Publications
| Title | Abstract | Year(sorted ascending) Filter | PMID Filter |
|---|
| role of the gut microbiota in inflammatory bowel disease pathogenesis: what have we learnt in the past 10 years? | our understanding of the microbial involvement in inflammatory bowel disease (ibd) pathogenesis has increased exponentially over the past decade. the development of newer molecular tools for the global assessment of the gut microbiome and the identification of nucleotide-binding oligomerization domain-containing protein 2 in 2001 and other susceptibility genes for crohn's disease in particular has led to better understanding of the aetiopathogenesis of ibd. the microbial studies have elaborated ... | 2014 | 24574795 |
| anaerobic culture to detect periodontal and caries pathogens. | anaerobic culture has been critical in our understanding of the oral microbiotas. | 2014 | 25678835 |
| anaerobic culture to detect periodontal and caries pathogens. | anaerobic culture has been critical in our understanding of the oral microbiotas. | 2014 | 25678835 |
| molecular identification and antibiotic resistant bacteria isolated from primary dentition infections. | bacterial resistance to antibiotics is a health problem in many parts of the world. the aim of this study was to identify bacteria from dental infections and determine bacterial resistance to antibiotics used in dental care in the primary dentition. | 2014 | 25091293 |
| relationship between halitosis and periodontal disease - associated oral bacteria in tongue coatings. | the objective of our study was to investigate the relationship between halitosis and oral bacteria in tongue coating (tc) and saliva samples from patients with halitosis, and to evaluate the effect of tongue cleaning on halitosis. | 2014 | 23890391 |
| validation of antibiotic efficacy on in vitro subgingival biofilms. | systemic antibiotics are often used as adjunctive treatment modalities for periodontal diseases. testing of antimicrobial efficacy can be relevant only if the bacteria are in the form of biofilms rather than the planktonic state, and at concentrations of physiologic relevance, i.e., reachable in the periodontal pocket. the aim of the present study is to test the antimicrobial efficacy of five common antibiotic schemes at physiologically relevant concentrations on a multispecies in vitro biofilm ... | 2014 | 23659420 |
| cluster of bacteria associated with peri-implantitis. | information on the microbiota in peri-implantitis is limited. we hypothesized that neither gender nor a history of periodontitis/smoking or the microbiota at implants differ by implant status. | 2014 | 23527870 |
| quantification of periodontal pathogens in vascular, blood, and subgingival samples from patients with peripheral arterial disease or abdominal aortic aneurysms. | the aim of this investigation is to quantify periodontal pathogens (aggregatibacter actinomycetemcomitans, porphyromonas gingivalis, campylobacter rectus, and tannerella forsythia) in vascular, blood, and subgingival samples. as a secondary objective, two molecular bacterial identification methods (nested polymerase chain reaction [pcr] and quantitative pcr [qpcr]) are compared. | 2014 | 24502612 |
| the effect of fixed orthodontic appliances and fluoride mouthwash on the oral microbiome of adolescents - a randomized controlled clinical trial. | while the aesthetic effect of orthodontic treatment is clear, the knowledge on how it influences the oral microbiota and the consequential effects on oral health are limited. in this randomized controlled clinical trial we investigated the changes introduced in the oral ecosystem, during and after orthodontic treatment with fixed appliances in combination with or without a fluoride mouthwash, of 10-16.8 year old individuals (n = 91). we followed several clinical parameters in time, in combinatio ... | 2015 | 26332408 |
| toll-like receptors: a key marker for periodontal disease and preterm birth - a contemporary review. | the receptors of the innate immune system have evolved to recognize pathogenic bacteria in a complex manner. out of these immune receptors, the pattern recognition receptors (prrs) such as toll like receptors have gained importance off late to play a key role in the activation of cascade of inflammatory cytokines in pathogenesis of preterm birth. preterm birth has become leading cause of neonatal deaths globally. the concept of oral infection influencing the occurrence of preterm delivery has ga ... | 2015 | 26501032 |
| the oral bacterial communities of children with well-controlled hiv infection and without hiv infection. | the oral microbial community (microbiota) plays a critical role in human health and disease. alterations in the oral microbiota may be associated with disorders such as gingivitis, periodontitis, childhood caries, alveolar osteitis, oral candidiasis and endodontic infections. in the immunosuppressed population, the spectrum of potential oral disease is even broader, encompassing candidiasis, necrotizing gingivitis, parotid gland enlargement, kaposi's sarcoma, oral warts and other diseases. here, ... | 2015 | 26146997 |
| effect of camphylobacter rectus on serum iron and transferrin- in-vivo findings. | periodontopathogens require iron constituents for their growth and metabolism in subgingival crevice. in this study, c.rectus was detected and quantified by using 16s rdna based pcr in chronic periodontitis and compared with the levels of serum iron, total iron binding capacity and transferrin in chronic periodontitis and healthy sites. | 2015 | 26393200 |
| are herpes virus associated to aggressive periodontitis? a review of literature. | periodontal disease includes a wide variety of infectious entities with various clinical manifestations in the oral cavity and responses to treatment. the determinants of clinical manifestations of periodontal disease include the type of infectious agent, the host immune response and environmental factors. aggressive periodontitis (ap) is defined as a type of inflammation with specific clinical and laboratory features, which distinguish it from other types of periodontitis, with high incidence r ... | 2015 | 26980964 |
| novel immunomodulatory flagellin-like protein flac in campylobacter jejuni and other campylobacterales. | the human diarrheal pathogens campylobacter jejuni and campylobacter coli interfere with host innate immune signaling by different means, and their flagellins, flaa and flab, have a low intrinsic property to activate the innate immune receptor toll-like receptor 5 (tlr5). we have investigated here the hypothesis that the unusual secreted, flagellin-like molecule flac present in c. jejuni, c. coli, and other campylobacterales might activate cells via tlr5 and interact with tlr5. flac shows striki ... | 2015 | 27303676 |
