Publications

icsa surface presentation in shigella flexneri requires the periplasmic chaperones degp, skp, and sura.	a shigella flexneri degp mutant, which was defective for plaque formation in henle cell monolayers, had a reduced amount of icsa detectable on the bacterial surface with antibody. however, the mutant secreted icsa to the outer membrane at wild-type levels. this suggests that icsa adopts an altered conformation in the outer membrane of the degp mutant with reduced exposure on the cell surface. icsa is, therefore, unlikely to be accessible to actin-nucleating proteins within the eukaryotic cell cy ...	2007	17526712
[using neosmectin in the complex therapy of patients with acute intestinal infections].		2007	17539357
control and regulation of kple1 prophage site-specific recombination: a new recombination module analyzed.	kple1 is one of the 10 prophage regions of escherichia coli k12, located at 2464 kb on the chromosome. kple1 is defective for lysis, but it is fully competent for excisive recombination. in this study, we have mapped the binding sites of the recombination proteins, namely ints, tori, and ihf on attl and attr, and the organization of these sites suggests that the intasome is architecturally different from the lambda canonical form. we also measured the relative contribution of these proteins to b ...	2007	17545146
screening methods used to determine the anti-microbial properties of aloe vera inner gel.	the emergence of antibiotic resistant bacterial strains is a growing problem and is an important concern for patients, physicians, healthcare managers, and policymakers as it results in poorer health and economic outcomes. this has led to an urgent global call for new antimicrobial drugs, particularly from natural resources. we have been studying the antimicrobial properties of the inner leaf gel component of aloe barbadensis miller and have used a number of different, simple in vitro assays to ...	2007	17560318
the inner gel component of aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells.	the present study was carried out to examine the anti-inflammatory activity of the inner leaf gel component of aloe barbadensis miller. a simple in vitro assay was designed to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, namely tnf-alpha and il-1 beta, from peripheral blood leukocytes stimulated with shigella flexneri or lps. this report describes the suppression of both cytokines with a freeze-dried inner gel powder and a commercial health dri ...	2007	17560326
antimicrobial activity of a series of thiosemicarbazones and their zn(ii) and pd(ii) complexes.	thirty-four thiosemicarbazones and s-alkyl thiosemicarbazones, and some of their zn(ii) and pd(ii) complexes were obtained and purified to investigate antimicrobial activity. mic values of the compounds were determined by the disc diffusion method against escherichia coli, klebsiella pneumoniae, proteus mirabilis, pseudomonas aeruginosa, salmonella typhi, shigella flexneri, staphylococcus aureus, s. epidermidis, and candida albicans. the thiosemicarbazones show antibacterial and antifungal effec ...	2007	17571790
preparation and characterization of translocator/chaperone complexes and their component proteins from shigella flexneri.	shigella flexneri causes a severe form of bacillary dysentery also known as shigellosis. onset of shigellosis requires bacterial invasion of colonic epithelial cells which is initiated by the delivery of translocator and effector proteins to the host cell membrane and cytoplasm, respectively, by the shigella type iii secretion system (ttss). the shigella translocator proteins, ipab and ipac, form a pore complex in the host cell membrane to facilitate effector delivery; however, prior to their se ...	2007	17571858
a deafness-associated mutant human connexin 26 improves the epithelial barrier in vitro.	a large proportion of recessive nonsyndromic hearing loss is due to mutations in the gjb2 gene encoding connexin 26 (cx26), a component of a gap junction. within different ethnic groups there are specific common recessive mutations, each with a relatively high carrier frequency, suggesting the possibility of heterozygous advantage. carriers of the r143w gjb2 allele, the most prevalent in the african population, present with a thicker epidermis than noncarriers. in this study, we show that (r143w ...	2007	17581693
genetic structure of the nada and nadb antivirulence loci in shigella spp.	comparison of nada and nadb in 14 shigella strains and enteroinvasive escherichia coli versus e. coli showed that at least one locus is altered in all strains. these observations explain the characteristic nicotinic acid auxotrophy of shigella organisms and are consistent with the previously identified antivirulence nature of these genes for these pathogens.	2007	17586625
differences in the electrostatic surfaces of the type iii secretion needle proteins prgi, bsal, and mxih.	gram-negative bacteria use a needle-like protein assembly, the type iii secretion apparatus, to inject virulence factors into target cells to initiate human disease. the needle is formed by the polymerization of approximately 120 copies of a small acidic protein that is conserved among diverse pathogens. we previously reported the structure of the bsal needle monomer from burkholderia pseudomallei by nuclear magnetic resonance (nmr) spectroscopy and others have determined the crystal structure o ...	2007	17617421
distribution of serogroups and serotypes of multiple drug resistant shigella isolates.	summary	2007	17622331
