Publications

acne.		1978	147953
[polymorphous juvenile acne (author's transl)].	many factors may be involved in the pathogenesis of acne, the most important of them lie in the sebaceous follicle, in disturbances of the cornification of the follicular channels and in the bacterial flora of the hair follicles. the latter consists of a yeast (pityrosporon ovale), coagulase-negative aerobic staphylococci and propionibacterium acnes. p. acnes is found in the depth of the follicle. it is of particular importance for the pathogenesis because it produces a lipase which releases fat ...	1978	148004
skin surface glycerol levels in acne vulgaris.	free glycerol would be expected from biochemical considerations to be an end product of lipolysis of sebum triglycerides. glycerol was measured in skin surface washings of acne vulgaris patients, in acne vulgaris patients treated for at least 3 mo with oral tetracycline and in control subjects. surface glycerol in untreated acne subjects was significantly less than that expected theoretically, whereas the amounts of such glycerol in treated acne patients and in control subjects closely approache ...	1978	148480
[porphyrinsynthesis of propionibacterium acnes in acne and seborrhea (author's transl)].	the porphyrin productions of p a.-strains, isolated on the one hand from inlfammatory acne lesions, on the other hand from sebaceous follicle filaments from 10 persons each were compared quantitatively and qualitatively, after the appropriate material had been pooled, with respect to the acne strains one could observe a somewhat increased porphyrin production as well as the discharging of a precentually greater portion of porphyrins to the surrounding material. when separated by tlc the acne mat ...	1978	148872
complement activation by corynebacterium acnes.		1978	148901
adjuvant chemotherapy or chemoimmunotherapy in the management of primary malignant melanoma of level iii, iv, or v.		1978	111323
[effect of corynebacterium parvum on the glycosidases in guinea pig alveolar macrophages. role of the way of introduction (author's transl)].		1978	111745
detection of alcohols and volatile fatty acids by head-space gas chromatography in identification of anaerobic bacteria.	a head-space gas chromatographic technique for the analysis of volatile bacterial metabolites is described. bacteroides fragilis, clostridium perfringens, and propionibacterium acnes, cultured in a glucose-containing peptone yeast extract medium, were studied. the head-space technique was compared with the injection of the complete liquid culture medium, and solvent extracts thereof, into the gas chromatograph. volatile fatty acids could be detected by all three methods, whereas alcohols produce ...	1978	203602
local microwave hyperthermia (43 degrees c) and stimulation of the macrophage and t-lymphocyte systems in treatment of guerin epithelioma in rats.		1978	146340
adjvant treatment of tongue and floor of the mouth cancers.	since january 1974, 95 patients with anterior tongue and floor of the mouth cancers were included in a randomized trial. after stratification according to staging and initial treatment, one-third of the patients received chemotherapy for 2 years (methotrexate 400 mg followed by citrovorum factor 100 mg + bleomycin 60 mg/week, during the first 15 weeks), one-third of the patients received immunotherapy with weekly c. parvum injections during 2 years, while the remaining third did not receive any ...	1978	88754
[immunotherapy today. ii. immunostimulating therapy].		1978	93770
[gram-positive bacteria as adjuvants (author's transl)].	gram-positive bacteria or their constituents influence the immune response in various ways. for instance: listeria monocytogenes cellwall fraction acts as b-cell mitogen, in this way enhancing a humoral immune response. corynebacterium parvum acts as a macrophage stimulant evoking maximum macrophage activation. bcg, among other things, leads to an enhancement of a t-cell response to unrelated antigens. the hypothetical therapeutic consequences are discussed.	1978	96006
protection against chemotherapy toxicity by iv hyperalimentation.	a prospective randomized trial was conducted comparing the addition of iv hyperalimentation (ivh) to corynebacterium parvum, isophosphamide, and adriamycin (cia) chemoimmunotherapy in 26 patients with extensive squamous cell lung cancer. thirteen patients were entered in each treatment arm of the study and ivh was administered before and after the first course of cia for a total of 31 days. the major dose-limiting toxic effect of cia was leukopenia. less myelosuppression was observed for the pat ...	1978	99235
prostaglandin synthesis in spleen cell cultures of mice injected with corynebacterium parvum.		1978	102430
[action of corynebacterium parvum on the activity of glycosidases and proteases of peritoneal macrophages in the mice].	glycosidase and peptidase of non-treated mouse peritoneal macrophages were characterized. the enzymatic activities of corynebacterium parvum stimulated mouse macrophages were compared to those of macrophages obtained from non-treated animals. all the enzymatic activities, but beta-c-galactosidase, were higher in stimulated mouse macrophages.	1978	102445
