Publications

cytomegalovirus and herpes simplex virus: wolves in sheep's clothing.	the herpesviruses cytomegalovirus and herpes simplex are common human infections. they are usually subclinical, but can cause significant or even fatal disease. the foetus, the newborn and the immunocompromised are particularly vulnerable to the serious consequences of these opportunistic infections.	1978	208498
characterization of multiple forms of histone phosphatase in rat liver.	by using chromatography on deae-cellulose, aminohexyl-sepharose 4b and sephadex g-200, rat liver extract was shown to contain at least three fractions, ia, ib and ii, of histone phosphatase. fractions ia and ii are probably the same enzymes as the previously described glycogen synthase phosphatase and phosphorylase phosphatase, respectively, but ib exhibits noticeable activities only with phosphohistone as substrate. approximate molecular weights of 69 000, 300 000 and 160 000 were determined by ...	1978	208620
[serologic studies on cytomegalic inclusion disease frequency in the karl-marx-stadt area].		1978	209241
prednisolone-3, 20-bisguanylhydrazone: na+, k+-atpase inhibition and positive inotropic action.	the relationship between two known actions of prednisolone-3, 20-bisguanylhydrazone (pbgh); na+, k+-atpase inhibition and positive inotropic effects, was investigated. in electrically driven left atrial preparations of guinea pig heart, the positive inotropic action of pbgh was not affected by beta-adrenergic or histamine antagonists. pretreatment of animals with reserpine also failed to influence the positive inotropic action of pbgh. inotropic concentrations of pbgh inhibited na+, k+-atpase an ...	1978	149010
effect of glucocorticoids and stress on 14c-thymidine incorporation into dna and on mitosis in regenerating rat liver.	hydrocortisone sodium succinate (65 mg/kg body weight), zn-acth (40 u/kg) and the intraperitoneal injection of celite (200 mg/kg) decrease the incorporation of 14c-thymidine into the dna of regenerating rat liver by about 60%. this decrease is not followed by a corresponding inhibition of cell division. the agents applied at the end of g1 phase or in the s phase of the cell cycle probably change thymidine metabolism and the observed decrease of thymidine incorporation does not represent true inh ...	1978	149320
[state and development of the progeny of rats subjected to androgen skin application in the course of the entire pregnancy].		1978	149706
experimental spongy degeneration of the white matter induced by 6-aminonicotinamide intoxication.	spongy state and degeneration of the white matter in the 6-aminonicotinamide intoxicated rats were studied neuropathologically and electromicroscopically. young albino rats, four weeks of age, received 0.1% of 6-aminonicotinamide solution intraperitoneally as a single dose of 10 mg/kg of body weight. four hours after the administration, paralysis of the hind limbs occurred in the rats. neuropathological investigations revealed a characteristic spongy and degenerative change of white matter as we ...	1978	149717
some behavioral effects of serotonin depletion depend on method: a comparison of 5,7-dihydroxytryptamine, p-chlorophenylalanine, p-choloroamphetamine, and electrolytic raphe lesions.		1978	152081
altered activity of hepatic mixed-function mono-oxygenase enzymes in streptozotocin-induced diabetic rats.	1. in streptozotocin-induced diabetic male rats, hepatic microsomal aminopyrine n-demethylase activity was depressed, whereas aniline hydroxylase activity and cytochrome p-450 content were increased over control values. 2. in diabetic female rats, hepatic microsomal aminopyrine n-demethylase activity, aniline hydroxylase activity, biphenyl 4-hydroxylase activity, and cytochrome p-450 content were increased over control values. 3. insulin treatment of diabetic male and female rats antagonized all ...	1978	152519
an artificial 'haemophilic' plasma for one-stage factor-viii assay.	an 'artificial' plasma for one-stage factor-viii assays is made by incubating human plasma with edta, to destroy factor viii, and afterwards removing the anticoagulant by dialysis. bovine factor v is then added to a given level. in the assay, contact activation is controlled by adding contact product. it was confirmed that factor-viii activity was destroyed and that the edta was freely dialysable. the fibrinogen in the treated plasma clotted normally with thrombin. likely variation in the factor ...	1978	107960
[cleavage of lactulose by bacillus megaterium].		1978	111429
[note about the biology of cuterebra apicalis (guérin, 1829/38) (diptera-cuterebridae) (author's transl)].	this note reports the parasitism by cuterebra apicalis guérin (1829/1838) on the rodents oryzomys eliurus and calomys callosus collected in the north of formosa county, goiás state. the infested animals were kept in the laboratory to allow observations on the development of the parasite.	1978	108773
[clinical, parasitological and serological investigations in sarcosporidiosis (sarcocystis suihominis) of man (author's transl)].	eight medical students ate for a test raw meat from a pig experimentally infected with sporocysts of sarcocystis suihominis. the meat had been officially controlled before and was found free of trichinella and qualified for consumption. 6 to 24 hours after the meal all persons suffered from acute clinical symptoms, above all diarrhoea and vomiting, coldness and sweating which decreased, however, within 12 to 24 hours. clinical-chemical investigations made during this time suggested an acute infe ...	1978	98426
