Publications

vertebral aspergillosis with preservation of the disc.		1977	338084
diagnosing allergic bronchopulmonay aspergillosis.		1977	338111
[prophylaxis of fungal contamination (author's transl)].	increased contamination by facultative pathogens such as coliforms and related gram-negative bacteria and candida albicans in hospital areas of risk endangers the benefits of medical care and causes great concern. the patient himself is the predominant source of nosocomial infections. furthermore the medical staff, ward personnel, and contaminated environment must be incriminated. by proper decontamination of certain groups of high-risk patients and of their surroundings as well as by interrupti ...	1977	339017
[bacterial and fungal rhino-sinusitis].		1977	339339
aspergillus pneumonia--a cluster of four cases in an intensive care unit.	four cases of aspergillus pneumonia occurred in an intensive care unit within a short period. clusters of cases of invasive aspergillosis are rare and have usually been attributed to excessive contamination of the environment. extensive environmental studies were, however, negative. three of the cases were diagnosed ante mortem. one patient survived after early initiation of treatment with amphotericin b.	1977	339374
[virulence and biochemical activity of aspergillus fumigatus strains isolated from cow fetuses].	tested was the virulence of 20 strains of aspergillus fumigatus isolated from cow fetuses. all laboratory mice injected with them died, and the pregnant guinea pigs aborted. it was demonstrated that these strains contain exogenic and endotoxic substances which are extracted effectively with alcohol and ether. the mould cultures showed proteolytic, amylolytic, cellulose, and organic acid activity. the biochemical and pathogenic potential of the strains were of great importance for causing abortio ...	1977	339512
occurrence of aspergillus fumigatus during composting of sewage sludge.	aspergillus fumigatus, a medically important fungal opportunist and respiratory allergen, was isolated from woodchips and sewage sludge used in the production of compost at the u.s. department of agriculture's composting research facility in beltsville, md. it was also regularly isolated as a dominant fungus during forced aeration composting and after 30 days in an unaerated stationary curing pile; in both cases, the fungus was found in pile zones with temperatures less than 60 degrees c. compos ...	1977	339835
treatment of fungal infections with miconazole.	the present study reports on 15 patients with confirmed or suspected secondary fungal infection, who were treated with intravenous miconazole and a daily dose of 0.4 to 28 g (mean 9.8 g). the mycological findings confirmed infection with aspergillus fumigatus in 6 patients and severe infection with candida albicans in 4. clinically mycological cures were achieved in 4 patients and some improvement was found in 3 others. the excellent patient tolerance of the drug makes it seem a likely treatment ...	1977	122648
experimental pulmonary aspergillosis in sensitized rabbits.		1977	142913
enzymatic release of iron from sideramines in fungi. nadh:sideramine oxidoreductase in neurospora crassa.	young mycelia of the fungus neurospora crassa contain a soluble nadh-linked sideramine reductase, which may be responsible for liberating iron in vivo from accumulated sideramines during iron-deficient cultivation. the enzymes can be assayed using a soluble supernatant fraction, edta, and an atmosphere of pure nitrogen. the enzyme is stable without loss of activity up to 45 degrees c and has an optimum of activity at ph 7.0. besides coprogen (km = 100 micrometer, v=2.8 nmol/min per mg protein), ...	1977	144535
circulating immune complexes and activation of the complement sequence in acute allergic bronchopulmonary aspergillosis.	a 13-yr-old asthmatic girl with allergic bronchopulmonary aspergillosis (abpa) exhibited eosinophilia, ige hypergammaglobulinemia, serum precipitins to aspergillus, a dual skin reaction to aspergillus fumigatus, and positive, lymphocyte transformation in vitro in response to stimulation with aspergillus fumigatus antigen. the acute phase of the disease was characterized by an increase in blood eosinophilia, a rise in serum ige, circulating immune complexes, and evidence of activation of the comp ...	1977	144747
relationship between proteolytic activity of aspergillus fumigatus and the fungus invasiveness of mouse brain.		1977	340955
natural occurrence of aspergillus fumigatus in cane sugar mills.	the environmental distribution of aspergillus fumigatus in 2 cane-sugar mills and one paper factory in northern india is compared with 2 localities in delhi. the preponderance of the species at the u.d. sugar mills, shamli, was contrary to its low prevalence in the university of delhi campus and at subzimandi, the vegetable and fruit market of delhi. aspergillus fumigatus accounted for 42.5% of the total aerial fungal colony counts recorded in the shamli mills as against 2% in delhi. the predomi ...	1977	341368
