Publications

isolation of yersinia enterocolitica from danish swine and dogs.	seventeen strains of yersinia enterocolitica were isolated on examination of the caecal contents from 100 bacon pigs at slaughter. in another material consisting of 222 pigs with various diseases, the bacterium was found in 12 cases. three out of 40 dogs were positive for the bacterium. seven of the porcine and one of the canine strains belonged to serotype o 3, which is a human pathogen.	1976	970137
[sugar composition of crude lipopolysaccharides isolated from yersinia enterocolitica 0-3, 0-5b and 0-9].		1976	1034033
antibodies to yersinia enterocolitica in thyroid disease.	the prevalence of elevated antibody titers against yersinia enterocolitica was studied in normal subjects, patients with a variety of nonthyroidal illnesses, and patients with thyroid disease. in contrast to the low prevalence of antibodies in controls (less than 8%), 48 of 67 patients (75%) with a variety of thyroid disorders had titers greater than 1:8. antibodies were found in 24 of 36 patients with graves' disease, five of six with autonomous adenoma, seven of seven with hashimoto's thyroidi ...	1976	1036668
[drug sensitivity of yersinia enterocolitica and yersinia pseudotuberculosis].	drug-sensitivity of 70 strains of y. enterocolitica and 24 of y. pseudotuberculosis including reference strains and isolates from men or animals were determined by the agar plate-dilution method. all the strains of y. enterocolitica were relatively resistant to penicillins and cephalosporins, while all of y. pseudotuberculosis were sensitive to both of the agents. most of the strains of both species excluding 13 resistant ones were sensitive to streptomycin. the resistant strains, however, were ...	1976	1047115
yersinia enterocolitica septicemia with septic arthritis.	we report a case of yersinia enterocolitica septicemia with septic arthritis. gentamicin administration controlled the septicemia but failed to eradicate the organisms in the joint, in spite of a synovial fluid level four times its minimal inhibitory concentration after four days of therapy. development of azotemia necessitated change of antibiotic therapy to chloramphenicol, which eradicated the infection. while y enterocolitica infection in the united states is uncommon, it must be added to th ...	1976	984993
[experimental infection of axenic mice by "yersinia enterocolitica" (author's transl)].	although most of yersinia enterocolitica strains isolated from man have no pathogenicity for laboratory animals, it has been demonstrated that some strains are pathogenic for conventional mice and that most of the strains are probably pathogenic for nude mice. the authors report the results of the infection of germ-free mice with a strain of y. enterocolitica which is non pathogenic for holoxenic mice. it appears that c3h/he mice are sensitive to the infection by gavage or aerogenic and peritone ...	1976	970831
[influence of substances that change the serotonin level of the brain on the analgesic effect of promedol in rats].	in tests with determination of pain reaction in rats registered by their squeak and arising in reponse to a single electric irritation of the tail evidence was obtained to the effect that substances both lowering the serotonin content in the brain (p-chlorphenylalanine, reserpine) and raising it (5-oxytryptophan, pargilin) cause a fall of the threshold, viz. 5-oxytryptophan and pargilin display antagonism to the analgetic effect of trimeperidine hydrochloride, whereas p-chlorphenylalanine, and i ...	1976	1082823
treatment of spontaneous leukemia in akr mice with chemotherapy, immunotherapy, or interferon.	akr mice are genetically destined to develop gross (rna) virus-induced lymphatic leukemia. leukemic akr mice treated with combination vincristine, cyclophosphamide (cytoxan), and 1-(2-chloroethyl)-3-(trans-4-methylcyclohexyl)-1-nitrosourea sustained a 180% increase of life-span. combination chemotherapy plus immunization with neuraminidase-treated allogeneic (gross virus-induced) g2g leukemic cells intradermally resulted in 35% of animals surviving beyond 150 days without evidence of the disease ...	1976	1082796
[roentgenologic picture of infections caused by yersinia enterocolitica (author's transl)].		1976	974835
hapten specific ige antibody responses in mice. v. differential resistance of ige and igg b lymphocytes to x-irradiation.	the studies presented in this paper were undertaken to determine whether ige- and igg-producing murine b lymphocytes could be distinguished by differential resistance to x-irradiation in vivo. sensitivity or resistance of b lymphocytes to various doses of x-irradiation was monitored by measuring the production by irradiated cells of hapten-specific igg and ige antibody. the results indicate that both primed and unprimed igg b lymphocytes are less radioresistant than corresponding ige b lymphocyt ...	1976	1087320
yersinia enterocolitica ileocolitis findings observed on barium examination.		1976	938838
autoimmune thyroiditis in t-cell-depleted rats.		1976	1087417