altered mrna metabolism in ribonuclease iii-deficient strains of escherichia coli.	the metabolism of mrna from the lactose (lac) operon of escherichia coli has been studied in ribonuclease (rnase) iii-deficient strains (rnc-105). the induction lag for beta-galactosidase from the first gene was twice as long, and enzyme synthesis was reduced 10-fold in one such mutant compared with its isogenic rnc+ sister; in the original mutant strain ab301-105, synthesis of beta-galactosidase was not even detectable, although transduction analysis revealed the presence of a normal lac operon ...	1978	98520
evolution of immunoglobulin subclasses. primary structure of a murine myeloma gamma1 chain.	the amino acid sequences of the first six cnbr fragments (303 residues) of mopc 21 heavy chain have been determined, using conventional techniques. this completes the determination of the covalent structure of mopc 21 immunoglobulin (igg1, k). mopc 21 gamma1 chain is a unique sequence of 440 amino acid residues. the variable region is homologous with human vhiii sequences. a comparison of the constant region with homologous sequences shows that mouse gamma1 and gamma2 proteins differ much more t ...	1978	98524
cell characteristics of cultured glomeruli from different animal species.	a modified sieving technique has been developed to isolate pure glomeruli from monkey, sheep, dog, rabbit and rat kidney. glomeruli from all these species have been grown in tissue culture and the glomerular cell outgrowth studied by light microscopy and time-lapse cinemicroscopy. the pattern of growth was the same for all the species studied. in all species, three cell populations have been identified with the features of epithelial cells, mesangial cells and macrophages, although the latter po ...	1978	105300
[effect of polychlorinated biphenyls in the rat: ii.--preliminary report on metabolic alterations (author's transl)].	rats were fed with a diet containing 10 and 100 ppm (wet weight) of phenoclor dpr for 4 weeks in order to evaluate the toxicity of a french pcb mixture. the influence of pcb was studied by determining the liver weights, the hepatic and muscular proteins, glycogen and humidity content as well as hematocrite, glucose, proteins and lipids in the plasma, and the lipidic contents of the liver and the carcass. there was a significant increase in both liver to body weight ratios and liver lipid and pro ...	1978	105425
case report: intestinal clearance of calcium and protein in waldenstrom's macroglobulinemia.	a 63-year-old man with waldenstrom's macroglobulinemia had severe steatorrhea, marked protein-losing enteropathy, and excessive endogenous fecal calcium clearance. the malabsorption and protein loss resulted in weight loss and hypoalbuminemia. in contrast, the striking enteric calcium loss was completely compensated by an increase in calcium absorption resulting in a positive calcium balance.	1978	105640
[quantitative method of assessing the virulence of mycobacterium tuberculosis in an experiment on guinea pigs].		1978	97664
isolation care of infection-prone burn patients.	an experimental and clinical study of spread of colonisation between burn patients, and their susceptibility to infection, was performed. burn patients' polymorphonuclear neutrophil granulocytes (pmn) functioned poorly, particularly during the second week after injury which coincided with maximum growth of bacteria in the burn wound. patients with large burns often dispersed s. aureus and ps. aeruginosa but also beta-hemolytic streptococcus to the air of their rooms. airborne transfer of these b ...	1978	97776
localization of primate calls by old world monkeys.	monkeys (macaca) were trained by operant conditioning techniques to report the minimum detectable change in location of a sound in space, and were tested with a series of recorded coo or clear call vocalizations. acuity of localization varied from approximately 4 degrees to 15 degrees and was a function of the magnitude of the change in pitch (frequency modulation) of the different clear calls.	1978	97785
alterations of intercellular junctions in acinic cell carcinoma of the canine pancreas.	intercellular junctions in spontaneous canine pancreatic acinic cell adenocarcinomas were compared to those in control canine pancreas. the neoplastic cells displayed proliferation and fragmentation of tight junctions and reduction in size and number of gap junctions. marked decrease in desmosomal density was observed only in the poorly differentiated carcinoma. in the well differentiated carcinomas a few of the desmosomes were characteristic of those found in squamous cells. no quantatitive or ...	1978	97855
electron microscopic morphometric analysis of human t and b peripheral blood lymphocytes.	using the system of morphometric analysis described in this paper, human peripheral blood t and b lymphocytes, labeled with specific surface markers, can be compared on different analytical levels. they show differences in their surface and the eccentricity of cells, in the relative surfaces occupied by peripheral and central condensed chromatin, in the average surface of the central chromatin clumps and in the number of perichromatin granules per nuclear surface. the morphometric analysis revea ...	1978	97857
