine the factors responsible for control of herpesvirus replicaton in an infected cell, we examined the interaction of varicella-zoster (vz) virus-infected human embryonic lung cells with the pesticide carbaryl. the replication of the cell-associated vz virus was enhanced 2- to 13-fold as compared to control cultures in sevin 4 oil-treated cultures and in cultures treated with the pesticide's active ingredient, carbaryl. the replication of vz virus in cultures teated ... | 1981 | 6261690 |
| rapid diagnosis of varicella-zoster virus infections by countercurrent immunoelectrophoresis. | a simple, accurate, and rapid method for laboratory diagnosis of varicella-zoster virus (vzv) infections using countercurrent immunoelectrophoresis (cie) is described. cie uses zoster convalescent-phase serum to detect vzv antigen in vesticular fluid. eighty-six patients were studied, 58 with vzv infections and 28 with vesicular or bullous rashes due to causes other than vzv infection. all patients with documented vzv infection had positive cie tests for vzv, and the controls were uniformly nega ... | 1981 | 6260875 |
| [an immunological study of herpes zoster patients iii--specific immunity (author's transl)]. | 1981 | 6260390 | |
| immune response after exposure to varicella zoster virus: characterization of virus-specific antibodies and their corresponding antigens. | fourteen varicella zoster virus antigens were identified that induce antibodies during primary and recurrent infections. these antigens, which included the major nucleocapsid polypeptide (molecular weight, 155,000) and three glycoproteins (molecular weights, 130,000, 88,000, and 60,000, respectively) plus a number of minor antigens, were identified in radioimmunoprecipitation assays, using [35s]methionine-labeled extracts of cells infected with varicella zoster virus and sera from patients with ... | 1981 | 6260665 |
| epstein-barr virus antibodies in children with atopic disease. | the prevalence and titers of antibodies to human herpetoviruses as well as rubella and mumps viruses were determined in 98 children with atopic diseases and in 55 nonatopic control children. the only significant difference between the two groups was found as regards epstein-barr virus (ebv) antibodies, which were found in higher titers in atopic children of all ages. increased levels of ebv antibodies were found both in children with asthma and atopic dermatitis. the frequency of seropositivity ... | 1981 | 6260689 |
| recurrent herpes zoster encephalitis. a complication of systemic lupus erythematosus. | a middle-aged woman had five discrete episodes of herpes zoster. the first attack consisted of uncomplicated herpes zoster ophthalmicus. the subsequent four episodes involved thoracic, cervical, and finally sacral dermatomes and were complicated by myelitis or encephalomyelitis. during the most recent attack, while she was receiving corticosteroids, varicella-zoster virus was cultured from the csf. in addition, the patient had strong evidence of systemic lupus erythematosus, with a history of ra ... | 1981 | 6257212 |
| decrease of the lymphoproliferative response to varicella-zoster virus antigen in the aged. | humoral antibodies and specific cellular immune reactions (proliferative immune response in the lymphocyte transformation test) to varicella-zoster virus antigen were measured in children, young adults, and elderly people. in children and young adults, the humoral varicella-zoster-specific antibodies and the virus-specific cellular immune response generally coincided. in the over-60 age group, however, a discrepancy was often observed between these parameters. ninety percent of the elderly subje ... | 1981 | 6163722 |
| inhibition of human herpesviruses by combination of acyclovir and human leukocyte interferon. | human leukocytes interferon in low concentrations (1 to 5 u/ml) enhanced the antiviral effect of acyclovir against herpes simplex virus, varicella-zoster virus, and cytomegalovirus grown in human fibroblasts. this occurred without additive inhibition of the division of human fibroblasts or proliferation of peripheral blood mononuclear cells. the combined antiviral effect was additive against clinical isolates of cytomegalovirus and was synergistic against clinical isolates of the other two virus ... | 1981 | 6166569 |
| enhancement of infectivity of cell-free varicella--zoster virus with diethylaminoethyl-dextran. | 1981 | 6163154 | |