[yersinia arthritis (author's transl)].	yersinia arthritis is an acute oligo- or, more rarely, polyarthritis. it occurs after pyrexic diarrhoea of several days, often associated with right-sided lower abdominal pain. the disease is caused by yersinia enterocolitica and four such cases, confirmed serologically in three, are described. in one case fluid from the knee-joint was antibody-positive. it was not possible to culture the causative organism, probably because all patients had previously been treated with an antibiotic. rheumatic ...	1976	976116
yersinia enterocolitica infection in a 4-month-old infant associated with infection in household dogs.		1976	978324
yersinia enterocolitica infection in patients with acute surgical abdominal disease. a prospective study.	the rate of yersiniosis in patients with acute abdominal disease was studied in a 16-month prospective investigation in 1972-1973 of 205 acutely ill patients referred to a surgical clinic of a copenhagen city hospital with complaints of abdominal pain suggestive of appendicitis. yersinia enterocolitica, biotype 4, was isolated from 11 patients (5.4%), 8 of whom were children. yersinia was grown from faeces in 8 cases and from appendix of all 9 patients operated upon. rising or falling agglutinin ...	1976	788144
homologous inhibitors from potato tubers of serine endopeptidases and metallocarboxypeptidases.	a potent polypeptide inhibitor of chymotrypsin has been purified from russett burbank potatoes. the inhibitor has no effect on bovine carboxypeptidases a or b but exhibits homology with a carboxypeptidase inhibitor that is also present in potato tubers. the chymotrypsin inhibitor has a molecular weight of approximately 5400 as estimated by gel filtration, amino acid analysis, and titration with chymotrypsin. the polypeptide chain consists of 49 amino acid residues, of which six are half-cystine, ...	1976	1064864
[chronic obstructive bronchitis: definitions, risk factors and prevention (author's transl)].	chronic obstructive bronchitis is defined as persistent diffuse airways obstruction frequently associated with chronic expectoration. this disease is particularly disabling and its medico-social burden implies that measures be taken. risk factors of chronic obstructive bronchitis can be classified according to their presently known importance: tobacco, professional exposure, air pollution, viral and bacterial respiratory infections, poor socio-economic and cultural conditions, upper and lower ai ...	1976	1005858
[septicemia caused by yersinia enterocolitica. apropos of a case with septic cerebellar metastasis].		1976	1007802
studies on yersinia enterocolitica. ii. relationship between detection from swine and seasonal incidence, and regional distribution of the organism.		1976	985980
[yersinia enterocolitica. i. isolation of antigenic fractions from y. enterocolitica].		1976	987277
facial abscess due to yersinia enterocolitica.		1976	998562
analytical subfractionation of microsomal fractions from the livers of control and gunn-strain rats.		1976	1001660
identification of blood groups and isoenzymic phenotypes from blood stains, heart blood and nervous tissues after transfusion.	a man aged 42 years died from a hemorrhage resulting from stab wounds in his neck, chest and abdomen. the mn blood group and pgm1 phenotype of the victim's heart blood were inconsistent with those of the blood stains around the victim. the victim was transfused with 4000 ml of blood during the 9 hours before his death. because pgm1 phenotypes obtained from blood stains at the scene of the crime and from the weapon corresponded with those from the victim's dental pulp, peripheral nerve and bone m ...	1976	1002077
[experiments to reproduce yersinia enterocolitica type 9 infection in guinea pigs].		1976	1025844
[pathohistological changes in guinea pigs experimentally infected with yersinia enterocolitica serotype 9].	a total of forty-five guinea pigs were injected subcutaneously with 0.1 cu cm carboneum tetracholoratum each and were infected with yersinia enterocolitica serotype 9. part of the animals (31) were treated at the 24th hour following infection with omnopon (a morphine preparation). all infected guinea pigs developed an infectious process manifested by dystrophic and inflammatory changes in the liver, intestine, spleen, lymph nodes and lungs. those treated with omnopon manifested a more acute infe ...	1976	1025846
biological activities of endotoxins from yersinia enterocolitica.	the chemical properties and the general biological activities of lipopolysaccharide (lps) and boivin-type endotoxin obtained respectively by phenol-water and trichloroacetic acid extraction from yersinia enterocolitica serotypes o3 and o9 were studied. the yield of lps from the o9 strain was about 10% of the o3 strain possibly because of the lower solubility of o9-lps in aqueous phase. however, the chemical composition of o9-lps was similar to that of o3-lps in the proportions of reducing sugar, ...	1976	978837