a human studying the sensing of chemicals by bacteria.	a new frame of reference, which in its fundamental structuring differs radically from the structuring of the familiar western indo-european viewpoints (logical, mathematical, scientific, philosophical, etc.), already exists. recently, by the strategem of systematically disallowing a previously unnoticed untenable assumption encoded in the traditional western symbolic logics, set theories, etc., in particular and in the western 'world-view' in general, this frame of reference has generated its ow ...	1978	97887
menstruation in intraocular endometrial transplants in the rhesus monkey.		1978	98044
effects of various divalent cations on the survival of neisseria gonorrhoeae in liquid media.	the effect of various concentrations of divalent cations on survival of gonococci in liquid medium was studied. the growth of neisseria gonorrhoeae was inhibited by manganous chloride in concentrations above 1 x 10(-5)mol/l while the growth of control organisms such as neisseria meningitidis and escherichia coli was not inhibited by the same salt even at 1 x 10(-2)mol/l. copper sulphate, cobaltous nitrate, nickel chloride, and zinc sulphate also had deleterious effects on gonococci. magnesium ch ...	1978	98204
trh-like immunoreactivity in urine, serum and extrahypothalamic brain: non-identity with synthetic pyroglu-hist-pro-nh2 (trh).	trh-like immunoreactive substances obtained from several areas of rat brain and from human serum and urine were chromatographically separated by tlc and the resulting immunoreactive 'elution profiles' compared with that obtained for pyroglu-hist-pro-nh2 (trh). for hypothalamus and septal-preoptic samples trh was present, but represented less than 100% of the immunoreactive substances. for cortex, amygdala, brain stem, serum and urine, no trh was detectable in the immunoreactive substances from t ...	1978	98209
[investigations of the incidence of neisseria gonorrhoeae on the pharyngeal mucosa (author's transl)].		1978	98235
effect of a lipid load on blood and urinary carnitine in man.	blood and urine carnitine contents have been determined in patients before and after a lipid load and in patients on haemodialysis. oral and intravenous lipid administration significantly depressed blood carnitine content and after 500 ml intravenous intralipid urinary carnitine excretion fell by 43%. blood carnitine was reduced by 50% by haemodialysis and returned to the pre-dialysis value within 20 h in 5 out of 8 patients. it is concluded that the blood carnitine level is normally controlled ...	1978	98245
leukaemia-associated antigens in man.		1978	98250
vasodilation, fibrinolysis, and thrombolysis with intraarterial infusion of urokinase in the canine superior mesenteric artery.	urokinase, the plasminogen activator from human urine, produces a dose-dependent increase in blood flow in the canine superior mesenteric artery when injected intraarterially at doses from 10(-1) to 10(3) units kg-1. this vasodilation persists despite blockade of beta-adrenergic and histamine h1 and h2 receptors as well as inhibition of plasminogen activation, suggesting that these mechanisms are not involved. infusion of urokinase at 10(2) cta (committee on thrombolytic agents) units kg-1 min-1 ...	1978	98390
chronotropic response of isolated atria to acid base alterations.	the effect of acid-base alterations on spontaneous rate was analysed using isolated atria exposed to cumulative degrees of acidosis produced either by adding hcl or by increasing pco2 in the incubation medium. frequncy vs. ph curves were made to assess chronotropic response to acid-base changes. heart rate was increased in alkalosis and decreased when the ph of the medium was lowered. both "respiratory" and "metabolic" alterations affected the contraction rate to the same extent. decreasing ph f ...	1978	87182
heterologous radioimmunoassay for rabbit prolactin.	a highly specific heterologous double-antibody ria has been developed to measure rabbit prl by using guinea pig antiserum to human prl and ovine [125 i]iodo-prl. rabbit pituitary prl and serum give parallel dose-response curves in the assay and no cross-reaction (less than 0.1%) occurs with gh, placental lactogens, lh, fsh, or tsh from several different species. the assay is suitable for the measurement of human, ovine, bovine, caprine, and canine prl in addition to rabbit prl, but shows no cros ...	1978	105878
synchronous, sustained oscillation of c-peptide and insulin in the plasma of fasting monkeys.	the previously reported synchronous oscillations in plasma glucose and insulin levels have been further studied to determine whether the phenomenon can be attributed to cyclic secretion or degradation of the hormone. plasma c-peptide concentrations were measured and found to cycle with the same period as plasma insulin suggesting that the oscillations of insulin arise from changing secretion rather than degradation. the amplitude of c-peptide oscillation was 50 percent that of insulin. assuming ...	1978	105880
anti-kappa/lambda immunobead for detection of human b lymphocytes.	several methods were compared for quantitating the b lymphocytes in human peripheral blood. rbc rosette assays including sheep and bovine red blood cells, and immunobead rosette assays including beads coated with anti-kappalambda and trivalent anti-gam antibodies respectively were investigated. the anti-kappalambda bead assay proved to be simpler, faster, higher in reproducibility, and appeared to be more accurate than any of the other assays.	1978	105987
macaca assamensis as a new host for experimental plasmodium knowlesi infection.		1978	108217
