Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| pharmacologic studies of clofazimine. | 1974 | 4611255 | |
| further experience with the rapid bactericidal effect of rifampin on mycobacterium leprae. | 1974 | 4611256 | |
| immune response to mycobacterium leprae: plaque-forming cells in mice. | intravenous immunization with a cell extract of mycobacterium leprae produced a primary immune response of considerable magnitude, followed by an equally large response after secondary stimulation, as measured by assay of plaque-forming cells (pfc). infection with m. leprae or immunization with cell extract by the footpad route produced a lower level of response than that seen in the intravenous group. identical patterns of response, although not of the same magnitude, were observed after both p ... | 1974 | 4611925 |
| effect of sodium hydroxide and trypsin on the viability of mycobacterium leprae. | 1974 | 4611983 | |
| electronmicroscopic demonstration of myco leprae in axons. | 1974 | 4612273 | |
| immunological problems in leprosy research: 1. | 1974 | 4612274 | |
| drug resistance in leprosy. | 1974 | 4612275 | |
| delayed hypersensitivity in vitro to an acid fast mycobacterium cultivated from human lepromatous leprosy. | 1974 | 4613642 | |
| the pathology of a radial nerve biopsy in leprosy: light and electron microscopy. | 1974 | 4613809 | |
| quantitative and qualitative studies of the local cellular exudative response in leprosy. | 1974 | 4613829 | |
| ten years of dapsone in lepromatous leprosy: clinical, bacteriological and histological assessment and the finding of viable leprosy bacilli. | 1974 | 4613977 | |
| rapid identification tests for mycobacterium leprae: a clarification. | 1974 | 4613979 | |
| pathologic changes in the soft palate in lepromatous leprosy. an evaluation of ten patients. | 1974 | 4614162 | |
| cultivation of human peripheral blood monocytes in vitro. | 1974 | 4616011 | |
| immunology of leprosy. | 1974 | 4616227 | |
| some practical problems of the epidemiology of leprosy in the indian context. | 1974 | 4616262 | |
| pathobiological relationships between mycobacterium leprae and its primitive host. | newborn snakes were injected with 10(2)-10(4) live or heated mycobacterium leprae. death occurred in 5-6 weeks. on autopsy, the snakes injected with live microorganisms showed pathological changes and numerous acid-fast bacteria were found in some organs. material was also transferred from an experimentally infected snake to a group of normal newborn snakes, causing their death in 3 weeks. extracts in phosphate-buffered saline, prepared from the tissues of infected snakes, were found to react wi ... | 1974 | 4616779 |
| growing points in leprosy research. i. the armadillo as an experimental model for the study of human leprosy. | 1974 | 4602615 | |
| growing points in leprosy research. 2. epidemiology. | 1974 | 4602616 | |
| the occurrence of mycobacterium leprae within axons of peripheral nerves. | 1974 | 4601761 | |
| mycolic acids from "noncultivable" mycobacteria. | chromatographic analysis, coupled to mass spectrometry with a high-resolution mass spectrometer, of materials isolated from skin lesions of patients with lepromatous leprosy allows the recognition of characteristic mycobacterial products, mycolic acids. this finding indicates that the "noncultivable" bacteria responsible for leprosy are mycobacteria. | 1974 | 4601900 |
| the result of inoculation of mycobacterium leprae in the goldfish (carassius auratus). | 1974 | 4599823 | |
| uptake of radioactive dopa by m. leprae. | 1974 | 4600624 | |
| trophic skin ulceration of leprosy: skin and serum zinc concentrations. | skin and serum zinc measurements have been made in patients with leprosy with and without trophic skin ulceration and in several other groups. serum zinc concentrations were decreased in leprosy irrespective of the presence or absence of skin ulceration. serum zinc concentrations in leprosy were also unrelated to smears positive for mycobacterium leprae and to the clinical type of leprosy. since a decrease of the serum zinc was also found in patients with dermatitis herpetiformis and pulmonary t ... | 1974 | 4601207 |
| skin, dartos, and nerve biopsies as aids to diagnosis in leprosy. | 1974 | 4598943 | |
| development of an established cell line derived from dasypus novemcinctus (armadillo), a laboratory animal susceptible to infection by mycobacterium leprae. | 1974 | 4599002 | |
| editorial: prevention of leprosy. | 1974 | 4598138 | |