site-specific modification of shigella flexneri virf mrna by trna-guanine transglycosylase in vitro.	shigella flexneri is an enteropathogen responsible for severe dysentery in humans. virf is a key transcriptional regulator that activates the expression of the downstream virulence factors required for cellular invasion and cell-to-cell spread of this pathogen. there are several environmental factors that induce the translation of virf including temperature, ph, osmolarity and post-transcriptional rna modification. durand and colleagues (vacc, a virulence-associated chromosomal locus of shigella ...	2007	17626052
study of predominant bacterial antigens triggering antibody response in salmonella reactive arthritis: apropos of a case.	reactive arthritis (rea) is a sterile arthritis triggered by distal mucosal infection, which suggests a contribution from bacterial products. the pathogenesis of rea is unclear. there are no international standards for the serological methods used to confirm rea. in the present work, we analyzed the predominant bacterial component that triggered an immune response in a 24-year-old woman with acute rea. the candidate bacterial trigger was investigated by measuring the antibacterial antibodies (al ...	2007	17642539
high prevalence of ctx-m-15 extended-spectrum beta-lactamase among contacts of patients with shigellosis due to shigella flexneri carrying ctx-m-15.		2007	17646198
anaerobic regulation of shigella flexneri virulence: arca regulates fur and iron acquisition genes.	invasion and plaque formation in epithelial monolayers are routinely used to assess the virulence of shigella flexneri, a causative agent of dysentery. a modified plaque assay was developed to identify factors contributing to the virulence of s. flexneri under the anaerobic conditions present in the colon. this assay demonstrated the importance of the ferrous iron transport system feo, as well as the global transcription factors fur, arca, and fnr, for shigella plaque formation in anoxic environ ...	2007	17660284
identification of minor inner-membrane components of the shigella type iii secretion system 'needle complex'.	type iii secretion systems (t3sss or secretons) are central virulence factors of many gram-negative bacteria, used to inject protein effectors of virulence into eukaryotic host cells. their overall morphology, consisting of a cytoplasmic region, an inner- and outer-membrane section and an extracellular needle, is conserved in various species. a portion of the secreton, containing the transmembrane regions and needle, has been isolated biochemically and termed the 'needle complex' (nc). however, ...	2007	17660405
the acid-resistance pathways of shigella flexneri 2457t.	the stationary-phase acid-resistance pathways of shigella flexneri 2457t have not previously been studied. the two acid-resistance systems, the glutamate-dependent acid-resistance (gdar) and the oxidative pathways, reported elsewhere for escherichia coli and s. flexneri 3136, were both detected in s. flexneri 2457t. however, s. flexneri 2457t cells grown overnight under fermentative conditions and acid-shocked in minimal media in the absence of glutamate, an acid test often described as a negati ...	2007	17660423
shigella flexneri phagosomal escape is independent of invasion.	infections with salmonella enterica serovar typhimurium and shigella flexneri result in mucosal inflammation in response to epithelial cell invasion and macrophage cytotoxicity. these processes are mediated by type iii secretion systems encoded in homologous virulence loci in the two species, namely, salmonella pathogenicity island 1 (spi-1), carried in the genome, and the shigella entry region (ser), carried in a large virulence plasmid. here we show that spi-1 can functionally complement a del ...	2007	17664266
genes under positive selection in escherichia coli.	we used a comparative genomics approach to identify genes that are under positive selection in six strains of escherichia coli and shigella flexneri, including five strains that are human pathogens. we find that positive selection targets a wide range of different functions in the e. coli genome, including cell surface proteins such as beta barrel porins, presumably because of the involvement of these genes in evolutionary arms races with other bacteria, phages, and/or the host immune system. st ...	2007	17675366
escherichia coli, shigella and salmonella species in acute diarrhoea in hamedan, islamic republic of iran.	this study investigated the frequency of escherichia col, shigella and salmonella species in stool specimens from patients with diarrhoea presenting to health centres in hamedan province, islamic republic of iran. from 144 samples, shigella strains were isolated in 17 cases (11.8%): 10 sh. flexneri, 3 sh. sonnei, 2 sh. boydii and 2 untyped strains. no salmonella strains were isolated. using molecular diagnostic methods, diarrheogenic e. coli were detected in 37 cases (25.7%), the majority were e ...	2007	17684844
[ekiri syndrome complicating shigellosis].		2007	17692219
[intrafamilial outbreak of shigella flexneri gastroenteritis in madrid].		2007	17692266
differential regulation of caspase-1 activation, pyroptosis, and autophagy via ipaf and asc in shigella-infected macrophages.	shigella infection, the cause of bacillary dysentery, induces caspase-1 activation and cell death in macrophages, but the precise mechanisms of this activation remain poorly understood. we demonstrate here that caspase-1 activation and il-1beta processing induced by shigella are mediated through ipaf, a cytosolic pattern-recognition receptor of the nucleotide-binding oligomerization domain (nod)-like receptor (nlr) family, and the adaptor protein apoptosis-associated speck-like protein containin ...	2007	17696608