selective habitation of bacteria on "intermediate soft" keratin surfaces of the rat tongue.	scanning and light microscopy reveals a selective and restrictive pattern of indigenous bacterial colonization on the tongue of rats which is accounted for by the preferred attachment of bacteria to an "intermediate soft" keratin substrate. total intravenous feeding of rats for 10 days did not alter this colonization pattern indicating that oral intake of food is not responsible for maintenance of this pattern.	1978	98542
visual-field displacements in human beings evoked by accoustical transients.	sixty-two of 133 subjects reported visual-field displacements when they were exposed to intense (125 db spl) repetitive audiofrequency transients. this phenomenon was investigated in three experiments. frequency (100-5000 hz) was varied in experiment i; repetition rate (0.5/s--6.0/s) was varied in experiment ii; acoustical transient onset/offset time (0.2--25 ms) was examined in experiment iii. the results of these three experiments indicated that the largest proportion of displacement reports a ...	1978	98550
evidence that bovine conglutinin reacts with an early product of c3b degradation, and an improved conglutination assay.	when eac43b were treated with heated serum in edta, reactivity with bovine conglutinin appeared rapidly, even at 0 degrees c, and almost simultaneously with the loss of c3b rosetting capacity. at the time conglutinability first appeared, there was no detectable decrease in i-a or hemolytic c3 activity, and no detectable c3 antigen release from the cells. with prolonged exposure to heated serum in edta, i-a (immune adherence) and hemolytic c3 activity were lost. if this exposure was at 37 degrees ...	1978	98586
characterization and genetic control of the immune response to synthetic polypeptide antigens of defined geometry.	both humoral and cell-mediated immune responses to the synthetic helical hapten-carrier conjugate poly-glu-tyr-lys(tnp)-(glu-tyr-ala)5 were found to be linked to the major histocompatibility locus in mice and guinea pigs. the responder mouse strains (h-2d haplotype) showed a primary igm response with an igg component appearing after the secondary immunization. the antibody response was accompanied by a positive dth reaction in responder strains. nonresponder mice (h-2b or h-2k haplotypes) showed ...	1978	98587
gonorrhea detection in posthysterectomy patients.	a retrospective study of women examined at the venereal disease clinic after hysterectomy was made to determine which culture site was most likely to show anogenital neisseria gonorrhoeae infection when the cervix was absent. seventeen of 104 such patients were culture positive for n gonorrhoeae. rates of positivity for our culture sites were as follows: urethral, 17/17 (100%); vaginal, 7/17 (41%); and rectal, 2/17 (12%).	1978	98647
[shock lung (review of foreign literature)].		1978	98662
freedom, the will-o'-the-wisp.		1978	98690
localised insertion of new cell wall in bacillus subtilis.		1978	98715
electron-microscopic identification of axonal initial segments belonging to interneurons in the dorsal lateral geniculate nucleus of the monkey.		1978	98733
effects of d-amphetamine on temporal and spatial discrimination in rats.	rats were trained to lever-press for food reinforcers on a multiple schedule that had a fixed-interval (fi) and a differential reinforcement of low rate (drl) component. illumination of a stimulus light above the right-hand lever indicated that responses on this lever would be reinforced according to a fi 60-s schedule while responses on the left-hand lever were without programmed consequences. however, when the light above the left-hand lever was illuminated only responses on this lever were re ...	1978	98789
experimental spinal cord trauma, ii: blood flow, tissue oxygen, evoked potentials in both paretic and plegic monkeys.	graded clinical motor deficits were produced in a series of rhesus monkeys subjected to experimental spinal cord trauma from a variety of impact loads. an argon washout technique was used to measure spinal cord blood flow; tissue oxygen carbon dioxide, and somatosensory evoked potentials (seps) were also monitored. each animal received a clinical grade and, after a week of study, the spinal cords were removed for histopathological grading. blood flow in paraplegic animals was significantly decre ...	1978	98856
[experiments to reproduce paratyphoid in pigs of different ages].		1978	98900
quantitation of particles in the freeze-fractured nuclear membrane after renal ischemia.	changes in the number and sizes of membrane-associated particles have been quantitated in the protoplasmic (p) and exoplasmic (e) fracture faces of the outer membrane of nuclei isolated from the inner cortex following renal ischemia and reflow in the rat. no changes were observed in the inner nuclear membrane. after 20-min ischemia, the number of particles in both fracture faces decreased. with reflow, the total number of particles decreased after both 20- and 60-min ischemia. the partition coef ...	1978	98907
[some aspects relating to the aflatoxin generation during the self-heating of cereals].	in a stored batch of grain which was already affected by mould-formation tests were carried out with the known aflatoxin producer aspergillus flavus. a significantly lower aflatoxin production ensued if the mould growth was not connected with self-heating of the stored product. however, in conformity with increasing mould formation the germinating power was adversely affected and the significant signs (fatty acid number, reductive and none-reductive sugars) were influenced in the grain, irreleve ...	1978	98933