| intra-axonal bacilli in lepromatous leprosy. a light and electron microscopic study. | 1974 | 4597056 | |
| the rate of bactericidal action of rifampin on mycobacterium leprae in the mouse footpad. | 1974 | 4597278 | |
| [leprosy]. | 1974 | 4595692 | |
| impact of cool temperatures on transformation of human and armadilio lymphocytes (dasypus novemcinctus, linn.) as related to leprosy. | 1974 | 4596004 | |
| the nasal discharge in leprosy. | 1974 | 4596613 | |
| genitourinary leprosy. | 1974 | 4596831 | |
| leprosy: confirmation in the armadillo. | bacteria isolated from lesions of lepromatoid leprosy in the armadillo were studied in comparison with mycobacterium leprae isolated directly from human lepromatous leprosy lesions. three methods were used to show that the bacteria from the lesions of the armadillo were identical to those of the human lesions: (i) extraction of the bacteria with pyridine and subsequent staining with various techniques, (ii) the competence in clearing bacilli (ccb) test, and (iii) the mitsuda test. | 1974 | 4133762 |
| intracellular growth of an obligatory parasite mycobacterium leprae. host bacterial interactions. | 1974 | 4135832 | |
| electron microscope study of erythema nodosum leprosum. | 1974 | 4137644 | |
| fluorescent staining for mycobacterium leprae in tissue sections. comparison with fite-faraco procedure. | 1974 | 4137671 | |
| morphological changes of mycobacterium leprae grown in mouse foot pads. | 1974 | 4140172 | |
| acid mucopolysaccharide metabolism in leprosy. 1. storage of hyaluronic acid and its possible significance in the pathogenesis of leprosy. | a histochemical analysis of 102 skin biopsies from a variety of leprosy types revealed the persistent presence of hyaluronic acid in lepra cells of lepromas. in contrast, the hyaluronic acid content of tuberculoid epithelioid cells showed a minimum amount of hyaluronic acid and hyaluronic acid tended to disappear from these granulomas as they aged. the macrophages of dimorphous leprosy occupied an intermediate position with respect to hyaluronic acid content and distribution, resembling the tube ... | 1974 | 4142476 |
| [effect of a uniform magnetic field on leukocytes. study of the leukocyte migration test in lepers]. | 1974 | 4142862 | |
| [microbiology of leprosy. behavior and staining affinities of hansen's bacillus in leprous lesions]. | 1974 | 4143388 | |
| letter: thalidomine neuropathy and leprous neuritis. | 1974 | 4129733 | |
| letter: culturing mycobacterium leprae in the dark. | 1974 | 4129740 | |
| tenth international leprosy congress bergen, 1973. reports of committees. | 1974 | 4152479 | |
| [100 years of mycobacterium leprae]. | 1974 | 4154579 | |
| the growth of mycobacterium leprae in snakes. | 1974 | 4207054 | |
| bcg antibody profiles in tuberculoid and lepromatous leprosy. | in sera from 12 patients with polar tuberculoid leprosy, 12 with subpolar tuberculoid leprosy, and 16 with lepromatous leprosy were demonstrated a total number of 125 anti-bcg precipitins by means of crossed immunoelectrophoresis with intermediate gel. up to 14 different precipitins were found in individual sera, and the complexity in antibody response was higher than previously realized. the specificity of 69% of the antibodies was defined, and these antibodies were titrated in three arbitrary ... | 1974 | 4207518 |
| detection of biological false positive syphilis serum reactions. | 1974 | 4209642 | |
| potential antileprotic agents. 3. inhibition of mycobacterial dihydrofolic reductase by 2,4-diamino-5-methyl-6-alkylquinazolines. | 1974 | 4209923 | |
| [cross reactions in the serological diagnosis of chagas' disease and kala-azar including sera of tuberculous and leprous patients (author's transl)]. | 1974 | 4207936 | |
| the pathogenesis of the neuropathy in dimorphous leprosy: electron microscopic and cytochemical studies. | 1974 | 4366311 | |
| peripheral nerve involvement in leprosy: quantitative histologic aspects. | 1974 | 4374004 | |
| effect of inorganic and organic substances containing sulfur or nitrogen and of vitamins on the growth of mycobacterium leprae. | 1974 | 4278072 | |
| acid mucopolysaccharide metabolism in leprosy. 2. subcellular localization of hyaluronic acid and beta-glucuronidase in leprous infiltrates suggestive of a host-mycobacterium leprae metabolic relationship. | electron- and light microscopic analyses were conducted on leprosy skin biopsies relative to the origin of hyaluronic acid, which has previously been observed to be distributed inversely in ratio to the degree of cell- mediated immunity. the present study investigated the subcellular localization of hyaluronic acid and its degrading enzyme in various types of leprosy. hyaluronic acid in some lepromatous leprosy cases was shown to be accumulated in the limiting membranes of the phagosomes of lepr ... | 1974 | 4282081 |