pharmacologic factors and manipulation of immunity systemic adjuvants in cancer therapy.	because of the experimental and clinical studies which have been extensively conducted with bacillus calmette-guérin (bcg) as a systemic adjuvant in cancer immunotherapy, we have analyzed the main factors and conditions which determine its beneficial action and have underlined some of these (eg, the dose factor which controls the amplification of suppressor cells which is probably responsible for failures and even the possible tumor-enhancing effect of immunotherapy). knowing those factors and c ...	1978	103616
aerobic and anaerobic bacteriology of acute otitis media in children.	tympanocentesis and aerobic and anaerobic cultivation of the middle-ear fluid obtained was performed through one or both tympanic membranes of 62 children with acute otitis media. aerobic bacteria alone, predominantely pneumococcus and hemophilus influenzae, were isolated from 57% of patients; anaerobic organisms alone, most commonly propionibacterium acnes and peptococcus, from 15%. thirteen percent yielded mixtures of aerobes and anaerobes, and several had multiple aerobic or anaerobic agents. ...	1978	22590
resistance to marek's disease. effect of corynebacterium parvum and marek's tumor cell vaccines on tumorigenesis in chickens.	a study of nonspecific stimulation of the avian immune system with corynebacterium parvum and specific stimulation with marek's tumor cell vaccines revealed that nonspecifically stimulated outbred white leghorn-type cockerels had higher incidences of tumors than did controls. a study of tumor cell cytotoxicity of sera from marek's disease virus exposed birds indicated that humoral factors may play some role in tumor resistance.	1978	24754
abscesses of the frontal lobe of the brain secondary to covert dental sepsis.	the bacterial species found in pus aspirated from brain abscesses in two patients were typical of those found in dental sepsis. subsequently apical-root abscesses were demonstrated in the upper jaws of both patients. this evidence strongly suggests that these cerebral abscesses were secondary to dental sepsis which could have spread from the teeth to the frontal lobes by several possible antaomical pathways.	1978	79867
role of mononuclear infiltrating cells in pathogenesis of hepatitis.	mice that have been injected with corynebacterium parvum have mononuclear-cell infiltrates in the liver lobules. in such mice a small dose of lipopolysaccharide endotoxin produced a lethal hepatitis, with high serum-transaminase concentrations, glycogen depletion, and hypoglycaemia. it is suggested that lipopolysaccharide triggers the release from the infiltrating mononuclear cells of factors toxic for hepatocytes. similarly certain parasitic and virus infections and graft-versus-host reactions ...	1978	80531
possible mechanisms underlying the induction of cytotoxic macrophages by corynebacterium parvum: in vitro induction of cytotoxicity in normal macrophages by immune lymphocytes.		1978	81874
corynebacterium parvum and hyperthermia.		1978	82029
malignant angioendothelioma--effect of immunotherapy with corynebacterium parvum.		1978	83086
treatment of acne vulgaris with topically applied erythromycin and tretinoin.	a twice daily application of 2% erythromycin base in hydroalcoholic solution accompanied by once daily use of 0.05% tretinoin (retinoic acid) solution was substantially more effective than tretinoin or erythromycin alone for treatment of inflammatory acne of moderate severity. therapeutic enhancement by this combination can be attributed to the different modes of action, erythromycin acting chiefly by suppressing propionibacterium acnes, while tretinoin is comedolytic. in addition, by altering t ...	1978	83088
[immunostimulation].		1978	84450
effect of immunomodulators on thymocyte suppressive activity in mice.		1978	28950
the role of bacteria in acne vulgaris: a new approach.		1978	32979
complement activation by propionibacterium acnes and bacteroides melaninogenicus.		1978	33641
intergeneric and intrageneric inhibition between strains of propionibacterium acnes and micrococcaceae, particularly staphylococcus epidermidis, isolated from normal skin and acne lesions.	two hundred and forty-one strains or resident skin bacteria comprising 93 isolates of propionob acterium acnes and 148 of micrococcaceae derived from 36 acne patients and 8 control subjects were screened for their ability to inhibit 32 indicator strains, including 20 strains of p. acnes and 12 strains of staphylococcus epidermidis derived from patients with all grades of acne and from normal skin. fifty-three strains (22%) showed some activity against at least one indicator strain. both broad- a ...	1979	34728