[experimental studies in animals on the influence of fluocortin butylester on the course of generalized infections (author's transl)].	the influence of butyl 6alpha-fluoro-11beta-hydroxy-16alpha-methyl-3,20-dioxo-1,4-pregnadien-21-oate (fluocortin butylester, vaspit), a new corticosteroidal compound with a marked dissociation between local antiinflammatory and systemic action, upon resistance against infections was studied in experimental bacterial and fungal infections in mice. the results of the experiments showed, that fluocortin butylester, even after repeated s.c. or oral administration of dosages up to 100 mg/kg did not d ...	1977	341900
treatment with antifungal vaccines.		1977	342190
[studies on the toxin of aspergillus fumigatus. viii. biological properties of asp-hemolysin (author's transl)].		1977	342741
[apropos of a case of invasive pulmonary aspergillosis with subadjacent aspergilloma].		1977	343198
cell-pool tryptophan levels during ergot alkaloid formation in aspergillus fumigatus.		1977	340382
"aspergillus fumigatus"--a pathogen and allergen.	aspergillus fumigatus is being increasingly recognised as causing various pathological conditions in man, animals and birds. in man the use of antibiotics has increased the importance of fungi in various clinical situations as opportunistic infective agents. in man, cavities in the lung are often (20 per cent) colonised by aspergillus species, nearly always a. fumigatus. the mycetoma so formed can be specifically diagnosed by finding precipitating antibodies to a. fumigatus in the serum. in an a ...	1977	345783
bilateral endogenous endophthalmitis successfully treated with 5-fluorocytosine.		1977	346120
mycotoxins produced by aspergillus fumigatus isolated from silage.	results are presented which show that aspergillus fumigatus was one of the predominant fungi contaminating moldy silage. growth of a. fumigatus on silage appeared to depend on a preliminary aerobic fermentation by other natural microflora in silage. the clavine alkaloid, fumigaclavine a, and a new clavine alkaloid designated fumigaclavine c were produced by a. fumigatus. the ld50 of fumigaclavine c was approximately 150 mg/kg oral dose in day-old cockerels.	1977	350117
fungal antigens as a source of sensitization and respiratory disease in scottish maltworkers.	mycological and serological studies were carried out as part of a survey of respiratory disease in scottish maltworkers. 70% of stained sputum smears from 574 workers showed the presence of higher plant cells and/or myclelia, and the spores of common environmental fungi. penicillium spp. (90%), rhizopus stolonifer (48%) and yeasts (53%) were the dominant fungi in 699 sputum cultures, and showed a similar proportional distribution in 327 samples of grain, malt, culms and dusts from fifty-six malt ...	1977	589785
fungus infection of ear.	of 2,632 patients seeking medical help for symptoms pertaining to the ear, 1,264 were clinically suspected to be suffering from fungus infection. microbiological confirmation of diagnosis was obtained in 209 cases including 82 cases with mixed infections (both fungus and bacteria). the commonest species of fungus isolated was aspergillus (aspergillus niger, 67%; aspergillus fumigatus, 24%). best results in fungus infection of the ear was obtained by daily packing of the external meatus by a wick ...	1977	615577
detection of aspergillus fumigatus precipitins: a comparison of counter immunoelectrophoresis and double diffusion.	a counter immunoelectrophoresis method was compared with a double diffusion test for detecting aspergillus fumigatus antibodies. of 70 patients, 23 gave positive results in both tests and the remainder gave negative results. fifteen patients with proven aspergillosis gave positive results in both tests.	1977	404338
the diagnosis of aspergillus fumigatus infection of the nasal chambers of the dog with particular reference to the value of the double diffusion test.		1977	404470
experimental aspergillosis in buffaloes: histopathological, histochemical and serological studies.		1977	405583
modified indirect fluorescent-antibody test for aspergillosis.	diffuse fluorescence in an indirect fluorescent-antibody test for antibody to aspergillus fumigatus was eliminated by using germlings, rather than hyphae, as antigen. the modified method yielded diagnostic titers larger than or equal to 1:32 in 24 of 25 known cases, was highly specific, and showed good correlation with clinical status and results of immunodiffusion. this technique, which uses the germling antigen, inactivation of test serum at 59 +/- 1 degrees c, and anti-immunoglobulin g conjug ...	1977	408374