| novel immunomodulatory flagellin-like protein flac in campylobacter jejuni and other campylobacterales. | the human diarrheal pathogens campylobacter jejuni and campylobacter coli interfere with host innate immune signaling by different means, and their flagellins, flaa and flab, have a low intrinsic property to activate the innate immune receptor toll-like receptor 5 (tlr5). we have investigated here the hypothesis that the unusual secreted, flagellin-like molecule flac present in c. jejuni, c. coli, and other campylobacterales might activate cells via tlr5 and interact with tlr5. flac shows striki ... | 2015 | 27303676 |
| the expression of gingival epithelial junctions in response to subgingival biofilms. | periodontitis is an infectious inflammatory disease that destroys the tooth-supporting tissues. it is caused by the formation of subgingival biofilms on the surface of the tooth. characteristic bacteria associated with subgingival biofilms are the gram-negative anaerobes porphyromonas gingivalis, tannerella forsythia and treponema denticola, collectively known as the "red complex" species. inter-epithelial junctions ensure the barrier integrity of the gingival epithelium. this may however be dis ... | 2015 | 26305580 |
| microbiological and clinical effects of enamel matrix derivative and sustained-release micro-spherical minocycline application as an adjunct to non-surgical therapy in peri-implant mucosal inflammation. | the purpose of this study was to compare the microbial and clinical effects of mechanical debridement (md) alone or in combination with the application of enamel matrix derivative (emd) and sustained-release micro-spherical minocycline (msm) for treatment of peri-implant mucosal infl ammation (pimi). | 2015 | 26339576 |
| the epigenetic paradigm in periodontitis pathogenesis. | epigenome refers to "epi" meaning outside the "genome." epigenetics is the field of study of the epigenome. epigenetic modifications include changes in the promoter cpg islands, modifications of histone protein structure, posttranslational repression by micro-rna which contributes to the alteration of gene expression. epigenetics provides an understanding of the role of gene-environment interactions on disease phenotype especially in complex multifactorial diseases. periodontitis is a chronic in ... | 2015 | 26015662 |
| exploring salivary microbiota in aids patients with different periodontal statuses using 454 gs-flx titanium pyrosequencing. | patients with acquired immunodeficiency syndrome (aids) are at high risk of opportunistic infections. oral manifestations have been associated with the level of immunosuppression, these include periodontal diseases, and understanding the microbial populations in the oral cavity is crucial for clinical management. the aim of this study was to examine the salivary bacterial diversity in patients newly admitted to the aids ward of the public health clinical center (china). saliva samples were colle ... | 2015 | 26191508 |
| oral campylobacter species: initiators of a subgroup of inflammatory bowel disease? | in recent years, a number of studies detected a significantly higher prevalence of campylobacter species such as campylobacter concisus (c. concisus) in intestinal biopsies and fecal samples collected from patients with inflammatory bowel disease (ibd) compared to controls. most of these campylobacter species are not of zoonotic origin but are human oral campylobacter species. bacterial species usually cause diseases in the location where they colonize. however, c. concisus and other oral campyl ... | 2015 | 26309350 |
| functional signatures of oral dysbiosis during periodontitis progression revealed by microbial metatranscriptome analysis. | periodontitis is a polymicrobial biofilm-induced inflammatory disease that affects 743 million people worldwide. the current model to explain periodontitis progression proposes that changes in the relative abundance of members of the oral microbiome lead to dysbiosis in the host-microbiome crosstalk and then to inflammation and bone loss. using combined metagenome/metatranscriptome analysis of the subgingival microbiome in progressing and non-progressing sites, we have characterized the distinct ... | 2015 | 25918553 |
| a randomized clinical trial of an adjunct diode laser application for the nonsurgical treatment of peri-implantitis. | in this radiographic and microbiologic split-mouth clinical trial, efficacy of a diode laser as an adjunct to conventional scaling in the nonsurgical treatment of peri-implantitis was investigated. | 2015 | 26382562 |
| pseudomonas aeruginosa and periodontal pathogens in the oral cavity and lungs of cystic fibrosis patients: a case-control study. | cystic fibrosis (cf) is the most frequent lethal genetic disease in the caucasian population. lung destruction is the principal cause of death by chronic pseudomonas aeruginosa colonization. there is a high prevalence of oropharyngeal anaerobic bacteria in sputum of cf patients. this study was carried out due to the lack of results comparing subgingival periodontal pathogenic bacteria between the oral cavity and lungs in patients with cf in relation with p. aeruginosa presence. our first goal wa ... | 2015 | 25854483 |
| quantitative proteomics reveal distinct protein regulations caused by aggregatibacter actinomycetemcomitans within subgingival biofilms. | periodontitis is an infectious disease that causes the inflammatory destruction of the tooth-supporting (periodontal) tissues, caused by polymicrobial biofilm communities growing on the tooth surface. aggressive periodontitis is strongly associated with the presence of aggregatibacter actinomycetemcomitans in the subgingival biofilms. nevertheless, whether and how a. actinomycetemcomitans orchestrates molecular changes within the biofilm is unclear. the aim of this work was to decipher the inter ... | 2015 | 25756960 |
| relationship between invasion of the periodontium by periodontal pathogens and periodontal disease: a systematic review. | bacterial invasion of the periodontal tissues has been suggested as a relevant step in the etiopathogenesis of periodontal disease. however, its exact importance remains to be defined. the present systematic review assessed the scientific evidence concerning the relationship between the quality or quantity of periodontal microbiota in periodontal tissues and development of periodontal disease. the databases medline-pubmed, cochrane-central, isi web of knowledge and scopus were searched, up to ja ... | 2015 | 25654367 |