[the bacterial flora of preputial space].	the bacterial flora of the preputial space of 210 healthy males (43 children aged between 2 and 11 years, 137 males between 12 and 60 years and 30 men over 60 years) was determined by smears and cultueres from glans penis, sulcus coronarius and the adjacent prepuce. the results were grouped according to various criteria, e.g. glans covered or uncovered and age of males. differences in the distribution of germs could be found in relationship to age. in the case of an uncovered glans penis the pre ...	1979	35486
purification and partial characterization of hyaluronate lyase (ec 4.2.2.1) from propionibacterium acnes.	hyaluronidase from propionibacterium acnes has been purified 13,000-fold from the culture supernatant to homogeneity (as determined by polyacrylamide disc gel electrophoresis). the molecular weight of the purified enzyme was 85,110 as determined by gel filtration. the purified enzyme had a ph optimum at 6.4, was stable between ph 5 and 5.8 and was completely inactivated after 15 min at 50 degrees c. preliminary studies suggested that the enzyme is active against chondroitin 4- and 6-sulphates, b ...	1979	43356
production of hyaluronidase by propionibacteria from different origins.	114 strains of anaerobic and microaerophilic coryneform bacteria from different origins were investigated for production of free extracellular hyaluronidase (hyaluronate glycanohydrolase, ec 3.2.1.36). a quantitative technique was applied measuring the release of n-acetyl-glucosamine groups from purified human potassium hyaluronate. the strains belonged to the following species: propionibacterium acnes, p. avidum, p. granulosum, p. lymphophilum, the formerly so-called corynebacterium parvum, p. ...	1979	44604
evidence for the presence of an antitumor factor in serum of normal animals.	we have previously reported finding a factor with antitumor activity (tnf, tumor necrosis factor) in extracts of serum from normal mice. the possibility that tnf exists in the blood of normal animals of other species was explored. horse, mouse, dog, human, sheep, calf, rat and shark serums were fractionated with (nh4)2so4 and filtered through s-200 sephacryl gel. proteins of molecular weight 90,000 to 180,000 were pooled, concentrated and dialyzed. tnf, determined by l-cell assay in vitro and me ...	1979	86384
effect of propionibacterium acnes on the cellular immune responses to tumor-specific antigens on malignant rat liver cells.	the effect of propionibacterium acnes on the cellular immune responses to tumor-specific membrane antigens was investigated by microcytotoxicity assays (ma) and 51cr release assays (cra) with use of mesenteric lymph node cells (lnc) of syngeneic bd iv and bd vi rats. bd rat liver cell lines transformed in vitro by chemical carcinogens were used as target cells with tumor-specific antigens. by ma, the lnc from rats that were inoculated with malignant liver cells under the adjuvant effect of heat- ...	1979	86635
immunotherapy models in experimental animals.		1979	87018
precursors of the blood group mn antigens as human carcinoma-associated antigens.		1979	88088
chemotherapy of advanced head and neck cancer with methotrexate, bleomycin, and cis-diamminedichloroplatinum ii in an effective outpatient schedule.	thirty-one patients with advanced cancer of the head and neck, twenty-six of whom had failed prior irradiation, were treated with an out-patient chemotherapy regimen combining methotrexate, bleomycin, and cis-diamminedichloroplatinum (ii). the overall response rate among evaluable patients was 61%, with 22.5% complete remission. if 6 additional patients not completing 3 weeks of treatment are included, the response rate was 51.4%. the median duration of partial remission was 3 months, but none o ...	1979	88256
immunological cross-reactivity of oral non-streptococcal bacteria with mammalian tissue.	the presence of cross-reacting antigens between oral non-steptococcal bacteria and human and monkey tissue was investigated by indirect immunofluorescence. rabbit antisera, prepared against 22 oral bacteria, were incubated with cryostatcut sections of heart, skeletal muscle, brain cord, liver, kidney, and skin. a cell wall antigen of lactobacillus casei was shared with neuroglial brain cells, and an antigenic component of propionibacterium acnes was shared with kidney glomeruli. tissue-reactive ...	1979	110702
antibiotic sensitivity of comedonal propionibacterium acnes.	previous studies on antibiotic mic levels for p. acnes and p. granulosum have shown them generally sensitive to therapeutic levels in both blood and surface lipids. the clinical response of acne vulgaris to antibiotic therapy is slower than one would anticipate from in vitro studies. it is also delayed well beyond the time tetracycline is known to appear in surface lipids. the concentration of antibiotics in comedonal material could be important, but it is not known. to determine the sensitivity ...	1979	94223