variability of extracts used in immunoprecipitin tests.	immunodiffusion reactions of several different commercial fungal extracts from organisms were compared to those obtained from patients' environments. sera were obtained from patients suspected of having hypersensitivity lung disease (hld). there was a difference in reactivity among the sources of the antigen and in some lots of antigen from the same commercial supplier. the results demonstrate a wide variation in the reactivity of different antigenic extracts and emphasize the need for uniform s ...	1977	409751
opportunistic mycotic osteomyelitis: bone infections due to aspergillus and candida species.		1977	411015
clinical and therapeutic significance of patterns of allergic reactions of the lungs to extrinsic agents: the 1977 j. burns amberson lecture.		1977	411403
a comparative investigation of the bactericidal and fungicidal effects of three phenolic disinfectants.		1977	412825
sensitivity to 5-fluorocytosine and virulence for mice of some human isolates of aspergillus.	the sensitivity of 5-fluorocytosine (5-fc) and the virulence for mice was assessed for 16 human isolates of aspergillus: a. fumigatus 2, a. niger 7, a. flavus 4, a. terreus 2 and a. conicus (a. restrictus group) 1. fourteen strains were recovered from ear exsudates, 1 from sputum and 1 from the pus of mastoid cells of an autopsy case with meningeal and cerebral involvement. nine of them, which included strains of a. fumigatus and a. niger were sensitive to 5-fc (m.i.c. less than or equal to 6.4 ...	1977	413042
[mycologic study of the bronchial aspirates of patients with chronic lung diseases].		1977	414489
dual skin test reactions and serum antibodies to subtilisin and aspergillus fumigatus extracts.		1978	414857
a primate model of allergic bronchopulmonary aspergillosis.	allergic bronchopulmonary aspergillosis (aba) in man is featured by the presence of ige skin sensitizing and igg precipitating antibodies against aspergillus fumigatus (af). an animal model of this disease was created. 2 monkeys immunized with af produced igg-precipitating antibody. normal human serum was infused into both immunized and unimmunized monkeys and allergic human serum containing a high titer of ige against af was infused into another pair of immunized and unimmunized monkeys. all mo ...	1978	415985
culture and antigen variants of aspergillus.		1978	416063
specific double diffusion microtechnique for the diagnosis of aspergillosis and paracoccidioidomycosis using monospecific antisera.	using experimental reference sera against species-specific antigens of aspergillus fumigatus and paracoccidioides brasiliensis in a microdouble diffusion technique, a simple and specific test for the immunodiagnosis of aspergillosis and paracoccidioidomycosis has been developed. only sera that produced lines of identity with either one of the bands formed by the anti-c2 or the anti-e2 reference sera were considered positive for aspergillosis or paracoccidioidomycosis, respectively. the sensitivi ...	1978	416505
[pulmonary and hepatic aspergillomas in the deer].	four solitary aspergillomas in deer are being described. two were found in the lungs and two in the liver. morphologically, they were bulky, local lesions filled with homogenous, fragile, necrotic tissue of conspicuously green color. pulmonary aspergillomas communicated with the conducting bronchus having affected fibers. the necrotic tissue of aspergillomas was interwoven by diffuse abundant fibers of aspergillus fumigatus.	1978	416550
evaluation of methods to detect antibodies against aspergillus fumigatus.	seventy-five sera, including sera from 23 patients with aspergillosis, 17 with tuberculosis, asthma or carcinoma, and 35 normal controls, were studied for antibody activity against aspergillus fumigatus by agar gel double diffusion (dd), counterimmunoelectrophoresis (cie), indirect hemagglutination (iha) and indirect immunofluorescence (if). metabolic antigens produced from a selected strain of a. fumigatus were used for dd, cie and iha, while slide cultures of the same organism were used for if ...	1978	417619
[new toxins from aspergillus fumigatus fresenius].	a strain of aspergillus fumigatus fres., isolated from sugar-beet draffs, synthesizes in vitro four toxic metabolites which have not yet been described in these fungal species. toxic effects of the most abundant of these metabolites "fumitoxin a" have been studed on chick embryo. artemia salina larvae, cell cultures, and on mice.	1978	418904
some pulmonary manifestations of allergy.		1978	366356