[joint manifestations of yersinia enterocolitica infections].	different recent studies, notably scandinavian studies, have described a "rheumatism" caused by yersinia enterocolitica infection. the picture usually seen is that of a subacute, febrile oligoarthritis predominantly in the lower limbs, associated with diarrhoea and hyperleucocytosis, polynucleosis, and a marked increase in the sedimentation rate. benign carditis may also be associated. the diagnosis rests on the discovery of the organism by coproculture and on serodiagnosis. evolution is favoura ...	1976	981921
[polyarthritis following yersinia enterocolitica infection].		1976	981922
recovery of yersinia enterocolitica from streams and lakes of california.	stream and lake water from the mammoth lakes region of california was sampled for yersinia enterocolitica. from 10 of the 34 sites examined, organisms were isolated that were biochemically identified as y. enterocolitica. only one of the ten strains could be serologically confirmed. this strain was identified as y. enterocolitica serotype 16. although an outbreak of enteritis in the area prompted this study, no correlation with gastrointestinal disease could be established since the majority of ...	1976	984815
yersinia enterocolitica infections in children.		1976	932907
examination of the envelope antigen k1 in yersinia enterocolitica which was identified as fimbriae.	the envelope antigen k1 found in the majority of yersinia enterocolica (y. ent.) strains belonging to the o group 10 as described by wauters, was re-examined under the electron microscope, and identified as being fimbriae. these fimbriae envelop the bacterial cell with a dense fringe. single filaments show a width of 2.5 to 1.7 nm whilst their length is variable, often many times the size of the bacterial cell. fimbriated y. ent. cultures do not form pellicle, and the haemagglutination test is n ...	1976	936830
[a case of acute terminal ileitis due to yersinia enterocolitica infection (author's transl)].		1976	943626
isolation of yersinia enterocolitica from a dog with chronic enteritis: a case report.		1976	952255
properties of pgc1, a lac plasmid orginating in yersinia enterocolitica 842.	pgc1, a self-transmissible lac plasmid that originated in yersinia enterocolitica 842, is described. this plasmid is freely transmissible between strains of y. enterocolitica and from such strains to strains of escherichia coli. the plasmid can also be transferref among g. coli strains and back to y. enterocolitica, although at a greatly reduced frequency. pgc1 has a molecular weight of about 33.0 x 10(6), has a base composition of about 44 mol% guanine plus cytosine, and is fi-.	1976	956120
[yersinia enterocolitica in acute appendicitis, lymphadenitis mesenterialis and regional enteritis (author's transl)].	in 895 patients operated on for acute appendicitis we found yersinia enterocolitica in 41 cases. another two cases were detected in postoperative serological examinations. lymphadenitis mesenterialis was present in 17 cases during operation. once we detected a regional enteritis. histological examination of the appendix revealed a purulent inflammation in 21 cases and a phlegmonous-gangrenous inflammation in 4 cases. the other 18 patients suffered from oxyuriasis, coprostasis or scars of the app ...	1976	961157
yersinia enterocolitica isolates from humans in california, 1968-1975.	this paper reports on the serological and biochemical characteristics of 24 human isolates of yersinia enterocolitica submitted to the california department of health from 1968 through 1975. nine different serotypes were represented. the majority of strains were serotype o:8 (six strains) and serotype o:5 (five strains). sources of the isolates included feces (12 cases), blood (3), sputum or throat (3), bile or bowel drainage (2), wounds (2), breast abscess (1), and skin abscess (1). clinical hi ...	1976	965477
[acute enterocolitis caused by yersinia enterocolitica].		1976	968263
indirect immunofluorescence staining of human thyroid by antibodies occurring in yersinia enterocolitica infections.	in the diagnostic routine for tissue antibodies, using indirect immunofluorescence on cryostat sections of human thyrotoxic thyroid, rat stomach and kidney, ninety-six out of 48,388 sera showed a marginal staining of the membrane region of thyroid epithelial cells but no other reaction. twenty-six of these sera were from patients with acute yersinia enterocolitica serotype 3 infection but without signs of thyroid disease. fifty of sixty-three sera with agglutinins against y. enterocolitica serot ...	1976	780011
[acute polyarthritis in yersinia enterocolitica infection. 4 cases in belgium].	four cases in acute polyarthritis observed in belgium, secondary to infection with yersinia enterocolitica are reported. apart from in finland, where the frequency of yersinian rheumatism appears to be equal to that of bouillaud's disease, these published cases are exceptional. this might appear surprising when it is realized that yersinia is endemic in western europe and in other parts of the world and that alimentary manifestations are not rare and are now well known. this polyarthritis presen ...	1976	817386
[phospholipase activity of yersinia enterocolitica strains (author's transl)].		1976	819109