[measurement of the variations of cytoplasmic and nuclear volumes of the absorbing cells of the digestive tube according to the nutritional conditions, in the larva of the common toad (bufo bufo l.)].		1978	98945
jaundice and breast-feeding among alaskan eskimo newborns.	the course, incidence, and severity of neonatal jaundice was studied in 95 alaskan eskimo infants. breast-fed infants had higher bilirubin concentrations than bottle-fed babies. both groups experienced high bilirubin levels, similar to those previously reported in navajo and oriental infants but greater than those observed in whites and blacks. a marked capacity to inhibit hepatic glucuronyl transferase was observed in breast-milk specimens but only partly accounted for the bilirubin differences ...	1978	99026
interferon inducing activity of polyinosinic acid.	although poly(i) is generally considered to be inactive as an interferon inducer, we have found several authentic poly(i) preparations to be effective inducers. their interferon inducing ability varied considerably from one cell system to another. in human diploid fibroblasts, primed with interferon and superinduced by cycloheximide and actinomycin d, all active poly(i) samples proved nearly as effective in inducing interferon as poly(i).poly(c). in primary rabbit kidney cell cultures, the activ ...	1978	99486
natural distribution of squirrel monkey retrovirus proviral sequences in primate dnas.	3h-labelled 70s rna of squirrel monkey retrovirus (smrv) hybridized to a high degree (greater than 52%) to the dna of various tissues of two squirrel monkeys. hybridization of the same probe to dnas of other primates including new world monkeys (woolly monkey, capuchin, owl monkey), old world monkeys (rhesus, african green), apes (gibbon, chimpanzee), and human (a204 cells infected with mpmv) revealed no significant hybridization. analysis of the kinetics of hybridization indicated that smrv pro ...	1978	99487
development of leucocytozoon caulleryi in chick embryos infected by biting of culicoides arakawae through shell membrane.	chick embryos were infected with leucocytozoon caulleryi by biting of the midge, culicoides arakawae, through the shell membrane. schizonts of l. caulleryi were detected in the chorioallantoic membrane and most of the internal organs of embryos and of chicks after hatching. the development of schizonts was slower in embryos than in chickens. soluble antigens of l. caulleryi were demonstrated by the precipitation test in the allantoic fluid and blood from the embryos and chicks. no erythrocytic s ...	1978	99671
[cannabis].	cannabis produces a resin, the psychotropic effects of which are known since the high antiquity. it induces euphoria, a feeling of pleasant dreaminess. nevertheless, psychiatric disturbances such as psychomotor deficiency states or acute oniroïd states were described in heavy users countries. these psychiatric disorders put the accent on the starting or catalysing role of cannabis on the premorbid personality. the experimental studies of cannabis on the premorbid personality. the experimental st ...	1978	100034
uk-18892, a new aminoglycoside: an in vitro study.	uk-18892 is a new aminoglycoside antibiotic, a derivative of kanamycin a structurally related to amikacin. it was found to be active against a wide range of pathogenic bacteria, including many gentamicin-resistant strains. the spectrum and degree of activity of uk-18892 were similar to those of amikacin, and differences were relatively minor. uk-18892 was about twice as active as amikacin against gentamicin-susceptible strains of pseudomonas aeruginosa. both amikacin and uk-18892 were equally ac ...	1978	100050
cooperative binding of mn2+ and non-cooperative binding of mg2+ to beta-galactosidase (e. coli).		1978	100107
a rapid and convenient method for purification and isolation of chlorophyll-a from porphyra yezoensis.		1978	100111
beta-lactam antibiotics. ii. structure-activity relationships of 6-[alpha-(alpha'-ureido-acylamino) acylamino] penicillanic acids.	the influence on the structure-activity relationships (s.a.r.) of the stereochemistry and various alkyl, aryl, aralkyl and heterocyclic substituents at the two chiral centres in the dipeptide side-chain of a new series of penicillins was examined. in many cases the effects of these changes had a pronounced influence on the degree of activity against gram-positive and especially gram-negative bacteria. several compounds indicated that the size, shape and spatial disposition of a substituent were ...	1978	101499
purification and properties of a bacillus subtilis endonuclease specific for apurinic sites in dna.	an endonuclease which hydrolyzes depurinated dna has been purified from extracts of bacillus subtilis cells. the endonuclease is a monomeric protein and has a molecular weight of around 56,000. the enzyme is specific for apurinic sites in double-stranded dna, has a ph optimum at 8.0, and is slightly stimulated with 50 mm nacl but completely inhibited with 500 mm nacl. it requires no divalent cations and is insensitive to edta; it has no associated exonuclease. these properties are very similar t ...	1978	101548