omptin proteins: an expanding family of outer membrane proteases in gram-negative enterobacteriaceae.	the escherichia coli k-12 outer membrane protein ompt is a prototype of a unique family of bacterial endopeptidases known as the omptins. this family includes ompt and ompp of e. coli, sopa of shigella flexneri, pgte of salmonella enterica, and pla of yersinia pestis. despite their sequence similarities, the omptins vary in their reported functions. the ompt protease is characterized by narrow cleavage specificity defined by the extracellular loops of the beta-barrel protruding above the lipid b ...	2007	17710644
spontaneous zygogenesis, a wide-ranging mating process in bacteria.	spontaneous zygogenesis (or z-mating) in escherichia coli, unlike f-mediated conjugation, promotes formation of complete zygotes. most z-mating products have proven to be phenotypically unstable, losing part of the phenotype for which they were selected. persistent z-mating products appear as stable genetic recombinants or yield subclones of two types: either both parental types or one of them plus a recombinant type, and the ability to promote spontaneous zygogenesis can appear in all emerging ...	2007	17720456
an inducible lambdoid prophage encoding cytolethal distending toxin (cdt-i) and a type iii effector protein in enteropathogenic escherichia coli.	cytolethal distending toxins (cdts) are inhibitory cyclomodulins, which block eukaryotic cell proliferation and are produced by a diverse group of gram-negative bacteria, including escherichia coli strains associated with intestinal and extraintestinal infections. however, the mode of transmission of the toxin gene clusters among diverse bacterial pathogens is unclear. we found that cdt-i produced by enteropathogenic e. coli strains associated with diarrhea is encoded by a lambdoid prophage, whi ...	2007	17726095
intracellular type iii secretion by cytoplasmic shigella flexneri promotes caspase-1-dependent macrophage cell death.	the gram-negative bacterium shigella flexneri triggers pro-inflammatory apoptotic cell death in macrophages, which is crucial for the onset of an acute inflammatory diarrhoea termed bacillary dysentery. the mxi-spa type iii secretion system promotes bacterial uptake and escape into the cytoplasm, where, dependent on the translocator/effector protein ipab, caspase-1 [interleukin (il)-1beta-converting enzyme] and its substrate il-1beta are activated. here, we show that in the course of a macrophag ...	2007	17768231
ipad is localized at the tip of the shigella flexneri type iii secretion apparatus.	type iii secretion (t3s) systems are used by numerous gram-negative pathogenic bacteria to inject virulence proteins into animal and plant host cells. the core of the t3s apparatus, known as the needle complex, is composed of a basal body transversing both bacterial membranes and a needle protruding above the bacterial surface. in shigella flexneri, ipad is required to inhibit the activity of the t3s apparatus prior to contact of bacteria with host and has been proposed to assist translocation o ...	2007	17110044
enteropathogenic escherichia coli, shigella flexneri, and listeria monocytogenes recruit a junctional protein, zonula occludens-1, to actin tails and pedestals.	enteropathogenic escherichia coli, shigella flexneri, and listeria monocytogenes induce localized actin polymerization at the cytoplasmic face of the plasma membrane or within the host cytoplasm, creating unique actin-rich structures termed pedestals or actin tails. the process is known to be mediated by the actin-related protein 2 and 3 (arp2/3) complex, which in these cases acts downstream of neural wiskott-aldrich syndrome protein (n-wasp) or of a listerial functional homolog of wasp family p ...	2007	17118974
self-chaperoning of the type iii secretion system needle tip proteins ipad and bipd.	bacteria expressing type iii secretion systems (t3ss) have been responsible for the deaths of millions worldwide, acting as key virulence elements in diseases ranging from plague to typhoid fever. the t3ss is composed of a basal body, which traverses both bacterial membranes, and an external needle through which effector proteins are secreted. we report multiple crystal structures of two proteins that sit at the tip of the needle and are essential for virulence: ipad from shigella flexneri and b ...	2007	17077085
octaplex pcr and fluorescence-based capillary electrophoresis for identification of human diarrheagenic escherichia coli and shigella spp.	a multiplex pcr assay, amplifying seven specific virulence genes and one internal control gene in a single reaction, was developed to identify the five main pathotypes of diarrheagenic escherichia coli and shigella spp. the virulence genes selected for each category were stx1, stx2, and eaea for enterohemorrhagic e. coli (ehec), eaea for enteropathogenic e. coli (epec), stib and lti for enterotoxigenic e. coli (etec), ipah for enteroinvasive e. coli (eiec) and shigella spp., and aggr for enteroa ...	2007	17079041
o-acetylation in the o-specific polysaccharide isolated from shigella flexneri serotype 2a.	shigella flexneri causes diarrheal diseases especially in infants and children in developing countries. modifications of the lipopolysaccharide (lps) molecule, like bacteriophage-mediated glucosylation and acetylation of the o-specific chain (o-sp), are important for the lps antigenicity and consequently for the immunogenicity of the polysaccharide-based vaccines against shigellosis. here, we report the degree of o-acetylation and the localisation of o-acetyl groups and side-chain glucose substi ...	2007	17087926