studies of the producer cell of interferon in human lymphocyte cultures.	the producer cells of interferon were studied in human leucocyte cultures stimulated by a variety of stimulants, including phytohemagglutinin (pha), pokeweed mitogen (pwm), corynebacterium parvum (cp) and herpes simplex virus (hsv). when the cells were fractionated by the use of neuraminidase-treated sheep red blood cells (srbc), the t cell population responded with interferon production to pha and pwm but not to cp or hsv. however, the non-t population showed a vigorous response to the latter t ...	1979	94306
quantitation of skin bacteria: lethality of the wash solution used to remove bacteria.	a widely used technique for the quantitative removal of bacteria from the skin uses a detergent, triton x-100 (p, t-octylphenoxynonaethoxyethanol), to remove and suspend the bacteria. we determined the half-life for the survival of five common skin bacteria suspended in the solution. the shortest-lived was streptococcus pyogenes with a half-life of 0.9 hours. all of the others (propionibacterium acnes, staphylococcus epidermidis, staphylococcus aureus, and klebsiella pneumoniae) had half-lives o ...	1979	93373
immunity to carcinogen-induced transplantable fibrosarcomas in b2/b2 chickens. iv. effect of whole-body gamma radiation on localization and growth of intravenously injected tumor cells.		1979	112314
purification of antibodies to bacterial antigens by an immunoadsorbent and a method to quantify their reaction with insoluble bacterial targets.	a combination of procedures was employed to develop a radioimmunoassay which quantified the binding of antibodies to antigens of either intact propionibacterium acnes or to antigens of insoluble extracts derived from the bacteria. reactive antibody populations were purified by use of bacterial immunoadsorbents which were prepared by coupling p. acnes to diethylaminoethyl cellulose. binding of antibodies was detected with [125i]staphylococcal protein a ([125i]spa) and optimal conditions for the a ...	1979	113462
particulate beta 1-3 glucan and casual prophylaxis of mouse malaria (plasmodium berghei).		1979	121199
tumor growth inhibition and potentiation of immunotherapy by indomethacin in mice.	indomethacin was continuously administered in the drinking water of inbred c3h mice given grafts of syngeneic 3-methylcholanthrene-induced fibrosarcomas. a minor proportion of these animals died at the same time as the untreated controls, and others completely rejected their tumors; however, in most cases, the tumor growth rate was significantly slowed, and growth recommenced rapidly after drug withdrawal. this was the pattern for tumors either in their 10th to 14th transplant generation or only ...	1979	281566
in vivo antitumor activity of various forms of delayed-type hypersensitivity in mice.	relationships among various forms of delayed-type hypersensitivity (dth) and nonspecific resistance to lewis lung tumor were studied in syngeneic and semisyngeneic mice. only the tuberculin type of dth obviated a virulent inoculum of 10(6) tumor cells. the jones-mote type of dth, even modified by cyclophosphamide pretreatment, produced a significant local inflammatory reaction which was unable to destroy tumor cells. the antitumor effect of the tuberculin type was observed in bcg-or in corynbact ...	1979	283275
further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. ix. macrophage content of tumors in mice.		1979	285276
radiation-induced osteogenic sarcoma of c3h mouse: effects of corynebacterium parvum and wbi on its natural history and response to irradiation.		1979	285860
further observations on the inhibition of tumor growth by corynebacterium parvum with cyclophosphamide. x. effect of treatment on tumor cell kinetics in mice.		1979	286125
an evaluation of corynebacterium parvum during remission maintenance therapy in pediatric patients with acute lymphoblastic leukemia.	the biologic impact and clinical toxicity of corynebacterium parvum administered at a dose of 5 mg/m2 by intravenous or subcutaneous routes were evaluated in 18 children receiving combination chemotherapy for maintenance of acute lymphoblastic leukemia (all) in remission. several nonspecific immunologic and hematologic parameters were evaluated. patients were also monitored for changes in cutaneous sensitivity to histamine. no changes in any parameter were observed in patients after only one cou ...	1979	287855
prostaglandin-like substances in propionibacterium acnes ii. stimulatory effect on ovarian cyclic amp.	the prostaglandin-like substances (pls) from propionibacterium acnes increased the ovarian tissue levels of cyclic amp (camp) approximately 2-fold. the lipid material extracted from p. acnes thus behaved like pg's of the e-type, and since it is unlikely that other known stimulators of the ovarian camp system can be present in the bacterial lipid fraction, these experiments give further evidence in favour of the occurrence of pls in p. acnes.	1979	217719
