Publications

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generation and characterization of suncus murinus intestinal organoid: a useful tool for studying motilin secretion.motilin, a 22-amino-acid peptide produced in the upper small intestine, induces strong gastric contraction in fasted state. in many rodents, motilin and its cognate receptors exist as pseudogenes, which has delayed motilin research in the past decades. recently, the house musk shrew (suncus murinus) was developed as a useful model for studying motilin and gastrointestinal motility. however, due to a lack of motilin-producing cell lines and difficulties in culturing small intestinal cells, the re ...201931293061
molecular cloning and analysis of suncus murinus group iia secretary phospholipase a2 expression.the intestinal epithelial monolayer forms a mucosal barrier between the gut microbes and the host tissue. the mucosal barrier is composed of mucins and antimicrobial peptides and proteins (amps). several animal studies have reported that paneth cells, which occupy the base of intestinal crypts, play an important role in the intestinal innate immunity by producing amps, such as lysozyme, reg3 lectins, α-defensins, and group iia secretory phospholipase a2 (giia spla2). the house musk shrew (suncus ...201931278953
characteristics of muscle fiber-type distribution in moles.moles are a strictly fossorial soricomorpha species and possess a suite of specialized adaptations to subterranean life. however, the contractile function of skeletal muscles in moles remains unclear. we compared muscle fiber-type distribution in two mole species (the large japanese mole and lesser japanese mole) with that in four other soricomorpha species that are semi-fossorial, terrestrial, or semi-aquatic (the japanese shrew-mole, house shrew, japanese white-toothed shrew, and japanese wate ...201930376699
novel hepacivirus in asian house shrew, china. 201930701456
identification and characterization of an antimicrobial peptide, lysozyme, from suncus murinus.lysozyme is one of the most prominent antimicrobial peptides and has been identified from many mammalian species. however, this enzyme has not been studied in the order insectivora, which includes the most primitive placental mammals. here, we done the lysozyme cdna from suncus murinus (referred to as suncus, its laboratory name) and compare the predicted amino acid sequence to those from other mammalian species. quantitative pcr analysis revealed a relatively higher expression of this gene in t ...201930680460
the distribution of nerves supplying the testis, epididymis and accessory sex glands of suncus murinus.chronic testicular pain remains an important challenge for urologists. investigation of the innervation of male gonads thus becomes essential for deepening our understanding of their regulatory roles in male reproductive physiology and pathophysiology. studies of testicular innervation are mainly limited to the intratesticular peptidergic nerves of the testis by immunohistochemical and acetylcholinesterase histochemical investigations in some animals. little is known about the detailed, overall ...201930206773
detection and phylogenetic analysis of porcine bocaviruses carried by murine rodents and house shrews in china.bocaparvovirus infections of humans and both wild and domestic animals have been widely reported around the world. in this study, we detected and genetically characterized porcine bocavirus (pbov) carried by murine rodents (rattus norvegicus, rattus tanezumi, and rattus losea) and house shrews (suncus murinus) in china. between may 2015 and may 2017, 496 murine rodents and 23 house shrews were captured in four chinese provinces. nested polymerase chain reaction was used to investigate the preval ...201930179306
hematological and biochemical reference values of asian house shrews (suncus murinus) in bangladesh.determining reference values for hematological and biochemical parameters of asian house shrew (suncus murinus) is important for wildlife research to protect human health in surrounding communities. this study aimed to establish the reference values for selected hematology and serum clinical chemistry analyses that may contribute to research on shrew in future.201931749590
molecular identification, characterization, and structure analysis of house musk shrew (suncus murinus) leptin.house musk shrew (suncus murinus), a small experimental animal with low body fat, may be a possible model for human lipodystrophy. leptin is an adipocyte-derived hormone thought to have an important role in the pathophysiology of lipodystrophy. the objectives of this study were to clarify the structure and distribution of suncus leptin.201931453164
methicillin-resistant staphylococcus aureus among urban rodents, house shrews, and patients in guangzhou, southern china.the transmission of methicillin-resistant staphylococcus aureus (mrsa) between humans and animals has been identified in a number of countries. in this study, mrsa in urban rodents and shrews in a community was investigated. further, comparisons of mrsa isolates from rodents, shrews, and humans were conducted to evaluate the relationships of these isolates from different origins.201931345215