cholesterol is required to trigger caspase-1 activation and macrophage apoptosis after phagosomal escape of shigella.	pro-inflammatory macrophage apoptosis is pivotal in the aetiology of bacillary dysentery, an acute inflammatory diarrhoea caused by shigella spp. s. flexneri triggers its uptake by macrophages, escapes the phagosome and kills the host cell by a cytotoxic pathway, which activates and requires caspase-1 [interleukin (il)-1beta-converting enzyme] and releases mature il-1beta. the bacterial type iii-secreted translocator/effector protein ipab triggers cell death and directly binds to caspase-1. here ...	2007	16925787
structural organization of the needle complex of the type iii secretion apparatus of shigella flexneri.	the secretion apparatus known as the needle complex (nc) from the bacterium shigella flexneri was studied by single particle electron microscopy. the isolated intact nc appears in projection to be composed of a basal body consisting of seven rings and a protruding needle appendage. a comparison of averaged projections of the intact nc and its fragments revealed the organization of the nc into several major subcomplexes. one of these lacks an inner membrane ring of the basal body but still presen ...	2007	16920362
socioeconomic correlates of antibody levels to enteric pathogens among israeli adolescents.	we examined the association between socioeconomic status and the level of serum antibodies to selected faeco-orally transmitted pathogens among israeli adolescents. random samples of eighty volunteers aged 12-15 years from high (hsl), medium (msl) and low (lsl) standard of living towns were included in the study. serum samples were examined by radioimmunoassay for hav and by in-house-developed elisa systems for iga and igg antibody levels against shigella sonnei, s. flexneri, e. coli o157:h7 lip ...	2007	16740193
[the diagnosis and method of surgical treatment in dislocation of the brain under the falx cerebri in craniocerebral trauma].	in 6.6% of cases a severe craniocerebral trauma is accompanied with dislocation of the brain under the falx cerebri with incarceration of the cingulate gyrus. the diagnosis of dislocation under the falx in intracranial traumatic hematoma and brain contusion-crushing is discussed. falxotomy may be among the methods for the prevention or correction of incarceration of the cingulate gyrus. the authors suggest an operative approach for performing falxotomy with little injury as well as a surgical in ...	2007	2168652
effects of dialysis membranes on beta 2-microglobulin production and cellular expression.	we investigated the effects of different dialysis membranes on the production of beta 2-microglobulin (beta 2m) in peripheral blood mononuclear cell cultures (pbmnc) obtained from hemodialysis patients in a prospective cross-over design study. chronic dialysis with cuprophane membrane leads to an increase in beta 2m production from 129 +/- 11 ng/ml to 192 +/- 23 ng/ml (p less than 0.002). this increase is reversed by the use of a non-complement activating membrane polymethylmethacrylate. in addi ...	2007	2266681
effects of dialysis membranes on beta 2-microglobulin production and cellular expression.	we investigated the effects of different dialysis membranes on the production of beta 2-microglobulin (beta 2m) in peripheral blood mononuclear cell cultures (pbmnc) obtained from hemodialysis patients in a prospective cross-over design study. chronic dialysis with cuprophane membrane leads to an increase in beta 2m production from 129 +/- 11 ng/ml to 192 +/- 23 ng/ml (p less than 0.002). this increase is reversed by the use of a non-complement activating membrane polymethylmethacrylate. in addi ...	2007	2266681
[clinical investigation of hepatectomies for hepatocellular carcinoma--significance of extended hepatectomy for advanced hepatocellular carcinoma].	although the diagnostic methods for hepatocellular carcinoma (hcc) are now being improved, there are still many cases detected at advanced stage. we, based on the redox theory and using a technique of vascular surgery and liver transplantation, made it possible to perform the extended hepatectomy more actively even in the advanced cases which were previously considered to be in-operable. we report these extended hepatectomies in this paper. from january 1985 to august 1989, we performed 263 hepa ...	2007	2168926
external fixators and their use.		2007	1941748
informed consent in dentistry: the impact of "who pays the bills?".	this paper analyzes the concept of informed consent in dentistry from a bioethical and philosophical perspective. it is my contention that informed consent, as presently utilized in daily dental practice, might be illusory at best. after analysis of the concept in general to derive a philosophical underpinning, this basis is applied to alternate delivery systems including medicaid, capitation programs, and the "overbilling" scenario. then an approach that is respectful of the patient's autonomy ...	2007	2634748
effects of inhaled and oral corticosteroids on bone.		2007	1867455
immediate and late inflammatory responses to ragweed antigen challenge of the peripheral airways in allergic asthmatics. cellular, mediator, and permeability changes.	asthma may represent the clinical manifestations of a unique form of chronic airway inflammation and is often associated with allergy. to better define the components of allergic inflammation in the lung, fluids obtained by bronchoalveolar lavage (bal) were examined for cells, inflammatory mediators, and markers of airway permeability 5 min and 19 h following instillation of ragweed antigen directly into an airway segment of allergic asthmatic subjects. the 5-min response to antigen challenge (n ...	2007	2064141