| quantitative evaluation of the progress of intracellular infection in vitro: incorporation of 3h-thymidine into deoxyribonucleic acid by mycobacterium leprae in cultivated blood monocytes. | growth of intracellular parasites such as mycobacterium leprae in macrophages derived from human peripheral blood monocytes can be assessed by selective incorporation of [methyl-(3)h]thymidine into deoxyribonucleic acid of the bacterial cells. the radioactive precursor is not taken up by the host cells, and evidence has been presented for its incorporation into bacteria. the procedure is sensitive, reproducible, and highly quantitative. | 1974 | 4128631 |
| comparison of the modes of spread and the incidence of tuberculosis and leprosy. | 1974 | 4128836 | |
| a light and electron microscopic study of peripheral nerves in an armadillo with disseminated leprosy. | 1974 | 4617714 | |
| effects of the administration of b663 [g 30 320, lamprene, clofazimine (geigy)] on three groups of lepromatous and borderline of leprosy. | 1974 | 4617715 | |
| minimum inhibitory and bactericidal dosages of rifampici against mycobacterium leprae in the mouse foot pad: relationship to serum rifampicin concentrations. | 1974 | 4617716 | |
| controlled long-term therapy of leprosy with b663 (lamprene, clofazimine) compared with dds. | 1974 | 4617720 | |
| lepromin retesting as a factor of lepromin test positivation. | 1974 | 4617721 | |
| leprosy of the nose clinical reassessment. | 1974 | 4617723 | |
| letter: lepromin nomenclature. | 1974 | 4617726 | |
| [experimental transmission of m. leprae in the testis of mice, born from 131i-injected females (author's transl)]. | 1974 | 4618883 | |
| elimination of mycobacterium leprae subsequent to local in vivo activation of macrophages in lepromatous leprosy by other mycobacteria. | 1974 | 4619359 | |
| [tropism of mycobacterium leprae for the nevis cells]. | 1974 | 4619901 | |
| survival of mycobacterium leprae in newborn rat heart cell culture. | 1974 | 4620142 | |
| resistance to mycobacterium leprae in mice infected with toxoplasma gondii and besnoitia jellisoni. | mice chronically infected with the intracellular protozoan toxoplasma gondii or besnoitia jellisoni were resistant to footpad challenge with mycobacterium leprae. resistance was manifested by lower numbers of recoverable m. leprae in the footpads of protozoal-infected mice and was enhanced in toxoplasma-infected mice by a booster injection of toxoplasma antigen in the infected footpad. the results suggest a major role for the activated macrophage in the control of m. leprae infection. | 1974 | 16558091 |
| leukocyte antimicrobial function in patients with leprosy. | patients with lepromatous leprosy are unresponsive to lepromin skin-test material and possess defective lymphocyte function in vitro, including impaired mitogenesis in response to antigens of mycobacterium leprae. it has been claimed that their macrophages cannot digest m. leprae in vitro; such a defect could explain both lepromin nonreactivity and impaired lymphocyte function on the basis of failure of the afferent limb of the immune response (i.e., defective macrophage "processing" of m. lepra ... | 1974 | 11344550 |
| inhibition of multiplication of mycobacterium leprae by several antithyroid drugs. | multiplication of mycobacterium leprae in the mouse footpad was inhibited when mice were fed, mixed in their diet, 0.05 per cent methimazole, 0.066 per cent usp thyroid powder, methimazole plus thyroid powder, 0.15 per cent 5-n-heptyl-2-thioxo-4-thiazolidinone, 0.1 per cent propylthiouracil, and 0.1 per cent thambutosine for 154 days, beginning on the day of inoculation. all of the treatment regimens, except for the 2 containing thyroid powder, decreased the plasma concentrations of thyroxine an ... | 1975 | 48349 |
| sulphone resistance in leprosy. a review of one hundred proven clinical cases. | an account is given of the first hundred consecutive proven cases of sulphone resistance in leprosy, detected in malaysia between 1963 and 1974. proof of resistance was clinical in eighty patients and was obtained by drug-sensitivity testing in mice in ninety-six patients; 76 cases were proved both clinically and experimentally, and there was no discrepancy between the two methods. sulphone resistance was confined to patients with lepromatous-type leprosy--i.e., patients with a large bacterial p ... | 1975 | 49662 |
