Publications

fungal opportunistic pneumonias in hiv/aids patients: an indian tertiary care experience.	opportunistic pneumonias are a major cause of mortality and morbidity in human immunodeficiency virus (hiv) reactive patients. despite the significant role that fungi play in causation of this opportunistic mycoses, very few indian studies have attempted to investigate the burden and aetiological spectrum of hiv/aids-associated fungal pneumonias.	2017	28384860
pulmonary aspergillosis as opportunistic mycoses in a cohort of human immunodeficiency virus-infected patients: report from a tertiary care hospital in north india.	the incidence of pulmonary aspergillosis in human immunodeficiency virus (hiv)-infected persons is rising. this study was designed to determine the prevalence of pulmonary aspergillosis in a cohort of hiv-positive patients (n = 71) presenting with lower respiratory tract infection at a tertiary care medical center in india.	2017	28539863
treatment of pneumocystis jirovecii pneumonia in hiv-infected patients: a review.	pneumocystis pneumonia is a potentially life-threatening pulmonary infection that occurs in immunocompromised individuals and hiv-infected patients with a low cd4 cell count. trimethoprim-sulfamethoxazole has been used as the first-line agent for treatment, but mutations within dihydropteroate synthase gene render potential resistance to sulfamide. despite advances of combination antiretroviral therapy (cart), pneumocystis pneumonia continues to occur in hiv-infected patients with late presentat ...	2017	28782390
in-patient mortality among plhiv: a 7-year hospital-based retrospective study in coastal south india.	with the wide usage of highly active antiretroviral therapy, the morbidity and mortality due to hiv have declined gradually. the aim of our study was to determine the cause of mortality among hiv-infected patients and the factors causing early death.	2017	28555517
pneumocystis carinii infection with severe pneumomediastinum and lymph node involvement in a whippet mixed-breed dog.	a 3.5-y-old whippet mixed-breed dog was presented with a history of respiratory distress, exercise intolerance, and generalized demodicosis. hematologic alterations included marked leukocytosis and neutrophilia. radiographic examination showed a diffuse interstitial and mild peripheral alveolar lung pattern and pneumomediastinum. because the cytologic examination of the bronchoalveolar aspirate was not diagnostic and a persistent perforation of the upper respiratory tract could not be ruled out, ...	2017	28548623
nodular regenerative hyperplasia: a case of rare prognosis.	introduction: nodular regenerative hyperplasia (nrh) is a known etiology of noncirrhotic portal hypertension. cases of biopsy-proven nrh in human immunodeficiency virus (hiv)-positive patients have been described. while these patients often have normal synthetic liver function, several reports described disease progression to liver failure. case: we here present a 26-year-old woman with history of congenital hiv on antiretroviral therapy complicated by pneumocystis carinii pneumonia at age 14. c ...	2017	28491877
low prevalence of pneumocystis pneumonia in hospitalized patients with systemic lupus erythematosus: review of a clinical data warehouse.	objective in the era of powerful immunosuppression, opportunistic infections are an increasing concern in systemic lupus erythematosus. one of the best-studied opportunistic infections is pneumocystis pneumonia; however, the prevalence of pneumocystis pneumonia in systemic lupus erythematosus is not clearly defined. this study evaluates the prevalence of pneumocystis pneumonia in hospitalized systemic lupus erythematosus patients, with a focus on validating the pneumocystis pneumonia and systemi ...	2017	28399687
multiple myeloma presenting with bilateral ankle pain (microangiopathy) and complicated by streptococcal meningitis and pneumocystis carinii pneumonia.	multiple myeloma is characterised by the neoplastic proliferation of a single clone of plasma cells producing a monoclonal immunoglobulin. this clone of plasma cells proliferates in the bone marrow, resulting in extensive skeletal destruction with osteolytic lesions, osteopenia and pathological fractures. additional disease-related complications include hypercalcaemia, renal insufficiency, anaemia and infection. we present the case of a 64-year-old woman presenting with rapid onset, painful dist ...	2017	28174184