experimental mycosis in immunosuppressed rabbits. ii. acute and chronic aspergillosis.	the influence of immunosuppression on the course of experimental aspergillosis was investigated. rabbits (2.2--2.5 kg) were divided into four groups. group one received no drugs and was given 10(6) spores intravenously (iv) or intratracheally (it) on two occasions one week apart. weight gain or loss, appearance or disappearance of aspergillus antigen and/or antibody, and detection of aspergillosis at autopsy were followed. group 2 received weekly injections of cyclophosphamide (70 mg/kg) startin ...	1978	366426
[presence of sexual forms (cleistothecia and hülle cells) in a case of human maxillary sinus aspergillosis caused by aspergillus nidulans in association with aspergillus fumigatus].	the authors observed, in a biopsic sample from a human maxillary sinus, the coexistence, in parasitic stages, of two different aspergillus species: a. fumigatus and a. nidulans. after having described the morphologies of each species, in sections on slides, and particularly those of cleistothecia and hülle-cells for the second, they draw attention to the three interests of such an observation: -- rarety of observing aspergillus nidulans in a parasitic stage, in spite of its particular thermotole ...	1978	366429
[treatment of severe forms of aspergillosis-related pneumonia].		1978	368427
fungal toxins as a parasitic factor responsible for the establishment of fungal infections.	although the mechanism of fungal infections, particularly that of opportunistic fungus infections, has been studied extensively, much still remains to be clarified. as is the case of certain bacterial infections, it has long been assumed by numerous investigators that some toxins, enzymes and other metabolites produced in vitro as well as in vivo by pathogenic fungi or their cellular constituents might be responsible for the establishment of fungal infections. however, there are very few papers ...	1978	370602
[two cases of pulmonary aspergilloma (author's transl)].		1978	373022
[pathomorphological studies of spontaneous and experimental abortions in cows and guinea pigs].	the morphologic studies of aspergillosis abortions in cows and guinea pigs were carried out on 83 spontaneously affected aborted cattle fetuses, pregnant guinea pigs and their offsprings. fifty-four fetuses were of spontaneously aborted cows from 12 farms along with 15 pregnant guinea pigs experimentally infected with aspergillus fumigatus and a total of 14 fetuses of theirs. microscopically, both in the cattle fetuses and in guinea pigs and their fetuses there were stasis, thrombosis, diapedeti ...	1978	369113
immunological aspects of infection and allergy due to aspergillus species.		1978	400877
mycotic infection of the paranasal sinuses.		1978	400886
[in vitro toxigenesis of aspergillus fumigatus strain. production of fumitoxins].	a new class of mycotoxins has been characterized from a strain of aspergillus fumigatus: the fumitoxins a, b, c and d. the in vitro production of these metabolites is studied. fumitoxins are common in cultures extracts of most strains of a. fumigatus. they are not detected from a. fischeri. variations of the levels of these products during the incubation of cultures, and also by using different media, are noted. at all events, the toxicity of crude extracts of the mould, for the chick embryo, is ...	1978	375091
aspergillus fumigatus and aspergillus niger in two potted ornamental plants, cactus (epiphyllum truncatum) and clivia (clivia miniata). biological and epidemiological aspects.	the presence and growth of aspergillus fumigatus and aspergillus niger in the soil of ornamental plants have been demonstrated. the ecological conditions in the soil of such plants as influenced by temperature, humidity, desiccation, fertilization and ventilation obviously influence such fungal growth. the epidemiological significance of these findings is of interest with a view to the present efforts to control aspergillosis in the environment of susceptible persons. observations of a preferent ...	1978	375093
a trial of isolating a tumor-like form of pulmonary cavities infected with aspergilli. ii. intra- and postoperative, morphologic and serologic data.	in ten specimens of resected pulmonary tissue, a little known and underscribed form of aspergillosis called tumor-like blocked pulmonary cavity with liquid content infected with aspergilli was observed. this designation was based on the finding in the specimens of tumor-like cavitary structures with blocked bronchus and contents from which abundant growth of aspergillus fumigatus was invariably obtained in cultures. nine of the ten specimens were bronchiectasis, and one was a bronchogenic cyst. ...	1978	389368
cellulose-decomposing fungi of salt marshes in egypt.	seventy-five species and three varieties which belong to thirty-four genera were identified from 74 soil samples collected from salt marshes in egypt. the most frequent fungi were aspergillus fumigatus, aspergillus niger, cladosporium herbarum and alternatia alternata, followed by aspergillus terreus, curvularia spicifera and penicillium notatum. six genera were of moderate occurrence: penicillium, fusarium, curvularia, rhizopus, stachybotrys, and chaetomium. five genera were of low occurrence: ...	1978	624509