| letter: sulphone resistance in leprosy. | 1975 | 49763 | |
| innervation of muscle in leprosy with special reference to the muscle spindle. | the pattern of extrafusal and intrafusal innervation was studied in muscle biopsies from the flexor carpi ulnaris and biceps brachii muscles, which were clinically unimpaired. smudginess and enlargement of the motor end plates were the most definitely abnormal feature of the extrafusal innervation pattern; the intrafusal fibers, on the other hand, were either unremarkable or showed increased tortuosity, beading and in more extreme cases of grossly complicated intertwining pattern. bacilli were f ... | 1975 | 51013 |
| long-spacing collagen in skin biopsies from patients with lepromatous leprosy. | in the course fo evaluating the effect of different drugs on the morphology of mycobacterium leprae (edwards, draper & draper, 1972) and on the phagocytic cells containing these organisms (edwards, 1973), an unusual feature was observed in the dermal connective tissue of skin biopsies obtained from some of the patients. variable amounts of an extracellular, cross-striated osmiophilic material were present in the dermis. the purpose of this communication is to describe the banded substance observ ... | 1975 | 51648 |
| antigenic heterogeneity in patients with reactions in borderline leprosy. | fifteen patients with borderline leprosy who developed "reversal" reactions were studied from the inception of treatment. thirteen showed an appreciable increase in lymphocyte transformation (lt) when preparations of mycobacterium leprae were used as antigen. the lt responses to either "whole" or "sonicated" preparations of the bacillus in these 15 patients and in nine others also in reaction correlated with the clinical presentation. those with skin disease predominating in the reaction showed ... | 1975 | 53086 |
| mycobacterial antigens in antibody responses of leprosy patients. | a reference system for m. smegmatis antigens in crossed immunoelectrophoresis was used to study antibody activities in serum samples of 91 leprosy patients. all polar and borderline lepromatous patients were positive. mean numbers out of 14 m. smegmatis antigens involved were 4.3 and 3.5, respectively. precipitins against antigen no. 1 were seen in all lepromatous cases. antibodies against this antigen were detected in 50% of tuberculoid (polar, subpolar and borderline) cases. antibody activity ... | 1975 | 58844 |
| acid-fast properties and pyridine extraction of m. leprae. | the reportedly unique pyridine extractability of acid-fastness as an identifying characteristic for m. leprae was examined in the leprosy bacilli and in eight other strains of mycobacteria. the initial findings were, in general, in accord with previous reports except that m. smegmatis and m. phlei likewise demonstrated two hour pyridine extractability of acid-fastness. perhaps, more significantly, it was found that this characteristic in m. leprae is related to aged, probably nonviable bacilli. ... | 1975 | 58845 |
| lepromatous leprosy presenting with polyarthritis, myositis, and immune-complex glomerulonephritis. | a pakistani man aged 19 years was admitted to a rheumatological unit in the united kingdom with acute widespread polyarthritis accompanied by night sweats and fever. preliminary examination suggested reiter's disease, but further investigation showed acute glomerulonephritis with uraemia. the possibility of periarteritis nodosa, and the prominence of muscle tenderness in the legs, led to biopsies of striated muscle and skin, in both of which were changes typical of lepromatous leprosy, with many ... | 1975 | 126102 |
| an ultrastructural study of neuromuscular spindles in normal mice: with reference to mice and man infected with mycobacterium leprae. | mycobacterium leprae have been found within muscle spindles in mice, using electron microscopy, and in man, using light microscopy. their mode of entry clearly is important. it may be via capsular cells, capillaries or nerves. for this reason muscle spindles from normal mice were studied by electron microscopy with special reference to the capsule and the relationship of it with capillaries and nerves, as well as details of the intrafusal fibres and capsular space. a fenestrated capillary was fo ... | 1975 | 126981 |