overcoming hurdles to development of a vaccine against pneumocystis jirovecii.	development of pneumocystis pneumonia (pcp) is a common problem among immunosuppressed individuals. there are windows of opportunity in which vaccination would be beneficial, but to date, no vaccines have made it to clinical trials. significant hurdles to vaccine development include host range specificity, making it difficult to translate from animal models to humans. discovery of cross-reactive epitopes is critical to moving vaccine candidates from preclinical animal studies to clinical trials.	2017	28115507
immunization with pneumocystis cross-reactive antigen 1 (pca1) protects mice against pneumocystis pneumonia and generates antibody to pneumocystis jirovecii.	pneumocystis pneumonia (pcp) is a life-threatening infection that affects immunocompromised individuals. nearly half of all pcp cases occur in those prescribed effective chemoprophylaxis, suggesting that additional preventive methods are needed. to this end, we have identified a unique mouse pneumocystis surface protein, designated pneumocystis cross-reactive antigen 1 (pca1), as a potential vaccine candidate. mice were immunized with a recombinant fusion protein containing pca1. subsequently, c ...	2017	28031260
identification and characterization of novel rat polyomavirus 2 in a colony of x-scid rats by p-pit assay.	polyomaviruses (pyvs) are known to infect a wide range of vertebrates and invertebrates and are associated with a broad spectrum of diseases, including cancers, particularly in immune-suppressed hosts. a novel polyomavirus, designated rat polyomavirus 2 (ratpyv2), was identified from a breeding colony of rats having x-linked severe combined immunodeficiency. using a human panpolyomavirus immunohistochemistry test (p-pit), ratpyv2 was initially detected in the parotid salivary gland of a colony m ...	2017	28028546
differential macrophage polarization from pneumocystis in immunocompetent and immunosuppressed hosts: potential adjunctive therapy during pneumonia.	we explored differential polarization of macrophages during infection using a rat model of pneumocystis pneumonia. we observed enhanced pulmonary m1 macrophage polarization in immunosuppressed (is) hosts, but an m2 predominant response in immunocompetent (ic) hosts following pneumocystis carinii challenge. increased inflammation and inducible nitric oxide synthase (inos) levels characterized the m1 response. however, macrophage ability to produce nitric oxide was defective. in contrast, the lung ...	2017	27993972
fungal infection involvement in primary biliary cirrhosis: a review of 2 cases.	the present study aimed to analyze the imaging, clinical and pathological features of fungal infection involvement in primary biliary cirrhosis (pbc) by retrospectively analyzing and reviewing the features of two patients with fungal infection involvement in pbc. both patients were female. one patient had a confirmed diagnosis of pbc. the other patient had confirmed sjogren syndrome and pbc. the two cases of pbc were infected with fungal infection after treatment with hormonal and immunosuppress ...	2017	28352320
molecular diagnosis of pneumocystis pneumonia in dogs.	pneumocystis pneumonia (pcp) is a life-threatening fungal disease that can occur in dogs. the aim of this study was to provide a preliminary genetic characterisation of pneumocystis carinii f.sp.'canis' (p. canis) in dogs and thereby develop a reliable molecular protocol to definitively diagnose canine pcp. we investigated p. canis in a variety of lung specimens from dogs with confirmed or strongly suspected pcp (group 1, n = 16), dogs with non-pcp lower respiratory tract problems (group 2, n = ...	2017	28339756
the interaction of pneumocystis with the c-type lectin receptor mincle exerts a significant role in host defense against infection.	pneumocystis pneumonia (pcp) remains a major cause of morbidity and mortality within immunocompromised patients. in this study, we examined the potential role of macrophage-inducible c-type lectin (mincle) for host defense against pneumocystis binding assays implementing soluble mincle carbohydrate recognition domain fusion proteins demonstrated binding to intact pneumocystis carinii as well as to organism homogenates, and they purified major surface glycoprotein/glycoprotein a derived from the ...	2017	28298521