[hemodynamic and respiratory changes during laparoscopic cholecystectomy carried out under epidural anesthesia].		2007	1839167
alternating-pattern z-plasties in association with v-y advancements: a new idea of multiple z-plasties.	a new principle of arrangement in multiple z-plasties is advocated. by placing z's in an alternating pattern in combination with v-y plasties, more effective and harmless elongation of skin will be possible.	2007	1852835
electrolyte and water transport in the newt renal tubule due to the action of low-molecular fractions isolated from the intestine of the hibernating ground squirrel.	the micropuncture technique and x-ray microanalyses were used to evaluate na, k, ca, mg, cl and fluid transport in the early distal tubule mediated by low-molecular fractions isolated from the intestine of the hibernating ground squirrel (hsi). perfusion of intertubular capillaries with a solution containing hsi with a molecular weight of 1-10 kd (0.1 mg.ml-1) decreased the relative reabsorption of fluid, ca and mg. the other low-molecular fraction 1-10 kd of m.v. (0.1 mg.ml-1) isolated from the ...	2007	2150987
nomenclature of veins in the lower extremity.		2007	2048529
cognitive behavioural couples therapy with gay men referred for counselling in an aids setting: a pilot study.	counselling and psychological therapy is now an established part of health care in most aids settings, yet intervention has thus far tended to focus on the individual. it is argued that there is a need for greater development of therapy for couples in the aids field, based on the results of a pilot study of cognitive-behavioural couples therapy with 10 couples referred to a clinical psychologist working in an aids setting. results suggest that satisfaction with the relationship significantly imp ...	2007	2083260
[interferon in the treatment of hairy cell leukemia].		2007	2515708
[interferon in the treatment of hairy cell leukemia].		2007	2515708
role of ceramide as a lipid mediator of 1 alpha,25-dihydroxyvitamin d3-induced hl-60 cell differentiation.	the treatment of hl-60 myelocytic leukemia cells with 1 alpha,25-dihydroxyvitamin d3 (1,25-(oh)2d3) resulted in the activation of a neutral sphingomyelinase and in sphingomyelin turnover (okazaki, t., bell, r., and hannun, y. (1989) j. biol. chem. 264, 19076-19080). in this paper, the effects of 1,25-(oh)2d3 on the product of sphingomyelin hydrolysis, ceramide, and the possible function of ceramide as a lipid mediator of the effects of 1,25-(oh)2d3 on hl-60 cell differentiation were investigated ...	2007	2394750
essential fatty acids in the diet of rainbow trout (salmo gairdneri): lipid metabolism and fatty acid composition.		2007	5007121
use of gore-tex (polytetrafluoroethylene) in the anophthalmic socket.	the gore-tex soft tissue patch is composed of large open spaces surrounded by polytetrafluoroethylene (ptfe) fibers connected to nodules of solid ptfe. it was used in 12 oculoplastic surgery patients. primary and secondary spherical silicone implants were wrapped with a gore-tex patch and implanted into tenon's capsule. this study reports our first results using this versatile material.	2007	2248727
theophylline toxicity.		2007	1995754
[health indicators in urban areas. variations in function of social coherence of the geographic areas used].	the detection of health inequalities in the urban environment and their magnitude depends to a great extent on the internal social coherence of the geographical division used. using an existing social map of alicante which divides the city into basic units for social intervention (busi), we have compared the distribution of an indicator with wellknown relationship with the socio-economic level such as low birth weight, using both the busi and the municipal districts as analysis units. the data o ...	2007	2045222
the infrahyoid musculocutaneous flap in head and neck reconstruction.	the infrahyoid musculocutaneous flap (ihmf), as first described by wang in 1986, is mainly nourished by the superior thyroid vessels through the perforators of the infrahyoid muscles (i.e., sternohyoid muscle, sternothyroid muscle, superior belly of the omohyoid muscle). this thin flap, usually extending from the hyoid bone to the sternal notch at the central part of the anterior neck, provides a skin island of about 4 by 8 cm. after these muscles have been divided from their origins, the flap c ...	2007	1951898
annotated list of ticks (acari: ixodidae, argasidae) reported in peru: distribution, hosts, and bibliography.	a literature review and compilation of the tick specimens found in peru and now held in the national tick collection was carried out to develop a working list of the tick species likely to be found in peru. evidence of 44 species (29 ixodidae, 15 argasidae), was found; representatives of 40 species are held as reference specimens. this report adds 14 species to the previously published list.	2007	1941924
[the obstetric risk in adolescent primiparous females].	the obstetric risks in primiparae between 12 and 17 years of age have been reviewed in cases treated at our hospital from 1982 to 1987. we looked for intrauterine foetal deaths, premature deliveries (birth weight less than 2500 g), breech presentations, preeclampsia, caesarean sectio rate, forceps rate, and thirdstage complications. the risks found in the group of 476 young primiparae were compared to those amongst the 26,768 overall deliveries during the same period. the incidence of breech pre ...	2007	2737441
