Publications

chemopreventive and therapeutic effects of curcumin.	chemoprevention is a promising anti-cancer approach with reduced secondary effects in comparison to classical chemotherapy. curcumin, one of the most studied chemopreventive agents, is a natural compound extracted from curcuma longa l. that allows suppression, retardation or inversion of carcinogenesis. curcumin is also described as an anti-tumoral, anti-oxidant and anti-inflammatory agent capable of inducing apoptosis in numerous cellular systems. in this review, we describe both properties and ...	2005	15896452
alpha-glucosidase inhibition of natural curcuminoids and curcumin analogs.	natural curcumin (1), demethoxycurcumin (2) and bisdemethoxycurcumin (3) isolated from curcuma longa (turmeric), and synthetic curcumin analogs (a(1-7), b(1-7), c(1-6) and d(1-7)) were evaluated in vitro for the alpha-glucosidase inhibitory activity via uv and circular dichroism (cd) spectroscopy. the results indicated that natural curcuminoid compound 3 showed a remarkable inhibitory effect with ic(50) of 23.0 microm, and the synthetic compounds a(2), b(2), c(2) and d(2) showed potent inhibitor ...	2006	16387392
regulation of inflammation and redox signaling by dietary polyphenols.	reactive oxygen species (ros) play a key role in enhancing the inflammation through the activation of nf-kappab and ap-1 transcription factors, and nuclear histone acetylation and deacetylation in various inflammatory diseases. such undesired effects of oxidative stress have been found to be controlled by the antioxidant and/or anti-inflammatory effects of dietary polyphenols such as curcumin (diferuloylmethane, a principal component of turmeric) and resveratrol (a flavonoid found in red wine). ...	2006	16920072
biosynthesis of curcuminoids and gingerols in turmeric (curcuma longa) and ginger (zingiber officinale): identification of curcuminoid synthase and hydroxycinnamoyl-coa thioesterases.	members of the zingiberaceae such as turmeric (curcuma longa l.) and ginger (zingiber officinale rosc.) accumulate at high levels in their rhizomes important pharmacologically active metabolites that appear to be derived from the phenylpropanoid pathway. in ginger, these compounds are the gingerols; in turmeric these are the curcuminoids. despite their importance, little is known about the biosynthesis of these compounds. this investigation describes the identification of enzymes in the biosynth ...	2006	16890967
physical properties of a new denture lining material containing a fluoroalkyl methacrylate polymer.	a new fluoride-containing, methacrylate-based denture lining material has been introduced. because of the fluoride content, this material is expected to demonstrate low water sorption and solubility and high stain resistance, but these attributes remain untested.	2006	16872931
multiple biological activities of curcumin: a short review.	turmeric (curcuma longa rhizomes), commonly used as a spice is well documented for its medicinal properties in indian and chinese systems of medicine. it has been widely used for the treatment of several diseases. epidemiological observations, though inconclusive, are suggestive that turmeric consumption may reduce the risk of some form of cancers and render other protective biological effects in humans. these biological effects of turmeric have been attributed to its constituent curcumin that h ...	2006	16413584
curcumin, an atoxic antioxidant and natural nfκb, cyclooxygenase-2, lipooxygenase, and inducible nitric oxide synthase inhibitor: a shield against acute and chronic diseases.	the world suffers a tsunami of chronic diseases, and a typhoon of acute illnesses, many of which are associated with the inappropriate or exaggerated activation of genes involved in inflammation. finding therapeutic agents which can modulate the inflammatory reaction is the highest priority in medical research today. drugs developed by the pharmaceutical industry have thus far been associated with toxicity and side effects, which is why natural substances are of increasing interest.	2006	28059012
biological effects of curcumin and its role in cancer chemoprevention and therapy.	curcumin, a natural component of the rhizome of curcuma longa has emerged as one of the most powerful chemopreventive and anticancer agents. its biological effects range from antioxidant, anti-inflammatory to inhibition of angiogenesis and is also shown to possess specific antitumoral activity. the molecular mechanism of its varied cellular effects has been studied in some details and it has been shown to have multiple targets and interacting macromolecules within the cell. curcumin has been sho ...	2006	16712454
effects of oxygen and turmeric on the formation of oxidative aldehydes in fresh-pack dill pickles.	hexanal, pentanal, and heptanal were found to be normal components of commercially processed, fresh-pack dill pickles. hexanal and pentanal were present at concentrations severalfold higher than their odor detection thresholds. these aldehydes were also found in pickles that were packed in the laboratory under anaerobic conditions. injection of oxygen into pickles prepared in anaerobic conditions resulted in the production of increasing the amounts of hexanal, heptanal, and pentanal. hexanal, pe ...	2006	16637703
an efficient protocol for genetic transformation and shoot regeneration of turmeric (curcuma longa l.) via particle bombardment.	turmeric (curcuma longa l.) is an important spice crop plant that is sterile and cannot be improved by conventional breeding. an efficient method for stable transformation for turmeric, c. longa l., was developed using particle bombardment. callus cultures initiated from shoots were bombarded with gold particles coated with plasmid pahc25 containing the bar and gusa genes each driven by the maize ubiquitin promoter. transformants were selected on medium containing glufosinate. transgenic lines w ...	2006	16397786
multiple molecular targets in cancer chemoprevention by curcumin.	carcinogenesis encompasses 3 closely associated stages: initiation, progression, and promotion. phytochemicals are nonnutritive components of plants that are currently being studied in chemoprevention of various diseases for their pleiotropic effects and nontoxicity. cancer chemoprevention involves the use of either natural or synthetic chemicals to prevent the initiation, promotion, or progression of cancer. curcumin is the active constituent of turmeric, which is widely used as a spice in indi ...	2006	17025261
curry consumption and cognitive function in the elderly.	curcumin, from the curry spice turmeric, has been shown to possess potent antioxidant and antiinflammatory properties and to reduce beta-amyloid and plaque burden in experimental studies, but epidemiologic evidence is lacking. the authors investigated the association between usual curry consumption level and cognitive function in elderly asians. in a population-based cohort (n = 1,010) of nondemented elderly asian subjects aged 60-93 years in 2003, the authors compared mini-mental state examinat ...	2006	16870699
antioxidant therapeutic targets in copd.	oxidative stress and chronic inflammation are important features in the pathogenesis of chronic obstructive pulmonary disease (copd). oxidative stress has important consequences for several elements of lung physiology and for the pathogenesis of copd, including oxidative inactivation of antiproteases and surfactants, mucus hypersecretion, membrane lipid peroxidation, alveolar epithelial injury, remodeling of extracellular matrix, and apoptosis. therefore, targeting oxidative stress with antioxid ...	2006	16787173