| establishment of an oral infection model resembling the periodontal pocket in a perfusion bioreactor system. | periodontal infection involves a complex interplay between oral biofilms, gingival tissues and cells of the immune system in a dynamic microenvironment. a humanized in vitro model that reduces the need for experimental animal models, while recapitulating key biological events in a periodontal pocket, would constitute a technical advancement in the study of periodontal disease. the aim of this study was to use a dynamic perfusion bioreactor in order to develop a gingival epithelial-fibroblast-mon ... | 2015 | 25587671 |
| tlr expression profile of human gingival margin-derived stem progenitor cells. | gingival margin-derived stem/progenitor cells (g-mscs) show remarkable periodontal regenerative potential in vivo. during regeneration, g-mscs may interact with their inflammatory environment via toll-like-receptors (tlrs). the present study aimed to depict the g-mscs tlrs expression profile. | 2015 | 26615501 |
| periodontal microbiota and phospholipases: the oral infections and vascular disease epidemiology study (invest). | periodontal infections have been linked to cardiovascular disease, including atherosclerosis, and systemic inflammation has been proposed as a possible mediator. secretory phospholipase a2 (s-pla2) and lipoprotein-associated pla2 (lp-pla2) are inflammatory enzymes associated with atherosclerosis. no data are available on the association between oral microbiota and pla2s. we studied whether a relationship exists between periodontal microbiota and the activities of these enzymes. | 2015 | 26282947 |
| a biofilm pocket model to evaluate different non-surgical periodontal treatment modalities in terms of biofilm removal and reformation, surface alterations and attachment of periodontal ligament fibroblasts. | there is a lack of suitable in vitro models to evaluate various treatment modalities intending to remove subgingival bacterial biofilm. consequently, the aims of this in vitro-study were: a) to establish a pocket model enabling mechanical removal of biofilm and b) to evaluate repeated non-surgical periodontal treatment with respect to biofilm removal and reformation, surface alterations, tooth hard-substance-loss, and attachment of periodontal ligament (pdl) fibroblasts. | 2015 | 26121365 |
| increased infection with key periodontal pathogens during gestational diabetes mellitus. | gestational diabetes mellitus (gdm), gingivitis, infection with specific periodontal pathogens and systemic inflammation each increase the risk for poor pregnancy outcome. we set out to monitor the interactions of gingivitis and gdm with respect to oral infection and the systemic inflammatory burden. | 2015 | 25959628 |
| a randomized trial of ethyl lauroyl arginate-containing mouthrinse in the control of gingivitis. | this 4-week, single-centre, randomized, examiner-blind, controlled study investigated the efficacy and safety of 0.15% ethyl lauroyl arginate (lae)-containing mouthrinse in adults with mild-to-moderate gingivitis. | 2015 | 26087864 |
| effects of azithromycin, metronidazole, amoxicillin, and metronidazole plus amoxicillin on an in vitro polymicrobial subgingival biofilm model. | chronic periodontitis is one of the most prevalent human diseases and is caused by dysbiosis of the subgingival microbiota. treatment involves primarily mechanical disruption of subgingival biofilms and, in certain cases, adjunctive use of systemic antibiotic therapy. in vitro biofilm models have been developed to study antimicrobial agents targeting subgingival species. however, these models accommodate a limited number of taxa, lack reproducibility, and have low throughput. we aimed to develop ... | 2015 | 25733510 |
| comparison of oral microbial profiles between children with severe early childhood caries and caries-free children using the human oral microbe identification microarray. | early childhood caries (ecc) has become a prevalent public health problem among chinese preschool children. the bacterial microflora is considered to be an important factor in the formation and progress of dental caries. however, high-throughput and large-scale studies of the primary dentition are lacking. the present study aimed to compare oral microbial profiles between children with severe ecc (secc) and caries-free children. | 2015 | 25821962 |
| global epidemiology of campylobacter infection. | campylobacter jejuni infection is one of the most widespread infectious diseases of the last century. the incidence and prevalence of campylobacteriosis have increased in both developed and developing countries over the last 10 years. the dramatic increase in north america, europe, and australia is alarming, and data from parts of africa, asia, and the middle east indicate that campylobacteriosis is endemic in these areas, especially in children. in addition to c. jejuni, there is increasing rec ... | 2015 | 26062576 |
| effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - a clinicobiochemical study. | the impact of simvastatin (smv), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. the present study aims to evaluate the in vivo effect of subgingivally delivered smv gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (il-6), interleukin-8 (il-8) and interleukin-10 (il-10 ... | 2015 | 27195204 |
| effect of topical simvastatin (1.2 mg) on gingival crevicular fluid interleukin-6, interleukin-8 and interleukin-10 levels in chronic periodontitis - a clinicobiochemical study. | the impact of simvastatin (smv), a cholesterol lowering drug, on bone metabolism appears to involve complex interaction with cholesterol metabolites, hormones, inflammatory mediators and growth factors, thus having direct influence on extent and severity of periodontitis. the present study aims to evaluate the in vivo effect of subgingivally delivered smv gel (1.2 mg) as a local drug-delivery agent on clinical parameters and on interleukin-6 (il-6), interleukin-8 (il-8) and interleukin-10 (il-10 ... | 2015 | 27195204 |
| photodynamic therapy in the treatment of aggressive periodontitis: a systematic review. | aggressive periodontitis (agp) is a severe form of periodontal diseases with rapid destruction of the supporting bone around teeth. the efficacy of pdt in suppressing periodontal pathogens may be crucial in adopting new protocols for the treatment of agp. thus, the aim of this systematic review was to investigate the possible role of pdt in the treatment of agp as an adjunctive therapy or monotherapy. | 2015 | 26595837 |