low trimethoprim susceptibility of anaerobic bacteria due to insensitive dihydrofolate reductases.	all the 28 bacteroides fragilis strains investigated were susceptible to sulfamethoxazole (minimal inhibitory concentration < 16 mug/ml) and resistant to trimethoprim (tmp; minimal inhibitory concentration > 4 mug/ml). synergism between sulfamethoxazole and tmp was present in all strains at a ratio of 1:1. the few clostridia investigated proved more resistant to both compounds. dihydrofolate reductases from b. fragilis, c. perfringens, and some other anaerobic species were isolated. inhibition p ...	1979	218496
chemical properties of the principle in c. parvum that produces splenomegaly in mice.	suspensions of wellcome c. parvum strain 6134 produce splenomegaly in mice when injected i.p. in amounts as low as 20 microgram. this lymphoreticular stimulatory activity is extremely sensitive to cell breakage and is abolished by heating for 4 h at 100 degrees. periodate oxidation of the bacteria destroys their capacity to produce splenomegaly and abrogates the agglutination of intact c. parvum by con a. mild hcl hydrolysis also abolished the splenomegaly but phenol:chloroform:ether and chlorof ...	1979	220183
nicotinamide adenine dinucleotide-splitting enzyme in normal, elicited and activated peritoneal macrophages of the mouse.		1979	222905
generation of cytotoxic lymphocytes against human tumor cells in vitro by various soluble microbial extracts.		1979	222929
antitumor activity and lymphoreticular stimulation properties of fractions isolated from corynebacterium parvum.		1979	225023
immunotherapy of lung cancer. ii. review of clinical trials in small cell carcinoma.		1979	226262
nor-mdp, saponin, corynebacteria, and pertussis organisms as immunological adjuvants in experimental malaria vaccination of macaques.	vaccination of primates against malaria using antigen derived from erythrocytic parasite stages has been most successful where freund's complete adjuvant has been employed. since this adjuvant is clinically unacceptable its replacement is a matter of urgency.in the present work a muramyldipeptide derivative (nor-mdp) given in mineral oil has proved to be partially effective as an adjuvant for merozoite vaccination of macaca mulatta against plasmodium knowlesi, and saponin has proved to be effect ...	1979	232428
functional similarity and diversity in peritoneal macrophage populations induced in vivo by various stimuli.		1979	232817
[effect of silica on the anti-tumour activity of "corynebacterium parvum" (author's transl)].	silica, a specifically toxic substance for macrophages, has been used to study the role of these cells in the corynebacterium parvum-induced anti-tumour protection. in the two experimental tumours studied, silica, c. parvum and tumour cells were injected by the same route: the intravenous route in the case of lymphosarcoma in xvii mice and the intraperitoneal in that of mammary carcinoma in c3h mice. the inhibition of the anti-tumour effect of c. parvum by the administration of silica was more p ...	1979	232975
[hematological observations in patients following immunostimulation through intrapleural application of corynebacterium parvum].	the ludwig lung cancer study group aims to investigate the role of immunotherapy as adjuvant treatment modality in operable non-small cell bronchial carcinoma. the participants are 12 european clinics and institutes. with a proven accrual of 350 patients per year the group offers a sharp tool in clinical oncology with regards to bronchial carcinoma. the accrual phase of the first trial was closed on february 2, 1979 with 475 patients, starting a new protocol on february 5, 1979. the ongoing rand ...	1979	233458
corynebacterium parvum as an adjuvant for trypanosoma cruzi epimastigote vaccines: a comparison with saponin and bordetella pertussis.	the effect was compared in cba mice of adding corynebacterium parvum, saponin, and bordetella pertussis to living or killed trypanosoma cruzi (y strain) epimastigote vaccines on the induction of protective immunity against subcutaneous (s.c.) challenge with blood trypomastigotes. the addition of c. parvum to a low dose of t. cruzi vaccine, which alone was non-protective, generated a greater degree of protection than did saponin or b. pertussis. c. parvum alone increased resistance to infection t ...	1979	216967
the immunobiology of acne. a polyvalent proprionibacteria vaccine.		1979	154393
[current theories on the pathomechanism of acne juvenilis].		1979	155812
[differentiation of various propionibacterium species from acne-vulgaris efflorescences].	samples of pustules taken from 37 patients with acne (a. vulgaris, a. papulopustulosa, a. conglobata) were examined using different culture mediums for the growth of anaerobic to microaerophilic coryneforms. we identified 46 isolates of propionibacteria which were tested according to their morphological, biochemical, serological, and phagelysotopic reactions. three types of propionibacteria were found: p. acnes (33), p. granulosum (11) and p. avidum (2). nine samples showed p. acnes combined wit ...	1979	156167