| glomerular subepithelial deposits in lepromatous leprosy. | 1975 | 127533 | |
| leoprosy- clinical aspectos of nerve involvement. | leprosy is the cause of the commonest peripheral neuropathy. the predilection of mycobacterium leprae for nerve tissue accounts for the clinical features that are most dreaded and most characteristic of the disease. were it not for the progressive destruction of peripheral nerve trunks and the consequences of this, leprosy would largely remain a cutaneous condition of cosmetically unsightly hypopigmented or erythematous areas and aggregations of nodular thickenings. the neurologic damage in lepr ... | 1975 | 166794 |
| leprosy--histopathologic aspects of nerve involvement. | the most striking single feature of the clinical manifestations of leprosy is the very wide range of appearances shown by the skin lesions. these include the vague, hypopigmented macules of indeterminate leprosy; the large, sharply defined hypopigmented anaesthetic lesions of tuberculoid leprosy; the nodules and diffuse infiltration of lepromatous leprosy; and a wide range of plaques and annular lesions of the intermediate (borderline or dimorphous) types of disease. from superficial appearances ... | 1975 | 166795 |
| uptake of radioactive dopa by mycobacterium leprae in vitro. | our previous studies demonstrated that mycobacterium leprae contains a characteristic o-diphenoloxidase which converts a variety of phenolic compounds to quinones in vitro. this enzyme was not present in any other mycobacteria tested. the results reported here deal with the uptake and binding of radioactive dopa by m. leprae. the leprosy bacilli incubated with tritium-labelled dopa, readily took up the substrate. the binding of dopa by the bacilli was markedly inhibited by diethyldithiocarbamate ... | 1975 | 171542 |
| a histopathologic study of striated muscle biopsies in leprosy. | histopathologic changes in striated muscle biopsies in 50 cases of leprosy were studied; 40 being the lepromatous type and 10 the nonlepromatous type. all the biopsies were obtained from midportions of normal looking biceps muscles and paraffin embedded. sections cut in transverse and longitudinal planes were stained by hematoxylin and eosin, masson's trichrome, mallory's ptah, gomori's silver impregnation, and ziehl-neelsen's technic. lepromas, focal or confluent, in the endomysium, perimysium, ... | 1975 | 776842 |
| [sensitivity to dapsone, sulfamethoxypyridazine and ethionamide of mycobacterium leprae taken from patients treated by the drugs]. | suspensions of m. leprae from skin biopsies of patients treated with dapsone (dds) (four cases), sulfamethoxypyridazine (smp) (six cases), and ethionamide (eth) (seven cases), were inoculated into mouse foot pads and their sensitivity for the different drugs determined. two strains were dds resistant. resistance appeared after 13 and 14 years respectively after the start of treatment. five strains were isolated from patients treated with smp. relapses during sulfonamide treatment are considered ... | 1975 | 776843 |
| [cyto-morphological study of leprosy bacilli in the host cell (author's transl)]. | 1975 | 785134 | |
| [cyto-morphological study on m. leprae inoculated and grown in the mouse foot-pads (author's transl)]. | 1975 | 785135 | |
| the immune system of the nine-banded armadillo (dasypus novemcinctus, linn). | the armadillo is rapidly emerging as an animal for biomedical research. a morphological study of the immune system of the armadillo was undertaken to try to demonstrate a possible defect in the morphogenesis of the lymphoid organs that could account for their susceptibility to leprosy. blood from 20 domesticated adult armadillos revealed lymphocytes predominated among circulating leukocytes in the majority of animals, whereas in wild animals neutrophils predominated. necropsies revealed well-dev ... | 1975 | 1091181 |
| superinfection in mice previously infected with mycobacterium leprae. | previous studies of the protection of mice by prior infection with mycobacterium leprae in one hind footpad against challenge with m.leprae in the opposite hind footpad had produced conflicting results; therefore, the problem was restudied. in several experiments, balb/c mice were inoculated first in the right hind footpad with 5,000 m. leprae and then challenged in the left hind footpad with 5,000 m. leprae of the same strain at intervals after primary infection, at the same time that uninfecte ... | 1975 | 1091561 |