isolation of staphylococcus aureus from sputum in cystic fibrosis.	the success in the isolation of staphylococcus aureus of different methods of sputum processing was investigated in 60 specimens collected from 14 patients with cystic fibrosis during a seven-month period. fifty specimens (83%) from 11 patients yielded staph. aureus by one or more methods. direct plating of purulent portions of sputum on to media designed for general use in respiratory infections gave unsatisfactory results (35% yield of staph. aureus). some increase in isolations was obtained w ...	1978	101553
[epidemiological study on beta hemolytic streptococci among healthy school children in toda city, saitama (author's transl)].		1978	101618
[prostatitis inhibiting fertility. gonococci superseded by other microbes].		1978	101822
topographic localisation of insulinogenic and insulinoprival areas in the hypothalamus.	electrical stimulation of hypothalamic areas through stereotaxically implanted electrodes were carried out in conscious male rhesus monkeys. there was a significant increase in immunoreactive insulin (iri) following laterla hypothalamus (lha) stimulation. an opposite response was obtained from ventromedial hypothalamus (vmh). thus, insulinogenic and insulinoprival responses were obtained from feeding and satiety, suggesting a significant role of insulin in the regulation of food intake.	1978	102526
purification and some properties of porcine brain mitochondrial monoamine oxidase b.		1978	103556
insulin counteraction of alpha-adrenergic effects on liver glycogen metabolism.	insulin counteracted the effects of a pure alpha-adrenergic agonist, phenylephrine, on hepatocyte glycogen synthase and phosphorylase. these results argue against current concepts of insulin increasing cytoplasmic ca2+ concentration.	1978	103580
oligosaccharides and polysaccharides specifically utilizable by bifidobacteria.		1978	103638
guinea pig immunoglobulin light chain isotypes. ii. the preferential expression of lambda chain-bearing anti-phenyltrimethylammonium antibodies is associated with restricted variable region expression, but not with any alteration in the proportion of lambda chain constant region isotypes, relative to normal immunoglobulins.	the inbred strain 13 guinea pig expresses at least three isotypes of immunoglobulin (ig) lambda chain. the proportion of these isotypes in normal ig can be estimated by isolating a constant (c) region cyanogen bromide peptide from lambda chains and quantitatively analyzing its component tryptic peptides. anti-phenyltrimethylammonium antibody, when analyzed in this way, was found to contain the same proportion of each lambda chain c region isotype as did normal ig. the specific antibody light (l) ...	1978	103730
characteristics of interhemispheric impulse conduction between prelunate gyri of the rhesus monkey.	cells of origin of the corpus callosum (callosal efferent neurons) in prelunate gyrus (area oa) of the rhesus monkey were studied using electrophysiological techniques. monkeys were chronically prepared and callosal efferent neurons were identified by their antidromic activation following electrical stimulation of the contralateral prelunate gyrus and/or the splenium of the corpus callosum. interhemispheric antidromic latencies ranged from 2.6--18.0 ms (median = 7.0 ms) while the conduction velo ...	1978	103739
a new sequence-specific endonuclease from anabaena cylindrica.		1978	103749
appearance of histochemically detectable ionic calcium in degenerating primary sensory neurons.	the effect of neonatal capsaicin treatment on the fine structure and localization of ionic calcium in sensory ganglion cells has been investigated in rats. neonatal capsaicin treatment resulted in the degeneration of certain type b sensory neurons. at the same time ionic calcium was demonstrated histochemically in the perikarya of numerous small-sized ganglion cells. the appearance of histochemically detectable ionic calcium in these cells in relation to the pharmacologically evoked degeneration ...	1978	104522
characterization of receptors mediating 5-hydroxytryptamine- and catecholamine-induced platelet aggregation, assessed by the actions of alpha- and beta-blockers, butyrophenones, 5-ht antagonists and chlorpromazine.	1 blood platelets from normal human volunteers were isolated and aggregated in vitro with 5-hydroxytryptamine (5-ht), noradrenaline (na), dopamine and n-dimethyldopamine (dmda). 2 the effects of 5-ht antagonists, alpha- and beta-adrenoceptor blocking agents, butyrophenones and chlorpromazine upon aggregation induced by the four amines were investigated. 3 only the the 5-ht antagonists, chlorpromazine and spiroperidol were potent inhibitors of 5-ht-induced aggregation, and only phentolamine was a ...	1978	26445
the effects of acridine orange on deoxyribonucleic acid in escherichia coli.	1. acridine orange inhibits growth of escherichia coli k12 when incubated at ph 7.9, but not at ph 7.4.2. at a non-permissive temperature for dna polymerase i, acridine orange inhibits growth of a temperature-sensitive strain and also increases the rate of elimination of the f'-lac plasmid. 3. dna isolated from cells treated with acridine orange under conditions that inhibit growth contains material of low molecular weight, which is absent from dna isolated from cells treated under conditions in ...	1978	27167
the ph-dependence of the non-specific esterase activity of carboxypeptidase a.	the hydrolysis of the following 6 esters by bovine pancreatic carboxypeptidase a (peptidyl-l-amino-acid hydrolase, ec 3.4.12.2) has been investigated over the range ph 5--10 at 25 degrees c, ionic strength 0.2: ch3co2chrco2h (r = c6h5 (ester 3), c6h5ch2 (ester 4), 4-no2c6h4co2chrco2h (r = c6h5 (ester 5), c6h5ch2 (ester 6), ch3(ch2)2 (ester 7)), ch3ch2co2ch(ch2c6h5)-co2h (ester 9). for each ester the ph dependence of kcat/km indicates that substrate binding is controlled by an acid of pkeh = 9.2 ...	1978	31187