enzyme-linked immunosorbent assay (elisa) for titration of antibodies against brucella abortus and yersinia enterocolitica.	an enzyme linked immunosorbent assay (elisa) using phenolwater extracted lipopolysaccarides as antigen was used for detection and quantitation of antibodies against brucella and yersinia bacteria in rabbit antisera. elisa was found to be from ten to hundred-fold more sensitive than the commonly used tube agglutination assay (widal). in addition, both direct and inhibition assays using elisa revealed antigenic differences between brucella abortus and yersinia enterocolitica o-group v, previously ...	1976	826112
pseudotuberculosis (yersinia enterocolitica) in the owl monkey (aotus trivirgatus).	pseudotuberculosis caused by yersinia enterocolitica was observed as an enzootic disease of the owl monkey (aotus trivirgatus). a description is given of the natural disease and its successful reproduction in owl monkeys. the disease was characterized by purulent and necrotizing enteritis, hepatitis, and splenitis. large colonies of the causative organism were consistently associated with the lesions. although pseudotuberculosis has been reported in other monkeys, the disease in the authors' pri ...	1976	828225
letter: incidence of yersinia enterocolitica and y. pseudotuberculosis infections in canada; 1975 semiannual report.		1976	766935
effect of epinephrine on the oxidative desaturation of fatty acids in the rat.	the effect of epinephrine on the oxidative desaturation of fatty acids by liver microsomal preparations of rats has been studied. administration of epinephrine (1 mg/kg body weight) produced a significant decrease in desaturation of [l-14c]=linoleic acid to gamma-linolenic acid and of [l-14c]alpha-linolenic acid to actadeca-6,9,12,15-tetraenoic acid 12 hr after the infection. lower doses produced a lesser effect on the delta6-desaturation activity. epinephrine administration modified the v max o ...	1976	186549
carcinogenic activity of quinoline on rat liver.	the effects of prolonged p.o. administration of quinoline or 2-chloroquinoline on rat liver were examined histologically. hepatocellular carcinomas and hemangioendotheliomas were observed in the livers of rats fed a basal diet containing 0.05, 0.10, or 0.25% quinoline for about 16 to 40 weeks. however, no neoplastic changes were seen in the livers of rats fed a basal diet containing 0.05, 0.10, or 0.25% 2-chloroquinoline for 40 weeks. in groups that received low concentrations of quinoline, the ...	1976	177193
steroid-binding proteins in carcinoma of the human male breast.	receptor sites for a group of four steroid hormones were estimated by competitive binding assay of a biopsy specimen of carcinoma from a male breast. the results indicate that the tissue contained a significant number of binding sites for 17beta estradiol, and probably for dihydrotestosterone and progesterone, but not for testosterone. these preliminary data suggest that, as in the female, certain mammary carcinomas in the male may be under the influence of steroid hormones. correlation of such ...	1976	176884
uridine--cytidine kinase from foetal and adult rat liver. purification and study of some properties.	partial purification of uridine--cytidine kinase (ec 2.7.1.48) from foetal rat liver by chromatography on deae-cellulose gives two active fractions. the first in order of elution was identified as a form specific for foetal liver. it was purified 300-fold. the second fraction was common to foetal, and adult rat liver and spleen and was purified 20-fold. the foetal fraction of the enzyme was found to be heat-sensitive and protected against inactivation by po34- anions. the two isolated forms have ...	1976	186262
transfer of parental immunity to infectious laryngotracheitis in chicks.	the transfer of parental immunity to infectious laryngotracheitis was appraised by measuring serum antibody levels in 150 chicks from the day of hatch up to five weeks. the breeder flock which had received primary vaccination at eight weeks and a booster at 20 weeks transferred high antibody levels which fell markedly within two weeks and remained constant thereafter. chicks whose parents were vaccinated at 20 weeks only, had low antibody levels throughout. these low levels, in either group of c ...	1976	187298
interrelationships between the central nervous system and patterns of adrenocorticotropic secretion following acute exposure to severe environmental conditions.		1976	187557
the application of rapid kinetic techniques to the transport of thymidine and 3-o-methylglucose into mammalian cells in suspension culture.	techniques are described by which the transport of nutrients into mammalian cells in suspension can be measured at intervals of 1.5 seconds. by application of these techniques, the existence of a saturable (km = 85 mum), non-concentrative, transport system for thymidine was demonstrated in novikoff rat hepatoma cells depleted of atp. at concentrations of thymidine less than the km, this system operated at velocities sufficient to nearly completely equilibrate intra- and extra-cellular thymidine ...	1976	188833