| quantitation of biofilm and planktonic life forms of coexisting periodontal species. | complexity of oral polymicrobial communities has prompted a need for developing in vitro models to study behavior of coexisting bacteria. little knowledge is available of in vitro co-growth of several periodontitis-associated species without early colonizers of dental plaque. | 2015 | 25926392 |
| occurrence of periodontal pathogens in ethnic groups from a native brazilian reservation. | the present study was designed to evaluate the occurrence of periodontal pathogens in the subgingival biofilm of 100 native brazilians living at the umutina indian reservation, mato grosso state, brazil. | 2015 | 25847068 |
| microbial leakage at the implant-abutment connection due to implant insertion maneuvers: cross-sectional study 5 years postloading in healthy patients. | the aim of this study was to test if stress on the prosthetic connection during insertion maneuvers can induce micro-warping at the implant connection. from september 2011 to july 2013, patients with implants loaded for at least 5 years that were placed with 2 different insertion implant mounters-mp (conventional) and me (mountless)-were selected from all of those who had received dental implant therapy in the past and were attending routine check-up or spontaneous visits during the study period ... | 2015 | 25536224 |
| distribution of 8 periodontal microorganisms in family members of chinese patients with aggressive periodontitis. | to date, no information on the distribution of periodontal microorganisms among family members of chinese patients with aggressive peridontitis (agp) is available. the aim of the present study was to investigate the probability of transmission of eight periodontal microorganisms between patients with aggressive periodontitis and their family members. | 2015 | 25526624 |
| regulation of adrenomedullin and nitric oxide production by periodontal bacteria. | in periodontitis the host response to bacterial challenge includes activity of the multifunctional molecules adrenomedullin (am) and nitric oxide (no). the aim of this study was to investigate the role of periodontal bacteria in regulating the production of these molecules from cultured cells. | 2015 | 25440112 |
| microbiological assessment of the implant-abutment interface in different connections: cross-sectional study after 5 years of functional loading. | to evaluate the bacterial microflora present inside the implant connection and in the peri-implant sulcus fluid of healthy implants, and to analyze the relationships between these harboring sites for four different implant systems after at least 5 years of functional loading. | 2015 | 24665919 |
| photodynamic therapy in the treatment of aggressive periodontitis: a systematic review. | aggressive periodontitis (agp) is a severe form of periodontal diseases with rapid destruction of the supporting bone around teeth. the efficacy of pdt in suppressing periodontal pathogens may be crucial in adopting new protocols for the treatment of agp. thus, the aim of this systematic review was to investigate the possible role of pdt in the treatment of agp as an adjunctive therapy or monotherapy. | 2015 | 26595837 |
| in vitro culture of previously uncultured oral bacterial phylotypes. | around a third of oral bacteria cannot be grown using conventional bacteriological culture media. community profiling targeting 16s rrna and shotgun metagenomics methods have proved valuable in revealing the complexity of the oral bacterial community. studies investigating the role of oral bacteria in health and disease require phenotypic characterizations that are possible only with live cultures. the aim of this study was to develop novel culture media and use an in vitro biofilm model to cult ... | 2015 | 26407883 |
| systemic effects of periodontitis: lessons learned from research on atherosclerotic vascular disease and adverse pregnancy outcomes. | studies conducted over the past 25 years have focussed on the role of periodontitis, an inflammatory condition of microbial aetiology that destroys the tooth-supporting tissues, as a systemic inflammatory stressor that can act as an independent risk factor of atherosclerotic vascular disease (avsd) and adverse pregnancy outcomes (apos). it has been suggested that periodontitis-associated bacteraemias and systemic dissemination of inflammatory mediators produced in the periodontal tissues may res ... | 2015 | 26388299 |
| synergic phototoxic effect of visible light or gallium-arsenide laser in the presence of different photo-sensitizers on porphyromonas gingivalis and fusobacterium nucleatum. | according to the development of resistant strains of pathogenic bacteria following treatment with antimicrobial chemotherapeutic agents, alternative approaches such as lethal photosensitization are being used. the aim of this study was to evaluate the effect of visible light and laser beam radiation in conjugation with three different photosensitizers on the survival of two main periodontopathogenic bacteria including porphyromonas gingivalis and fusobacterium nucleatum in different exposure per ... | 2015 | 26288621 |
| nodulation characterization and proteomic profiling of bradyrhizobium liaoningense ccbau05525 in response to water-soluble humic materials. | the lignite biodegradation procedure to produce water-soluble humic materials (wshm) with a penicillium stain was established by previous studies in our laboratory. this study researched the effects of wshm on the growth of bradyrhizobium liaoningense ccbau05525 and its nodulation on soybean. results showed that wshm enhanced the cell density of ccbau05525 in culture, and increased the nodule number, nodule fresh weight and nitrogenase activity of the inoculated soybean plants. then the chemical ... | 2015 | 26054030 |
| the influence and role of microbial factors in autoimmune kidney diseases: a systematic review. | a better understanding of the pathophysiology of autoimmune disorders is desired to allow tailored interventions. despite increased scientific interest a direct pathogenic factor in autoimmune renal disease has been described only in a minority like membranous nephropathy or anca-associated vasculitis. nonetheless the initial step leading to the formation of these antibodies is still obscure. in this review we will focus on the possible role of microbial factors in this context. staphylococcus a ... | 2015 | 26078982 |