solid phase indirect radioimmunoassays for the rapid diagnosis of sindbis virus antigen.	indirect radioimmunoassays have been developed for the rapid detection of sindbis virus. dilutions of sindbis virus from tissue culture fluids have been immobilized and allowed to react with rabbit anti-sindbis virus antibodies. the bound antibodies were assayed either by 125i-labelled anti-rabbit igg-antibodies or alternatively by addition of human complement and 125i-labelled anti-human c1q antibodies or 125i-labelled protein a.	1978	84855
equine markers genes. polymorphism for group-specific component (gc).	polymorphism of equine gc protein was demonstrated by immunofixation electrophoresis with a goat anti-human gc antibody. three different phenotypes, f, fs and s, were found. family data supported the genetic theory of two autosomal codominant alleles, gcf and gcs. both alleles occurred in standardbred, thoroughbred and arabian horses and in shetland ponies. a frequency of 0.23 for gcs in the american standardbred horse indicates the system should be useful for problems of identification and pare ...	1978	84540
fluorescence and electron microscope studies on the interaction between lysosomes of mammalian host-cells and toxoplasma gondii rh following treatment with cotrimoxazole [proceedings].		1978	84590
molybdenum independence of nitrogenase component synthesis in the non-heterocystous cyanobacterium plectonema.	the cyanobacterium plectonema boryanum (iu 594-utex 594) fixes n2 only in the absence of combined n and of o2. we induced nitrogenase by transfer to anaerobic n-free medium and studied the effect of mo starvation on nitrogenase activity and synthesis. activity was first detected within 3 h after transfer by the acetylene reduction assay in controls, increasing for at least 25 h. cells grown on nitrate and mo and then transferred to n-free, mo-free medium produced 8% of the control nitrogenase ac ...	1978	96092
pattern of phenazine pigment production by a strain of pseudomonas aeruginosa.	an atypical strain of pseudomonas aeruginosa capable of synthesizing three phenazine pigments was isolated. cultural conditions, under which the strain forms either chlororaphin, oxychlororaphin, or pyocyanine, are described. this broad spectrum of pigment production, as well as some other characteristics, sets this strain apart from previously described chlororaphin producers.	1978	96094
bacillus subtilis 168 genetic transformation mediated by outgrowing spores: necessity for cell contact.	transforming activity released in sequential genetic order during the first synchronous cycle of dna replication during outgrowth of spores of bacillus subtilis 168 was investigated. a transformation assay was used consisting of outgrowing spores as dna donors and multiply marked competent cells as recipients. dna synthesis inhibitors known to stop dna release were used during and subsequent to dna transfer to recipient cells. the released dna sedimented with the outgrowing cells after low-speed ...	1978	96105
food-borne diseases: a food service supervisor's dilemma.		1978	96375
[the appearance of penicillin resistant gonococci. clinical, genetic and epidemiologic problems].		1978	96408
chromosomal locations of mouse immunoglobulin genes.	the chromosomal locations of the structural genes coding for the constant portions of mouse heavy (h) and light chain immunoglobulins were studied by molecular hybridization techniques. complementary dna probes containing the constant-region sequences of kappa and lambdai light chain and alpha, gamma2b, and mu heavy chain mrnas were annealed to a large excess of dna from a series of eight mouse-human hybrid cell lines that are deficient for various mouse chromosomes. the lines were scored as pos ...	1978	96442
surface immunoglobulin of human lymphocytes.	using ferritin as surface marker, the localization of the surface immunoglobulin (ig) was studied on peripheral lymphocytes from normal human individuals and patients with macroglobulinaemia waldenström by scanning immunoelectron microscopy. normal igg-, igm-lymphocytes and pathological igm-lymphocytes were then compared with regard to their topographical differences. in all cells examined, igg- and igm-conjugated ferritin particles were detected all over the cell surface, but the distribution o ...	1978	96522
multivalvular vegetations in a patient with enterococcal endocarditis diagnosed by echocardiography.	a patient with enterococcal endocarditis of 11 months' duration is presented, and the role of surgery and echocardiography is reviewed. echocardiography revealed vegetations of the aortic and mitral valves. after appropriate antibiotic therapy the patient had successful aortic and mitral valve replacement with porcine heterografts. enterococcal endocarditis is increasing in frequency and is likely to infect young women of childbearing age, elderly men who have had genitourinary tract manipulatio ...	1978	96535
[effectiveness of antigens from various developmental stages of ascaris suum in the deomonstration of the migratory phase of experimental ascariasis in pigs].	tests of the efficiency of antigens prepared from different developmental stages of ascaris suum in indirect haemagglutination test in the course of proving the migration phase of experimental ascariasis in pigs show that the antigens prepared by ultrasound from the invasive larval stage of a. suum in comparison with antigens of sexually mature stages have higher serological activity. by using this antigen it is possible to prove specific antibodies in experimentally invaded pigs from 6 to 120 d ...	1978	96575