microemulsion electrokinetic chromatography for separation and analysis of curcuminoids in turmeric samples.	microemulsion ekc (meekc) was developed for quantitative analysis of curcuminoids, such as curcumin (c), demethoxycurcumin (d), and bis-demethoxycurcumin (b). meekc separation of curcuminoids was optimized, and a change in resolution was explained using a modified equation for resolution in meekc without electroosmosis. the suitable meekc conditions for separation of curcuminoids were obtained to be the microemulsion buffer containing 50 mm phosphate buffer at ph 2.5, 1.1% v/v n-octane as oil dr ...	2006	16605086
turmeric extracts containing curcuminoids prevent experimental rheumatoid arthritis.	turmeric has been used for centuries in ayurvedic medicine as a treatment for inflammatory disorders including arthritis. on the basis of this traditional usage, dietary supplements containing turmeric rhizome and turmeric extracts are also being used in the western world for arthritis treatment and prevention. however, to our knowledge, no data are available regarding antiarthritic efficacy of complex turmeric extracts similar in composition to those available for use as dietary supplements. th ...	2006	16562833
dose escalation of a curcuminoid formulation.	curcumin is the major yellow pigment extracted from turmeric, a commonly-used spice in india and southeast asia that has broad anticarcinogenic and cancer chemopreventive potential. however, few systematic studies of curcumin's pharmacology and toxicology in humans have been performed.	2006	16545122
curcumin mediates ceramide generation via the de novo pathway in colon cancer cells.	a wealth of evidence supports the notion that curcumin, a phytochemical present in turmeric, is a potent chemopreventive agent for colon cancer. its mechanism of action remains incompletely understood. here we report that curcumin's apoptosis-inducing effects in colon cancer cell lines are accompanied by robust ceramide generation. this occurs through de novo synthesis as the increase in ceramide could be attenuated by pre-incubation of the cells with myriocin, and no changes were observed in sp ...	2006	16501251
use of liquid chromatography-electrospray ionization tandem mass spectrometry to identify diarylheptanoids in turmeric (curcuma longa l.) rhizome.	lc-esi-ms/ms coupled to dad analysis was used as an on-line tool for identification of diarylheptanoids in fresh turmeric rhizome extracts. based on their mass spectra, from both negative and positive mode lc-esi-ms/ms analysis, and supported by their dad spectra, 19 diarylheptanoids were identified. among these 19 compounds, curcumin, demethoxycurcumin, and bisdemethoxycurcumin were identified by comparing their chromatographic and spectral data with those of authentic standard compounds. the o ...	2006	16490201
curcumin maintenance therapy for ulcerative colitis: randomized, multicenter, double-blind, placebo-controlled trial.	curcumin is a biologically active phytochemical substance present in turmeric and has pharmacologic actions that might benefit patients with ulcerative colitis (uc). the aim in this trial was to assess the efficacy of curcumin as maintenance therapy in patients with quiescent ulcerative colitis (uc).	2006	17101300
dietary antioxidant curcumin inhibits microtubule assembly through tubulin binding.	curcumin, a component of turmeric, has potent antitumor activity against several tumor types. however, its molecular target and mechanism of antiproliferative activity are not clear. here, we identified curcumin as a novel antimicrotubule agent. we have examined the effects of curcumin on cellular microtubules and on reconstituted microtubules in vitro. curcumin inhibited hela and mcf-7 cell proliferation in a concentration-dependent manner with ic(50) of 13.8 +/- 0.7 microm and 12 +/- 0.6 micro ...	2006	17069615
chili, but not turmeric, inhibits iron absorption in young women from an iron-fortified composite meal.	chili and turmeric are common spices in indigenous diets in tropical regions. being rich in phenolic compounds, they would be expected to bind iron (fe)(3) in the intestine and inhibit fe absorption in humans. three experiments were conducted in healthy young women (n = 10/study) to assess the effect of chili and turmeric on fe absorption from a rice-based meal containing vegetables and iron fortified fish sauce in vivo. iron absorption was determined by erythrocyte incorporation of stable isoto ...	2006	17116705
in vitro inhibition of lipid peroxidation in fish by turmeric (curcuma longa).	the beneficial effects of ∈-3 fatty acids on human health have been well documented. fish and fish oils are the richest sources of ∈-3 fatty acids. however, due to their high degree of unsaturation, they are highly susceptible to lipid peroxidation. regular consumption of peroxidised oils may represent a risk factor for the induction and development of atherosclerosis. in view of the above reports, it was considered necessary to study the effects of tumeric on fish lipid peroxidation during stan ...	2006	23105631
tpa-induced up-regulation of activator protein-1 can be inhibited or enhanced by analogs of the natural product curcumin.	the activator protein-1 (ap-1) family of transcription factors, including the most common member c-jun-c-fos, participates in regulation of expression of numerous genes involved in proliferation, apoptosis, and tumorigenesis in response to a wide array of stimuli including pro-inflammatory cytokines, growth factors, stress, and tumor promoters. a number of plant polyphenols including curcumin, a yellow compound in the spice turmeric, have been shown to inhibit the activation of ap-1. curcumin is ...	2006	16934760
curcumin content of turmeric and curry powders.	curcumin, derived from the rhizome curcuma longa, is one of the primary ingredients in turmeric and curry powders that are used as spices in middle eastern and asian countries, especially on the indian subcontinent. more recently, laboratory studies have demonstrated that dietary curcumin exhibits various biological activities and significantly inhibits colon tumorigenesis and tumor size in animals. curcumin displays both anti-inflammatory and antioxidant properties, giving it the potential to b ...	2006	17044766
efficient preparation of liposomes encapsulating food materials using lecithins by a mechanochemical method.	in order to evaluate to the feasibility of using lecithins for nanocapsules including functional food materials, liposomes were prepared from different commercially available lecithins (slp-white, slp-pc70 and pl30s) by the bangham method, and their physicochemical properties were examined by using a confocal laser scanning microscopy (clsm) and the measurements of trapping efficiency. there was little difference in the trapping efficiency among the three types of liposomes. in all cases, the tr ...	2006	17693697
contact urticaria from curcumin.	turmeric, a spice derived from the rhizome of the plant curcuma longa, contains the chemical curcumin, which is responsible for turmeric's taste, color, and biologic properties. curcumin is used as a spice in foods, as a treatment in traditional medicine, as a dye for fur, and as a component in nutritional supplements. a few cases of allergic contact dermatitis from curcumin have been reported. we report two cases of contact urticaria from curcumin. these cases are mediated by two different mech ...	2006	17150169