| abnormal pregnancy outcomes in mice using an induced periodontitis model and the haematogenous migration of fusobacterium nucleatum sub-species to the murine placenta. | to investigate if there is subspecies specific migration to the placenta by fusobacterium nucleatum (fn) and to determine whether experimentally induced periodontitis results in adverse pregnancy outcomes (apo) in mice. | 2015 | 25806806 |
| inhibition of sphingosine kinase prevents lipopolysaccharide-induced preterm birth and suppresses proinflammatory responses in a murine model. | premature delivery occurs in 12% of all births, and accounts for nearly half of long-term neurological morbidity, and 60% to 80% of perinatal mortality. despite advances in obstetrics and neonatology, the rate of premature delivery has increased approximately 12% since 1990. the single most common cause of spontaneous preterm birth is infection. several lines of evidence have demonstrated the role of endothelin-1 as both a constrictor of uterine myometrial smooth muscle and a proinflammatory med ... | 2015 | 25579843 |
| periodontal health awareness among gynecologists in riyadh, saudi arabia. | to determine the knowledge of periodontal disease and pregnancy outcomes among the gynecologists practicing in riyadh, saudi arabia. | 2015 | 26236681 |
| oxidative stress and igg antibody modify periodontitis-crp association. | in a previous report, we demonstrated the inverse association of high serum 8-isoprostane levels, a marker for oxidative stress, with decreased serum igg antibodies to oral bacteria. the association between increased serum igg with increased plaque and periodontitis (increased probing depths) was attenuated by high systemic oxidative stress. other investigations have reported a role for systemic oxidative stress as a stimulus of hepatic c-reactive protein (crp) response. these observations led u ... | 2015 | 26318589 |
| tlr expression profile of human gingival margin-derived stem progenitor cells. | gingival margin-derived stem/progenitor cells (g-mscs) show remarkable periodontal regenerative potential in vivo. during regeneration, g-mscs may interact with their inflammatory environment via toll-like-receptors (tlrs). the present study aimed to depict the g-mscs tlrs expression profile. | 2015 | 26615501 |
| the biofilm community-rebels with a cause. | oral biofilms are one of the most complex and diverse ecosystem developed by successive colonization of more than 600 bacterial taxa. development starts with the attachment of early colonizers such as actinomyces species and oral streptococci on the acquired pellicle and tooth enamel. these bacteria not only adhere to tooth surface but also interact with each other and lay foundation for attachment of bridging colonizer such as fusobacterium nucleatum followed by late colonizers including the re ... | 2015 | 26120510 |
| smrt sequencing of the campylobacter coli bfr-ca-9557 genome sequence reveals unique methylation motifs. | campylobacter species are the most prevalent bacterial pathogen causing acute enteritis worldwide. in contrast to campylobacter jejuni, about 5 % of campylobacter coli strains exhibit susceptibility to restriction endonuclease digestion by dpni cutting specifically 5'-g(m)atc-3' motifs. this indicates significant differences in dna methylation between both microbial species. the goal of the study was to analyze the methylome of a c. coli strain susceptible to dpni digestion, to identify its meth ... | 2015 | 26689587 |
| the inflammasome and danger molecule signaling: at the crossroads of inflammation and pathogen persistence in the oral cavity. | inflammasomes are an oligomeric assembly of multiprotein complexes that activate the caspase-1-dependent maturation and the subsequent secretion of inflammatory interleukin-1beta and interleukin-18 cytokines in response to a 'danger signal' in vertebrates. the assessment of their significance continues to grow rapidly as the complex biology of various chronic inflammatory conditions is better dissected. increasing evidence strongly links inflammasomes and host-derived small 'danger molecule atp' ... | 2015 | 26252403 |
| point-of-care diagnosis of periodontitis using saliva: technically feasible but still a challenge. | periodontitis is a chronic inflammation of the periodontium caused by persistent bacterial infection that leads to the breakdown of connective tissue and bone. because the ability to reconstruct the periodontium is limited after alveolar bone loss, early diagnosis and intervention should be the primary goals of periodontal treatment. however, periodontitis often progresses without noticeable symptoms, and many patients do not seek professional dental care until the periodontal destruction progre ... | 2015 | 26389079 |
| pancreatic amylase is an environmental signal for regulation of biofilm formation and host interaction in campylobacter jejuni. | campylobacter jejuni is a commensal bacterium in the intestines of animals and birds and a major cause of food-borne gastroenteritis in humans worldwide. here we show that exposure to pancreatic amylase leads to secretion of an α-dextran by c. jejuni and that a secreted protease, cj0511, is required. exposure of c. jejuni to pancreatic amylase promotes biofilm formation in vitro, increases interaction with human epithelial cell lines, increases virulence in the galleria mellonella infection mode ... | 2015 | 26438798 |
| relationship between gingival inflammation and pregnancy. | an increase in the prevalence and severity of gingival inflammation during pregnancy has been reported since the 1960s. though the etiology is not fully known, it is believed that increasing plasma sex steroid hormone levels during pregnancy have a dramatic effect on the periodontium. current works of research have shown that estrogen and progesterone increasing during pregnancy are supposed to be responsible for gingivitis progression. this review is focused not only on epidemiological studies, ... | 2015 | 25873767 |
| should antibiotics be prescribed to treat chronic periodontitis? | although scaling and root planing is a cost-effective approach for initial treatment of chronic periodontitis, it fails to eliminate subgingival pathogens and halt progressive attachment loss in some patients. adjunctive use of systemic antibiotics immediately after completion of scaling and root planing can enhance the degree of clinical attachment gain and probing depth reduction provided by nonsurgical periodontal treatment. this article discusses the rationale for prescribing adjunctive anti ... | 2015 | 26427574 |