olfactory dysfunction in parkinson's disease.	an olfactory function test in 18 patients with parkinson's disease (pd) and 10 age-matched control subjects was performed. both detection and recognition thresholds were measured with five kinds of synthesized odorants (t & t olfactometry). before each test, rhinoscopic inspections were performed to exclude subjects who could have respiratory hyposmia. both detection and recognition thresholds in patients with pd were significantly elevated in comparison with those of control subjects. auditory ...	2007	1852411
replantation in children.	the authors have replanted 162 parts in 120 children over the past 15 years. the youngest patient, undergoing successful replantation, was aged 7 months, 3 weeks. unlike an adult, any child suffering a traumatic amputation should be considered for a possible replantation. replantation should consist of minimal bone shortening to preserve epiphyseal plates, with repair of all severed structures. longitudinal k-wires usually provide adequate fixation. our survival rate for complete replantation in ...	2007	1865815
illumination and errors in dispensing.	the relationship between the level of illumination and the prescription-dispensing error rate in a high-volume army outpatient pharmacy was investigated. the prescription error rate was determined by direct, undisguised observation and retrospective prescription review under three levels of illumination (45, 102, and 146 foot-candles) during 21 consecutive weekdays. illumination was controlled in the prescription-checking area of the pharmacy by using additional fluorescent lamps and filters. th ...	2007	1781468
an experience with diagnostic paracentesis in 100 cases of acute abdomen.	prognosis of acute surgical conditions of abdomen of both traumatic and non-traumatic origin depends on accurate diagnosis and early surgical intervention. however, the diagnosis in acute abdomen is quite difficult. the problem becomes more complex when 24 hours services of radiology and laboratories are not available. abdominal tap gives a valuable clue to diagnosis. a 10 ml syringe fitted with a 20 gauge intravenous needle was used for the purpose. both the flanks and the four quadrants of the ...	2007	2280070
imaging of chronic renal infections.		2007	2117344
effects of a diluent on the retarded-release property of acrylate methacrylate--salicylic acid coacervates.		2007	2293223
effects of a diluent on the retarded-release property of acrylate methacrylate--salicylic acid coacervates.		2007	2293223
fetal macrosomia in potential diabetics with normal oral glucose tolerance: a case control study.		2007	2223691
fetal macrosomia in potential diabetics with normal oral glucose tolerance: a case control study.		2007	2223691
mortality of a cohort of tin miners 1941-86.	the mortality patterns of united kingdom tin miners were examined in relation to calendar period and duration of underground work with particular attention to lung cancer and exposure to radon. subjects were all men who had worked for at least one year between 1941 and 1984 at one of two united kingdom tin mines and for whom a complete work history could be constructed from mine records. standardised mortality ratios (smrs) were calculated using national (england and wales) rates. the pattern of ...	2007	2223659
mortality of a cohort of tin miners 1941-86.	the mortality patterns of united kingdom tin miners were examined in relation to calendar period and duration of underground work with particular attention to lung cancer and exposure to radon. subjects were all men who had worked for at least one year between 1941 and 1984 at one of two united kingdom tin mines and for whom a complete work history could be constructed from mine records. standardised mortality ratios (smrs) were calculated using national (england and wales) rates. the pattern of ...	2007	2223659
differential scanning calorimetry study of mixed-chain phosphatidylcholines with a common molecular weight identical with diheptadecanoylphosphatidylcholine.	to examine the thermotropic phase behavior of various mixed-chain phosphatidylcholines in excess water and to compare it with the known behavior of identical-chain phosphatidylcholines, we have carried out high-resolution differential scanning calorimetric (dsc) studies on aqueous dispersions of 10 different mixed-chain phosphatidylcholines. these lipids, c(16):c(18)pc, c(18):c(16)pc, c(15):c(19)pc, c(19):c(15)pc, c(14):c(20)pc, c(20):c(14)pc, c(13):c(21)pc, c(21):c(13)pc, c(12):c(22)pc, and c(2 ...	2007	2223759
differential scanning calorimetry study of mixed-chain phosphatidylcholines with a common molecular weight identical with diheptadecanoylphosphatidylcholine.	to examine the thermotropic phase behavior of various mixed-chain phosphatidylcholines in excess water and to compare it with the known behavior of identical-chain phosphatidylcholines, we have carried out high-resolution differential scanning calorimetric (dsc) studies on aqueous dispersions of 10 different mixed-chain phosphatidylcholines. these lipids, c(16):c(18)pc, c(18):c(16)pc, c(15):c(19)pc, c(19):c(15)pc, c(14):c(20)pc, c(20):c(14)pc, c(13):c(21)pc, c(21):c(13)pc, c(12):c(22)pc, and c(2 ...	2007	2223759