metabolic profiling of turmeric (curcuma longa l.) plants derived from in vitro micropropagation and conventional greenhouse cultivation.	turmeric (curcuma longa) was considered only a culinary spice in many parts of the world until the notable anti-inflammation curcuminoids were discovered from this herb. because it is a sterile triploid and is propagated vegetatively by rhizome division, turmeric is susceptible to pathogens that accumulate and are transmitted from generation to generation, and amplification of particularly useful stocks is a slow process. an in vitro propagation method has been developed to alleviate these probl ...	2006	17147448
lifespan extension by the antioxidant curcumin in drosophila melanogaster.	the interest in health benefits associated with consumption of anti-oxidants has led to investigations examining the possibility that diets rich in anti-oxidants promote lifespan extension. studies using the standard fruit fly (drosophila melanogaster) model of longevity have shown that the antioxidants vitamin e and n-acetyl cysteine prolong lifespan. turmeric is a spice which has been consumed and used for medicinal purposes for many centuries in asia. interestingly, turmeric contains the powe ...	2006	23675008
molecular orbital basis for yellow curry spice curcumin's prevention of alzheimer's disease.	it is demonstrated by using high-level ab initio computations that the yellow curcumin pigment, bis-(4-hydroxy-3-methoxyphenyl)-1,6-diene-3,5-dione, in the east indian root plant turmeric (curcuma longa) exhibits unique charge and bonding characteristics that facilitate penetration into the blood-brain barrier and binding to amyloid beta (abeta). alzheimer's disease is caused by abeta accumulation in the brain cells combined with oxidative stress and inflammation. consistent with the recent expe ...	2006	19127718
molecular targets of dietary agents for prevention and therapy of cancer.	while fruits and vegetables are recommended for prevention of cancer and other diseases, their active ingredients (at the molecular level) and their mechanisms of action less well understood. extensive research during the last half century has identified various molecular targets that can potentially be used not only for the prevention of cancer but also for treatment. however, lack of success with targeted monotherapy resulting from bypass mechanisms has forced researchers to employ either comb ...	2006	16563357
distribution of metals in the edible plants grown at jajmau, kanpur (india) receiving treated tannery wastewater: relation with physico-chemical properties of the soil.	the implications of metal contamination of agricultural soils due to long term irrigation with treated industrial wastewater and their subsequent accumulation in the vegetables/crops growing on such soils has been assessed in an area of industrial complex, jajmau, kanpur (india). physico-chemical properties of the soil were also studied. the soil and vegetables/crops were sampled from an area of 2100 acre agricultural land and analyzed for physico-chemical properties and metal accumulation in di ...	2006	16502026
protection by turmeric and myrrh against liver oxidative damage and genotoxicity induced by lead acetate in mice.	the effects of lead acetate in the diet (0.5% w/w) on reduced gsh, activity of phase ii metabolizing enzyme glutathione s-transferase (gst), lipid peroxidation in liver homogenate and bone marrow chromosomes of mice simultaneously supplemented with powdered turmeric and myrrh for 8 weeks were investigated. five groups of swiss male albino mice, each of 30 mice, the first group received a basal diet and served as negative control, the second group received basal diet supplemented with lead acetat ...	2006	16433888
effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol on the biofilm formation of streptococcus mutans.	colonization on the surface of tooth by streptococcus mutans is an important step in the initiation of dental plaque. polystyrene microtiter plates have been employed to study bacterial colonization and biofilm formation of periodontal bacteria. the objective of this work was to evaluate the effect of coating the wells of a polystyrene microtiter plate with xanthorrhizol isolated from java turmeric (curcuma xanthorrhiza roxb.) on strep. mutans biofilm formation. our studies demonstrated that coa ...	2006	17009296
effects of ingested turmeric oleoresin on glucose and lipid metabolisms in obese diabetic mice: a dna microarray study.	turmeric, the rhizome of curcuma longa l., has a wide range of effects on human health. turmeric oleoresin, an extract of turmeric, is often used for flavoring and coloring. curcuminoids and turmeric essential oil are both contained in turmeric oleoresin, and both of these fractions have hypoglycemic effects. in the present study, we comprehensively assessed the effect of turmeric oleoresin on hepatic gene expression in obese diabetic kk-ay mice using dna microarray analysis and quantitative rea ...	2006	17117790
mechanisms of curcumin- and egf-receptor related protein (errp)-dependent growth inhibition of colon cancer cells.	numerous dietary and pharmacological agents have been proposed as alternative strategies for treatment and prevention of colorectal cancer. curcumin, an active ingredient of turmeric, that inhibits growth of malignant neoplasms, has a promising role in the prevention and treatment of colorectal cancer. egf-r related protein (errp), a recently identified pan-erbb inhibitor, is a potential therapeutic agent for colorectal cancer. here we examine whether curcumin together with errp will cause a gre ...	2006	17044774
turmeric and curcumin modulate the conjugation of 1-naphthol in caco-2 cells.	turmeric, the powdered dry rhizome of the curcuma longa plant, and curcumin, the major anti-oxidant constituent of turmeric, have been shown to possess chemopreventive activity. to elucidate the possible interaction of turmeric and curcumin with conjugation reactions, which in many cases are involved in the activation of procarcinogens, we measured their effects in the conjugation of 1-naphthol in caco-2 cells, a human colon carcinoma cell line, within a 24 h period. turmeric exhibits inhibitory ...	2006	16819192
curcumin inhibits telomerase activity in human cancer cell lines.	curcumin, one of the major components of tumeric, the dried rhizome of curcuma longa l, has been shown to have anti-proliferating and anti-carcinogenic properties. in this study, we examined the effects of curcumin on cell growth and telomerase activity in human cancer cell lines bel7402, hl60 and sgc7901. curcumin (1-32 microm) showed anti-proliferating effects on these cell lines in a dose-dependent manner in vitro, and anti-tumor effects when curcumin (50-200 mg/kg) was orally administered to ...	2006	16820928
effects of capsaicin, dihydrocapsaicin, and curcumin on copper-induced oxidation of human serum lipids.	the oxidation of low-density lipoprotein (ldl) is believed to be the initiating factor for the development and progression of atherosclerosis. the active ingredients of spices such as chili and turmeric (capsaicin and curcumin, respectively) have been shown to reduce the susceptibility of ldl to oxidation. one of the techniques used to study the oxidation of ldl is to isolate ldl and subject it to metal-induced (copper or iron) oxidation. however, whole serum may represent a closer situation to ...	2006	16910741