| bacterial profile of aggressive periodontitis in morocco: a cross-sectional study. | aggressive periodontitis (agp) is one of the most severe forms of periodontal diseases. in morocco, aggregatibacter actinomycetemcomitans has been strongly associated with agp, however limited knowledge is available about the implication of other periodontal pathogens in this entity. therefore, the main aim of this study was to evaluate the composition of the subgingival microbiota in moroccan patients with agp. | 2015 | 25888404 |
| periodontal diseases: bug induced, host promoted. | 2015 | 26226364 | |
| towards microbiome transplant as a therapy for periodontitis: an exploratory study of periodontitis microbial signature contrasted by oral health, caries and edentulism. | conventional periodontal therapy aims at controlling supra- and subgingival biofilms. although periodontal therapy was shown to improve periodontal health, it does not completely arrest the disease. almost all subjects compliant with periodontal maintenance continue to experience progressive clinical attachment loss and a fraction of them loses teeth. an oral microbial transplant may be a new alternative for treating periodontitis (inspired by fecal transplant). first, it must be established tha ... | 2015 | 26468081 |
| incorporation of staphylococci into titanium-grown biofilms: an in vitro "submucosal" biofilm model for peri-implantitis. | staphylococcus spp. are postulated to play a role in peri-implantitis. this study aimed to develop a "submucosal" in vitro biofilm model, by integrating two staphylococci into its composition. | 2015 | 26461083 |
| incorporation of staphylococci into titanium-grown biofilms: an in vitro "submucosal" biofilm model for peri-implantitis. | staphylococcus spp. are postulated to play a role in peri-implantitis. this study aimed to develop a "submucosal" in vitro biofilm model, by integrating two staphylococci into its composition. | 2015 | 26461083 |
| the influence of smoking on the peri-implant microbiome. | smokers are at high risk for 2 bacterially driven oral diseases: peri-implant mucositis and peri-implantitis. therefore, the purpose of this investigation was to use a deep-sequencing approach to identify the effect of smoking on the peri-implant microbiome in states of health and disease. peri-implant biofilm samples were collected from 80 partially edentulous subjects with peri-implant health, peri-implant mucositis, and peri-implantitis. bacterial dna was isolated and 16s ribsomal rna gene li ... | 2015 | 26124222 |
| periodontal bacteria and prediabetes prevalence in origins: the oral infections, glucose intolerance, and insulin resistance study. | periodontitis and type 2 diabetes mellitus are known to be associated. the relationship between periodontal microbiota and early diabetes risk has not been studied. we investigated the association between periodontal bacteria and prediabetes prevalence among diabetes-free adults. origins (the oral infections, glucose intolerance and insulin resistance study) cross sectionally enrolled 300 diabetes-free adults aged 20 to 55 y (mean ± sd, 34 ± 10 y; 77% female). prediabetes was defined as follows: ... | 2015 | 26082387 |
| effects of hangeshashinto on growth of oral microorganisms. | oral mucositis (om) in cancer patients induced by chemotherapy or radiotherapy has a significant impact on quality of life, and causes considerable morbidity. oral microorganisms are likely to intensify the inflammatory process and aggravate the formation of ulcers. hangeshashinto (hst), a japanese kampo medicine, has been reported to be effective when used as a gargle for the treatment of om. to clarify the effects of hst on oral microorganisms, we assessed its antimicrobial activity against 27 ... | 2015 | 26170876 |
| long-term evaluation of the antimicrobial susceptibility and microbial profile of subgingival biofilms in individuals with aggressive periodontitis. | this study evaluates the antimicrobial susceptibility and composition of subgingival biofilms in generalized aggressive periodontitis (gap) patients treated using mechanical/antimicrobial therapies, including chlorhexidine (chx), amoxicillin (amx) and metronidazole (met). gap patients allocated to the placebo (c, n = 15) or test group (t, n = 16) received full-mouth disinfection with chx, scaling and root planning, and systemic amx (500 mg)/met (250 mg) or placebos. subgingival plaque samples we ... | 2015 | 26273264 |
| proteomic profiling of host-biofilm interactions in an oral infection model resembling the periodontal pocket. | periodontal infections cause inflammatory destruction of the tooth supporting tissues. we recently developed a dynamic, in vitro periodontal organotypic tissue model in a perfusion bioreactor system, in co-culture with an 11-species subgingival biofilm, which may recapitulate early events during the establishment of periodontal infections. this study aimed to characterize the global proteome regulations in this host-biofilm interaction model. semi-quantitative shotgun proteomics were applied for ... | 2015 | 26525412 |
| associations between periodontal microbiota and death rates. | it is conceived that specific combinations of periodontal bacteria are associated with risk for the various forms of periodontitis. we hypothesized that such specificity is also related to human cause-specific death rates. we tested this hypothesis in a representative sample of the us population followed for a mean duration of 11 years and found that two specific patterns of 21 serum antibodies against periodontal bacteria were significantly associated with increased all-cause and/or diabetes-re ... | 2016 | 27748442 |
| salivary periodontopathic bacteria in children and adolescents with down syndrome. | to assess and compare salivary periodontopathic bacteria between groups of down syndrome and non-down syndrome children and adolescents. | 2016 | 27727287 |
| sensitivity and specificity of subgingival bacteria in predicting preterm birth- a pilot cohort study. | preterm birth (ptb) increases the risk of adverse outcomes for new born infants. subgingival bacteria are implicated in causing ptb. the aim of the present study was to assess the accuracy of some subgingival gram positive and gram negative bacteria detected by routine lab procedures in predicting ptb. | 2016 | 27833518 |
| microbial profiles and detection techniques in peri-implant diseases: a systematic review. | to describe the microbial profiles of peri-implant diseases and the main detection methods. | 2016 | 27833735 |