[comparative evaluation of clinical and economic effectiveness of preventive therapy of affective and schizoaffective psychoses].	the authors provide the results of a comparative study into the action of different drug approaches to the prevention of relapses of affective and schizoaffective psychoses with the aid of multifactorial consideration of different clinical, economic and socioeconomic indicators characterizing the "benefits and losses" because of the use of carbamazepine and lithium carbonate. the comparative analysis has shown a high normothymic activity of carbamazepine and lithium carbonate in the patients exa ...	2007	2176049
[a case of pulmonary metastasis from adenoid cystic carcinoma of the trachea].	a 33-year-old woman with adenoid cystic carcinoma of the trachea was treated by resection of the upper and mid-trachea, plus total laryngectomy, subtotal thyroidectomy, partial resection of the cervical esophageal muscle layer and mediastinal tracheostomy. this tumor invaded directly into the thyroid gland, the larynx, the recurrent laryngeal nerve and the cervical esophagus. three years after the operation, metastases developed in the right lung (s10, s2) and partial resection of the lung was p ...	2007	2168922
[health care of immigrants].		2007	2375023
[pheochromocytoma diagnosed during quinapril therapy].	a hypertensive diabetic woman, who was resistant to any pharmacological therapy, underwent to check for secondary hypertension. the treatment with the particularly active ace inhibitor quinapril failed but it suggested a procedure for a fast differential diagnosis of disease.	2007	2074938
an analysis of maximum mandibular movements, craniofacial relationships and temporomandibular joint awareness in children.	this paper evaluates the relationship between maximum mandibular vertical opening and the following variables: chronological age, craniomandibular relationships, and temporomandibular joint awareness in children. the range of mandibular movement was evaluated in 189 children between the ages of 4 and 14 years, using the method of agerberg. measurements were found to be accurate and reliable only in the vertical plane. cephalometric tracings were made on 131 of the subjects. significant relations ...	2007	2064068
fiber digestion in the beaver.		2007	5007122
fiber digestion in the beaver.		2007	5007122
bibliography of the current world literature in hypertension.		2007	2168447
aberrant expression of intestinal mucin antigens associated with colorectal carcinoma defined by a panel of monoclonal antibodies.	small intestine mucin antigen (sima) is an oncofoetal antigen for the colon and is distinct from the normal large intestinal mucin antigen (lima). in the present study, a panel of anti-sima and anti-lima monoclonal antibodies (mab) was used to charaterise altered mucin expression in colorectal adenocarcinomas, by immunohistochemistry and quantitative immunoassays of tissue extracts. these results are compared with cea expression and correlated with various clinicopathological indices. all mucin ...	2007	1931599
bacteriological methods in diagnosis of tuberculous meningitis.		2007	3771495
esophageal function and dysfunction.		2007	1951923
hypertensive emergencies.	a hypertensive emergency is a rare event in which an acute elevation of blood pressure causes rapid progressive end-organ damage. cardiovascular, renal and central nervous system syndromes may be associated with acute blood pressure elevations. prompt treatment with antihypertensive agents should be initiated while the patient is closely monitored. lowering the blood pressure too quickly can exacerbate symptoms and decrease organ blood flow. treatment must be individualized depending on the end ...	2007	1950972
the effect of caffeine on postprandial blood pressure in the frail elderly.	in a double-blind, random-order, cross-over study the effects of placebo and 100 mg of caffeine on postprandial sitting and erect blood pressure and heart rate were studied in 20 frail elderly subjects (mean age 84, range 75-93 years) after a standardized 400 k-calorie glucose drink. maximal postprandial reduction in sitting systolic blood pressure occurred, at 60 minutes post-placebo, of - 11 mmhg (95% confidence interval -5 to -17 mmhg, p less than 0.01), and was attenuated by caffeine (p less ...	2007	1924023
intravenous immunoglobulin and pyridoxine-dependent seizures.		2007	1891109
soft fibroma-like lesions on the legs of a patient with kaposi's sarcoma and lymphedema.	the case of a patient who developed multiple soft fibroma-like lesions on his lower extremities affected by lymphedema and kaposi's sarcoma is reported. to the best of our knowledge, the coexistence of these three pathologic processes is unusual and has never been described before in the literature.	2007	1951987
distinction of mesothelioma from carcinoma in pleural effusions. an immunocytochemical study on routinely processed cytoblock preparations.	the study was designed to find out whether the commercially available antibodies bma 130 c, bma 120, v 9, kl 1, b 72.3 tag, hea 125 and ber-ep 4 would be of help in distinguishing carcinomas from a mesothelial process (mesothelioma/pleuritis) in pleural effusion specimens routinely processed by the cytoblock method. all of the 20 carcinomas included in the study but also 19 of the 20 mesotheliomas expressed cytokeratin (kl 1), whereas vimentin expression was found in 7 of the 20 carcinomas and 1 ...	2007	1876528
indigent health care in emergency medicine: an academic perspective.		2007	2064102
the battered nurse executive.		2007	2725981