curcumin activated both receptor-mediated and mitochondria-mediated proteolytic pathways for apoptosis in human glioblastoma t98g cells.	the therapeutic effect of curcumin (ccm), a polyphenolic compound from the rhizome of curcuma longa, has not yet been examined in glioblastoma. we used human glioblastoma t98g cells to explore the efficacy of ccm for inducing apoptosis and identifying proteolytic mechanisms involved in this process. trypan blue dye exclusion test showed decrease in cell viability with increasing dose of ccm. wright staining and apoptag assay showed, respectively, morphological and biochemical features of apoptos ...	2006	16949208
curcumin, the active principle of turmeric (curcuma longa), ameliorates diabetic nephropathy in rats.	chronic hyperglycaemia in diabetes leads to the overproduction of free radicals and evidence is increasing that these contribute to the development of diabetic nephropathy. among the spices, turmeric (curcuma longa) is used as a flavouring and colouring agent in the indian diet every day and is known to possess anti-oxidant properties. the present study was designed to examine the effect of curcumin, a yellow pigment of turmeric, on renal function and oxidative stress in streptozotocin (stz)-ind ...	2006	17002671
study on effects of extracts from salvia miltiorrhiza and curcuma longa in inhibiting phosphorylated extracellular signal regulated kinase expression in rat's hepatic stellate cells.	to study the effect of salvianolic acid b (sab) and curcumin, the extracts of salvia miltiorrhiza and curcuma longa, on the proliferation and activation of hepatic stellate cell (hsc), and the extracellular signal regulated kinase (erk) expression in it.	2006	17005083
curcumin reverses the effects of chronic stress on behavior, the hpa axis, bdnf expression and phosphorylation of creb.	curcuma longa is a major constituent of the traditional chinese medicine xiaoyao-san, which has been used to effectively manage stress and depression-related disorders in china. curcumin is the active component of curcuma longa, and its antidepressant effects were described in our prior studies in mouse models of behavioral despair. we hypothesized that curcumin may also alleviate stress-induced depressive-like behaviors and hypothalamic-pituitary-adrenal (hpa) axis dysfunction. thus in present ...	2006	17022948
modulation of the function of the multidrug resistance-linked atp-binding cassette transporter abcg2 by the cancer chemopreventive agent curcumin.	curcumin (curcumin i), demethoxycurcumin (curcumin ii), and bisdemethoxycurcumin (curcumin iii) are the major forms of curcuminoids found in the turmeric powder, which exhibit anticancer, antioxidant, and anti-inflammatory activities. in this study, we evaluated the ability of purified curcuminoids to modulate the function of either the wild-type 482r or the mutant 482t abcg2 transporter stably expressed in hek293 cells and drug-selected mcf-7 flv1000 and mcf-7 advp3000 cells. curcuminoids inhib ...	2006	16928820
tetrahydrocurcumin: effect on chloroquine-mediated oxidative damage in rat kidney.	tetrahydrocurcumin is an antioxidative substance, which is derived from curcumin, the component of turmeric. in the present investigation, the effect of tetrahydrocurcumin and curcumin against chloroquine-induced nephrotoxicity were studied in female wistar rats. oral administration of tetrahydrocurcumin significantly prevented the occurrence of chloroquine (970 mg/kg body weight)-induced renal damage. upon administration of tetrahydrocurcumin to chloroquine-treated rats, the level of lipid pero ...	2006	17076682
curcumin targets akt cell survival signaling pathway in htlv-i-infected t-cell lines.	the akt signaling pathway is important for survival and growth of cancer cells. in the present paper we show that the akt signaling pathway is constitutively activated in human t-cell leukemia virus type i (htlv-i)-infected t-cell lines and in primary adult t-cell leukemia (atl) cells. curcumin, a natural compound present in turmeric, has been studied vigorously as a potent chemopreventive agent for cancer therapy because of its inhibitory effect on proliferation and induction of apoptosis in se ...	2006	16630125
safety and efficacy of nt, an herbal supplement, in treating human obesity.	a human pilot study testing the safety and effectiveness of nt (number ten), a dietary herbal supplement made from rhubarb, ginger, astragulus, red sage and turmeric, to reduce food intake and cause weight loss.	2006	16652135
developmental therapeutics: review of biologically based cam therapies for potential application in children with cancer: part i.	this article is a review of the status of biologically based complementary and alternative medicine (cam) therapies that have potential anticancer activity with a focus on those agents that may be active in childhood cancer. the review presented in 2 parts includes the descriptions of the mechanisms that underlie their effects, the manner by which these agents are identified and evaluated and discussion of some of the limitations of current research. the first part introduces the topic of biolog ...	2006	16679919
curcumin inhibits hypoxia-induced angiogenesis via down-regulation of hif-1.	hypoxia-inducible factor-1 (hif-1) has a central role in cellular responses to hypoxia, including the transcriptional activation of a number of genes involved in angiogenesis in tumors. we found that curcumin, a natural, biologically active compound isolated from the commonly used spice turmeric, significantly decreases hypoxia-induced hif-1alpha protein levels in hepg2 hepatocellular carcinoma cells. moreover, curcumin suppressed the transcriptional activity of hif-1 under hypoxia, leading to a ...	2006	16685395
curcumin combats against cigarette smoke and ethanol-induced lipid alterations in rat lung and liver.	human population, in spite of the medical and scientific achievements, still fall as a prey to the evils of habitual smoking and alcohol, thus necessitating safer counteracting measures. objective: to evaluate the effect of cotreatment of curcumin (curcuma longa) in rats subjected to acute exposure to cigarette smoke (cs) and ethanol (etoh).	2006	16691314
resistance to apoptosis of hcw-2 cells can be overcome by curcumin- or vincristine-induced mitotic catastrophe.	the term mitotic catastrophe has recently become widely used to describe a form of death affecting many cancer cells, which, because of severe dna or mitotic spindle damage, are not able to bypass mitosis. we show here that cells of the hl-60-derived hcw-2 line highly resistant to apoptosis, upon treatment with curcumin or vincristine, undergo mitotic catastrophe that is finalized by caspase 3 activation and oligonucleosomal dna degradation. curcumin is a natural dye, derived from curcuma longa ...	2006	16721786
scabies.	scabies is a neglected parasitic disease that is a major public health problem in many resource-poor regions. it causes substantial morbidity from secondary infections and post-infective complications such as acute post-streptococcal glomerulonephritis. disease control requires treatment of the affected individual and all people they have been in contact with, but is often hampered by inappropriate or delayed diagnosis, poor treatment compliance, and improper use of topical compounds such as per ...	2006	16731272