allergic bronchopulmonary aspergillosis (abpa): studies on the general and specific humoral response.	serum specimens from 138 patients suffering from chronic respiratory disorders including 63 with allergic bronchopulmonary aspergillosis (abpa), 2o with suspected abpa, 15 with pulmonary tuberculosis, 14 with bronchial asthma, 10 with chronic bronchitis and 6 with miscellaneous pulmonary conditions were studied for circulating antibodies to aspergillus. the ammonium sulfate test was empolyed with an iodine-125 labeled mycelial component derived from aspergillus fumigatus. when compared to normal ...	1978	652026
invasive aspergillosis: antiserum for circulating antigen produced after immunization with serum from infected rabbits.	we describe a method for producing an antibody capable of detecting an antigen of aspergillus fumigatus in serum and urine from infected rabbits and humans.	1978	669813
in vitro studies with ambruticin, a new antifungal antibiotic.	the in vitro antifungal inhibitory activities of ambruticin and of various antifungal drugs of choice against 190 fungal pathogens representative of the major human mycoses were compared using a modification of the ics agar dilution technique. ambruticin compared favorably with amphotericin b and miconazole when tested against the dimorphic pathogens coccidioides immitis, histoplasma capsulatum, and blastomyces dermatitidis and against aspergillus fumigatus. miconazole was the most active compou ...	1978	686712
in vitro comparison of the antifungal activities of r34,000, miconazole and amphotericin b.	in vitro susceptibilities of 78 isolates of pathogenic filamentous fungi to the imidazole compounds r34,000 and miconazole and to amphotericin b were determined using an agar dilution technique. allescheria boydii, sporothrix schenckii and the dematiaceous fungi (cladosporium, fonsecaea and phialophora spp.) were most susceptible to miconazole with minimum inhibitory concentration (mic) values ranging from less than or equal to 0.25 to 32 microgram/ml and with geometric mean mic (g-mic) values o ...	1978	699677
[chronic septic granulomatosis imitating exogenic allergic alveolitis (farmer's lung)].	a 17-year-old boy demonstrated clinical and immunological signs of exogenic allergic alveolitis (farmer's lung). the patient grew up in the country and suffered from recurrent "pneumonia." in his serum precipitins were detected against micropolyspora faeni, aspergillus fumigatus and hay. transbronchially obtained lung tissue showed histologically an inflammation of the epitheloid-cell-granulomatous type with fibrosis. a congenital defect of the neutrophilic function was suspected in view of the ...	1978	700576
role of opportunistic fungi in ocular infections in nigeria.	the importance of opportunistic fungal pathogens in causing ocular infections is emphasized. a study was conducted over a period of 4 years (1974--1977) to investigate the role of opportunistic fungi in causing mycotic keratitis and to elucidate certain aspects of epidemiology of this disease in nigeria. fifty-nine cases of corneal ulcers of suspected mycotic etiology were investigated. fungal etiology was confirmed in 42 of these cases. the predominant etiological agent was fusarium solani in 1 ...	1978	745623
purification and properties of the polymeric fatty acid synthetase from a filamentous fungus.	fatty acid synthetase was purified from the filamentous fungus, aspergillus fumigatus to a specific activity of 4000--5000 munits/mg protein. its purity was established by its appearance in electron micrographs, on sodium dodecyl sulphate polyacrylamide gels and by analytical ultracentrifugation, and also by its behaviour upon sucrose gradient centrifugation. this enzyme comprises two large polypeptides with molecular weights of 190 000 and 186 000. evidence from electron microscopy indicates th ...	1978	350287
airborne aspergillus fumigatus levels outside and within a large clinical center.	most considerations of aspergillus fumigatus prevalence have implied that patterns of occurrence observed within london hospitals are generally applicable. since prevalence data are almost nonexistent elsewhere, this assumption remains untested. to provide a comparison relevant to north america, we have monitored thermotolerant fungi outside as well as at two sites within the university hospital, ann arbor, michigan, during one year. collections were made with paired andersen samplers and malt a ...	1978	350933
what does a fungus among us really mean?		1978	350935