comparison of the gut microbiotas of laboratory and wild asian house shrews (suncus murinus) based on cloned 16s rrna sequences.the asian house shrew, suncus murinus, is an insectivore (eulipotyphla, mammalia) and an important laboratory animal for life-science studies. the gastrointestinal tract of suncus is simple: the length of the entire intestine is very short relative to body size, the large intestine is quite short, and there are no fermentative chambers such as the forestomach or cecum. these features imply that suncus has a different nutritional physiology from those of humans and mice, but little is known about ...201931217361
detection of hepatitis b virus-like nucleotide sequences in liver samples from murine rodents and asian house shrews.in recent years, hepatitis b virus (hbv) has been detected in some species of animals. in this study, we found hbv-like nucleotide sequences in murine rodents and asian house shrews (suncus murinus) collected in china. a total of 801 animals were trapped. we found that 0.48% (3/624) of the murine rodents and 1.69% (3/177) of asian house shrews were positive for hbv-like dna. detection of hbv-like dna in brown rats (rattus norvegicus), rice-field rat (rattus losea), and asian house shrews indicat ...201931216240
use of a microelectrode array to record extracellular pacemaker potentials from the gastrointestinal tracts of the icr mouse and house musk shrew (suncus murinus).the rhythmic contraction and relaxation of smooth muscles in the gastrointestinal (gi) tract is governed by pacemaker electrical potentials, also termed slow waves, which are calcium currents generated by interstitial cells of cajal (iccs). malfunction of pacemaker rhythms contributes to a number of clinically challenging gastrointestinal motility disorders.201931125825
the brain-penetrating, orally bioavailable, ghrelin receptor agonist hm01 ameliorates motion-induced emesis in suncus murinus (house musk shrew).hm01, a novel, orally bioavailable, brain-penetrating agonist of ghrelin receptors, ameliorates emesis in suncus murinus. this study compared hm01's activity against motion sickness with that of the less brain-penetrating ghrelin receptor agonist, hm02.202031722444
characterization of a novel rat hepatitis e virus isolated from an asian musk shrew (suncus murinus).the asian musk shrew (shrew) is a new reservoir of a rat hepatitis e virus (hev) that has been classified into genotype hev-c1 in the species orthohepevirus c. however, there is no information regarding classification of the new rat hev based on the entire genome sequences, and it remains unclear whether rat hev transmits from shrews to humans. we herein inoculated nude rats (long-evans rnu/rnu) with a serum sample from a shrew trapped in china, which was positive for rat hev rna, to isolate and ...202032630296
corrination of a glp-1 receptor agonist for glycemic control without emesis.glucagon-like peptide-1 receptor (glp-1r) agonists used to treat type 2 diabetes mellitus often produce nausea, vomiting, and in some patients, undesired anorexia. notably, these behavioral effects are caused by direct central glp-1r activation. herein, we describe the creation of a glp-1r agonist conjugate with modified brain penetrance that enhances glp-1r-mediated glycemic control without inducing vomiting. covalent attachment of the glp-1r agonist exendin-4 (ex4) to dicyanocobinamide (cbi), ...202032553160
evaluation of repeated or acute treatment with cannabidiol (cbd), cannabidiolic acid (cbda) or cbda methyl ester (hu-580) on nausea and/or vomiting in rats and shrews.when acutely administered intraperitoneally, the non-psychoactive cannabinoid cannabidiol (cbd), its acidic precursor cannabidiolic acid (cbda) and a stable methyl ester of cbda (hu-580) reduce lithium chloride (licl)-induced conditioned gaping in male rats (a selective preclinical model of acute nausea) via activation of the serotonin 1a (5-ht1a) receptor.202032488349
a second-generation glucagon-like peptide-1 receptor agonist mitigates vomiting and anorexia while retaining glucoregulatory potency in lean diabetic and emetic mammalian models.to develop a conjugate of vitamin b12 bound to the glucagon-like peptide-1 receptor (glp-1r) agonist exendin-4 (ex4) that shows reduced penetrance into the central nervous system while maintaining peripheral glucoregulatory function.202032410372
evidence of natural infection of orientia tsutsugamushi in vectors and animal hosts - risk of scrub typhus transmission to humans in puducherry, south india.scrub typhus infection is endemic in india and reported to be the major cause for acute encephalitis syndrome (aes) in humans. periodic occurrence of scrub typhus cases and presence of pathogen in rodents were also reported in areas with human cases of scrub typhus in puducherry.202032189679