the feasibility of replacing antibiotics by quaternary ammonium compounds in topical antimicrobial acne therapy.	determinations of the minimum inhibitory concentrations for various antimicrobial surfactants with reference to the bacteria p. acnes, p. granulosum, and st. epidermidis are reported. the results show that quaternary ammonium compounds can display minimum inhibitory concentrations corresponding to those of relevant antibiotics. with the especially effective substance fractionated dimethylcocobenzalkoniumchloride )arquad dmmcd-b), it could be further shown that with in vivo application in 70% iso ...	1979	157107
cytostatic effect on tumour cells induced in human monocytes by mediators from bcg-stimulated lymphocytes and mlc.	human monocytes activated by mediators (lymphokines) from bcg-stimulated, sensitized lymphocytes (from bcg-vaccinated donors) were cytostatic to a human cell line. mediators from allogeneic lymphocytes activated the cytostatic ability of monocytes to the same degree as mediators from autologous lymphocytes. mediators from bcg-stimulated lymphocytes from tuberculin-negative donors not vaccinated with bcg, activated the monocytes only to a small extent. culture of lymphocytes in a membrane chamber ...	1979	158283
complement activation in acne vulgaris: consumption of complement by comedones.	comedones, the contents of acne lesions, were shown to consume scomplement hemolytic activity in normal serum. this consumption was stimulated by the addition of serum from patients with inflammatory acne. absorption of acne serum with propionibacterium acnes cells removed all stimulating activity. immunoelectrophoretic analysis of serum incubated with comedones revealed the conversion of c3 and factor b in normal serum. the addition of acne serum resulted in cleavage of c4. in serum treated wit ...	1979	159261
bacterial flora of comedones.	open comedones from thirty-eight patients with acne vulgaris on the face or back were compared for microbial flora. a total of eighty-three comedones from the face and sixty-three from the upper back were individually processed for quantitative bacterial analysis. the greatest difference between the flora of comedones at these two sites was that 44.6% of comedones from the back (compared to 9.6% from the face) harboured no aerobic cocci. the decreased prevalence of staphylococci in the lesions f ...	1979	160242
extrusion of peritoneal catheter through abdominal incision: report of a rare complication of ventriculoperitoneal shunt.	a rare complication of a ventriculoperitoneal shunt is reported. the peritoneal catheter extruded through the well-healed abdominal incision. this is the first report of such an occurrence in an adult patient.	1979	160511
comparison of natural killer cells induced by kunjin virus and corynebacterium parvum with those occurring naturally in nude mice.	natural killer (nk) cells are rapidly elicited in the spleen and peritoneal cavity of mice inoculated intravenously or intraperitoneally with live kunjin virus, and more slowly in the peritoneal cavity of mice inoculated intraperitoneally with formalin-inactivated corynebacterium parvum. nk cells induced by either agent display cytotoxicity for a similar spectrum of syngeneic, allogeneic, and xenogeneic cultured cell lines. by contrast, the cells occurring naturally in the spleen of congenitally ...	1979	160889
acne.	the cause of acne is still obscure, but genetic predisposition, sebaceous overactivity, overgrowth of bacterial flora and exposure to comedogenic substances are all significant factors. acne lesions occur mainly in sebaceous follicles, which are characterized by deep follicular canals and large sebaceous glands. the associated seborrhea is not due to a circulatory excess of androgens but may be caused by a local amplification of androgenic activity. this, in turn, may be due to large numbers of ...	1979	161830
separation of functionally distinct subpopulations of corynebacterium parvum-activated macrophages with predominantly stimulatory or suppressive effect on the cell-mediated cytotoxic t cell response.		1979	312146
effects of corynebacterium parvum and bcg therapy on immune parameters in patients with disseminated melanoma. a sequential study over 28 days. ii. changes in non-specific (nk, k and t cell) lymphocytoxicity and delayed hypersensitivity skin reactions.	c. parvum and bcg produced significant changes in nk, k and t cell lymphocytotoxicity using a chang liver target cell. a consistent temporal pattern over 28 days of early depression, recovery, overshoot and then decline was described. this was particularly marked for c. parvum and 'k' cell activity. skin test reactivity to recall antigens at 28 days was not appreciably different from the pre-immunization reactivity. the importance of using lymphocyte concentration-cytotoxicity titration curves a ...	1979	312169