a comparison of the prevalence of sensitization to aspergillus antigens among asthmatics in cleveland and london.	a survey of the frequency of sensitization to aspergillus antigens was conducted in a group of asthmatics in cleveland and compared with a group of asthmatics in london, using common antigens for testing purposes. the two groups were comparable except for earlier onset, longer duration of asthma, and a larger number of males in the london group. twenty-eight per cent of the asthmatics from cleveland and 23% from london had immediate skin reactivity to aspergillus. seven and one-half percent from ...	1978	350936
[a case of allergic bronchopulmonary aspergillosis (author's transl)].		1978	351105
[one-stage bilateral pulmonary resection in a case of bilateral aspergilloma of the lung].		1978	351582
allergic bronchopulmonary aspergillosis.	allergic bronchopulmonary aspergillosis (abpa) is not a common condition, even though asthma due to sensitization to aspergillus antigen is very common in many countries because of the ubiquitous distribution of the fungus itself. during the course of 14 years, the mycology department of the v. p. chest institute, delhi, has confirmed the diagnosis of abpa in 46 patients. the present study is based on the follow-up of 17 patients for understanding the evolution of the disease. all of them had as ...	1978	351756
cerebral aspergillosis following intracranial surgery. case report.	the authors report a case of cerebral aspergillosis. this is only the fifth case following intracranial surgery noted in the literature. pathogenesis, angiographic findings, and results of cerebrospinal fluid culture are discussed.	1978	353230
the role of precipitins in allergic lung disease.		1978	353417
pumonary aspergillosis during hospital renovation.	during a 4-week period, aspergillus fumigatus caused disease in 2 patients and colonized a third patient in a renal transplant ward. our investigation indicated that increased exposure of these patients to spores probably occurred during renovation of the ward one floor above it. cases were significantly clustered (p = 0.014) during the period when work overhead caused dust to filter down through pores in the acoustical tiles of the false ceiling of the renal transplant ward. swab cultures demon ...	1978	354445
therapeutic failures with miconazole.	a retrospective review of therapeutic failures of miconazole in three patients is presented. miconazole, a new imidazole derivative, is a broad-spectrum antifungal agent purportedly effective topically, orally, and parenterally against a number of species of fungi. three patients with the following culturally proven deep fungal infections were treated with miconazole: (i) destructive arthritis (sporothrix schenckii), (ii) meningoencephalitis (cryptococcus neoformans), and (iii) disseminated aspe ...	1978	354523
humoral and cellular immune responses in aspergillus fumigatus pulmonary disease.	this study was designed to evaluate immunologic differences between aspergilloma (a) and allergic bronchopulmonary aspergillosis (abpa), comparing the results to atopic and nonatopic control subjects. humoral studies included skin tests with common inhalant antigens and aspergillus fumigatus. total and specific ige and other immunologlobulin levels and serum precipitins were evaluated against a. fumigatus. cellular immunity was studied with routine skin testing and phytohemaqglutinin-induced lym ...	1978	355293
the use of fluorescein-labelled lectins in the detection and identification of fungi pathogenic for man: a preliminary study.	fluorescein-labelled lectins of known specificities for different sugars were used in an attempt to identify fungi in paraffin sections of surgical and post-mortem material. aspergillus fumigatus, blastomyces dermatitidis, candida albicans, cryptococcus neoformans, paracoccidioides brasiliensis and rhizopus oryzae have been studied with five fluorescein-labelled lectins and with basis of differences in their reactions with these stains. the results accord well with what is known of the chemistry ...	1978	355633
aspergillosis of the maxillary sinus.		1978	357140
the role of aspergillus fumigatus fresenius in dermatitis of chickens.	aspergillus fumigatus proved to be the causative organism of dermatitis in chickens. this has been assessed mycologically as well as histopathologically. the histopathological lesions caused by the fungi are fully described. the different factors which might help the establishment of the mycotic infection are discussed.	1978	357966
mycotic mastitis in two cows.		1978	358027
fumitoxins, new mycotoxins from aspergillus fumigatus fres.	extracts of cultures of aspergillus fumigatus isolated from silage were lethal to chicken embryos. using this test and thin-layer chromatography, four uv-absorbing toxins, designated as fumitoxins a, b, c and d, were isolated. analysis and mass spectrometry of crystallized fumitoxin a, the most abundant in the extract, established its molecular formula to be c31h42o8. infrared, uv spectroscopy, and chemical reactions suggested that fumitoxin a is a steroid. fumitoxins appear to be clearly differ ...	1978	358921