invasive plants facilitated by socioeconomic change harbor vectors of scrub typhus and spotted fever.ecological determinants of most emerging vector-borne diseases are understudied, particularly for neglected tropical disease. moreover, although socioeconomic impacts can have significant downstream effects on human risks to vector-borne diseases via a change in land cover, particularly facilitating the invasion of exotic plants, related studies remains very scarce. scrub typhus and spotted fever are neglected diseases emerging around the globe and are transmitted by chigger mites and ticks infe ...202031961870
gdf15 induces anorexia through nausea and emesis.growth differentiation factor 15 (gdf15) is a cytokine that reduces food intake through activation of hindbrain gfral-ret receptors and has become a keen target of interest for anti-obesity therapies. elevated endogenous gdf15 is associated with energy balance disturbances, cancer progression, chemotherapy-induced anorexia, and morning sickness. we hypothesized that gdf15 causes emesis and that its anorectic effects are related to this function. here, we examined feeding and emesis and/or emetic ...202031928886
pcr-based screening and phylogenetic analysis of rat pegivirus (rpgv) carried by rodents in china.rodent-borne pegiviruses were initially identified in serum samples from desert wood-rats in 2013, and subsequently in serum samples from commensal rats in 2014. however, the prevalence and phylogenetic characteristics of rodent pegiviruses in china are poorly understood. in this study, we screened serum samples collected from wild rats in southern china between 2015 and 2016 for the presence of rat pegivirus (rpgv) by pcr. among the 314 serum samples from murine rodents (rattus norvegicus, ratt ...202032713889
genetic diversity and phylogeography of thottapalayam thottimvirus (hantaviridae) in asian house shrew (suncus murinus) in eurasia.murid and cricetid rodents were previously believed to be the principal reservoir hosts of hantaviruses. recently, however, multiple newfound hantaviruses have been discovered in shrews, moles, and bats, suggesting a complex evolutionary history. little is known about the genetic diversity and geographic distribution of the prototype shrew-borne hantavirus, thottapalayam thottimvirus (tpmv), carried by the asian house shrew (suncus murinus), which is widespread in asia, africa, and the middle ea ...202032974220
glp-1 receptors are involved in the glp-1 (7-36) amide-induced modulation of glucose homoeostasis, emesis and feeding in suncus murinus (house musk shrew).glp-1 receptor agonists are used for the treatment of type 2 diabetes but they may reduce appetite and cause nausea and emesis. we investigated if glp-1 (7-36) amide can modulate glucose homoeostasis, emesis and feeding via an exendin (9-39)-sensitive mechanism in suncus murinus. the effect of glp-1 (7-36) amide on glucose homeostasis was examined using an intraperitoneal glucose tolerance test. in conscious fasted animals, food and water consumption and behavior were measured for 1 h following ...202032871177
seroprevalence of wenzhou virus in china.wenzhou virus (wenv) was first identified in rodents and asian house shrews in wenzhou, zhejiang province, china. however, little is known about the prevalence of wenv infections in humans in china. to determine the threat that wenv may pose to humans, we determine the seroprevalence of wenv in healthy individuals in china in this study. cross-reactivities of nucleoprotein (np) were detected between lymphocytic choriomeningitis virus (lcmv) and wenv using western blot and elisa assy. the prevale ...202032838285
composition of gut and oropharynx bacterial communities in rattus norvegicus and suncus murinus in china.rattus norvegicus and suncus murinus are important reservoirs of zoonotic bacterial diseases. an understanding of the composition of gut and oropharynx bacteria in these animals is important for monitoring and preventing such diseases. we therefore examined gut and oropharynx bacterial composition in these animals in china.202033129337
helminth fauna of small mammals from public parks and urban areas in bangkok metropolitan with emphasis on community ecology of infection in synanthropic rodents.in 2018, extensive field studies of diversity and prevalence of helminth infection in synanthropic rodents and non-rodent small mammals from public parks and citified areas in the bangkok metropolitan were conducted. rattus rattus complex was the dominant small mammal in public parks. of the 197 animals, 147 individuals were infected with one or more species of helminths, yielding an infection prevalence of 74.6%. twenty-five species of helminths were recovered during necropsy. pterygodermatites ...202033001253
detection of virus-related sequences associated with potential etiologies of hepatitis in liver tissue samples from rats, mice, shrews, and bats.hepatitis is a major global health concern. however, the etiology of 10-20% hepatitis cases remains unclear. some hepatitis-associated viruses, like the hepatitis e virus, are zoonotic pathogens. rats, shrews, and bats are reservoirs for many zoonotic pathogens. therefore, understanding the virome in the liver of these animals is important for the investigation of the etiologies of hepatitis and monitoring the emerging zoonotic viruses. in this study, viral metagenomics and pcr methods were used ...202134177835
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