the fate of bacteriophage phie transfecting dna.		1978	96585
polarized light retinal photography of a monkey eye.		1978	96590
plasmid-determined resistance to hexachlorophene in pseudomonas aeruginosa.	plasmid-containing strains of pseudomonas aeruginosa were screened for resistance to disinfectants. two plasmids, pmg1 and pmg2, were found to determine hexachlorophene resistance.	1978	96729
antigenic variation and increase in pathogenicity in pseudomonas aeruginosa as a result of growth on glucose or n-hexadecane as sole carbon source.	when pseudomonas aeruginosa is grown on glucose as opposed to n-hexadecane as the sole carbon source, the antigenicity, virulence, and protein composition of the outer membrane are altered. the hydrocarbon-grown cells demonstrate a 3-log increase in virulence over the glucose-grown cells (in mice). there also appears to be an additional protein present in the outer membrane of the n-hexadecane-grown cells. this protein may contribute to the observed antigenic differences between the two cell typ ...	1978	96928
test for differentiation of m. tuberculosis and m. bovis from other mycobacteria.	a test is described for selective inhibition of mycobacterium tuberculosis and m. bovis isolates in fluid medium. the method employs rho-nitro-alpha-acetyl-amino-beta-hydroxy-propiophenone (nap) as an inhibitory agent for differentiation of mammalian tuberculosis strains from other mycobacteria.	1978	96930
[effect of valinomycin on mitotic activity and ciliary movement during embryonic development].	the k+ ionophore valinomycin very quickly arrests cleavage in sea urchin and mouse eggs at concentrations ranging between 10 and 3 micron. development of axolotl and xenopus eggs is not arrested before the blastula or gastrula stage. the motility of sea urchin sperm, blastulae and gastrulae is suppressed, within a few minutes, by 1-9 micron valinomycin.	1978	96956
[stimulation of pituitary lh and fsh secretion after immunoneutralization of endogenous substance p in the cycling rat].	in the cycling female rat, administration of substance p antisera performed at noon on the proestrous day provokes a significant increase in lh and fsh serum level, right before or after the preovulatory surges, but had no effect on its occurrence or magnitude. these results suggest that substance p has a normal physiological inhibitory role in gonadotropin regulation.	1978	96967
[interaction of epidermal growth factor with human fibroblasts in culture: an autoradiographic study at the ultrastructural level].	the potent mitogen epidermal growth factor (egf) binds to specific receptors on human fibroblasts. in the present study we have used a quantitative em autoradiographic approach to visualize the events involved in the binding process. when 125i-egf is incubated at 4 degrees c for 120 min, labeled egf primarily localizes to the plasma membrane of the fibroblast but when incubated at 37 degrees c for 120 min., over 2/3 of the labeled material is internalized by the cell. the internalized radioacit ...	1978	97010
[protective action on mice of acellular extracts from salmonella typhimurium].	acellular fractions obtained by saline extraction at 60 or at 100 degree c of salmonella typhimurium protect mice against an experimental infection with the homologous strain. after purification, these fractions which are complex, might be used for the development of a vaccine.	1978	97021
local cerebral energy metabolism: its relationships to local functional activity and blood flow.	the results of studies with the [14c] deoxyglucose technique unequivocally establish that local functional activity in cerebral tissues is, as in other tissues, closely coupled to the local rate of energy metabolism. stimulation of local functional activity increases the local rate of glucose utilization; reduced functional activity depresses it. local cerebral blood flow is normally distributed among the cerebral structures in almost exact proportion to their rates of glucose utilization and it ...	1978	97062
[suprachiasmatic nucleus, an hypothalamic regulation center of vital rhythmic functions].		1978	97067
lactase activity of microorganisms.	sixty-two strains of yeasts, molds and bacteria were screened for lactase (beta-d-galactosidase) activity. strains exhibiting the enzyme activity were evaluated for cell yield as well as enzyme units available per litre of the medium, per g cell dry weight and per mg protein of their cell-free extracts. the molds exhibited lowest enzyme activity but highest cell yields, bacteria produced lowest cell yield and maximum enzyme activity. cultures exhibiting very high activity among yeasts were sacch ...	1978	97187
[vitamin b 6 biosynthesis in bacillus subtilis].	1) a vitamin-b6-producing mutant, ba 1, was selected by treatment of bacillus subtilis with n-methyl-n'-nitro-n-nitrosoguanidine. using gradient plates supplemented with the vitamin b6 antagonist isonicotinohydrazide, three mutants of ba 1 were isolated, which excrete 2-5 mg of vitamin b6/l of growth medium. 2) mutation of the three vitamin-b6-producing strains ba 1, ba 11 and l 71 led to the isolation of 49 vitamin-b6 deficient mutants. all mutants are able to grow with pyridoxine, pyridoxal, p ...	1978	97199