| cellular and humoral immunity in hodgkin's disease. i patients in continuous long-term remission. | cell-mediated and humoral immunity to herpes simplex virus (hsv), cytomegalovirus (cmv) and varicella zoster virus (vzv) were examined in 37 patients with hodgkin's disease in continuous long term remission. this group had lower blast-transformation than a matched control group to all 3 antigens. patients originally showing b-symptoms had higher transformation to vzv than those with a-symptoms. patients treated with irradiation only had higher transformation than those treated with either chemot ... | 1981 | 6171864 |
| prevention of varicella zoster (vz) with poly(i) . poly(c) given during the incubation period. | poly i . poly c (poly i:c) was administered to six children with cancer who were exposed to varicella zoster (vz) and who were under active treatment to determine if this agent could prevent the development of overt varicella zoster (chickenpox). poly i:c was administered as a single injection during the incubation period, but beyond 72 hours, since zoster immunoglobulin (zig) is a proven effective agent in the first 72 hours. none of these patients had a prior history of vz and neither zig nor ... | 1981 | 6180079 |
| anticomplement immunofluorescence for the titration of antibody to varicella-zoster virus. | anticomplement immunofluorescence (acif) was tested for its use for the titration of antibody against varicella-zoster virus (vzv). acif antibody responses of patients with vzv infection were specific for vzv antigen and heterotypic responses to herpes simplex virus type-1 and cytomegalovirus antigens were not observed. comparative studies of acif, membrane immunofluorescence (mif) and indirect immunofluorescence (if), using acetone-fixed antigen, were carried out with nonimmune sera and convale ... | 1981 | 6166838 |
| comparison of the effects of arabinosyladenine, arabinosylhypoxanthine, and arabinosyladenine 5'-monophosphate against herpes simplex virus, varicella-zoster virus, and cytomegalovirus with their effects on cellular deoxyribonucleic acid synthesis. | in a single line of human foreskin fibroblasts, minimum inhibitory concentrations (mics) and the minimum intracellular virus inactivation concentrations (miics) of arabinosyladenine, arabinosylhypoxanthine, and arabinosyladenine 5'-monophosphate were assayed for a number of recent isolates of herpes simplex virus types 1 and 2 (hsv-1, hsv-2), varicella-zoster virus (vzv), and cytomegalovirus (cmv). (the term miic is used here to describe the selective qualitative intracellular inhibition of the ... | 1981 | 6166244 |
| acyclovir. | 1981 | 6116957 | |
| administration of live varicella vaccine to children wtih leukaemia. | live varicella vaccine was given to twenty-three children with lymphoreticular malignancies, twelve whose chemotherapy was complete and eleven who were still receiving therapy. seroconversion was observed in all twenty-three children, only one of whom lost his vaccine-induced antibody. eight of the children experienced thirteen exposures to varicella, including four continuing exposures in their households. varicella, manifested by the appearance of seven vesicular lesions, developed in only one ... | 1982 | 6127546 |
| human serum antibodies to varicella-zoster virus thymidine kinase. | the conditions required for the production of varicella-zoster virus (vsv)-induced deoxythymidine kinase (dtk) have been studied. extracts from vero cells harvested 62 h after vzv infection were found to contain vzv-induced dtk activity, with a minimal contribution from the cellular dtk activity. vzv dtk was shown to have a broad substrate specificity phosphorylating both deoxythymidine, deoxycytidine, and iododeoxyuridine. deoxythymidine triphosphate inhibition studies revealed an intermediate ... | 1982 | 6176544 |
| immunoprecipitable polypeptides specified by varicella-zoster virus. | 1982 | 6177095 | |
| serological reactivity of some monoclonal antibodies to varicella-zoster virus. | monoclonal antibodies to varicella-zoster virus, free from host cell reactivity, were produced by cell fusion technics. antibodies from four different clones showed diverse activities in neutralization immunofluorescence and complement fixation assays. the antibodies provide useful reagents for viral diagnosis and viral antigenic characterization. | 1982 | 6184037 |
| herpes simplex virus encephalitis: intrathecal synthesis of oligoclonal virus-specific igg, iga and igm antibodies. | paired specimens of serum and csf from seven patients with acute herpes simplex virus encephalitis were examined during the acute illness or the convalescent stage or during both stages. imprint immunofixation analyses of viral antibodies separated by agarose electrophoresis and by electrofocusing disclosed intrathecal production of herpes simplex virus igg antibodies in all seven patients, and of iga and igm antibodies in six and three of six patients, respectively. intrathecal production of he ... | 1982 | 6184456 |