gastric volvulus--a late complication of gastrostomy.	two cases of gastric volvulus are reviewed. both patients were nonverbal, mentally handicapped children, who were fed through a gastrostomy. they had intermittent intolerance to bolus feeds through the gastrostomy, accompanied by abdominal distension and vomiting of gastric contents. one had a previous partial fundoplication and gastrostomy, and the other had had two pyloroplasties and gastrostomy. the axis of torsion ran from the esophagogastric junction to the gastrostomy site. both children w ...	2007	1913395
a new manual method for assessing two-dimensional cancellous bone structure: comparison between iliac crest and lumbar vertebra.	we have developed a simple method for the direct analysis of two-dimensional trabecular structure. using this method, we have compared the structure of the left and right iliac crest and the second lumbar vertebra and studied the relationship between two-dimensional trabecular structure and the ultimate compressive stress of bone samples from the second lumbar vertebra. transverse cores were taken from the left and right iliac crests and second lumbar vertebrae of 35 subjects (12 females) who di ...	2007	1950674
[heterotopic pregnancy. a case report and review of the literature].	a case reported of simultaneous intrauterine and extrauterine pregnancy, is presented, accompanied by a spontaneous abortion, in the 8th week of gestation, and 3 weeks later, rupture of left tubal pregnancy. frequency and etiologic factors, as well as diagnostic possibilities are discussed.	2007	1797620
legal case briefs for nurses. or.: did nurse fail to call ambulance?; "hearsay evidence"; ga.: agency seeks injunction vs. former employee: "trade secret".		2007	1876706
body mass index variations: centiles from birth to 87 years.	this report provides body mass index (weight/height2) values for the french population from birth to the age of 87 years. bmi curves increase during the first year, decrease until the age of 6, increase again up to 65 years and decrease thereafter. these variations reflect the total changes of fat body mass during life. the 50th centile values of wt/ht2 at the ages of 20, 40, 60, 80 years are 21.5, 24.6, 25.4, 24.4 kg/m2 for men and 20.6, 22.6, 24.1, 23.4 kg/m2 for women. the values for the 3rd, ...	2007	1855495
compatibility of ciprofloxacin injection with selected drugs and solutions.	the compatibility of ciprofloxacin injection with selected antimicrobials and aminophylline was studied. ciprofloxacin, amikacin sulfate, aminophylline, clindamycin phosphate, gentamicin sulfate, and tobramycin sulfate were mixed separately in minibags containing 0.9% sodium chloride injection or 5% dextrose injection; admixtures were stored for up to 48 hours at either 4 degrees c or 25 degrees c. ciprofloxacin was also combined separately with each of the other drugs and solutions and stored u ...	2007	1781473
lauryl sulphate haemoglobin: a non-hazardous substitute for hicn in haemoglobinometry.	the haemiglobincyanide (hicn) method for measuring haemoglobin is used extensively worldwide; its advantage is the ready availability of a stable and internationally accepted reference standard/calibrator. however, its use may create a problem, especially in automated analysers, as the waste disposal of large volumes of reagent containing cyanide may constitute a potential toxic hazard. as an alternative, conversion of haemoglobin to a sulphate derivative by nontoxic sodium lauryl sulphate has b ...	2007	1794230
c1r subcomponent polymorphism in japanese: description of a new allele.	the polymorphism of c1r was investigated in 570 unrelated japanese individuals using isoelectric focusing and immunoblotting. a total of 11 different c1r phenotypes including a new pattern designated c1r 11-1 were observed. the allele frequencies were c1r1 = 0.4561, c1r2 = 0.3377, c1r5 = 0.1956, c1r8 = 0.0088 and c1rr (c1r9 and c1r11) = 0.0018. the population data fitted the hardy-weinberg equilibrium. the c1r polymorphism in japanese was shown to be controlled by 3 common alleles, c1r1, ...	2007	1855783
[scanning laser ophthalmoscopy. its value in macular diseases].	the scanning laser ophthalmoscope provided a high quality television image of the fundus with minimal illumination of the retina. this new device based on a totally new electro-optical principle allowed a detailed exploration of macular function directly under simultaneous fundus control. the focused beam of a yellow krypton laser (568,2 nm) was swept up and down, rights and links across the fundus to form a raster of parallel lines on the retina. the s.l.o. illuminated only a single retinal poi ...	2007	2258548
[scanning laser ophthalmoscopy. its value in macular diseases].	the scanning laser ophthalmoscope provided a high quality television image of the fundus with minimal illumination of the retina. this new device based on a totally new electro-optical principle allowed a detailed exploration of macular function directly under simultaneous fundus control. the focused beam of a yellow krypton laser (568,2 nm) was swept up and down, rights and links across the fundus to form a raster of parallel lines on the retina. the s.l.o. illuminated only a single retinal poi ...	2007	2258548
[successful therapy of ph1 positive chronic myelocytic leukemia with oral form of etoposide].	a 33-year-old female was diagnosed as having chronic myelocytic leukemia (cml) with philadelphia (ph1) chromosome and breakpoint cluster region (bcr) rearrangement. physical examination revealed a huge splenomegaly and laboratory data showed wbc 490 x 10(3)/microliter and nap score 44. she was treated with hydroxyurea, alpha-interferon, or busulfan, but severe adverse reaction such as skin rash, fever, and arthralgia, which allowed the therapy discontinue was occurred. when the patient was treat ...	2007	2255067