anaerobic and aerobic bacteriology of acute conjunctivitis.	aerobic and anaerobic cultures and clinical data were obtained from 131 patients presenting with acute conjunctivitis. similar cultures were obtained from 60 noninflamed individuals. anaerobes were isolated from 66 patients, 51 times in mixed culture with aerobes and 15 times (11.5%) as the only isolates. aerobes only were recovered in 54 patients. the organisms found to be statistically significantly more commonly recovered from eyes with conjunctivitis were staphylococcus aureus, hemophilus in ...	1979	313179
immunologic evaluation of patients with advanced head and neck cancer receiving weekly chemoimmunotherapy.	patients with advanced head and neck cancer have significant reduction in their circulating lymphocyte mass which is reflected in decreased numbers of t cells, fc receptor cells, and in derangements of t lymphocyte functions, i.e., decreased responsiveness to several dilutions of phytohemagglutinin and lack of development of delayed hypersensitivity to 2,4-dinitrochlorobenzene (70% of patients were dncb (-)). a population of phagocytic cells capable of decreasing lymphocyte responsiveness to mit ...	1979	313240
a trial of 5-fluorouracil and corynebacterium parvum in advanced colorectal carcinoma.	this study has confirmed that patients who have advanced colorectal carcinoma have impaired responsiveness to delayed-hypersensitivity skin testing, and also have elevated levels of serum igm. serial observations of delayed-hypersensitivity skin tests, total lymphocyte counts, t-lymphocyte counts, b-lymphocyte counts, and serum immunoglobulin levels failed to reveal any consistent pattern of responses in patients treated with either chemotherapy alone or chemoimmunotherapy. in 33 patients chosen ...	1979	313873
antigenic bacterial polysaccharide in rheumatoid synovial effusions.	phenol-water extracted rheumatoid synovial fluids and synovial fluid leukocytes contain an antigen immunologically identical to the proprionibacterium group bacteria. the antigen was identified by counter-immunoelectrophoresis in 70% of rheumatoid synovial fluid leukocyte pellets and in 60% of rheumatoid synovial fluids. it was also present in 6% of nonrheumatoid fluids and in 22% of nonrheumatoid inflammatory fluid leukocytes. antigen was not detectable in synovial samples before extraction. sy ...	1979	314293
effects of repeated corynebacterium parvum and bcg therapy on immune parameters: a weekly sequential study of melanoma patients. i. changes in non-specific (nk, k and t cell) lymphocytotoxicity, peripheral blood counts and delayed hypersensitivity reactions.	increased lymphocyte cytotoxicity, particularly of 'killer' k cell type was recorded with repeated immunizations of either c. parvum or bcg. a 3 week interval between immunizations was capable of maintaining the increase in cytotoxicity. no marked alterations of 'recall' skin hypersensitivity reactions nor of peripheral blood counts were noted. expression of cytotoxicity results as percentage 51cr release, lytic units/ml and cytotoxic capacity (after logit transformation of the cytotoxicity-lymp ...	1979	314367
stimulation of phosphatidylinositol turnover in the macrophage plasma membrane: a possible mechanism for signal transmission.		1979	315365
[preliminary considerations on the intravenous use of corynebacterium parvum in the treatment of solid neoplasms].		1979	315598
value of immune monitoring in gynecologic cancer patients receiving immunotherapy.	immunotherapy with nonspecific immunopotentiators such as corynebacterium parvum is under study in several areas of gynecologic oncology. the efficacy of this new modality awaits the results of carefully done clinical trials designed to measure an improved effect on survival when this and similar agents are added to conventional therapy. this report deals with an attempt to demonstrate enhancement of the cell-mediated immune response in a small number of patients with advanced ovarian (18 patien ...	1979	315714
association of host immunoglobulins with solid tumours in vivo.	using a direct radioimmune antiglobulin technique and a competitive double-antibody radioimmune assay, we have demonstrated the presence of appreciable amounts of host immunoglobulins on the surface and in extracts of cell suspensions from freshly excised solid tumours. iga appeared to have the greatest concentrations from freshly excised solid tumours. iga appeared to have the greatest concentration, followed in turn by igm congruent to igg2a greater than igg1 congruent to igg2b greater than ig ...	1979	315785
[the bacteriological and biological significance of propionibacterium acnes--the indigenous bacteria of human skin. iv. age-related change in antibody to p. acnes in normal human sera (author's transl)].		1979	316030