[description of a technic for the detection of aspergillus fumigatus antibodies in extrinsic allergic alveolitis].		1978	358999
[determination of aspergillus fumigatus toxins by thin layer chromatography].		1978	359584
rapid germination of aspergillus fumigatus conidia in mouse kidneys and a kidney extract.	intravenously injected conidia of aspergillus fumigatus germinated rapidly in the kidneys of untreated and cortisone-treated specific-pathogen-free (spf) mice and in the livers of cortisone-treated spf mice. extracts of kidneys from untreated and cortisone-treated mice stimulated germination of a. fumigatus conidia in vitro. the possible roles of a germination stimulant and host defences in the kidney localisation of a. fumigatus infection are discussed.	1978	360442
a clinical environmental study of the aeroallergens of the islands of bermuda.	the major allergen responsible for allergic respiratory disease in the islands of bermuda has been shown to be derived from dermatophagoides pteronyssinus. 73% of the atopic group included in the survey gave weal and erythema reactions to extracts of this mite, whereas only 30% reacted to mixed pollen extracts and 10% to mould extracts. d. pteronyssinus was isolated from all house dust samples and it represented nature, with only a modest seasonal influence, and pollen counts were low throughout ...	1978	361282
fungal spores in lung and sputum.	a survey of fungal aerospora over a 2-year period was combined with an investigation of the fungi cultured from 295 samples of peripheral human lung and 2466 samples of sputum over the same period. 83% of lung and 88% of sputum samples contained culturable fungi, although in 16% of lung and 31% of sputum samples candida albicans was the only one. those fungi of small spore size tended to be found in lung tissue while those with larger spores were more likely to be found in the sputum. while thei ...	1978	361283
the diagnostic value of antibodies to the traditional antigens of farmer's lung in finland.	precipitating antibodies towards antigens associated with farmer's lung disease were studied in finnish dairy farming and non-farming rural populations and the results were compared to those of serum samples of patients suspected of having a fungal allergy. the antigen panel consisted of aspergillus fumigatus, micropolyspora faeni and thermoactinomyces vulgaris. all three microbes seemed to be important environmental inducers of antibody formation. the prevalence of antibodies towards all of the ...	1978	361284
[a meningoencephalitic form of cerebral aspergillosis effectively treated with a derivative of berberine alkaloids (author's transl)].		1978	361324
[antifungal properties of paste used for local treatment of fungal lung diseases].		1978	362381
[studies on air pollution by fungal spores at selected working posts at a paper factory].		1978	362382
a case of abortion in rabbit due to aspergillus fumigatus infection.		1978	362693
unusual manifestations of pulmonary aspergillosis.	pulmonary aspergillosis is being diagnosed with increasing frequency, particularly in larger referral centers. the spectrum of lung pathology can be classified into 3 major groups: a) non-invasive mycetoma; b) allergic bronchopulmonary aspergillosis and c) invasive aspergillosis. five patients with pulmonary aspergillosis are presented, illustrating unusual features of each major group. transthoracic needle aspiration biopsy was diagnostic in 3 patients. it is important to differentiate a myceto ...	1978	363725
aspergillus infection in a patient receiving immunosuppressive drugs.	a rare case of an indolent aspergillus infection in a deep neck space in an immunologically compromised patient is reported. aggressive measures were taken to identify the cause of the infection. despite concerted antifungal therapy, the patient died.	1978	363984
invasion of a bronchial carcinoma by aspergillus fumigatus.		1978	364761
[occurrence of aspergillus fumigatus in west berlin - contribution to the epidemiology of aspergillosis (author's transl)].	the increasing incidence of human a. fumigatus infections particularly such of the respiratory tract has led to this study of the epidemiological situation. during the period between october 1968 and december 1977, a. fumigatus was isolated from clinical material in 425 cases. these findings which were established at the mycology unit, robert koch institute, federal health office, exhibited the following distribution by regions of the body or type of specimen: respiratory tract 277 (65.1(); veno ...	1978	364887