regulation of carbohydrate permeases and adenylate cyclase in escherichia coli. studies with mutant strains in which enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system is thermolabile.	carbohydrate uptake and cyclic adenosine 3':5'-monophosphate (cyclic amp) synthesis were studied employing mutant strains of escherichia coli in which enzyme i of the phosphoenolpyruvate:sugar phosphotransferase system was heat-labile. partial loss of enzyme i activity, which resulted from incubation of cells at the nonpermissive temperature, depressed the rate and extent of methyl alpha-glucoside uptake. temperature inactivation of enzyme i also rendered cyclic amp synthesis and the uptake of s ...	1976	184083
cell coat in tumor cells -- effects of trypsin and edta: a biochemical and morphological study.	the effects of trypsin and edta on the cell coat of ascites tumor cells were studied by means of biochemical and electron microscopy techniques. edta seems to release, by chelation of the ca2+-bridges, an outer layer of glycoproteins of presumably exogenous origin. on the contrary, trypsin produces a deeper enzymic cleavage which appears to affect the structural integrity of the bilayered cell membrane. the significance of the cell leakage in tumor cells and the effect of edta on the modificatio ...	1976	185564
ultrastructure of lipopolysaccharides of yersinia enterocolitica, salmonella typhimurium and escherichia coli.	the fine structure of isolated lipopolysaccharides (lps) from the rough and smooth form of an yersinia enterocolitica strain (ye 75 r/ye 75 s) and from smooth forms of salmonella typhimurium (s 1010) and escherichia coli (essen) were examined electron-microscopically by negative staining. partial denaturation of lps in tris-buffer with acid and/or polymyxin b treatment revealed a common structure of strandlike lps. electron-microscopically, lps-strands were found to consist of two identical sub- ...	1976	185850
effect of cerebral injury on cerebrospinal fluid cyclic amp concentration.	cerbrospinal fluid (csf) cyclic adenosine-3', 5'-monophosphate (camp) was measured in rabbits after experimental brain injury as well as in patients with cerebral contusion and cerebral concussion. in rabbits a marked elevation lasting for two weeks was observed. from the third week onwards after the injury the csf camp concentration was lower than the basal level before the injury. dexamethasone partly inhibited the elevation. ethanol treatment decreased the csf camp values. in man, the csf cam ...	1976	186266
[changes in the level of acth in the fetal hypophysis. a study in the rat toward the end of gestation].	the isolated adrenal cell method for bioassay of acth was employed in order to determine the acth content of the hypophysis of the rat foetus, in late pregnancy. the acth concentration decreases between 17 days 8 h and 17 days 15 h, then it increases regularly until the term. this evolution is correlated with the change in the fluorescence intensity of the corticotrophs and with the modification of the adrenocortical activity.	1976	177226
the role of serum nonsuppressible insulin-like activity (nsila) in compensatory renal growth.	the nonsuppressible insulin-like activity (nsila) of serum is defined as the insulin-like activity measured in insulin bioassays that is not suppressed by addition of insulin antiserum. the major part of serum nsila is attributable to a 90,000 mol wt trace protein which has been recently purified. this study was designed to evaluate the role of serum nsila in compensatory renal growth (crg).	1976	177337
coxsackievirus and adenovirus infection. association with acute febrile and juvenile rheumatoid arthritis.	the prearthritic manifestations of juvenile rheumatoid arthritis in a 16-year-old boy were associated with a rise in coxsackievirus b3 and a9 neutralizing antibody titers from 1:16 to larger than or equal to 1:512, and 1:64 to 1:512, respectively. recurrent polyarthritis followed and has persisted for three years. adenovirus 7 was isolated from the pericardial fluid of a 9-year-old girl in whom juvenile rheumatoid arthritis then developed. of 11 patients with acute, nonspecific, febrile arthriti ...	1976	177792
acidic steroid metabolites: evidence for the excretion of c-21-carboxylic acid metabolites of progesterone in rabbit urine.		1976	177811
investigations on the turnover of adrenocortical mitochondria. iv. a stereological study of the effect of chronic treatment with acth on the size and number of rat zona reticularis mitochondria.	the effects of chronic administration of of acth (up to 36 consecutive days) on the mitochondria of the zona reticularis of the rat adrenal cortex were investigated by stereologic techniques. it was found that acth induces two phases of hypertrophy of mitochondria alternating with two proliferative stages, which are associated with a significant decrease in the average volume of the organelles. it is suggested that, as in the zona fasciculata, acth controls the processes of growth and division o ...	1976	178447