| serum antibody profile against herpesviruses in renal transplant recipients. | forty-eight renal allograft recipients who had received a kidney graft 2 months to 8 years previously, were followed for the presence of serum antibody against cytomegalovirus (cmv), epstein-barr virus (ebv), herpes simplex virus (hsv), and varicella-zoster virus (vzv). these investigations were performed over a 6 months period and in at least two serum samples from each patient, obtained at intervals of 2-3 months. the presence of serological signs of recent or active infection were observed in ... | 1982 | 6100358 |
| immune responses to varicella-zoster in the aged. | skin test reactivity and in vitro lymphocyte stimulation responses to varicella-zoster (vz) were examined in a large normal population ranging in age from 6 months to 93 years. warning of cellular immunity, as examined by skin delayed hypersensitivity, began at age 40 years. skin test responses to phytohemagglutinin, however, remained positive into the eighth decade of life. in vitro lymphocyte stimulation responses to vz were usually positive (stimulation index greater than or equal to 2.5) unt ... | 1982 | 6277260 |
| the production of varicella zoster virus antiserum in laboratory animals. brief report. | hyperimmune anti-varicella zoster virus (vzv) antisera were prepared in balb/c mice, lewis rats and new zealand rabbits by subcutaneous inoculations of purified vz virions suspended in freund's adjuvant. vzv antibodies were demonstrated both by an enzyme-linked immunosorbent assay (elisa) and by indirect immunofluorescence (if). vzv could not be detected in organs of any inoculated animals by if or by cocultivation of tissue fragments from infected animals with human diploid fibroblasts. | 1982 | 6299237 |
| deoxythymidine kinases in varicella-zoster virus infected and biochemically transformed cells. | deoxythymidine kinase (tk) activity induced in varicella-zoster virus (vzv)-infected human embryonic fibroblast (hef) cells was immunologically distinguishable from that in non infected hef cells and also from that in herpes simplex virus type 1 (hsv-1) infected hef cells. the tks in vzv-biochemically transformed cells were immunologically the same as that induced in vzv-infected human cells and immunologically different from that in ltk- cells or in hsv-biochemically transformed cells. one peak ... | 1982 | 6299267 |
| selection and preliminary characterization of acyclovir-resistant mutants of varicella zoster virus. | a series of acyclovir-resistant mutants of varicella zoster virus (vzv) were selected in vitro by serial passage of vzv-infected human fibroblasts in increasing drug concentrations, or by continuous exposure of cultures infected at high multiplicity to 100 microm acyclovir. the in vitro susceptibility of these mutants to several antiherpetic agents was measured by the plaque-reduction assay. the capacity of extracts of cells infected with these mutants to phosphorylate acyclovir was examined and ... | 1982 | 6285728 |
| interview with philip a. brunell: contagion and varicella-zoster virus. | 1982 | 6296801 | |
| [application of enzyme-linked protein a to elisa for detection of virus specific antibodies]. | 1982 | 6298319 | |
| simian varicella virus (delta herpesvirus) infection of patas monkeys leading to pneumonia and encephalitis. | 1982 | 6278510 | |
| the use of herpes virus induced dtk as a marker for serological and direct identification of herpes virus infection in man. | this report summarizes the essential features of a sensitive deoxythymidine kinase (dtk) assay, which can be used for the diagnosis of herpes virus infections. a type specific antibody response towards the different herpes virus dtk isozymes, the herpes simplex virus (hsv) type 1, type 2, and varicella zoster virus (vzv), was found in human sera. the occurrence of dtk antibody in relation to complement fixing (cf) antibody and the state of infection, was found to differ between hsv and vzv. the ... | 1982 | 6299830 |