| the role of nutrition in periodontal health: an update. | periodontal health is influenced by a number of factors such as oral hygiene, genetic and epigenetic factors, systemic health, and nutrition. many studies have observed that a balanced diet has an essential role in maintaining periodontal health. additionally, the influences of nutritional supplements and dietary components have been known to affect healing after periodontal surgery. studies have attempted to find a correlation between tooth loss, periodontal health, and nutrition. moreover, bon ... | 2016 | 27589794 |
| oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis and after kidney transplantation. | aim of this single center cross-sectional study was to investigate oral behavior, dental, periodontal and microbiological findings in patients undergoing hemodialysis (hd) and after kidney transplantation (kt). | 2016 | 27531498 |
| clinical, radiographic and microbiological evaluation of high level laser therapy, a new photodynamic therapy protocol, in peri-implantitis treatment; a pilot experience. | aim. endosseous implants are widely used to replace missing teeth but mucositis and peri-implantitis are the most frequent long-term complications related with dental implants. removing all bacterial deposits on contaminated implant surface is very difficult due to implant surface morphology. the aim of this study was to evaluate the bactericidal potential of photodynamic therapy by using a new high level laser irradiation protocol associated with hydrogen peroxide in peri-implantitis. materials ... | 2016 | 27379251 |
| adjunctive use of essential oils following scaling and root planing -a randomized clinical trial. | hitherto no study has been published on the effect of the adjunctive administration of essential oils following scaling and root planing (srp). this study describes the effect of a mouthrinse consisting of essential oils (cymbopogon flexuosus, thymus zygis and rosmarinus officinalis) following srp by clinical and microbiological variables in patients with generalized moderate chronic periodontitis. | 2016 | 27266517 |
| quantitative molecular detection of 19 major pathogens in the interdental biofilm of periodontally healthy young adults. | in oral health, the interdental spaces are a real ecological niche for which the body has few or no alternative defenses and where the traditional daily methods for control by disrupting biofilm are not adequate. the interdental spaces are the source of many hypotheses regarding their potential associations with and/or causes of cardiovascular disease, diabetes, chronic kidney disease, degenerative disease, and depression. this pcr study is the first to describe the interdental microbiota in hea ... | 2016 | 27313576 |
| frequency of periodontal pathogens and helicobacter pylori in the mouths and stomachs of obese individuals submitted to bariatric surgery: a cross-sectional study. | this cross-sectional study compared the frequency of oral periodontopathogens and h. pylori in the mouths and stomachs of obese individuals with or without periodontitis submitted to bariatric surgery. | 2016 | 27383704 |
| nonsyndromic localized aggressive periodontitis of primary dentition: a rare case report. | periodontitis is an inflammatory disease of the gingiva and tissues of the periodontium. it is characterized by pocket formation and destruction of supporting alveolar bone. periodontal diseases of aggressive nature are not very common in children. they are usually associated with systemic conditions. the present case report is of a 5-year-old male child who reported with rapid attachment loss and bony defects of the gingiva and supporting structures. his family and medical history gave no contr ... | 2016 | 27307682 |
| accuracy of commercial kits and published primer pairs for the detection of periodontopathogens. | despite the input of microbiome research, a group of 20 bacteria continues to be the focus of periodontal diagnostics and therapy. the aim of this study was to compare three commercial kits and laboratory-developed primer pairs for effectiveness in detecting such periodontopathogens. | 2016 | 27020914 |
| detection of cfxa2, cfxa3, and cfxa6 genes in beta-lactamase producing oral anaerobes. | purpose the aim of this study was to identify β-lactamase-producing oral anaerobic bacteria and screen them for the presence of cfxa and blatem genes that are responsible for β-lactamase production and resistance to β-lactam antibiotics. material and methods periodontal pocket debris samples were collected from 48 patients with chronic periodontitis and anaerobically cultured on blood agar plates with and without β-lactam antibiotics. presumptive β-lactamase-producing isolates were evaluated for ... | 2016 | 27119762 |
| periodontal disease's contribution to alzheimer's disease progression in down syndrome. | people with down syndrome (ds) are at an increased risk for alzheimer's disease (ad). after 60 years of age, >50% of ds subjects acquire dementia. nevertheless, the age of onset is highly variable possibly because of both genetic and environmental factors. genetics cannot be modified, but environmental risk factors present a potentially relevant intervention for ds persons at risk for ad. among them, inflammation, important in ad of ds type, is potential target. consistent with this hypothesis, ... | 2016 | 27239536 |
| influence of type 2 diabetes on prevalence of key periodontal pathogens, salivary matrix metalloproteinases, and bone remodeling markers in sudanese adults with and without chronic periodontitis. | this study compared the influence of type 2 diabetes on the occurrence of six periodontal pathogens in plaque samples of patients with and without chronic periodontitis. levels of salivary mmp-8, mmp-9, rankl, and opg were also investigated. the study enrolled 31 patients with type 2 diabetes and chronic periodontitis (dm + cp), 29 with chronic periodontitis (cp), and 20 with type 2 diabetes (dm). questionnaire-guided interviews were conducted and plaque index, bleeding on probing, and pocket de ... | 2016 | 26989414 |
| mefit: merging and filtering tool for illumina paired-end reads for 16s rrna amplicon sequencing. | recent advances in next-generation sequencing have revolutionized genomic research. 16s rrna amplicon sequencing using paired-end sequencing on the miseq platform from illumina, inc., is being used to characterize the composition and dynamics of extremely complex/diverse microbial communities. for this analysis on the illumina platform, merging and quality filtering of paired-end reads are essential first steps in data analysis to ensure the accuracy and reliability of downstream analysis. | 2016 | 27905885 |