generation of superoxide anion and chemiluminescence by human monocytes during phagocytosis and on contact with surface-bound immunoglobulin g.	extent of o-2-release and chemiluminescence, attributed to singlet oxygen, has been compared in human monocytes and neutrophils during phagocytosis, stimulation by the surface-active agent phorbol myristate acetate, or contact with aggregated igg in a model of immune complex disease. monocytes generated o-2-and chemiluminescence with each of the three stimuli, although values were significantly less than those of neutrophils from the same individuals. lymphocytes had no significant activity in e ...	1976	178824
nad+-malic enzyme. regulatory properties of the enzyme from ascaris suum.	the regulatory properties of the nad-dependent malic enzyme from the mitochondria of ascaris suum have been studied. the malate saturation curve exhibits sigmoidicity and the degree of this sigmoidicity increases as the ph is increased. fumarate was the only compound tested that stimulated the enzyme activity, whereas oxalacetate was the most powerful inhibitor. activation by low levels of fumarate was found to be competitive with malate. it is proposed that this stimulation has physiological si ...	1976	180002
herpes simplex virus specified deoxypyrimidine kinase and the uptake of exogenous nucleosides by infected cells.	herpes simplex virus can confer to thymidine kinaseless cells the ability to incorporate exogenously supplied thymidine into acid precipitable material. however no incorporation of exogenously supplied deoxycytidine into acid precipitable material can be detected after infection of deoxycytidine kinaseless cells by herpes simplex virus. this failure to incorporate exogenous deoxycytidine is not due to the failure of the deoxycytidine phosphorylating activity of the virus induced deoxycytidine ki ...	1976	180246
serum testosterone and dihydrotestosterone in patients with trophoblastic disease.	serum testosterone (t) and dihydrotestosterone (dht) were measured by radioimmunoassay in 14 patients with unaborted hydatidiform mole and in 16 patients with normal pregnancy of similar gestational age. serum human chorionic gonadotropin (hcg) was measured by the radioreceptor assay in patients with hydatidiform mole. serum t ranged from 0.27 to 5.39 ng/ml with a mean +/- se of 2.21 +/- 0.45 ng/ml in patients with hydatidiform mole mole and from 0.20 to 2.40 ng/ml with a mean +/- se of 0.80 +/- ...	1976	180465
regulation of pyruvate dehydrogenase in rat heart. mechanism of regulation of proportions of dephosphorylated and phosphorylated enzyme by oxidation of fatty acids and ketone bodies and of effects of diabetes: role of coenzyme a, acetyl-coenzyme a and reduced and oxidized nicotinamide-adenine dinucleotide.	the proportion of active (dephosphorylated) pyruvate dehydrogenase in perfused rat heart was decreased by alloxan-diabetes or by perfusion with media containing acetate, n-octanoate or palmitate. the total activity of the dehydrogenase was unchanged. 2. pyruvate (5 or 25mm) or dichloroacetate (1mm) increased the proportion of active (dephosphorylated) pyruvate dehydrogenase in perfused rat heart, presumably by inhibiting the pyruvate dehydrogenase kinase reaction. alloxan-diabetes markedly decre ...	1976	180974
on the utilization of l-glutamine by glutamate dehydrogenase.		1976	180990
inhibition of estrogen-receptor-dna interaction by intercalating drugs.	ethidium bromide, an intercalating drug, was shown to inhibit the in vitro dna binding of the uterine estradiol-receptor complex. the inhibition was reversible, dose dependent, complete for total saturation of dna intercalating sites by the dye, and proportional to the extent of intercalated drug. the binding of the receptor to phosphocellulose and poly(adenylic acid)-cellulose was not decreased by this drug. similar inhibition was also obtained with 9-hydroxyellipticine. denatured dna was more ...	1976	182199
testosterone-binding protein in reproductive tracts of fetal rats.	testosterone-binding proteins may mediate the induction of wolffian duct differentiation by testicular testosterone. the presence of such protein(s) was sought in reproductive tracts of 14.5-21.5-day-old fetal rats. supernatant fractions (127,000 x g) were equilibrated with [3h]t) +/- radioinert testosterone in tris - hcl:edta buffer, ph 7.4, (approximately 0.1 mg protein/0.5 ml) at 4 c for 16 hours. bound and free (3h)t were separated by charcoaldextran adsorption or sephadex g-100 gel filtrati ...	1976	182453
in vitro behavior of human intestinal mucosa. the influence of acetyl choline on ion transport.	the possibility that the autonomic nervous system may influence the function of intestinal mucosa was investigated by assessing the effect of acetyl choline on ion transport in human intestine. isolated pieces of stripped ileal mucosa were mounted in perspex flux-chambers and bathed in isotonic glucose ringer's solution. acetyl choline caused a rise in mean potential difference (8.8-12.3 mv, p less than 0.002) and short circuit current (287.7-417.2 mua-cm-2, p less than 0.01) (n = 12), observabl ...	1976	182722