effects of endotoxin and extracts of pregnant mouse uterus on the recovery of hemopoiesis after 5-fluorouracil.	a single injection of endotoxin, 4 hours after administration of 150 mg/kg of 5-fluorouracil (5-fu), stimulated the recovery of bone marrow hemopoietic cells that form colonies in spleen (cfu-s) or in culture (gm-cfc), of erythropoiesis, and of platelet production. corynebacterium parvum injections had similar effects. endotoxin-free extracts of tissues (from pregnant mouse uterus, placenta, and embryo) which have a high content of the factor(s) capable of stimulating growth of gm-cfc in vitro a ...	1979	316724
inhibition of host resistance by nutritional hypercholesteremia.	previous experiments showed that nutritionally induced hypercholesteremia in mice caused an increase in susceptibility to coxsackievirus b, with a marked suppression of cellular infiltrates in infected tissues and an increased mortality. the present studies demonstrated that a hypercholesteremic diet was associated with an inhibition in host resistance as measured by susceptibility to listeria monocytogenes infection and the growth of two transplanted syngeneic murine tumors. moreover, the abili ...	1979	317596
response of lympho-hemopoietic tissue to corynebacterium parvum by study of dna enzymes and h3-tdr metabolism.	the effects of corynebacterium parvum on the lymphohemopoietic tissues of mice was investigated by h3-tdr metabolism, organ weights, dna-polymerase-alpha activity and terminal deoxynucleotidyl transferase (tdt) activity. marked increase in spleen size occurred. the increase in size was accompanied by increases in dna-p-alpha activity and h3tdr uptake. this indicated that the spleen was a major site of cell proliferation and of increase in population size after c. parvum stimulation. thymus and b ...	1979	317898
inhibitory effect of propionibacterium acnes on the growth on syngeneic tumor transplants in nude mice.		1979	318050
effect of host immune capability on radiocurability and subsequent transplantability of a murine fibrosarcoma.		1979	291749
effect of corynebacterium parvum and chronic toxoplasma infection on metastatic brain tumors in mice.		1979	291750
[initial experiences with a nation-wide austrian study of adjuvant chemo- and immunotherapy of colorectal cancer following radical surgery].	the outline of a cooperative study for adjuvant chemo-immunotherapy on radically operated colon-rectum-carcinoma, is presented. one group of patients receiving placebo, has to be randomized against another group who postoperatively received chemo-immunotherapy consisting of 5-fluorouracil and ccnu and corynebacterium parvum, which was administered intermittently, throughout one year. patients with rectum-carcinoma additionally receive radio-therapy with 1500 rad hd before surgery and 4500--5000 ...	1979	299221
[histopathological aspects and macrophage reactivity in rats with guerin's t8 viral tumor after treatment with corynebacterium parvum].		1979	262125
cocarcinogenesis.		1979	367444
[current status of immunotherapy of malignant tumors].		1979	367730
immunotherapy of solid tumor.		1979	375448
defective tumoricidal capacity of macrophages from a/j mice. i. characterization of the macrophage cytotoxic defect after in vivo and in vitro activation stimuli.	macrophages from a/j mice fail to develop tumoricidal activity after any of several in vivo or in vitro treatments that activate cells from c3h/hen mice. peritoneal macrophages from a/j mice treated i.p. with viable mycobacterium bovis, strain bcg, killed corynebacterium parvum, or pyran copolymer fail to develop in vitro tumoricidal activity; varying the numbers of macrophages from treated mice added to target cells, or the dose and time of treatment, or the treatment schedule of these in vivo ...	1979	376720
in vitro killing of schistosomula of schistosoma mansoni by bcg and c. parvum-activated macrophages.	resistance to schistosoma mansoni infection in the mouse has been induced either specifically by a primary infection with this parasite or nonspecifically by a variety of immunostimulants such as bcg. in the present study we developed an in vitro system to examine the effector mechanism of nonspecifically induced resistance. activated macrophage monolayers obtained from bcg- or corynebacterium parvum treated mice killed a respective mean 32 +/- 6% and 48 +/- 5% of schistosomula after 24 hr incub ...	1979	376723
current state of clinical immunotherapy.		1979	377611
effect of adriamycin and corynebacterium parvum in tumor-bearing mice: modulation of response to sheep red blood cells.	administration of adriamycin and corynebacterium parvum alone in c57bl/6j mice bearing lewis lung carcinoma stimulated the direct (19s) and indirect (7s) plaque-forming cell (pfc) response specific for sheep red blood cells. thus adriamycin appears to possess some immunostimulatory effect on tumor-bearing mice with much less effect than c. parvum alone. simultaneous administration of adriamycin and c. parvum decreased the pfc response compared to that for c. parvum alone. this decrease may indic ...	1979	379400
corynebacterium parvum: effects on the biochemistry of mouse serum and liver.		1979	379402