down-regulation of prostaglandin e2 by curcumin is correlated with inhibition of cell growth and induction of apoptosis in human colon carcinoma cell lines.	several in vitro and in vivo studies have demonstrated an association between curcumin, a diferuloylmethane derived from the plant curcuma longa, and colorectal cancer (crc) prevention. nevertheless, the molecular mechanism responsible for the chemopreventive effect of curcumin is not well understood and most probably involves several pathways. several studies indicate that curcumin may exert its effect by specifically inhibiting the cyclooxygenase-2 (cox-2) isoenzyme, which is up-regulated in 4 ...	2006	16737669
effect of curcumin on protein glycosylation, lipid peroxidation, and oxygen radical generation in human red blood cells exposed to high glucose levels.	curcumin (diferuloylmethane) is the most active component of turmeric. it is believed that curcumin is a potent antioxidant and anti-inflammatory agent. experimental studies with diabetic animals demonstrate that curcumin supplementation can suppress cataract development and collagen cross-linking, promote wound healing, and lower blood lipids and glucose levels. the mechanism by which curcumin may cause diabetes-associated vascular damage to regress is not known. erythrocytes were treated with ...	2006	16781457
curcumin's biphasic hormetic response on proteasome activity and heat-shock protein synthesis in human keratinocytes.	curcumin (diferuloylmethane), is a component of the yellow powder prepared from the roots of curcuma longa (zingiberaceae), also known as tumeric or turmeric. it is widely cultivated and used as a food ingredient in tropical areas of asia and central america. treatment of mid-passage human epidermal keratinocytes with curcumin resulted in a biphasic hormetic dose-response with respect to proteasome activity. curcumin treatment (up to 1 microm for 24 h) increased chymotrypsin-like activity by 46% ...	2006	16804017
modulation of cytokine expression by traditional medicines: a review of herbal immunomodulators.	modulation of cytokine secretion may offer novel approaches in the treatment of a variety of diseases. one strategy in the modulation of cytokine expression may be through the use of herbal medicines. a class of herbal medicines, known as immunomodulators, alters the activity of immune function through the dynamic regulation of informational molecules such as cytokines. this may offer an explanation of the effects of herbs on the immune system and other tissues. for this informal review, the aut ...	2006	16813462
curcumin inhibits the mammalian target of rapamycin-mediated signaling pathways in cancer cells.	curcumin (diferuloylmethane), a polyphenol natural product of the plant curcuma longa, is undergoing early clinical trials as a novel anticancer agent. however, the anticancer mechanism of curcumin remains to be elucidated. here we show that curcumin inhibited growth of rhabdomyosarcoma cells (rh1 and rh30) (ic50 = 2-5 microm) and arrested cells in g1 phase of the cell cycle. curcumin also induced apoptosis and inhibited the basal or type i insulin-like growth factor-induced motility of the cell ...	2006	16550606
cumulative antioxidant defense against oxidative challenge in galactose-induced cataractogenesis in wistar rats.	natural dietary ingredients are known for their antioxidant activity. of such, curcumin, the active principle of turmeric, at 0.01% in the diet proved as pro-oxidative in galactose-induced cataract in vivo. the purpose of this study was to investigate the effect of vitamin e (ve), a well-known antioxidant, in combination with curcumin on the onset and maturation of galactose induced cataract. periodic slit-lamp microscope examination indicated that in combination with vitamin-e, 0.01% curcumin ( ...	2006	16999028
effect of bitter gourd and spent turmeric on constituents of glycosaminoglycans in different tissues in streptozotocin induced diabetic rats.	diet is now one of the well established means in the management of diabetes. bitter gourd and spent turmeric at 10% level were tested for their efficacy on glycosaminoglycan metabolism in various tissues viz., liver, spleen, lungs, heart and testis in control, diabetic and treated rats. the glycosaminoglycans (gags) were isolated from defatted and dried tissues. the contents of sulfated gags decreased in all the tissues and the decrease was more prominent in heart and testis. in the isolated gag ...	2006	16532259
dosage effects of curcumin on cell death types in a human osteoblast cell line.	curcumin, the yellow pigment of curcuma longa, is known to have antioxidant and anti-inflammatory properties, as well as their ability to either induce or prevent cell apoptosis. however, the precise molecular mechanisms of these effects are unknown. here, we demonstrate that curcumin can induce apoptotic changes, including jnk activation, caspase-3 activation, and cleavage of parp and pak2, at treatment concentrations lower than 25 microm in human osteoblast cells. in contrast, treatment with 5 ...	2006	16624471
curcumin potently blocks kv1.4 potassium channels.	curcumin, a major constituent of the spice turmeric, is a nutriceutical compound reported to possess therapeutic properties against a variety of diseases ranging from cancer to cystic fibrosis. in whole-cell patch-clamp experiments on bovine adrenal zona fasciculata (azf) cells, curcumin reversibly inhibited the kv1.4k+ current with an ic50 of 4.4 microm and a hill coefficient of 2.32. inhibition by curcumin was significantly enhanced by repeated depolarization; however, this agent did not alter ...	2006	16647042
field evaluation of deet, repel care, and three plant based essential oil repellents against mosquitoes, black flies (diptera: simuliidae) and land leeches (arhynchobdellida: haemadipsidae) in thailand.	diethyl methyl benzamide, or deet, a commercial plant-based repellent (repel care), and essential ils from 3 species of plants (finger root rhizomes, guava leaves, and turmeric rhizomes), steam distillated and formulated as insect repellents, were evaluated in the field on human volunteers against hematophagous mosquitoes, black flies, and land leeches in thailand. field trials were conducted against wild mosquitoes in bang bua thong district, nonthaburi province, and in the thap lan national pa ...	2006	17019778
ethanolic extracts from curcuma longa attenuates behavioral, immune, and neuroendocrine alterations in a rat chronic mild stress model.	the ethanolic extracts from the rhizome of curcuma longa l. (turmeric), possesses a wide variety of biological activities related to the treatment and prevention of affective disorders. to study their antidepressant effects, the impacts of chronic mild stress (cms) and of the subsequent administration of ethanolic extracts of c. longa were investigated. male sprague-dawley rats subjected to the cms procedure demonstrated increased serum interleukin-6 and tumor necrosis factor-alpha levels, as we ...	2006	16651723
cytotoxic effect of curcumin on giardia lamblia trophozoites.	giardia lamblia is one of the most important worldwide causes of intestinal infections produced by protozoa. thus, the search for new alternative therapeutic approaches for this parasitic disease is very important. common drugs used to control and eradicate this infection, frequently exhibit side effects that force patients to abandon treatment. the present work evaluates the anti-protozoan activity of curcumin, the main constituent of turmeric. axenic g. lamblia (portland 1 strain) cultures wer ...	2006	16678115