| further investigations on m. leprae. growth promotion and inhibition by organic substances and observations on antagonistic and syntergistic effects. | the multiplication of 2 strains of m. leprae on a medium containing a sonic extract (se), prepared from m. smegmatis, was promoted by cysteine, tryptophane and dimethylasulfoxide (dmso), while glutamic acid, glutamine and histidine exerted variable effects. the final effects of glutamic acid and glutamine were determined by the total concentration of both compounds together. the presence of cysteine and glutamic acid alone or together with dmso abolished all inhibitory effects. desferal did n ... | 1975 | 1092313 |
| immune responses to mycobacterium leprae in man. | 1975 | 1092818 | |
| the activity of chaulmoogra acids against mycobacterium leprae. | the activity of the crude sodium salts of the fatty acids of chaulmoogra oil and of hydnocarpic and chaulmoogric acids against mycobacterium leprae was studied in mouse footpad infection. multiplication of the organisms was inhibited when the salts were administered intraperitoneally and subcutaneously 3 times per week, and when chaulmoogric acid was administered intraperitoneally 5 times per week in half the equivalent dose. dihydrochaulmoogric acid was also active, whereas palmitic acid was no ... | 1975 | 1093460 |
| chemotherapy in leprosy. | 1975 | 1093982 | |
| hairless mice, human leprosy and thymus-derived-lymphocytes. | 1975 | 1095394 | |
| in vitro lymphocyte response to purified protein derivative, bcg and mycobacterium leprae in a population not exposed to leprosy. | lymphocytes from 14 bcg-vaccinated donors, seven tuberculin positive and seven tuberculin negative by skin testing, were stimulated in vitro with four mycobacterial antigens, purified protein derivative (ppd), ppd/bcg, whole bcg bacilli, and whole mycobacterium leprae and also with candida antigen and phytohemagglutinin. the response was measured by incorporation of (3)h-labeled thymidine. the response to ppd, ppd/bcg, and bcg was found to correlate with the result of skin testing with turbercul ... | 1975 | 1095479 |
| immunological studies on leprosy: separation and evaluation of the antigens of mycobacterium leprae. | chromatographically separated antigens of mycobacterium leprae were tested for their ability to elicit skin reactions in guinea-pigs sensitised with homologous and heterologous mycobacteria. of the three antigen-positive fractions obtained, one showed specific activity and the other two cross-reactivity, as indicated by studies of hypersensitivity and passive cutaneous anaphylaxis. the fraction exhibiting specificity contained only one antigen, which was protein in nature, whereas the other two ... | 1975 | 1095749 |
| [reproduction of mycobacterium leprae inoculated into rats fed with putrid cow meat]. | 1975 | 1096261 | |
| impairment of reactivity to lepromin by mycobacterial antigens related to, or identical with, mycobacterium leprae. | three hundred and twenty young children were injected with bacillus calmette-guerin (bcg) saline, or with one of the mycobacterial cytoplasmic antigens related with mycobacterium leprae. at an appropriate time thereafter they were tested for dermal hypersensitivity to the antigens and for reactions to lepromin. whereas all the antigens induced cell-mediated immunity, the incidence and intensity of late response to lepromin were significantly reduced in children preinjected with the cytoplasmic m ... | 1975 | 1097072 |
| leprosy of the upper respiratory tract. a clinical bacteriological, histopathological and histochemical study of twenty cases. | twenty cases clinically diagnosed as leprosy were thoroughly examined for e.n.t. lesions. these lesions were subjected to bacteriological, histopathological and histochemical studies. the results have been tabulated and discussed with special stress on some findings which are of help in diagnosing the disease. | 1975 | 1097553 |
| the testis in mice infected with mycobacterium leprae. | following inoculation either locally or intravenously with mycobact. leprae of human origin, the histopathology and bacteriology of the testis in experimental mice is described. normal mice, and mice rendered immunologically deficient by thymectomy and whole-body irradiation, were studied. attention is drawn to a heavy bacillation of the testis in mice from both groups. bacilli were found in and beneath the tunica albuginea, but mainly in interstitial cells and in macrophages surrounding the tub ... | 1975 | 1097612 |