| development of sensitive and enzyme-linked immunoassays for herpesvirus antigens and some applications. | sensitive enzyme-linked immunoassays for herpes simplex virus (hsv), cytomegalovirus (cmv) and varicella-zoster virus (vzv) were developed. both a sandwich technique, using antiviral antibodies from two species to detect the antigen, and an inhibition assay where the sample antigen was incubated with one antiserum, could be used. around 4-50 ng of viral antigens (measured as protein content) could be detected. the elisa inhibition technique using type-specific antisera could differentiate betwee ... | 1982 | 6299833 |
| effect of acyclovir combined with other antiherpetic agents on varicella zoster virus in vitro. | the sensitivity of varicella zoster virus (vzv) strain ellen to acyclovir in combination with other antiherpetic agents in vitro has been examined by the plaque-reduction and infectious center assay methods. (e)-5-(2-bromovinyl)-2'-deoxyuridine (bvdu), trifluorothymidine (tft), or 5-iodo-2'-deoxyuridine (idurd) produced, in general, additive antiviral activity when examined by either assay method. acyclovir in combination with phosphonoacetate (paa) resulted in additive effects as measured by th ... | 1982 | 6285733 |
| molecular cloning and physical mapping of varicella-zoster virus dna. | varicella-zoster virus (vzv) dna was cleaved with restriction endonuclease ecori, and most of the resulting fragments were successfully cloned in the phage vector lambda gtwes . lambda b. double digestions of cloned fragments with ecori and bamhi and hybridizations to blot-transferred bamhi digests of vzv dna were used to construct a physical map of the genome. the molecular termini of the dna were identified by restriction enzyme analysis after exonuclease iii digestion. the data indicate that ... | 1982 | 6280178 |
| study of persistence of maternal antibodies to varicella-zoster virus by indirect haemagglutination, with result control by radioimmunoassay. | the persistence of maternal antibody against varicella-zoster virus was studied by the method of indirect haemagglutination (ih) and a control of the results was performed by radioimmunoassay (ria). the findings were analysed with reference to the constant half-life of passively acquired igg and the titre range and frequency of antibodies in 220 persons of fertile age representative of the normal population. statistical analysis of expected and the experimentally obtained data was performed. amo ... | 1982 | 6282961 |
| activation and antiviral effect of acyclovir in cells infected with a varicella-like simian virus. | acyclovir inhibited the replication of a varicella-like simian virus (dhv-1) in cell culture (vero cells) with an ed50 of 38 +/- 2 microm. the activation of acyclovir in this cell culture system was compared with that in the cell system with human varicella zoster virus (vzv). extracts of cells infected with dhv-1 catalyzed the phosphorylation of acyclovir. the phosphorylation was inhibited by dthd, suggesting the catalyst was a dthd kinase. electrophoresis of cytosol fractions on polyacrylamide ... | 1982 | 6285734 |
| herpes zoster in childhood. | 1982 | 6283515 | |
| [immunological response of patients with herpes zoster (author's transl)]. | 1982 | 6286440 | |
| persistent varicella-zoster virus infection in a human rhabdomyosarcoma cell line and recovery of a plaque variant. | varicella-zoster virus (vzv) has been found to persistently infect the human rhabdomyosarcoma cell line a204. infectious center assays and fluorescent antibody staining demonstrated continuous production of infectious vzv and viral antigen. the level of infection determined by fluorescent antibody staining was variable, and usually only a small percentage of the cells were capable of producing plaques in permissive fibroblasts. the extent of infection was similar in cell cultures passaged at spl ... | 1982 | 6286495 |
| [laboratory diagnosis for varicella-zoster virus infection--detection of viral antigens in vesicular fluid and susceptibility test for antiherpes drugs (author's transl)]. | 1982 | 6283211 | |
| experimental infection and immune response of guinea pigs with varicella-zoster virus. | an immune response (fluorescent antibody to membrane antigen) was detected in guinea pigs inoculated with varicella-zoster virus (vzv) adapted to guinea pig embryonic cells, including the oka vaccine strain, even when inoculation was by an external route, i.e., nasal or corneal. live or uv-inactivated virus having the same virus titer before irradiation was administered to guinea pigs by the corneal route, and antibody induction was detected only with live virus. the transmission of vzv from inf ... | 1982 | 6288560 |
| [effect of ph and methylcellulose on establishment of "in vitro" infection with cell-free varicella-zoster virus]. | 1982 | 6306922 |