cystic fibrosis, atopy, and airways lability.	in a survey of cystic fibrosis (cf) in the avon area, 48 children with cf from 40 families together with 71 of their parents were studied by spirometry, exercise tests, and pinch tests. a control group of 42 young adults was similarly tested; control data for children were taken from previously published work. the prevalence of atopy (any positive prick test) in children with cf was 48%. sensitivity to grass pollens and house dust mite was no more common in these children (29%) than in a normal ...	1978	365112
subunit composition of fatty acid synthetase from fungi.		1978	346409
damage to hyphal forms of fungi by human leukocytes in vitro. a possible host defense mechanism in aspergillosis and mucormycosis.	evidence suggests that neutrophils are important in host defenses against invasive aspergillosis and mucormycosis, although hyphae in these lesions are too large to be phagocytized. interactions of neutrophils with hyphae of aspergillus fumigatus and rhizopus oryzae were studed in vitro. light and electron microscopic observations indicated that neutrophils attached to and spread over the surfaces of hyphae, even in the absence of serum. this was followed by dramatic morphologic changes which su ...	1978	347942
sequential cold-sensitive mutations in aspergillus fumigatus.	mutants of thermotolerant fungus aspergillus fumigatus i-21 (atcc 32722) unable to grow at 37 degrees c were sought. cold-sensitive mutants were enriched from progeny spores of gamma-irradiated conidia by two or more incubations at various nonpermissive temperatures alternating with filtrations through chessecloth. the approximate minimum, optimum, and maximum growth temperatures of the parent were 12, 40, and 50 degrees c, respectively. mutants unable to grow at 37 degrees c were not successful ...	1978	348279
precipitating factors in respiratory allergic disease in indonesian children.	skin test results and ige antibody levels measured by rast indicate that hypersensitivity to house dust mite (d. pteronyssinus) is a major feature of asthma and allergic rhinitis in indonesian children. total serum ige levels were higher in the allergic than in control children. 60% (twenty-one out of thirty-five) of the asthmatic children and 56% (five out of nine) of the children with allergic rhinitis had ige antibodies to the helminth ascaris lumbricoides compared with none out of four contr ...	1978	348344
specific ige estimations by rast in japanese asthmatics compared with skin, passive transfer and bronchial provocation tests.	198 asthmatics and twenty healthy persons were studied by rast and in vivo tests with four common inhalant allergens. (a) higher rast classes were elicited with mite (dermatophagoides farinae) extract and lower classes with other allergens. the agreement between positive rast and skin or p-k tests was highest with the mite extract. rast sensitivity was dependent on the kinds of allergens and was most sensitive to mite extract. positive rast was most closely related to the prick test reactions. ( ...	1978	348345
serum ige and igg antibody activity against aspergillus fumigatus as a diagnostic aid in allergic bronchopulmonary aspergillosis.	serum ige and igg antibody activity against aspergillus fumigatus was measured in 3 groups of subjects by 2 different immunologic methods. group a consisted of 23 patients with allergic bronchopulmonary aspergillosis (abpa). group b was composed of 19 patients with extrinsic asthma who had marked immediate type skin reactivity to a. fumigatus (prick skin test, 3 or 4+) but no other manifestation of abpa. group c, the control group, was composed of 12 healthy subjects. two immunological methods, ...	1978	350109
collection and cultivation of and phagocytosis by pulmonary macrophages obtained from hysterectomy-derived pigs.	methods were developed for procuring phagocytically active macrophages from porcine lung with minimal damage to respiratory tissues. procedures included anesthetizing, surgically introducing a t-shaped tracheal catheter, and repeatedly flushing the respiratory tract. macrophages collected in this manner were characterized as to numbers, types, and phagocytic activity, nonselective lavage of the pulmonary airways of unstimulated and stimulated (evoking agent: thioglycolate medium) animals yielded ...	1978	345891
diagnosis of invasive pulmonary aspergillosis by fiberoptic transbronchial lung biopsy.		1978	340719
"fruiting bodies" of aspergillus on the skin of a burned patient.	a case of a young man with an extensive total-body-surface burn complicated by wound infection is presented. one of the fungal organisms in the cutaneous burn wound had morphologically characteristic and diagnostic features by development of conidiophores ("fruiting bodies") pathognomonic of aspergillus spp.	1978	343572