| influence of highly-active antiretroviral therapy on the subgingival biofilm in hiv-infected patients. | highly-active antiretroviral therapy (haart) has been associated with alterations in subgingival biofilm and periodontal disease. the purpose of the present study was to investigate the association between different haart regimens and the prevalence of periodontal pathogens in hiv-infected patients with chronic periodontitis. | 2016 | 25283543 |
| microbial dynamics during conversion from supragingival to subgingival biofilms in an in vitro model. | the development of dental caries and periodontal diseases result from distinct shifts in the microbiota of the tooth-associated biofilm. this in vitro study aimed to investigate changes in biofilm composition and structure, during the shift from a 'supragingival' aerobic profile to a 'subgingival' anaerobic profile. biofilms consisting of actinomyces oris, candida albicans, fusobacterium nucleatum, streptococcus oralis, streptococcus mutans and veillonella dispar were aerobically grown in saliva ... | 2016 | 26033167 |
| comparison of the detection of periodontal pathogens in bacteraemia after tooth brushing by culture and molecular techniques. | the prevalence and amounts of periodontal pathogens detected in bacteraemia samples after tooth brushing-induced by means of four diagnostic technique, three based on culture and one in a molecular-based technique, have been compared in this study. | 2016 | 26946197 |
| polymerase chain reaction: a molecular diagnostic tool in periodontology. | this review discusses the principles of polymerase chain reaction (pcr) and its application as a diagnostic tool in periodontology. the relevant medline and pubmed indexed journals were searched manually and electronically by typing pcr, applications of pcr, pcr in periodontics, polymorphism studies in periodontitis, and molecular techniques in periodontology. the searches were limited to articles in english language and the articles describing pcr process and its relation to periodontology were ... | 2016 | 27143822 |
| porphyromonas gingivalis within placental villous mesenchyme and umbilical cord stroma is associated with adverse pregnancy outcome. | intrauterine presence of porphyromonas gingivalis (pg), a common oral pathobiont, is implicated in preterm birth. our aim was to determine if the location of pg within placental and/or umbilical cord sections was associated with a specific delivery diagnosis at preterm delivery (histologic chorioamnionitis, chorioamnionitis with funisitis, preeclampsia, and preeclampsia with hellp-syndrome, small for gestational age). the prevalence and location of pg within archived placental and umbilical cord ... | 2016 | 26731111 |
| the current weight of evidence of the microbiologic profile associated with peri-implantitis: a systematic review. | there is currently no consensus regarding microorganisms that may be considered true peri-implant pathogens. therefore, the aim of this systematic review is to determine the weight of evidence for microorganisms related to peri-implantitis based on results of association studies. | 2016 | 27420109 |
| first report of severe acute otitis media caused by campylobacter rectus and review of the literature. | campylobacter rectus is a member of the human oral flora and is associated with periodontal disease. we report the first case of severe acute otitis media (aom) due to c. rectus in a previous healthy 15-year-old boy, which was confirmed by 16s ribosomal rna gene sequencing. c. rectus is a possible causative pathogen of aom. | 2016 | 27363873 |
| microbial complexes levels in conventional and self-ligating brackets. | the aims were to evaluate the levels of bacterial species in saliva and in situ and to assess whether the design of brackets influences the risk of developing periodontal disease. | 2016 | 27270902 |
| periodontal pathogens and risk of incident cancer in postmenopausal females: the buffalo osteoperio study. | extraoral translocation of oral bacteria may contribute to associations between periodontal disease and cancer. the associations among the presence of three orange-complex periodontal pathogens (fusobacterium nucleatum, prevotella intermedia, and campylobacter rectus), two red-complex periodontal pathogens (porphyromonas gingivalis and tannerella forsythia), and cancer risk were investigated. | 2016 | 26513268 |
| does obesity influence the subgingival microbiota composition in periodontal health and disease? | to evaluate whether obesity affects the subgingival microbial composition of patients with periodontal health or chronic periodontitis (cp). | 2016 | 27717180 |
| longitudinal study on clinical and microbial analysis of periodontal status in pregnancy. | this study was aimed to provide a longitudinal overview of the subgingival bacterial microbiome using fluorescence in situ hybridization (fish) technique, in women in the second trimester of pregnancy (between 14 and 24 weeks), and 48 h and 8 weeks postpartum. of 31 women evaluated during pregnancy, 24 returned for the 48-h and 18 for their 8-week exams postpartum. probing depth (pd), bleeding on probing, clinical attachment level, and presence of calculus were recorded. subgingival plaque sampl ... | 2016 | 27556678 |
| bacterial load of periodontal pathogens among italian patients with chronic periodontitis: a comparative study of three different areas. | the aim of the present study was to evaluate the mean bacterial load of some periodontal pathogenic bacteria in italian patients affected by chronic periodontitis. the sample consisted of 1,762 patients with a clinical diagnosis of chronic periodontitis based on the criteria of the american academy of periodontology sampled in the period 2013-2015; 1,323 patients were from northern italy, 317 from central italy and 122 from southern italy. samples for microbiological analysis were collected from ... | 2016 | 27469562 |
| evaluation of the efficacy of a new oral gel containing carvacrol and thymol for home oral care in the management of chronic periodontitis using pcr analysis: a microbiological pilot study. | the use of chemical devices for domestic oral hygiene in periodontal patients has led to new treatment strategies aiming primarily at a control of infection. over the last few years, carvacrol and thymol (ct) have been subjected to many scientific and medical studies. the purpose of the present study was to assess the effect of ct on the red complex bacteria using polymerase chain reaction (pcr) for microbiological analysis. five patients with a diagnosis of chronic periodontitis in the age grou ... | 2016 | 27469559 |