experimental evaluation of paracetamol antidotes.		1976	193746
[the effect of multiple injections of acth (alone and combined with sodium ribonucleinate) on incorporation of p32-orthophosphate into the mitochondrial rna of the liver, spleen and heart of white rats].		1976	176651
secretion of macrophage neutral proteinase is enhanced by colchicine.	we have studied the effect of colchicine and related compounds on secretion of enzymes by thioglycollated-elicited mouse peritoneal macrophages in culture. colchicine stimulated secretion of inducible neutral proteinase activities of elastase (ec 3.4.21.11), collagenase (ec 3.4.24.3), gelatinase (pepsin b; ec 3.4.23.2), and azocaseinase 2- to 6-fold for a period of several days, but inhibited the production and release of lysozyme (mucopeptide n-acetylmuramoylhydrolase; ec 3.2.1.17), a noninduci ...	1976	176659
cellular fatty acids during fowlpox virus infection of three different host systems.		1976	176806
infectivity of visna virus dna.		1976	176812
heart functional responses to pressure overload in exercised and sedentary rats.	female rats that had been subjected to a moderate treadmill running program were compared with sedentary animals on the basis of heart weight, selected biochemical measurements, and heart function. exercised animals maintained normal growth rate, and cardiac hypertrophy was not present. left ventricular rna, dna, and cytochrome c levels were unchanged. heart functional measurements obtained in situ were similar in sedentary and exercised animals under control conditions. when subjected to sustai ...	1976	175664
[bdellovibrio bacteriovorus as a factor in the self-purification of river water].		1976	134929
[on the antibacterial activity, absorption, excretion, distribution and metabolism of spectinomycin (author's transl)].		1976	135101
bulbourethral gland infections in mice associated with staphylococcus aureus.		1976	135128
liver plasma membrane enzyme activities following glutaraldehyde fixation.	the wachstein-meisel atpase histochemical method has been previously used to demonstrate the ultrastructural localization of this enzyme in both whole liver and isolated plasma membranes following fixation in glutaraldehyde. in the present study biochemical assay, of liver plasma membrane enzymes following fixation in cold 2.5% glutaraldehyde showed that approximately 40% of mg2+-atpase, but only 4% of (na+-k+)-atpase activity remained in membranes from either control or anit-treated rats. in ad ...	1976	135243
[tuberculosis in domestic animals and its relationship with human tuberculosis].		1976	135254
studies of the histochemistry, ultrastructure, motor innervation, and regeneration of mammalian intrafusal muscle fibres.		1976	137430
[is there a connection between infection with yersinia enterocolitica and regional enteritis? (preliminary communication) (author's transl)].	after a brief description of the micro-biological, pathological, anatomical and clinical picture of infections with yersinia enteroclitica, attention is drawn to the striking radiological similarity between three patients with yersinia infection and regional enteritis (crohn's disease). whilst the radiological findings due to yersinia infection usually resemble the group of so-called non-sclerosing ileitis (golden) they occasionally differ from this group and resemble the findings in crohn's dis ...	1976	137848
differentiaton of neuropharmacological actions of apomorphine and d-amphetamine.	the dopaminergic agonists apomorphine and d-amphetamine elicit hyperthermic, hyperkinetic and stereotypic responses in the rabbit. the present investigation compares the influence exerted by various serotonergic antagonists upon these activities. apomorphine-induced hyperthemia was antagonized by p-chlorophenylalanine (pcpa), cyproheptadine and cinanserin and was restored in pcpa-pretreated rabbits by regeneration of central serotonin levels, d-amphetamine-induced hyperthermia was reduced by pcp ...	1976	139615
binding of cibacron blue f3ga to proteins containing the dinucleotide fold.	a simple, convenient, and sensitive spectrophotometric procedure is described for quantitative measurement of nucleoside phosphate binding sites constructed by the dinucleotide fold. the procedure involves difference spectral titration of such enzymes with the dye cibacron blue f3ga in a spectral region remote from the intrinsic absorbance of proteins or natural ligands. the titration curves can be analyzed to determine the affinity of nucleoside phosphate binding sites for both the dye and the ...	1976	174104
ischemia-induced alterations in myocardial (na+ + k+)-atpase and cardiac glycoside binding.	the effects of ischemia on the canine myocardial (na+ + k+)-atpase complex were examined in terms of alterations in cardiac glycoside binding and enzymatic activity. ability of the myocardial cell to bind tritiated ouabain in vivo was assessed after 1, 2, and 6 h of coronary occlusion followed by 45 min of reperfusion, and correlated with measurements of in vitro (na+ + k+)-atpase activity and in vitro [3h]ouabain binding after similar periods of ischemia. regional blood flow alterations during ...	1976	130383