inhibition of homodimerization of toll-like receptor 4 by curcumin.	toll-like receptors play a key role in sensing microbial components and inducing innate immune responses. ligand-induced dimerization of tlr4 is required for the activation of downstream signaling pathways. thus, the receptor dimerization may be one of the first lines of regulation in activating tlr-mediated signaling pathways and induction of subsequent immune responses. lps induces the activation of nf-kappab and irf3 through myd88- or trif-dependent pathways. curcumin, a polyphenol found in t ...	2006	16678799
salmonella prevalence and total microbial and spore populations in spices imported to japan.	a total of 259 samples of 40 types of spices were tested for salmonella prevalence and total microbial and spore populations. salmonella enterica serotypes weltevreden and senftenberg were isolated from a black- and red-pepper sample, respectively. because salmonella was not detected by the most-probable-number method, it indicated that at least one cell of the microorganism was present in 25 g of sample. the mean aerobic bacterial count was greater than 5.39 log cfu/g in turmeric, garam masala, ...	2006	17066938
antimicrobial emulsion (coating) based on biopolymer containing neem (melia azardichta) and turmeric (curcuma longa) extract for wound covering.	polymeric bio-adhesives emulsion which is biodegradable and non-toxic containing antimicrobial agents can play an important role in preventing infection in wound covering and coating for surgical implants. therefore a bioadhesive polymer was synthesized by semi-interpenetrating network process using blend of shellac, casein and polyvinyl alcohol and maleic anhydride (ma) as reactive compatibilizer. the synthesized polymer was mixed with neem and turmeric extract and homogenized using an emulsifi ...	2006	17075168
antitumor action of curcumin in human papillomavirus associated cells involves downregulation of viral oncogenes, prevention of nfkb and ap-1 translocation, and modulation of apoptosis.	curcumin (diferuloyl methane), the major yellow pigment from the rhizomes of turmeric (curcuma longa linn), has anticancer properties. infection with high-risk human papillomaviruses (hpv) leads to development of cervical carcinoma, predominantly through the action of viral oncoproteins e6 and e7. the present study aims at analyzing the antitumor and antiviral properties of curcumin, on hpv associated cervical cancer cells. our findings indicate curcumin to be cytotoxic to cervical cancer cells ...	2006	16526022
curcumin analogs as potent aldose reductase inhibitors.	in the present study, curcuminoids isolated from curcuma longa were demonstrated to possess inhibitory activities on bovine lens aldose reductase. in order to find more potent aldose reductase inhibitor, curcumin analogs were synthesized and evaluated for their ability to inhibit bovine lens aldose reductase enzyme. the results indicated that the compounds with tetrahydroxyl groups, 2,6-bis(3,4-dihydroxybenzylidene)cyclohexanone (a(2)), 2,5-bis(3,4-dihydroxybenzylidene)cyclopentanone (b(2)), 1,5 ...	2006	16528793
inhibitory effect of thai plant extracts on p-glycoprotein mediated efflux.	curcuminoids from curcuma longa l. and extracts of psidium guajava l., andrographis paniculata (burm. f.) nees, phyllanthus emblica l. and solanum trilobatum l. were investigated for their inhibitory effect on p-glycoprotein (p-gp) on the efflux transport of rhodamine 123 (rho-123 ) in caco-2 cells and rat ileum. of the five tested samples, curcuminoids and an extract of p. guajava showed the highest inhibitory effect on p-gp mediated efflux of rho-123 in caco-2 cells. additionally, they were fo ...	2006	16397849
induction of g2/m arrest and inhibition of cyclooxygenase-2 activity by curcumin in human bladder cancer t24 cells.	curcumin, a polyphenol compound derived from curcuma longa linn, has been recognized as a promising anti-cancer drug due to its multiple properties including anti-inflammatory, anti-oxidant and anti-carcinogenic activities. to elucidate the mechanisms by which curcumin inhibits human bladder carcinoma t24 cell proliferation, we tested the effects of curcumin on specific cell cycle pathways and on the expression of cyclooxygenases (coxs). curcumin inhibited the growth of t24 cells and induced g2/ ...	2006	16596191
curcumin inhibits cell migration of human colon cancer colo 205 cells through the inhibition of nuclear factor kappa b /p65 and down-regulates cyclooxygenase-2 and matrix metalloproteinase-2 expressions.	curcumin (diferuloylmethane) is a chemical derived from several curcuma species (turmeric), possessing anti-inflammatory and antioxidant properties and which, thus, may be a potential anticancer drug. however, its mechanism of action is not fully understood. our previous studies had shown that curcumin induced cytotoxicity, cell cycle arrest and apoptosis in human colon cancer colo 205 cells. in this study, curcumin affected the levels of nf-kappab/ p65 in a time-dependent manner but did not aff ...	2006	16619535
opposing action of curcumin and green tea polyphenol in human keratinocytes.	persistent environmental insult can convert a normal cell into a cancer cell. however, various natural chemopreventive agents called antioxidants can retard this progression. we have recently explored the effects of several chemopreventive agents, including green tea polyphenol and curcumin, on normal human keratinocyte function. our findings suggest that a bioactive polyphenol from green tea, (-)-epigallocatechin-3-gallate (egcg), acts to increase involucrin gene expression, suggesting that egc ...	2006	16404707
curcumin induces growth-arrest and apoptosis in association with the inhibition of constitutively active jak-stat pathway in t cell leukemia.	adult t cell leukemia is an aggressive and frequently fatal malignancy that expressess constitutively activated growth-signaling pathways in association with deregulated growth and resistance to apoptosis. curcumin (diferuloylmethane) is a naturally occurring yellow pigment, isolated from the rhizomes of the plant curcuma longa that has traditionally been used in the treatment of injury and inflammation. but the effect and mechanism of action of curcumin on t cell leukemia is not known. to inves ...	2006	16364242
comparative screening of plant essential oils: phenylpropanoid moiety as basic core for antiplatelet activity.	essential oils extracted from different plants (anthemis nobilis l., artemisia dracunculus l., cannabis sativa l., cupressus sempervirens l., cymbopogon citratus (dc.) stapf., curcuma longa l., foeniculum vulgare l., hypericum perforatum l., hyssopus officinalis l., mentha spicata l., monarda didyma l., ocimum basilicum l., ocotea quixos kosterm., origanum vulgare l., pinus nigra j.f. arnold, pinus silvestris l., piper crassinervium kunth., rosmarinus officinalis l., salvia officinalis l., salvi ...	2006	16274702
synergistic inhibitory effects of curcumin and 5-fluorouracil on the growth of the human colon cancer cell line ht-29.	the synergistic effect of combination treatment with cox-2 inhibitors and chemotherapy may be another promising therapy regimen in the future treatment of colorectal cancer. curcumin, a major yellow pigment in turmeric which is used widely all over the world, inhibits the growth of human colon cancer cell line ht-29 significantly and specifically inhibits the expression of cox-2 protein. however, the worldwide exposure of populations to curcumin raised the question of whether this agent would en ...	2006	16340194
the influence of curcumin and manganese complex of curcumin on cadmium-induced oxidative damage and trace elements status in tissues of mice.	curcumin (diferuoyl methane) from turmeric is a well-known biologically active compound. it has been shown to ameliorate oxidative stress and it is considered to be a potent cancer chemopreventive agent. in our previous study the antioxidative effects of curcumin in cadmium exposed animals were demonstrated. also manganese exerts protective effects in experimental cadmium intoxication. the present study examined the ability of the manganese complex of curcumin (mn-curcumin) and curcumin to prote ...	2006	16345010
curcumin and its analogues as potent inhibitors of low density lipoprotein oxidation: h-atom abstraction from the phenolic groups and possible involvement of the 4-hydroxy-3-methoxyphenyl groups.	curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, 1) is a yellow ingredient isolated from turmeric (curcumin longa). it has been shown to exhibit a variety of biological activities including antioxidative activity. in order to find more active antioxidants with 1 as the lead compound we synthesized curcumin analogues, i.e., 1,7-bis(3,4-dihydroxyphenyl)-1,6-heptadiene-3,5-dione (2), 1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (3), 1-(4-hydro ...	2006	16443168
inhibition of telomerase activity and induction of apoptosis by curcumin in k-562 cells.	telomerase, a reverse transcriptase that maintains telomere length, is highly activated in tumor cells and practically absent in somatic cells and hence considered a potential marker for tumorigenesis. a connection between telomerase activity and resistance to apoptosis has been established. telomerase, therefore, has been proposed to represent a novel and potentially selective target for cancer therapy. several synthetic compounds have been developed in recent years with a view to inhibit telom ...	2006	16445949
the effects of cannabinoids on p-glycoprotein transport and expression in multidrug resistant cells.	cannabis is the most widely used illicit drug in the world. cannabinoids are used therapeutically by some patients as they have analgesic, anti-emetic and appetite stimulant properties which palliate adverse symptoms. use of these agents in an oncology setting raises the question of whether they act to modulate the effectiveness of concurrently administered anti-cancer drugs. the transporter, p-glycoprotein (p-gp) confers multiple drug resistance (mdr) by effluxing a diverse array of anti-cancer ...	2006	16458258
suppressive effects of jcicm-6, the extract of an anti-arthritic herbal formula, on the experimental inflammatory and nociceptive models in rodents.	jcicm-6, the extract of an anti-arthritic herbal formula composed of medicinal herbs of sinomenium acutum, aconitum carmichaeli debx., curcuma longa l., paeonia lactiflora pall., and paeonia suffruticosa andr., was examined in the effectiveness and mechanism in reducing experimentally-induced inflammation and nociception using nine animal models. jcicm-6 was extracted from herbs and purified with amberlite xad-7hp adsorbent resin and analyzed with hplc-fingerprint for quality consistency. in acu ...	2006	16462027
ethnobotany of medicinal plants used by assamese people for various skin ailments and cosmetics.	the present paper deals with the medicinal plants used by the people of assam for curing different skin ailments and for cosmetics. a total of 85 plants belonging to 49 families have been documented for their therapeutic use against skin diseases and as herbal care. the herbal medicines were prepared from various plant parts of single plant, or multiple plants. the majority of the preparation was made using water as the medium. the mode of application was topical, but in many cases it was also a ...	2006	16473486
curcumin inhibits the proliferation and mineralization of cultured osteoblasts.	the effects of curcumin, which is an important constituent of rhizomes of the plant curcuma longa linn, on the metabolism of osteoblasts were examined in cultures of rat calvarial osteoblastic cells (rob cells). the proliferation of cells was markedly inhibited upon exposure of cells to curcumin at 5x10(-6) to 1x10(-5) m. curcumin at 1x10(-5) m did not induce apoptosis in rob cells but arrested cells at the g1 phase of the cell cycle. in addition, curcumin stimulated the expression of mrna for p ...	2006	16476424
study of the preparation of sustained-release microspheres containing zedoary turmeric oil by the emulsion-solvent-diffusion method and evaluation of the self-emulsification and bioavailability of the oil.	the purpose of this study was to design a sustained-release formulation of an oily drug. the sustained-release microspheres with self-emulsifying capability containing zedoary turmeric oil (zto) were prepared by the quasi-emulsion-solvent-diffusion method. the micromeritic properties, the efficiency of emulsification and the drug-release behavior of the resultant microspheres were investigated. the bioavailability of the microspheres was compared with conventional zto self-emulsifying formulatio ...	2006	16480856
targeting angiogenesis with integrative cancer therapies.	an integrative approach for managing a patient with cancer should target the multiple biochemical and physiological pathways that support tumor development while minimizing normal tissue toxicity. angiogenesis is a key process in the promotion of cancer. many natural health products that inhibit angiogenesis also manifest other anticancer activities. the authors will focus on natural health products (nhps) that have a high degree of antiangiogenic activity but also describe some of their many ot ...	2006	16484711
curcumin induces heme oxygenase-1 in hepatocytes and is protective in simulated cold preservation and warm reperfusion injury.	preconditioning treatments hold significant potential for improving outcomes in solid organ transplantation. protective phenotypes can be induced using certain drugs. curcumin is a biologically active component of turmeric and has been reported to induce stress proteins in certain cell lines, leading to cell protection. this study investigates in detail the effect of curcumin on the stress-response in human hepatocytes, in particular its effect on heme oxygenase 1 (ho-1) and its cytoprotective e ...	2006	16495813
comparison of anti-inflammatory activities of six curcuma rhizomes: a possible curcuminoid-independent pathway mediated by curcuma phaeocaulis extract.	we aimed to compare the anti-inflammatory activities of six species of curcuma drugs using adjuvant arthritis model mice. when orally administered 1 day before the injection of adjuvant, the methanol extract of curcuma phaeocaulis significantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. also when orally administered 1 day after the injection of adjuvant, the methanol extract of curcuma phaeocaulis significantly inhibited paw swelling. other curcuma ...	2006	16786056
antimicrobial effect of spices and herbs on vibrio parahaemolyticus.	the antimicrobial effects of spices and herbs from 18 plant species were examined on a foodborne pathogen, vibrio parahaemolyticus, with the use of combinations of temperatures and nutrient levels. basil, clove, garlic, horseradish, marjoram, oregano, rosemary, and thyme exhibited antibacterial activities at incubation of 30 degrees c, while with the exception of horseradish, the same spices and additional 7 species exhibited the activities at 5 degrees c. the lowest mic (minimum inhibitory conc ...	2006	16797760