[spontaneous peripheral proteolysis/1st communication: method and results of clinical examinations (author's transl)].	with a modificated astrup-fibrin plate-method also an inhibition of proteolysis can be registrated. in various medical areas a spontaneous peripheral proteolysis had been found, especially so in chronical bacterial infections.	1976	132940
the effect of increased brain gaba produced by amino-oxyacetic acid on arousal in rats.	previous work has reported behavioral arousal in the rat to be inversely related to cortical gaba production. therefore the effects of an increase in brain gaba levels, induced by amino-oxyacetic acid, on measures of behavioural arousal such as rearing and ambulation were examined. the increase in gaba was immediately associated with decreased rearing, however the behaviour was later indistinguishable from control values while the levels of brain gaba remained raised. it was suggested that the r ...	1976	134388
allergic reaction to allopurinol with cross-reactivity to oxypurinol.	a 25-year-old white man with gout and nephropathy and with a previous reaction to allopurinol was given a trial dose of oxypurinol. he developed malaise, a generalized erythematous reaction with edema, pruritus, and emesis; this was clinically identical to the reaction he experienced with allopurinol. when the patient's lymphocytes were exposed in vitro to oxypurinol and allopurinol, increased dna synthesis was observed, suggesting an immunologic basis for the reaction. this patient indicates th ...	1976	134655
[study of the threshold dose of penicillin which induces an epileptogenic focus during ontogenesis in the rabbit].	a local application on the cortex surface of a very small drop of ringer solution containing penicillin was performed to establish the threshold dose required to elicit and epileptogenic focus and consequently the occuring latency of it. threshold doses are small (20 - 60 international units) and show a significant decrease during the maturation of the c.n.s. on the other hand latencies, whatever the animal's age, decrease fairly. the results are confronted to the various supposed modes of actio ...	1976	134784
[antigenic analysis and immunological studies of the uterotropic bacterial strains sh6 and 01 isolated from aborted cows].	the uterotropic strains sh6 and o1 were studied immunoelectrophoretically to establish their antigenic relationship. the more readily diffusing component of the o-antigenic fraction of the strains proved immunologically identical with lpa of the r brucella organisms, while the slower component showed common determinants with the o-antigenic fraction of yersinia pseudotuberculosis. immunodiffusion revealed that the o-antigenic fraction of the o1 strain and lpa of the s brucella organisms contain ...	1976	60821
[antigenic and serologic properties of yersinia enterocolitica].		1976	62475
worldwide spread of infections with yersinia enterocolitica.		1976	63181
a serial study of pregnancy proteins in primigravidae.	the plasma concentrations from four 'pregnancy proteins' and three steroid hormones have been measured throughout pregnancy in 15 primigravidae. two of the proteins, human placental lactogen (hpl) and pregnancy-specific beta1-glycoprotein (psbetag), are specific for pregnancy and correlate well with the stage of gestation. it is suggested that measurement of psbetag may be useful in assessing feto-placental wellbeing. neither of the pregnancy-associated proteins, steriod-binding beta-globulin (s ...	1976	57799
antigenic relationship between morganella morganii and yersinia enterocolitica.	two new o antigens have been described for the morganella morganii antigenic schema. o antigens of the strains representing the new serotypes (o43 :h2 and o44 : h19, 37) are related to yersinia enterocolitica o9 and o17, respectively.	1976	59520
pharmacologic factors which alter the action of narcotic anal.		1976	14583
cyclic guanosine-3',5'-monophosphate--mediator of the action of the hormaone erythropoietin.		1977	18327
subcellular localisation of leucine-enkephalin-hydrolysing activity in rat brain.		1977	19709
the identification of lipid acceptor and the biosynthesis of lipid-linked glucose in bacillus stearothermophilus.		1977	20047
comparison of an aceclidine tremor with arecoline and nicotine ones in rats of different ages.	a comparative characterization of a tremor produced by aceclidine (0.5--200 mg/kg), arecoline (1--30 mg/kg) and nicotine (0.1--8 mg/kg) in rats of different age is given and the influence on the tremor of atropine sulphate (1--100 mg/kg) and scopolamine hydrobromide hydrobromide (2.5 mg/kg) described. the common character of effects produced by aceclidine and arecoline was ascertained. the tremor develops in rats aged 7--8 days and its maximum duration is in rattlings of junior and medium age. m ...	1977	21806
glutamine-requiring mutants of bacillus subtilis.		1977	23122
study on the ion-permeability of human dental enamel with special reference to an electrochemical approach.		1977	34011