overexpression of p65/rela potentiates curcumin-induced apoptosis in hct116 human colon cancer cells.	curcumin, the yellow pigment in the spice turmeric, has potent chemopreventive activities that involve diverse molecular pathways. it is widely believed that curcumin pro-apoptotic properties are mediated by downregulation of nf kappa b (nfkappab). the p65/rela subunit of nfkappab may influence cell death, in part by activation of nfkappab anti-apoptotic target genes including x-linked inhibitor of apoptosis (xiap), a20, bcl-xl and inhibition of sustained activation of c-jun n-terminal kinase (j ...	2006	16497702
evidence that curcuma longa possesses an active hypolipidemic effects in rabbits.		2006	16501692
inhibitory effect of cinnamoyl compounds against human malignant cell line.	in the present study, anti-proliferative effects of dietary polyphenolic compounds have been observed and demonstrated the strong anticancer efficacy of curcumin (cmn), an active constituent of dietary spice (turmeric) using human leukemia cancer cell line. cmn inhibited the proliferation of k562 leukemic cells by induction of apoptosis. the current study demonstrated synergy with combination of drug therapy, and suggested that combination of ferulic acid and cisplatin synergistically inhibited ...	2006	16538860
effect of curcuma longa and ocimum sanctum on myocardial apoptosis in experimentally induced myocardial ischemic-reperfusion injury.	in the present investigation, the effect of curcuma longa (cl) and ocimum sanctum (os) on myocardial apoptosis and cardiac function was studied in an ischemia and reperfusion (i-r) model of myocardial injury.	2006	16504000
ethnoveterinary medicines used for horses in trinidad and in british columbia, canada.	this paper investigates the commonalities in ethnoveterinary medicine used for horses between trinidad (west indies) and british columbia (canada). these research areas are part of a common market in pharmaceuticals and are both involved in the north american racing circuit. there has been very little research conducted on medicinal plants used for horses although their use is widespread. the data on ethnoveterinary medicines used for horses was obtained through key informant interviews with hor ...	2006	16893454
selective protection of curcumin against carbon tetrachloride-induced inactivation of hepatic cytochrome p450 isozymes in rats.	we investigated the effects of curcumin, a major antioxidant constituent of turmeric, on hepatic cytochrome p450 (cyp) activity in rats. wistar rats received curcumin-containing diets (0.05, 0.5 and 5 g/kg diet) with or without injection of carbon tetrachloride (ccl(4)). the hepatic cyp content and activities of six cyp isozymes remained unchanged by curcumin treatment, except for the group treated with the extremely high dose (5 g/kg). this suggested that daily dose of curcumin does not cause c ...	2006	16288784
curcumin modulates drug metabolizing enzymes in the female swiss webster mouse.	curcumin, the yellow pigment found in turmeric, exhibits potent chemopreventative properties in both in vivo and in vitro cancer models. we hypothesized that this effect may occur via curcumin-mediated changes in enzymes involved in both carcinogen bioactivation and estrogen metabolism. female swiss webster mice were treated with either curcumin (200 mg/kg or 400 mg/kg, p.o.) or vehicle control for 1 or 2 weeks. the results demonstrated that curcumin had no effect on the catalytic activities of ...	2006	16297412
prevention of kainic acid-induced changes in nitric oxide level and neuronal cell damage in the rat hippocampus by manganese complexes of curcumin and diacetylcurcumin.	curcumin is a natural antioxidant isolated from the medicinal plant curcuma longa linn. we previously reported that manganese complexes of curcumin (cp-mn) and diacetylcurcumin (diac-cp-mn) exhibited potent superoxide dismutase (sod)-like activity in an in vitro assay. nitric oxide (no) is a free radial playing a multifaceted role in the brain and its excessive production is known to induce neurotoxicity. here, we examined the in vivo effect of cp-mn and diac-cp-mn on no levels enhanced by kaini ...	2006	16266725
curcumin inhibits platelet-derived growth factor-stimulated vascular smooth muscle cell function and injury-induced neointima formation.	vascular smooth muscle cell (vsmc) migration, proliferation, and collagen synthesis are key events involved in the pathogenesis of cardiovascular disease. growth factors, such as platelet-derived growth factor (pdgf) and fibroblast growth factor, released during vascular injury plays a pivotal role in regulating these events. curcumin (diferuloyl methane), a major component of the spice turmeric (curcuma longa), has been shown recently to have beneficial effects in chronic conditions, such as in ...	2006	16239599
inhibition of lipid peroxidation and protein oxidation in rat liver mitochondria by curcumin and its analogues.	curcumin (1,7-bis(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione, 1) is a yellow ingredient isolated from turmeric (curcumin longa). it has been shown to exhibit a variety of biological activities including antioxidative activity. in order to find more active antioxidants with 1 as the lead compound we synthesized curcumin analogues, i.e., 1-(3,4-dihydroxyphenyl)-7-(4-hydroxy-3-methoxyphenyl)-1,6-heptadiene-3,5-dione (2), 1-(4-hydroxy-3-methoxyphenyl)-7-(4-hydroxyphenyl)-1,6-heptadiene-3,5- ...	2006	16236451
antiproliferation and apoptosis induced by curcumin in human ovarian cancer cells.	curcumin, an active ingredient from the rhizome of the plant, curcuma longa, has antioxidant, anti-inflammatory and anti-cancer activities. it has recently been demonstrated that the chemopreventive activities of curcumin might be due to its ability to inhibit cell growth and induce apoptosis. in the present study, we have investigated the effects of curcumin on growth and apoptosis in the human ovarian cancer cell line ho-8910 by mtt assay, fluorescence microscopy, flow cytometry and western bl ...	2006	16376585
curcumin inhibits human colon cancer cell growth by suppressing gene expression of epidermal growth factor receptor through reducing the activity of the transcription factor egr-1.	high expression of epidermal growth factor receptor (egfr) is found in a variety of solid tumors, including colorectal cancer. egfr has been identified as a rational target for anticancer therapy. curcumin, the yellow pigment of turmeric in curry, has received attention as a promising dietary supplement for cancer prevention and treatment. we recently reported that curcumin inhibited the growth of human colon cancer-derived moser cells by suppressing gene expression of cyclind1 and egfr. the aim ...	2006	16170359
curcuminoids purified from turmeric powder modulate the function of human multidrug resistance protein 1 (abcc1).	multidrug resistance is a major cause of chemotherapy failure in cancer patients. one of the resistance mechanisms is the overexpression of drug efflux pumps such as p-glycoprotein and multidrug resistance protein 1 (mrp1, (abcc1)). in this study, curcumin mixture and three major curcuminoids purified from turmeric (curcumin i, ii, and iii) were tested for their ability to modulate the function of mrp1 using hek293 cells stably transfected with mrp1-pcdna3.1 and pcdna3.1 vector alone. the ic(50) ...	2006	16021489